KR102094322B1 - Lung cancer diagnostic sensor using breath - Google Patents

Abstract

The present invention is a lung cancer sensor capable of detecting the initial lung cancer and cancer by detecting the lung cancer phosphorus substance contained in the exhalation with a precision of ppt unit among breath exhalation, particularly, when the exhalation flows between the cathode and the anode, the exhalation A sensor electrode unit in which the energy level of the redox potential is set so that electrons are transferred from the cathode to the anode through the electrons donated from the contained lung cancer phosphorus material; A detection unit for detecting electron movement of the sensor electrode unit; A display unit showing information on the detection of the lung cancer phosphorus substance; A power supply unit that supplies operating power to each component; And a control unit connected between the sensor electrode unit, the detection unit, and the display unit. A lung cancer sensor using exhalation, characterized in that it comprises and detects and displays lung cancer phosphorus substances in exhalation flowing into the sensor electrode unit.
The present invention has an effect capable of detecting lung cancer phospholipids using a precise detection technique of ppt level, and to accurately diagnose lung cancer and other cancers from the detected pulmonary cancer phospholipids. In particular, by using the ppt level molecular unit detection technology, there is an effect that can detect the early lung cancer that could not be detected with the existing technology.

Description

Lung cancer diagnostic sensor using breath}

The present invention relates to a lung cancer sensor capable of diagnosing whether lung cancer has occurred and whether cancer has occurred by detecting a lung cancer phosphorus substance (a substance generated due to lung cancer) contained in exhalation (呼氣, exhalation), in particular, lung cancer The energy level of the oxidation-reduction potential is designed to allow electrons to move from the cathode to the anode through the electrons donated by the source material, thereby enabling precise diagnosis on a molecular basis.

Despite the continued conquest of cancer due to the development of preventive diagnostic medicine, medical welfare, and medical technology, cancer is still a fatal threat to human health.

The incidence of cancer in Korea increased from an average of 3.6% per year from 1999 to 2012, when it began to calculate cancer incidence, and then declined by an average of 6.1% since 2012. In 2015, the number of cancer cases in Korea was about 215,000, with 421.4 per 100,000 population.

However, the cancer survival rate increased steadily, and the 5-year relative survival rate increased from about 40% in 1995 to about 70.7% in 2015. This indicates that 2 out of 3 cancer patients survive for more than 5 years. These results indicate that the incidence of cancer continues to increase, but the progression to malignancy is suppressed.

The most important thing to prevent cancer from being cured or progressing to malignancy is to detect cancer early. For example, in the case of gastric cancer, the mortality rate is gradually decreasing, which is presumed to be due to an increase in cure rate due to early treatment due to early cancer screening. On the other hand, the mortality rate of lung cancer is increasing from 28.7 in 2006 to 35.1 in 2016, which is presumed to be because early detection of lung cancer is difficult.

Lung cancer occurs in airy lungs, so it is not easy to detect early cancer with imaging equipment such as X-rays. In addition, since the lung is a portion in contact with air, the dissolved amount of blood, urine, which is a lung cancer-causing substance generated in lung cancer is extremely small, so it is not easy to detect the initial cancer with the existing technology. Therefore, most lung cancers are found in a state in which a lot has progressed, and the actual treatment golden time is missed. As a result, the survival rate is reduced due to the inability to treat.

In order to detect cancer early, the development of an ultra-precision sensor capable of detecting a very small amount of cancer phosphorus is urgently needed, and many studies have been continuously conducted for this.

1) Cantilever type precision sensor that detects the mechanical distortion caused by adsorption of the substance to be detected as a current value,

2) A semiconductor sensor type precision sensor that detects a change in resistance due to adsorption of a substance to be detected,

3) Precise sensor using an asymmetric ion movement analysis method that detects by passing a substance to be detected inside a fluctuating electric field so that only molecules having a specific mass cross-sectional ratio reach the detector.

4) Precise sensors using gene sensing methods that detect using the receptors of genetically engineered mice include such ultra-precision sensors,

5) Precision sensor using antigen-antibody reaction,

6) A precision sensor using a Kelvin probe method for sensing a gas is an example of such an ultra-precision sensor.

Republic of Korea Patent Registration No. 10-1755230 "Sensor for detecting multi-drug resistant cancer cells and a method for detecting multi-drug resistant cancer cells using the same", Korean Patent Application No. 10-2012-0081710 "Nitrogen produced from a conductive polymer thin film using a screen printing technique Method for manufacturing dope sensor for cancer diagnosis of doped graphene-based high-efficiency field effect transistor, "Korean Patent Application No. 10-2014-0022228" Patterned Carbon Nanotube Biosensor for Cancer Cell Biomarker Detection ", Republic of Korea Patent Registration 10-1705179 "Self-color detection type cancer diagnosis kit and method for providing information for diagnosis of cancer using the same", Korean Patent Application No. 10-2016-0091997 "Field effect colorectal cancer sensor", Korean Patent Registration No. 10-1478896 "Anti-cancer drug-treated biosensor for detection of cancer cells and its manufacturing method", Republic of Korea Patent Registration No. 10-0894800 "Lung cancer diagnosis SAW sensor", etc. It is an example of a cancer sensor.

However, in ~ ppb (. Parts per billion 1/10 -9) conventional techniques is that the detection accuracy ^{ppm (parts per million, 1/10 -6} ) level as described above, ppt (parts per trillion, 1/10 - ¹² ) There were problems such as precise measurement down to the level and difficulty in ultra-precision measurement in molecular units.

For example, in the case of detecting lung cancer phospholipids, a technique capable of detecting a trace amount of lung cancer phospholipids contained in breathing, blood, urine, or body fluids is required, but in the conventional case, the detection level is not accurate to ppt level. There were problems such as difficulty in detection and early cancer detection.

The object of the present invention is to solve the conventional problems as described above, and in particular, to achieve a ppt level by precisely detecting the lung cancer phosphorus material contained in the exhalation using the energy level of the redox potential in molecular units. It is to provide a new concept lung cancer sensor with precision and accuracy.

In addition, the present invention is to provide a lung cancer sensor capable of real-time detection by directly detecting lung cancer phosphorus through electron transfer (current) detection through electron donation from lung cancer phosphorus.

In addition, by using a mobile inducing substance (positive-side moving inducing substance, negative-side-side moving inducing substance) having various energy levels of redox potential to detect lung cancer-causing substances, the scope of detection is expanded and more precise detection is made. will be.

That is, the lung cancer phosphorus substance generated in the lung is detected through exhalation, and a high-accuracy lung cancer sensor with a detection accuracy of ppt level or higher is provided to detect almost 100% of the initial lung cancer.

The present invention is a lung cancer sensor capable of detecting early lung cancer and cancer by detecting at least ppt units of lung cancer phosphorus substances contained in exhaled air in breathing air, in particular, via electrons donated from lung cancer phosphorus substances contained in exhalation By designing the energy level of the sensor electrode part so that electrons move from the cathode to the anode, and analyzing the movement of the electrons detected by the sensor electrode part to diagnose the initial lung cancer, it is characterized in that it can accurately diagnose.

In addition, the energy level of the sensor electrode portion is determined using one or more moving inducing materials (hereinafter, referred to as "moving inducing materials") that relay electron movement from the cathode to the anode. Design and excitation energy (optical) so that electrons can excite from the Homo of the Valence Band (HOMO: Highest Occupied Molecular Orbital) to the Lowest Unoccupied Molecular Orbital (LUMO) of the Conduction Band Energy, thermal energy, etc.) to control the movement of electrons, so that more accurate detection is achieved.

In addition, by constructing a mobile inducing material with at least one of fullerene, fullerene salt, ion-containing fullerene, dye, or a complex of ion-containing fullerene and a dye, the oxidation-reduction potential is lowered and the quantum yield is reduced.數 率) to increase the detection range and improve the measurement sensitivity.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96, the ions contained in the ion-containing fullerene, lithium, sodium, potassium, cesium, magnesium, calcium, Or characterized in that any one of strontium, the pigment, poly-3-hexyl thiophene (P3HT), such as polythiophene, polyp-phenylene, polyp-phenylene vinylene, polyaniline, polypyrrole, PEDOT , P3OT, POPT, MDMO-PPV, MEH-PPV, or a polymer polymer or a derivative thereof.

The lung cancer phosphorus material is toluene (Toluene), 2,6-diisopropyl phenol (2,6-Diisopropylphenol) (propofol), 2-methylpyrazine (2-Methylpyrazine), cyclohexanone (Cyclohexanone), 2- It is characterized by being at least one of butanone, acetic acid, acetone, and acetonitrile.

According to the present invention, the lung cancer sensor using exhalation, in particular, can detect lung cancer including the initial state by detecting the lung cancer phosphorus substance contained in the exhalation at an accuracy of ppt level or higher using the energy level of the oxidation-reduction potential. It works.

In addition, by designing the energy level using a mobile inducing material, it has the effect of widening the detection range and increasing selectivity, and also improving the accuracy of lung cancer diagnosis.

In addition, the energy level of the redox potential is very low and the energy level is designed using ion-containing fullerenes and pigments having high quantum yield, thereby further extending the detection range and accuracy of cancer diagnosis.

The present invention has an effect capable of detecting lung cancer phospholipids using a precise detection technique of ppt level or higher, and to accurately diagnose lung cancer and other cancers from the detected pulmonary cancer phospholipids. In particular, by using a molecular unit detection technique of a ppt level or higher, there is an effect of detecting an early lung cancer that could not be detected with existing techniques.

1 is a block diagram showing a system configuration according to the present invention,
2 is a view showing the configuration of the sensor electrode portion of the present invention,
3 is a view showing the configuration of the sensor electrode unit according to an embodiment of the present invention,
4 is a view showing another configuration of the sensor electrode unit according to an embodiment of the present invention,
5 is a view showing another configuration of the sensor electrode unit according to an embodiment of the present invention,
6 is (a) is an ion-containing fullerene, (b) is a composition of a polymer in which an ion-containing fullerene and a pigment are bonded, (c) is a conceptual diagram showing an excited state of electrons due to light energy,
7 is a conceptual diagram showing that a fullerene-pigment polymer is electrophoresed on an anode,
8 is a view showing the energy level of the electron,
9 is a view showing an energy level design according to the present invention,
10 is a view showing another energy level design according to the present invention,
11 is a view showing another energy level design according to the present invention,
12 is a view showing another energy level design according to the present invention,
13 is a view showing another energy level design according to the present invention,
14 is a view showing another energy level design according to the present invention,
15 is a view showing another energy level design according to the present invention,
16 is a view showing another energy level design according to the present invention,
17 is a view showing another energy level design according to the present invention,
18 is a view showing another energy level design according to the present invention,
19 is a view showing another energy level design according to the present invention,
20 is a view showing another energy level design according to the present invention;
21 is a view showing another energy level design according to the present invention,
22 is a view showing another energy level design according to the present invention,
23 is a view showing an energy level design according to an embodiment of the present invention;
24 is a view showing another energy level design according to an embodiment of the present invention,
25 is a cross-sectional view showing the configuration of the aerobic collecting device according to the present invention,
Figure 26 (a) is a diagram showing a method of using the aerobic collecting device, (b) is a cross-sectional view showing the process of collecting the exhalation through the aerobic inlet pipe and the inlet opening and closing pipe, (c) is the aerobic collecting device A sectional view showing a mounting method, (d) a sectional view showing supply of the collected exhalation to the sensor electrode unit using an elastic restoring force, (e) a sectional view showing a supply of the collected exhalation unit to the sensor electrode unit using a fan,
27 is a circuit diagram conceptually showing the circuit configuration of the potentiometer,
28 is a view showing an example of the configuration of a measurement electrode,
29 is a graph showing a section enlargement of the CV graph,
30 is a graph showing an example of quantum yield according to wavelength.

The detailed description of the technical idea of the present invention is given as follows.

In describing the configuration and embodiments of the present invention, the same or similar names and symbols are used for components having the same or similar configurations and functions, and additional or overlapping or limited meanings of the invention can be interpreted. The description may be omitted in describing the embodiments of the present invention.

Prior to the detailed description, the concept of the invention, even though it is described in the singular expression in the specification, in light of the environment used without clearly distinguishing the singular / plural in the use of the Korean language and the environment used in common terms in the art It is used as a meaning that includes plural expressions, unless contrary to the interpretation and expressly contradicts otherwise. In addition, 'includes', 'haves', 'includes', 'includes' and the like described or may be described in the present specification means the existence or addition possibility of one or more other features or components or combinations thereof. It should be understood that it is not excluded in advance.

The configuration according to the technical concept of the present invention "a lung cancer sensor using exhalation," as shown in Figure 1, the energy level of the oxidation-reduction potential so that electrons move from the cathode to the anode via the lung cancer phosphorus material contained in the exhalation. Sensor electrode unit 120 is designed; An excitation energy supply unit 130 that supplies electron excitation energy to the sensor electrode unit; A detection unit 110 for detecting electron movement of the sensor electrode unit 120; A display unit 160 showing the detection contents of the detection unit 110; A data storage unit 140 that stores the detection contents of the detection unit; A communication unit 170 transmitting the detection information; A control unit 150 connected to the sensor electrode unit 120, the excitation energy supply unit 130, the detection unit 110, the data storage unit 140, the display unit 160, and the communication unit 170; And, it comprises a power supply unit 180 for supplying the operating power to each of the components, characterized in that the technical configuration that indicates by detecting the lung cancer phosphorus material in the exhalation flowing into the sensor electrode unit 120 .

In the present invention, when a patient's exhalation flows between the cathode and the anode of the sensor electrode unit 120, the sensor moves electrons from the cathode to the anode through the electrons donated by the lung cancer phosphor contained in the exhalation. The energy level of the redox potential of each component constituting the electrode is designed.

That is, the energy level is designed such that the number of electrons proportional to the lung cancer phosphorus material included in the exhalation moves from the cathode to the anode, and whether the electrons are present (whether or not current flows) is detected to determine whether the lung cancer phosphorus material is present. Determines whether or not, and detects the degree of lung cancer from the type and amount of lung cancer phosphorus substances by detecting the degree of electron movement (current amount) and accurately determines the amount of lung cancer phosphorus influx. It is stored in the storage unit 140, indicated through the display unit 160, and transmitted to an external device through the communication unit 170.

Since the movement of electrons is proportional to the number of molecules of the lung cancer phosphonate introduced, it is possible to detect the lung cancer phospholipid in a molecular unit, and real-time detection is possible by indicating the amount of the lung cancer phosphonate as the amount of current.

In the above configuration, as shown in Figure 25, it characterized in that it is configured to further include; aerobic collecting device 190 for collecting the exhalation of the subject.

The exhalation collecting device 190 is for easily collecting the exhalation of the subject and supplying it to the sensor electrode unit 120.

The lung cancer phospholipid is a lung cancer metabolite that is caused by cancer, and the discovery of the lung cancer phospholipid means that there are lung cancer cells in the body.

Toluene, 2,6-diisopropyl phenol, 2-methylpyrazine, cyclohexanone, 2-butanone, acetic acid, acetone , Acetonitrile, and the like. When a lung cancer phospholipid is detected, the type of the lung cancer tract substance is determined, and the proportion of each lung cancer phospholipid is determined to determine the degree of cancer progression.

The detection unit detects any one or more of Cyclic Voltammetry (CV), Chrono Amperometry (CA), or Chorono Potentiommetry (CP), or Striping Voltammetry (SV), or Linear Sweep Voltammetry (LSV) of lung cancer phosphorus. It is characterized by detecting the presence and amount of the substance.

That is, the presence and amount of a lung cancer killer is detected by measuring CV, or CA, or CP, or SV, or LSV of a lung cancer killer by using a potentiostat. do.

At this time, the exhaled collected exhalation is preferably used by diluting in a specific solvent.

FIG. 27 is a circuit diagram showing a simplified configuration of a potentiometer, and detects lung cancer phosphorus substances through a working electrode (W), a reference electrode (RE), and a counter electrode (CE). can do. That is, after constructing the working electrode (W) using a moving induction material (anode-side moving inducing material, cathode-side moving inducing material), after obtaining the CV, CA, CP, SV, LSV, etc. through the 3-electrode method or the 2-electrode method, By analyzing this, it is possible to accurately measure the presence and amount of lung cancer phosphorus substances.

The configuration and operation principle of the potentiometer used in the electrochemical field and the three-electrode method, two-electrode method, CV, CA, CP, SV, LSV, etc. are as well known, and detailed description thereof will be omitted.

The detector is characterized in that it detects the presence and amount of the lung cancer phosphor by detecting the quantum yield (IPCE: Incident Photon to Current Efficiency) according to the wavelength of the light source supplied by the excitation energy.

Figure 30 shows the quantum yield (IPCE) according to the wavelength of the light source, as shown in the figure, shows that the quantum yield according to the wavelength varies depending on the material. Therefore, it is possible to know whether a lung cancer phosphorus substance is present by using the properties of the quantum yield curvature. For example, the quantum yield graph of FIG. 30 (a) is the maximum at about 440 nm, has a second peak value at 560 nm, and a third peak value at 620 nm. This characteristic (peak value, wavelength, slope, peak interval, etc.) ) Can be used to find out whether or not a lung cancer factor is present.

Since the quantum yield measurement is well known, detailed description thereof is omitted.

The excitation energy supply unit 130 is any one of a light energy supply unit (not shown), an electromagnetic wave energy supply unit (not shown), or a thermal energy supply unit (not shown) that supplies energy equal to or greater than the band gap energy between the valence band and the conduction band. It is characterized by comprising the above.

The excitation energy supply unit 130 is configured to supply excitation energy using light energy, electromagnetic wave energy, or thermal energy. In some cases, two or more energy sources may be used together to configure excitation energy. For example, it can be configured to supply a predetermined size of excitation energy as light energy, and supply the remaining excitation energy as heat energy. It is preferable to use this configuration when it is not possible to supply excitation energy of a desired size with one energy source.

In the description, the concept of “electromagnetic waves” includes both heat and light, but is used for convenience of explanation.

The light irradiated from the light energy supply unit is characterized by being composed of one or more lights having different wavelengths and brightness.

The light source irradiated from the light energy supply unit is preferably composed of any one or more of an LED light source having different wavelengths, a laser light source having different wavelengths, a halogen lamp, a mercury lamp, or a xenon lamp.

The optical energy supply unit is designed to supply different band gap energy by designing the amount of excitation energy by wavelength or brightness. For example, when a plurality of positive electrode-side moving inducing materials or negative electrode-side moving inducing materials are used, and the band gap energy of the used mobile inducing materials is different, and it is necessary to separately supply each band gap energy, This can be achieved by adjusting the wavelength or brightness of the light supplied.

In this case, it is needless to say that the band gap energy can be supplied to all the mobile inducing materials by using one light separately from the above. That is, it can be configured to supply excitation energy to a plurality of mobile inducing materials using one light source that supplies energy greater than the largest bandgap energy.

Since the configuration and operation of the driving device for driving the different light sources are well known, detailed description thereof will be omitted.

The electromagnetic wave supplied from the electromagnetic wave energy supply unit is characterized by being composed of one or more electromagnetic waves having different wavelengths and intensities.

The electromagnetic wave energy supply unit is for supplying different band gap energy by designing the amount of excitation energy by wavelength or output intensity. For example, electromagnetic waves such as 1.0 GHz, 1.2 GHz, and 2 GHz can be used.

Since the configuration and operation of the electromagnetic wave generating device for supplying the different electromagnetic waves are as well known, detailed description thereof will be omitted.

The heat radiated from the thermal energy supply unit is characterized by being composed of one or more heats having different temperatures and intensities.

The thermal energy supply unit is for supplying different band gap energy by designing the amount of excitation energy with temperature and intensity. For example, it can be configured to supply heat, such as 1,000 ℃ heat, 1,500 ℃ heat.

Since the configuration and operation of the heat generating device for generating the heat are as well known, detailed description thereof will be omitted.

The display unit 160 is preferably configured to include a visual display unit 161 for visually indicating information on the detection of lung cancer phosphorus substances, and an auditory display unit 162 to be auditoryly displayed.

The communication unit 170, wired communication unit 171 for transmitting information on the detection of lung cancer phosphonates by wire (dedicated line, dedicated network, Internet, etc.), and information on the detection of lung cancer phosphonates by wireless (wireless communication, mobile communication, It is preferably composed of a wireless communication unit 172 to transmit over a short-range wireless communication, Wi-Fi, Bluetooth, etc.).

The sensor electrode unit 120 may be configured in various forms as follows according to the lung cancer phosphorus material to be detected.

<Sensor electrode part 1>

Configuration 1 of the sensor electrode according to the technical idea of the present invention, as shown in Figure 9, a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; And, an anode configured to have an oxidation-reduction potential lower than the energy level of the valence band of the lung cancer phosphorus material, including, when the lung cancer phosphorus material is introduced between the cathode and the anode, at the cathode via the lung cancer phosphorus material as a medium. It is characterized by its technical configuration that the energy level is set so that electron transfer is made to the anode.

The sensor electrode configured as described above is designed so that the energy level of the cathode is higher than that of the lung cancer-causing substance, and the energy level of the anode is designed to be lower than that of the lung cancer-causing substance, and the electron is transferred from the cathode to the anode through the electron donated from the lung cancer-causing substance. It was to enable the movement of the.

The relationship between the energy level c of the positive valence band, the energy level e of the valence band of the lung cancer substance, and the energy level a of the negative valence band is as follows.

Energy level of sensor electrode part 1: c <e, e <a

In the configuration of the sensor electrode part 1, when a lung cancer phosphorus material having an energy level between the energy level value of the cathode and the energy level of the anode flows in, the electrons in the valence band of the lung cancer phosphorus material have a lower energy level than themselves. The electrons move from the cathode to the positive electrode, and the electrons move from the cathode to the positive pole of the valence band of the lung cancer phosphorus material generated by the electrons transferred to the anode. As long as the lung cancer phosphorus substance is present, the number of electrons proportional to the lung cancer phosphorus substance is continuously Will move to

At this time, it is possible to determine whether or not there is a lung cancer phosphorus substance by detecting whether the electron has moved (current flows), and to accurately determine the amount of the lung cancer phosphorus substance by detecting the degree of electron movement (current amount). have.

In addition, it is determined whether or not lung cancer has occurred and whether other cancers have occurred from the type, amount, and composition ratio of the lung cancer-causing substance.

<Sensor electrode part 2>

As shown in FIG. 10, the sensor electrode unit 2 includes: a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material included in the exhalation; And an anode configured to have an oxidation-reduction potential lower than the energy level of the conduction band of the lung cancer phosphorus material, including, when the waste cancer phosphorus material is introduced between the cathode and the anode, the excitation energy supplied by the excitation energy supply unit The energy level is such that the electrons in the valence band of the lung cancer phosphorus material are excited by the conduction band, the electrons excited by the conduction band move to the anode, and the electrons move from the cathode to the positive holes formed in the valence band of the lung cancer phosphorus material. Characterized in that is set.

Energy level of sensor electrode part 2: c> e, e <a

The sensor electrode unit 2 configured as described above supplies excitation energy (eg, light) that is greater than the band gap energy of the valence band and conduction band of the lung cancer phosphorus material to the lung cancer phosphorus material to the valence band of the lung cancer phosphorus material Excited electrons are excited to the conduction band, and electrons excited to the conduction band are moved to the anode having an energy level lower than that of the conduction band. In addition, the electrons are moved from the cathode to the current through the holes generated in the valence band of the lung cancer phosphorus material, and the current is proportional to the number of molecules of the lung cancer phosphorus material by repeating the same process as long as the excitation energy is supplied. Is to flow.

In the configuration of the sensor electrode part 2, when the energy level of the positive electrode is higher than the energy level of the valence band of the lung cancer phosphorus material and the electron in the valence band of the lung cancer phosphorus material cannot move to the anode, the electron in the valence band of the lung cancer phosphorus material By exciting the conduction band, the excited electrons can be moved to the anode by using the energy level of the excited electrons.

Again, this is as follows.

As is well known, as shown in FIG. 8, a band filled with electrons is called a valence band, and its highest occupied orbit is called HOMO. In addition, a band in which the electron is empty is called a conduction band, the lowest orbit is called LUMO, and the energy between homo and lumo is called bandgap energy (Eg), and energy above this bandgap energy is When supplied, the electrons in the valence band can be excited by conduction bands.

As shown in FIG. 10, the sensor electrode unit configuration 2 of the present invention supplies energy equal to or greater than the band gap energy through the excitation energy supply unit 130 to excite electrons in the valence band of the lung cancer substance to conduction energy By increasing the level, electrons are transferred to the anode.

In the configuration of the sensor electrode portion, it is preferable that the anode or the cathode is made of a transparent electrode.

The transparent electrode is to allow the light irradiated from the excitation energy supply unit 130 to be transmitted through the lung cancer phosphor, and is irradiated with TCO (transparent conducting oxide), FTO (F-doped [SnO₂]: fluorine doped oxidation Transparent electrodes such as tin), ITO (Indium tin oxide), AZO (Al-doped ZnO: aluminum doped zinc oxide), and GZO (Ga-doped ZnO: gallium doped zinc oxide) may be used.

<Sensor electrode part configuration 3>

The configuration of the sensor electrode part 3, as shown in Figure 11, a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; And, the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the phosphorus substance, and the energy level of the redox potential of the conduction band is configured to have an energy level higher than the energy level of the redox potential of the anode. Consisting of a positive electrode side transfer inducing material, when a waste cancer phosphor is introduced between the negative electrode and the positive electrode, electrons in the valence band of the positive side mobile inducing material are conducted as excitation energy supplied from the excitation energy supply unit. Excitation, the electrons excited by the conduction of the anode-side mobile inducing material move to the positive electrode, and electrons in the valence band of the waste cancer-causing material move through the holes formed in the valence band of the positive-electrode moving inducing material, and the lung cancer is The energy level is set so that the process of electron transfer from the cathode to the hole formed in the valence band of the material is achieved. Characterized in that.

Energy level of sensor electrode part 3: c> e> g, e <a

As described above, the configuration of the sensor electrode unit 3 is further characterized by designing an electron movement path by further configuring an anode-side moving inducing material between the lung cancer phosphorus material and the anode.

In other words, the positive electrode side movement inducing material having a lower energy level than the energy level of the valence band of the lung cancer phosphorus material is further configured on the anode side, thereby designing an electron transport path through electrons donated from the lung cancer phosphorus material.

The positive electrode side transfer inducing material or negative electrode side transfer inducing material is characterized in that it is composed of any one or more of a fullerene, a fullerene salt, an ion-containing fullerene, a pigment, or an ion-containing fullerene and a polymer of a dye.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96.

The ion contained in the fullerene is characterized in that it is any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium.

The pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), polyp-phenylene, polyp-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV It is characterized in that it is at least one of a polymer polymer or a derivative thereof.

Figure 6 (a) shows that the ions are contained in the C60 fullerene, Figure 6 (b) shows the binding of the ion-containing fullerene and the pigment, Figure 6 (c) is a conceptual diagram showing the excitation of electrons by light energy to be.

Lithium-containing fullerenes have an advantage in that the energy level of the redox potential of the valence band is very low, thereby widening the range of lung cancer phosphorus substances to be detected.

In addition, lithium-containing fullerenes have the advantage of improving the measurement sensitivity due to high quantum yield.

The quantum yield refers to the ratio of the number of molecules that have actually undergone chemical changes in the photochemical reaction and the number of photons absorbed.

The positive electrode side transfer inducing material or negative electrode side transfer inducing material is characterized in that it is included in the positive electrode or the negative electrode using electrophoresis (電氣 泳 動, electrophoresis).

7 is a conceptual diagram showing an example in which the fullerene-pigment polymer 122c is electrophoresed on the anode 121a.

The positive electrode-side moving inducing material or negative-side moving inducing material may be used materials having energy levels of various redox potentials including [TiO₂], [Sn02], and more precise and accurate energy levels using these moving inducing materials Can design

<Sensor electrode part configuration 4>

The configuration of the sensor electrode part 4, as shown in Figure 12, a cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; And, the anode is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band has an energy level higher than the energy level of the redox potential of the anode. Side movement inducing material; including, when the waste carcinogen is introduced between the cathode and the anode, first, by the excitation energy supplied from the excitation energy supply unit electrons in the valence band of the cathode-side movement inducing material conduction band The electrons excited by the conduction of the anode-side transfer inducing material move to the anode, and second, the electrons in the valence band of the lung cancer phosphorus material are excited by the excitation energy supplied from the excitation energy supply unit. , The electrons excited by the conduction of the lung cancer phosphorus material are generated in the valence band of the anode-side moving inducing material. Moving to the positive hole, and third, the energy level is set so that the process of electron transfer from the cathode to the positive hole formed in the valence band of the lung cancer phosphor.

Energy level of sensor electrode part 4: c> g> e, e <a

In the configuration of the sensor electrode unit 4 configured as described above, in designing an electron movement path according to the influx of the lung cancer phosphor material, the lung cancer sensor is configured by exciting the electrons in the valence band of the lung cancer phosphor material and the anode-side transfer inducer as conduction bands. There are features.

<Sensor electrode part configuration 5>

As shown in FIG. 13, the configuration of the sensor electrode part 5 includes: a cathode configured to have an oxidation-reduction potential lower than the energy level of the valence band of the lung cancer phosphorus material included in the exhalation; An anode configured to have an oxidation-reduction potential lower than the energy level of the valence band of the lung cancer phosphorus material; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band is configured to have an energy level higher than the energy level of the valence band of the lung cancer material Consisting of a cathode-side moving inducing material; when a waste cancer-causing substance is introduced between the cathode and the anode, first, electrons in the lung cancer-causing substance move to the anode, and secondly, to the excitation energy supplied from the excitation energy supply unit. By doing so, electrons in the valence band of the cathode-side moving inducing material are excited by a conduction band, and electrons excited by conduction of the cathode-side moving inducing material are moved to the positive holes formed in the valence band of the material that is a lung cancer, and thirdly, the cathode side. The energy level is set so that the process of electron transfer from the cathode to the hole is formed in the valence band of the mobile inducer. It is characterized by being determined.

Energy level of sensor electrode part 5: c <e, e> a> i

The configuration of the sensor electrode unit 5 configured as described above is characterized in that, when the energy level of the lung cancer-causing material is higher than that of the cathode, smooth electron movement can be performed by the cathode-side moving inducing material.

<Sensor electrode part configuration 6>

The configuration of the sensor electrode part 6, as shown in Figure 14, a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; An anode configured to have an oxidation-reduction potential lower than the energy level of the conduction band of the lung cancer phosphorus material; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band is configured to have an energy level higher than the energy level of the valence band of the lung cancer material Consisting of a cathode-side transfer inducing material; when a waste cancer phosphor is introduced between the cathode and the anode, first, the electrons in the valence band of the waste cancer phosphor are excited by conduction energy supplied from the excitation energy supply unit. And, the electrons excited by the conduction band of the lung cancer-causing material move to the anode, and secondly, the electrons in the valence band of the cathode-side moving inducing material excite by the conduction band by the excitation energy supplied from the excitation energy supply unit. Electrons excited by the conduction of the cathode-side transfer-inducing material are holes formed in the valence band of the material that is a lung cancer. Moving, third, it is characterized in that the energy level is set so that the process of electron transfer from the cathode to the positive hole formed in the valence band of the cathode-side transfer inducing material.

Energy level of sensor electrode part 6: c> e, e> a> i

The sensor electrode unit 6 configured as described above constitutes a lung cancer sensor by exciting the electrons in the valence band of the lung cancer phosphor and the cathode-directed inducer as conduction bands in designing the electron transport path according to the inflow of lung cancer phosphor. There are features.

<Sensor electrode part configuration 7>

As shown in FIG. 15, the sensor electrode unit 7 includes a cathode configured to have an oxidation-reduction potential lower than the energy level of the valence band of the lung cancer phosphorus material included in the exhalation; An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; The anode level is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. Moving inducers; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band is configured to have an energy level higher than the energy level of the valence band of the lung cancer material Consisting of a cathode-side moving inducing material, when a waste cancer phosphor is introduced between the cathode and the anode, first, electrons in the valence band of the cathode-side moving inducing material by the excitation energy supplied from the excitation energy supply unit Is excited by the conduction band, and the electrons excited by the conduction band of the anode-side transfer inducing material move to the anode, and secondly, electrons in the valence band of the lung cancer-causing material move through the holes formed in the valence band of the positive-side transport inducing material. And, third, the home appliance of the cathode-side moving inducing material by the excitation energy supplied from the excitation energy supply unit The electrons in the self-excitation band are excited by the conduction band, and the electrons excited by the conduction band of the cathode-side transfer inducing material move to the positive holes formed in the valence band of the lung cancer phosphorus material. It is characterized in that the energy level is set so that the process of electron transfer from the cathode to the positive hole is achieved.

Energy level of sensor electrode part 7: c> e> g, e> a> i

The configuration of the sensor electrode unit 7 configured as described above is characterized in that a lung cancer sensor is configured by designing an electron movement path according to the inflow of waste cancer phosphor using the anode-side moving inducing material and the cathode-side moving inducing material.

<Sensor electrode part configuration 8>

The configuration of the sensor electrode unit 8, as shown in Figure 16, a cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; The energy level of the oxidation-reduction potential of the valence band is lower than the energy level of the conduction band of the lung cancer phosphorus material, and the energy level of the oxidation-reduction potential of the conduction band is higher than the energy level of the oxidation-reduction potential of the anode. Inducers; And, the energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, the energy level of the redox potential of the conduction band is configured to have an energy level higher than the energy level of the valence band of the lung cancer material Consisting of a cathode-side moving inducing material, when a waste cancer phosphor is introduced between the cathode and the anode, first, electrons in the valence band of the cathode-side moving inducing material by the excitation energy supplied from the excitation energy supply unit Is excited by a conduction band, and electrons excited by the conduction of the anode-side moving inducing material move to the anode, and secondly, electrons in the valence band of the lung cancer phosphorus material are conducted by the excitation energy supplied from the excitation energy supply unit. Excitation, and the electron excited by the conduction of the lung cancer-causing material is a valence band of the anode-side moving inducing material The electrons in the valence band of the cathode-side moving inducing material are excited by a conduction band, and the electrons excited by the conduction of the cathode-side moving inducing material are transferred to the generated positive holes. It is characterized in that the energy level is set so that the process moves electrons from the cathode to the positive holes formed in the valence band of the lung cancer phosphorus material, and fourth, the positive holes formed in the valence band of the cathode-side transfer inducing material.

Energy level of sensor electrode part 8: c> g> e, e> a> i

In the configuration of the sensor electrode unit 8 configured as described above, in designing an electron movement path according to the inflow of waste cancer material using the anode-side moving inducing material and the cathode-side moving inducing material, the anode-side moving inducing material and the cathode-side moving inducing material And a lung cancer sensor by exciting the lung cancer phosphorus substance.

In constructing the sensor electrode parts, the positive electrode side movement inducing material that induces the movement of the donated electrons from the material that is donated to the positive electrode is composed of one or more.

When a plurality of positive electrode-side transfer-inducing materials are configured in the above configurations, as shown in FIGS. 17 to 18 and 21 to 22, the first positive-electrode-side transport induction that receives electrons from the lung cancer phosphorus material The energy level of the conduction band of the material is set higher than the energy level of the valence band of the next anode-side transfer-inducing material, and the energy level of the conduction band of the last anode-side shift-inducing material donating electrons to the anode is the energy level of the anode. Set higher, and the energy level of the anode-side mobile inducer in the intermediate step is set to be higher than the energy level of the valence band in the cathode-side mobile inducer in the next step. It is characterized in that the level is set lower than the energy level of the conduction band of the anode-side transfer inducer in the previous stage.

This configuration is to enable the detection of lung cancer-causing substances by using a plurality of anode-side transfer-inducing substances, thereby enabling more accurate energy level design for lung cancer-causing substances.

In constructing the sensor electrode parts, the cathode-side moving inducing material that induces the transfer of electrons donated from the cathode to the waste cancer-causing material is composed of at least one.

In the above configuration, when a plurality of cathode-side moving inducing materials are configured, as shown in FIGS. 19 to 22, the energy level of the conduction band of the first cathode-side moving inducing material donating electrons from the cathode is The energy level of the conduction band of the last cathode-side mobile inducer is set to be higher than the energy level of the valence band of the next negative-electrode-shifting material, and the electrons are donated with holes formed in the valence band of the waste-carcinogen. Set higher than the energy level of the valence band, and the energy level of the cathode-side mobile inducer in the intermediate stage, set the energy level of the conduction band higher than the energy level of the cathode-side mobile inducer in the next stage. , Characterized in that the energy level of the valence band is set lower than the energy level of the conduction band of the cathode-side transfer inducer in the previous stage. It shall be.

This configuration is to enable the detection of lung cancer-causing substances by using a plurality of cathode-side transfer-inducing substances, thereby enabling more accurate energy level design for lung cancer-causing substances.

The aerobic collecting device 190, as shown in Figure 25, aerobic pockets (193) in which exhalation is collected; The exhalation pocket (193) is provided therein, the quantitative envelope (194) for limiting the amount of exhalation collected in the exhalation pocket (193); An exhalation inlet pipe 191 provided on one side of the exhalation pocket 193, in which a subject bites into the mouth and blows exhalation; And, it is provided on the other side of the exhalation pocket 193, the exhalation outlet pipe 196 for supplying the collected exhalation to the sensor electrode unit 120; characterized in that it comprises a.

The exhalation inlet pipe 191 further includes an inflow opening / closing means 192 which is a unidirectional opening / closing means that is opened only in the direction of the internal collection portion 195 of the exhalation pocket 193, and the exhalation inflow pipe 196 is equipped with a sensor. It is preferable to further include an outlet opening / closing means 197 which is a unidirectional opening / closing means that is opened only in the inner direction of the electrode portion 120.

Hereinafter, the technical idea of the present invention "a lung cancer sensor using exhalation" will be described in detail with reference to examples.

In describing, the same or similar names and symbols are used for the components having the same or similar configuration and function.

<Example 1>

In Example 1, description will be given by detecting 2,6-diisopropylphenol, which is one of the lung cancer-causing substances that appear when lung cancer occurs.

In the first embodiment, an FTO (F-doped [SnO₂]) transparent electrode is used as an anode, and platinum (Pt) is used as an anode.

In addition, in Example 1, it will be described taking as an example the use of fullerene [C60] as the anode-side transfer inducing material.

Therefore, the sensor electrode according to the first embodiment is constructed by using FTO as an anode, electrophoresis [C60] on the FTO, and platinum (Pt) as a cathode. In addition, the excitation energy supply unit for supplying the excitation energy to the anode-side transfer inducing material is further configured, and the excitation energy supply unit will be described as an example of supplying light energy.

In addition, in the first embodiment, when a waste cancer substance (2,6-diisopropyl phenol) is introduced into the sensor electrode, a detection unit for detecting the flow of electrons moving from the cathode to the anode, and detection information (detection process, A description will be given taking an example comprising a display unit for displaying detection conditions, detection results, etc., a data storage unit for storing it, and a communication unit for exchanging information about the detection with an external device.

In addition, in this Example 1, it demonstrates as an example which detects the 2,6- diisopropyl phenol contained in exhalation (expiration). Therefore, it will be described as an example that the sensor electrode portion is configured as a structure in which exhalation can flow between the cathode and the anode. Exhalation (exhalation) containing the lung cancer phosphorus material is supplied to the sensor electrode unit using a pumping device.

In addition, in the first embodiment, the exhalation collecting device will be described as an example in which an exhalation pocket is provided inside the quantitative envelope, and the inflow opening / closing means and the outflow opening / closing means are constituted by a unidirectional valve in the exhalation inlet pipe and the exhalation outlet pipe.

The reason for configuring the first embodiment as described above is that other configurations and embodiments according to the technical spirit of the present invention can be easily seen from the present embodiment.

 Hereinafter, the configuration of the first embodiment configured as described above will be described in detail with reference to the accompanying drawings.

1) Construction of aerobic collecting device

As shown in FIG. 25, the aerobic collecting device 190 fits the exhalation pocket 193 inside the quantitative sheath 194, and exhalation inlet pipe 191 and inflow opening and closing means on one side of the exhalation pocket 193. It is provided with (192), it is configured to include the exhalation outlet pipe 196 and the outlet opening and closing means (197) on the opposite side.

2) Energy level design of sensor electrode part

The energy level design process of this example 1 for detecting 2,6-diisopropyl phenol will be described with reference to FIG. 23 as follows.

The energy level based on the valence band of the valence band of 2,6-diisopropyl phenol, a lung cancer substance, is -5.93 eV, and the energy level of the conduction band is -0.01 eV. Therefore, the energy level of the negative electrode requires an electrode having an energy level higher than -5.93 eV, which is the valence band of the valence band 2,6-diisopropylphenol. In the first embodiment, platinum (Pt) having an energy level of -5.93 eV in the valence band and -5.12 eV in the conduction band is used as a cathode. Therefore, when 2,6-diisopropylphenol, a lung cancer-causing substance, comes into contact with a cathode made of platinum (Pt), electrons can move from the cathode to a hole formed in the valence band of the 2,6-diisopro- filphenol, a cancer-causing substance. It will have an energy level structure.

2,6-diisopropyl phenol, a lung cancer-causing substance detected in Example 1, has a low energy level of -5.93 eV in the valence band, and thus a positive electrode side-shifting material having a lower energy level is required. In the first embodiment, [C60] having a valence band energy level of -6.72 eV is used as a positive electrode transfer inducer. The energy level of the valence band of [C60] used as the anode-side transfer inducing material is lower than the energy level of the valence band of the lung cancer substance 2,6-diisopropyl phenol, -5.93eV, and the 2,6-di The electron in the valence band of soprofilphenol has an energy level structure that can be moved to the positive holes in the valence band of [C60].

Since the energy level of the conduction band of [C60], which is the anode-side moving inducing material, is -3.89 eV, and the energy level of the valence band of the FTO used as the anode is -4.85 eV, electrons excited to the conduction band of [C60] are positive. You will have an energy level structure that can be moved to.

That is, when the conditions are satisfied, electrons excited to the electron beam of the positive electrode side shift-inducing substance [C60] move to the positive electrode, and 2,6- which is a lung cancer-causing substance due to a hole generated in the valence band of [C60]. Electrons of diisopropyl phenol move, and holes generated in the valence band of 2,6-diisopropyl phenol have an energy level in which electrons move in platinum (Pt) as a cathode.

Here, power of 2.83 eV or more of a light source having a wavelength of 438 nm is required for excitation of [C60], which is the anode-side transfer inducer. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp meeting the above conditions can be used.

Figure 23 shows the energy level and the corresponding material designed through the above process, as shown in the figure, when the lung cancer substance, 2,6-diisopropylphenol is introduced, one excitation process according to the energy level It is designed to allow electrons to move from the cathode to the anode.

3) Configuration of sensor electrode

As illustrated in FIG. 3, the positive electrode 121 and the negative electrode 124 are mounted inside the case 125 to configure the sensor electrode unit 120 according to the first embodiment.

The positive electrode 121 and the negative electrode 124 are supplied with operating power through a power supply unit 180, and a detector 110 is connected to detect a current flowing between the positive electrode 121 and the negative electrode 124. .

The case 125 is composed of a transparent electrode (121), which is a transparent electrode, or a whole case made of a transparent material (for example, glass, quartz, etc.). The light supplied from the light source 131, which is the excitation energy supply unit 130, is provided. The transparent electrode is configured to be irradiated to the anode 121.

As illustrated in FIG. 4, the case 125 may be configured such that a portion on which an anode is mounted is cut so that light irradiated from the light source 131 directly irradiates the transparent electrode to the anode 121.

In the figure, reference numeral 122 denotes exhalation (expiration), which includes a positive electrode-side transfer inducer, and (1) a lung cancer-causing substance 2,6-diisopropylphenol.

The exhalation (exhalation) 1 passes through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120, and detailed description thereof will be omitted.

As illustrated in FIG. 26, the sensor electrode unit 120 configured as described above is coupled to the aerobic collecting device 190 through a coupling structure.

4) System configuration

As shown in FIG. 1, the light source 131 of the excitation energy supply unit 130 can be irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect according to the first embodiment. Make up the system. The power supply unit 180 supplies operating power to each component.

The control unit 150 is preferably composed of a microprocessor, or a computer system, and the data storage unit 140 is composed of an internal memory of the control unit 150 or an external memory controlled by the control unit 150. desirable.

The data storage unit 140 stores a result of detection of 2,6-diisopropyl phenol, a lung cancer-causing substance, and a data table showing a correlation between the amount of 2,6-diisopropyl phenol and the amount of current.

Hereinafter, the operation of the first embodiment configured as described above will be described in detail as follows.

First, as shown in Fig. 26, exhalation is collected. When the subject is biting and blowing the exhalation inlet pipe 191 into the mouth as shown in (a), the inflow opening and closing means 192 is opened by the blowing force as shown in FIG. 26 (b), and the exhalation pocket 193 As this swells, exhalation is collected in the collection space 195.

Thereafter, as shown in FIG. 26 (c), the aerobic collecting device 190 is attached to the sensor electrode unit 120. Then, the aerobic induction pipe 127 is opened to the outflow opening / closing means 197 provided in the aerobic inflow pipe 196, and the exhalation is supplied to the sensor electrode unit 120 through the aerobic induction pipe 127.

FIG. 26 (d) shows that when the exhalation pocket 193 is made of an elastic material such as rubber, the exhalation flows out through the exhalation induction pipe 127 by its elastic force, and FIG. 26 (e) When the exhalation pocket 193 is made of a non-stretchable material such as vinyl, it indicates that exhalation is supplied to the sensor electrode unit 120 through the fan 126.

The exhalation is preferably using a fan 126, as shown in Figure 26 (e). When the fan 126 is used, it is possible to control the amount of expiration and whether it is supplied.

When the exhaled air collected in the exhalation collecting device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, and when the light source 131 of the excitation energy supply unit 130 is turned on, the The light energy irradiated from the light source 131 supplies excitation energy to [C60], the anode-side moving inducing material 122.

Then, the electrons in the valence band of the anode-side moving inducing material [C60] are excited to the conduction band, and a hole is generated in the valence band of [C60]. The energy level of the electron excited with the conduction band of [C60] is -3.89 eV, which is higher than the energy level of the valence band of the positive FTO -4.85 eV, so that the electron excited with the conduction band moves to the positive FTO.

In this state, when the 2,6-diisopropyl phenol, a lung cancer-caused substance contained in the exhalation, flows between the FTO as a positive electrode and platinum (Pt) as a negative electrode, it is in the valence band of the 2,6-diisopropyl phenol. The electron (energy level: -5.93 eV) moves to the positive hole (energy level: -6.72 eV) formed in the valence band of the positive electrode side transfer-inducing material [C60], and the valence band of the 2,6-diisopropylphenol A hole is produced.

Then, a hole (energy level: -5.93 eV) formed in the valence band of the lung cancer-causing substance 2,6-diisopropyl phenol is an electron (energy level: -5.93 eV) in the valence band of the platinum (Pt) as a cathode. Will move.

Thereafter, as long as excitation energy is supplied from the excitation energy supply unit 130, the same process is repeated, so that the number of electrons proportional to the number of molecules of the lung cancer-causing substance 2,6-diisopropyl phenol is repeated from the cathode to the anode. Will continue to move.

The detection unit 110 detects a current (electron movement) flowing between the cathode and the anode.

The control unit 150 detects whether or not current flows through the detection unit 110 to determine whether 2,6-diisopropyl phenol, a lung cancer-causing substance, is present, and is a waste cancer-causing substance from the amount of current. The amount of 2,6-diisopropyl phenol is determined. That is, by comparing the detected amount of current with a data table showing the relationship between the amount of current and the amount of lung cancer stored in the data storage unit 140, it is calculated how much 2,6-diisopropyl phenol has been introduced.

Subsequently, the control unit 150 stores information on the detection (detection process, detection conditions, detection results, etc.) in the data storage unit 140 and displays it through the display unit 160, through the communication unit 170. It is exchanged with an external device, and the process of repeating this process is used to continuously detect lung cancer phosphorus substances.

At this time, by detecting the current flowing through the electrons donated from the lung cancer phospho matter, it is possible to perform accurate and precise detection proportional to the number of molecules of the lung cancer phospho matter.

In other words, the presence or absence of a cancer-causing agent contained in exhalation detects the presence or absence of cancer cells, and the progress of cancer is determined by the amount of a cancer-causing agent. The type of cancer is determined by the composition ratio of two or more lung cancer substances detected in the same sample.

The degree of cancer progression is determined by referring to the data table indicating the amount of lung cancer phospholipids and the degree of cancer progression, and the type of cancer is determined by referring to the composition ratio of lung cancer phospholipids and the data table for the cancer type.

The precision of the lung cancer sensor is as follows.

The number of molecules contained in the exhalation of about 500 cc is about 1.19 × 10 ²² .

The number of molecules contained in 1 ppt of 500 cc of exhalation is,

1.19 × 10 ²² × 10 ^-12 = 1.19 × 10 ¹⁰ .

If this is expressed as the amount of charge,

(1.19 × 10 ¹⁰ ) × (1.62 × 10 ^{) -19} C) = about 1.19 × 10 ^-9 C = 1.9nA.

That is, even if the lung cancer phosphorus substance is contained in 1 cc of 500 cc of exhalation, it can be detected.

If it is said that 1% of lung cancer phosphorus is contained in the air of 1 ppt among 500 cc of exhalation, the charge amount is about 19 pA.

The configuration of the detection unit 110 for detecting the amount of charge in units of the nanoampere (nA) or picoampere (pA) is the same as well-known, and thus detailed description thereof will be omitted.

On the other hand, [C60] fullerenes and lithium ion-encapsulating fullerenes constituting the mobile inducing materials (anode-side mobile inducing materials, negative-side mobile inducing materials) in the present invention have an electron beam size of about 1 nm, and the lithium ion-containing fullerenes. The size of the supramolecular composed of pigment is about 2 nm.

Therefore, if it is said that there is a 1ppt lung cancer phosphorus material in the 500cc unit, and the mobile inducing material is composed of supramolecular molecules (about 2nm) composed of lithium-ion-containing fullerene and a pigment, the size of the electrode plate to which the lung cancer phosphorus material reacts at the same time is A size of about (0.22mm ㅧ 0.22mm) is sufficient. When there is 1% of lung cancer phosphorus material in the exhalation of 1 ppt among the 500 cc, a positive electrode (or a negative electrode) may be formed of a smaller sized electrode plate.

That is, a lung cancer sensor having a precision of ppt level or more can be constructed by allowing a number of electrons proportional to the number of molecules of the lung cancer phosphor to move, and directly detecting the number of transferred electrons.

<Example 2>

In the second embodiment, it will be described as an example of detecting toluene, which is one of the lung cancer-causing substances that appear when lung cancer occurs.

In Example 2, as in Example 1, FTO was used as the anode, and platinum (Pt) was used as the cathode.

In addition, titanium dioxide (Titanium dioxide, [TiO₂]) and a positive electrode cheukje 1 Li-containing fullerene hexafluorotitanate phosphate salts In the anode cheukje second mobile inducer to the second embodiment ^- with the ^{([Li + @ C60] [} PF6]) This will be described as an example.

Thus using FTO as a sensor electrode unit anode according to the present embodiment 2, in the FTO [TiO₂] and ^{[Li + @ C60] [PF6} -] a and electrophoresis, constitutes using a platinum (Pt) as the cathode . In addition, the [TiO₂] and ^{[Li + @ C60] [PF6} -] will be described by configuring further comprises an excitation energy supply for supplying the excitation energy and to supply the light energy where the energy supply is an example.

In addition, in the second embodiment, as in the first embodiment, a description will be given as an example of having a detection unit, a display unit, a data storage unit, and a communication unit, and the toluene contained in exhalation (expiration) will be described as an example. .

The reason for configuring the second embodiment is that other configurations and embodiments according to the technical idea of the present invention can be easily seen from the present embodiment.

 Hereinafter, the configuration of the second embodiment will be described in detail with reference to the accompanying drawings.

1) Construction of aerobic collecting device

As in Example 1, the quantitative envelope 194 is fitted inside the exhalation pocket 193, the exhalation pocket 193 is provided with an exhalation inlet pipe 191 and inlet opening and closing means 192, the opposite side It is configured to be equipped with an exhalation outlet pipe 196 and the outlet opening and closing means (197).

2) Energy level design of sensor electrode part

The energy level design process of the second embodiment for detecting toluene will be described with reference to FIG. 24 as follows.

The energy level based on the valence band of the valence band of toluene, a lung cancer substance, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, an electrode having an energy level higher than the energy level of -6.55eV, which is the energy level of the valence band of the toluene, which is the lung cancer-based material, is required. In the second embodiment, platinum (Pt) having an energy level of -5.93 eV in the valence band and -5.12 eV in the conduction band is used as a cathode. Therefore, when toluene, a waste cancer-causing substance, comes into contact with a cathode made of platinum (Pt), it has an energy level structure that allows electrons to move from the cathode to a hole formed in the valence band of the toluene, a cancer-causing substance, by the energy level difference.

The toluene, a lung carcinogen that is detected in Example 2, has a very low energy level of -6.55 eV in the valence band, so a positive electrode-side transfer inducing material having a lower energy level is required. In the second embodiment, [Li + @ C60] [PF6-] having a valence band energy level of -7.70eV is used as the positive electrode side migration inducer. The energy level of the valence band of [Li + @ C60] [PF6-], which is used as the anode side transfer agent, is lower than the energy level of the valence band of the toluene, the lung cancer substance, -6.55eV, to the valence band of the toluene. It has an energy level structure that can move electrons to the positive holes in the valence band of [Li + @ C60] [PF6-].

Since the energy level of the conduction band of [Li + @ C60] [PF6-], which is the positive electrode side migration agent 1, is -4.90eV, and the energy level of the valence band of the FTO used as the anode is -4.85eV, the [Li + @ C60 ] Electrons in the conduction band of [PF6-] cannot move directly to the anode. Therefore, a positive electrode secondary transfer inducer is required to mediate this.

Since the positive electrode side first induction material [Li + @ C60] [PF6-] has an energy level of -4.90eV in the conduction band, and the positive electrode FTO has a valence band energy level of -4.85eV, the positive side second mobile induction material is -4.90. A material consisting of a valence band with an energy level lower than eV and a conduction band with an energy level higher than -4.85eV is required.

Since titanium dioxide ([TiO₂]) has an energy level of -6.21eV in the valence band and an energy level of -3.21eV in the conduction band, this [TiO₂] is used as a positive electrode secondary transfer inducer. do. Then, the electron excited in the conduction band of [TiO₂] has an energy level structure capable of moving to the anode.

That is, when the conditions are satisfied, the electrons excited in the electron band of the positive electrode side second transfer inducing material [TiO₂] move to the positive electrode, and the positive electrode side first inducing material [is the positive hole generated in the valence band of [TiO₂]. Electrons excited to the conduction band of Li + @ C60] [PF6-] move, and electrons of toluene, a lung cancer-causing agent, move to the positive holes generated in the valence band of [Li + @ C60] [PF6-], and the home appliances of the toluene It is a hole generated in the stool and has an energy level in which electrons move from platinum (Pt), the cathode.

The positive electrode side first inducer [Li + @ C60] [PF6-] requires a power of 2.8 eV or higher as a light source having a wavelength of 457 nm, and the positive electrode side second induce material [TiO₂] has a wavelength of 413 nm. A light source having a power of 3.0 eV or more is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions.

Figure 24 shows the energy level and the corresponding material designed through the process as described above, as shown in the figure, when the toluene, a cancer-causing substance, is introduced, the electrons from the cathode to the anode through two excitation processes according to the energy level It is designed to move.

3) Configuration of sensor electrode

As illustrated in FIG. 5, the positive electrode 121 and the negative electrode 124 are mounted inside the case 125, and operating power is supplied to the positive electrode 121 and the negative electrode 124 through a power supply unit 180. , A sensor electrode unit 120 according to the second embodiment is configured by connecting a detection unit 110 to detect a current flowing between the anode 121 and the cathode 124.

In the case 125, the surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material, so that the light supplied from the light source 131 which is the excitation energy supply unit 130 is a transparent electrode, the anode 121. To be investigated.

In the drawing, reference numerals (122a) denote a positive electrode side 1 mobile inducing material, (122b) denotes a positive electrode side 2 mobile inducing material, and (1) denotes exhalation (exhalation) containing toluene, a cancer-causing agent.

The exhalation (exhalation) 1 is configured to pass through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120.

4) System configuration

As shown in FIG. 1, the light source 131 of the excitation energy supply unit 130 can be irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 are connected to the control unit 150 to detect according to the second embodiment. Make up the system. The power supply unit 180 supplies operating power to each component.

The data storage unit 140 stores a toluene detection result and a data table showing the correlation between the amount of toluene and the amount of current.

Hereinafter, the operation of the second embodiment configured as above will be described in detail as follows.

When the exhaled air collected in the exhalation collecting device 190 flows into the sensor electrode unit 120 through the exhalation induction pipe 127, and when the light source 131 of the excitation energy supply unit 130 is turned on, the The light energy irradiated from the light source 131 is to supply excitation energy to [Li + @ C60] [PF6-], which is the positive electrode side first transfer inducing material 122a, and [TiO₂], which is the positive side second transfer inducing material 122b. do.

Then, the electrons in the valence band of [TiO₂], which is the positive electrode side second transfer inducing material, are excited to conduction bands, and holes are generated in the valence band of [TiO₂]. The energy level of the electron excited by the conduction band of [TiO₂] is -3.21 eV, which is higher than the energy level of the valence band of the positive FTO -4.85 eV, so that the electron excited by the conduction band moves to the positive FTO.

The electrons in the valence band of [Li + @ C60] [PF6-], the positive electrode side first transfer inducing material, are excited by the conduction band by the light energy irradiated from the light source 131, and the [Li + @ C60] [PF6-] A hole is formed in the valence band of. The energy level of the electron excited by the conduction band of [Li + @ C60] [PF6-] is -4.90eV, which is higher than the energy level of -6.21eV, which is the valence band of the anode-side second transfer inducer [TiO₂], The excited electrons move to the positive holes formed in the valence band of [TiO₂].

In this state, when the toluene, a lung cancer-causing substance, flows between the positive electrode FTO and the negative electrode platinum (Pt), electrons (energy level: -6.55eV) in the valence band of the toluene are the positive electrode side migration first substances. [Li + @ C60] [PF6-] is moved to a hole formed in the valence band (energy level: -7.70 eV), and a hole is generated in the valence band of the toluene.

Then, the electrons (energy level: -5.93 eV) in the valence band of platinum (Pt), which is the cathode, move to the positive holes (energy level: -6.55 eV) formed in the valence band of the toluene, which is the lung cancer substance.

Thereafter, as long as excitation energy is supplied from the excitation energy supply unit 130, the same process is repeatedly performed, so that a number of electrons proportional to the toluene, which is the lung cancer phosphorus material, is continuously moved from the cathode to the anode.

The detection unit 110 detects a current (electron movement) flowing between the cathode and the anode.

The control unit 150 detects whether or not current flows through the detection unit 110 to determine whether toluene, a lung cancer-causing substance, exists, and determines the amount of toluene, a cancer-causing substance, from the amount of current. . That is, the amount of toluene introduced is calculated by comparing the detected amount of current with a data table showing the relationship between the amount of waste cancer phosphorus material stored in the data storage unit 140 and the amount of current.

Subsequently, the control unit 150 stores information on the detection (detection process, detection conditions, detection results, etc.) in the data storage unit 140 and displays it through the display unit 160, through the communication unit 170. It is exchanged with an external device, and the process of repeating this process is used to continuously detect lung cancer phosphorus substances.

At this time, by detecting the current flowing through the electrons donated from the lung cancer phospho matter, it is possible to perform accurate and precise detection proportional to the number of molecules of the lung cancer phospho matter.

That is, the presence or absence of toluene, which is a lung cancer prognostic substance, detects the presence or absence of cancer cells, and determines the degree of cancer progression by the amount of the lung cancer prognostic substance. The type of cancer is determined by the composition ratio of two or more lung cancer-causing substances detected in the same sample (e.g., the composition ratio of toluene and 2,6-diisopropyl phenol, or toluene, 2,6-diisopropyl phenol, 2 -Composition ratio of methyl pyrazine, cyclohexanone, etc.)

The degree of cancer progression is determined by referring to the data table indicating the amount of lung cancer phospholipids and the degree of cancer progression, and the type of cancer is determined by referring to the composition ratio of lung cancer phospholipids and the data table for the cancer type.

However, in the above embodiments, it has been described as an example of detecting a lung cancer triggering substance using two anode-side moving inducing substances, but the technical spirit of the present invention is not limited to this. That is, the arm sensor of the present invention may be configured without a moving inducing material, or the arm sensor of the present invention may be configured using a plurality of anode-side moving inducing materials or a plurality of cathode-side moving inducing materials, or as many anodes as necessary. It turns out that the cancer sensor according to the present invention can be constructed by using both the mobile inducing material and the required number of negative side mobile inducing materials. 2 is a view showing a configuration example of a sensor electrode part using both the anode-side moving inducing material 122 and the cathode-side moving inducing material 123.

In addition, in the above embodiments, the excitation energy supply unit is configured to supply light energy, and it has been described as an example in which the light source is limited to one, but the technical spirit of the present invention is not limited to this. That is, it is revealed that the excitation energy supply unit can be configured using several different light sources, and can be configured to supply excitation energy using different energy sources.

In addition, in the above embodiments, it has been described as an example of detecting each of the lung cancer phosphorus substances, but it is revealed that the technical idea of the present invention is not limited thereto. That is, it is revealed that it can be configured to detect a plurality of lung cancer phosphorus substances. For example, it is revealed that it can be configured to detect two or more lung cancer phosphorus substances simultaneously using a plurality of anode-side moving inducing substances or a plurality of cathode-side moving inducing substances and a plurality of excitation energy supplying units.

In addition, in the present embodiments, the technical idea of the present invention has been described by taking as an example the detection of toluene and 2,6-diisopropyl phenol among lung cancer phospholipids, but the technical spirit of the present invention is not limited thereto. In other words, it is revealed that it can be configured to detect toluene, 2,6-diisopropylphenol, 2-methylpyrazine, cyclohexanone, and other lung cancer phospholipids.

In addition, in the above embodiments, the exhalation collecting device constitutes an exhalation pocket 193 inside the quantitative sheath 194, and has opening and closing means having one-way in the exhalation inlet pipe 191 and the exhalation outlet pipe 196. As a configuration using a unidirectional valve, it turns out that the technical idea of the present invention is not limited to this. That is, it can be configured without a quantitative envelope, and it is noted that the opening and closing means can also be configured to be opened and closed by an electronic signal.

In addition, in the above embodiments, the aerobic collecting device is configured as an example separately from the sensor electrode part, but it is revealed that the technical idea of the present invention is not limited thereto. That is, the aerobic collecting device and the sensor electrode part may be integrally configured.

In addition, in the above embodiments, it has been described as an example of detecting the amount of electrons moved by the lung cancer phosphorus substance, but it is revealed that the technical idea of the present invention is not limited thereto. In other words, the CV is measured using the potentiostat, the CA is measured, the CP is measured, or the SV is measured, or LSV is measured to detect lung cancer phospholipids and its amount can be measured. You can. For example, as shown in FIG. 28, a working electrode W is formed by conducting [TiO₂] and [Li + @ C60] [PF6-] on the FTO transparent electrode, and the counter electrode is a platinum electrode Pt. (CE), the reference electrode (RE) is composed of a silver chloride electrode (AgCl), mounted on a quartz glass test tube, diluted with a specific solvent, and then subjected to CV measurement to determine the presence and amount of lung cancer-causing substances. Can be measured.

29 is a graph showing a part of the CV curve in an enlarged scale, and shows the response according to the energy level design of a lung cancer-causing substance ((a) curve) and a substance not ((b) curve). (A) In the curve, when “a” is periodically switched between irradiation and excitation of light (excitation energy), excitation occurs on the anode-side moving inducing material due to the excitation energy of light, resulting in a large current (light irradiation). Cut off), and "b" indicates when no light has been irradiated (the "b" section is shown by inserting the state where the light source is turned off for convenience of explanation). At this time, it is possible to find out the presence and amount of lung cancer phosphorus substances by analyzing the difference in current value or graph characteristics. (B) The curve indicates that there is no change due to excitation energy (light irradiation) because it is not a lung cancer-causing substance.

In addition, as shown in FIG. 30, it is revealed that a dark phosphorous substance can be specified by using a quantum yield (IPCE) according to a wavelength of a light source supplied as excitation energy as a characteristic element.

1: Lung cancer phosphorus
110: detection unit 120: sensor electrode unit
121: anode 122: anode side transfer inducer
122a: positive electrode side 1 transfer inducing material 122b: positive electrode side 2 move inducing material
123: cathode-side moving inducing material 124: cathode-side moving inducing material
125: case 125a: opening
126: fan 127: exhalation induction pipe
130: excitation energy supply unit 131: light source
140: data storage unit 150: control unit
160: display unit 161: time display unit
162: hearing display unit 170: communication unit
171: wired communication unit 172: wireless communication unit
180: Power supply unit 190: Expiration device
191: exhalation inflow pipe 192: inflow opening and closing means
193: expiration pocket 194: quantitative envelope
195: Collection space 196: Expiratory flow pipe
197: Spill opening and closing means W: Working electrode
RE: Reference electrode CE: Counter electrode

Claims (37)

A sensor electrode unit in which an energy level of an oxidation-reduction potential is set so that electrons are transferred from a cathode to an anode through a lung cancer phosphorus material contained in exhalation;
A detection unit for detecting electron movement of the sensor electrode unit;
A display unit showing information on the detection of the lung cancer phosphorus substance;
A control unit connected between the sensor electrode unit, the detection unit, and the display unit; And,
It comprises a; power supply for supplying operating power to each of the components, including,
A lung cancer sensor using exhalation, characterized by detecting and displaying a lung cancer phosphorus substance from the exhalation flowing into the sensor electrode. A sensor electrode unit in which an energy level of an oxidation-reduction potential is set so that electrons are transferred from a cathode to an anode through a lung cancer phosphorus material contained in exhalation;
An excitation energy supply unit that supplies excitation energy of electrons to the sensor electrode unit;
A detection unit for detecting electron movement of the sensor electrode unit;
A display unit showing information on the detection of the lung cancer phosphorus substance;
A control unit connected between the sensor electrode unit, the excitation energy supply unit, the detection unit, and the display unit; And,
It comprises a; power supply for supplying operating power to each of the components, including,
A lung cancer sensor using exhalation, characterized by detecting and displaying a lung cancer phosphorus substance from the exhalation flowing into the sensor electrode. A sensor electrode unit in which an energy level of an oxidation-reduction potential is set so that electrons are transferred from a cathode to an anode through a lung cancer phosphorus material contained in exhalation;
An excitation energy supply unit that supplies excitation energy of electrons to the sensor electrode unit;
A detection unit for detecting electron movement of the sensor electrode unit;
A display unit showing information on the detection of the lung cancer phosphorus substance;
A data storage unit that stores information on the detection of the lung cancer phosphorus substance;
A control unit connected between the sensor electrode unit, an excitation energy supply unit, a detection unit, a display unit, and a data storage unit; And,
It comprises a; power supply for supplying operating power to each of the components, including,
A lung cancer sensor using exhalation, characterized by detecting and displaying a lung cancer phosphorus substance from the exhalation flowing into the sensor electrode. A sensor electrode unit in which an energy level of an oxidation-reduction potential is set so that electrons are transferred from a cathode to an anode through a lung cancer phosphorus material contained in exhalation;
An excitation energy supply unit that supplies excitation energy of electrons to the sensor electrode unit;
A detection unit for detecting electron movement of the sensor electrode unit;
A display unit showing information on the detection of the lung cancer phosphorus substance;
A data storage unit that stores information on the detection of the lung cancer phosphorus substance;
A communication unit for exchanging information on the detection of human lung cancer substance with an external device;
A control unit connected between the sensor electrode unit, an excitation energy supply unit, a detection unit, a display unit, a data storage unit, and a communication unit; And,
It comprises a; power supply for supplying operating power to each of the components, including,
A lung cancer sensor using exhalation, characterized by detecting and displaying a lung cancer phosphorus substance from the exhalation flowing into the sensor electrode. According to any one of claims 1 to 4, wherein the lung cancer is a toluene (Toluene), 2,6-diisopropyl phenol (2,6-Diisopropylphenol), 2-methylpyrazine (2-Methylpyrazine), Cyclohexanone (Cyclohexanone), 2-butanone, acetic acid, acetonitrile, lung cancer sensor using exhalation, characterized in that any one or more of. The lung cancer using exhalation according to any one of claims 1 to 4, wherein, when the lung cancer phosphorus substance is detected and displayed in exhalation, the amount of the lung cancer phosphorus substance is detected and the degree of cancer progression is determined and indicated. sensor. The exhalation according to any one of claims 1 to 4, wherein when the lung cancer phosphorus substance is detected and displayed in the exhalation, the ratio of two or more lung cancer phosphorus substances is calculated to determine and show the type of cancer. Used lung cancer sensor. According to any one of claims 1 to 4, wherein the sensor electrode unit,
The energy level of the oxidation-reduction potential is designed to transfer electrons from the cathode to the anode through the electrons donated from the lung cancer phosphorus material, and multiple mechanisms are configured to allow the movement of electrons to be detected. Lung cancer sensor using exhalation, characterized in that configured to be. The lung cancer sensor using exhalation according to any one of claims 1 to 4, wherein the cathode or anode of the sensor electrode part is formed of a transparent electrode. The lung cancer sensor using exhalation according to claim 9, wherein the transparent electrode is made of any one or more of FTO, ITO, AZO, GZO, and TCO. According to any one of claims 1 to 4, wherein the sensor electrode unit,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; And,
It comprises a positive electrode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material, including,
A lung cancer sensor using exhalation, characterized in that an energy level is set to transfer electrons from the cathode to the anode via the lung cancer phosphorus material when the waste cancer phosphorus material is introduced between the cathode and the anode. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation; And,
The anode is configured to have a redox potential lower than the energy level of the conduction band of the lung cancer phosphorus material.
When the waste cancer phosphor is introduced between the cathode and the anode, electrons in the valence band of the lung cancer phosphor are excited by the excitation energy supplied from the excitation energy supply unit, and electrons excited by the conduction band move to the anode. And, the lung cancer sensor using exhalation, characterized in that the energy level is set so that the process of electron transfer from the cathode to the positive hole formed in the valence band of the lung cancer substance. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; And,
The anode level is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. Containing, including;
When a waste cancer substance is introduced between the cathode and the anode, electrons in the valence band of the anode-side moving inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the conduction band of the anode-side moving inducing material Electrons excited by are moved to the positive electrode, electrons in the valence band of the lung cancer-causing material move to the positive holes formed in the valence band of the positive electrode-side transfer inducing material, and electrons from the negative electrode to the positive holes in the valence band of the lung cancer-causing material Lung cancer sensor using exhalation, characterized in that the energy level is set so that the process of moving. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material; And,
The energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. Induced material; including,
When a waste carcinogen is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side moving inducing material excite the conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side moving inducing material The electrons excited by the conduction band of the electrons move to the anode, and secondly, electrons in the valence band of the lung cancer phosphorus material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and excited by the conduction band of the lung cancer phosphorus material The excitation, characterized in that the energy level is set so that the electrons move to the positive holes formed in the valence band of the positive electrode-side transfer inducing material, and third, the electrons move from the cathode to the positive holes formed in the valence band of the lung cancer phosphor material Used lung cancer sensor. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have an oxidation-reduction potential lower than the energy level of the valence band of the lung cancer phosphorus material; And,
The energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band is higher than the energy level of the valence band of the lung cancer substance. Containing, including;
When a waste carcinogen is introduced between the cathode and the anode, first, electrons in the lung carcinogen are transferred to the anode, and second, by the excitation energy supplied from the excitation energy supply unit to the valence band of the cathode-inducing transfer inducer. The electrons excited by the conduction band are excited, and the electrons excited by the conduction of the cathode-side transfer inducing material move to the positive holes formed in the valence band of the lung cancer-causing material, and, third, the negative electrodes are positive holes formed in the valence band of the negative-side shift inducing material. Lung cancer sensor using exhalation, characterized in that the energy level is set so that the process of electron movement in the. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have an oxidation-reduction potential lower than the energy level of the conduction band of the lung cancer phosphorus material; And,
The energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band is higher than the energy level of the valence band of the lung cancer substance. Containing, including;
When a lung cancer phosphorus material is introduced between the cathode and the anode, first, electrons in the valence band of the lung cancer phosphorus material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and excited by the conduction band of the lung cancer phosphorus material Electrons move to the anode, and secondly, electrons in the valence band of the cathode-side moving inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and electrons excited by the conduction of the cathode-side moving inducing material A is used for exhalation, characterized in that the energy level is set such that the process moves electrons from the cathode to the positive holes in the valence band of the lung cancer phosphorus material. Lung cancer sensor. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material;
The anode level is configured such that the energy level of the redox potential of the valence band is lower than the energy level of the valence band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. Moving inducers; And,
The energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band is higher than the energy level of the valence band of the lung cancer substance. Containing, including;
When a waste carcinogen is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side moving inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side moving induction Electrons excited by the conduction band of the material move to the anode, and second, electrons in the valence band of the lung cancer-causing material move through the holes formed in the valence band of the anode-side moving inducing material, and third, supplied from the excitation energy supply unit The electrons in the valence band of the cathode-side moving inducing material are excited by conduction band by the excitation energy, and the electrons excited by the conduction band of the cathode-side moving inducing material move to the positive holes formed in the valence band of the lung cancer-causing material, and fourth , The positive electrode of the cathode-side transfer inducing material is a hole formed in the valence band, so that the process of electron transfer from the cathode is made. Lung cancer sensor using exhalation, characterized in that the ground level is set. According to any one of claims 2 to 4, wherein the sensor electrode portion,
A cathode configured to have a redox potential lower than the energy level of the valence band of the lung cancer phosphorus material contained in the exhalation;
An anode configured to have a redox potential higher than the energy level of the valence band of the lung cancer phosphorus material;
The energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the lung cancer phosphorus material, and the energy level of the redox potential of the conduction band is higher than the energy level of the redox potential of the anode. Inducers; And,
The energy level of the redox potential of the valence band is lower than the energy level of the redox potential of the cathode, and the energy level of the redox potential of the conduction band is higher than the energy level of the valence band of the lung cancer substance. Containing, including;
When a waste carcinogen is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side moving inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side moving induction Electrons excited by the conduction band of the material move to the anode, and secondly, electrons in the valence band of the lung cancer phosphorus material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and excited by the conduction of the lung cancer phosphorus material The transferred electrons move to the positive holes formed in the valence band of the anode-side moving inducing material, and third, the electrons in the valence band of the cathode-side moving inducing material excite as a conduction band by the excitation energy supplied from the excitation energy supply unit, and the Electrons excited by the conduction band of the cathode-side shift-inducing material are formed into holes in the valence band of the lung cancer-causing material. Moving, fourth, lung cancer sensor using exhalation, characterized in that the energy level is set so that the process of electron transfer from the cathode to the positive hole formed in the valence band of the cathode-side transfer inducer. According to any one of claims 2 to 4, In setting the energy level of the oxidation-reduction potential so that the electrons are transferred from the cathode to the anode via electrons donated from the lung cancer phosphorus material in the sensor electrode part, the In the case where a plurality of anode-side transfer-inducing substances that induce movement of the donated electrons from the lung cancer-causing substance to the anode,
The energy level of the conduction band of the first positive electrode-side mobile inducer that receives electrons from the lung cancer-causing material is set higher than the energy level of the valence band of the next positive electrode-side mobile inducer,
The energy level of the conduction band of the last anode-side transfer-inducing material that donates electrons to the anode is set higher than the energy level of the anode,
The energy level of the anode-side mobile inducing substance in the intermediate stage is set to be higher than the energy level of the valence band of the positive-electrode-moving substance in the next stage, and the energy level of the valence band is set in the previous stage. A lung cancer sensor using exhalation, characterized in that the anode-side mobile inducer is set lower than the energy level of the conduction band. According to any one of claims 2 to 4, In setting the energy level of the oxidation-reduction potential so that the electrons are transferred from the cathode to the anode via electrons donated from the lung cancer phosphorus material in the sensor electrode part, the In the case where a plurality of cathode-side moving inducing substances inducing the transfer of electrons donated from the cathode to the lung cancer-causing substance are formed,
The energy level of the conduction band of the first cathode-side mobile induction material receiving electrons from the cathode is set higher than the energy level of the valence band of the next negative-electrode mobile induction material,
The energy level of the conduction band of the last cathode-side transfer-inducing material that donates electrons with holes formed in the valence band of the lung cancer phosphorus material is set higher than the energy level of the valence band of the lung cancer phosphorus material,
The energy level of the cathode-side mobile inducing substance in the intermediate stage is set higher than the energy level of the valence band of the cathode-side mobile inducing substance in the next stage, and the energy level of the valence band in the previous stage is set. A lung cancer sensor using exhalation, characterized in that the cathode side of the mobile induction material is set lower than the energy level of the conduction band. According to any one of claims 2 to 4, In setting the energy level of the oxidation-reduction potential so that the electrons are transferred from the cathode to the anode via electrons donated from the lung cancer phosphorus material in the sensor electrode part, the Set the energy level using the anode-side transfer-inducing material that induces the transfer of electrons donated from the lung cancer-causing substance to the anode, or the cathode-side transfer-inducing substance that induces the transfer of electrons from the cathode to the lung cancer-causing substance. In the case, the positive electrode side transfer inducing material, or negative electrode side transfer inducing material,
A lung cancer sensor using exhalation, characterized in that it consists of at least one of fullerene, fullerene salt, ion-containing fullerene, pigment, or a complex of ion-containing fullerene and pigment. 22. The lung cancer sensor according to claim 21, wherein the fullerene is any one of C60, C70, C72, C78, C82, C90, C94, and C96. The lung cancer sensor using exhalation according to claim 21, wherein the ion contained in the ion-containing fullerene is any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium. 22. The method of claim 21, wherein the pigment is polythiophene such as poly-3-hexyl thiophene (P3HT), polyp-phenylene, polyp-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, Lung cancer sensor using exhalation, characterized in that it is at least one of polymer polymers such as MDMO-PPV, MEH-PPV, or derivatives thereof. According to any one of claims 2 to 4, In setting the energy level of the oxidation-reduction potential so that the electrons are transferred from the cathode to the anode via electrons donated from the lung cancer phosphorus material in the sensor electrode part, the Set the energy level using the anode-side transfer-inducing material that induces the transfer of electrons donated from the lung cancer-causing substance to the anode, or the cathode-side transfer-inducing substance that induces the transfer of electrons from the cathode to the lung cancer-causing substance. In the case, the positive electrode side transfer inducing material, or negative electrode side transfer inducing material,
A lung cancer sensor using exhalation, characterized in that it is included in the anode or the cathode using electrophoresis. According to any one of claims 2 to 4, The excitation energy supply unit, an optical energy supply unit for supplying light energy equal to or greater than the band gap energy between the valence band and the conduction band, or an electromagnetic wave energy supply unit for supplying electromagnetic energy, or A lung cancer sensor using exhalation, characterized in that it consists of any one or more of the thermal energy supply unit for supplying thermal energy. The lung cancer sensor using exhalation according to claim 26, wherein the light energy supply unit supplies one or more light energy having different wavelengths and brightness. 27. The method of claim 26, wherein the light source of the light energy supply unit, LED light sources having different wavelengths, or laser light sources having different wavelengths, or halogen lamps, or mercury lamps, or xenon lamps. Lung cancer sensor using exhalation. The lung cancer sensor using exhalation according to claim 26, wherein the electromagnetic energy supply unit supplies one or more electromagnetic energy having different wavelengths and intensities. The lung cancer sensor using exhalation according to claim 26, wherein the thermal energy supply unit supplies one or more thermal energy having different temperatures. The lung cancer sensor using exhalation according to any one of claims 1 to 4, further comprising: an aerobic collection device for collecting exhalation from a subject. The method of claim 31, wherein the aerobic capture device,
An exhalation pocket where exhalation is collected;
An exhalation inlet pipe provided on one side of the exhalation pocket to allow a subject to bite into the mouth and blow exhalation; And,
A lung cancer sensor using exhalation, characterized in that it comprises a; exhalation tube provided on the other side of the exhalation pocket to supply the exhaled air captured by the sensor electrode portion. The method of claim 31, wherein the aerobic capture device,
An exhalation pocket where exhalation is collected;
The exhalation pocket is provided therein, a quantitative envelope that limits the amount of exhalation collected in the exhalation pocket;
It is provided on one side of the exhalation pocket, the exhalation inlet tube that the subject bites into the mouth and blows exhalation; And,
It is provided on the other side of the exhalation pocket, a lung cancer sensor using an exhalation, characterized in that comprises a; exhalation tube for supplying the collected exhalation to the sensor electrode. The method of claim 32, wherein the aerobic capture device,
A lung cancer sensor using exhalation, further comprising an inflow opening / closing means, which is a unidirectional opening / closing means that is opened only in the direction of the internal collection portion of the exhalation pocket in the exhalation inlet pipe. delete According to any one of claims 1 to 4, The detection unit, Cyclic Voltammetry (CV) or Chrono Amperometry (CA), or CP (Chorono Potentiommetry), or SV (Stripping Voltammetry) of the lung cancer phospholipid, or Lung cancer sensor using exhalation, characterized by detecting the presence and amount of lung cancer phosphorus by detecting any one or more of LSV (Linear Sweep Voltammetry). According to any one of claims 1 to 4, wherein the detection unit detects the quantum yield according to the wavelength of the light source supplied by the excitation energy to detect the presence and amount of lung cancer phosphorus material using exhalation. Lung cancer sensor.

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