KR102231421B1 - molecule sensor - Google Patents

Abstract

The present invention relates to a molecular sensor of a new concept capable of detecting a substance to be detected on a molecular basis. In particular, in consideration of the energy level of the oxidation-reduction potential of the substance to be detected, a cathode, an anode, an anode side movement inducer, and a cathode After designing the energy level of the lateral movement inducing material, supplying excitation energy, electrons are allowed to move from the cathode to the anode through electrons donated by the detection target material, and the detection target by detecting the movement of the electrons. It has the effect of enabling precise detection of the presence or absence of substances and molecular units.
In addition, ion-containing fullerenes, fullerene salts, and fullerenes. By designing the energy level using a dye or the like, there is an effect of widening the detection target range and improving the measurement sensitivity.
The present invention provides a ppt-level precise detection technology to solve the detection problems that could not be solved with conventional technologies in the field of ultra-precise diagnostic medicine, ultra-precise sensing, ultra-precise control, and bio, space science. It has an effect of configuring a cancer diagnosis sensor, a tuberculosis diagnosis sensor, a bad breath diagnosis sensor, a stress sensor, a poison gas detection sensor, a pesticide detection sensor, an explosive detection sensor, and the like.

Description

Molecule sensor

The present invention relates to a molecular sensor that detects the presence, type and amount of a substance to be detected on a molecular basis. In particular, the present invention relates to a molecular sensor that is proportional to the number of molecules of a substance to be detected (hereinafter, referred to as "substance to be detected"). By designing the energy level of the redox potential of each of the negative electrode and the positive electrode in consideration of the energy level of the redox potential of the substance to be detected so that a number of electrons can move from the negative electrode to the positive electrode, the detection target substance can be accurately detected in molecular units. I made it so.

In addition, a material that relays the movement of electrons from the cathode to the anode according to the type of the detection target material to be detected (hereinafter, a material that relays the movement of electrons from the cathode to the anode is referred to as a "migration inducing material"). And, by further including an excitation energy supply unit that supplies excitation energy that excites electrons in the valence band to the conduction band, more precise detection can be made.

In addition, the energy level of the redox potential is lowered by using dyes, fullerenes, fullerene salts, or fullerenes containing ions (hereinafter referred to as "ion containing fullerenes") as migration inducing substances. By increasing the quantum yield, the range of substances that can be detected is widened and the measurement sensitivity is improved.

Efforts to detect whether a specific substance is present has been accelerated further with the development of industrial technology, and many types of sensors using various principles have been developed in various industrial groups. These various sensors have quickly replaced the five senses of humans across all industries such as electricity, electronics, machinery, chemistry, physics, bio, and medicine, and as information and communication technology and IoT technology converge, the scope of use becomes wider and more precise. have.

As the technology further develops, the development of ultra-precise sensors capable of detecting trace amounts of substances has been continuously made and is being used in the field of ultra-precision diagnostic medicine, the field of ultra-precision sensing, the field of ultra-precision control, and the field of bio and space science.

1) Cantilever type precision sensor that detects the substance to be detected by detecting the mechanical distortion caused by adsorption of the substance to be detected,

2) A semiconductor sensor type precision sensor that detects the material to be detected by detecting the change in resistance due to the adsorption of the material to be detected,

3) Precision sensor using asymmetric field ion movement analysis method that detects the substance to be detected by passing the substance to be detected inside the fluctuating electric field so that only molecules with a specific mass cross-sectional area reach the detector,

4) Precision sensor using a gene sensing method that detects the substance to be detected using the receptor of a genetically modified mouse,

5) A sensor using an antigen-antibody reaction is an example of such an ultra-precision sensor.

However, in ~ ppb (. Parts per billion 1/10 -9) conventional techniques is that the detection accuracy ^{ppm (parts per million, 1/10 -6} ) level as described above, ppt (parts per trillion, 1/10 - ¹² ) There was a problem in that it was difficult to measure precisely up to the level and ultra-precise measurement in molecular units.

An object of the present invention is to solve the conventional problems as described above, in particular, a new concept that enables precise detection of more than the ppt level by detecting a substance to be detected in molecular units using the energy level of the redox potential. It is to provide a "molecular sensor".

In addition, it is to provide a "molecular sensor" capable of real-time detection by detecting a current through electrons donated from a detection target material.

In addition, by detecting the detection target material using movement inducing materials (positive side movement inducing material, cathode side movement inducing material) having energy levels of various redox potentials, the detection target is widened and more precise detection is made. will be.

The present invention is a molecular sensor capable of accurately detecting a substance to be detected on a molecular basis by using the energy level of the redox potential. In particular, by analyzing the energy level of the redox potential of the substance to be detected, the substance to be detected It is characterized by designing and configuring the energy levels of the redox potentials of the cathode material and the anode material so that electrons transfer from the cathode to the anode via electrons donated from the detection target material when the material is introduced.

In addition, the energy level of the redox potential is designed using one or more migration inducing materials that relay electrons from the cathode to the anode, and conduction bands in the Highest Occupied Molecular Orbital (HOMO) of the Valence Band. Band)'s LUMO (Lowest Unoccupied Molecular Orbital) provides excitation energy (light energy, thermal energy, etc.) so that electrons can be excited to control the movement of electrons, so that more accurate detection can be made. .

In addition, it is characterized in that the detection range is widened and the measurement sensitivity is improved by constituting a migration-inducing substance with at least one of fullerene, fullerene salt, ion-containing fullerene, dye, or a complex of ion-containing fullerene and dye.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, C96, and the ions contained in the ion-containing fullerene are lithium, sodium, potassium, cesium, magnesium, calcium, Or strontium, wherein the dye is polythiophene such as poly-3-hexylthiophene (P3HT), polyp-phenylene, polyp-phenylene vinylene, polyaniline, polypyrrole, PEDOT , P3OT, POPT, MDMO-PPV, MEH-PPV, and other polymers or derivatives thereof.

In particular, the "molecular sensor" of the present invention detects a substance to be detected using an energy level of an oxidation-reduction potential, thereby enabling precise detection of a molecular unit with an accuracy of a ppt level or higher.

In addition, by designing an energy level using a movement inducing substance, the detection range is broadened, selectivity is improved, and accuracy is improved.

In addition, there is an effect of further expanding the detection range and accuracy by designing the energy level of the redox potential using ion-containing fullerenes and pigments, etc., which have a very low redox potential and a high quantum yield.

The present invention provides a precise detection technology higher than the ppt level to solve the detection problems that could not be solved with conventional technologies in the field of ultra-precise diagnostic medicine, ultra-precise sensing, ultra-precise control, and bio, space science, and a leap forward in the field. It has the effect of traction.

For example, it can be configured to diagnose cancer early by detecting cancer-causing substances (substances caused by cancer) present in trace amounts in breath, urine, blood and saliva, and tuberculosis-causing substances (tuberculosis-causing substances). It can be configured so that tuberculosis can be diagnosed early by detecting the substance that is caused by bad breath, and it can be configured so that the cause of bad breath can be identified by detecting substances that cause bad breath (materials caused by bad breath). There is an effect that can detect the level of stress by detecting (substances caused by stress). In addition, it can be configured to detect a very small amount of lethal poison gas such as sarin gas and dioxin, and to perform a preliminary warning, and it can be configured to detect a very small amount of pesticide by detecting a pesticide component, and an explosive substance can be detected by detecting a bomb component. In addition to being configured to detect, there is an effect of being able to configure various precision sensors in various fields.

1 is a view showing the energy level design of the redox potential of the present invention "molecular sensor",
2 is a view showing the energy level design of another redox potential of the "molecular sensor" of the present invention;
3 is a diagram showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
4 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
5 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
6 is a view showing another energy level design of the redox potential of the present invention "molecular sensor",
7 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
8 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
9 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
10 is a diagram showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
11 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
12 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
13 is a view showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
14 is a diagram showing another energy level design of the redox potential of the "molecular sensor" of the present invention;
15 is a block diagram showing the system configuration of the present invention;
16 is a view showing the configuration of the sensor electrode unit of the present invention,
17 is a diagram showing the design of the energy level of the redox potential according to an embodiment of the present invention;
18 is a view showing the configuration of a sensor electrode unit according to an embodiment of the present invention;
19 is a view showing another configuration of a sensor electrode unit according to an embodiment of the present invention;
20A is a conceptual diagram showing an ion-containing fullerene,
20B is a conceptual diagram showing the configuration of a polymer in which an ion-containing fullerene and a dye are bound;
20C is a conceptual diagram showing an excited state of electrons by light energy,
21 is a conceptual diagram showing electrophoresis of a fullerene-pigmented polymer on a positive electrode,
22 is a diagram showing the energy level of an electron;
23 is a diagram conceptually showing a circuit configuration of a potentiostat;
24 is a diagram showing an example of a configuration of a measurement electrode;
25 is a graph showing an enlargement of a section of a CV graph;
26 is a graph showing an example of a quantum yield according to the wavelength.

The technical idea of the present invention will be described in detail with reference to specific configurations and embodiments according to the technical idea.

In describing the present invention by way of example, the same or similar names and symbols are used for components having the same or similar configuration and function, and additional description that may be redundant or limitedly interpret the meaning of the invention. May be omitted in describing embodiments of the present invention.

Prior to the detailed description, the concept of the invention in light of the environment in which the singular/plural is not clearly distinguished in the use of the Korean language and the environment in which the terms are used in the related field, even though it is described in a singular expression in this specification. It is used as a meaning that includes multiple expressions unless it is contradictory in interpretation and does not mean clearly differently. In addition,'comprises','have','includes','comprises', and the like described or may be described in the present specification indicate the presence or addition of one or more other features or elements or combinations thereof. It should be understood that it is not excluded in advance.
In one aspect, the oxidation-reduction potential described in the present invention refers to an electrical potential required to transfer electrons from a certain compound or element to another element or compound, and the energy level of the redox potential is a certain substance. It refers to the intrinsic energy level of the redox potential of.
Preferably, the molecular sensor of the present invention is designed based on the energy level of the redox potential of the substance to be detected in a vacuum state, and the energy level of the redox potential may be abbreviated as an energy level.
For example, the energy level of the redox potential of the valence band of toluene in a vacuum (hereinafter, it can be abbreviated as “the energy level of the valence band”) is -6.55 eV, and the energy level of the redox potential of the conduction band ( Hereinafter, it can be abbreviated as “the energy level of the electron band”) is -0.18 eV. In the case of platinum, the energy level of the valence band is -5.93 eV, and the energy level of the conduction band is -5.12 eV.
In another aspect, the present invention is a molecular sensor that sets the energy level of the redox potential in a vacuum state, and preferably, a cathode having an energy potential of the redox potential (hereinafter, It is based on an anode having an energy potential of the redox potential (hereinafter, it may be abbreviated as the energy potential of the anode).

<Configuration 1>

Configuration 1 according to the technical idea of the "molecular sensor" of the present invention, as shown in FIG. 1, is based on the energy level of the redox potential of the material to be detected in a vacuum state.
A cathode configured to have an energy level of a redox potential higher than that of the valence band of the material to be detected in a vacuum state; And, an anode configured to have an energy level of an oxidation-reduction potential lower than the energy level of the valence band of the material to be detected; when the material to be detected flows between the cathode and the anode, the material to be detected is used as a medium. Thus, the energy level is set so that electrons can be transferred from the cathode to the anode.

In the configuration 1 of the present invention configured as described above, the energy level of the cathode is designed to be higher than that of the material to be detected, and the energy level of the anode is designed to be lower than that of the material to be detected. This is to allow the movement of electrons to the anode.

The relationship between the energy level c of the valence band of the positive electrode, the energy level e of the valence band of the substance to be detected, and the energy level a of the valence band of the negative electrode is as follows.

Energy level of configuration 1: c<e, e<a

In the configuration 1 of the present invention, when a detection target material having an energy level of a redox potential between the energy level value of the cathode and the energy level value of the anode is introduced, electrons in the valence band of the detection target material are It moves to the anode with the energy level of the low redox potential and moves electrons from the cathode to the positive holes of the valence band of the material to be detected due to the electrons moved to the anode. As long as the material to be detected is present, the material to be detected The number of electrons proportional to is constantly moving.

At this time, it is possible to determine whether or not the detection target material exists by detecting the movement of electrons (whether or not the current flows), and accurately determine the amount of the introduced detection target material by detecting the movement degree (current amount) of electrons. have.

Since the movement of electrons is proportional to the number of molecules of the substance to be detected, it is possible to perform very precise detection on a molecular basis by detecting the movement (current amount) of the moving electrons.

The selectivity for the detection target material increases as the energy level difference between the cathode and the anode is finer.

The technique according to configuration 1 of the present invention is preferably used when it is desired to detect a substance having radicals in a natural state, such as nitrogen oxide (NOx) or hydrogen peroxide.

<Configuration 2>

Configuration 2 according to the technical idea of the "molecular sensor" of the present invention is to have an energy level of a redox potential higher than the energy level of the valence band of the material to be detected based on a vacuum state, as shown in FIG. Configured cathode; An anode configured to have an energy level of an oxidation-reduction potential lower than that of the conduction band of the material to be detected; And an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material are excited in a conduction band, and when the detection target material flows between the cathode and the anode, the excitation energy Electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the supply unit, the electrons excited with the conduction band move to the anode, and electrons from the cathode through the positive holes created in the valence band of the detection target material It is a feature of its technical construction that the energy level of the redox potential is set so that the process of moving is carried out.

Energy level of configuration 2: c>e, e<a

In the configuration 2 of the present invention configured as described above, excitation energy (e.g., light) that is greater than the band gap energy of the detection target material and the conduction band is supplied to the detection target material to the valence band of the detection target material. The electrons in the conduction band are excited, and the electrons excited in this conduction band are This is to move to the anode with the energy level of the redox potential lower than the energy level. In addition, electrons are moved from the cathode to the positive holes in the valence band of the detection target material to allow current to flow. As long as excitation energy is supplied, the above process is repeated to generate a current proportional to the number of molecules of the detection target material. I let it flow.

In the configuration 2 of the present invention, when the energy level of the positive electrode is higher than the energy level of the valence band of the detection target material and electrons in the valence band of the detection target material cannot move to the positive electrode, the electrons in the valence band of the detection target material The excited electrons can move to the anode by using the energy level of the redox potential of the excited electrons by exciting the conduction band.

This is described again as follows.

As is well known, as shown in Fig. 22, a band full of electrons is referred to as a valence band, and the highest occupied orbit is referred to as HOMO. In addition, the band in which the electrons are empty is called the conduction band, the lowest orbit is called LUMO, and the energy between homo and lumo is called bandgap energy (Eg), and the energy above this bandgap energy is called If supplied, electrons in the valence band can be excited by the conduction band.

In the configuration 2 of the present invention, as shown in FIG. 2, the energy level of the redox potential is adjusted by supplying energy equal to or greater than the bandgap energy through the excitation energy supply unit to excite electrons in the valence band of the detection target material to the conduction band. By raising it, electrons move to the anode.

The excitation energy supply unit is characterized in that it is composed of at least one of a light energy supply unit, an electromagnetic wave energy supply unit, or a thermal energy supply unit that supplies energy equal to or greater than the band gap energy between the valence band and the conduction band.

The excitation energy supply unit constitutes excitation energy using light energy, electromagnetic wave energy, or thermal energy, and in some cases, two or more energy sources may be used together to construct excitation energy. For example, it may be configured to supply a certain amount of excitation energy with light energy and a certain amount of excitation energy with thermal energy. This configuration is intended to be used when one energy source cannot supply the desired amount of excitation energy.

In the description, the concept of "electromagnetic wave" includes both heat and light, but they are used separately for convenience of description.

The light irradiated by the optical energy supply unit is characterized in that it is composed of one or more lights having different wavelengths and brightnesses.

The light source irradiated by the light energy supply unit is characterized in that it is composed of at least one of an LED light source having a different wavelength, a laser light source having a different wavelength, a halogen lamp, a mercury lamp, or a xenon lamp.

Such an optical energy supply unit is for supplying different band gap energy by designing the amount of excitation energy by wavelength or brightness.

For example, when a plurality of anode-side movement inducing materials or cathode-side movement inducing materials are used, and the band gap energy of the used movement inducing material is different, and it is necessary to supply each band gap energy separately, This can be achieved by adjusting the wavelength or brightness of the supplied light.

In this case, it goes without saying that band gap energy can be supplied to all the movement inducing materials by using one light separately from the above. That is, it can be configured to supply excitation energy to a plurality of movement inducing materials using one light source that supplies energy equal to or greater than the largest bandgap energy.

Since the configuration and operation of the driving device for driving the different light sources is as well known, a detailed description thereof will be omitted.

The electromagnetic wave supplied from the electromagnetic wave energy supply unit is characterized in that it is composed of one or more electromagnetic waves having different wavelengths and intensities.

The electromagnetic wave energy supply unit is for supplying different band gap energy by designing the amount of excitation energy by wavelength or intensity. For example, electromagnetic waves such as 1.0 GHz, 1.2 GHz, and 2 GHz may be used.

Since the configuration and operation of the electromagnetic wave generating device for supplying different electromagnetic waves is as well known, a detailed description thereof will be omitted.

The heat irradiated by the thermal energy supply unit is characterized in that it is composed of one or more heat having different temperatures and strengths.

The thermal energy supply unit is for supplying different band gap energy by designing the amount of excitation energy by temperature and intensity. For example, it can be configured to supply heat such as 1,000° C. heat and 1,500° C. heat.

Since the configuration and operation of the heat generating device for generating heat is as well known, a detailed description thereof will be omitted.

In this configuration 2, the anode or cathode is preferably made of a transparent electrode. These transparent electrodes are intended to allow the light irradiated from the excitation energy supply unit to be transmitted through and irradiated to the material to be detected. TCO (Transparent conducting oxide), FTO (F-doped [SnO₂]: fluorine-doped tin oxide), Transparent electrodes such as ITO (Indium tin oxide), AZO (Al-doped ZnO: aluminum-doped zinc oxide), and GZO (Ga-doped ZnO: brown-doped zinc oxide) may be used.

<Configuration 3>

Configuration 3 according to the technical idea of the "molecular sensor" of the present invention is a cathode configured to have an energy level of a redox potential higher than the energy level of the valence band of the material to be detected in a vacuum, as shown in FIG. 3 ; An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected; An anode-side movement inducer configured to have an energy level of a valence band lower than an energy level of the valence band of the detection target material and an energy level of a redox potential higher than that of the anode; And, an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the anode-side movement inducing material can be excited with a conduction band; and, when a detection target material is introduced between the cathode and the anode, the Excitation energy supplied from the excitation energy supply unit excites the electrons in the valence band of the anode-side movement inducing material into a conduction band, and the excited electrons move to the anode through the conduction band of the anode-side movement induction material. As a feature of its technical construction, the energy level is set so that electrons of the detection target material move to the holes created in the valence band of the inducer, and the electrons move from the cathode to the holes created in the valence band of the detection target material. do.

Energy level of configuration 3: c>e>g, e<a

Configuration 3 of the present invention configured as described above is characterized in that an electron movement path is designed by further configuring an anode-side movement inducing material between the detection target material and the anode.

In other words, an anode-side migration inducing material having an energy level of an oxidation-reduction potential lower than that of the valence band of the detection target material is further configured on the anode side to design an electron movement path through electrons donated from the detection target material. I did it.

The anode-side movement-inducing material or the cathode-side movement-inducing material is characterized in that it is composed of at least one of fullerene, fullerene salt, ion-containing fullerene, dye, or polymer of ion-containing fullerene and dye.

The fullerene is characterized in that any one of C60, C70, C72, C78, C82, C90, C94, and C96.

The ions contained in the fullerene are lithium, sodium, potassium, cesium, magnesium, calcium, or strontium.

The dye is polythiophene such as poly-3-hexylthiophene (P3HT), polyp-phenylene, polyp-phenylene vinylene, polyaniline, polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV It is characterized in that it is at least one of a high-molecular polymer or a derivative thereof, such as.

FIG. 20A shows the C60 fullerene contains ions, FIG. 20B shows the combination of the ion-containing fullerene and the dye, and 20C is a conceptual diagram showing the excitation of electrons by light energy.

Lithium-containing fullerene has the advantage of being able to widen the range of the detection target material to be detected because the energy level of the redox potential of the valence band is very low.

In addition, lithium-containing fullerene has an advantage of improving measurement sensitivity due to high quantum yield (IPCE: Incident Photon to Current Efficiency).

The quantum yield refers to the ratio of the number of molecules actually causing a chemical change in the photochemical reaction and the number of absorbed photons.

The positive electrode-side movement inducing material or the negative electrode-side movement inducing material is included in the positive electrode or the negative electrode using electrophoresis.

Fig. 21 is a block diagram showing the electrophoresis of a fullerene-pigmented polymer 122a on an anode 121a.

As the anode-side transfer-inducing material or the cathode-side transfer-inducing material, materials having energy levels of various redox potentials, including [TiO₂] and [SnO₂], can be used. Can design.

<Configuration 4>

Configuration 4 according to the technical idea of the "molecular sensor" of the present invention, as shown in FIG. 4, is based on the energy level of the redox potential of the material to be detected in a vacuum state. A cathode configured to have an energy level of a redox potential higher than that of the valence band; An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected; An anode-side transfer inducer configured such that the energy level of the redox potential of the valence band is lower than the energy level of the conduction band of the material to be detected, and the energy level of the conduction band is higher than the energy level of the anode; And, excitation energy for supplying excitation energy so that electrons in the valence band of the anode-side movement inducer can be excited with a conduction band, and excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band. Consisting of including an energy supply unit; when the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side movement inducing material are transferred to the conduction band by the excitation energy supplied from the excitation energy supply unit. Here, the electrons excited by the conduction band of the anode-side movement inducing material move to the anode, and second, the electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, Energy so that the electrons excited in the conduction band of the detection target material move to the positive holes created in the valence band of the positive-side movement inducing material, and third, the electrons move from the cathode to the positive holes created in the valence band of the detection target material. It is a characteristic of its technical composition that the level is set.

Energy levels of configuration 4: c>g>e, e<a

In the configuration 4 of the present invention configured as described above, in designing the electron movement path according to the inflow of the detection target material, the electrons in the valence band of the detection target material and the anode-side movement inducing material are excited to form a molecular sensor. There are features.

<Configuration 5>

Configuration 5 according to the technical idea of the "molecular sensor" of the present invention, as shown in Fig. 5, is based on the energy level of the oxidation-reduction potential of the material to be detected in a vacuum state. A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band; An anode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected; A cathode-side movement inducing material configured to have an energy level of a valence band lower than that of the cathode, and an energy level of a conduction band having an energy level of an oxidation-reduction level higher than that of the valence band of the material to be detected; And, an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the cathode-side movement inducing material can be excited with a conduction band; and, when a detection target material is introduced between the cathode and the anode, first , Electrons in the detection target material move to the anode, and second, electrons in the valence band of the cathode-side transfer-inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the cathode-side transfer-inducing material The energy of the redox potential so that the electrons excited by the conduction band of are moved to the positive holes created in the valence band of the material to be detected, and third, the positive holes created in the valence band of the cathode-side movement inducing material move the electrons from the cathode. It is a characteristic of its technical composition that the level is set.

Energy level of composition 5: c<e, e>a>i

Configuration 5 of the present invention configured as described above is characterized in that, when the energy level of the oxidation-reduction potential of the detection target material is higher than that of the cathode, electrons can be smoothly transferred by the cathode-side movement inducing material.

<Configuration 6>

Configuration 6 according to the technical idea of the "molecular sensor" of the present invention is based on the energy level of the redox potential of the detection target material in a vacuum state, as shown in FIG. A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band; An anode configured to have an energy level of an oxidation-reduction potential lower than that of the conduction band of the material to be detected; A cathode-side movement inducing material configured to have an energy level of a valence band lower than that of the cathode, and an energy level of a conduction band having an energy level of an oxidation-reduction level higher than that of the valence band of the material to be detected; And, excitation that supplies excitation energy so that electrons in the valence band of the cathode-side movement inducing material can be excited with a conduction band, and excitation energy is supplied so that electrons in the valence band of the detection target material can be excited with a conduction band. An energy supply unit; when the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, Electrons excited by the conduction band of the detection target material move to the anode, and second, electrons in the valence band of the cathode-side movement inducing material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and the cathode side Oxidation-reduction so that the electrons excited by the conduction band of the movement inducing material move to the positive holes created in the valence band of the material to be detected, and third, the positive holes formed in the valence band of the cathode-side movement inducing material, make the process of moving electrons from the cathode. It is characterized by its technical construction that the energy level of the potential is set.

Energy level of composition 6: c>e, e>a>i

In the configuration 6 of the present invention configured as described above, in designing the electron movement path according to the inflow of the detection target material, the electrons in the valence band of the detection target material and the cathode-side movement inducing material are excited to form a molecular sensor. There are features.

<Configuration 7>

Configuration 7 according to the technical idea of the "molecular sensor" of the present invention is based on the energy level of the oxidation-reduction potential of the substance to be detected in a vacuum state. As shown in FIG. 7, the valence band of the substance to be detected is A cathode configured to have an energy level of an oxidation-reduction potential lower than that of An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected; An anode-side movement inducer configured to have an energy level of a valence band lower than an energy level of the valence band of the detection target material and an energy level of a redox potential higher than that of the anode; A cathode-side movement inducer configured to have an energy level of a valence band lower than that of the cathode, and a conduction band having an energy level of a redox potential higher than that of the valence band of the detection target material; And, supplying excitation energy so that electrons in the valence band of the anode-side transfer inducer can be excited with a conduction band, and supply excitation energy so that electrons in the valence band of the cathode-side transfer inducer can be excited with a conduction band. When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side movement inducing material are converted by excitation energy supplied from the excitation energy supply unit. Excited by a conduction band, electrons excited by the conduction band of the anode-side movement inducing material move to the anode, second, electrons of the detection target material move to the holes created in the valence band of the anode-side movement inducing material, and third, the The electrons in the valence band of the cathode-side movement inducer are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and electrons excited by the conduction band of the cathode-side movement induction material are generated in the valence band of the detection target material. It is characterized in its technical configuration that the energy level of the redox potential is set so that the positive hole moves to the positive hole, and fourthly, the positive hole formed in the valence band of the cathode-side movement inducing material causes the electrons to move from the negative electrode.

Energy level of composition 7: c>e>g, e>a>i

Configuration 7 of the present invention configured as described above is characterized in constructing a molecular sensor by designing an electron movement path according to the inflow of the detection target material using the anode-side movement-inducing material and the cathode-side movement-inducing material.

<Configuration 8>

Configuration 8 according to the technical idea of the "molecular sensor" of the present invention is based on the energy level of the oxidation-reduction potential of the substance to be detected in a vacuum state. As shown in FIG. 8, the home appliance of the substance to be detected is A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the magnetic zone; An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected; An anode-side movement inducer configured to have an energy level of a valence band lower than an energy level of a conduction band of the detection target material, and an energy level of a redox potential higher than that of the anode; A cathode-side movement inducer configured to have an energy level of a valence band lower than that of the cathode, and a conduction band having an energy level of a redox potential higher than that of the valence band of the detection target material; And, supplying excitation energy so that electrons in the valence band of the anode-side transfer inducer can be excited with a conduction band, and supply excitation energy so that electrons in the valence band of the cathode-side transfer inducer can be excited with a conduction band. And an excitation energy supply unit for supplying excitation energy so that electrons in the valence band of the detection target material can be excited with a conduction band, and when the detection target material is introduced between the cathode and the anode, first, the The electrons in the valence band of the anode-side transfer inducer are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and the excited electrons move to the anode by the conduction band of the anode-side transfer-inducing material. The electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the energy supply unit, and the electrons excited in the conduction band of the detection target material move to the positive holes created in the valence band of the anode-side movement inducing material. , Third, electrons in the valence band of the cathode-side movement inducer are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and the electrons excited by the conduction band of the cathode-side movement induction material are It is characterized in its technical configuration that the energy level of the redox potential is set so that the process of moving electrons from the cathode to the positive holes created in the valence band and fourth, the positive holes created in the valence band of the cathode-side movement inducer. .

Energy levels of composition 8: c>g>e, e>a>i

In the configuration 8 of the present invention configured as described above, in designing an electron movement path according to the inflow of the detection target material using the anode-side movement inducing material and the cathode-side movement inducing material, the anode-side movement-inducing material and the cathode-side movement-inducing material And excitation of a substance to be detected to constitute a molecular sensor.

<Other components>

In the above configurations, the anode-side movement inducing material for inducing the movement of electrons donated from the detection target material to the anode is characterized in that it is composed of one or more.

In the above configurations, when a plurality of anode-side movement inducing materials are used, as shown in Figs. 9 to 10 and 13 to 14, the first anode side movement induction that receives electrons from the detection target material. The energy level of the conduction band of the material is set higher than the energy level of the valence band of the next anode-side transfer inducer, and the energy level of the conduction band of the last anode-side transfer inducer that donates electrons to the anode is the energy level of the anode. Set higher, and the energy level of the redox potential of the anode-side transfer inducers in the intermediate step is set higher than the energy level of the valence band of the anode-side transfer-inducing material in the next stage, It is characterized in that the energy level of the valence band is set lower than the energy level of the conduction band of the anode-side transfer inducer in the previous stage.

This configuration enables detection of the detection target material by using a plurality of anode-side movement inducing materials, and enables more accurate design of the energy level of the redox potential for the detection target material.

In the above configurations, the cathode side movement inducing material for inducing the movement of electrons donated from the cathode to the detection target material is characterized in that it is composed of one or more.

In the above configuration, when a plurality of cathode-side transfer-inducing materials are formed, the energy level of the conduction band of the first cathode-side transfer-inducing material that receives electrons from the cathode is, as shown in Figs. The energy level of the conduction band of the last cathode-side transfer-inducing material that is set higher than the energy level of the valence band of the next cathode-side transfer-inducing material and donates electrons to the positive holes created in the valence band of the detection-target material is It is set higher than the energy level of the valence band, and the energy level of the redox potential of the cathode-side transfer inducers in the intermediate stage is the energy level of the conduction band and the energy level of the valence band of the cathode-side transfer-inducers in the next stage. It is characterized in that it is set higher and the energy level of the valence band is set lower than the energy level of the conduction band of the cathode-side movement inducing material in the previous stage.

This configuration enables detection of the detection target material by using a plurality of cathode-side movement inducing materials, and enables more accurate design of the energy level of the redox potential for the detection target material.

In the above configuration, as shown in Fig. 15, the detection unit 110 for detecting the flow of electrons according to the detection target material: characterized in that it is configured to further include.

The detection unit 110 detects the flow of electrons moving from the cathode to the anode, and calculates the amount as well as whether or not the detection target material is present. That is, by detecting the current and voltage between the positive electrode and the negative electrode, whether or not the detection target material flows and the amount of flow is detected.

The detection unit detects any one or more of CV (Cyclic Voltammetry), CA (Chrono Amperometry), CP (Chorono Potentiommetry), SV (Stripping Voltammetry), or LSV (Linear Sweep Voltammetry) of the target substance to be detected. It is characterized by detecting the presence and amount of a substance.

In other words, it is characterized by detecting the presence and amount of the detection target substance by measuring CV, or CA, or CP, or SV, or LSV of the detection target substance using a potentiostat. do.

Fig. 23 is a circuit diagram showing a simplified configuration of a potentiostat, detecting a substance to be detected through a working electrode (W), a reference electrode (RE), and a counter electrode (CE) can do. That is, after constructing the working electrode (W) using a movement inducing material (positive movement inducing material, negative movement inducing material), CV, CA, CP, SV, LSV, etc. are obtained through the three-electrode method or the two-electrode method, By analyzing this, the presence and amount of the substance to be detected can be accurately measured.

The configuration and operation principle of the potentiostat used in the field of electrochemistry and the three-electrode method, the two-electrode method, CV, CA, CP, SV, LSV, etc. are as well known, and thus detailed description thereof will be omitted.

The detection unit is characterized in that it detects the presence and amount of a substance to be detected by detecting an Incident Photon to Current Efficiency (IPCE) according to a wavelength of a light source supplied as excitation energy.

FIG. 26 shows the quantum yield (IPCE) according to the wavelength of the light source, and as shown in the drawing, it shows that the quantum yield varies according to the wavelength depending on the material. Therefore, it is possible to know whether a substance to be detected is present by using the characteristic of the quantum yield curvature. For example, the quantum yield graph in Figure 26 (A) is the maximum at about 440 nm, has a second peak value at 560 nm, and a third peak value at 620 nm.These characteristics (peak value, wavelength, slope, peak interval, etc.) ) Can be analyzed to determine the presence or absence of the substance to be detected.

Since the quantum yield measurement is as well known, a detailed description thereof will be omitted.

In the above configuration, a display unit 160 for displaying information on the detection target substance is further included.

Preferably, the display unit 160 includes a visual display unit 161 that visually displays information on the flow of electrons according to the detection of the detection target material, and an auditory display unit 162 that is audibly displayed.

In the above configuration, the communication unit 170 for transmitting information on detection of the detection target substance to the outside; characterized in that it is configured to further include.

The communication unit 170 includes a wired communication unit 171 for transmitting information on detection of the detection target substance by wire (private line, dedicated network, Internet, etc.), and wirelessly (wireless communication, mobile communication, It is preferable that it is composed of a wireless communication unit 172 that transmits through short-range wireless communication, Wi-Fi, Bluetooth, etc.).

In the above configuration, the data storage unit 140 for storing information on detection of the detection target substance; characterized in that it is configured to further include.

In the drawings, reference numeral 150 denotes a control unit, and 180 denotes a power supply unit that supplies operating power to each component.

Hereinafter, the technical idea of the "molecular sensor" of the present invention will be described in detail by way of example.

In the description, the same or similar names and symbols are used for components having the same or similar configuration and function.

<Example>

In this embodiment, an FTO (F-doped [SnO₂]) transparent electrode is used as the positive electrode, platinum (Pt) is used as the negative electrode, and titanium dioxide ([TiO₂]) and lithium containing-fullerene hexafluorotitanate phosphate salt ^- one in toluene ^{([Li + @ C60] [} PF6]) to the (material arising as a cause of cancer) configure the sensor electrode unit, and the memorization of material through the sensor electrode used ( Toluene) will be described as an example.

Therefore, in the present embodiment, a configuration further including an excitation energy supply unit for supplying excitation energy to the anode-side movement inducing material will be described as an example. In the present embodiment, the excitation energy supply unit will be described as an example of supplying light energy.

In addition, in this embodiment, a detection unit that detects the flow of electrons moving from the cathode to the anode when the detection target substance (toluene) flows into the sensor electrode unit, and detection information (testing process, detection conditions, detection results, etc.) An example will be described with a display unit configured to display, a data storage unit storing the same, and a communication unit for exchanging information on the detection with an external device.

In addition, in the present embodiment, the detection of toluene contained in air (exhalation) will be described as an example. Accordingly, the sensor electrode unit will be described as an example of having a structure in which air can flow between the cathode and the anode. Air (exhalation) containing the detection target material is supplied to the sensor electrode using a pumping device.

The reason for configuring this embodiment in this way is that other configurations and embodiments according to the technical idea of the present invention can be easily understood from the present embodiment.

Hereinafter, the configuration of the present embodiment will be described in detail with reference to the accompanying drawings as described above.

1) Energy level design

The energy level design process of this embodiment for detecting toluene will be described with reference to FIG. 17 as follows.

The energy level based on the vacuum of the valence band of toluene, a substance to be detected, is -6.55 eV, and the energy level of the conduction band is -0.18 eV. Therefore, an electrode having an energy level higher than -6.55 eV, which is the energy level of the valence band of toluene, which is the detection target material, is required. In this embodiment, platinum (Pt) having an energy level of -5.93 eV in the valence band and -5.12 eV in the conduction band is used as a cathode. Therefore, when toluene, a material to be detected, comes into contact with a cathode made of platinum (Pt), an energy level structure in which electrons can move from the cathode is formed through positive holes in the valence band of toluene, which is a material to be detected, due to the difference in energy level.

Toluene, which is the detection target material to be detected in this embodiment, has a very low energy level of -6.55 eV in the valence band, and thus an anode-side migration inducer having a lower energy level is required. In this embodiment, ^{[Li + @ C60] [PF6} -] of the energy level of the valence band is -7.70eV uses a positive electrode cheukje first mobile inducer. Used as the positive electrode cheukje first mobile inducers ^{[Li + @ C60] [PF6} -] energy level of the valence band of is lower than the energy level of a valence band of -6.55eV toluene the target substance, the valence band of the toluene the electrons that ^{[Li + @ C60] [PF6} -] will have the energy level structure that can move electron hole generated in the valence band.

The positive electrode cheukje first mobile inducer of ^{[Li + @ C60] [PF6} -] Because of the energy level of the conduction band is -4.90eV, the energy level of the valence band of the FTO used as an anode is -4.85eV, the [Li ⁺ @ C60] [PF6 ^-] the electrons in the conduction band can not move directly to the anode of. Therefore, a second movement inducing material on the anode side is required to mediate this.

An anode cheukje first mobile inducers ^{[Li + @ C60] [PF6} -] Since the energy level of the conduction band is -4.90eV, the energy level of the valence band of the positive electrode FTO is -4.85eV, anode cheukje second mobile inducer of the - A material consisting of a valence band with an energy level lower than 4.90 eV and a conduction band with an energy level higher than -4.85 eV is required.

Titanium dioxide ([TiO₂]) has an energy level of -6.21 eV in the valence band and -3.21 eV in the conduction band, which satisfies the above conditions, so this [TiO₂] is used as the second movement inducing material on the anode side. do. Then, the electrons excited in the conduction band of [TiO₂] have an energy level structure capable of moving to the anode.

That is, when the condition is satisfied, the electrons excited in the electron band of [TiO₂], which is the anode-side second transfer inducer, move to the anode, and the positive holes generated in the valence band of [TiO₂], which is the first inducing material on the anode side, [ Li ⁺ @ C60] [PF6 ^-] moves the excited electrons on the conduction band, and wherein [Li ⁺ @ C60] [PF6 of ^-] e of toluene target substance with electron hole generated in the valence band movement, and the toluene It has an energy level at which electrons move in platinum (Pt), which is a cathode, by positive holes in the valence band of.

The positive electrode cheukje first mobile inducer of ^{[Li + @ C60] [PF6} -] Here, the excitation of the light source need 2.8eV or more power with a wavelength of 457nm, and the [TiO₂] cheukje anode 2 move inducer has a 413nm A light source having a wavelength of 3.0 eV or more power is required. Therefore, the light energy supplied from the excitation energy supply unit uses a light source that satisfies the above conditions. For example, a halogen lamp satisfying the above conditions may be used.

FIG. 17 shows the energy level designed through the above process and the corresponding material. As shown in the figure, when toluene, which is a detection target material, is introduced, electrons from the cathode to the anode go through two excitation processes according to the energy level. It is designed to be mobile.

2) Configuration of sensor electrode

As shown in FIG. 18, a positive electrode 121 and a negative electrode 124 are mounted inside the case 125, and operating power is supplied to the positive electrode 121 and the negative electrode 124 through the power supply unit 180. , By connecting the detection unit 110 to detect a current flowing between the anode 121 and the cathode 124, the sensor electrode unit 120 according to the present embodiment is configured.

In the case 125, the surface on which the anode 121, which is a transparent electrode, is mounted, or the entire case is made of a transparent material (eg, glass, quartz, etc.), and the light supplied from the light source 131, which is the excitation energy supply unit 130, It is configured to be irradiated to the anode 121, which is the transparent electrode.

As shown in FIG. 19, the case 125 may be configured such that a light source irradiated from the light source 131 is directly irradiated to the anode 121 by cutting a portion on which the anode is mounted.

In the drawings, unexplained reference numeral 122a denotes a first movement-inducing material on the anode side, 122b denotes a second movement-inducing material on the anode side, respectively, and non-explanatory reference numeral 1 denotes air (exhalation) containing toluene, which is a substance to be detected. Show.

The air (exhalation) 1 passes through the inside of the sensor electrode unit 120 by a pump (not shown) located at the rear of the sensor electrode unit 120, and a detailed description thereof will be omitted.

3) Configuration of detection system

As shown in FIG. 15, the light source 131 of the excitation energy supply unit 130 is irradiated to the sensor electrode unit 120, and the detection unit 110 is connected to the sensor electrode unit 120. Thereafter, the detection system according to the present embodiment is connected to the detection unit 110, the excitation energy supply unit 130, the data storage unit 140, the display unit 160, and the communication unit 170 to the control unit 150. Configure. The power supply unit 180 supplies operating power to each component.

The control unit 150 is preferably composed of a microprocessor or a computer system, and the data storage unit 140 is composed of an internal memory of the control unit 150 or an external memory controlled by the control unit 150. desirable.

The data storage unit 140 stores the detection result of the detection target substance and a data table indicating a correlation between the amount of the detection target substance and the amount of current.

Hereinafter, the operation of the present embodiment configured as described above will be described in detail as follows.

First, when the light source 131 of the excitation energy supply unit 130 is turned on, the light energy irradiated from the light source 131 is [Li ⁺ @C60][ PF6 ^-] and the anode cheukje is here supplying energy to the [TiO₂] 2 moves inducer (122b).

-

Then, electrons in the valence band of [TiO₂], the second movement inducing material on the anode side, are excited with a conduction band, and holes are generated in the valence band of [TiO₂]. The energy level of electrons excited by the conduction band of [TiO₂] is -3.21 eV, which is higher than -4.85 eV, which is the energy level of the valence band of the anode FTO, so that the electrons excited in the conduction band move to the anode FTO.

Electrons in the valence band of [Li+@C60][PF6-], which are the first movement inducers on the anode side, are excited by the conduction band by the light energy irradiated from the light source 131, and the [Li+@C60][PF6-] Yanggong is created in the valence band of. The energy level of the electron excited with the conduction band of [Li+@C60][PF6-] is -4.90 eV, which is higher than -6.21 eV, the energy level of the valence band of [TiO₂], the second movement inducer on the anode side. The excited electrons move to the holes in the valence band of [TiO₂].

In this state, when toluene, a substance to be detected, flows between FTO as a positive electrode and platinum (Pt) as a negative electrode, electrons (energy level: -6.55 eV) in the valence band of the toluene are It moves to the positive hole (energy level: -7.70 eV) created in the valence band of [Li+@C60][PF6-], and a positive hole is generated in the valence band of the toluene.

Then, electrons (energy level: -5.93 eV) in the valence band of platinum (Pt), the cathode, are moved to the positive holes (energy level: -6.55 eV) created in the valence band of the toluene material to be detected.

Thereafter, as long as the excitation energy is supplied from the excitation energy supply unit 130, the above-described process is repeatedly performed, so that a number of electrons proportional to the detection target material toluene continuously moves from the cathode to the anode.

The detection unit 110 detects a current (movement of electrons) flowing between the cathode and the anode.

The control unit 150 detects whether a current flows through the detection unit 110, determines whether toluene, which is a detection target material, is present, and determines the amount of toluene, which is a detection target material, from the amount of current. . That is, the detected amount of current is compared with a data table indicating the relationship between the amount of the detection target substance stored in the data storage unit 140 and the amount of current to calculate how much toluene has been introduced.

Thereafter, the control unit 150 stores the information on the detection (the detection process, detection conditions, detection results, etc.) in the data storage unit 140, displays it through the display unit 160, and displays the information through the communication unit 170. It is exchanged with an external device, and the detection target substance is continuously detected by repeating this process.

At this time, by detecting the current flowing through the electrons donated from the detection target material, it is possible to perform accurate and precise detection in proportion to the number of molecules of the detection target material.

For reference, the data indicating the amount of toluene detected may be configured to diagnose the degree of cancer progression with reference to a data table indicating the amount of toluene and the degree of cancer progression.

The precision of the lung cancer sensor is as follows.

The number of molecules contained in about 500cc of exhalation is about 1.19×10 ²² .

The number of molecules contained in 1 ppt of this 500cc exhalation is,

1.19×10 ²² ×10 ^-12 = 1.19×10 ¹⁰ pieces.

Expressing this in terms of electric charge,

(1.19×10 ¹⁰ )×(1.62×10 ^)-19 C) = about 1.19×10 ^-9 C = 1.9nA.

That is, even if 1 ppt of a memorized substance is contained in 500 cc of exhaled air, it can be detected.

If, in 500cc of exhaled air, 1 ppt of air contains 1% of memorized substances, it represents a charge of about 19pA.

The configuration of the detection unit 110 that detects the amount of charge in the nano-ampere (nA) or pico-ampere (pA) unit is as well known, so a detailed description thereof will be omitted.

On the other hand, [C60] fullerene and lithium ion containing fullerene constituting the movement inducing material (positive side movement inducing material, negative electrode side movement inducing material) of the present invention have a size including electron clouds of about 1 nm, and the lithium ion containing fullerene and The size of a supramolecular made of pigment is about 2 nm.

Therefore, if it is said that there is 1 ppt of memorized material in the 500cc unit, and the migration inducing material is composed of supramolecular (about 2 nm) composed of a lithium ion containing fullerene and a dye, the size of the electrode plate for the memorized material to react at the same time is A size of about (0.22mm ㅧ 0.22mm) is sufficient. In the case where there is 1% of memorized material in 1 ppt of the above 500 cc, a positive electrode (or negative electrode) may be made with a smaller electrode plate.

That is, the number of electrons proportional to the number of molecules of the memorized substance is allowed to move, and by directly detecting the number of the transferred electrons, a lung cancer sensor having a ppt level of precision or higher precision can be constructed.

However, in the above embodiment, it has been described as an example that the detection target material is detected using two anode-side movement inducing materials, but it should be noted that the technical idea of the present invention is not limited thereto. That is, as shown in Figs. 1 to 14, the molecular sensor of the present invention constitutes the molecular sensor of the present invention without a movement inducing material, or by using one positive-side movement inducing material or one negative-side movement inducing material. Or, a molecular sensor of the present invention may be constructed by using a plurality of positive electrode-side movement inducing materials or a plurality of negative electrode-side movement inducing materials, or as many positive-side movement inducing materials and as many negative-side movement as required. It turns out that the molecular sensor according to the present invention can be constructed using all of the inducers. FIG. 16 is a diagram showing an example of the configuration of a sensor electrode unit using both the anode side movement inducing material 122 and the cathode side movement inducing material 123. FIG.

In addition, in the above embodiment, the excitation energy supply unit supplies light energy, and the light source is limited to one. However, it should be noted that the technical idea of the present invention is not limited thereto. That is, it is revealed that the excitation energy supply unit can be configured using several different light sources, as well as the excitation energy can be supplied using different energy sources.

In addition, in the above embodiments, it has been described as an example of detecting a detection target substance contained in air, but it should be noted that the technical idea of the present invention is not limited thereto. That is, it turns out that it can be configured to detect the detection target substance contained in the liquid. For example, in configuring the sensor electrode unit, it is understood that the present invention can be configured by configuring a liquid (blood, urine, saliva, other liquid, etc.) to be contained or temporarily staying rather than configured to pass air. Make it clear.

In addition, in the above embodiments, it has been described as an example that only one detection target substance is detected, but it should be noted that the technical idea of the present invention is not limited thereto. That is, it turns out that it can be configured to detect a plurality of detection target substances. For example, it is revealed that the configuration can be configured to simultaneously detect two or more substances to be detected by using a plurality of anode-side movement inducing materials, a plurality of cathode-side movement inducing materials, and a plurality of excitation energy supply units.

In addition, in the present embodiment, the technical idea of the present invention has been described by taking the detection of toluene, which is a memorized substance, as an example, but the technical idea of the present invention is not limited thereto. In other words, it can be configured to detect tuberculosis causative substances and diagnose tuberculosis early, and can be configured to know the cause of bad breath by detecting bad breath substances), and detect the stress causative agent to detect the level of stress. It has been found that the molecular sensor according to the present invention can be configured to detect poison gases such as sarin gas, dioxin, etc., without limitation to the substance to be detected within the scope of the technical idea of the present invention. Put it.

In addition, in the above embodiments, the detection of the amount of electrons moving by the object to be detected has been described as an example, but it should be noted that the technical idea of the present invention is not limited thereto. In other words, by measuring CV, measuring CA, or measuring CP, or measuring SV, or measuring LSV using potentiostat, it is possible to detect the target substance as well as measure its amount. I can. For example, as shown in Fig. 24, [TiO₂] and [Li+@C60] [PF6-] are moved to the FTO transparent electrode to form the working electrode W, and the counter electrode is made of the platinum electrode Pt. (CE), a reference electrode (RE) with a silver chloride electrode (AgCl), mounted in a quartz glass test tube, and then put the target to be detected in an electrolyte (e.g., acetonitrile) and measure CV to measure the target substance. It is possible to measure the presence and amount of Fig. 25 is an enlarged graph showing a part of the CV curve, showing the reaction according to the energy level design of a substance to be detected ((A) curve) and a substance not to be detected ((B) curve). In the (a) curve, "a" means that when the irradiation and blocking of light (excitation energy) is periodically switched, the excitation of the anode-side moving inducer is caused by the excitation energy of the light, resulting in an increase in current (light irradiation). Block), and "b" indicates when no light is irradiated (the "b" section is an insertion of a state in which the light source is turned off for convenience of explanation). At this time, it is possible to know the presence and amount of a substance to be detected by analyzing the difference between the generated current value or the graph characteristics. (B) The curve indicates that there is no change due to the excitation energy (light irradiation) because it is not a substance to be detected.

In addition, as shown in FIG. 26, it should be noted that the detection target material can be specified using the quantum yield (IPCE) according to the wavelength of the light source supplied as excitation energy as a characteristic element.

1: substance to be detected
110: detection unit 120: sensor electrode unit
121: anode 122: anode side migration inducer
122a: anode-side first transfer-inducing material 122b: anode-side second transfer-inducing material
123: cathode-side transfer-inducing material 124: cathode-side transfer-inducing material
125: case 125a: opening
130: excitation energy supply unit 131: light source
140: data storage unit 150: control unit
160: display unit 161: time display unit
162: hearing display unit 170: communication unit
171: wired communication unit 172: wireless communication unit
180: power supply
W: Working electrode RE: Reference electrode
CE: counter electrode

Claims (37)

delete delete As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
Consisting of an ion-containing fullerene and a dye complex so that the energy level of the valence band is lower than the energy level of the valence band of the substance to be detected, and the energy level of the conduction band is higher than the energy level of the anode. A positive electrode-side movement inducing material;
An excitation energy supply unit consisting of one or more light energies having different wavelengths and brightness, and supplying excitation energy to excite electrons in the valence band of the anode-side transfer inducer to excite the conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material is introduced between the cathode and the anode, the electrons in the valence band of the anode-side transfer-inducing material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side transfer-inducing material is Electrons excited by the conduction band move to the anode, electrons of the detection target material move to the positive holes created in the valence band of the positive-side movement inducing material, and electrons move from the cathode to the positive holes created in the valence band of the detection target material. Molecular sensor, characterized in that the energy level of the redox potential is set so that the process occurs. As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
Consisting of including an ion-containing fullerene and a pigment complex so that the energy level of the valence band is lower than the energy level of the conduction band of the detection target material, and the energy level of the conduction band has an energy level of the redox potential higher than the energy level of the anode. Anode-side movement inducing material;
Consisting of one or more light energies having different wavelengths and brightnesses, excitation energy is supplied so that electrons in the valence band of the anode-side movement inducer are excited with a conduction band, and electrons in the valence band of the detection target material are An excitation energy supply unit supplying excitation energy to excite the conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side movement inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side movement induction is induced. The electrons excited by the conduction band of the material move to the anode, and secondly, the electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and are excited by the conduction band of the detection target material. Molecule, characterized in that the energy level is set so that the electrons are moved to the positive holes created in the valence band of the positive-side movement inducer, and third, the electrons move from the negative electrode to the positive holes created in the valence band of the detection target material. sensor. As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected;
Including a complex of ion-containing fullerene and a dye so that the energy level of the valence band is lower than the energy level of the cathode and the energy level of the conduction band is higher than the energy level of the valence band of the material to be detected. A cathode-side movement inducing material configured;
An excitation energy supply unit consisting of one or more light energies having different wavelengths and brightness, and supplying excitation energy so that electrons in the valence band of the cathode-side movement inducing material excite the conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material flows between the cathode and the anode, first, electrons in the detection target material move to the anode, and second, the valence band of the cathode-side movement inducing material by the excitation energy supplied from the excitation energy supply unit. The electrons in are excited with the conduction band, and the electrons excited with the conduction band of the cathode-side movement inducing material move to the positive holes created in the valence band of the material to be detected, and third, the positive holes created in the valence band of the negative movement inducing material. Molecular sensor, characterized in that the energy level is set so that a process of moving electrons at the cathode is made. As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential lower than that of the conduction band of the material to be detected;
Consisting of an ion-containing fullerene and a dye complex so that the energy level of the valence band is lower than the energy level of the cathode and the energy level of the conduction band is higher than the energy level of the valence band of the material to be detected. A cathode-side movement inducing material;
Consisting of one or more light energies having different wavelengths and brightnesses, excitation energy is supplied so that electrons in the valence band of the cathode-side movement inducing material can be excited with a conduction band, and electrons in the valence band of the detection target material are An excitation energy supply unit supplying excitation energy to excite the conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and are excited by the conduction band of the detection target material. The electrons are moved to the positive electrode, and secondly, the electrons in the valence band of the cathode-side transfer inducer are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and are excited with the conduction band of the cathode-side transfer-inducing material. Molecular sensor, characterized in that the energy level is set so that electrons move to positive holes in the valence band of the material to be detected, and thirdly, electrons move from the cathode to positive holes in the valence band of the cathode-side movement inducing material. . As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
Consisting of an ion-containing fullerene and a dye complex so that the energy level of the valence band is lower than the energy level of the valence band of the substance to be detected, and the energy level of the conduction band is higher than the energy level of the anode. A positive electrode-side movement inducing material;
Consisting of an ion-containing fullerene and a dye complex so that the energy level of the valence band is lower than the energy level of the cathode and the energy level of the conduction band is higher than the energy level of the valence band of the material to be detected. A cathode-side movement inducing material;
Consisting of one or more light energies having different wavelengths and brightnesses, excitation energy is supplied so that electrons in the valence band of the anode-side transfer inducer can be excited with a conduction band, and are in the valence band of the cathode-side transfer inducer. An excitation energy supply unit for supplying excitation energy so that electrons can be excited with a conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side movement inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side movement induction is induced. The electrons excited by the conduction band of the material move to the anode, second, electrons of the detection target material move to the positive holes created in the valence band of the anode-side movement inducing material, and third, by excitation energy supplied from the excitation energy supply unit. Electrons in the valence band of the cathode-side movement inducing material are excited with a conduction band, electrons excited with the conduction band of the cathode-side movement inducing material move to the positive holes created in the valence band of the detection target material, and fourth, the cathode side Molecular sensor, characterized in that the energy level is set so that a process of moving electrons from the cathode to the positive holes created in the valence band of the movement inducing material occurs. As a molecular sensor based on the energy level of the redox potential of the substance to be detected in a vacuum state,
A cathode configured to have an energy level of an oxidation-reduction potential lower than that of the valence band of the material to be detected;
An anode configured to have an energy level of an oxidation-reduction potential higher than that of the valence band of the material to be detected;
Consisting of including an ion-containing fullerene and a pigment complex so that the energy level of the valence band is lower than the energy level of the conduction band of the detection target material, and the energy level of the conduction band has an energy level of the redox potential higher than the energy level of the anode. Anode-side movement inducing material;
Even if the energy level of the valence band is lower than the energy level of the cathode and the energy level of the conduction band is higher than the energy level of the valence band of the material to be detected, the ion-containing fullerene and the pigment complex should be included. A cathode-side movement inducing material configured;
Consisting of one or more light energies having different wavelengths and brightnesses, excitation energy is supplied so that electrons in the valence band of the anode-side transfer inducer can be excited with a conduction band, and are in the valence band of the cathode-side transfer inducer. An excitation energy supply unit for supplying excitation energy to excite electrons in a conduction band, and supplying excitation energy to excite electrons in the valence band of the detection target material to excite the conduction band;
A detector for detecting a flow of electrons according to the detection target material and a quantum yield according to a wavelength of a light source supplied as excitation energy:
A display unit displaying information on detection of the detection target substance;
A communication unit that transmits information on detection of the detection target substance to the outside;
A data storage unit for storing information on detection of the detection target substance; And,
A control unit for controlling operations of the excitation energy supply unit, the detection unit, the display unit, the communication unit, and the data storage unit;
It is made including,
When the detection target material is introduced between the cathode and the anode, first, electrons in the valence band of the anode-side movement inducing material are excited by a conduction band by the excitation energy supplied from the excitation energy supply unit, and the anode-side movement induction is induced. The electrons excited by the conduction band of the material move to the anode, and secondly, the electrons in the valence band of the detection target material are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit, and are excited by the conduction band of the detection target material. The electrons are moved to the positive holes created in the valence band of the anode-side transfer inducer, and third, electrons in the valence band of the cathode-side transfer inducer are excited by the conduction band by the excitation energy supplied from the excitation energy supply unit. The electrons excited by the conduction band of the cathode-side movement inducing material move to the positive holes in the valence band of the detection target material, and fourth, the electrons move from the cathode to the positive holes in the valence band of the cathode-side movement inducer. Molecular sensor, characterized in that the energy level is set so as to be applied. delete The method according to any one of claims 3 to 4, or 7 to 8, wherein the anode-side movement inducing material for inducing the movement of electrons donated from the detection target material to the anode is composed of one or more. Molecular sensor characterized by. The method of claim 10, wherein when the anode-side movement inducing material is composed of a plurality,
The energy level of the conduction band of the first anode-side transfer-inducing material that receives electrons from the detection target material is set higher than the energy level of the valence band of the next anode-side transfer-inducing material,
The energy level of the conduction band of the last anode-side transfer inducer that donates electrons to the anode is set higher than the energy level of the anode,
The energy level of the anode-side transfer inducers in the intermediate stage is set higher than the energy level of the valence band of the anode-side transfer inducer in the next stage, and the energy level of the valence band is set to the previous stage. Molecular sensor, characterized in that it is set lower than the energy level of the conduction band of an anode-side movement inducing material. The molecular sensor according to any one of claims 5 to 8, wherein the cathode-side movement inducing material for inducing the movement of electrons donated from the cathode to the detection target material is composed of one or more. The method of claim 12, wherein when the cathode-side movement inducing material is composed of a plurality,
The energy level of the conduction band of the first cathode-side transfer-inducing material that receives electrons from the cathode is set higher than the energy level of the valence band of the next cathode-side transfer-inducing material,
The energy level of the conduction band of the last cathode-side movement inducing material that donates electrons to the positive holes created in the valence band of the detection target material is set higher than the energy level of the valence band of the detection target material,
The energy level of the cathode-side transfer-inducing material in the intermediate stage is set higher than the energy level of the valence band of the cathode-side transfer-inducing material in the next stage, and the energy level of the valence band is set to the previous stage. Molecular sensor, characterized in that it is set lower than the energy level of the conduction band of the cathode-side movement inducing material. delete delete delete delete delete delete delete The molecular sensor according to any one of claims 3 to 8, wherein the ion contained in the ion-containing fullerene is any one of lithium, sodium, potassium, cesium, magnesium, calcium, or strontium. The method according to any one of claims 3 to 8, wherein the dye is polythiophene such as poly-3-hexylthiophene (P3HT), polyp-phenylene, polyp-phenylene vinylene, polyaniline, Molecular sensor, characterized in that at least one of a high molecular polymer such as polypyrrole, PEDOT, P3OT, POPT, MDMO-PPV, MEH-PPV, or derivatives thereof. delete delete delete delete delete delete delete The method according to any one of claims 3 to 8, wherein the detection unit is CV (Cyclic Voltammetry), CA (Chrono Amperometry), or CP (Chorono Potentiommetry), or SV (Stripping Voltammetry), or LSV. (Linear Sweep Voltammetry) by detecting any one or more of the molecular sensor, characterized in that to detect the presence and amount of the substance to be detected. delete delete delete delete delete delete The substance according to any one of claims 3 to 8, wherein the substance to be detected is a substance that is cancer-causing due to cancer, a substance that is tuberculosis-caused by tuberculosis, or a substance that is bad breath caused by bad breath. , Or a stress-provoking material generated as a cause of stress, or a molecular sensor, characterized in that any one of a pesticide component, or an explosive component.

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