KR20200053718A - Blood diagnostic apparatus - Google Patents

Abstract

Disclosed is a blood diagnostic device easy to use. According to the present invention, the blood diagnostic device comprises: a stage unit receiving a specimen plate for diagnosing infection of diseases thereon, wherein the specimen plate is smeared by blood to be diagnosed; a light radiation unit disposed on the lower side of the stage unit to radiate diagnosis light to the blood placed at a diagnosis position, of the blood smeared on the specimen plate; an image acquisition unit disposed on the upper side of the light radiation unit to acquire a diagnosis target image of the blood for a portion, to which the light is radiated by the light radiation unit, of the blood smeared on the specimen plate; an optical system disposed between the stage unit and the image acquisition unit and including a first magnification lens unit with a first magnification and a second magnification lens unit with a second magnification to acquire diagnosis target images with different magnifications; a horizontal moving unit horizontally moving the stage unit having the specimen plate received thereon to allow the image acquisition unit to acquire the diagnosis target image for the blood smeared on the specimen plate; and a control unit controlling a focal length of the optical system with respect to the blood smeared on the specimen plate to perform focusing, so as to execute a first image acquisition process of acquiring a low magnification diagnosis target image through the first magnification lens unit and a second image acquisition unit of acquiring a high magnification diagnosis target image through the second magnification lens unit.

Description

Blood diagnostic apparatus

The present invention relates to a blood diagnostic device, and relates to a blood diagnostic device for acquiring images of smeared blood and diagnosing disease infection.

 A blood diagnostic device is a device for examining whether a disease is infected by staining the blood and staining it, then observing the shape of blood cells or parasites under a microscope.

For example, malaria is an infection caused by malaria parasites invading red blood cells. When blood is stained and observed under a microscope, it is possible to determine whether malaria is infected because parasite nuclei are observed in red blood cells that do not have a nucleus. There will be.

In particular, when infected with parasitic diseases such as malaria, the rapid diagnostic test (RDT) and blood smear are usually used, and in the case of the rapid diagnostic method, a simple and rapid test is performed using a low-cost diagnostic kit. However, there is a problem that the accuracy is poor.

In addition, the blood smear method is a method in which a patient's blood is smeared on a slide and stained, and then the stained blood is observed and diagnosed under a microscope. Make a diagnosis.

However, such a conventional blood smear test requires a skilled expert, and has a problem that a mistake may occur in the process of smearing blood, and it takes a long time.

In addition, when observing and diagnosing with a microscope according to the blood smear method, there is a problem that it takes too long for a person to focus manually, and even if it focuses automatically, the lens moves to focus While silver is in nanometer or micrometer units, horizontal errors that can occur in the horizontality of slide glasses or smearing of blood, etc., have a problem that it takes a long time to automatically focus in millimeter units.

An object of the present invention is to provide a blood diagnostic device, and specifically, to provide a blood diagnostic device that automatically focuses and acquires an image of blood to diagnose whether a disease is infected.

The present invention was created in order to achieve the object of the present invention as described above, the stage 100 is mounted on the specimen plate 1 is plated with blood to be diagnosed for diagnosis of disease infection; A light irradiating unit 200 positioned at the lower side of the stage unit 100 to irradiate the diagnostic light to blood located at the diagnostic position among blood smeared on the specimen plate 1; An image acquisition unit 300 positioned on the upper side of the light irradiation unit 200 and obtaining a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiation unit 200; Located between the stage unit 100 and the image acquisition unit 300, the image acquisition unit 300 and the first magnification lens unit 410 having a first magnification to obtain a diagnosis target image of different magnification An optical system 400 including a second magnification lens unit 420 having a second magnification greater than 1 magnification; A horizontal moving unit 500 for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1 ; After performing the primary image acquisition process and the primary image acquisition process for acquiring the low-magnification diagnosis target image through the first magnification lens unit 410, the secondary for acquiring the high magnification diagnosis target image through the second magnification lens unit 420 Disclosed is a blood diagnostic apparatus comprising a control unit 600 for performing focusing by controlling a focal length of an optical system 400 for blood smeared on a sample plate 1 to perform an image acquisition process.

The control unit 600, based on the focal length of the first magnification lens unit 410 measured in the first image acquisition process, the diagnostic target blood within the depth (D1) of the first magnification lens unit 410 Focusing may be performed by controlling a focal length of the second magnification lens unit 420.

The light irradiation unit 200 may be installed to correspond to the first magnification lens unit 410 and the second magnification lens unit 420 of the optical system 400, respectively.

The control unit 600, when performing diagnosis on the blood smeared on each specimen plate 1, using an artificial intelligence module, the focal length Z corresponding to the measurement positions X and Y on the specimen plate 1 Learning the correlation with, and corresponding to the reference position X _n , Y _n of _n (n is a natural number greater than or equal to 2) preset on the sample plate 1 before performing diagnosis on blood smeared on the sample plate 1 sampling the focus distance Z _n, and the sampling results of the n X _n, Y _n, Z _n, and the sample plate (1) each X, the position X, Y, type Y coordinates through the pre-learning, artificial intelligence modules on the coordinate It is possible to obtain the estimated focal length Z at and control the focal length of the optical system 400 based on the obtained Z to perform focusing.

The control unit 600 acquires a primary image at the measurement position X and Y coordinates on the sample plate 1, checks the components in the blood in the measurement position from the obtained primary image, and based on the size of the components Focusing may be performed by controlling a focal length of the optical system 400.

The control unit 600 determines whether white blood cells are included in the composition of the blood from the primary image and, if white blood cells are included, controls the focal length of the optical system 400 based on the white blood cells to measure on the sample plate 1 After obtaining the first measurement image at the position X and Y coordinates, the second measurement image can be obtained at the measurement position X and Y coordinates on the specimen plate 1 by controlling the focal length of the optical system 400 based on the red blood cells. have.

The control unit 600 checks the components in the blood from the primary image, and controls the focal length of the optical system 400 based on the image of the preset region based on the location of the identified components to the components. It is possible to acquire a measurement image for.

Components in the blood from the primary image can be identified based on the color and size in the primary image.

The control unit 600 determines whether or not parasites are included in the composition of blood from the primary image, and if parasites are included, controls the focal length of the optical system 400 based on the size of the parasite before acquiring the first measurement image. The parasite measurement image can be obtained at the measurement positions X and Y coordinates on the sample plate 1.

Components in the blood from the primary image can be identified through an artificial intelligence module previously learned using the primary image.

The control unit 600 measures the focal length (Z _{n + 1} ) corresponding to the measurement positions X _{n + 1} and Y _{n + 1} on the sample plate ₁ in advance at the measurement positions X _n-1 and Y _{n-. It} is calculated based on the first equation calculated from the focal length (Z _n-1 ) corresponding to ₁ and the focal length (Z _n ) corresponding to the measurement positions X _n , Y _n , and the calculated focal length (Z _{n + 1)} ), Focusing may be performed by controlling the focal length of the optical system 400.

Disclosed is a blood diagnostic device characterized in that the diagnosis target disease of the blood diagnostic device is malaria.

The blood diagnostic device according to the present invention does not require an expert, and the user can easily use the blood diagnostic device, and has the advantage of being simpler and more accurate.

In addition, by using a dual-lens structure to automatically focus on blood, the diagnosis time can be shortened, and by using a high-magnification optical system, it has an advantage of obtaining a high-quality image.

In addition, in the process of focusing on blood, by using an artificial intelligence module or algorithm that can predict the focal length, it has an advantage of shortening the diagnosis time.

In addition, by focusing on whether red blood cells, white blood cells, or parasites are separated, it is possible to perform optimized focusing according to each object and to obtain a clearer image.

In addition, as the focal length is estimated, it is possible to easily correct the horizontal error that may occur in the device, thereby shortening the diagnosis time.

1 is a perspective view of a blood diagnostic device.
2 is a block diagram of the control unit of the blood diagnostic device.
3 is a side view of an embodiment of a blood diagnostic device.
4 is a conceptual diagram of the optical system of the blood diagnostic apparatus.
5 is an embodiment of a reference position for sampling the blood diagnostic device.
6 is a conceptual diagram for a method of performing focusing while being moved by a horizontal moving part in a blood diagnostic device.

Hereinafter, a blood diagnostic device according to the present invention will be described in detail with reference to the accompanying drawings.

The blood diagnostic apparatus according to the present invention comprises: a stage unit 100 on which a sample plate 1 on which blood to be diagnosed is mounted for diagnosis of disease infection; A light irradiating unit 200 positioned at the lower side of the stage unit 100 to irradiate the diagnostic light to blood located at the diagnostic position among blood smeared on the specimen plate 1; An image acquisition unit 300 positioned on the upper side of the light irradiation unit 200 and obtaining a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiation unit 200; An optical system 400 positioned between the stage unit 100 and the image acquisition unit 300 so that the image acquisition unit 300 acquires an image to be diagnosed; A horizontal moving unit 500 for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1 ; It includes a control unit 600 for controlling the image acquisition unit 300, the optical system 400 and the horizontal moving unit 500.

Specifically, the blood diagnostic device is a device that undergoes a series of procedures for diagnosing a disease infection by optically acquiring an image of blood by staining and smearing blood, and loading a test kit including a sample plate 1 It may include a body 11 on which the loading area 13 is formed and a display unit 12 for displaying the diagnosis process and results.

In addition, the blood diagnostic device may include a barcode recognition unit 14 capable of receiving barcode information including personal information of a patient displayed on the test kit, blood information, and the like.

In addition, the blood diagnostic device is preferably used to diagnose whether or not malaria infection.

The sample plate 1 is a configuration in which blood, which is the sample T, is settled, and various configurations are possible as long as it can be smeared after staining the blood. It may be shaped.

In addition, the specimen plate 1 may be composed of a test kit including a composition that can be smeared after staining the blood, and separate grooves can be formed to allow blood to be smeared at a constant height.

The stage unit 100 may be configured in a variety of configurations in which the sample plate 1 on which the blood to be diagnosed for the diagnosis of disease infection is mounted is settled.

Specifically, the stage unit 100, as a configuration for supporting the specimen plate 1 from the lower portion of the specimen plate 1, can seat the specimen plate 1, the front surface of the lower portion of the specimen plate (1) Although it may be a supporting configuration, it is preferable that the configuration that supports only the edge along the longitudinal direction of the sample plate 1 is a configuration in which light is irradiated by the lower light source.

The light irradiation unit 200 is located below the stage unit 100 and is configured to irradiate diagnostic light to blood located at a diagnostic position among blood smeared on the sample plate 1 and various configurations are possible.

Specifically, the light irradiation unit 200 may include a light source 210 composed of an LED or the like, and a light collection unit 220 for condensing light irradiated from the light source 210 and irradiating the specimen plate 1. .

The light source 210 is preferably white light, but the wavelength may be configured differently according to a configuration to be diagnosed in blood, and light may be irradiated by configuring colors differently.

In addition, the condenser 220 may include one or more condensing lenses 221 and converge to irradiate light to a position of an image to be acquired by the image acquisition unit 300 in correspondence with the optical system 400. Can be deployed.

The image acquisition unit 300 is located on the upper side of the light irradiation unit 200 and acquires a diagnosis target image of blood for a portion of blood smeared on the sample plate 1 by the light irradiation unit 200. Various configurations are possible.

Specifically, the image acquisition unit 300, it is preferable to include an image generating means such as an image sensor, such as CMOS, CCD, it is connected to the controller 600 to obtain an image.

The optical system 400, the image acquisition unit 300 in order to obtain the image to be diagnosed, the stage unit 100 and the image acquisition unit 300 is located between the configuration is possible various configurations.

Specifically, the optical system 400 may be configured to include an objective lens, an aperture, and an eyepiece, and the lenses are preferably formed of glass, but are made of various materials that can be imaged on the image acquisition unit 300. Can be implemented.

In addition, the optical system 400, while being controlled by the control unit 600 to be described later may cause the image acquisition unit 300 to form an image, the focal length itself changes by adjusting the distance between the lenses of the optical system 400 It may be a configuration.

In addition, the optical system 400, the distance between the lens is fixed, the focal length is constant, and the image acquisition unit 300 may be imaged through a distance change between the optical system 400 and the sample plate 1.

In addition, the optical system 400 may have various magnifications and may be configured as an enlarged magnification according to the purpose of blood diagnosis.

In particular, the optical system 400 may be configured to include a first magnification lens unit 410 having a first magnification and a second magnification lens unit 420 having a second magnification greater than the first magnification. , Acquiring a wide range of primary images using the first magnification lens unit 410, and using the second magnification lens unit having a second magnification greater than the first magnification to obtain a narrower, enlarged secondary image. Can be obtained.

When the objective lens comprises a first magnification lens unit 410 and a second magnification lens unit 420 having a second magnification greater than the first magnification, at least one of the light irradiation unit 200 and the image acquisition unit 300 The first magnification and the second magnification lens unit 410, 420 may be configured to be installed to correspond to each, the light irradiation unit 200 and the image acquisition unit 300, respectively, the first magnification and the second magnification lens unit The configuration corresponding to (410, 420) is preferred.

The horizontal moving part 500 horizontally moves the stage part 100 on which the sample plate 1 is seated so that the image acquiring part 300 can acquire a diagnosis target image for blood smeared on the sample plate 1. Various configurations are possible with the moving configuration.

Specifically, the horizontal moving part 500, it is preferable to horizontally move the stage part 100 so as to obtain an image to be diagnosed with respect to the entire range of blood smeared on the specimen plate 1, as shown in FIG. As shown, the stage unit 100 may be moved to obtain an image of blood in a zigzag manner along the longitudinal direction of the sample plate 1.

In addition, the horizontal moving part 500 may move the stage part 100 in the form of a conveyor using a motor or the like, and various configurations are possible in a configuration capable of horizontally moving the stage part 100.

The control unit 600, as shown in Figure 2, the display 12, the stage unit 100, the light irradiation unit 200, the image acquisition unit 300, the optical system 400, the horizontal moving unit 500 It may be a configuration that controls the overall.

In particular, the control unit 600 may be configured in a configuration that performs focusing so as to form an image acquisition unit 300 by controlling a focal length of the optical system 400.

In order to obtain a clear image in the optical system for acquiring the image of the object to be measured, the object to be measured must be located at a predetermined focal length of the objective lens, and the range recognized as focus is called depth.

The controller 600 may control the blood to be measured to be located within a depth range at a focal length of the objective lens.

Specifically, the control unit 600, in controlling the focal length of the optical system 400 to obtain an image of the blood in focus, first to the Z value in a wide range (R1) perpendicular to the specimen plate (1) The optical system 400 may be controlled on the basis of acquiring a focus value with respect to focusing again in a narrower range R2 in which the focus value is included.

Particularly, when the optical system 400 includes the first magnification lens unit 410 and the second magnification lens unit 420 having a second magnification greater than the first magnification, the control unit 600 is the first. The focal length of the optical system 400 can be controlled to obtain a faster and more accurate image of blood using the magnification lens unit 410 and the second magnification lens unit 420 having a second magnification greater than the first magnification. have.

Specifically, the control unit 600, after performing the first image acquisition process and the first image acquisition process to obtain a low magnification diagnosis target image through the first magnification lens unit 410 through the second magnification lens unit 420 The focal length of the optical system 400 for blood smeared on the sample plate 1 may be controlled in order to perform a secondary image acquisition process for obtaining a high magnification diagnosis target image.

Particularly, in performing the second image acquisition process, the controller 600 is configured to display the first magnification lens unit 410 based on the focal length of the first magnification lens unit 410 measured in the first image acquisition process. The focal length of the second magnification lens unit 420 for the blood to be diagnosed may be controlled within the depth D1.

The representative first focal length of the first magnification lens unit 410 may be the Z value, which is the focal length that is most focused in the first image acquisition process, and whether the focal point is the most suitable is the value obtained by converting the image data Can decide.

Specifically, the Z value, which is a focal length in which the focus is well focused, may be determined by extracting only a portion of signals using a high-pass filter and the RGB data obtained from the image sensor.

Since the depth of the second magnification lens unit 420 having the second magnification greater than the first magnification is shallower than the depth of the first magnification lens unit 410, the second magnification lens has a second magnification greater than the first magnification. The depth of the unit 420 exists within the depth of the first magnification lens unit 410, and focusing can be performed more quickly using the depth.

In addition, the control unit 600, between the first magnification lens unit 410 and the second magnification lens unit 410, the detection plate 1 on the stage unit 100 is disposed in parallel toward the detection plate 1 It can be controlled to move alternately.

Specifically, the second magnification lens unit 420 is controlled within the depth of the first magnification lens unit 410 while alternately moving between the first magnification lens unit 410 and the second magnification lens unit 420. It may be a configuration.

In addition, the control unit 600 may control the first magnification lens unit 410 and the second magnification lens unit 420 to alternately move toward the detection plate 1.

Specifically, the light irradiation unit 200 and the image acquisition unit 300 are arranged one by one, and the first magnification and second magnification lens units 410 and 420 are disposed together, so that only the objective lens is replaced, thereby displaying an image of blood. It may be a configuration to acquire.

In addition, the controller 600 may control the optical system 400 to obtain an estimated focal length Z by learning the focal length of the optical system 400 in focus with respect to the specimen plate 1 on the AI module. have.

Specifically, the control unit 600, when performing diagnosis on the blood smeared on each specimen plate 1, using an artificial intelligence module, the focal length corresponding to the measurement position X, Y on the specimen plate 1 Learning the correlation with (Z), and the reference positions X _n (n is a natural number of 2 or more) preset on the sample plate 1 before performing diagnosis on blood smeared on the sample plate 1 X _n , Y _n The focal length Z _n corresponding to is sampled, and each of the X and Y coordinates on the sample plate 1 and _n X _n , Y _n , Z _n , which is a sampling result, is input, and the corresponding position X is obtained through a pre-trained AI module. , It is possible to obtain the estimated focal length Z in the Y coordinate and control the focal length of the optical system 400 based on the obtained Z to perform focusing.

Specifically, the artificial intelligence module means a platform capable of learning and operating using a large amount of training data, such as Google's Deep Mind Lab, IBM's Watson, and the like.

In addition, the AI module performs statistical optimization by inputting the focal length Z corresponding to the X and Y coordinates parallel to the ground of the specimen plate 1, and is composed of an input layer, a hidden layer, and an output layer. , In the input layer, X and Y coordinates at a certain point of the sample plate 1 are input, and in the output layer, the focal length Z corresponding to the input value is output, and the hidden layer is an undisclosed layer between the input layer and the output layer. it means.

In addition, the artificial intelligence module used according to the embodiment of the present invention is a state in which learning has been completed through previous learning, and is set to an optimized value to form a predetermined correlation between input and output.

In addition, in estimating the focal length using the AI module after learning is completed, for accuracy, n preset values on the sample plate 1 (n is 2 or more) before performing diagnosis on blood smeared on the sample plate 1 The focal length Z _n corresponding to the reference position X _n , Y _n of a natural number) can be sampled and input.

The sampling may include Z corresponding to the X and Y coordinates of the center of the sample plate 1, preferably n is 4 or more, and the sampling is symmetrical with respect to the center of the sample plate 1 It is desirable to sample.

In addition, in order to obtain an ideally focused image, it is possible to obtain an image with high reliability by focusing again in a certain range based on Z obtained through the AI module.

In addition, the control unit 600 acquires the primary image at the measurement position X and Y coordinates on the sample plate 1, confirms the constituents in the blood in the measurement position from the obtained primary image, and determines the size of the constituents. As a reference, focusing may be performed by controlling a focal length of the optical system 400.

Specifically, in the case of malaria, parasites are infected by invading red blood cells, and malaria infection can be determined as the nuclei caused by parasites in red blood cells that do not have a nucleus, and accordingly, a clear image of red blood cells among substances in the blood It is possible to determine whether or not malaria is infected by obtaining. As there are many differences in size and thickness in the case of white blood cells and red blood cells, there is no choice but to differ in the focal length when focusing in the nano unit. Accordingly, the focal length of the optical system 400 is controlled differently.

In addition, the control unit 600 determines whether or not white blood cells are included in the composition of the blood from the primary image, and if white blood cells are included, the focal length of the optical system 400 is controlled based on the white blood cells to control the sample plate 1 After obtaining the first measurement image at the X and Y coordinates of the measurement position on the image, the focal length of the optical system 400 is controlled based on the red blood cells to obtain the second measurement image at the X and Y coordinates of the measurement position on the specimen plate 1 can do.

In addition, the control unit 600, as shown in Figure 5, checks the components in the blood from the primary image, and the optical system 400 based on the image of the preset region based on the location of the identified components By controlling the focal length of, it is possible to obtain a measurement image for the component.

This is for obtaining a highly reliable image of a diagnosis object, and obtaining a focal length for an image of a preset area based on the identified component position and feeding it back to control the focal length of the optical system 400. The slope, average value, etc. for the focal length of the set area can be used.

In addition, the components in the blood from the primary image may be identified based on the color and size in the primary image, and of course, may be identified using only one of the color and size.

In addition, the control unit 600 determines whether or not parasites are included in the composition of the blood from the primary image, and if parasites are included, the focal length of the optical system 400 is determined based on the size of the parasite before acquiring the first measurement image. By controlling, a parasite measurement image can be obtained at the measurement positions X and Y coordinates on the sample plate 1.

Specifically, since the thickness of the components differs depending on whether the components in the blood are red blood cells, white blood cells, or parasites, there may be a clear difference in controlling the focal length, and in the case of red blood cells and white blood cells, the size difference is nearly twice as large. Therefore, optical systems 400 having different magnifications may be used, and differences exist in estimating and controlling the focal length.

In addition, the components in the blood from the primary image can be identified through an artificial intelligence module previously learned using the primary image.

Specifically, the AI module learns about the components in the blood according to the primary image, and after learning is completed, inputs the primary image so that the components in the blood can be classified, and according to the components in the divided blood The focusing may be performed by differently controlling the focal length.

In addition, the control unit 600 measures the focal length (Z _{n + 1} ) corresponding to the measurement position X _{n + 1} , Y _{n + 1} on the specimen plate ₁ in advance at the measurement position X _n-1 , Y _It is calculated based on the first equation calculated from the focal length (Z _n-1 ) corresponding to _n-1 and the focal length (Z _n ) corresponding to measurement positions X _n and Y _n , and the calculated focal length (Z _n) Focusing may be performed by controlling a focal length of the optical system 400 based on ₊₁ ).

Specifically, as the sample plate 1 or the optical system 400 continues to move, focusing on other points of blood on the sample plate 1 is performed using the planned focal length to feedback the following. It is to control to estimate the ideal focal length at the position.

For example, if the focus distance at the first position and the second position is increasing, the optical system 400 may be controlled in the direction in which the focal length at the third position is increased to perform focusing.

The above is merely a description of some of the preferred embodiments that can be implemented by the present invention, so, as is well known, the scope of the present invention should not be construed as being limited to the above embodiments, and the present invention described above. It will be said that the technical idea and the technical idea together with the fundamental are all included in the scope of the present invention.

100: stage unit 200: light irradiation unit
300: image acquisition unit 400: optical system
500: horizontal moving part 600: control part

Claims (18)

A stage unit 100 on which a specimen plate 1 on which blood to be diagnosed is mounted for diagnosis of disease infection;
A light irradiation unit 200 positioned at a lower side of the stage unit 100 to irradiate diagnostic light to blood located at a diagnostic position among blood smeared on the specimen plate 1;
An image acquiring unit 300 positioned on the upper side of the light irradiating unit 200 to obtain a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiating unit 200 )Wow;
A first magnification lens unit 410 positioned between the stage unit 100 and the image acquisition unit 300 so that the image acquisition unit 300 has a first magnification to obtain a diagnosis target image having different magnifications. ) And a second magnification lens unit 420 having a second magnification greater than the first magnification;
A horizontal moving unit for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1. 500;
After performing the primary image acquisition process of acquiring the low magnification diagnosis target image through the first magnification lens unit 410 and the primary image acquisition process, obtaining a high magnification diagnosis target image through the second magnification lens unit 420. In order to perform the secondary image acquisition process, a blood diagnosis device characterized in that it comprises a control unit (600) for focusing by controlling the focal length of the optical system (400) for blood smeared on the specimen plate (1). . The method according to claim 1,
The control unit 600, the blood to be diagnosed within the depth (D1) of the first magnification lens unit 410 based on the focal length of the first magnification lens unit 410 measured in the first image acquisition process Blood diagnostic apparatus characterized in that to perform the focusing by controlling the focal length of the second magnification lens unit 420 for. The method according to claim 1 or claim 2,
The light irradiation unit 200, the blood diagnosis device, characterized in that installed respectively corresponding to the first magnification lens unit 410 and the second magnification lens unit 420 of the optical system 400. The method according to claim 1,
The control unit 600,
When performing diagnosis on the blood smeared on each specimen plate 1, the artificial intelligence module is used to learn the correlation with the focal length Z corresponding to the measurement positions X and Y on the specimen plate 1,
Before performing diagnosis on the blood smeared on the sample plate 1, the focal length Z _n corresponding to the reference positions X _n and Y _n of _n (n is a natural number of 2 or more) preset on the sample plate 1 is sampled. ,
The sampling results of the estimated focal length in the n X _n, Y _n, Z _n, and the position of each X, Type Y coordinates through the artificial intelligence module, a pre-learning on the sample plate (1) X, Y coordinates ( A blood diagnosis apparatus characterized by performing the focusing by obtaining the Z) and controlling the focal length of the optical system 400 based on the obtained Z. The method according to claim 1 or claim 2,
The control unit 600,
Acquire the primary image at the measurement position X and Y coordinates on the sample plate 1 and confirm the components in the blood at the measurement position from the obtained primary image,
A blood diagnostic apparatus characterized in that focusing is performed by controlling a focal length of the optical system 400 based on the size of the component. The method according to claim 5,
Blood diagnostic device, characterized in that the component in the blood from the primary image, using the primary image is identified through an artificial intelligence module previously learned. The method according to claim 1,
The control unit 600,
The focal length (Z _{n + 1} ) corresponding to the measurement positions X _{n + 1} and Y _{n + 1} on the specimen plate 1 is measured in advance, and the focal length corresponding to the measurement positions X _n-1 and Y _n-1 ( Z _n-1 ) and the first equation calculated from the focal length (Z _n ) corresponding to the measurement position X _n , Y _n ,
A blood diagnosis apparatus characterized in that focusing is performed by controlling a focal length of the optical system 400 based on the calculated focal length (Z _{n + 1} ). A stage unit 100 on which a specimen plate 1 on which blood to be diagnosed is mounted for diagnosis of disease infection;
A light irradiation unit 200 positioned at a lower side of the stage unit 100 to irradiate diagnostic light to blood located at a diagnostic position among blood smeared on the specimen plate 1;
An image acquiring unit 300 positioned on the upper side of the light irradiating unit 200 to obtain a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiating unit 200 )Wow;
An optical system 400 positioned between the stage unit 100 and the image acquisition unit 300 so that the image acquisition unit 300 acquires an image to be diagnosed;
A horizontal moving unit for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1. 500;
It includes a control unit 600 for controlling the image acquisition unit 300, the optical system 400 and the horizontal moving unit 500,
The control unit 600,
When performing diagnosis on the blood smeared on each specimen plate 1, the artificial intelligence module is used to learn the correlation with the focal length Z corresponding to the measurement positions X and Y on the specimen plate 1,
Before performing diagnosis on the blood smeared on the sample plate 1, the focal length Z _n corresponding to the reference positions X _n and Y _n of _n (n is a natural number of 2 or more) preset on the sample plate 1 is sampled. ,
The sampling results of the estimated focal length in the n X _n, Y _n, Z _n, and the position of each X, Type Y coordinates through the artificial intelligence module, a pre-learning on the sample plate (1) X, Y coordinates ( A blood diagnosis apparatus characterized by performing the focusing by obtaining the Z) and controlling the focal length of the optical system 400 based on the obtained Z. The method according to claim 8,
The control unit 600,
Acquire the primary image at the measurement position X and Y coordinates on the sample plate 1 and confirm the components in the blood at the measurement position from the obtained primary image,
A blood diagnostic apparatus characterized in that focusing is performed by controlling a focal length of the optical system 400 based on the size of the component. The method according to claim 9,
A blood diagnostic device characterized in that the components in the blood from the primary image are identified using an artificial intelligence module previously learned using the primary image. A stage unit 100 on which a specimen plate 1 on which blood to be diagnosed is mounted for diagnosis of disease infection;
A light irradiation unit 200 positioned at a lower side of the stage unit 100 to irradiate diagnostic light to blood located at a diagnostic position among blood smeared on the specimen plate 1;
An image acquiring unit 300 positioned on the upper side of the light irradiating unit 200 to obtain a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiating unit 200 )Wow;
An optical system 400 positioned between the stage unit 100 and the image acquisition unit 300 so that the image acquisition unit 300 acquires an image to be diagnosed;
A horizontal moving unit for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1. 500;
Includes a control unit 600 for controlling the image acquisition unit 300, the optical system 400 and the horizontal moving unit 500,
The control unit 600,
Obtain the primary image at the measurement position X and Y coordinates on the specimen plate 1, and confirm the components in the blood at the measurement location from the obtained primary image,
A blood diagnostic apparatus characterized in that focusing is performed by controlling a focal length of the optical system 400 based on the size of the component. The method according to claim 11,
The control unit 600,
When checking the components in the blood from the primary image, it is determined whether white blood cells are included, and when white blood cells are included,
After controlling the focal length of the optical system 400 based on the white blood cells to obtain the first measurement image at the measurement position X and Y coordinates on the sample plate 1, the focal length of the optical system 400 is determined based on the red blood cells. Blood diagnostic apparatus characterized in that by controlling to obtain a second measurement image at the measurement position X, Y coordinates on the sample plate (1). The method according to claim 11,
The control unit 600,
Check the components in the blood from the primary image, and obtain a measurement image for the components by controlling the focal length of the optical system 400 based on the image of the preset region based on the location of the identified components. Blood diagnostic device, characterized in that. The method according to claim 11,
Blood diagnostic device, characterized in that the components in the blood from the primary image is identified based on the color and size in the primary image. The method according to claim 11,
The control unit 600,
When checking the components in the blood from the primary image, it is determined whether a parasite is included, and if a parasite is included, the specimen plate (1) is controlled by controlling the focal length of the optical system 400 based on the size of the parasite before acquiring the first measurement image. Blood diagnostic device, characterized in that for obtaining the parasite measurement image at the X, Y coordinates of the measurement position on the image. The method according to any one of claims 11 to 15,
A blood diagnostic device characterized in that the components in the blood from the primary image are identified using an artificial intelligence module previously learned using the primary image. A stage unit 100 on which a specimen plate 1 on which blood to be diagnosed is mounted for diagnosis of disease infection;
A light irradiation unit 200 positioned at a lower side of the stage unit 100 to irradiate diagnostic light to blood located at a diagnostic position among blood smeared on the specimen plate 1;
An image acquiring unit 300 positioned on the upper side of the light irradiating unit 200 to obtain a diagnosis target image of blood for a portion of blood smeared on the specimen plate 1 by the light irradiating unit 200 )Wow;
An optical system 400 positioned between the stage unit 100 and the image acquisition unit 300 so that the image acquisition unit 300 acquires an image to be diagnosed;
A horizontal moving unit for horizontally moving the stage unit 100 on which the sample plate 1 is seated so that the image acquisition unit 300 can acquire a diagnosis target image for blood smeared on the sample plate 1. 500;
It includes a control unit 600 for controlling the image acquisition unit 300, the optical system 400 and the horizontal moving unit 500,
The control unit 600,
The focal length (Z _{n + 1} ) corresponding to the measurement positions X _{n + 1} and Y _{n + 1} on the sample plate (1) is measured in advance, and the focal length corresponding to the measurement positions X _n-1 and Y _n-1 ( Z _n-1 ) and the first equation calculated from the focal length (Z _n ) corresponding to the measurement position X _n , Y _n ,
A blood diagnosis apparatus characterized in that focusing is performed by controlling a focal length of the optical system 400 based on the calculated focal length (Z _{n + 1} ). The method according to claim 1, 8, 11, 17,
A blood diagnostic device characterized in that the diagnosis target disease of the blood diagnostic device is malaria.

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