KR20200071198A - Nrf2 발현 조절 기반 T 세포 항암면역치료법 - Google Patents

Nrf2 발현 조절 기반 T 세포 항암면역치료법 Download PDF

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KR20200071198A
KR20200071198A KR1020180158428A KR20180158428A KR20200071198A KR 20200071198 A KR20200071198 A KR 20200071198A KR 1020180158428 A KR1020180158428 A KR 1020180158428A KR 20180158428 A KR20180158428 A KR 20180158428A KR 20200071198 A KR20200071198 A KR 20200071198A
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nrf2
cell
cancer
cells
expression
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홍창완
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네오이뮨텍, 인코퍼레이티드
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Priority to KR1020180158428A priority Critical patent/KR20200071198A/ko
Priority to AU2019398111A priority patent/AU2019398111A1/en
Priority to JP2021532865A priority patent/JP7813453B2/ja
Priority to CA3122096A priority patent/CA3122096A1/en
Priority to PCT/US2019/065227 priority patent/WO2020123377A1/en
Priority to EP19842433.5A priority patent/EP3893900B1/en
Priority to US17/312,361 priority patent/US20220016169A1/en
Priority to KR1020217021509A priority patent/KR20210102359A/ko
Priority to CN201980089769.6A priority patent/CN113395973A/zh
Publication of KR20200071198A publication Critical patent/KR20200071198A/ko
Priority to JP2025148485A priority patent/JP2025175073A/ja
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KR1020180158428A 2018-12-10 2018-12-10 Nrf2 발현 조절 기반 T 세포 항암면역치료법 Pending KR20200071198A (ko)

Priority Applications (10)

Application Number Priority Date Filing Date Title
KR1020180158428A KR20200071198A (ko) 2018-12-10 2018-12-10 Nrf2 발현 조절 기반 T 세포 항암면역치료법
EP19842433.5A EP3893900B1 (en) 2018-12-10 2019-12-09 Nrf-2 deficient cells and uses thereof
JP2021532865A JP7813453B2 (ja) 2018-12-10 2019-12-09 Nrf-2欠損細胞及びその使用
CA3122096A CA3122096A1 (en) 2018-12-10 2019-12-09 Nrf-2 deficient cells and uses thereof
PCT/US2019/065227 WO2020123377A1 (en) 2018-12-10 2019-12-09 Nrf-2 deficient cells and uses thereof
AU2019398111A AU2019398111A1 (en) 2018-12-10 2019-12-09 Nrf-2 deficient cells and uses thereof
US17/312,361 US20220016169A1 (en) 2018-12-10 2019-12-09 Nrf-2 deficient cells and uses thereof
KR1020217021509A KR20210102359A (ko) 2018-12-10 2019-12-09 Nrf-2 결핍 세포 및 이의 용도
CN201980089769.6A CN113395973A (zh) 2018-12-10 2019-12-09 Nrf-2缺陷型细胞及其用途
JP2025148485A JP2025175073A (ja) 2018-12-10 2025-09-08 Nrf-2欠損細胞及びその使用

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KR1020180158428A KR20200071198A (ko) 2018-12-10 2018-12-10 Nrf2 발현 조절 기반 T 세포 항암면역치료법

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KR1020217021509A Ceased KR20210102359A (ko) 2018-12-10 2019-12-09 Nrf-2 결핍 세포 및 이의 용도

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US (1) US20220016169A1 (https=)
EP (1) EP3893900B1 (https=)
JP (2) JP7813453B2 (https=)
KR (2) KR20200071198A (https=)
CN (1) CN113395973A (https=)
AU (1) AU2019398111A1 (https=)
CA (1) CA3122096A1 (https=)
WO (1) WO2020123377A1 (https=)

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WO2021127392A1 (en) * 2019-12-19 2021-06-24 H. Lee Moffitt Cancer Center And Research Institute, Inc. Systems and methods for predicting individual patient response to radiotherapy using a dynamic carrying capacity model

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
US5543390A (en) 1990-11-01 1996-08-06 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University Covalent microparticle-drug conjugates for biological targeting
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US6274552B1 (en) 1993-03-18 2001-08-14 Cytimmune Sciences, Inc. Composition and method for delivery of biologically-active factors
US5985307A (en) 1993-04-14 1999-11-16 Emory University Device and method for non-occlusive localized drug delivery
US5523092A (en) 1993-04-14 1996-06-04 Emory University Device for local drug delivery and methods for using the same
US6004534A (en) 1993-07-23 1999-12-21 Massachusetts Institute Of Technology Targeted polymerized liposomes for improved drug delivery
US5759542A (en) 1994-08-05 1998-06-02 New England Deaconess Hospital Corporation Compositions and methods for the delivery of drugs by platelets for the treatment of cardiovascular and other diseases
US5660854A (en) 1994-11-28 1997-08-26 Haynes; Duncan H Drug releasing surgical implant or dressing material
US6316652B1 (en) 1995-06-06 2001-11-13 Kosta Steliou Drug mitochondrial targeting agents
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US6039975A (en) 1995-10-17 2000-03-21 Hoffman-La Roche Inc. Colon targeted delivery system
TW345603B (en) 1996-05-29 1998-11-21 Gmundner Fertigteile Gmbh A noise control device for tracks
JP2000508339A (ja) 1996-10-01 2000-07-04 シーマ・ラブス・インコーポレイテッド 味隠蔽マイクロカプセル組成物及び製造方法
PT904392E (pt) 1996-10-17 2001-06-29 Oxford Biomedica Ltd Vectores retrovirais
GB9621680D0 (en) 1996-10-17 1996-12-11 Oxford Biomedica Ltd Lentiviral vectors
GB9622500D0 (en) 1996-10-29 1997-01-08 Oxford Biomedica Ltd Therapeutic gene
US6131570A (en) 1998-06-30 2000-10-17 Aradigm Corporation Temperature controlling device for aerosol drug delivery
US6120751A (en) 1997-03-21 2000-09-19 Imarx Pharmaceutical Corp. Charged lipids and uses for the same
US6060082A (en) 1997-04-18 2000-05-09 Massachusetts Institute Of Technology Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
US6271359B1 (en) 1999-04-14 2001-08-07 Musc Foundation For Research Development Tissue-specific and pathogen-specific toxic agents and ribozymes
US8202846B2 (en) 2000-03-16 2012-06-19 Cold Spring Harbor Laboratory Methods and compositions for RNA interference
EP1272630A2 (en) 2000-03-16 2003-01-08 Genetica, Inc. Methods and compositions for rna interference
WO2003087341A2 (en) 2002-01-23 2003-10-23 The University Of Utah Research Foundation Targeted chromosomal mutagenesis using zinc finger nucleases
AU2003215869B2 (en) 2002-03-15 2008-04-24 Cellectis Hybrid and single chain meganucleases and use thereof
WO2003080809A2 (en) 2002-03-21 2003-10-02 Sangamo Biosciences, Inc. Methods and compositions for using zinc finger endonucleases to enhance homologous recombination
EP2806025B1 (en) 2002-09-05 2019-04-03 California Institute of Technology Use of zinc finger nucleases to stimulate gene targeting
AU2003290518A1 (en) 2002-09-06 2004-04-23 Fred Hutchinson Cancer Research Center Methods and compositions concerning designed highly-specific nucleic acid binding proteins
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
EP1591521A1 (en) 2004-04-30 2005-11-02 Cellectis I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
AU2005287278B2 (en) 2004-09-16 2011-08-04 Sangamo Biosciences, Inc. Compositions and methods for protein production
WO2006097784A1 (en) 2005-03-15 2006-09-21 Cellectis I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
EP1863909B2 (en) 2005-03-15 2014-09-10 Cellectis I-crei meganuclease variants with modified specificity, method of preparation and uses thereof
US7812002B2 (en) * 2007-03-21 2010-10-12 Quark Pharmaceuticals, Inc. Oligoribonucleotide inhibitors of NRF2 and methods of use thereof for treatment of cancer
US20110239315A1 (en) 2009-01-12 2011-09-29 Ulla Bonas Modular dna-binding domains and methods of use
EP2206723A1 (en) 2009-01-12 2010-07-14 Bonas, Ulla Modular DNA-binding domains
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
WO2011072246A2 (en) 2009-12-10 2011-06-16 Regents Of The University Of Minnesota Tal effector-mediated dna modification
US9637739B2 (en) 2012-03-20 2017-05-02 Vilnius University RNA-directed DNA cleavage by the Cas9-crRNA complex
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
AU2013335451C1 (en) 2012-10-23 2024-07-04 Toolgen Incorporated Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
PL3360964T3 (pl) 2012-12-06 2020-03-31 Sigma-Aldrich Co. Llc Modyfikacja i regulacja genomu oparta na crispr
EP3031921B1 (en) 2012-12-12 2025-03-12 The Broad Institute, Inc. Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
DK2931891T3 (da) 2012-12-17 2019-08-19 Harvard College Rna-styret modificering af menneskelige genomer
EP2922393B2 (en) 2013-02-27 2022-12-28 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Gene editing in the oocyte by cas9 nucleases
EP3155116A4 (en) 2014-06-10 2017-12-27 Massachusetts Institute Of Technology Method for gene editing
CN104877967A (zh) * 2015-05-26 2015-09-02 中山大学附属第三医院 一种过表达Nrf2基因的细胞株MSCs及其制备方法及应用
MX2020008581A (es) 2018-02-21 2020-09-21 Bristol Myers Squibb Co Oligonucleotidos antisentido de la proteina cinasa del tipo ii delta dependiente del calcio/calmodulina (camk2d) y sus usos.

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WO2020123377A1 (en) 2020-06-18
JP7813453B2 (ja) 2026-02-13
CN113395973A (zh) 2021-09-14
EP3893900C0 (en) 2025-11-05
EP3893900A1 (en) 2021-10-20
JP2025175073A (ja) 2025-11-28
AU2019398111A1 (en) 2021-07-08
JP2022514219A (ja) 2022-02-10
CA3122096A1 (en) 2020-06-18
EP3893900B1 (en) 2025-11-05
KR20210102359A (ko) 2021-08-19
US20220016169A1 (en) 2022-01-20

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