KR20200069572A - Distance corrected wireless gamma probe and method of measuring radiation intensity thereof - Google Patents

Abstract

The present invention relates to a distance correction gamma probe which can obtain accurate information of a subject such as a tumor. The distance correction gamma probe comprises: a wireless gamma probe (100) irradiating radiation and a laser to a subject (400) and obtaining information on the radiation and laser reflected from the subject (400) to wirelessly transmit the information; and a control device (200) obtaining the distance to the subject and the intensity of the radiation by the information on the radiation and laser wirelessly transmitted from the wireless gamma probe (100) and, after obtaining radiation intensity correction information therefrom, correcting the intensity of the radiation.

Description

Distance corrected wireless gamma probe and method of measuring radiation intensity thereof

The present invention relates to a distance-adjusted gamma probe, and more specifically, to correct the intensity of radiation emitted from a subject, such as a tumor, according to the distance between the object and a gamma probe, such as a tumor obtained by laser and radiation reflected from the subject. The present invention relates to a distance-compensated wireless gamma probe and a method for radio-radiation measurement of a distance-compensated gamma probe.

Generally, nuclear medicine refers to radiation emitted from a radiopharmaceutical or radiotracer injected into the body, and then embodied as an image to diagnose a patient's physiological or pathological condition, or It is a medical field to treat.

Radioimmunoscintigraphy (RIS), a technique for imaging tumors using radiopharmaceuticals, and radioimmunoguided surgery, a technique for removing tumors, by establishing a foundational knowledge through continuous research in the field of nuclear medicine imaging and treatment , RIGS) are constantly being researched and developed.

This technique is a technique for imaging a tumor by labeling a radioisotope on an antibody against a tumor, and aims to detect gamma-rays emitted from radiopharmaceuticals specifically integrated only in the tumor. .

This is an important technique that can overcome the limitations due to the low therapeutic performance of incision and anticancer drug treatment used as standard surgery in the treatment of thyroid cancer, stomach cancer or colorectal cancer by using appropriate tumor markers.

As described above, for the diagnosis and treatment of tumors using radiopharmaceuticals, imaging equipment for nuclear medicine is essential to obtain information on the distribution and location of radiopharmaceuticals.

In general, during RIGS surgery, a gamma probe is used to detect gamma rays generated in radiopharmaceuticals accumulated in a tumor. It is free to move in the operating room compared to the existing nuclear medicine diagnostic equipment such as gamma camera, positron emission tomography (PET), single photon emission computed tomography (SPECT), etc. It is possible. In addition, it has the advantage of being able to evaluate the presence and/or location of residual cancer in real time.

However, commercialized gamma probes for imaging have the disadvantage of having a low spatial resolution and requiring a long data acquisition time for image realization.

In addition, unlike counting gamma probes, electronic equipment including a position encoding circuit for realizing an image in addition to an optical measuring device is additionally required. Therefore, there is also a disadvantage that the entire detection system is bulky.

In addition, some radiopharmaceuticals emit positrons, and then release beta and gamma rays in the process of stabilizing the unstable atomic nuclei in the excited state to the ground state.

To this end, a radiation detector using a scintillation sensor is disclosed. In general, a photomultiplier tube (PMT) is mainly used as an optical measuring device for a scintillation radiation detector. In the case of optical multipliers (especially multi-channel optical multipliers), it is difficult to adjust the amplification factor and offset voltage in each channel equally.

Incidentally, since the light intensity of the scintillation signal is very low, for the conversion of electrical signals using optical multiplier, amplification and offset, for the purpose of determining the location of multiple amplifiers and events and implementing images The disadvantage is that additional circuits such as a position detection circuit are required.

On the other hand, since the intensity of radiation is inversely proportional to the square of the distance, the measurement value varies from several times to several tens of times even at a distance of several centimeters, so correcting the intensity of radiation according to the distance is indispensable for accurate tumor location and treatment. to be.

However, the conventional technique as described above has a disadvantage that information on a subject, such as a tumor, is not accurate because the distance to a subject, such as a tumor, is not taken into account.

The present invention is to solve the problems of the prior art as described above, a distance-compensated wireless gamma probe and a distance-compensated wireless gamma probe capable of obtaining accurate information on a subject, such as a tumor, and a method for wirelessly measuring radiation of a distance-compensated gamma probe The purpose is to provide.

The object as described above is a gamma probe for irradiating a subject with radiation and a laser, and obtaining and transmitting information on radiation and laser reflected from the subject wirelessly; And a control device for obtaining a distance to an object and an intensity of radiation by using radiation and laser information transmitted wirelessly from the gamma probe, and obtaining radiation intensity correction information therefrom, and correcting the intensity of the radiation. The probe is a scintillation sensor that radiates light emitted from an object and reacts to it, a scintillation sensor that multiplies light emitted from the scintillation sensor by hundreds of thousands to millions of times, and electricity that is multiplied by the light multiplication device. A signal pre-processing unit that converts the signal into a digital signal and converts it back into a digital signal; A laser diode that irradiates the subject with a laser; It comprises a receiving unit for receiving a laser reflected from the subject and a Bluetooth module for wirelessly transmitting the radiation and the laser information, the control device, the Bluetooth module for receiving the radiation and the laser information wirelessly transmitted from the gamma probe , A distance calculating unit for calculating the distance between the gamma probe and the subject from the laser received through the Bluetooth module, a compensation information generating unit for generating compensation information corresponding to the distance between the gamma probe and the subject, and the Bluetooth module A distance comprising a radiation intensity calculator for calculating the intensity of radiation emitted from a subject from radiation information received through and a radiation intensity compensator for correcting the intensity of radiation in the radiation intensity calculator to compensation information of the compensation information generator It is achieved by a radiometric radiometric measurement method of a calibrated wireless gamma probe and a distance-compensated gamma probe.

According to one aspect of the present invention, the control device has a Bluetooth function, obtains a distance from the laser information to a subject, obtains radiation intensity correction information, obtains radiation intensity from the radiation information, and uses the radiation intensity correction information. It is characterized in that the mobile phone is equipped with an algorithm for correcting the radiation intensity corresponding to the distance from the subject.

According to another aspect of the present invention, the control device includes a Bluetooth function associated with an Internet network, obtains a distance from the laser information to a subject, obtains radiation intensity correction information, obtains radiation intensity from the radiation information, and obtains the radiation intensity It is characterized in that the server or terminal is equipped with an algorithm for correcting the radiation intensity to correspond to the distance to the subject by the correction information.

According to the present invention, the intensity of radiation emitted from a subject, such as a tumor, is corrected according to a distance between a gamma probe and a subject, such as a tumor, obtained by laser and radiation reflected from the subject, thereby accurately It has the effect of securing information.

1 is a block diagram of a distance-compensated wireless gamma probe according to an embodiment of the present invention.
FIG. 2 is a flow chart showing a process of measuring the intensity of radiation by the radio intensity measuring apparatus of FIG. 1.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings.

1 is a block diagram of a distance-compensated wireless gamma probe according to an embodiment of the present invention.

Referring to Figure 1, the distance-compensated wireless gamma probe according to an embodiment of the present invention, in the gamma probe for measuring the intensity of radiation emitted from a subject 400 such as a tumor, in the radiation emitted from the subject 400 Responsive to radiating light, irradiating the laser to the subject 400, and receiving the laser reflected from the subject 400 and transmitting the radio wirelessly, corresponding to the radiation received from the gamma probe 100 and the gamma probe 100 It is possible to wirelessly communicate with the gamma probe 100 that calculates the intensity of radiation, obtains compensation information by obtaining a distance between the gamma probe 100 and a subject 400 such as a tumor, and compensates the intensity of the radiation with the compensation information. The control device 200 is configured to include a display 300 such as a mobile phone or a server and a terminal on the Internet and a conventional LCD.

The control device 200 includes a Bluetooth function, obtains the distance from the laser information to the subject, obtains radiation intensity correction information, obtains the radiation intensity from the radiation information, and corresponds to the distance from the subject by the radiation intensity correction information. A mobile phone equipped with an algorithm to calibrate can be used.

In addition, the control device 200 is equipped with a Bluetooth function associated with the Internet network, obtains the distance from the laser information to the subject to obtain the radiation intensity correction information, obtains the radiation intensity from the radiation information, and determines the radiation intensity by the radiation intensity correction information. A server or a terminal equipped with an algorithm that corrects to correspond to the distance from may be used.

Here, the gamma probe 100, the radiation emitted from the subject 400 is incident and reacts with the scintillation sensor 110 for emitting light, the light emitted from the scintillation sensor 110 multiplied by hundreds of thousands to millions of times Device 120, a signal pre-processing unit 130 that converts the light multiplied by the light multiplication device 120 into an electrical signal and converts it back into a digital signal, a laser diode 140 that irradiates a laser to the subject 400 ), including a receiving unit 150 for receiving a laser reflected from the subject 400, a Bluetooth module 170 for wirelessly transmitting radiation and the laser information, and a collimator 161, 162, 163, 164 do. Each of the above components may be configured in the case 101. Of course, some of the components may be configured such that all or part of them are exposed to the outside of the case 101.

The flash sensor 110 is a device that emits light by radiation from a patient's tumor, and may include a reflector to prevent light leakage.

The scintillation sensor 110 generates light at the same time as the radiation emitted from the subject 400 is incident and transmits the light to the optical multiplication element 120. The amount of light emitted from the flash sensor 110 is proportional to the intensity of radiation emitted from the subject 400 and incident on the flash sensor 110. That is, it is proportional to the size of cancer cells.

As the material of the scintillation sensor 110, an inorganic scintillator crystal such as LYSO, BGO, CsI(Tl), or an organic scintillator such as a semiconductor crystal such as GAGG, CZT(CdZnTe) or a plastic scintillator may be used.

The optical multiplication element 120 multiplies the light emitted from the scintillation sensor 110 from hundreds of thousands to millions of times, converts it into an electrical signal, and provides it to the control module 200 through the signal pre-processing unit 130. The optical multiplier 120 may be implemented as a silicon photomultiplier (SiPM), an avalance photo diode (APD), or a photomultiplier tube (PMT).

The aimers 161, 162, 163, and 164 are mechanical focusing devices that block high energy gamma rays, such as gamma rays, from entering in an undesired direction, and tungsten is mainly used.

The receiving unit 150 paired with the laser diode 140 may be configured as one of a Silicon Photomultiplier (SiPM) and an Avalance Photo Diode (APD).

The Bluetooth module 170 is capable of wireless communication with a Bluetooth module of another product such as a known dongle, and can wirelessly transmit radiation and the laser information.

In addition, the control device 200 is a Bluetooth module 205 for receiving radiation and laser information wirelessly transmitted from the gamma probe 100, the gamma probe 100 and the subject 400 from the laser received through the Bluetooth module 205 ), the distance calculation unit 210 for calculating the distance, the gamma probe 100 and the compensation information generation unit 220 for generating compensation information corresponding to the distance between the subject 400, received through the Bluetooth module 205 Correcting the intensity of radiation of the radiation intensity calculator 230 and the radiation intensity calculator 230 to calculate the intensity of radiation emitted from the subject 400 from the radiation information as compensation information of the compensation information generator 220 It includes a radiation intensity correction unit 240.

Therefore, the control device 200 transmits a laser transmitted from the laser diode 140 to the subject 400 and then transmits the laser reflected and returned to the subject 400 through the receiver 150, and the transmission time and the laser. The distance between the gamma probe 100 and the subject 400 may be calculated by measuring Equation 1 below by measuring the difference time between the reception times of receiving the reflected light.

[Equation 1]

D = c * ΔT/2

D: Distance to the subject

c: speed of light

ΔT: Difference time between transmission time and reception time

The control device 200 generates compensation information of radiation intensity emitted from the subject 400 using the distance from the gamma probe 100 to the subject 400 received.

At this time, the control device 200 may generate radiation intensity compensation information using the radiation intensity of the gamma probe 100 inversely proportional to the square of the distance to the subject 400.

Information such as radiation intensity is output through the display 300.

FIG. 2 is a flow chart showing a process of measuring the intensity of radiation by the radio intensity measuring apparatus of FIG. 1.

According to FIG. 2, in the process of measuring the intensity of radiation emitted from the subject 400 by the gamma probe 100, the gamma probe 100 measures the intensity of radiation emitted from the object 400, gamma Through the probe 100, the radiation reflected and emitted from the subject 400 is received, and light is generated in response to the radiation (S11). In addition, a laser is irradiated to the subject 400, and the laser reflected from the subject 400 is received and wirelessly transmitted to the control apparatus 100 together with radiation (S12).

Subsequently, the control device 200 calculates the intensity of radiation based on the radiation information received from the gamma probe 100 (S13), and analyzes the laser information received from the gamma probe 100 to analyze the gamma probe 100 and the subject. The distance to the 400 is calculated and compensation information corresponding to the distance is generated (S14).

In addition, the control device 200 corrects the intensity of the radiation calculated above with the compensation information generated above.

Since the description of the present invention described above is only an example for structural or functional description, the scope of the present invention should not be interpreted as being limited by the examples described in the text. That is, the present invention is not limited by the above-described embodiments and the accompanying drawings, but is limited by the claims, which will be described later, and the configuration of the present invention is variously changed without departing from the technical spirit of the present invention. And since it can be modified, embodiments of the present invention can be variously modified and have various forms. Accordingly, it should be understood that the scope of the present invention includes equivalents capable of realizing technical ideas.

101: case 100: gamma probe
110: flash sensor 120: light multiplication element
130: signal pre-processing unit 140: laser diode
150: receiver 161, 162, 163, 164: aimer
170, 205: Bluetooth module 200: control device
210: distance calculation unit 220: correction information generation unit
230: radiation intensity calculation unit 240: radiation intensity correction unit
300: display 400: subject

Claims (4)

A gamma probe 100 that irradiates a subject 400 with radiation and a laser and acquires information about the radiation and laser reflected from the subject 400 and transmits the information wirelessly; And
Including the control device 200 for obtaining the distance to the subject and the intensity of the radiation from the radiation and laser information transmitted wirelessly from the gamma probe 100, and obtaining the radiation intensity correction information therefrom to correct the intensity of the radiation Composed,
The gamma probe 100,
A scintillation sensor 110 that emits light in response to and receives radiation emitted from the subject 400,
Light multiplication element 120 for multiplying the light emitted from the flash sensor 110 to hundreds of thousands to millions of times,
A signal pre-processing unit 130 converting the light multiplied by the optical multiplication element 120 into an electrical signal and converting it back into a digital signal;
Laser diode 140 for irradiating the laser to the subject 400,
Receiving unit 150 for receiving the laser reflected from the subject 400 and
It comprises a Bluetooth module 170 for wirelessly transmitting the radiation and the laser information,
The control device 200,
Bluetooth module 205 for receiving radiation and the laser information transmitted wirelessly from the gamma probe 100,
Distance calculation unit 210 for calculating the distance between the gamma probe 100 and the subject 400 from the laser received through the Bluetooth module 205,
Compensation information generation unit 220 for generating compensation information corresponding to the distance between the gamma probe 100 and the subject 400,
A radiation intensity calculator 230 for calculating the intensity of radiation emitted from the subject 400 from the radiation information received through the Bluetooth module 205 and
Radiation intensity correction unit 240 for correcting the intensity of the radiation of the radiation intensity calculation unit 230 to the compensation information of the compensation information generation unit 220
Distance-compensated wireless gamma probe comprising a.
According to claim 1,
The control device 200,
An algorithm having a Bluetooth function and obtaining a radiation intensity correction information by obtaining a distance from the laser information to a subject, and obtaining a radiation intensity from the radiation information and correcting the radiation intensity to correspond to a distance from the subject by the radiation intensity correction information A distance-compensated wireless gamma probe, characterized in that it is equipped with a mobile phone.
According to claim 1,
The control device 200,
Equipped with a Bluetooth function linked to the Internet network, the distance from the laser information to the subject is obtained to obtain radiation intensity correction information, and the radiation intensity is obtained from the radiation information to obtain the radiation intensity from the radiation intensity correction information to a distance from the subject. Distance-corrected wireless gamma probe, characterized in that the server or terminal equipped with an algorithm to compensate correspondingly.
A gamma probe 100 that irradiates a subject 400 with radiation and a laser and acquires information about the radiation and laser reflected from the subject 400 and transmits the information wirelessly; And
Including the control device 200 for obtaining the distance to the subject and the intensity of the radiation from the radiation and laser information transmitted wirelessly from the gamma probe 100, and obtaining the radiation intensity correction information therefrom to correct the intensity of the radiation Composed,
The gamma probe 100,
A scintillation sensor 110 that emits light in response to and receives radiation emitted from the subject 400,
Light multiplication element 120 for multiplying the light emitted from the flash sensor 110 to hundreds of thousands to millions of times,
A signal pre-processing unit 130 converting the light multiplied by the optical multiplication element 120 into an electrical signal and converting it back into a digital signal;
Laser diode 140 for irradiating the laser to the subject 400,
Receiving unit 150 for receiving the laser reflected from the subject 400 and
It comprises a Bluetooth module 170 for wirelessly transmitting the radiation and the laser information,
The control device 200,
Bluetooth module 205 for receiving radiation and the laser information transmitted wirelessly from the gamma probe 100,
Distance calculation unit 210 for calculating the distance between the gamma probe 100 and the subject 400 from the laser received through the Bluetooth module 205,
Compensation information generation unit 220 for generating compensation information corresponding to the distance between the gamma probe 100 and the subject 400,
A radiation intensity calculator 230 for calculating the intensity of radiation emitted from the subject 400 from the radiation information received through the Bluetooth module 205 and
Radiation intensity correction unit 240 for correcting the intensity of radiation of the radiation intensity calculation unit 230 to compensation information of the compensation information generation unit 220
Radiation measuring method of a distance-compensated wireless gamma probe, characterized in that consisting of.

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