KR20200021265A - Surface modification method of metal parts for insertion of human body - Google Patents

Abstract

One embodiment of the present invention provides a method for modifying the surface of a metal component for human body insertion. According to an embodiment of the present invention, surface modification can be safely performed through a dry plasma process with less residue of harmful substances, thereby safely improving the bone adhesion rate. The method for modifying the surface of the metal component for human body insertion of the present invention comprises the following steps of: sandblasting the surface of the metal component for human body insertion; and controlling surface roughness of the sandblasted metal component through dry plasma treatment.

Description

Surface modification method of metal parts for insertion of human body}

The present invention relates to a method for surface modification of a metal component for human body insertion, and more particularly, to a method for surface modification of a metal component for human body insertion through plasma treatment.

Recently, a large number of living bone grafts such as teeth and bones have been performed, and materials used for living bone grafts include xenograft, allogeneic bone, and autologous bone. Autologous bone graft is the best in terms of bone formation, adhesion and biocompatibility, but there are other bone defects and infections related to the extraction of graft bone. Allografts or xenografts are used instead of autologous bones, and allogene bones are obtained from the same species as the host, and xenografts are obtained by processing animal bones and transplanting them. Osteo-adhesion is inferior and above all, there are ethical problems, inflow of pollutants, and infections. Recently, artificial bone substitutes that are inexpensive and inexpensive and free of infection and disease are being studied. Potassium phosphate compounds are used as artificial bone materials, and alloys such as titanium, alloys thereof, and cobalt chromium have been studied.

However, their biggest problem is that various complications occur due to bone adhesion and biocompatibility with surrounding bone tissue, dissolution and exfoliation of metal ions, and it is difficult to control the biodegradation rate of the implanted artificial substitute. In order to solve this problem, the modification of the surface where the artificial bone graft and the surrounding bone tissue is in contact with the most important, such surface modification is largely a surface treatment method and a material addition method. Surface treatment is a method of blasting the surface with fine particles and increasing the surface area by treating the surface by chemical, electrical or acid corrosion (Guehennec et al. 2007, Dental Materials 23, 844, Albrektsson. 2004, International Journal of Prosthodontics, 17, 536). The most commonly used method is wet surface modification combined with sandblasting and acid corrosion. The acid used at this time is the most frequently used combination of hydrochloric acid and sulfuric acid, which may cause human health problems due to acid residues and environmental pollution by the reaction solution using strong acid. Therefore, there is a need for a study on the surface modification method for improving the bone adhesion rate of the human insertion parts to solve this problem.

Korea Patent Registration No. 10-0700027

The technical problem to be achieved by the present invention is to provide a manufacturing method for improving the bone adhesion rate of the metal component for human body insertion.

The technical problem to be achieved by the present invention is not limited to the technical problem mentioned above, and other technical problems not mentioned above may be clearly understood by those skilled in the art from the following description. There will be.

In order to achieve the above technical problem, an embodiment of the present invention provides a surface modification method of a metal component for human body insertion.

In an embodiment of the present invention, the method for surface modification of the human body insertion metal part comprises sandblasting the surface of the human body insertion metal part, placing the sandblasted metal part on a reaction table inside the vacuum chamber. Maintaining the inside of the vacuum chamber using a vacuum pump, supplying a gas to be plasmaized into the vacuum chamber, maintaining an internal pressure, and generating a plasma to activate the surface of the metal part. It may include a step.

At this time, the gas to be plasma is characterized in that it comprises a fluorine (F) -based gas or chlorine (Cl) -based gas.

At this time, the plasma is characterized in that it is generated through the RF of 1MHz to 1000MHz.

At this time, the step of activating the surface of the metal component is characterized in that the surface roughness of the metal component is performed to 1㎛ to 3㎛.

At this time, the step of activating the surface of the metal component is characterized in that to perform a dimple (dimple) of 100nm to 1000nm is formed on the metal component.

At this time, the fluorine (F) -based gas is characterized in that the gas containing a fluorine (F) element.

At this time, the chlorine (Cl) -based gas is characterized in that the gas containing a chlorine (Cl) element.

In this case, the gas containing the fluorine (F) element may include CF ₄ , C ₄ F ₈ or C ₄ F ₆ .

In this case, the gas containing the chlorine (Cl) element may include Cl ₂ or BCl ₃ .

In this case, the plasma gas may further include an oxygen (O ₂ ) gas or an argon (Ar) gas.

At this time, the mixed gas is characterized in that the fluorine (F) -based gas or chlorine (Cl) -based gas: oxygen gas: argon gas = 4 to 6: 1 to 2: 1:

According to the embodiment of the present invention, it is possible to manufacture a metal part for insertion of the human body with improved bone adhesion rate.

The effects of the present invention are not limited to the above-described effects, but should be understood to include all the effects deduced from the configuration of the invention described in the detailed description or claims of the present invention.

1 is a flowchart illustrating a surface modification method of a metal component for human body insertion according to an exemplary embodiment of the present invention.
Figure 2 is a schematic diagram showing a surface modification method of a metal component for human body insertion according to an embodiment of the present invention.
3 is a graph showing the ratio of F and Ti etching rate according to the concentration of O ₂ in CF ₄ plasma.
4 (A) is a graph showing the Ti etching rate according to the ratio of Cl.
4B is a graph showing Surface roughness (RMS) according to the ratio of Cl.
5 is a SEM image of the surface of a metal component for inserting a human body before performing surface modification according to an embodiment of the present invention.
Figure 6 is a SEM image of the surface of the metal component for human body insertion after performing surface modification according to an embodiment of the present invention.

Hereinafter, with reference to the accompanying drawings will be described the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention. In the drawings, parts irrelevant to the description are omitted in order to clearly describe the present invention, and like reference numerals designate like parts throughout the specification.

Throughout the specification, when a part is said to be "connected (connected, contacted, coupled) with another part, it is not only" directly connected "but also" indirectly connected "with another member in between. "Includes the case. In addition, when a part is said to "include" a certain component, it means that it may further include other components, without excluding the other components unless otherwise stated.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this specification, terms such as "comprise" or "have" are intended to indicate that there is a feature, number, step, action, component, part, or combination thereof described in the specification, and one or more other features. It is to be understood that the present invention does not exclude the possibility of the presence or the addition of numbers, steps, operations, components, components, or a combination thereof.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings.

It describes a surface modification method of a metal component for human body insertion according to an embodiment of the present invention.

1 is a flowchart illustrating a surface modification method of a metal component for human body insertion according to an exemplary embodiment of the present invention.

Referring to FIG. 1, in the method of modifying the surface of a metal component for inserting a human body, sandblasting the surface of the metal component for inserting a human body is performed (S100) and controlling the surface roughness of the sandblasted metal component through a dry plasma treatment. It may include the step (S200).

In this case, the step of controlling the surface roughness through the dry plasma treatment, positioning the sandblasted metal parts on the reaction table in the vacuum chamber, by using a vacuum pump to the inside of the vacuum chamber in a vacuum state The method may include maintaining, supplying a gas to be plasmaized into the vacuum chamber, maintaining an internal pressure, and generating a plasma to activate a surface of the metal part.

Figure 2 is a schematic diagram showing a surface modification method of a metal component for human body insertion according to an embodiment of the present invention.

Referring to FIG. 2, the step of controlling the surface roughness through the dry plasma treatment may include first placing the sandblasted metal part 200 on the reaction table 110 inside the vacuum chamber 100. Maintaining the interior of the vacuum chamber 100 in a vacuum state by using a pump 120, supplying a gas to be plasmaized into the vacuum chamber, maintaining an internal pressure, and generating a plasma 300 to generate the metal. Activating the surface of the component 200.

For example, the metal insert for human body may include Ti, Ti alloy, or CoCr.

At this time, the gas to be plasma is characterized in that it comprises a fluorine (F) -based gas or chlorine (Cl) -based gas.

For example, the plasma 300 may be an inductively coupled plasma generated through the RF power source 150 and the induction coil 140 in the vacuum chamber 100. In this case, the pulse generated through the RF power supply 150 and the induction coil 140 may reach the gas to be plasmaized in the vacuum chamber 100 through the visualization window 130.

At this time, the plasma 300 is characterized in that it is generated through the RF (Radio Frequency) of 1MHz to 1000MHz.

In this case, when using an RF of less than 1MHz, due to the low frequency, the amount of energy may not be enough, so that plasma may not occur.

At this time, when using an RF of more than 1000MHz, due to the high frequency, the energy is excessively large may cause damage to the metal parts.

At this time, the step of activating the surface of the metal component (S500) is characterized in that the surface roughness of the metal component is performed to 1㎛ to 3㎛.

In this case, when the surface roughness of the metal component is less than 1 μm, the surface of the metal component may be so smooth that the bone adhesion rate may decrease.

In this case, when the surface roughness of the metal component is greater than 3 μm, the surface of the metal component may be too rough so that the bone adhesion rate may decrease.

In this case, the step (S500) of activating the surface of the metal component is characterized in that the dimple (dimple) of 100nm to 1000nm is formed on the metal component.

At this time, when the size of the dimple is less than 100nm, the surface of the metal part is too smooth, the bone adhesion rate may be lowered.

At this time, when the size of the dimple is more than 1000nm, the surface of the metal part is too rough, the bone adhesion rate may be lowered.

At this time, the fluorine (F) -based gas is characterized in that the gas containing a fluorine (F) element.

At this time, the chlorine (Cl) -based gas is characterized in that the gas containing a chlorine (Cl) element.

In this case, the gas containing the fluorine (F) element may include CF ₄ , C ₄ F ₈ or C ₄ F ₆ .

In this case, the gas containing the chlorine (Cl) element may include Cl ₂ or BCl ₃ .

In this case, the plasma gas may further include an oxygen (O ₂ ) gas or an argon (Ar) gas.

At this time, the mixed gas is characterized in that the fluorine (F) -based gas or chlorine (Cl) -based gas: oxygen gas: argon gas = 4 to 6: 1 to 2: 1:

In this case, when the ratio of the fluorine (F) -based gas or the chlorine (Cl) -based gas is less than 4, the ratio of oxygen gas is relatively increased, so that the radical (COF ₂ , COCl ₂ ) may be produced to reduce the proportion of F or Cl. In addition, TiO ₂ may be formed on the Ti surface to decrease the etching rate. 3 is a graph showing the ratio of F and Ti etching rate according to the concentration of O ₂ in CF ₄ plasma. Referring to FIG. 3, it can be seen that the Ti etching rate and the density of F atoms are the highest at a ratio of CF ₄ : O ₂ of 4 to 6: 1.

In this case, when the ratio of the fluorine (F) -based gas or chlorine (Cl) -based gas is greater than 6, even if the ratio of F or Cl is increased, the Ti etching rate may not increase, and in addition, the surface of the metal part may be too high. Smoothing can reduce the bone adhesion rate.

Specifically, Figure 4 (A) is a graph showing the Ti etching rate according to the ratio of Cl. Referring to FIG. 4 (A), it can be seen that even though the ratio of Cl is increased, the Ti etching rate does not increase any more.

4B is a graph showing Surface roughness (RMS) according to the ratio of Cl. Referring to FIG. 4B, as the ratio of Cl increases, the surface roughness (RMS) increases together and decreases again. As such, when the surface roughness (RMS) is reduced and the surface of the metal component becomes too smooth, the bone adhesion rate may be reduced.

Metals are highly reactive with radicals of F and Cl atoms, so they can be easily etched using gases containing Group 17 elements such as fluorine (F) and chlorine (Cl). In addition, while using conventional hydrofluoric acid (HF), hydrochloric acid (HCl), there is an advantage that the environmentally friendly surface treatment is possible when using gas.

<Example>

The surface of the metal part made of Ti was first sandblasted with ZrO 2 media having an average size of 150 μm and then sandblasted with SiO 2 media having an average size of 40 μm. The secondary sandblasted metal parts were placed in an inductively coupled plasma (ICP) chamber and then supplied with a gas to be mixed in a ratio of CF ₄ : O ₂ : Ar = 6: 1: 1. The internal pressure was maintained at 20 mTorr and plasma-treated for 20 to 30 minutes under conditions of 13.56 MHz 1200 Ws and 250 Wb.

5 is a SEM image of the surface of the metal component for inserting a human body before performing surface modification according to an embodiment of the present invention.

Figure 6 is a SEM image of the surface of the metal component for human body insertion after performing surface modification according to an embodiment of the present invention.

Referring to FIGS. 5 and 6, it can be seen that when surface treatment of a metal component for inserting a human body according to an embodiment of the present invention, a surface shape similar to bone tissue may be exhibited through surface oxidation and dimple formation.

According to an embodiment of the present invention, it is possible to provide a method for manufacturing a metal component for inserting a human body, which reduces residual harmful substances through a dry plasma process.

According to an embodiment of the present invention, it is possible to provide a method for manufacturing a metal component for inserting a human body in which bone adhesion is improved through dimple formation.

The foregoing description of the present invention is intended for illustration, and it will be understood by those skilled in the art that the present invention may be easily modified in other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are exemplary in all respects and not restrictive. For example, each component described as a single type may be implemented in a distributed manner, and similarly, components described as distributed may be implemented in a combined form.

The scope of the present invention is represented by the following claims, and it should be construed that all changes or modifications derived from the meaning and scope of the claims and equivalent concepts thereof are included in the scope of the present invention.

100: vacuum chamber
110: reaction table
120: vacuum pump
130: Visualization window
140: induction coil
150: RF power
200: metal parts for human body insertion
300: plasma

Claims (11)

Sandblasting the surface of the metal component for human body insertion; And
And controlling a surface roughness of the sandblasted metal part through a dry plasma treatment. The method of claim 1,
Controlling the surface roughness through the dry plasma treatment,
Placing the sandblasted metal part on a reaction table inside a vacuum chamber;
Maintaining the interior of the vacuum chamber in a vacuum state using a vacuum pump;
Supplying a gas to be plasmaized in the vacuum chamber and maintaining an internal pressure; And
Generating a plasma to activate a surface of the metal part,
The plasma gas is a surface modification method of the human body insertion metal component comprising a fluorine (F) -based gas or a chlorine (Cl) -based gas. The method of claim 2,
The plasma is a surface modification method of the human body insertion metal component, characterized in that generated through RF of 1MHz to 1000MHz. The method of claim 2,
The step of activating the surface of the metal component is a surface modification method of the human body insertion metal component, characterized in that to perform so that the surface roughness of the metal component is 1㎛ to 3㎛. The method of claim 2,
The step of activating the surface of the metal component is a surface modification method for inserting a metal component, characterized in that the dimple (dimple) of 100nm to 1000nm is formed on the metal component. The method of claim 2,
The fluorine (F) -based gas is a surface modification method of the human body insert metal component, characterized in that the gas containing a fluorine (F) element. The method of claim 2,
The chlorine (Cl) -based gas is a surface modification method of the human body insertion metal component, characterized in that the gas containing a chlorine (Cl) element. The method of claim 6,
The gas containing the fluorine (F) element is CF ₄ , C ₄ F ₈ or C ₄ F ₆ Surface modification method for inserting a human body metal component characterized in that it comprises. The method of claim 7, wherein
The gas containing the chlorine (Cl) element is a surface modification method of the human body insert metal component, characterized in that containing Cl ₂ or BCl ₃ . The method of claim 2,
Wherein the gas to be plasmaized is a mixed gas further comprises oxygen (O ₂ ) gas or argon (Ar) gas surface modification method of the human insert metal component. The method of claim 10,
The mixed gas is a fluorine (F) -based gas or chlorine (Cl) -based gas: oxygen gas: argon gas = 4 to 6: the surface modification of the human body insert metal parts, characterized in that the mixture of 1 to 2: 1 Way.

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