KR20200023245A - Lung cancer diagnostic sensor using breath - Google Patents

Abstract

The present invention relates to a lung cancer sensor which detects lung cancer-caused materials included in an expiration breath at a precision of ppt units to detect lung cancer and cancers early. Specifically, the lung cancer sensor using a breath comprises: a sensor electrode unit in which an energy level of oxidation-reduction potential is set to move electrons from a cathode to an anode via electrons provided by cancer-caused materials included in a breath when the breath moves between the cathode and the anode; a detection unit to detect electron motion of the sensor electrode unit; a display unit to show information about detection of the cancer-caused materials; a power supply unit to supply operating power to each component; and a control unit connected between the sensor electrode unit, the detection unit, and the display unit. The lung cancer sensor using the breath detects cancer-caused materials in a breath entering the sensor electrode to show the cancer-caused materials. The present invention detects cancer-caused materials by using a precise detection technique of a ppt level, and can perform an accurate diagnosis of lung cancer and other cancers from the detected cancer-caused materials. Specifically, early lung cancer which could not be detected by a conventional technique can be detected by using a molecular unit detection technique of a ppt level.

Description

Lung cancer diagnostic sensor using breath}

The present invention relates to a lung cancer sensor capable of diagnosing whether lung cancer has occurred and whether cancer has occurred by detecting a lung cancer substance (a substance caused by lung cancer) contained in exhalation (呼氣, exhalation), in particular, lung cancer By designing the energy level of the redox potential so that electrons can move from the cathode to the anode through the electrons donated by the source material, it is possible to make precise diagnosis on a molecular basis.

Although cancer has been continuously conquered by the development of preventive diagnosis, medical welfare and medical technology, cancer is still one of the deadly threats to human health.

Domestic cancer incidence increased from 3.6% in 1999 to 2012 in 2012, when it began to calculate cancer incidence rates, but fell 6.1% in 2012, but has recently increased again. In 2015, the number of domestic cancer cases was about 215,000, representing 421.4 cases per 100,000 population.

However, cancer survival rate has steadily increased, and the 5-year relative survival rate has increased from about 40% in 1995 to about 70.7% in 2015. This indicates that 2 out of 3 cancer patients survive for 5 years or more. These results indicate that cancer is continuously increasing, but progression to malignancy is suppressed.

The most important thing in preventing cancer from cure or progressing to malignancy is to detect cancer early. For example, in the case of gastric cancer, the mortality rate is gradually decreasing due to the high cure rate due to early treatment following early cancer screening. Lung cancer mortality, on the other hand, is increasing from 28.7 in 2006 to 35.1 in 2016, presumably because lung cancer is difficult to detect early.

Lung cancer occurs in airy lungs, so imaging equipment such as X-rays is not easy to detect early. In addition, the lung is a part in contact with the air, so the dissolved amount in the blood or urine of the lung cancer-causing substance generated in lung cancer is very small, and early cancer detection is not easy with conventional technology. Therefore, most lung cancers are found in the advanced state, and the actual treatment golden time is missed, which leads to the inability to treat the survival rate.

In order to detect cancer early, the development of ultra-precision sensors capable of detecting very small amounts of cancer-causing substances is urgently needed, and many studies have been continuously conducted for this purpose.

1) Cantilever type precision sensor that detects mechanical distortion caused by adsorption of a substance to be detected as a current value,

2) a precision sensor of a semiconductor sensor type for detecting a change in resistance according to adsorption of a substance to be detected;

3) A precision sensor using an asymmetric field ion transport analysis method that detects by passing a substance to be detected inside a fluctuating electric field so that only molecules having a specific mass area ratio reach the detector;

4) Precision sensors using a gene sensing method that detects using a receptor of a genetically modified mouse, such as ultra-precision sensors,

5) precision sensor using antigen antibody reaction,

6) A precision sensor using a Kelvin probe method for sensing a gas is an example of such a high precision sensor.

Republic of Korea Patent Registration No. 10-1755230 "Sensor for detecting multidrug-resistant cancer cells and method for detecting multidrug-resistant cancer cells using the same", Republic of Korea Patent Application No. 10-2012-0081710 "Nitrogen prepared from conductive polymer thin film using the screen printing technique Method of manufacturing a doped graphene-based high efficiency field effect transistor cancer diagnosis apta sensor ", Republic of Korea Patent Application No. 10-2014-0022228" Patternized carbon nanotube biosensor for cancer cell biomarker detection ", Republic of Korea Patent Registration Korean Patent Application No. 10-2016-0091997 "Field Effect Colon Cancer Sensor", Republic of Korea Patent Registration No. 10-1705179 "Automatic Color Detection Type Cancer Diagnostic Kit and Method for Providing Information for Diagnosis of Cancer Using the Same" 10-1478896 "Bio-Sensor Detection of Cancer Cells Treated with Anticancer Drugs and Manufacturing Method Thereof", Korean Patent Registration No. 10-0894800 "Lung Cancer Diagnosis SAW Sensor" It is an example of a fired arm sensor.

However, in ~ ppb (. Parts per billion 1/10 -9) conventional techniques is that the detection accuracy ^{ppm (parts per million, 1/10 -6} ) level as described above, ppt (parts per trillion, 1/10 - ¹² ) There were problems such as accurate measurement reaching the level and ultra-precision measurement in molecular units.

For example, when detecting lung cancer substances, a technique for detecting trace amounts of lung cancer substances contained in respiration, blood, urine, or body fluids is required, but in the conventional case, the detection level is less than the ppt level. There were problems such as difficult detection and early cancer detection.

An object of the present invention is to solve the above conventional problems, in particular, lung cancer phosphorus material contained in the expiration to reach the ppt level by precisely by molecular unit by using the energy level of the redox potential It is to provide a new concept lung cancer sensor with precision and accuracy.

In addition, the present invention is to provide a lung cancer sensor capable of real-time detection by directly detecting the lung cancer substance through the electron transfer (current) detection through the electrons donated from the lung cancer substance.

In addition, by using a mobile induction material (anode-side mobile induction material, cathode side mobile induction material) having energy levels of various redox potentials to detect lung cancer-causing substances, the detection range is expanded, and more accurate detection is made. will be.

In other words, lung cancer-causing substances generated in the lungs are detected through exhalation, and the detection accuracy is higher than the ppt level, providing a high-precision lung cancer sensor to detect almost 100% of early lung cancer.

The present invention is a lung cancer sensor that can detect early lung cancer and cancer by detecting the lung cancer phosphorus contained in exhalation in the respiratory air with a precision of ppt or more, in particular, through the electron donating from the lung cancer phosphorus contained in exhalation By designing the energy level of the sensor electrode unit to move the electrons from the cathode to the anode, by analyzing the movement of the electrons detected in the sensor electrode portion to diagnose the initial lung cancer, it is characterized in that the accurate diagnosis.

In addition, the energy level of the sensor electrode unit may be determined by using one or more moving induction materials for relaying electron movements from the cathode to the anode (hereinafter, a material for relaying electron movements from the cathode to the anode). Design and excite energy to excite electrons from the Highest Occupied Molecular Orbital (Valence Band) to the Lowest Unoccupied Molecular Orbital (LUMO) in the conduction band Energy, thermal energy, etc.) to control the movement of electrons, so that more accurate detection is achieved.

In addition, by constituting a mobile inducer with at least one of fullerene, fullerene salt, ion-containing fullerene, dye, or complex of ion-containing fullerene and pigment, the redox potential is lowered and the quantum yield is reduced. I) to increase the detection range and improve the measurement sensitivity.

The fullerene is any one of C60, C70, C72, C78, C82, C90, C94, C96, and the ions contained in the iontofullerene are lithium, sodium, potassium, cesium, magnesium, calcium, Or strontium, and the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT , P3OT, POPT, MDMO-PPV, MEH-PPV and the like, characterized in that at least one of a polymer or a derivative thereof.

The lung cancer substance is toluene (Toluene), 2,6-Diisopropyl phenol (2,6-Diisopropylphenol) (propofol, propofol), 2-methylpyrazine (2-Methylpyrazine), cyclohexanone (Cyclohexanone), 2- It is characterized in that any one or more of butanone, acetic acid, acetone, acetonitrile.

Lung cancer sensor using the exhalation of the present invention, in particular, lung cancer phosphorus material contained in the exhalation can detect almost 100% lung cancer including the initial state by detecting the ppt level precision using the energy level of the redox potential It works.

In addition, by designing the energy level using a mobile inducing substance, it is effective to widen the detection range, increase selectivity, and increase the accuracy of lung cancer diagnosis.

In addition, the energy level of the redox potential is very low and the quantum yield is high by using ionic inclusion fullerenes and pigments to design the energy level to further extend the detection range and accuracy of cancer diagnosis.

The present invention has the effect of detecting lung cancer substances by using a precise detection technology of the ppt level or more, and accurate lung cancer diagnosis and other cancers from the detected lung cancer substances. In particular, by using the molecular detection technology of the ppt level or more, there is an effect that can detect early lung cancer that could not be detected by the existing technology.

1 is a block diagram showing a system configuration according to the present invention;
2 is a view showing the configuration of the sensor electrode of the present invention,
3 is a view showing a configuration of a sensor electrode unit according to an embodiment of the present invention;
4 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention;
5 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention;
6 is a conceptual diagram showing (a) ionic inclusion fullerene, (b) constituting a polymer in which ionic inclusion fullerene and a dye are bonded, (c) an excited state of electrons by light energy,
7 is a conceptual diagram showing the electrophoresis of fullerene-pigment polymer on the positive electrode,
8 is a view showing an energy level of electrons,
9 is a view showing an energy level design according to the present invention;
10 is a view showing another energy level design according to the present invention,
11 is a view showing another energy level design according to the present invention,
12 is a view showing another energy level design according to the present invention,
13 is a view showing another energy level design according to the present invention,
14 is a view showing another energy level design according to the present invention,
15 is a view showing another energy level design according to the present invention,
16 is a view showing another energy level design according to the present invention,
17 is a view showing another energy level design according to the present invention,
18 is a view showing another energy level design according to the present invention,
19 is a view showing another energy level design according to the present invention,
20 is a view showing another energy level design according to the present invention,
21 is a view showing another energy level design according to the present invention,
22 is a view showing yet another energy level design according to the present invention,
23 is a view showing an energy level design according to an embodiment of the present invention;
24 is a view showing another energy level design according to an embodiment of the present invention;
25 is a cross-sectional view showing the configuration of an expiration apparatus according to the present invention;
Figure 26 (a) is a view showing a method of using the exhalation trap, (b) is a cross-sectional view showing the process of collecting the exhalation through the exhalation inlet pipe and the inlet and outflow pipe, (c) is a A cross-sectional view showing the mounting method, (d) is a cross-sectional view showing the supply of the collected exhalation to the sensor electrode using the elastic restoring force, (e) is a cross-sectional view showing the supply of the collected exhalation to the sensor electrode using a fan,
27 is a circuit diagram conceptually showing the circuit configuration of a potentiostat;
28 is a diagram showing an example of a configuration of a measuring electrode;
29 is a graph illustrating interval expansion of a CV graph;
30 is a graph showing an example of quantum yield according to wavelength;

The technical idea of the present invention will be described in detail with reference to specific configurations and embodiments as follows.

In describing the configurations and embodiments of the present invention, the same or similar names and symbols are used for components having the same or similar configurations and functions, and additional or duplicated or limited meanings of the inventions may be interpreted. The description may be omitted in describing the embodiments of the present invention.

Prior to the detailed description, the concept of the invention, in spite of the singular form of the present disclosure, in the light of the circumstances in which the singular / plural is not clearly distinguished in the Korean language and the general terminology in the art. It is used in the sense that it includes plural expressions unless otherwise contradictory or clearly different from each other. In addition, 'includes', 'haves', 'comprises', 'comprises', and the like, as described or described herein, may indicate the presence or addition of one or more other features or components or combinations thereof. It should be understood that it is not excluded in advance.

According to the technical idea of the present invention "lung cancer sensor using the exhalation", as shown in Figure 1, the energy level of the redox potential to move the electrons from the cathode to the anode via the lung cancer phosphorus material contained in the exhalation The sensor electrode unit 120 is designed; An excitation energy supply unit 130 for supplying excitation energy of electrons to the sensor electrode portion; A detection unit 110 for detecting electron movement of the sensor electrode unit 120; A display unit 160 showing the detection contents of the detection unit 110; A data storage unit 140 for storing detection contents of the detection unit; Communication unit 170 for transmitting the detection information; A control unit 150 connected to the sensor electrode unit 120, the excitation energy supply unit 130, the detection unit 110, the data storage unit 140, the display unit 160, and the communication unit 170; And a power supply unit 180 for supplying operating power to each of the components, and detecting and displaying a lung cancer-causing substance in the exhalation flowed into the sensor electrode unit 120. .

The present invention, when the breath of the subject flows between the cathode and the anode of the sensor electrode unit 120, the sensor to move the electrons from the cathode to the anode via the electrons donated from the lung cancer phosphorus material contained in the breath The energy level of the redox potential of each component constituting the electrode part is designed.

That is, the energy level is designed so that the number of electrons proportional to the lung cancer phosphorus material contained in the exhalation moves from the cathode to the anode, and whether the lung cancer phosphorus substance is present by detecting whether the electrons move (current flow). Determining whether the lung cancer is caused by detecting the degree of movement of the electrons (current amount) and precisely determining the amount of the injected cancer cancer substance, and whether the lung cancer has occurred and whether the cancer has occurred from the type and amount of the cancer cancer substance is detected data The data is stored in the storage unit 140, displayed through the display unit 160, and transmitted to the external device through the communication unit 170.

Since the electron movement is proportional to the number of molecules of the incoming lung cancer substance, the lung cancer substance can be detected in a molecular unit, and the real time detection is possible by indicating the amount of the lung cancer substance in current.

In the above configuration, as shown in Figure 25, the breathing apparatus 190 for collecting the breath of the subject; characterized in that it further comprises.

The exhalation collecting device 190 is for easily collecting the exhalation of the subject to supply to the sensor electrode unit 120.

The lung cancer substance is a lung cancer metabolite that is caused by cancer, and the discovery of this lung cancer substance means that there are lung cancer cells in the body.

Lung cancer agents include toluene, 2,6-diisopropylphenol, 2-methylpyrazine, cyclohexanone, 2-butanone, acetic acid, acetone And acetonitrile. When lung cancer substance is detected, the type of lung cancer substance is determined, and the ratio of each lung cancer substance is judged to determine the progress of cancer.

The detection unit detects at least one of cyclic voltammetry (CV), chrono amperometry (CA), or chrono potentiommetry (CP), or stripping voltammetry (SV), or linear sweep voltammetry (LSV). Detecting the presence and amount of the substance.

In other words, using a potentiostat to measure the presence or amount of lung cancer substance by measuring CV, or CA, or CP, or SV, or LSV of the lung cancer substance. do.

At this time, the collected exhaled exhalation is preferably used diluted in a specific solvent.

FIG. 27 is a circuit diagram illustrating a simplified configuration of a potentiostat, and detects lung cancer phosphorus through a working electrode (W), a reference electrode (RE), and a counter electrode (CE). can do. That is, after constructing the working electrode (W) using a moving induction material (anode-side moving induction material, cathode side moving induction material), after obtaining the CV, CA, CP, SV, LSV, etc. By analyzing this, it is possible to precisely measure the presence and amount of lung cancer substance.

Since the structure and operation principle of the potentiostat used in the electrochemical field, the three-electrode method, the two-electrode method, CV, CA, CP, SV, LSV, etc. are well known, the detailed description thereof is omitted.

The detection unit is characterized by detecting the presence and amount of lung cancer-causing substances by detecting the quantum yield (IPCE: Incident Photon to Current Efficiency) according to the wavelength of the light source supplied to the excitation energy.

FIG. 30 shows the quantum yield (IPCE) according to the wavelength of the light source. As shown in the figure, the quantum yield according to the wavelength varies depending on the material. Therefore, it is possible to know the presence of a lung cancer substance by using the characteristics of the quantum yield curvature. For example, the quantum yield graph of Fig. 30A has a maximum at about 440 nm, a second peak value at 560 nm, and a third order peak value at 620 nm, and this characteristic (peak value, wavelength, slope, peak spacing, etc.). ) To determine the presence of lung cancer.

Since the quantum yield measurement is well known, its detailed description is omitted.

The excitation energy supply unit 130 is any one of an optical energy supply unit (not shown), an electromagnetic wave energy supply unit (not shown), or a thermal energy supply unit (not shown) for supplying energy equal to or greater than the band gap energy between the valence band and the conduction band. It is characterized by consisting of the above.

The excitation energy supply unit 130 is configured to supply excitation energy using light energy, electromagnetic wave energy, or thermal energy, and in some cases, excitation energy may be configured by using two or more energy sources together. For example, the light energy may be configured to supply a predetermined amount of excitation energy, and heat energy to supply the remaining excitation energy. Such a configuration is preferably used when one energy source cannot supply excitation energy of a desired size.

In the description, the term "electromagnetic wave" includes both heat and light, but is used for convenience of description.

The light irradiated by the optical energy supply unit is characterized by consisting of one or more lights having different wavelengths and brightness.

The light source irradiated by the light energy supply unit is preferably composed of one or more of LED light sources having different wavelengths, laser light sources having different wavelengths, halogen lamps, mercury lamps, or xenon lamps.

Such an optical energy supply unit is for supplying different bandgap energy by designing an amount of excitation energy by wavelength or brightness. For example, when a plurality of anode-side induction materials or cathode-side movement induction materials are used, and the bandgap energy of the used mobile induction materials is different, and each bandgap energy needs to be supplied separately, This can be achieved by adjusting the wavelength or brightness of the light to be supplied.

At this time, the band gap energy can be supplied to all the mobile induction materials by using one light separately. That is, it is possible to configure to supply excitation energy to a plurality of moving induction materials by using one light source supplying energy above the largest bandgap energy.

Since the configuration and operation of the driving device for driving the different light sources are well known, detailed description thereof will be omitted.

The electromagnetic wave supplied from the electromagnetic wave energy supply unit is characterized by consisting of one or more electromagnetic waves having different wavelengths and intensities.

The electromagnetic wave energy supply unit is for supplying different bandgap energy by designing the amount of excitation energy by wavelength or output intensity. For example, electromagnetic waves such as 1.0 GHz, 1.2 GHz, and 2 GHz may be used.

Since the configuration and operation of the electromagnetic wave generating device for supplying the different electromagnetic waves are well known, detailed description thereof will be omitted.

The heat irradiated by the heat energy supply unit is characterized by consisting of one or more heat having different temperatures and intensities.

The thermal energy supply unit is designed to supply different bandgap energy by designing an amount of excitation energy by temperature and intensity. For example, it can be comprised so that heat, such as 1,000 degreeC heat and 1,500 degreeC heat, may be supplied.

Since the configuration and operation of the heat generating device for generating heat are well known, detailed description thereof will be omitted.

The display unit 160 preferably includes a visual display unit 161 that visually displays information on the detection of lung cancer-causing substances, and an auditory display unit 162 that is acoustically displayed.

The communication unit 170, a wired communication unit 171 for transmitting information on the detection of lung cancer substance to a wired line (dedicated line, dedicated network, Internet, etc.), and wireless (wireless communication, mobile communication, Short-range wireless communication, Wi-Fi, Bluetooth, etc.) is preferably composed of a wireless communication unit 172 for transmitting.

The sensor electrode unit 120 may be configured in various forms as follows according to the lung cancer substance to be detected.

<Sensor Electrode Part 1>

Configuration 1 of the sensor electrode unit according to the technical idea of the present invention, as shown in Figure 9, the negative electrode configured to have a redox potential higher than the energy level of the valence band of the lung cancer group material contained in the expiration; And an anode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material, and when the lung cancer phosphorus material is introduced between the cathode and the anode, The technical configuration is characterized by the fact that the energy level is set to allow electron movement to the anode.

The sensor electrode configured as described above, the energy level of the cathode is designed to be higher than the lung cancer phosphorus material, the energy level of the anode is designed to be lower than the lung cancer phosphorus material, electrons from the cathode to the anode via the electrons donated from the lung cancer phosphorus material The movement of the will be made.

The relationship between the energy level c of the valence band of the positive electrode, the energy level e of the valence band of the lung cancer substance, and the energy level a of the valence band of the negative electrode is as follows.

Energy level of Sensor Electrode Part 1: c <e, e <a

In the sensor electrode unit 1, when the lung cancer phosphorus material having an energy level between the energy level of the cathode and the energy level of the anode is introduced, the electrons in the valence band of the lung cancer phosphorus material have a lower energy level than their own. The electrons move from the cathode to the holes of the valence band of the lung cancer phosphorus substance caused by the electrons moved to the anode, and the number of electrons proportional to the lung cancer phosphorus substance is maintained as long as the lung cancer phosphorus substance exists. Will be moved to.

At this time, it is possible to determine whether lung cancer substance is present by detecting the movement of electrons (whether the current flows), and precisely determine the amount of lung cancer substance introduced by detecting the degree of movement of electrons (amount of current). have.

In addition, it is determined whether the lung cancer occurs and other cancers from the type and amount of the cancer-causing agent, the composition ratio.

<Sensor Electrode Part 2>

As shown in FIG. 10, the configuration of the sensor electrode unit includes: a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the expiration unit; And an anode configured to have a redox potential lower than the energy level of the conduction band of the lung cancer phosphorus material. When the lung cancer phosphorus material is introduced between the cathode and the anode, the excitation energy is supplied from the excitation energy supply unit. The electrons in the valence band of the lung cancer phosphorus material are excited by the conduction band, the electrons excited by the conduction band are moved to the anode, and the energy level is carried out by the electrons moved from the cathode to the holes generated in the valence band of the lung cancer phosphorus material. Is set.

Energy level of sensor electrode configuration 2: c> e, e <a

The sensor electrode unit 2 configured as described above supplies excitation energy (e.g., light) larger than the band gap energy of the bandage and conduction band of the lung cancer phosphorus material to the lung cancer phosphorus material to the valence band of the lung cancer phosphorus material. The electrons in the band are excited by the conduction band, and the electrons excited in the band are transferred to the anode having an energy level lower than the energy level of the band. In addition, the electrons are moved from the cathode to the positive holes generated in the valence band of the lung cancer phosphorus material, and the current is proportional to the number of molecules of the lung cancer phosphorus substance by repeating the above process as long as the excitation energy is supplied. Is to flow.

The sensor electrode unit 2 has an electron level in the valence band of the lung cancer phosphorus material when the electrons in the valence band of the lung cancer phosphorus material cannot move to the anode because the energy level of the anode is higher than that of the lung cancer phosphorus substance. It is excited to conduct the excited electrons to the anode by using the energy level of the excited electrons.

This will be described as follows.

As is well known, as shown in Fig. 8, a band filled with electrons is called a valence band, and its highest trajectory is called a homo (HOMO). In addition, the band in which the electron is empty is called a conduction band, the lowest orbit is called LUMO, and the energy between the homo and lumo is called bandgap energy (Eg). When supplied, the electrons in the valence band can be excited by a conduction band.

As shown in FIG. 10, the sensor electrode unit 2 according to the present invention supplies energy above the bandgap energy through the excitation energy supply unit 130 to excite electrons in the valence band of the lung cancer-based material as a conduction band. By raising the level, the electrons move to the anode.

In the configuration of the sensor electrode unit, the anode or cathode is preferably made of a transparent electrode.

The transparent electrode is intended to allow the light emitted from the excitation energy supply unit 130 to pass through the lung cancer-causing material and to be irradiated. The transparent electrode is transparent conducting oxide (TCO) and F-doped [SnO₂]: fluorine-doped oxide. Tin), ITO (Indium tin oxide), AZO (Al-doped ZnO: aluminum doped zinc oxide), GZO (Ga-doped ZnO: galvanic doped zinc oxide) and the like can be used.

<Sensor Electrode Part 3>

As shown in Fig. 11, the configuration of the sensor electrode section includes: a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; And the energy level of the redox potential of the valence band is lower than that of the lung cancer group material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. An anode-side movement inducing material; when the lung cancer phosphorus material flows between the cathode and the anode, the electrons in the valence band of the anode-side movement inducing material are excited by the excitation energy supplied from the excitation energy supply unit. The electrons excited in the conduction band of the anode-side induction material move to the anode, and the electrons in the valence band of the lung cancer-based material move to the positive holes generated in the valence band of the anode-side movement inducing material. Holes in the valence band of the material set the energy level to move the electrons from the cathode. Characterized in that.

Energy level of sensor electrode configuration 3: c> e> g, e <a

As described above, the configuration of the sensor electrode unit 3 is characterized by designing an electron transfer path by further configuring an anode-side movement inducing material between the lung cancer-causing material and the anode.

In other words, by designing the anode-side movement inducing material having a lower energy level than the valence band of the lung cancer phosphorus material at the anode side, the electron transfer path is designed through the electrons donated from the lung cancer phosphorus substance.

The anode-side movement inducing material or the cathode-side movement inducing material is characterized in that it is composed of any one or more of a fullerene, a fullerene salt, ion-containing fullerenes, pigments, or polymers of ion-containing fullerenes and pigments.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96.

The ion contained in the fullerene is characterized in that any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium.

The pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV It is characterized by one or more of a high molecular polymer or derivatives thereof.

Figure 6 (a) shows the inclusion of ions in C60 fullerene, Figure 6 (b) shows the binding of the ion-containing fullerene and the dye, Figure 6 (c) is a conceptual diagram showing the excitation of electrons by light energy. to be.

Lithium-encapsulated fullerene has an advantage that the energy level of the redox potential of the valence band is very low, thereby broadening the range of lung cancer-based substances to be detected.

In addition, lithium inclusion fullerene has an advantage of improving the measurement sensitivity due to high quantum yield.

The quantum yield refers to the ratio of the number of molecules and the number of absorbed photons actually causing a chemical change in the photochemical reaction.

The anode-side movement inducing material, or cathode-side movement inducing material is characterized in that it is included in the positive electrode or the cathode by using electrophoresis (electrophoresis).

7 is a conceptual diagram showing an example in which the fullerene-pigment polymer 122c is electrophoresed on the positive electrode 121a.

The anode-side induction material or cathode-side movement induction material may be a material having energy levels of various redox potentials, such as [TiO₂], [Sn02], using a more precise and accurate energy level using such a mobile induction material Can be designed.

<Sensor Electrode Part 4>

The configuration of the sensor electrode portion 4, as shown in Figure 12, the cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the expiration; An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; And, an anode configured such that the energy level of the redox potential of the valence band is lower than that of the conduction band of the lung cancer-causing material, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. When the lung cancer phosphorus material is introduced between the cathode and the anode, first, the electrons in the valence band of the anode-side movement inducing material by the excitation energy supplied from the excitation energy supply unit. Electrons excited by the conduction band of the anode-side moving induction material move to the anode, and second, electrons in the valence band of the lung cancer-based material are excited by the excitation energy supplied from the excitation energy supply unit. The electrons excited by the conduction band of the lung cancer-causing substance are generated in the valence band of the anode-side transfer inducing substance. Moving to the positive hole, and third, the energy level is set so that the process of the electrons from the cathode to the hole formed in the valence band of the lung cancer-causing material is made.

Energy level of sensor electrode configuration 4: c> g> e, e <a

The sensor electrode structure 4 configured as described above is configured to excite the electrons in the valence band of the lung cancer phosphorus substance and the anode-side movement inducing substance as a conduction band in the design of the electron migration path according to the inflow of the lung cancer phosphorus substance. There is a characteristic.

<Sensor Electrode Part 5>

As shown in FIG. 13, the configuration of the sensor electrode portion includes: a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; An anode configured to have a redox potential lower than that of the valence band of the lung cancer phosphorus substance; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band has an energy level higher than the energy level of the valence band of the lung cancer material. It comprises a cathode-side movement inducing material; when the lung cancer phosphorus material is introduced between the cathode and the anode, first, the electrons in the lung cancer phosphorus material is moved to the anode, and second, to the excitation energy supplied from the excitation energy supply unit The electrons in the valence band of the cathode-side transfer inducing substance are excited by the conduction band, and the electrons excited in the conduction band of the cathode-side transfer inductive substance move to the holes generated in the valence band of the lung cancer-based material. Third, the cathode side The energy level is set so that electrons move from the cathode to the hole formed in the valence band of the mobile induction material. Characterized in that determined.

Energy level of sensor electrode configuration 5: c <e, e> a> i

The sensor electrode unit 5 configured as described above is characterized in that when the energy level of the lung cancer-causing material is higher than that of the cathode, smooth electron transfer can be performed by the cathode-side movement inducing material.

<Sensor Electrode Part 6>

As shown in FIG. 14, the configuration of the sensor electrode unit includes: a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; An anode configured to have a redox potential lower than the energy level of the conduction band of the lung cancer substance; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band has an energy level higher than the energy level of the valence band of the lung cancer material. When the lung cancer phosphorus material is introduced between the cathode and the anode, first, the electrons in the valence band of the lung cancer phosphorus material are excited by the excitation energy supplied from the excitation energy supply unit. The electrons excited by the conduction band of the lung cancer phosphorus material move to the anode, and the electrons in the valence band of the cathode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the Electrons excited by the conduction of the cathode-side transport inducing material are holes generated in the valence band of the lung cancer-causing material. And third, an energy level is set such that electrons move from the cathode to holes formed in the valence band of the cathode-side movement inducing material.

Energy level of sensor electrode component 6: c> e, e> a> i

The sensor electrode part 6 configured as described above is configured to excite the electrons in the valence band of the lung cancer phosphorus substance and the cathode-side movement inducing substance as a conduction band in designing an electron migration path according to the inflow of the lung cancer phosphorus substance. There is a characteristic.

<Sensor Electrode Part 7>

As shown in Fig. 15, the configuration of the sensor electrode portion includes: a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; The anode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer-causing material, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the redox potential of the anode. Mobile derivatives; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band has an energy level higher than the energy level of the valence band of the lung cancer material. A cathode-side moving inducer; when the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit. Electrons excited in the conduction band, and electrons excited in the conduction band of the anode-side transport inducing material move to the anode, and second, electrons in the valence band of the lung cancer-causing material move into holes formed in the valence band of the anode-side transport inducing material. Third, the home appliance of the cathode-side moving induction material by the excitation energy supplied from the excitation energy supply unit The electrons in the magnetic field are excited by the conduction band, and the electrons excited by the conduction of the cathode-side transport inducing material move to the hole formed in the valence band of the lung cancer-based material, and fourth, the electrons generated in the valence band of the cathode-side transport inducing material It is characterized in that the energy level is set so that the process of electrons move from the cathode to the positive hole.

Energy level of sensor electrode component 7: c> e> g, e> a> i

The configuration of the sensor electrode part 7 configured as described above is characterized by configuring the lung cancer sensor by designing an electron migration path according to the inflow of lung cancer-causing material using the anode-side movement inducing substance and the cathode side movement inducing substance.

<Sensor Electrode Part 8>

As shown in FIG. 16, the configuration of the sensor electrode portion includes: a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; The anode side movement is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer-causing substance, and the energy level of the redox potential of the conduction band has a higher energy level than that of the anode of the anode. Inducer; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band has an energy level higher than the energy level of the valence band of the lung cancer material. A cathode-side moving inducer; when the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side moving induction material are excited by the excitation energy supplied from the excitation energy supply unit. Electrons excited in the conduction band, and the electrons excited in the conduction band of the anode-side moving induction material move to the anode, and second, the electrons in the valence band of the lung cancer-based material are excited by the excitation energy supplied from the excitation energy supply unit. Electrons excited by the conduction band of the lung cancer-causing material The electrons in the valence band of the cathode-side mobile induction material are excited to the conduction band by the excitation energy supplied from the excitation energy supply unit, and the electrons excited in the conduction band of the cathode-side mobile induction material Fourth, the energy level is set so that the process of moving electrons from the cathode to the hole generated in the valence band of the lung cancer-causing substance, and the fourth hole formed in the valence band of the cathode-side moving induction material.

Energy level of sensor electrode configuration 8: c> g> e, e> a> i

The sensor electrode structure 8 configured as described above uses the anode-side inducing substance and the cathode-side inducing substance to design the electron migration path according to the inflow of lung cancer-causing material, and the anode-side inducing substance and the cathode-side inducing substance And it is characterized by configuring the lung cancer sensor by exciting the lung cancer.

In configuring the sensor electrode portions, the anode-side movement inducing material for inducing the movement of the donor electrons from the lung cancer-causing material to the anode, characterized in that composed of one or more.

In the above configurations, when a plurality of anode-side movement inducing materials are formed, as shown in FIGS. 17 to 18 and 21 to 22, the first anode-side movement induction for receiving electrons from the lung cancer-causing material is shown. The energy level of the conduction band of the material is set to be higher than the energy level of the valence band of the next anode-side inductive material, and the energy level of the conduction band of the anode-side mobile inductive material that contributes electrons to the anode is the energy level of the anode. The energy level of the anode-side mobile induction material in the intermediate stage is set higher than the energy level of the valence band of the anode-side mobile inductive material in the next stage. It is characterized by setting the level below the energy level of the conduction band of the anode-side mobile induction material in the previous stage.

This configuration enables the detection of cancer-causing substances by using a plurality of anode-side mobile inducing substances, and enables more accurate energy level design for lung cancer-causing substances.

In configuring the sensor electrode portions, the cathode-side movement inducing material for inducing the movement of electrons donated from the cathode to the lung cancer-causing material is characterized in that it is composed of one or more.

In the above configuration, when the cathode-side movement inducing material is composed of a plurality of pieces, as shown in FIGS. 19 to 22, the energy level of the conduction band of the first cathode-side movement inducing material that receives electrons from the cathode is The energy level of the conduction band of the cathode-side moving inducer which is higher than the energy level of the valence band of the cathode-side moving inducer and donates electrons to the holes generated in the valence band of the lung cancer-based material is The energy level of the cathode-side mobile induction materials in the middle stage is set higher than the energy level of the valence band, and the energy level of the conduction band is set higher than that of the valence band of the cathode-side mobile induction material in the next stage. In other words, the energy level of the valence band is set lower than that of the conduction band of the cathode-side mobile inductive material in the previous stage. It shall be.

This configuration is to enable the detection of lung cancer substances by using a plurality of cathode-side mobile inducing substances, it is possible to design a more accurate energy level for lung cancer substances.

The expiratory capturing apparatus 190, as shown in Figure 25, the expiratory pocket 193, the expiratory air is collected; The exhalation pocket (193) is provided therein, the quantitative outer shell (194) for limiting the amount of aerobic air collected in the exhalation pocket (193); An exhalation inlet tube 191 provided at one side of the exhalation pocket 193 and injecting a subject into the mouth and blowing exhalation; And an exhalation outlet tube 196 provided at the other side of the exhalation pocket 193 and supplying the collected exhaled air to the sensor electrode unit 120.

The exhalation inlet pipe 191 is further provided with an inlet opening and closing means 192 which is a one-way opening and closing means that is opened only in the direction of the internal collecting portion 195 of the exhalation pocket 193, the exhalation outlet pipe 196 is a sensor It is preferable to further include an outflow opening and closing means 197 which is a one-way opening and closing means that opens only in the inner direction of the electrode portion 120.

Hereinafter, the technical idea of the lung cancer sensor using the present invention will be described in detail with reference to Examples.

In the description, the same or similar names and symbols are used for components having the same or similar configurations and functions.

Example 1

In Example 1, the detection of 2,6-diisopropyl phenol (2,6-Diisopropylphenol), which is one of the lung cancer-causing substances that occur when lung cancer occurs, will be described as an example.

In addition, in the first embodiment, an FTO (F-doped [SnO₂]) transparent electrode is used as the anode and platinum (Pt) is used as the cathode.

In addition, in Example 1, fullerene [C60] is used as an anode side movement inducing substance, and it demonstrates as an example.

Therefore, the sensor electrode part according to the first embodiment uses FTO as the anode, electrophoreses [C60] to the FTO, and uses platinum (Pt) as the cathode. In addition, the excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material is further configured, and the excitation energy supply unit will be described as an example of supplying optical energy.

In addition, in the first embodiment, when the lung cancer-causing substance (2,6-diisoprophylphenol) is introduced into the sensor electrode, a detection unit for detecting the flow of electrons moving from the cathode to the anode, and the detection information (detection process, A display unit for displaying detection conditions, detection results, etc.), a data storage unit for storing the detection conditions, and a communication unit for exchanging information on the detection with an external device will be described as an example.

In addition, in Example 1, the detection of 2,6-diisoprophylphenol contained in the exhalation (exhalation) will be described as an example. Therefore, the sensor electrode unit will be described with an example in which a structure in which exhalation can flow between a cathode and an anode is configured. Exhalation (exhalation) containing lung cancer material is supplied to the sensor electrode unit using a pumping device.

In addition, in the present Example 1, the expiration apparatus is described by providing an inlet opening and closing means and an outlet opening / closing means provided with an exhalation pocket in the fixed quantity outer shell and a one-way valve in the exhalation inlet pipe and the exhalation outlet pipe.

The reason why the first embodiment is configured as described above is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

 Hereinafter, the configuration of the first embodiment configured as described above with reference to the accompanying drawings in detail as follows.

1) Composition of Exhalation Collector

As shown in FIG. 25, the exhalation collecting device 190 fits an exhalation pocket 193 into the inside of the quantitative jacket 194, and an exhalation inlet pipe 191 and an inflow opening / closing means on one side of the exhalation pocket 193. 192 is provided, and the air outlet pipe 196 and the outflow opening / closing means 197 are provided on the opposite side.

2) Energy level design of sensor electrode

The energy level design process of Example 1 for detecting 2,6-diisoprofil phenol is described with reference to FIG.

The energy level of the valence band 2,6-diisoprophylphenol based on the vacuum of the valence band is -5.93 eV, and the energy level of the conduction band is -0.01 eV. Therefore, the energy level of the negative electrode requires an electrode having an energy level higher than -5.93 eV, which is the energy level of the valence band of 2,6-diisoprophylphenol, which is the lung cancer group material. In Example 1, platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode. Therefore, when 2,6-diisoprophyl phenol, a lung cancer substance, is contacted with a cathode composed of platinum (Pt), electrons can move from the cathode to a hole generated in the valence band of 2,6-diisoprophyl phenol, a lung cancer substance. It has an energy level structure.

In Example 1, 2,6-diisoprophylphenol, a lung cancer-based substance detected in the present invention, has a low energy level of -5.93 eV in the valence band, and thus requires a cathode-side mobile induction material having a lower energy level. In Example 1, [C60] having an energy level of -6.72 eV in the valence band is used as the anode-side inductive material. The energy level of the valence band of [C60] used as the anode-side transport inducing substance is lower than the energy level of the valence band of the 2,6-diisoprophylphenol, which is the lung cancer group substance, at -5.93 eV. The electrons in the valence band of soprophyllphenol have an energy level structure that can move to the positive holes generated in the valence band of [C60].

Since the energy level of the conduction band of [C60], which is the anode-side inductive substance, is -3.89 eV, and the energy level of the valence band of the FTO used as the anode, is -4.85 eV, the electrons excited in the conduction band of [C60] are anodes. It has an energy level structure that can move to.

That is, when the condition is satisfied, electrons excited in the electron band of [C60] which is the anode-side transfer inducing substance move to the anode, and holes generated in the valence band of [C60] are lung cancer-causing substances 2,6- The electrons of the diisoprophyl phenol are moved, and the electrons move in the platinum (Pt), which is a cathode, as holes generated in the valence band of the 2,6-diisoprophyl phenol.

Excitation of [C60], which is the anode-side mobile induction material, requires a power of 2.83 eV or more, which has a wavelength of 438 nm. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp that meets the above conditions can be used.

Figure 23 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, once the excitation process according to the energy level when 2,6-diisoprophylphenol which is a cancer-causing substance is introduced It is designed to move electrons from cathode to anode via

3) Sensor electrode part composition

As shown in FIG. 3, the sensor electrode unit 120 according to the first embodiment is configured by mounting the anode 121 and the cathode 124 in the case 125.

The operating power is supplied to the positive electrode 121 and the negative electrode 124 through a power supply unit 180, and the detection unit 110 is connected to detect a current flowing between the positive electrode 121 and the negative electrode 124. .

The case 125 is formed of a transparent material (eg, glass, quartz, etc.) on the surface on which the anode 121, which is a transparent electrode, is mounted, and light supplied from the light source 131, which is the excitation energy supply unit 130. It is comprised so that it may irradiate to the positive electrode 121 which is this transparent electrode.

As shown in FIG. 4, the case 125 may be configured such that the light irradiated from the light source 131 is directly irradiated to the anode 121 by cutting the portion where the anode is mounted.

In the figure, reference numeral 122 denotes an anodic-side moving inducer, and 1 denotes an expiration (exhalation) containing 2,6-diisoprophylphenol which is a lung cancer-based substance.

The exhalation (exhalation) 1 passes through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120, and a detailed description thereof will be omitted.

As illustrated in FIG. 26, the air collecting device 190 is coupled to the sensor electrode unit 120 configured as described above through the coupling structure.

4) System Configuration

As shown in FIG. 1, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the first embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

Preferably, the controller 150 is configured as a microprocessor or a computer system, and the data storage 140 is configured as an internal memory of the controller 150 or an external memory controlled by the controller 150. desirable.

The data storage unit 140 stores a detection result of 2,6-diisoprophyl phenol which is a lung cancer-causing substance, and a data table showing a correlation between the amount of 2,6-diisoprophyl phenol and the amount of current.

Hereinafter, the operation of the first embodiment configured as described above will be described in detail.

First, as shown in Fig. 26, exhalation is collected. When the operator bites and blows the exhalation inlet pipe 191 into the mouth as shown in (a), the inflow opening and closing means 192 is opened by the blowing force as shown in Fig. 26 (b), and the exhalation pocket 193 This swells and exhalation is collected in the collecting space 195.

Thereafter, as shown in FIG. 26 (c), the exhalation collecting device 190 is attached to the sensor electrode unit 120. Then, the exhalation opening means 197 provided in the exhalation outlet pipe 196 by the exhalation induction pipe 127 is opened to supply the exhalation to the sensor electrode unit 120 through the exhalation induction pipe 127.

Figure 26 (d) shows that when the exhalation pocket 193 is made of a flexible material such as rubber, exhalation flows out through the exhalation guide pipe 127 by its elastic force, Figure 26 (e) When the exhalation pocket 193 is made of a material having no elasticity, such as vinyl, it shows that exhalation is supplied to the sensor electrode unit 120 through the fan 126.

The exhalation is preferably using a fan 126, as shown in Figure 26 (e). When using the fan 126, it is possible to control the amount of exhalation supplied and whether or not to supply.

When the exhaled air collected in the exhalation trap device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [C60], which is the anode-side movement inducing material 122.

Then, the electrons in the valence band of [C60], which is the anode-side movement inducing material, are excited with a conduction band, and a hole is generated in the valence band of [C60]. The energy level of the electrons excited by the conduction band of [C60] is -3.89 eV, which is higher than the energy level of -4.85 eV of the valence band of the anode FTO, and the electrons excited by the conduction band move to the anode FTO.

In this state, when 2,6-diisoprophyl phenol which is a lung cancer group substance contained in expiration flows between FTO which is a positive electrode and platinum (Pt) which is a negative electrode, it is in the valence band of the 2, 6- diisoprophyl phenol. The electrons (energy level: -5.93 eV) move to the hole (energy level: -6.72 eV) generated in the valence band of [C60] which is the anode-side transfer inducing substance, and the valence band of the 2,6-diisoprophylphenol. Holes will be generated in.

Then, the electrons (energy level: -5.93eV) in the valence band of platinum (Pt) as the positive hole (energy level: -5.93 eV) generated in the valence band of the lung cancer-causing substance 2,6-diisoprophylphenol Will move.

Thereafter, as long as the excitation energy is supplied from the excitation energy supply unit 130, the above process is repeated, and the number of electrons proportional to the number of molecules of 2,6-diisoprophylphenol, the lung cancer-causing substance, is changed from the cathode to the anode. Will continue to move.

The detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.

The controller 150 detects whether a current flows through the detector 110 to determine whether 2,6-diisoprophylphenol, a lung cancer-causing substance, is present, and determines whether lung cancer-causing substance is present from the amount of current. The amount of 2,6-diisoprophylphenol is determined. That is, the amount of 2,6-diisoprophylphenol introduced is calculated by comparing the detected current amount with a data table indicating a relationship between the amount of lung cancer-causing substance and the current amount stored in the data storage 140.

Thereafter, the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect lung cancer.

At this time, by detecting the current flowing through the electrons donated from the lung cancer substance, it is possible to perform accurate and accurate detection proportional to the number of molecules of the lung cancer substance.

That is, the presence or absence of lung cancer phosphorus substance contained in the exhalation detects the presence or absence of cancer cells, and determine the extent of cancer by the amount of lung cancer phosphorus substance. The type of cancer is determined by the composition ratio of two or more lung cancer-causing substances detected in the same sample.

The cancer progression is determined by referring to the data table indicating the amount of cancer and the progression of cancer, and the type of cancer is determined by referring to the data table of the composition ratio of cancer and the type of cancer.

The precision of the lung cancer sensor is described as follows.

The number of molecules in the expiration of about 500cc is about 1.19 × 10 ²² .

The number of molecules contained in 1 ppt of aerobic gas of 500 cc is

1.19 × 10 ²² × 10 ^-12 = 1.19 × 10 ¹⁰ .

If this is expressed as the amount of charge,

(1.19 × 10 ¹⁰ ) × (1.62 × 10 ^{) -19} C) = about 1.19 × 10 ^-9 C = 1.9 nA.

That is, even if 1 ppt of lung cancer-causing substance is included in the expiration of 500cc it can be detected.

If 1 ppt of air contains 1% of lung cancer substance in 500cc of exhaled air, the charge amount is about 19pA.

Since the configuration of the detection unit 110 for detecting the charge amount in the nano-ampere (nA) or pico-ampere (pA) unit is well known, its detailed description is omitted.

On the other hand, in the present invention [C60] fullerene and lithium ion-encapsulated fullerene constituting a mobile induction material (anode-side mobile induction material, negative electrode-side mobile induction material) is about 1nm in size including an electron cloud, the lithium ion containing fullerene and The supramolecular molecule consists of pigments of about 2 nm in size.

Therefore, if the 500cc unit is said to have 1ppt of lung cancer phosphorus substance, and the mobile induction substance is composed of ultra-molecules (about 2nm) composed of lithium ion containing fullerene and pigment, the size of the plate to react the lung cancer phosphorus substance at the same time is A size of about (0.22 mm ㅧ 0.22 mm) is sufficient. If there is 1% of lung cancer-causing substances in the exhalation amount of 1 ppt out of 500cc, the positive electrode (or the negative electrode) may be made of a smaller sized electrode plate.

That is, a lung cancer sensor having a precision of ppt level or more can be configured by allowing electrons in proportion to the number of molecules of the lung cancer substance to move, and directly detecting the number of moved electrons.

Example 2

In Example 2, the detection of toluene, which is one of lung cancer-causing substances, which occurs when lung cancer occurs, will be described as an example.

In Example 2, as in Example 1, FTO is used as the positive electrode and platinum (Pt) is used as the negative electrode.

In addition, in Example 2, titanium dioxide (TiO₂) and anolyte 1 lithium-polyphorus fullerene hexafluorophosphate salt ([Li ⁺ @ C60] [PF6 ⁻ ]) were used as the anode-side secondary migration inducing substance. This will be described as an example.

Therefore, the sensor electrode part according to the second embodiment uses FTO as an anode, electrophoreses [TiO₂] and [Li ⁺ @ C60] [PF6 ⁻ ] to the FTO, and uses platinum (Pt) as the cathode. . In addition, the [TiO₂] and ^{[Li + @ C60] [PF6} -] will be described by configuring further comprises an excitation energy supply for supplying the excitation energy and to supply the light energy where the energy supply is an example.

In the second embodiment, as in the first embodiment, a detection unit, a display unit, a data storage unit, and a communication unit are described as an example, and the detection of toluene contained in the exhalation (exhalation) will be described as an example. .

The reason why the present embodiment 2 is configured as described above is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

 Hereinafter, the configuration of the second embodiment as described above with reference to the accompanying drawings in detail as follows.

1) Composition of Exhalation Collector

As in Example 1, the exhalation pocket 193 is inserted into the inside of the quantitative jacket 194, and an exhalation inlet pipe 191 and an inflow opening / closing means 192 are provided on one side of the exhalation pocket 193, and on the opposite side. It is configured to include an exhalation outlet pipe 196 and the outlet opening and closing means 197.

2) Energy level design of sensor electrode

An energy level design process of the second embodiment for detecting toluene will be described with reference to FIG. 24 as follows.

The energy level based on the vacuum of the valence band of toluene, a cancer-causing substance, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, the energy level of the cathode needs an electrode having an energy level higher than -6.55 eV, which is the energy level of the valence band of toluene, which is a lung cancer base material. In the second embodiment, platinum (Pt) whose energy level is -5.93 eV and the conduction band is -5.12 eV is used as the cathode. Therefore, when toluene, a lung cancer base material, comes into contact with the cathode made of platinum (Pt), it has an energy level structure that allows electrons to move from the cathode as holes generated in the valence band of toluene, a lung cancer base material, due to the difference in energy levels.

Toluene, a lung cancer-based substance detected in Example 2, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side inducing substance having a lower energy level is required. In Example 2, [Li + @ C60] [PF6-] having the valence band energy level of −7.70 eV is used as the anode-side first moving inducing substance. The energy level of the valence band of [Li + @ C60] [PF6-], which is used as the anode-side first mobile inducer, is lower than the energy level of the valence band of toluene, the lung cancer-causing substance, of -6.55 eV. The electrons have an energy level structure that can move to the positive holes in the valence band of [Li + @ C60] [PF6-].

Since the energy level of the conduction band of [Li + @ C60] [PF6-], which is the anode-side first moving induction material, is -4.90 eV, and the energy level of the valence band of FTO used as the anode is -4.85 eV, the [Li + @ C60 ] The electrons in the conduction band of [PF6-] cannot move directly to the anode. Therefore, a positive electrode-side second moving material is required.

The energy level of the conduction band of [Li + @ C60] [PF6-], the anode-side first induction material, is -4.90 eV, and the energy level of the valence band of the anode FTO is -4.85 eV. What is needed is a material consisting of a valence band with an energy level lower than eV and a conduction band with an energy level higher than -4.85 eV.

Titanium dioxide (TiO₂) has -6.21eV energy level in valence band and -3.21eV energy level in conduction band. do. Then, the electron excited in the conduction band of [TiO₂] has an energy level structure that can move to the anode.

That is, when the conditions are satisfied, the electrons excited in the electron band of [TiO₂], which is the anode-side second mobile induction material, move to the anode, and the positive holes in the valence band of [TiO₂] are [ Electrons excited in the conduction band of Li + @ C60] [PF6-] move, and electrons of toluene, a lung cancer-causing substance, move to holes generated in the valence band of [Li + @ C60] [PF6-]. The positive holes in the magnetic field cause the electrons to move in the platinum (Pt) cathode.

[Li + @ C60] [PF6-], which is the anode-side first mobile induction material, requires a power of 2.8 eV or more with a light source having a wavelength of 457 nm, and a wavelength of 413 nm for the [TiO₂], which is the second-side mobile induction material. Power of 3.0 eV or more is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions.

Figure 24 shows the energy level and the material designed through the process as described above, as shown in the figure, when toluene, a lung cancer-causing substance, is introduced into the electron from the cathode to the anode through two excitation processes according to the energy level It is designed to move.

3) Sensor electrode part composition

As shown in FIG. 5, the cathode 121 and the cathode 124 are mounted inside the case 125, and the operating power is supplied to the anode 121 and the cathode 124 through the power supply unit 180. In addition, the detection unit 110 is connected to detect the current flowing between the anode 121 and the cathode 124 to form the sensor electrode unit 120 according to the second embodiment.

The case 125 has a surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material, and the light supplied from the light source 131, which is the excitation energy supply unit 130, is the anode 121, which is a transparent electrode. Configure it to be investigated.

In the figure, reference numeral 122a denotes an anode-side first moving inducer, and 122b denotes an anode-side second moving inducer, and (1) represents an exhalation (exhalation) containing toluene, which is a lung cancer-causing substance.

The exhalation (exhalation) 1 is configured to pass through the inside of the sensor electrode 120 by a pump (not shown) located in the rear of the sensor electrode 120.

4) System Configuration

As shown in FIG. 1, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect the second embodiment. Configure the system. The power supply unit 180 supplies operating power to each component.

The data storage unit 140 stores a result of detection of toluene and a data table indicating a correlation between the amount of toluene and the amount of current.

Hereinafter, the operation of the second embodiment configured as described above will be described in detail.

When the exhaled air collected in the exhalation trap device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, the light source 131 of the excitation energy supply unit 130 is turned on (ON), The light energy irradiated from the light source 131 supplies excitation energy to [Li + @ C60] [PF6-], which is the anode-side first movement inducing material 122a, and [TiO₂], which is the anode-side second movement inducing material 122b. do.

Then, the electrons in the valence band of [TiO₂], which is the anode-side second moving induction material, are excited with a conduction band, and holes are generated in the valence band of [TiO₂]. The energy level of electrons excited by the conduction band of [TiO₂] is -3.21 eV, which is higher than the energy level of -4.85 eV, which is the valence band of the FTO, which is the anode, and the electrons excited by the conduction band move to the FTO, which is the anode.

By the light energy irradiated from the light source 131, the electrons in the valence band of the anode-side first moving inducer [Li + @ C60] [PF6-] are excited to the conduction band, and the [Li + @ C60] [PF6-] A hole is generated in the valence band of. The energy level of electrons excited by the conduction band of [Li + @ C60] [PF6-] is -4.90 eV, which is higher than the energy level of -6.21 eV, which is the valence band of [TiO₂], which is the anode-side second moving inducer. The excited electrons move to the hole formed in the valence band of [TiO₂].

In this state, when toluene, a lung cancer-causing substance, is introduced between the anode FTO and the cathode platinum (Pt), electrons (energy level: -6.55 eV) in the valence band of the toluene are the anode-side first inducing substance. The hole moves to the valence band of [Li + @ C60] [PF6-] (energy level: -7.70 eV), and the hole is generated in the valence band of toluene.

Then, electrons (energy level: -5.93eV) in the valence band of platinum (Pt), which is a cathode, move to the hole (energy level: -6.55eV) generated in the valence band of toluene, a lung cancer-based substance.

Thereafter, as long as the excitation energy is supplied from the excitation energy supply unit 130, the above process is repeated, and the number of electrons proportional to the toluene, the lung cancer-causing substance, is continuously moved from the cathode to the anode.

The detector 110 detects a current (movement of electrons) flowing between the cathode and the anode.

The controller 150 detects whether toluene, a lung cancer-causing substance, exists by detecting whether current flows through the detection unit 110, and determines the amount of toluene, a lung cancer-causing substance, from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected current amount with a data table indicating a relationship between the amount of lung cancer-causing substance and the current amount stored in the data storage 140.

Thereafter, the controller 150 stores the information on the detection (detection process, detection condition, detection result, etc.) in the data storage unit 140, is displayed through the display unit 160, and through the communication unit 170. By exchanging with an external device, this process is repeated to continuously detect lung cancer.

At this time, by detecting the current flowing through the electrons donated from the lung cancer substance, it is possible to perform accurate and accurate detection proportional to the number of molecules of the lung cancer substance.

That is, the presence of cancer cells is detected by the presence or absence of toluene, which is a lung cancer substance, and the extent of cancer is determined by the amount of lung cancer substance. Two or more types of cancers detected in the same sample are determined by the composition ratio of lung cancer-causing substances (e.g., composition ratios of toluene and 2,6-diisoprophylphenol, or toluene, 2,6-diisoprophylphenol, 2 Composition of methyl pyrazine, cyclohexanone, etc.)

The cancer progression is determined by referring to the data table indicating the amount of cancer and the progression of cancer, and the type of cancer is determined by referring to the data table of the composition ratio of cancer and the type of cancer.

However, in the above embodiments, it has been described with the example of detecting lung cancer phosphorus material using two anode-side mobile induction material, it will be clear that the present invention is not limited to this. That is, the arm sensor of the present invention is constructed without a moving induction material, or the arm sensor of the present invention is constructed using a plurality of anode side moving induction materials or a plurality of cathode side moving inducing materials, or as many anode sides as necessary. It is to be understood that the cancer sensor according to the present invention can be constructed by using both the mobile induction material and the required number of cathode side mobile induction materials. FIG. 2 is a diagram showing an example of the configuration of a sensor electrode part using both the positive electrode side movement inducing material 122 and the negative electrode side movement inducing material 123.

In addition, in the above-described embodiments, the light source is supplied with an excitation energy supply unit, and the light source is limited to one, which has been described as an example. However, the technical spirit of the present invention is not limited thereto. That is, the excitation energy supply unit may be configured using several different light sources, and it may be configured to supply excitation energy using different energy sources.

In addition, in the above embodiments, the detection of one lung cancer substance by one example was described as an example, but the technical spirit of the present invention is not limited to this. In other words, it can be configured to detect a number of lung cancer-causing substances. For example, it can be configured to detect two or more lung cancer-causing substances at the same time by using a plurality of anode-side inducing substances or a plurality of cathode-side inducing substances and a plurality of excitation energy supply units.

In addition, in the present embodiments, the technical idea of the present invention has been described by using toluene and 2,6-diisoprophylphenol as an example of lung cancer-based substance, but the technical idea of the present invention is not limited thereto. That is, it can be configured to detect toluene, 2,6-diisoprophylphenol, 2-methylpyrazine, cyclohexanone and other lung cancers.

In addition, in the above embodiments, the exhalation capturing apparatus constitutes an exhalation pocket 193 inside the quantitative jacket 194, and has opening and closing means having one-way direction in the exhalation inlet tube 191 and the exhalation outlet tube 196. Although it is configured using a one-way valve to the technical spirit of the present invention is not limited to this. That is, it can be configured without a quantitative jacket, it is also noted that the opening and closing means can also be configured to be opened and closed by an electronic signal.

In addition, in the above embodiments, the air trapping device has been configured separately from the sensor electrode unit, but the technical spirit of the present invention is not limited thereto. That is, the exhalation collecting device and the sensor electrode unit may be integrally formed.

In addition, the above embodiments have been described with an example of detecting the amount of electrons moved by the lung cancer-causing substance, but the technical spirit of the present invention is not limited thereto. In other words, potentiostat is used to measure CV, or measure CA, measure CP, measure SV, or measure LSV, etc. Can be. For example, as shown in FIG. 28, [TiO₂] and [Li + @ C60] [PF6-] are moved to the FTO transparent electrode to form the working electrode W, and the counter electrode is formed of the platinum electrode Pt. (CE), a reference electrode (RE) made of silver chloride electrode (AgCl), mounted on a quartz glass test tube, diluted with aerosol in a specific solvent, and then subjected to CV measurement to determine the presence and amount of lung cancer substance. Can be measured.

FIG. 29 is an enlarged graph of a portion of the CV curve, showing the response according to the energy level design of the lung cancer-causing substance ((a) curve) and the substance ((b) curve). In the curve (a), when "a" is periodically switched between irradiation and blocking of light (excitation energy), excitation occurs at the anode-side inductive material due to the excitation energy of the light, which increases the current (light irradiation). "B" shows when the light is not irradiated (the "b" section shows the state where the light source was turned off for convenience of explanation). At this time, the difference between the current value and the characteristics of the graph can be analyzed to determine the presence and amount of the cancer-causing substance. (B) The curve shows that there is no change due to excitation energy (light irradiation) because it is not a lung cancer substance.

Further, as shown in FIG. 30, it is clear that the memorized substance can be specified by using quantum yield (IPCE) according to the wavelength of the light source supplied with excitation energy as a feature element.

1: Lung Cancer
110: detector 120: sensor electrode
121: anode 122: anode-side transfer induction material
122a: anode-side first moving inducer 122b: anode-side second moving inducer
123: cathode-side movement inducing material 124: cathode-side movement inducing material
125: case 125a: opening
126: fan 127: aerobic induction pipe
130: excitation energy supply unit 131: light source
140: data storage unit 150: control unit
160: display unit 161: time display unit
162: hearing display unit 170: communication unit
171: wired communication unit 172: wireless communication unit
180: power supply unit 190: air collection device
191: aerobic inlet pipe 192: inlet opening and closing means
193: expiratory pocket 194: fixed outer jacket
195 Collection Space 196 Exhalation Pipe
197: opening and closing means W: working electrode
RE: reference electrode CE: counter electrode

Claims (37)

A sensor electrode part in which an energy level of a redox potential is set to move electrons from the cathode to the anode via the lung cancer phosphorus material included in the expiratory phase;
A detector for detecting electron movement of the sensor electrode unit;
A display unit for displaying information on detecting the lung cancer substance;
A control unit connected between the sensor electrode unit, the detection unit, and the display unit; And,
And a power supply unit supplying operation power to each of the components.
Lung cancer sensor using an exhalation, characterized in that by detecting the lung cancer substance in the exhalation flows into the sensor electrode. A sensor electrode part in which an energy level of a redox potential is set to move electrons from the cathode to the anode via the lung cancer phosphorus material included in the expiratory phase;
An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;
A detector for detecting electron movement of the sensor electrode unit;
A display unit for displaying information on detecting the lung cancer substance;
A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, and the display unit; And,
And a power supply unit supplying operation power to each of the components.
Lung cancer sensor using an exhalation, characterized in that by detecting the lung cancer substance in the exhalation flows into the sensor electrode. A sensor electrode part in which an energy level of a redox potential is set to move electrons from the cathode to the anode via the lung cancer phosphorus material included in the expiratory phase;
An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;
A detector for detecting electron movement of the sensor electrode unit;
A display unit for displaying information on detecting the lung cancer substance;
A data storage unit for storing information on detecting the lung cancer substance;
A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, and the data storage unit; And,
And a power supply unit supplying operation power to each of the components.
Lung cancer sensor using an exhalation, characterized in that by detecting the lung cancer substance in the exhalation flows into the sensor electrode. A sensor electrode part in which an energy level of a redox potential is set to move electrons from the cathode to the anode via the lung cancer phosphorus material included in the expiratory phase;
An excitation energy supply unit supplying excitation energy of electrons to the sensor electrode unit;
A detector for detecting electron movement of the sensor electrode unit;
A display unit for displaying information on detecting the lung cancer substance;
A data storage unit for storing information on detecting the lung cancer substance;
A communication unit for exchanging information on detecting the lung cancer substance substance with an external device;
A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, the display unit, the data storage unit, and the communication unit; And,
And a power supply unit supplying operation power to each of the components.
Lung cancer sensor using an exhalation, characterized in that by detecting the lung cancer substance in the exhalation flows into the sensor electrode. The method according to any one of claims 1 to 4, wherein the lung cancer substance is toluene (Toluene), 2,6-diisopropyl phenol (2,6-Diisopropylphenol), 2-methylpyrazine (2-Methylpyrazine), Cyclohexanone (Cyclohexanone), 2-butanone, acetic acid, acetone, acetonitrile lung cancer sensor using aerobic, characterized in that any one or more. The lung cancer according to any one of claims 1 to 4, wherein when the lung cancer phosphorus is detected and displayed in exhalation, the amount of lung cancer phosphorus is detected and the extent of cancer progression is determined. sensor. The method according to any one of claims 1 to 4, wherein when the lung cancer phosphorus substance is detected and displayed in exhalation, the ratio of two or more lung cancer phosphorus substances is calculated to determine the type of cancer. Lung cancer sensor. The method according to any one of claims 1 to 4, wherein the sensor electrode unit,
By designing the energy level of the redox potential so that electrons move from cathode to anode through the electrons donated from lung cancer material, a number of mechanisms for the movement of electrons are composed, so that a number of lung cancer material can be detected. Lung cancer sensor using exhalation, characterized in that configured to. The lung cancer sensor according to any one of claims 1 to 4, wherein a cathode or an anode of the sensor electrode part is formed of a transparent electrode. The lung cancer sensor of claim 6, wherein the transparent electrode is made of at least one of FTO, ITO, AZO, GZO, and TCO. The method according to any one of claims 1 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; And,
It comprises; an anode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material,
When lung cancer phosphorus material is introduced between the cathode and the anode, the lung cancer sensor using the exhalation, characterized in that the energy level is set so that the electron transfer from the cathode to the anode via the lung cancer phosphorus material. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase; And,
It comprises; a positive electrode configured to have a redox potential lower than the energy level of the conduction band of the lung cancer material
When the lung cancer phosphorus material is introduced between the cathode and the anode, the electrons in the valence band of the lung cancer phosphorus material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction band are moved to the anode. And, lung cancer sensor using the exhalation, characterized in that the energy level is set so that the process of moving the electrons from the cathode to the hole formed in the valence band of the lung cancer-causing material. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; And,
The anode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer-causing substance, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. Transfer inducing substance; including,
When lung cancer phosphorus material is introduced between the cathode and the anode, the electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the conduction band of the anode-side induction material is excited. The electrons excited to move to the anode, and the electrons in the valence band of the lung cancer-causing material move to the holes formed in the valence band of the anode-side moving induction material, and the electrons from the cathode to the holes generated in the valence band of the lung cancer-causing material Lung cancer sensor using the exhalation, characterized in that the energy level is set so that the process of moving. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance; And,
The anode side movement is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer-causing substance, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the redox potential of the anode. Inducer; consisting of,
When the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction material is excited. The electrons excited by the conduction band are moved to the anode, and the electrons in the valence band of the lung cancer phosphorus material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction cone of the lung cancer phosphorus material are excited. The electron is moved to the hole formed in the valence band of the anode-side moving induction material, and third, the energy level is set so that the process of electrons moving from the cathode to the hole formed in the valence band of the lung cancer-based material is performed. Lung cancer sensor. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential lower than that of the valence band of the lung cancer phosphorus substance; And,
The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the valence band of the lung cancer group material. Transfer inducing substance; including,
When the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the lung cancer phosphorus substance move to the anode, and second, the excitation energy supplied from the excitation energy supply unit is applied to the valence band of the cathode-side mobile induction substance. Electrons excited by the conduction band, and electrons excited by the conduction band of the cathode-side transport inducing material move to the hole formed in the valence band of the lung cancer-based material, and third, the cathode is a hole generated in the valence band of the cathode-side transport inducing material. The lung cancer sensor using the exhalation, characterized in that the energy level is set so that the process of electrons in the movement. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential lower than the energy level of the conduction band of the lung cancer substance; And,
The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the valence band of the lung cancer group material. Transfer inducing substance; including,
When the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the lung cancer phosphorus material are excited by the conduction band by excitation energy supplied from the excitation energy supply unit, and excited by the conduction band of the lung cancer phosphorus material. Electrons move to the anode, and second, electrons in the valence band of the cathode-side mobile induction material are excited as conduction bands by excitation energy supplied from the excitation energy supply unit, and electrons excited in the conduction band of the cathode-side mobile induction material The energy level is set so that the electrons move from the cathode to the holes formed in the valence band of the lung cancer-based material, and third, the holes formed in the valence band of the cathode-side moving induction material. Lung cancer sensor. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance;
The anode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer-causing substance, and the energy level of the redox potential of the conduction band has a higher energy level than that of the redox potential of the anode. Mobile derivatives; And,
The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the valence band of the lung cancer group material. Transfer inducing substance; including,
When the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. The electrons excited by the conduction of the material move to the anode, and second, the electrons in the valence band of the lung cancer-causing material move to the holes generated in the valence band of the anode-side moving induction material, and third, supplied from the excitation energy supply unit. The excitation energy causes electrons in the valence band of the cathode-side mobile induction material to be excited as a conduction band, and electrons excited in the conduction band of the cathode-side mobile induction material move to the positive hole generated in the valence band of the lung cancer-based material. Energizes the electrons to move from the cathode to the holes generated in the valence band of the cathode-side movement inducing material Lung cancer sensor using exhalation, characterized in that the level is set. The method according to any one of claims 2 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus substance contained in the expiratory phase;
An anode configured to have a redox potential higher than that of the valence band of the lung cancer phosphorus substance;
The anode side movement is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer-causing substance, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the redox potential of the anode. Inducer; And,
The cathode side is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band has a higher energy level than the energy level of the valence band of the lung cancer group material. Transfer inducing substance; including,
When the lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side induction material are excited by the excitation energy supplied from the excitation energy supply unit, and the anode-side induction is induced. The electrons excited by the conduction of the material move to the anode, and second, the electrons in the valence band of the lung cancer phosphorus material are excited by the excitation energy supplied from the excitation energy supply unit, and the excitation zone of the lung cancer phosphorus material is excited. Electrons in the valence band of the cathode-side movement inducing material are excited by the excitation energy supplied from the excitation energy supply unit, and the electrons in the valence band of the anode-side movement inducing material are excited as conduction bands. Electrons excited by the conduction of the cathode-side transfer inducing material are holes generated in the valence band of the lung cancer-causing material. Fourth, lung cancer sensor using the exhalation, characterized in that the energy level is set so that the process of moving the electrons from the cathode to the hole formed in the valence band of the cathode-side movement inducing material. The method according to any one of claims 2 to 4, wherein the energy level of the redox potential is set so that the electrons move from the cathode to the anode through the electrons donated by the lung cancer-causing material in the sensor electrode unit. In the case of constituting a plurality of anode-side movement inducing substances which induce the movement of donor electrons from the lung cancer-causing substance to the anode,
The energy level of the conduction band of the first anode-side mobile induction material receiving electrons from the lung cancer-causing material is set higher than the energy level of the valence band of the next anode-side mobile induction material,
The energy level of the conduction band of the last anode-side inductive material that donates electrons to the anode is set higher than that of the anode.
The energy level of the anode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than that of the valence band of the anode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. Exhaled lung cancer sensor characterized in that the lower than the energy level of the conduction band of the anode-side mobile induction material. The method according to any one of claims 2 to 4, wherein the energy level of the redox potential is set so that the electrons move from the cathode to the anode through the electrons donated by the lung cancer-causing material in the sensor electrode unit. In the case of constituting a plurality of cathode-side movement inducing substances that induce the transfer of electrons donated from the cathode to the lung cancer phosphorus substance
The energy level of the conduction band of the first cathode-side mobile induction material receiving electrons from the cathode is set higher than the energy level of the valence band of the next cathode-side mobile induction material,
The energy level of the conduction band of the last cathode-side mobile induction material that contributes electrons to the hole formed in the valence band of the lung cancer substance is set higher than the energy level of the valence band of the lung cancer substance.
The energy level of the cathode-side mobile induction material in the middle stage is set to the energy level of the conduction band higher than the energy level of the valence band of the cathode-side mobile induction material in the next stage, and the energy level of the valence band is set to the previous stage. The lung cancer sensor using the exhalation, characterized in that the lower than the energy level of the conduction band of the cathode-side moving induction material. The method according to any one of claims 2 to 4, wherein the energy level of the redox potential is set so that the electrons move from the cathode to the anode through the electrons donated by the lung cancer-causing material in the sensor electrode unit. The energy level can be set using an anode-side transport inducing material that induces the movement of donor electrons from the lung cancer phosphorus material to the anode or a cathode-side transport inducing material that induces the movement of the donated electrons to the lung cancer phosphorus material. In this case, the anode-side movement inducing material, or the cathode-side movement inducing material,
A lung cancer sensor using exhalation, characterized in that it is composed of any one or more of fullerenes, fullerene salts, ion-containing fullerenes, pigments, or complexes of ion-containing fullerenes and pigments. The lung cancer sensor according to claim 21, wherein the fullerene is any one of C60, C70, C72, C78, C82, C90, C94, and C96. The lung cancer sensor according to claim 21, wherein the ions contained in the iontophorus fullerene are any one of lithium, sodium, potassium, cesium, magnesium, calcium, and strontium. The method of claim 21, wherein the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), poly p-phenylene, poly p-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, Lung cancer sensor using an exhalation, characterized in that at least one of a polymer or derivative thereof, such as MDMO-PPV, MEH-PPV. The method according to any one of claims 2 to 4, wherein the energy level of the redox potential is set so that the electrons move from the cathode to the anode through the electrons donated by the lung cancer-causing material in the sensor electrode unit. The energy level can be set using an anode-side transport inducing material that induces the movement of donor electrons from the lung cancer phosphorus material to the anode or a cathode-side transport inducing material that induces the movement of the donated electrons to the lung cancer phosphorus material. In this case, the anode-side movement inducing material, or the cathode-side movement inducing material,
Lung cancer sensor using exhalation, characterized in that the electrophoresis is included in the anode or cathode. The excitation energy supply unit according to any one of claims 2 to 4, wherein the excitation energy supply unit is an optical energy supply unit for supplying light energy equal to or greater than the bandgap energy between the valence band and the conduction band, or an electromagnetic wave energy supply unit for supplying electromagnetic energy. Lung cancer sensor using exhalation, characterized in that composed of any one or more of the thermal energy supply unit for supplying thermal energy. 27. The lung cancer sensor according to claim 26, wherein the optical energy supply unit supplies one or more optical energy having different wavelengths and brightnesses. 27. The light source of claim 26, wherein the light source of the light energy supply unit comprises at least one of an LED light source having a different wavelength, a laser light source having a different wavelength, a halogen lamp, a mercury lamp, or a xenon lamp. Lung cancer sensor using exhalation. 27. The lung cancer sensor according to claim 26, wherein the electromagnetic energy supply unit supplies one or more electromagnetic energy having different wavelengths and intensities. 27. The lung cancer sensor according to claim 26, wherein the thermal energy supply unit supplies one or more thermal energy having different temperatures. The lung cancer sensor according to any one of claims 1 to 4, further comprising an exhalation apparatus for collecting exhalation of the subject. The method of claim 31, wherein the exhalation apparatus,
An exhalation pocket in which exhalation is collected;
An exhalation inlet pipe which is provided at one side of the exhalation pocket and injects an exhaler into the mouth by a subject; And,
And an exhalation pipe provided on the other side of the exhalation pocket for supplying the exhaled air collected by the sensor electrode part. The method of claim 31, wherein the exhalation apparatus,
An exhalation pocket in which exhalation is collected;
The exhalation pocket is provided therein, and a quantitative jacket for limiting the amount of aerobic air collected in the exhalation pocket;
An exhalation inlet pipe provided at one side of the exhalation pocket and injecting a subject into the mouth; And,
And an exhalation pipe provided on the other side of the exhalation pocket and supplying the collected exhalation unit to the sensor electrode unit. 33. The method of claim 32, wherein the exhalation apparatus,
The lung cancer sensor using an exhalation, characterized in that it further comprises; inlet opening and closing means which is a one-way opening and closing means that is opened only in the direction of the internal collecting portion of the exhalation pocket in the exhalation inlet pipe. 33. The method of claim 32, wherein the exhalation apparatus,
The lung cancer sensor using an exhalation, characterized in that it further comprises; the exhalation opening and closing means which is a one-way opening and closing means to be opened only in the inner direction of the sensor electrode portion to the exhalation supply pipe. The method according to any one of claims 1 to 4, wherein the detection unit, Cyclic Voltammetry (CV), Chrono Amperometry (CA), Chrono Potentiommetry (CP), or Stripping Voltammetry (SV), or Lung cancer sensor using an exhalation, characterized in that the detection of any one or more of LSV (Linear Sweep Voltammetry) to detect the presence and amount of the lung cancer substance. According to any one of claims 1 to 4, wherein the detection unit detects the presence and amount of lung cancer-based substance by detecting the quantum yield according to the wavelength of the light source supplied to the excitation energy using aerobic Lung cancer sensor.

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