KR20200070416A - Tor 키나제 억제자를 사용하는 암의 치료 - Google Patents

Tor 키나제 억제자를 사용하는 암의 치료 Download PDF

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Publication number
KR20200070416A
KR20200070416A KR1020207016306A KR20207016306A KR20200070416A KR 20200070416 A KR20200070416 A KR 20200070416A KR 1020207016306 A KR1020207016306 A KR 1020207016306A KR 20207016306 A KR20207016306 A KR 20207016306A KR 20200070416 A KR20200070416 A KR 20200070416A
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KR
South Korea
Prior art keywords
substituted
unsubstituted
pyrazin
tor kinase
methyl
Prior art date
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Ceased
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KR1020207016306A
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English (en)
Korean (ko)
Inventor
슈이찬 주
크리스튼 메이 헤게
헤더 레이몬
릴리 로레인 웡
Original Assignee
시그날 파마소티칼 엘엘씨
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Publication date
Application filed by 시그날 파마소티칼 엘엘씨 filed Critical 시그날 파마소티칼 엘엘씨
Priority to KR1020217017407A priority Critical patent/KR20210071101A/ko
Publication of KR20200070416A publication Critical patent/KR20200070416A/ko
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207016306A 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료 Ceased KR20200070416A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217017407A KR20210071101A (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261611361P 2012-03-15 2012-03-15
US61/611,361 2012-03-15
US201261715323P 2012-10-18 2012-10-18
US61/715,323 2012-10-18
PCT/US2013/031206 WO2013138557A1 (en) 2012-03-15 2013-03-14 Treatment of cancer with tor kinase inhibitors

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147028707A Division KR102122617B1 (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217017407A Division KR20210071101A (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료

Publications (1)

Publication Number Publication Date
KR20200070416A true KR20200070416A (ko) 2020-06-17

Family

ID=48014336

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020207016306A Ceased KR20200070416A (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료
KR1020147028707A Active KR102122617B1 (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료
KR1020217017407A Ceased KR20210071101A (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020147028707A Active KR102122617B1 (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료
KR1020217017407A Ceased KR20210071101A (ko) 2012-03-15 2013-03-14 Tor 키나제 억제자를 사용하는 암의 치료

Country Status (21)

Country Link
US (1) US20130245026A1 (enExample)
EP (1) EP2825170B1 (enExample)
JP (3) JP2015510891A (enExample)
KR (3) KR20200070416A (enExample)
CN (2) CN108992446A (enExample)
AU (1) AU2013203153B2 (enExample)
BR (1) BR112014022703A2 (enExample)
CA (1) CA2866872A1 (enExample)
EA (1) EA028414B1 (enExample)
ES (1) ES2677874T3 (enExample)
IL (1) IL234602B (enExample)
MX (1) MX360878B (enExample)
MY (1) MY174022A (enExample)
NI (1) NI201400111A (enExample)
NZ (1) NZ628416A (enExample)
PH (1) PH12014502029B1 (enExample)
SG (1) SG11201405707XA (enExample)
TW (1) TWI583385B (enExample)
UA (1) UA114315C2 (enExample)
WO (1) WO2013138557A1 (enExample)
ZA (1) ZA201406706B (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2825170B1 (en) * 2012-03-15 2018-05-09 Signal Pharmaceuticals, LLC Treatment of cancer with tor kinase inhibitors
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
US9346812B2 (en) 2013-01-16 2016-05-24 Signal Pharmaceuticals, Llc Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith
CA2909579A1 (en) 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer
US20140314673A1 (en) * 2013-04-17 2014-10-23 Signal Pharmaceuticals, Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629332A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629411A (en) 2013-04-17 2017-06-30 Signal Pharm Llc Treatment of cancer with dihydropyrazino-pyrazines
NZ629469A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Methods for treating cancer using dihydropyrazino-pyrazine compound combination therapy
EP2986322A1 (en) 2013-04-17 2016-02-24 Signal Pharmaceuticals, LLC Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
MX374749B (es) 2013-04-17 2025-03-06 Signal Pharm Llc Terapia de combinacion que comprende un inhibidor de tor cinasa y un analogo de citidina para tratar cancer.
NZ629230A (en) 2013-04-17 2017-05-26 Signal Pharm Llc Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one
HK1223286A1 (zh) 2013-05-29 2017-07-28 西格诺药品有限公司 7-(6-(2-羟基丙-2-基)吡啶-3-基)-1-((反式)-4-甲氧基环己基)-3，4-二氢吡嗪并[2，3-b]吡嗪-2(1h)-酮的药物组合物、其固体形式及它们的使用方法
EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
NZ714742A (en) 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
WO2015160868A1 (en) 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Methods for treating cancer using tor kinase inhibitor combination therapy
NZ629796A (en) 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
WO2016010886A1 (en) 2014-07-14 2016-01-21 Signal Pharmaceuticals, Llc Methods of treating a cancer using substituted pyrrolopyrimidine compounds, compositions thereof
MY198676A (en) 2017-06-22 2023-09-15 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200902384B (en) 2006-10-19 2010-07-28 Signal Pharm Llc Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors
CN105693730A (zh) * 2006-10-19 2016-06-22 西格诺药品有限公司 杂芳基化合物、其组合物以及它们作为蛋白激酶抑制剂的用途
EP2320894B1 (en) * 2008-08-20 2016-12-28 The United States of America, as represented by the Secretary, Department of Health and Human Services Chemoprevention of head and neck squamous cell carcinomas
US8110578B2 (en) * 2008-10-27 2012-02-07 Signal Pharmaceuticals, Llc Pyrazino[2,3-b]pyrazine mTOR kinase inhibitors for oncology indications and diseases associated with the mTOR/PI3K/Akt pathway
CA2778615C (en) 2009-10-26 2019-04-23 Signal Pharmaceuticals, Llc Methods of synthesis and purification of heteroaryl compounds
US20120028972A1 (en) * 2010-07-30 2012-02-02 Lilly Wong Biomarker assays for detecting or measuring inhibition of tor kinase activity
EP2825170B1 (en) * 2012-03-15 2018-05-09 Signal Pharmaceuticals, LLC Treatment of cancer with tor kinase inhibitors

Also Published As

Publication number Publication date
PH12014502029A1 (en) 2014-11-24
EA028414B1 (ru) 2017-11-30
KR20210071101A (ko) 2021-06-15
EP2825170A1 (en) 2015-01-21
CA2866872A1 (en) 2013-09-19
UA114315C2 (uk) 2017-05-25
KR20140138927A (ko) 2014-12-04
JP2015510891A (ja) 2015-04-13
JP2021102637A (ja) 2021-07-15
EA201491699A1 (ru) 2015-02-27
ZA201406706B (en) 2016-05-25
JP2019108368A (ja) 2019-07-04
KR102122617B1 (ko) 2020-06-12
BR112014022703A2 (pt) 2021-05-04
NZ628416A (en) 2016-04-29
IL234602B (en) 2020-05-31
IL234602A0 (en) 2014-11-30
MX2014011077A (es) 2014-10-14
EP2825170B1 (en) 2018-05-09
ES2677874T3 (es) 2018-08-07
PH12014502029B1 (en) 2014-11-24
TW201343168A (zh) 2013-11-01
WO2013138557A1 (en) 2013-09-19
MX360878B (es) 2018-11-21
CN108992446A (zh) 2018-12-14
NI201400111A (es) 2015-01-15
CN104519885A (zh) 2015-04-15
US20130245026A1 (en) 2013-09-19
AU2013203153B2 (en) 2015-09-03
AU2013203153A1 (en) 2013-10-03
SG11201405707XA (en) 2014-10-30
TWI583385B (zh) 2017-05-21
MY174022A (en) 2020-03-04
HK1201750A1 (en) 2015-09-11

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