KR20200067145A - Axl-특이적 항체 및 그의 용도 - Google Patents

Axl-특이적 항체 및 그의 용도 Download PDF

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KR20200067145A
KR20200067145A KR1020207010151A KR20207010151A KR20200067145A KR 20200067145 A KR20200067145 A KR 20200067145A KR 1020207010151 A KR1020207010151 A KR 1020207010151A KR 20207010151 A KR20207010151 A KR 20207010151A KR 20200067145 A KR20200067145 A KR 20200067145A
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ser
seq
thr
antibody
gly
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케빈 헨리
마리아 루즈 자라밀로
콜린 로저 메켄지
안 마르실
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내셔날 리서치 카운실 오브 캐나다
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/68031Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being an auristatin
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
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KR1020207010151A 2017-09-13 2018-09-10 Axl-특이적 항체 및 그의 용도 Ceased KR20200067145A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762557870P 2017-09-13 2017-09-13
US62/557,870 2017-09-13
PCT/CA2018/051108 WO2019051586A1 (en) 2017-09-13 2018-09-10 AXL SPECIFIC ANTIBODIES AND USES THEREOF

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KR20200067145A true KR20200067145A (ko) 2020-06-11

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US (2) US11739154B2 (OSRAM)
EP (1) EP3681912A4 (OSRAM)
JP (1) JP7366886B2 (OSRAM)
KR (1) KR20200067145A (OSRAM)
CN (1) CN111263770A (OSRAM)
AU (1) AU2018333290A1 (OSRAM)
BR (1) BR112020005011A2 (OSRAM)
CA (1) CA3075531A1 (OSRAM)
IL (1) IL273157A (OSRAM)
RU (1) RU2020113027A (OSRAM)
SG (1) SG11202002331QA (OSRAM)
WO (1) WO2019051586A1 (OSRAM)

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JP7356351B2 (ja) 2016-12-12 2023-10-04 エクセラ・バイオサイエンシーズ・インコーポレイテッド マイクロキャピラリーアレイを使用したスクリーニングのための方法およびシステム
EP3562796B1 (en) 2016-12-30 2023-04-19 Xcella Biosciences, Inc. Multi-stage sample recovery system
ES2987081T3 (es) 2018-12-06 2024-11-13 Xcella Biosciences Inc Carga lateral de arreglos de microcapilares
CN113045664B (zh) * 2019-11-28 2023-05-12 尚健单抗(北京)生物技术有限公司 一种分离的结合抗原axl的蛋白及其用途
WO2021154156A1 (en) * 2020-01-31 2021-08-05 Agency For Science, Technology And Research Anti-axl antibody and uses thereof
EP4092051A4 (en) * 2020-06-18 2023-09-06 Shenzhen Mindray Bio-Medical Electronics Co., Ltd SOLUBLE ANTI-SUBTYPE CD14 ANTIBODY, KIT AND CORRESPONDING USE
CN115125272B (zh) * 2021-03-29 2024-04-19 复旦大学 一种car-t治疗载体及其构建方法和应用
AU2021451307A1 (en) * 2021-06-16 2024-02-01 Shanghai Sinobay Biotechnology Co., Ltd. Antibody targeting axl protein and antigen binding fragment thereof, preparation method therefor and use thereof
AU2024284408A1 (en) * 2023-06-06 2025-12-18 Joint Stock Company "Biocad" Monoclonal antibody or antigen-binding fragment thereof that specifically binds to axl, and use thereof
WO2025042968A1 (en) * 2023-08-22 2025-02-27 Integral Molecular, Inc. Compositions and methods related to chicken recombinant heavy-chain only antibodies
PL446349A1 (pl) * 2023-10-11 2025-04-14 Celon Pharma Spółka Akcyjna Przeciwciała bispecyficzne anty-AXL i anty-PD-L1 oraz ich zastosowanie w terapii, zwłaszcza w leczeniu nowotworu
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

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JP6033293B2 (ja) * 2011-06-22 2016-11-30 インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル)Inserm(Institut National Dela Sante Et De La Recherche Medicale) 抗Axl抗体及びその使用
KR20140104945A (ko) 2011-06-22 2014-08-29 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 항-axl 항체 및 그의 용도
HRP20200283T1 (hr) 2014-07-11 2020-05-29 Genmab A/S Protutijela koja se vežu na axl
WO2016187354A1 (en) * 2015-05-18 2016-11-24 Agensys, Inc. Antibodies that bind to axl proteins
SMT202000359T1 (it) 2015-07-10 2020-09-10 Genmab As Coniugati anticorpo-farmaco specifici per axl per il trattamento del cancro

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US20200277386A1 (en) 2020-09-03
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