KR20200067145A - Axl-특이적 항체 및 그의 용도 - Google Patents

Axl-특이적 항체 및 그의 용도 Download PDF

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KR20200067145A
KR20200067145A KR1020207010151A KR20207010151A KR20200067145A KR 20200067145 A KR20200067145 A KR 20200067145A KR 1020207010151 A KR1020207010151 A KR 1020207010151A KR 20207010151 A KR20207010151 A KR 20207010151A KR 20200067145 A KR20200067145 A KR 20200067145A
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ser
seq
thr
antibody
gly
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케빈 헨리
마리아 루즈 자라밀로
콜린 로저 메켄지
안 마르실
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내셔날 리서치 카운실 오브 캐나다
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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KR1020207010151A 2017-09-13 2018-09-10 Axl-특이적 항체 및 그의 용도 Ceased KR20200067145A (ko)

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Application Number Priority Date Filing Date Title
US201762557870P 2017-09-13 2017-09-13
US62/557,870 2017-09-13
PCT/CA2018/051108 WO2019051586A1 (en) 2017-09-13 2018-09-10 AXL SPECIFIC ANTIBODIES AND USES THEREOF

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US (2) US11739154B2 (enExample)
EP (1) EP3681912A4 (enExample)
JP (1) JP7366886B2 (enExample)
KR (1) KR20200067145A (enExample)
CN (1) CN111263770A (enExample)
AU (1) AU2018333290A1 (enExample)
BR (1) BR112020005011A2 (enExample)
CA (1) CA3075531A1 (enExample)
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Families Citing this family (15)

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Publication number Priority date Publication date Assignee Title
EP3551745A4 (en) * 2016-12-12 2020-07-15 Xcella Biosciences, Inc. SCREENING METHODS AND SYSTEMS USING MICROCAPILLARY NETWORKS
CN110382439B (zh) 2016-12-30 2026-07-21 埃克切拉生物科学公司 多级样品回收系统
DK3890876T3 (da) 2018-12-06 2024-07-22 Xcella Biosciences Inc Lateral påfyldning af mikrokapillære arrays
CA3156776A1 (en) 2019-11-08 2021-05-14 xCella Biosciences, Inc. Apparatus and methods for laser-based single cell recovery from microcapillary arrays
CN113045664B (zh) * 2019-11-28 2023-05-12 尚健单抗（北京）生物技术有限公司 一种分离的结合抗原axl的蛋白及其用途
WO2021154156A1 (en) * 2020-01-31 2021-08-05 Agency For Science, Technology And Research Anti-axl antibody and uses thereof
WO2021253335A1 (zh) * 2020-06-18 2021-12-23 深圳迈瑞生物医疗电子股份有限公司 抗可溶性cd14亚型抗体、试剂盒及其应用
MX2023005571A (es) * 2020-11-12 2023-07-31 Bioatla Inc Metodos de tratamiento de canceres que expresan axl con anticuerpos anti-axl, fragmentos de anticuerpos y sus inmunoconjugados.
CN115125272B (zh) * 2021-03-29 2024-04-19 复旦大学 一种car-t治疗载体及其构建方法和应用
AU2021451307A1 (en) * 2021-06-16 2024-02-01 Shanghai Sinobay Biotechnology Co., Ltd. Antibody targeting axl protein and antigen binding fragment thereof, preparation method therefor and use thereof
US20240025996A1 (en) * 2022-07-11 2024-01-25 Fred Hutchinson Cancer Center Igm-multimerized single-domain antibodies that bind ror1
GEAP202616877A (en) * 2023-06-06 2026-03-25 Biocad Joint Stock Co Monoclonal antibody or antigen-binding fragment thereof that specifically binds to axl, and use thereof
WO2025042968A1 (en) * 2023-08-22 2025-02-27 Integral Molecular, Inc. Compositions and methods related to chicken recombinant heavy-chain only antibodies
PL446349A1 (pl) * 2023-10-11 2025-04-14 Celon Pharma Spółka Akcyjna Przeciwciała bispecyficzne anty-AXL i anty-PD-L1 oraz ich zastosowanie w terapii, zwłaszcza w leczeniu nowotworu
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2012273955A1 (en) 2011-06-22 2014-01-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-Axl antibodies and uses thereof
WO2012175691A1 (en) * 2011-06-22 2012-12-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl antibodies and uses thereof
DK3169706T3 (da) * 2014-07-11 2020-03-09 Genmab As Antistoffer, der binder axl
WO2016187354A1 (en) * 2015-05-18 2016-11-24 Agensys, Inc. Antibodies that bind to axl proteins
CA2991805A1 (en) * 2015-07-10 2017-01-19 Genmab A/S Axl-specific antibody-drug conjugates for cancer treatment

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