KR20200064319A - Composition for skin anti-wrinkle comprising mixture of Ulmus davidiana var. japonica extract and Cornus officinalis extract as effective component - Google Patents
Composition for skin anti-wrinkle comprising mixture of Ulmus davidiana var. japonica extract and Cornus officinalis extract as effective component Download PDFInfo
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- KR20200064319A KR20200064319A KR1020180150324A KR20180150324A KR20200064319A KR 20200064319 A KR20200064319 A KR 20200064319A KR 1020180150324 A KR1020180150324 A KR 1020180150324A KR 20180150324 A KR20180150324 A KR 20180150324A KR 20200064319 A KR20200064319 A KR 20200064319A
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- cornus officinalis
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
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Abstract
Description
본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 조성물에 관한 것이다. The present invention relates to a composition for improving skin wrinkles containing a mixture of elm and cornus officinalis as an active ingredient.
피부 노화는 나이가 들어가면서 피부에 나타나게 되는 유형과 무형상의 변화를 통틀어 일컫는다. 피부노화는 연령이 증가함에 따라 생체의 생리적인 기능이 저하되어 자연적으로 유발되는 내인성 생리적 노화와 장기간 자외선 노출에 의해 진행되는 외인성 광노화(photoaging)로 구분될 수 있다. 내인성 피부 노화의 임상적 특징은 피부가 얇아지고, 탄력성이 감소하는 것이다. 또한, 조직학적 소견으로는, 표피 및 진피의 두께가 얇아지고, 혈관이 감소되며, 진피 내의 섬유아세포의 수가 감소하게 되는 것이다. 또한, 외인성 피부 노화인 광노화의 임상적 특징은, 피부가 거칠고 탄력성이 없어지며, 불규칙한 색소 침착이 발생되고, 깊은 주름살이 증가되는 것이다. Skin aging refers to both the type and intangible changes that appear on the skin with age. Skin aging may be divided into endogenous physiological aging, which is naturally caused by an increase in physiological function of a living body as age increases, and exogenous photoaging, which is caused by long-term UV exposure. The clinical feature of endogenous skin aging is that the skin becomes thinner and the elasticity decreases. In addition, histological findings are that the thickness of the epidermis and dermis is thinned, blood vessels are reduced, and the number of fibroblasts in the dermis is reduced. In addition, the clinical characteristics of photoaging, which is exogenous skin aging, is that the skin becomes rough and elastic, irregular pigmentation occurs, and deep wrinkles increase.
주름의 생성 원인으로는 여러 가지가 보고되고 있는데, 우선 피부가 과다한 자외선에 노출되면 피부 구성성분인 콜라겐(collagen) 분해가 촉진되어 피부가 탄력을 잃고 주름이 생성될 수 있다. 또한, 피부가 과도한 온도변화 및 습도저하나 바람 등에 의해 지나치게 건조해지면 외부에 대한 방어벽으로서의 피부 기능이 저하되어 주름이 생기기도 한다. 그리고 피부가 활성 산소종이나 자유 라디칼에 노출되면 산화 작용에 의해 과산화 지질이 생성되고 그로 인해 콜라겐 등의 피부 구성 단백질이 변형되어 주름이 생성될 수 있다. 이러한 외부적 요인과 내부적 요인에 의한 주름 발생을 억제하고자 다양한 화장품 조성물이 연구되고 있다. 특히 화학성분이 함유된 기능성 화장품의 경우, 피부 자극을 유발하여 민감성 피부에 적합하지 않은 문제점이 있는 바, 피부에 자극이 적고 친환경적인 천연 식물 유래의 기능성 화장품에 대한 관심이 집중되고 있다.Various causes of wrinkles have been reported. First, when the skin is exposed to excessive ultraviolet rays, collagen, which is a skin component, is accelerated, and thus the skin loses elasticity and wrinkles may be generated. In addition, if the skin becomes excessively dry due to excessive temperature change, low humidity, or wind, the skin function as a barrier to the outside is deteriorated and wrinkles may occur. In addition, when the skin is exposed to free radicals or free radicals, lipid peroxide is generated by oxidizing action, and thus, skin constituent proteins such as collagen are deformed and wrinkles may be generated. Various cosmetic compositions have been studied to suppress wrinkles caused by external factors and internal factors. In particular, in the case of functional cosmetics containing chemical components, there is a problem that it is not suitable for sensitive skin by causing skin irritation, and attention is focused on functional cosmetics derived from natural plants that have little irritation to the skin and are environmentally friendly.
한편, 주름개선 효과와 관련된 선행기술로는 한국등록특허 제1574558호에 진세노사이드 Rd, Rb2와 죽여 추출물을 유효성분으로 함유하는 주름개선 및 보습용 화장료 조성물이 개시되어 있고, 한국등록특허 제1574248호에 왕호장 추출물을 유효성분으로 함유하는 피부 주름개선용 화장료 조성물이 개시되어 있지만, 본 발명의 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 조성물에 관해 개시된 바 없다. On the other hand, as a prior art related to the wrinkle improvement effect, Korean Registered Patent No. 1574558 discloses a cosmetic composition for wrinkle improvement and moisturizing containing ginsenoside Rd, Rb2 and killing extract as an active ingredient, and Korean Patent Registration No. 1574248 Although a cosmetic composition for improving skin wrinkles containing an extract of Wang Ho Jang Jang as an active ingredient is disclosed, a composition for improving skin wrinkles containing a mixture of elm and cornus extract of the present invention as an active ingredient has not been disclosed.
본 발명은 상기와 같은 요구에 의해 도출된 것으로, 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 조성물을 제공하고, 상기 느릅나무 추출물 및 산수유 추출물의 혼합물이 느릅나무 추출물 또는 산수유 추출물 단독에 비해 주름개선효과가 증진되는 것을 확인함으로써, 본 발명을 완성하였다. The present invention was derived by the above-described needs, and provides a composition for improving skin wrinkles containing a mixture of elm and cornus extract as an active ingredient, wherein the mixture of elm extract and cornus extract is elm extract or cornus By confirming that the wrinkle improvement effect is enhanced compared to the extract alone, the present invention was completed.
상기 과제를 해결하기 위하여, 본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 화장료 조성물을 제공한다.In order to solve the above problems, the present invention provides a cosmetic composition for improving skin wrinkles containing a mixture of elm and cornus officinalis as an active ingredient.
또한, 본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 건강기능식품 조성물을 제공한다. In addition, the present invention provides a health functional food composition for improving skin wrinkles containing a mixture of elm and cornus extract as an active ingredient.
본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 조성물에 관한 것으로, 느릅나무 및 산수유 추출물의 혼합물은 느릅나무 추출물 또는 산수유 추출물 개별 물질에 비해 콜라겐분해효소 활성을 억제하는 효과가 현저하므로, 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 본 발명의 조성물은 피부 주름개선용 화장료 조성물 또는 피부 주름개선용 건강기능식품 조성물로 사용될 수 있다. The present invention relates to a composition for improving skin wrinkles containing a mixture of elm and cornus extract as an active ingredient, wherein a mixture of elm and cornus extract extract inhibits collagenase activity compared to elm extract or cornus extract individual substances Since the effect is remarkable, the composition of the present invention containing a mixture of elm and cornus officinalis extracts as an active ingredient may be used as a cosmetic composition for improving skin wrinkles or a health functional food composition for improving skin wrinkles.
도 1은 느릅나무 추출물 또는 산수유 추출물의 세포독성을 확인한 결과이다. Control은 추출물 무처리군이다.
도 2는 느릅나무 추출물 또는 산수유 추출물의 콜라겐분해효소(collagenase) 활성 억제 효과를 확인한 결과이다. Control은 클로스트리듐 히스톨리티쿰(Clostridium histolyticum)에서 추출된 콜라겐분해효소만 처리한 음성대조군이고, MI는 클로스트리듐 히스톨리티쿰(Clostridium histolyticum)에서 추출된 콜라겐분해효소 및 금속단백질분해효소 억제제(Metalloprotease inhibitor)를 처리한 양성대조군이다. 1 is a result confirming the cytotoxicity of elm extract or cornus extract. Control is an extract-free group.
2 is a result confirming the inhibitory effect of the collagen decomposition enzyme (collagenase) activity of elm extract or cornus extract. Control is a negative control treated only with collagenase extracted from Clostridium histolyticum , MI is Clostridium histolyticum ) is a positive control treated with collagenase and metalloprotease inhibitor.
본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 화장료 조성물에 관한 것이다. The present invention relates to a cosmetic composition for improving skin wrinkles containing a mixture of elm and cornus officinalis extracts as an active ingredient.
본 발명의 일 구현 예에서, 본 발명의 화장료 조성물은 당업계에서 통상적으로 제조되는 어떠한 제형으로도 제조될 수 있으며, 예를 들어, 용액, 현탁액, 유탁액, 페이스트, 겔, 크림, 로션, 파우더, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션 및 스프레이 등으로 제형화될 수 있고, 보다 상세하게는, 스킨, 스킨 소프트너, 스킨토너, 아스트린젠트, 로션, 밀크로션, 모이스쳐로션, 영양로션, 마사지크림, 영양크림, 아이 크림, 모이스쳐 크림, 핸드크림, 에센스, 영양에센스, 팩, 클렌징폼, 클렌징 워터, 클렌징 로션, 클렌징 크림, 바디로션, 바디클렌져, 비누 및 파우더의 화장품 제형으로 제조될 수 있으나 이에 한정하는 것은 아니다. In one embodiment of the present invention, the cosmetic composition of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders , Oil, powder foundation, emulsion foundation, wax foundation and spray, etc., and more specifically, skin, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutrition lotion, massage Cream, nourishing cream, eye cream, moisturizing cream, hand cream, essence, nutrition essence, pack, cleansing foam, cleansing water, cleansing lotion, cleansing cream, body lotion, body cleanser, soap and powder can be prepared in cosmetic formulations, It is not limited to this.
본 발명의 화장료 조성물의 제형이 페이스트, 크림 또는 겔인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. This can be used.
본 발명의 화장료 조성물의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로 히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the cosmetic composition of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in the case of a spray, additionally chlorofluorohydro Propellants such as carbon, propane/butane or dimethyl ether.
본 발명의 화장료 조성물의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되고, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 있다.When the formulation of the cosmetic composition of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, and propylene Glycols, 1,3-butylglycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan.
본 발명의 화장료 조성물의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the cosmetic composition of the present invention is a suspension, a liquid diluent such as water, ethanol or propylene glycol as a carrier component, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester , Microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or trakant, and the like.
본 발명의 화장료 조성물에는 상기 유효성분 이외에 화장품 조성물에 통상적으로 이용되는 성분들을 포함하며, 예컨대 지방 물질, 유기 용매, 용해제, 농축제 및 겔화제, 연화제, 항산화제, 현탁화제, 안정화제, 발포제(foaming agent), 방향제, 계면활성제, 물, 이온형 또는 비이온형 유화제, 충전제, 금속이온 봉쇄제 및 킬레이트화제, 보존제, 비타민, 차단제, 습윤화제, 필수 오일, 염료, 안료, 친수성 또는 친유성 활성제, 지질 소낭과 같은 통상적인 보조제, 그리고 담체를 포함한다.The cosmetic composition of the present invention includes components commonly used in cosmetic compositions in addition to the above-mentioned active ingredients, for example, fatty substances, organic solvents, solubilizers, thickeners and gelling agents, emollients, antioxidants, suspending agents, stabilizers, blowing agents ( foaming agents), fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers, metal ion blockers and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives , Conventional adjuvants such as lipid vesicles, and carriers.
본 발명은 느릅나무 및 산수유 추출물의 혼합물을 유효성분으로 함유하는 피부 주름개선용 건강기능식품 조성물에 관한 것이다. The present invention relates to a health functional food composition for improving skin wrinkles containing a mixture of elm and cornus officinalis extracts as an active ingredient.
상기 건강기능식품 조성물은 분말, 과립, 환, 정제, 캡슐, 캔디, 시럽 및 음료의 제형으로 제조할 수 있으나 이에 제한되지 않는다. The health functional food composition may be prepared in the form of powder, granule, pill, tablet, capsule, candy, syrup and beverage, but is not limited thereto.
본 발명의 건강기능식품 조성물을 식품첨가물로 사용하는 경우, 상기 건강기능식품 조성물을 그대로 첨가하거나 다른 식품 또는 식품성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분의 양은 그의 사용 목적에 따라 적절하게 사용될 수 있다. 일반적으로, 식품 또는 음료의 제조시 본 발명의 건강기능식품 조성물은 원료에 대하여 15 중량부 이하, 바람직하게는 10 중량부 이하의 양으로 첨가된다. 그러나 건강을 목적으로 장기간 섭취하는 경우에는 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없는 범위 내에서 상기 범위 이상의 양으로 사용될 수 있다.When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is or used with other foods or food ingredients, and may be suitably used according to a conventional method. The amount of the active ingredient can be suitably used depending on the purpose of its use. In general, the health functional food composition of the present invention in the manufacture of food or beverage is added in an amount of 15 parts by weight or less, preferably 10 parts by weight or less with respect to the raw material. However, when ingested for a long period of time for health purposes, the amount may be below the above range, and may be used in an amount above the above range within a range where there is no problem in terms of safety.
상기 건강기능식품의 종류에 특별한 제한은 없다. 상기 건강기능식품 조성물을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다.There are no particular restrictions on the type of the health functional food. Examples of foods to which the health functional food composition can be added are meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gum products, dairy products including ice cream, various soups, beverages, tea Drinks, alcoholic beverages, and vitamin complexes are included, and all foods in the ordinary sense are included.
또한, 본 발명의 건강기능식품 조성물은 식품, 특히 기능성 식품으로 제조될 수 있다. 본 발명의 기능성 식품은 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함한다. 예컨대, 드링크제로 제조되는 경우에는 유효성분 이외에 천연 탄수화물 또는 향미제를 추가 성분으로서 포함시킬 수 있다. 상기 천연 탄수화물은 모노사카라이드(예컨대, 글루코오스, 프럭토오스 등), 디사카라이드(예컨대, 말토스, 수크로오스 등), 올리고당, 폴리사카라이드(예컨대, 덱스트린, 시클로덱스트린 등) 또는 당알코올(예컨대, 자일리톨, 소르비톨, 에리쓰리톨 등)인 것이 바람직하다. 상기 향미제는 천연 향미제(예컨대, 타우마틴, 스테비아 추출물 등)와 합성 향미제(예컨대, 사카린, 아스파르탐 등)를 이용할 수 있다.In addition, the health functional food composition of the present invention may be prepared as a food, particularly a functional food. The functional food of the present invention includes ingredients that are conventionally added during food production, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, when prepared as a drink agent, natural carbohydrates or flavoring agents may be included as additional components in addition to the active ingredient. The natural carbohydrates include monosaccharides (e.g. glucose, fructose, etc.), disaccharides (e.g. maltose, sucrose, etc.), oligosaccharides, polysaccharides (e.g. dextrins, cyclodextrins, etc.) or sugar alcohols (e.g. , Xylitol, sorbitol, erythritol, and the like). The flavoring agent may be a natural flavoring agent (eg, tau martin, stevia extract, etc.) and a synthetic flavoring agent (eg, saccharin, aspartame, etc.).
상기 건강기능식품 조성물 이외에 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등을 더 함유할 수 있다.
Various nutritional supplements, vitamins, electrolytes, flavoring agents, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohol, carbonic acid, in addition to the above-mentioned health functional food composition It may further contain a carbonation agent used in the beverage.
이하, 실시예를 이용하여 본 발명을 더욱 상세하게 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로 본 발명의 범위가 이들에 의해 제한되지 않는다는 것은 당해 기술분야에서 통상의 지식을 가진 자에게 있어 자명한 것이다.
Hereinafter, the present invention will be described in more detail using examples. It is obvious to those skilled in the art that these examples are only intended to illustrate the present invention in more detail and that the scope of the present invention is not limited by them.
실시예Example 1. 느릅나무 추출물 및 산수유 추출물의 세포독성 1. Cytotoxicity of elm extract and Cornus officinalis extract
느릅나무 추출물 및 산수유 추출물 시료의 안정성을 알아보기 위해 MTS(3-(4,5-디메틸티아졸-2-일)-5-(3-카르복시메톡시페닐)-2-(4-설포페닐)-2H-테트라졸리움, promega, USA) 분석 방법을 통해 인간 신장 상피 세포인 293T 세포의 생존율을 측정하였다. MTS(3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl) for the stability of elm extract and cornus extract samples -2H-tetrazolium, promega, USA) was analyzed to measure the survival rate of 293T cells, human kidney epithelial cells.
세포를 96 웰 플레이트에 4x103 세포/웰 씩 분주한 다음 농도별(10, 50, 100㎍/㎖)로 시료를 처리하여 37℃, 5% CO2 조건으로 48시간 동안 배양하였다. 배양 후 2mg/㎖의 농도로 PBS에 희석된 MTS 용액 20㎕를 첨가하고 4시간 동안 재배양한 후 마이크로플레이트 리더로 490nm에서 흡광도를 측정하였다. 세포의 생존능력은 다음의 식에 따라 계산하였다.Cells were divided into 4x10 3 cells/well in a 96-well plate, and then treated with samples according to concentration (10, 50, 100 µg/ml), and cultured at 37°C and 5% CO 2 for 48 hours. After incubation, 20 μl of the MTS solution diluted in PBS at a concentration of 2 mg/ml was added, and cultured for 4 hours, and absorbance was measured at 490 nm with a microplate reader. Cell viability was calculated according to the following equation.
[식 1][Equation 1]
세포 생존율(%)=시료 첨가군의 흡광도/대조군의 흡광도×100Cell viability (%) = absorbance of the sample-added group/absorbance of the control group x 100
그 결과, 도 1에 개시된 바와 같이 느릅나무 추출물 및 산수유 추출물은 모두 세포독성이 없는 것을 확인하였다.
As a result, it was confirmed that the elm extract and cornus officinalis extract are not cytotoxic, as disclosed in FIG. 1.
실시예Example 2. 느릅나무 추출물 및 산수유 추출물의 콜라겐분해효소(collagenase) 활성 억제 효과 2. Inhibition effect of collagenase activity of elm extract and Cornus officinalis extract
느릅나무 추출물 및 산수유 추출물의 콜라겐분해효소 활성 억제효과를 확인하기 위해 EnzChek 콜라겐분해효소 분석 키트(Molecular Probes Inc.)를 사용하였다. 클로스트리듐 히스톨리티쿰(Clostridium histolyticum)에서 추출된 콜라겐분해효소의 활성 억제 효과는 효소, 기질 및 농도별 느릅나무 추출물, 산수유 추출물 또는 이들의 혼합물을 1~2시간 동안 반응시킨 후 형광플레이트리더기(Ex/Em:495/515nm)를 사용하여 흡광도를 측정하여 확인하였다. 효소 단독 처리군은 대조군(control)으로 사용하였다. An EnzChek collagenase analysis kit (Molecular Probes Inc.) was used to confirm the inhibitory effect of elm extract and cornus officinalis on collagenase activity. Clostridium Histolyticum ) has the effect of inhibiting the activity of collagen degrading enzyme extracted from enzymes, substrates and concentrations of elm extract, cornus officinalis extract or mixtures thereof for 1 to 2 hours, followed by fluorescence plate reader ( Ex/Em :495/515nm) It was confirmed by measuring the absorbance. The enzyme-only treatment group was used as a control.
그 결과, 도 2에 개시된 바와 같이 느릅나무 추출물은 10, 50 및 100㎍/㎖에서 농도 의존적으로 콜라겐분해효소 활성 억제 효과가 있었고, 산수유 추출물은 10㎍/㎖에서는 콜라겐분해효소 활성 억제 효과가 거의 없었으나, 50 및 100㎍/㎖로 처리한 경우 농도 의존적으로 콜라겐분해효소 활성 억제 효과가 나타나는 것을 확인하였다. As a result, as shown in FIG. 2, the elm extract had a concentration-dependent inhibitory effect on collagenase activity at 10, 50, and 100 μg/ml, and the cornus extract had almost no inhibitory effect on collagenase activity at 10 μg/ml. However, when treated with 50 and 100㎍ / ㎖ it was confirmed that the concentration-dependent inhibitory effect of collagenase activity.
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