KR20200007501A - Cosmetic composition for improvement of skin itching and moisturizing with the extract of Corydalis platycarpa - Google Patents

Abstract

The present invention relates to a cosmetic composition for alleviating skin itch or moisturizing skin, containing a Corydalis platycarpa extract.

Description

Cosmetic composition for improving itching and moisturizing skin containing bulging bag extract as an active ingredient {Cosmetic composition for improvement of skin itching and moisturizing with the extract of Corydalis platycarpa}

The present invention relates to a cosmetic composition having improved skin itch and skin moisturizing effect using the bulge bag extract.

Itching refers to the condition of the skin that causes discomfort to be scratched. Itching is caused by light contact, temperature changes, stress, or other chemical, physical or electrical stimuli. In addition, itching may be accompanied by symptoms of skin diseases such as atopic dermatitis, psoriasis and contact dermatitis, or sensitive skin holders. Sensitive skin holders are those who have the potential for skin disorders without any clinical or histological symptoms of skin lesions, and after the use of cleansing agents such as cosmetics, soaps and shampoos, they complain of sensation of itching in addition to eye irritation.

On the other hand, the signal transmission process for the itch caused by the stimulus has been revealed in part, the drug for the treatment of the itch through its control is being developed. Recent studies have shown that the cause of itching is transmitted to the brain through the central nervous system (CNS), which inhibits the signaling of pain and itching from the central nervous system. Therefore, when you feel itching, pain (such as scratching) can alleviate itching. However, itching repeats a vicious cycle that increases the material that causes itching, making it more sensitive to irritation. In addition, proteinase-activated receptors (PARs) play an important role in the stimulus-induced itch signaling process, and then via G-protein, phosphatidylinositol diphosphate and phosphatidylinositol diphosphate. Signaling processes involving diacylglycerol and protein kinase C have been identified.

Corydalis platycarpa (Maxim.) Makino is a two-year-old herbaceous genus of opium poppy, mainly distributed in Jeju Island, South Sea, and Ulleungdo in Korea. The name 'bull's pocket' comes from the 'God', which was worn by women in the old days. The bulrush bag has a unique flower shape, corolla color is yellow with honey at one end and lip shape at the other. Fruits are arranged in two rows of seeds and are generally elongated beads with pods of glossy black round granules. The roots have a very bad odor and are not accessible to insects or other insects, so the plant grows intact. In private houses, it is used as a folk remedy because it is said that the bite of swelling is removed by applying a fire bag when bitten by poisonous snakes or insects.

On the other hand, in recent years, the case of side effects caused by the chemical composition of cosmetics is often known, the consumer's interest in cosmetics manufactured with natural ingredients is increasing. Accordingly, many cosmetic products using natural products have been developed to reduce skin irritation caused by various chemicals. Natural materials have less side effects on the skin, and as the consumer's response to cosmetics using natural materials has increased recently, the development value of cosmetic ingredients has increased further. However, there is no research and development using lump bags as cosmetic ingredients. .

Republic of Korea Patent Publication No. 10-2007-0028816 (published on March 13, 2007) relates to a cream and soap composition with the addition of herbs, perfumes for skin moisturizing and soothing skin to skin dryness and itching caused by atopic skin, With atopic dermatitis, the skin is dried or itching, and herbal medicines such as cloth pollen, three kingdoms, white paper, donkey, bamboo salt, and fragrances, lavender oil and tea tree oil, are excellent creams, solid soap and Water soap compositions are disclosed. Republic of Korea Patent Publication No. 10-2017-0049868 (published on May 11, 2017) relates to a cosmetic composition having a skin moisturizing and sedative effect comprising an herbal extract as an active ingredient, the extract of Angelica extract, rhubarb extract Disclosed is a cosmetic composition having a skin moisturizing effect and an itch improvement effect comprising a mixed extract as an active ingredient.

The present invention aims to discover extracts of natural products with excellent skin itching and skin moisturizing effects, and to develop and provide cosmetic compositions containing them as active ingredients.

The present invention provides a cosmetic composition for improving skin itch, which comprises an extract of Corydalis platycarpa (Maxim.) Makino.

In the cosmetic composition for improving skin itch of the present invention, the mass bulge bag extract is preferably contained in 0.001 to 30% by weight based on the total weight of the cosmetic composition.

In the cosmetic composition for improving skin itch of the present invention, the bulge bag extract is preferably, a solvent extraction method for extracting by adding water or an organic solvent; Or it may be obtained by using an ultra-high pressure extraction method. At this time, the organic solvent, for example, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and these An extraction solvent selected from the group consisting of mixtures of can be used.

In the cosmetic composition for improving skin itch of the present invention, the ultra-high pressure extraction method is preferably treated for 20 to 30 hours at a pressure of 100 ~ 3000 MPa, temperature 40 ~ 90 ℃, lowering the pH of the water inside the ultra-high pressure to 1 to 6 Good to do.

In the cosmetic composition for improving skin itch of the present invention, the cosmetic composition, for example, solutions, suspensions, emulsions, pastes, lotions, gels, water-soluble liquids, creams, essences, surfactant-containing cleansing, oils, oil-in-water A base cosmetic formulation of any one selected from (O / W) and water-in-oil (W / O) types; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulation for mask pack; Body wash formulations; Peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; Skin cover; Color cosmetic formulations selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencils; Scalp formulations; It may be any one selected from among.

In another aspect, the present invention provides a cosmetic composition for moisturizing the skin, characterized in that it contains an extract of Corydalis platycarpa (Maxim.) Makino.

In the skin moisturizing cosmetic composition of the present invention, the mass bulge bag extract is preferably contained in 0.001 to 30% by weight based on the total weight of the cosmetic composition.

In the skin moisturizing cosmetic composition of the present invention, the mass bulge bag extract is preferably a solvent extraction method for extracting by adding water or an organic solvent; Or it may be obtained by using an ultra-high pressure extraction method. At this time, the organic solvent, for example, anhydrous or hydrous lower alcohol having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and their Extractive solvents selected from the group consisting of mixtures may be used.

In the cosmetic composition for skin moisturizing of the present invention, the ultra-high pressure extraction method is preferably treated for 20 to 30 hours at a pressure of 100 ~ 3000 MPa, temperature 40 ~ 90 ℃, lowering the pH of the water in the ultra-high pressure to 1 to 6 It is good.

In the skin moisturizing cosmetic composition of the present invention, the cosmetic composition is preferably a solution, suspension, emulsion, paste, lotion, gel, water-soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O / W) and water-in-oil (W / O) type of cosmetic formulation of any one; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulation for mask pack; Body wash formulations; Peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; Skin cover; Color cosmetic formulations selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencils; Scalp formulations; It may be any one selected from among.

The present invention contains an extract of Corydalis platycarpa (Maxim.) Makino to improve the skin itching and provides a cosmetic composition excellent in skin moisturizing effect.

1 is an experimental result showing the effect of reducing the expression of TRPV1 of the bag fire bag extract.
Figure 2 is an experimental result showing the AQP-3 expression effect of the mass bag extract.

The present invention provides a cosmetic composition for improving skin itch, which comprises an extract of Corydalis platycarpa (Maxim.) Makino. In another aspect, the present invention provides a cosmetic composition for moisturizing the skin, characterized in that it contains an extract of Corydalis platycarpa (Maxim.) Makino.

In the cosmetic composition of the present invention, the mass fire bag extract, for example, may be an extract obtained from any one or more selected from the leaves, fruits, stems, roots and flowers of the mass fire bag.

In the cosmetic composition of the present invention, the method of obtaining a mass fire bag extract is not limited to a particular one, and various extraction methods commonly used in the art to which the present invention pertains may be used. For example, purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, and hexane solvents may be extracted alone or as a mixed solvent in which two or more thereof are used as an extraction solvent. Preferably it is extracted for 3 days at room temperature in 70% (v / v) ethanol aqueous solution.

In addition, the bulrush bag extract of the present invention includes not only the extract by the above-mentioned extraction solvent but also the extract extracted by adding another method. Extraction by, for example, ultrahigh pressure extraction; Separation using ultrafiltration membranes with constant molecular weight cut-off values; It also includes extracts that have been extracted or separated / purified in addition to various methods, such as separation by chromatography designed for separation according to size, charge, hydrophobicity or affinity. In the case of ultra-high pressure extraction of the mass fire bag, the treatment is preferably carried out for 20 to 30 hours at a pressure of 100 to 3000 Mpa, a temperature of 40 to 90 ℃, more preferably 23 to 25 at a pressure of 500 to 1000 Mpa, a temperature of 40 to 60 It is good to deal with time. In addition, the pH at the time of ultra-high pressure extraction is not limited to a specific pH, but preferably it is preferable to lower the pH of the water inside the ultra-high pressure to 1-6. The present invention is ultra-high pressure extract as described above using a solvent selected from purified water, methanol, ethanol, glycerin, ethyl acetate, butylene glycol, propylene glycol, dichloromethane, hexane and mixtures thereof, and then cooled and filtered. The filtrate may be transferred to a concentration tank, and concentrated under reduced pressure and lyophilized at 50 ° C. or lower. In addition, the present invention may be formulated in the liquid phase using one or more solvents selected from purified water, ethanol, butylene glycol, propylene glycol obtained extract, reduced pressure concentrate or lyophilized.

On the other hand, in the cosmetic composition of the present invention, the mass bulge bag extract is preferably added 0.001 ~ 30% by weight relative to the total weight. When it is included in less than 0.001% by weight, the effect of exhibiting the various skin functionalities identified in the present invention is insignificant, and when it is more than 30.0% by weight, it is not economical because it is less efficient than the amount of material input.

On the other hand, the cosmetic composition of the present invention, for example, solutions, suspensions, emulsions, pastes, lotions, gels, water-soluble liquids, creams, essences, surfactant-containing cleansing, oil, oil-in-water (O / W) type and oil Any one of the basic cosmetic formulations selected from heavy water (W / O) type; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulation for mask pack; Body wash formulations; Peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; Skin cover; Color cosmetic formulations selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencils; Scalp formulations; It may be any one selected from among.

In addition, the cosmetic composition of the present invention may contain auxiliary agents commonly used in the cosmetic field such as hydrophilic or lipophilic active agents, preservatives, antioxidants, solvents, fragrances, fillers, blockers, pigments, odorants, dyes and the like. The amounts of these various adjuvants are amounts conventionally used in the art, such as 0.001 to 30% by weight relative to the total weight of the composition. In any case, the adjuvant and its proportions will be selected so as not to adversely affect the desirable properties of the cosmetic composition according to the invention.

On the other hand, in the cosmetic composition of the present invention, when the formulation is a paste, cream or gel, the carrier component is animal oil, vegetable oil, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, and silica , Talc or zinc oxide may be used.

In addition, in the cosmetic composition of the present invention, when the formulation is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as the carrier component. For example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, Fatty acid esters of benzoate, propylene glycol, 1,3-butylene glycol oil, glycerol aliphatic esters, polyethylene glycols or soribitan may be used.

In the cosmetic composition of the present invention, when the dosage form is a suspension, a liquid diluent such as water, ethanol or propylene glycol, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, and polyoxyethylene sorbitan ester, The same suspending agents, microcrystalline cellulose, aluminum metahydroxy, bentonite, agar or tragacanth and the like can be used.

On the other hand, in the cosmetic composition of the present invention, when the dosage form is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier function, and in particular, in the case of a spray It may additionally include propellants such as chlorofluorohydrocarbons, propane / butane or dimethyl ether.

On the other hand, in the cosmetic composition of the present invention, when the formulation is a surfactant-containing cleansing, the carrier component is an aliphatic alcohol sulfate, an aliphatic alcohol ether sulfate, a sulfosuccinic acid monoester, an isethionate, an imidazolinium derivative, a sarcosinate, Fatty acid amide ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

In addition, in the cosmetic composition of the present invention, in the case of a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation or soap, it may be wiped off, peeled off or washed with water after application to the skin. In one example, the soap is liquid soap, powdered soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, the surfactant-free cleansing formulation is a cleansing cream, Cleansing lotion, cleansing water, and cleansing gel.

Moreover, the cosmetic composition of this invention can be used overlapping with other cosmetic compositions other than this invention. In addition, the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use may vary depending on the skin condition or taste of the user.

On the other hand, in the cosmetic composition of the present invention, the cosmetic composition may be for skin itching improvement or skin moisturizing.

Hereinafter, the present invention will be described in more detail in the following Examples and Experimental Examples. However, the scope of the present invention is not limited only to the following Examples and Experimental Examples, and includes all modifications of the technical spirit equivalent thereto.

[Example 1: Preparation of the mass fire bag extract]

After crushing the bulge bag outpost and crushed, 100g was extracted in a 70% (v / v) ethanol solution of about 10 times at room temperature for 3 days. The extract obtained by extraction was filtered with whatman # 5 filter paper. The filtered extract was concentrated under reduced pressure and freeze dried at 50 占 폚 or lower. Molten bag extract was prepared by dispersing and dissolving the extract under reduced pressure and lyophilized product using at least one solvent selected from purified water, ethanol, butylene glycol, and propylene glycol.

Experimental Example 1: Confirmation of the TRPV1 Expression Inhibitory Effect of the Massif Buff Extract

In the present experimental example, to determine the inhibitory effect of TRPV1 expression of the bulge bag extract prepared in Example 1.

Human-derived fibroblasts were placed in a petri dish for culture and cultured until about 80% growth. Subsequently, the mass fire bag extract prepared in Example was diluted to 10, 30, and 100 μg / ml, respectively, and treated with capsaicin for expression of TRPV1. The buffer solution was treated as a control and 100 nM capsaicin (M2028, Sigma) as a negative control, respectively. After incubation for 24 hours, the protein was lysed using lysis buffer. Thereafter, the protein was quantified by the protein BCA method, and 20 ㎍ of protein was taken for SDS-PAGE. After transfer to the PVDF membrane (anti-TRPV1) 1: 1000 and refrigerated for 24 hours in refrigeration and then detected.

The experimental results are shown in FIG. 1. As shown in Figure 1, the massif bag extract was found to reduce the expression of TRPV1 concentration-dependent.

Therefore, it was confirmed that the composition containing the bulge bag extract of the present invention exhibits an excellent skin itch improvement effect.

Experimental Example 2: Confirmation of the AQP-3 Expression Effect of the Massif Buff Extract

In this experimental example was to determine the AQP-3 expression effect of the mass fire bag extract prepared in Example 1.

HaCaT cells were dispensed at 2 * 10 ⁵ cells / ml in 6 wells of 2 ml and stabilized for 6 hours, followed by reaction for 6 hours. Cells were obtained using PBS, and then reacted with ice lysis buffer for 30 minutes on ice to destroy cell membranes and centrifuged at 1,200 rpm for 15 minutes. Thereafter, only the supernatant was transferred separately and the protein was quantified using BCA assay. A certain amount of protein was mixed with SDS-gel loading buffer and inactivated by heating at 100 ° C. for 3 minutes, followed by electrophoresis using SDS-polyacrylamide gel. SDS-polyacrylamide gel was transferred to PVDF membrane at 60 mM for 90 minutes and blocked for 1 hour in 5% skim milk. The primary antibody (Aquaporin-3) was reacted on the blocked PVDF membrane at 4 ° C. for 24 hours, and the 1X TTBS solution was exchanged three times at 10 minute intervals and washed for 30 minutes. The primary-specific secondary antibody was reacted in 5% skim milk for 2 hours and washed again with 1X TTBS solution for 30 minutes at 10 minute intervals. Thereafter, the PVDF membrane was reacted with ECL solution, and the band was analyzed using a Chemi Doc ^TM XRS + machine.

The experimental results are shown in FIG. 2. According to FIG. 2, the bulge bag extract increased the expression of AQP-3 in a concentration-dependent manner. In addition, it can be seen that at 100 ㎍ / ㎖ concentration of the mass fire bag extract, it showed almost similar efficacy as 1 μM of Dexamethason positive control.

Therefore, it was confirmed that the composition containing the bulge bag extract of the present invention exhibits an excellent skin moisturizing effect.

Example 2 Preparation of Cosmetic Composition Containing Mass Extract

In this example, the mass fire bag extract of Example 1 was prepared in a cosmetic composition containing 5.0% by weight. On the other hand, in order to confirm the efficacy of the cosmetic composition containing the bulrush bag extract, a cosmetic composition (comparative example) containing no bulrush bag extract was prepared. Table 1 shows the contents for the cosmetic composition of Example 2 and Comparative Examples.

Composition of Example 2 and Comparative Example division ingredient Example 2 Content (% by weight) Comparative Example Content (% by weight) A Example 1 5.0 - EDTA-2Na 0.02 0.02 Purified water to 100 to 100 B Cetostearyl alcohol 2.0 2.0 Glyceryl Stearate 1.5 1.5 Microcrystallin 0.7 0.7 Squalane 5.0 5.0 Liquid paraffin 3.0 3.0 Trioctanoine 5.0 5.0 Polysorbate 1.2 1.2 Sorbitan stearate 0.5 0.5 Tocopheryl Acetate 0.2 0.2 Cyclomethicone 3.0 3.0 BHT 0.05 0.05 C Incense, preservative Appropriate Appropriate

Experimental Example 3: Confirming the Effect of Inhibiting Skin Scratches of Cosmetic Composition Containing Mass Extract

In the present experimental example, the human application test was performed on the effect of inhibiting the skin itch of the cosmetics containing the extract of bulrush bag.

Forty skin care subjects with atopic lesions were treated with 20 cosmetic compositions prepared in Example 2 containing a bulge bag extract, and the remaining 20 subjects were subjected to a video for 3 hours after applying the comparative cosmetic composition. The number of scratches was observed by photographing. The results according to the experiment are shown in Table 2 below.

Results of measuring the number of scratches according to the inclusion of bulge bag extract Example 2 Comparative example Scratches / h 5 13

As a result of the experiment, the skin diseased patients who applied the composition of Example 2 containing the mass bag extract had significantly fewer scratches than the skin diseased people who applied the comparative composition.

Therefore, it was confirmed that the cosmetic composition containing the bulge bag extract of the present invention exhibits excellent skin itch improvement and therapeutic effect.

[Experimental Example 4: Confirming the effect of improving the skin moisturizing power of the cosmetic composition containing the mass fire bag extract]

In the present experimental example, the effect of improving the skin moisturizing power of the cosmetic composition containing the bulge bag extract prepared in Example 2 was intended.

Twenty to twenty-five people in their twenties and forties with no skin disease were divided into two sets of 20 persons per group, and the cosmetic composition of Example 2 and Comparative Example was applied to the face and forearm for each group. The rate of moisture increase was evaluated by measuring the skin conductivity using a moisture meter (conneometer, CM820 courage Khazaka electronic GmbH, Germany) at constant temperature and humidity conditions (24 ℃, 40% humidity) before application. Table 3 shows the experimental results.

Improvement of Skin Moisturizing Effect According to the Content of Bulk Bag Extract Sample name 1 week later 2 weeks later 4 weeks later Example 2 52 55 58 Comparative example 26 28 33

As a result of the experiment, the cosmetic composition of Example 2 of the present invention was confirmed that the skin conductivity increase rate is very excellent compared to the comparative cosmetic composition. In general, the skin conductivity is proportional to the skin moisture content, it can be seen from the above results that the cosmetic composition containing the bulge bag extract maintains the skin moisture content to exhibit an excellent skin moisturizing effect.

As described above, the cosmetic composition containing the mass bulge bag extract of the present invention has excellent skin itching effect and skin moisturizing effect, and as a cosmetic composition using natural products to reduce skin irritation by various chemicals, the risk of side effects is low. It was confirmed to be effective on the skin and the like.

Claims (12)

A cosmetic composition for improving skin itch, characterized by containing an extract of Corydalis platycarpa .
The method of claim 1,
The bulge bag extract,
Cosmetic composition for improving the skin itch, characterized in that contained in 0.001 to 30% by weight based on the total weight of the cosmetic composition.
The method of claim 1,
The bulge bag extract,
A solvent extraction method for extracting by adding water or an organic solvent; Or ultra-high pressure extraction method; cosmetic composition for improving skin itching, characterized in that obtained by using.
The method of claim 3,
The organic solvent,
Extract solvents selected from the group consisting of anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and mixtures thereof Cosmetic composition for improving skin itch, characterized in that using.
The method of claim 3,
The ultra high pressure extraction method,
20 to 30 hours at a pressure of 100 ~ 3000 MPa, temperature 40 ~ 90 ℃, the cosmetic composition for improving skin itching characterized in that the treatment by lowering the pH of the water inside the ultra-high pressure to 1-6.
The method of claim 1,
The cosmetic composition,
Solution, suspension, emulsion, paste, lotion, gel, water soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O / W) type and water-in-oil (W / O) type Basic cosmetic formulations; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulation for mask pack; Body wash formulations; Peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; Skin cover; Color cosmetic formulations selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencils; Scalp formulations; Cosmetic composition for improving skin itch, characterized in that any one selected from.
A skin moisturizing cosmetic composition comprising an extract of Corydalis platycarpa .
The method of claim 7, wherein
The bulge bag extract,
A cosmetic composition for skin moisturizing, comprising 0.001 to 30% by weight based on the total weight of the cosmetic composition.
The method of claim 7, wherein
The bulge bag extract,
A solvent extraction method for extracting by adding water or an organic solvent; Or ultra-high pressure extraction method; skin moisturizing cosmetic composition, characterized in that obtained by using.
The method of claim 9,
The organic solvent,
Extract solvents selected from the group consisting of anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, acetone, ethyl acetate, chloroform, butyl acetate, diethyl ether, dichloromethane, hexane and mixtures thereof Cosmetic composition for skin moisturizing using.
The method of claim 9,
The ultra high pressure extraction method,
Treatment for 20 to 30 hours at a pressure of 100 ~ 3000 MPa, a temperature of 40 ~ 90 ℃, lowering the pH of the water inside the ultra-high pressure to 1 to 6, characterized in that the cosmetic composition for moisturizing skin.
The method of claim 7, wherein
The cosmetic composition,
Solution, suspension, emulsion, paste, lotion, gel, water soluble liquid, cream, essence, surfactant-containing cleansing, oil, oil-in-water (O / W) type and water-in-oil (W / O) type Basic cosmetic formulations; skin; Lotion; Eye cream; Soothing gel; Ointment; Formulation for mask pack; Body wash formulations; Peeling gel; Oil-in-water and water-in-oil makeup bases; foundation; Skin cover; Color cosmetic formulations selected from lipstick, lip gloss, face powder, two-way cake, eye shadow, cheek color and eyebrow pencils; Scalp formulations; Cosmetic composition for skin moisturizing it is any one selected from.

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