KR20200060456A - 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료 - Google Patents

완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료 Download PDF

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KR20200060456A
KR20200060456A KR1020207011989A KR20207011989A KR20200060456A KR 20200060456 A KR20200060456 A KR 20200060456A KR 1020207011989 A KR1020207011989 A KR 1020207011989A KR 20207011989 A KR20207011989 A KR 20207011989A KR 20200060456 A KR20200060456 A KR 20200060456A
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antigen
cells
binding fragment
seq
human subject
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Korean (ko)
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스테판 유
리키 로버트 레인하트
에버렌 쉐리 반
카렌 프란 코자르스키
큐랜 매튜 심슨
주춘 우
피터 앤소니 캄포치아로
지쿠이 쉔
쿤 딩
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리젠엑스바이오 인크.
더 존스 홉킨스 유니버시티
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Priority to KR1020257008245A priority Critical patent/KR20250040754A/ko
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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KR1020207011989A 2017-09-27 2018-09-26 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료 Ceased KR20200060456A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257008245A KR20250040754A (ko) 2017-09-27 2018-09-26 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201762564095P 2017-09-27 2017-09-27
US62/564,095 2017-09-27
US201762574657P 2017-10-19 2017-10-19
US62/574,657 2017-10-19
US201762579682P 2017-10-31 2017-10-31
US62/579,682 2017-10-31
US201862632812P 2018-02-20 2018-02-20
US62/632,812 2018-02-20
PCT/US2018/052855 WO2019067540A1 (en) 2017-09-27 2018-09-26 TREATMENT OF OCULAR DISEASES WITH A TOTALLY HUMAN POST-TRANSLATIONAL MODIFICATION ANTI-VEGF FAB

Related Child Applications (1)

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KR1020257008245A Division KR20250040754A (ko) 2017-09-27 2018-09-26 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료

Publications (1)

Publication Number Publication Date
KR20200060456A true KR20200060456A (ko) 2020-05-29

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KR1020207011989A Ceased KR20200060456A (ko) 2017-09-27 2018-09-26 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료
KR1020257008245A Pending KR20250040754A (ko) 2017-09-27 2018-09-26 완전-인간 번역후 변형된 항-VEGF Fab를 이용한 안구 질환의 치료

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US (3) US20200277364A1 (https=)
EP (1) EP3687464A4 (https=)
JP (2) JP7685833B2 (https=)
KR (2) KR20200060456A (https=)
AU (2) AU2018342094B2 (https=)
CA (1) CA3076905A1 (https=)
IL (1) IL273403A (https=)
SG (1) SG11202002396TA (https=)
WO (1) WO2019067540A1 (https=)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX373894B (es) 2012-11-08 2020-07-09 Clearside Biomedical Inc Métodos y dispositivos para el tratamiento de trastornos oculares en sujetos humanos.
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
KR20250057128A (ko) 2015-12-30 2025-04-28 코디악 사이언시스 인코포레이티드 항체 및 이의 접합체
SG11201808426XA (en) 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
EP3727468A4 (en) 2017-12-19 2021-09-22 Akouos, Inc. AAV-MEDIATED THERAPEUTIC ANTIBODIES DELIVERY TO THE INTERNAL EAR
US12558434B2 (en) 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
EP3758737A4 (en) 2018-03-02 2022-10-12 Kodiak Sciences Inc. IL-6 ANTIBODIES AND FUSION CONSTRUCTS AND CONJUGATES THEREOF
US20220133908A1 (en) * 2019-02-08 2022-05-05 Curevac Ag Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases
WO2020206098A1 (en) * 2019-04-03 2020-10-08 Regenxbio Inc. Gene therapy for eye pathologies
EP3886946A1 (en) 2019-06-05 2021-10-06 Regeneron Pharmaceuticals, Inc. Devices and methods for precision dose delivery
CN110423281B (zh) * 2019-07-31 2021-04-30 成都金唯科生物科技有限公司 用于治疗老年性黄斑变性的融合蛋白、病毒载体和药物
CN114502197A (zh) * 2019-08-26 2022-05-13 再生生物股份有限公司 用全人经翻译后修饰的抗VEGF Fab治疗糖尿病性视网膜病变
WO2021071835A1 (en) 2019-10-07 2021-04-15 Regenxbio Inc. Adeno-associated virus vector pharmaceutical composition and methods
CA3157509A1 (en) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Methods of treating an eye disorder
WO2021188803A1 (en) * 2020-03-19 2021-09-23 Clearside Biomedical, Inc. Compositions and methods for treating ocular disorders
JP2023535632A (ja) 2020-07-27 2023-08-18 アンジャリウム バイオサイエンシズ エージー Ｄｎａ分子の組成物、その作製方法、及びその使用方法
CA3198368A1 (en) * 2020-10-07 2022-04-14 Regenxbio Inc. Formulations for suprachoroidal administration such as formulations with aggregate formation
IL303317A (en) 2020-12-01 2023-07-01 Akouos Inc ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA
WO2022165313A1 (en) 2021-02-01 2022-08-04 Regenxbio Inc. Gene therapy for neuronal ceroid lipofuscinoses
MX2024003320A (es) * 2021-09-18 2024-06-28 Skyline Therapeutics Ltd Virus adenoasociado para terapia génica de degeneración macular húmeda asociada con la edad.
CN116925234B (zh) * 2022-04-02 2024-05-31 合肥星眸生物科技有限公司 一种编码抗vegf-a和ang-2双特异性抗体的aav载体
IL319873A (en) 2022-09-30 2025-05-01 Regenxbio Inc Treatment of eye diseases with recombinant viral vectors containing anti-VEGF FAB
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6943153B1 (en) * 1999-03-15 2005-09-13 The Regents Of The University Of California Use of recombinant gene delivery vectors for treating or preventing diseases of the eye
US20070202186A1 (en) * 2006-02-22 2007-08-30 Iscience Interventional Corporation Apparatus and formulations for suprachoroidal drug delivery
SG176202A1 (en) * 2009-05-28 2011-12-29 Glaxo Group Ltd Combination of a tnf-alpha antagonist and a vegf antagonist for use in the treatment or prevention of diseases of the eye.
EP2443150B1 (en) * 2009-06-17 2015-01-21 AbbVie Biotherapeutics Inc. Anti-vegf antibodies and their uses
EP2559443A1 (en) * 2011-08-16 2013-02-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of an ocular disease in a subject
TWI698240B (zh) * 2012-05-15 2020-07-11 澳大利亞商艾佛蘭屈澳洲私營有限公司 使用腺相關病毒(aav)sflt-1治療老年性黃斑部退化(amd)
CA2922483A1 (en) * 2013-09-11 2015-03-19 Neurotech Usa, Inc. Encapsulated cell therapy cartridge
US10064752B2 (en) * 2014-09-11 2018-09-04 Orbit Biomedical Limited Motorized suprachoroidal injection of therapeutic agent
CA3010862A1 (en) * 2016-01-08 2017-07-13 Clearside Biomedical, Inc. Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics
KR20240005973A (ko) * 2016-04-15 2024-01-12 리젠엑스바이오 인크. 완전히-인간형의 번역후 변형된 항-VEGF Fab를 이용한 눈 질환의 치료
SG11201808426XA (en) * 2016-04-15 2018-10-30 Univ Pennsylvania Compositions for treatment of wet age-related macular degeneration
US12558434B2 (en) * 2018-02-20 2026-02-24 The Trustees Of The University Of Pennsylvania Compositions for treatment of wet age-related macular degeneration
WO2021188803A1 (en) * 2020-03-19 2021-09-23 Clearside Biomedical, Inc. Compositions and methods for treating ocular disorders

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JP2020535184A (ja) 2020-12-03
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KR20250040754A (ko) 2025-03-24
US20200277364A1 (en) 2020-09-03
EP3687464A4 (en) 2021-09-29
JP7685833B2 (ja) 2025-05-30
SG11202002396TA (en) 2020-04-29
AU2018342094B2 (en) 2025-02-06
WO2019067540A1 (en) 2019-04-04
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