KR20190115037A - 면역 활성을 증가시키는데 이용되는 TGFβ 및 ActRII - Google Patents
면역 활성을 증가시키는데 이용되는 TGFβ 및 ActRII Download PDFInfo
- Publication number
- KR20190115037A KR20190115037A KR1020197025689A KR20197025689A KR20190115037A KR 20190115037 A KR20190115037 A KR 20190115037A KR 1020197025689 A KR1020197025689 A KR 1020197025689A KR 20197025689 A KR20197025689 A KR 20197025689A KR 20190115037 A KR20190115037 A KR 20190115037A
- Authority
- KR
- South Korea
- Prior art keywords
- amino acid
- seq
- polypeptide
- patient
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000004887 Transforming Growth Factor beta Human genes 0.000 title claims abstract description 185
- 108090001012 Transforming Growth Factor beta Proteins 0.000 title claims abstract description 185
- 230000005965 immune activity Effects 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 310
- 238000000034 method Methods 0.000 claims abstract description 250
- 201000011510 cancer Diseases 0.000 claims abstract description 182
- 230000028993 immune response Effects 0.000 claims abstract description 118
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 323
- 239000005557 antagonist Substances 0.000 claims description 304
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 260
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 254
- 229920001184 polypeptide Polymers 0.000 claims description 253
- 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 claims description 185
- 150000001413 amino acids Chemical class 0.000 claims description 173
- 244000052769 pathogen Species 0.000 claims description 139
- 102100034134 Activin receptor type-1B Human genes 0.000 claims description 134
- 239000003446 ligand Substances 0.000 claims description 132
- 230000001717 pathogenic effect Effects 0.000 claims description 129
- 230000027455 binding Effects 0.000 claims description 117
- 239000000488 activin Substances 0.000 claims description 110
- 108010059616 Activins Proteins 0.000 claims description 109
- 102100026818 Inhibin beta E chain Human genes 0.000 claims description 107
- 238000009739 binding Methods 0.000 claims description 97
- 239000000427 antigen Substances 0.000 claims description 81
- 108091007433 antigens Proteins 0.000 claims description 81
- 102000036639 antigens Human genes 0.000 claims description 81
- 102100040898 Growth/differentiation factor 11 Human genes 0.000 claims description 69
- 101000893545 Homo sapiens Growth/differentiation factor 11 Proteins 0.000 claims description 68
- 102100039939 Growth/differentiation factor 8 Human genes 0.000 claims description 61
- 108010023082 activin A Proteins 0.000 claims description 61
- 101000886562 Homo sapiens Growth/differentiation factor 8 Proteins 0.000 claims description 59
- 239000011230 binding agent Substances 0.000 claims description 52
- 108020001507 fusion proteins Proteins 0.000 claims description 52
- 102000037865 fusion proteins Human genes 0.000 claims description 52
- 239000000833 heterodimer Substances 0.000 claims description 46
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 45
- 230000002378 acidificating effect Effects 0.000 claims description 41
- 108010023079 activin B Proteins 0.000 claims description 41
- 108010021064 CTLA-4 Antigen Proteins 0.000 claims description 39
- 102000008203 CTLA-4 Antigen Human genes 0.000 claims description 39
- 102100040892 Growth/differentiation factor 2 Human genes 0.000 claims description 38
- 101000893585 Homo sapiens Growth/differentiation factor 2 Proteins 0.000 claims description 38
- 206010062016 Immunosuppression Diseases 0.000 claims description 38
- 230000001506 immunosuppresive effect Effects 0.000 claims description 38
- 229960005486 vaccine Drugs 0.000 claims description 38
- 102100028726 Bone morphogenetic protein 10 Human genes 0.000 claims description 37
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims description 37
- 101000695367 Homo sapiens Bone morphogenetic protein 10 Proteins 0.000 claims description 37
- 101000899390 Homo sapiens Bone morphogenetic protein 6 Proteins 0.000 claims description 37
- 238000009169 immunotherapy Methods 0.000 claims description 37
- 210000002865 immune cell Anatomy 0.000 claims description 36
- 102100035364 Growth/differentiation factor 3 Human genes 0.000 claims description 35
- 101001023986 Homo sapiens Growth/differentiation factor 3 Proteins 0.000 claims description 35
- 210000004027 cell Anatomy 0.000 claims description 33
- 206010009944 Colon cancer Diseases 0.000 claims description 30
- 206010027406 Mesothelioma Diseases 0.000 claims description 30
- 206010039491 Sarcoma Diseases 0.000 claims description 30
- 230000001394 metastastic effect Effects 0.000 claims description 30
- 206010061289 metastatic neoplasm Diseases 0.000 claims description 30
- 239000013543 active substance Substances 0.000 claims description 29
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 28
- 238000009098 adjuvant therapy Methods 0.000 claims description 27
- 201000010099 disease Diseases 0.000 claims description 26
- 229940045207 immuno-oncology agent Drugs 0.000 claims description 26
- 239000002584 immunological anticancer agent Substances 0.000 claims description 26
- 210000000056 organ Anatomy 0.000 claims description 26
- 230000034994 death Effects 0.000 claims description 25
- 206010061535 Ovarian neoplasm Diseases 0.000 claims description 23
- 230000003993 interaction Effects 0.000 claims description 20
- 238000006206 glycosylation reaction Methods 0.000 claims description 19
- 230000013595 glycosylation Effects 0.000 claims description 18
- 206010027476 Metastases Diseases 0.000 claims description 17
- 201000001441 melanoma Diseases 0.000 claims description 17
- 230000009401 metastasis Effects 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 16
- 208000006265 Renal cell carcinoma Diseases 0.000 claims description 16
- 230000002708 enhancing effect Effects 0.000 claims description 16
- 201000005202 lung cancer Diseases 0.000 claims description 16
- 208000020816 lung neoplasm Diseases 0.000 claims description 16
- 206010005003 Bladder cancer Diseases 0.000 claims description 15
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 15
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 15
- 206010025323 Lymphomas Diseases 0.000 claims description 15
- 206010027480 Metastatic malignant melanoma Diseases 0.000 claims description 15
- 208000034578 Multiple myelomas Diseases 0.000 claims description 15
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims description 15
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 15
- 206010033128 Ovarian cancer Diseases 0.000 claims description 15
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 15
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 15
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 15
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 15
- 201000010881 cervical cancer Diseases 0.000 claims description 15
- 208000029742 colonic neoplasm Diseases 0.000 claims description 15
- 201000004101 esophageal cancer Diseases 0.000 claims description 15
- 206010017758 gastric cancer Diseases 0.000 claims description 15
- 201000010536 head and neck cancer Diseases 0.000 claims description 15
- 208000014829 head and neck neoplasm Diseases 0.000 claims description 15
- 208000032839 leukemia Diseases 0.000 claims description 15
- 201000007270 liver cancer Diseases 0.000 claims description 15
- 208000014018 liver neoplasm Diseases 0.000 claims description 15
- 208000021039 metastatic melanoma Diseases 0.000 claims description 15
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 15
- 201000011549 stomach cancer Diseases 0.000 claims description 15
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 15
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 15
- 206010006187 Breast cancer Diseases 0.000 claims description 14
- 208000026310 Breast neoplasm Diseases 0.000 claims description 14
- 108060003951 Immunoglobulin Proteins 0.000 claims description 14
- 102000018358 immunoglobulin Human genes 0.000 claims description 14
- 229960005386 ipilimumab Drugs 0.000 claims description 14
- 208000023275 Autoimmune disease Diseases 0.000 claims description 13
- 230000001461 cytolytic effect Effects 0.000 claims description 13
- 229960002621 pembrolizumab Drugs 0.000 claims description 13
- 208000005017 glioblastoma Diseases 0.000 claims description 12
- 230000003071 parasitic effect Effects 0.000 claims description 12
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 11
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 11
- 230000004048 modification Effects 0.000 claims description 11
- 238000012986 modification Methods 0.000 claims description 11
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims description 10
- 230000001939 inductive effect Effects 0.000 claims description 10
- 210000004881 tumor cell Anatomy 0.000 claims description 10
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims description 9
- 230000005907 cancer growth Effects 0.000 claims description 9
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims description 9
- 241000700605 Viruses Species 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 6
- 102100033663 Transforming growth factor beta receptor type 3 Human genes 0.000 claims description 6
- 108010079292 betaglycan Proteins 0.000 claims description 6
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 6
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 6
- 208000017572 squamous cell neoplasm Diseases 0.000 claims description 6
- 244000052616 bacterial pathogen Species 0.000 claims description 5
- 244000053095 fungal pathogen Species 0.000 claims description 5
- 244000052613 viral pathogen Species 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims description 3
- 108091006020 Fc-tagged proteins Proteins 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 claims description 2
- 238000010200 validation analysis Methods 0.000 claims description 2
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 claims 26
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims 3
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims 3
- 125000003473 lipid group Chemical group 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 1
- 241000233866 Fungi Species 0.000 claims 1
- 210000000481 breast Anatomy 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 230000001965 increasing effect Effects 0.000 abstract description 17
- 108010057453 activin receptor type II-B Proteins 0.000 description 293
- 235000001014 amino acid Nutrition 0.000 description 173
- 102100027647 Activin receptor type-2B Human genes 0.000 description 172
- 229940024606 amino acid Drugs 0.000 description 160
- 108010057429 activin receptor type II-A Proteins 0.000 description 78
- 102100021886 Activin receptor type-2A Human genes 0.000 description 51
- 108090000623 proteins and genes Proteins 0.000 description 51
- 230000000694 effects Effects 0.000 description 49
- 102000004169 proteins and genes Human genes 0.000 description 48
- 235000018102 proteins Nutrition 0.000 description 47
- 102000005962 receptors Human genes 0.000 description 39
- 108020003175 receptors Proteins 0.000 description 39
- 241000282414 Homo sapiens Species 0.000 description 34
- 150000007523 nucleic acids Chemical class 0.000 description 33
- 210000001519 tissue Anatomy 0.000 description 29
- 238000006467 substitution reaction Methods 0.000 description 26
- 108020001756 ligand binding domains Proteins 0.000 description 24
- 239000002773 nucleotide Substances 0.000 description 22
- 125000003729 nucleotide group Chemical group 0.000 description 22
- 230000035772 mutation Effects 0.000 description 21
- 230000011664 signaling Effects 0.000 description 21
- 238000003556 assay Methods 0.000 description 20
- 239000000126 substance Substances 0.000 description 20
- 125000000539 amino acid group Chemical group 0.000 description 18
- 239000003795 chemical substances by application Substances 0.000 description 18
- 239000002243 precursor Substances 0.000 description 18
- 108010029485 Protein Isoforms Proteins 0.000 description 17
- 102000001708 Protein Isoforms Human genes 0.000 description 17
- 239000003112 inhibitor Substances 0.000 description 17
- 230000005764 inhibitory process Effects 0.000 description 16
- 235000018417 cysteine Nutrition 0.000 description 15
- 230000004927 fusion Effects 0.000 description 14
- 208000015181 infectious disease Diseases 0.000 description 14
- 241000251539 Vertebrata <Metazoa> Species 0.000 description 13
- 239000007788 liquid Substances 0.000 description 13
- 101000970954 Homo sapiens Activin receptor type-2A Proteins 0.000 description 12
- 239000000710 homodimer Substances 0.000 description 12
- 230000002401 inhibitory effect Effects 0.000 description 12
- 125000005647 linker group Chemical group 0.000 description 12
- 101000937269 Homo sapiens Activin receptor type-2B Proteins 0.000 description 11
- 108010076504 Protein Sorting Signals Proteins 0.000 description 11
- 102000049307 human ACVR1B Human genes 0.000 description 11
- 102000045412 human ACVR2B Human genes 0.000 description 11
- 102220479051 CD59 glycoprotein_L79D_mutation Human genes 0.000 description 10
- 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 10
- 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 10
- 210000004899 c-terminal region Anatomy 0.000 description 10
- 238000000423 cell based assay Methods 0.000 description 10
- 229960000187 tissue plasminogen activator Drugs 0.000 description 10
- 208000035473 Communicable disease Diseases 0.000 description 9
- 108091028043 Nucleic acid sequence Proteins 0.000 description 9
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 9
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 description 9
- 230000007783 downstream signaling Effects 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 241000894007 species Species 0.000 description 9
- 238000012217 deletion Methods 0.000 description 8
- 230000037430 deletion Effects 0.000 description 8
- 230000003053 immunization Effects 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 230000004614 tumor growth Effects 0.000 description 8
- 241000287828 Gallus gallus Species 0.000 description 7
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 7
- 241000269370 Xenopus <genus> Species 0.000 description 7
- 239000000539 dimer Substances 0.000 description 7
- 239000012634 fragment Substances 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000007474 Multiprotein Complexes Human genes 0.000 description 6
- 108010085220 Multiprotein Complexes Proteins 0.000 description 6
- 230000001580 bacterial effect Effects 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 230000002538 fungal effect Effects 0.000 description 6
- 230000014509 gene expression Effects 0.000 description 6
- 238000003780 insertion Methods 0.000 description 6
- 230000037431 insertion Effects 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 229910052700 potassium Inorganic materials 0.000 description 6
- 150000003384 small molecules Chemical class 0.000 description 6
- 235000000346 sugar Nutrition 0.000 description 6
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 5
- -1 ALK5 Proteins 0.000 description 5
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 5
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 5
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 5
- 102100035368 Growth/differentiation factor 6 Human genes 0.000 description 5
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 description 5
- 101001023964 Homo sapiens Growth/differentiation factor 6 Proteins 0.000 description 5
- 230000004988 N-glycosylation Effects 0.000 description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 5
- 239000004473 Threonine Substances 0.000 description 5
- 238000007792 addition Methods 0.000 description 5
- 230000004075 alteration Effects 0.000 description 5
- 229940028334 follicle stimulating hormone Drugs 0.000 description 5
- 229930195712 glutamate Natural products 0.000 description 5
- 210000003128 head Anatomy 0.000 description 5
- 125000001165 hydrophobic group Chemical group 0.000 description 5
- 210000000987 immune system Anatomy 0.000 description 5
- 230000001404 mediated effect Effects 0.000 description 5
- 239000000178 monomer Substances 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 5
- 102000040430 polynucleotide Human genes 0.000 description 5
- 108091033319 polynucleotide Proteins 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 230000028327 secretion Effects 0.000 description 5
- 230000019491 signal transduction Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 102000035160 transmembrane proteins Human genes 0.000 description 5
- 108091005703 transmembrane proteins Proteins 0.000 description 5
- 239000004475 Arginine Substances 0.000 description 4
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 4
- 102100022544 Bone morphogenetic protein 7 Human genes 0.000 description 4
- 201000009030 Carcinoma Diseases 0.000 description 4
- 102100029379 Follistatin-related protein 3 Human genes 0.000 description 4
- 206010018338 Glioma Diseases 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 102100035379 Growth/differentiation factor 5 Human genes 0.000 description 4
- 102100035363 Growth/differentiation factor 7 Human genes 0.000 description 4
- 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 4
- 101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 description 4
- 101001023988 Homo sapiens Growth/differentiation factor 5 Proteins 0.000 description 4
- 101001023968 Homo sapiens Growth/differentiation factor 7 Proteins 0.000 description 4
- 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 4
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 4
- 125000000729 N-terminal amino-acid group Chemical group 0.000 description 4
- 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 4
- 102000007374 Smad Proteins Human genes 0.000 description 4
- 108010007945 Smad Proteins Proteins 0.000 description 4
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 4
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 4
- 235000004279 alanine Nutrition 0.000 description 4
- 230000008485 antagonism Effects 0.000 description 4
- 230000000259 anti-tumor effect Effects 0.000 description 4
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 4
- 229940009098 aspartate Drugs 0.000 description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-L aspartate group Chemical group N[C@@H](CC(=O)[O-])C(=O)[O-] CKLJMWTZIZZHCS-REOHCLBHSA-L 0.000 description 4
- 238000009566 cancer vaccine Methods 0.000 description 4
- 229940022399 cancer vaccine Drugs 0.000 description 4
- 230000001086 cytosolic effect Effects 0.000 description 4
- 239000003623 enhancer Substances 0.000 description 4
- 210000003494 hepatocyte Anatomy 0.000 description 4
- 230000002209 hydrophobic effect Effects 0.000 description 4
- 238000002649 immunization Methods 0.000 description 4
- 229960000310 isoleucine Drugs 0.000 description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 4
- 238000002887 multiple sequence alignment Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 238000012163 sequencing technique Methods 0.000 description 4
- 150000008163 sugars Chemical class 0.000 description 4
- 239000004474 valine Substances 0.000 description 4
- UBWXUGDQUBIEIZ-UHFFFAOYSA-N (13-methyl-3-oxo-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-17-yl) 3-phenylpropanoate Chemical compound CC12CCC(C3CCC(=O)C=C3CC3)C3C1CCC2OC(=O)CCC1=CC=CC=C1 UBWXUGDQUBIEIZ-UHFFFAOYSA-N 0.000 description 3
- 102000005606 Activins Human genes 0.000 description 3
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 description 3
- 102100022526 Bone morphogenetic protein 5 Human genes 0.000 description 3
- 101000724917 Calliophis bivirgatus Delta-elapitoxin-Cb1a Proteins 0.000 description 3
- 101000724912 Calliophis bivirgatus Maticotoxin A Proteins 0.000 description 3
- 101000724921 Dendroaspis polylepis polylepis Dendroaspis polylepis MT9 Proteins 0.000 description 3
- 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 3
- 101000762375 Homo sapiens Bone morphogenetic protein 3 Proteins 0.000 description 3
- 101000899388 Homo sapiens Bone morphogenetic protein 5 Proteins 0.000 description 3
- 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 3
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 3
- 101000783591 Micrurus clarki Clarkitoxin-1 Proteins 0.000 description 3
- 101000963932 Micrurus frontalis Frontoxin II Proteins 0.000 description 3
- 101000783588 Micrurus mipartitus Mipartoxin-1 Proteins 0.000 description 3
- 101000963935 Micrurus nigrocinctus Nicotinic acetylcholine receptor-binding protein Mnn-1A Proteins 0.000 description 3
- 101000964147 Micrurus nigrocinctus Nicotinic acetylcholine receptor-binding protein Mnn-3C Proteins 0.000 description 3
- 101000964140 Micrurus nigrocinctus Nicotinic acetylcholine receptor-binding protein Mnn-4 Proteins 0.000 description 3
- 101000724922 Micrurus pyrrhocryptus Venom protein E2 Proteins 0.000 description 3
- 101000724923 Micrurus surinamensis Short neurotoxin MS11 Proteins 0.000 description 3
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 101000724924 Naja kaouthia Nakoroxin Proteins 0.000 description 3
- 101000963934 Ophiophagus hannah Neurotoxin Oh9-1 Proteins 0.000 description 3
- 101000724920 Ophiophagus hannah Short neurotoxin OH-26 Proteins 0.000 description 3
- 101000963927 Ophiophagus hannah Short neurotoxin OH-32 Proteins 0.000 description 3
- 101000724910 Ophiophagus hannah Short neurotoxin OH-46 Proteins 0.000 description 3
- 101000964138 Ophiophagus hannah Short neurotoxin OH-5 Proteins 0.000 description 3
- 101000724915 Ophiophagus hannah Short neurotoxin SNTX11 Proteins 0.000 description 3
- 101000724916 Ophiophagus hannah Short neurotoxin SNTX14 Proteins 0.000 description 3
- 101000724918 Ophiophagus hannah Short neurotoxin SNTX26 Proteins 0.000 description 3
- 101000724908 Ophiophagus hannah Short neurotoxin SNTX6 Proteins 0.000 description 3
- 101000964146 Ophiophagus hannah Weak neurotoxin WNTX33 Proteins 0.000 description 3
- 101000964133 Oxyuranus microlepidotus Toxin 3FTx-Oxy5 Proteins 0.000 description 3
- 101000724919 Oxyuranus scutellatus scutellatus Scutelatoxin Proteins 0.000 description 3
- 101000964145 Oxyuranus scutellatus scutellatus Short neurotoxin 3 Proteins 0.000 description 3
- 102220542870 Presenilins-associated rhomboid-like protein, mitochondrial_L79E_mutation Human genes 0.000 description 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 3
- 238000013459 approach Methods 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 238000002619 cancer immunotherapy Methods 0.000 description 3
- 150000001720 carbohydrates Chemical group 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000018109 developmental process Effects 0.000 description 3
- 230000004069 differentiation Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229920001519 homopolymer Polymers 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 230000003834 intracellular effect Effects 0.000 description 3
- 230000000670 limiting effect Effects 0.000 description 3
- 210000004962 mammalian cell Anatomy 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 230000004083 survival effect Effects 0.000 description 3
- 230000008685 targeting Effects 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- CJLHTKGWEUGORV-UHFFFAOYSA-N Artemin Chemical compound C1CC2(C)C(O)CCC(=C)C2(O)C2C1C(C)C(=O)O2 CJLHTKGWEUGORV-UHFFFAOYSA-N 0.000 description 2
- 102220638160 Arylamine N-acetyltransferase 1_R64K_mutation Human genes 0.000 description 2
- 102100028727 Bone morphogenetic protein 15 Human genes 0.000 description 2
- 229940045513 CTLA4 antagonist Drugs 0.000 description 2
- 102220578645 Chorion-specific transcription factor GCMb_N65A_mutation Human genes 0.000 description 2
- 108091033380 Coding strand Proteins 0.000 description 2
- 102220525561 Coiled-coil domain-containing protein 200_A24N_mutation Human genes 0.000 description 2
- 102000004127 Cytokines Human genes 0.000 description 2
- 108090000695 Cytokines Proteins 0.000 description 2
- 102100040897 Embryonic growth/differentiation factor 1 Human genes 0.000 description 2
- 108010012820 Follistatin-Related Proteins Proteins 0.000 description 2
- 102000034615 Glial cell line-derived neurotrophic factor Human genes 0.000 description 2
- 108091010837 Glial cell line-derived neurotrophic factor Proteins 0.000 description 2
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 2
- 108010031186 Glycoside Hydrolases Proteins 0.000 description 2
- 102000005744 Glycoside Hydrolases Human genes 0.000 description 2
- 102100035970 Growth/differentiation factor 9 Human genes 0.000 description 2
- 241000238631 Hexapoda Species 0.000 description 2
- 101000695360 Homo sapiens Bone morphogenetic protein 15 Proteins 0.000 description 2
- 101000893552 Homo sapiens Embryonic growth/differentiation factor 1 Proteins 0.000 description 2
- 101001062529 Homo sapiens Follistatin-related protein 3 Proteins 0.000 description 2
- 101001075110 Homo sapiens Growth/differentiation factor 9 Proteins 0.000 description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 2
- 108010056852 Myostatin Proteins 0.000 description 2
- 241000287143 Myotis davidii Species 0.000 description 2
- 101000937265 Ovis aries Activin receptor type-2A Proteins 0.000 description 2
- 206010038389 Renal cancer Diseases 0.000 description 2
- 108091081021 Sense strand Proteins 0.000 description 2
- 102000043168 TGF-beta family Human genes 0.000 description 2
- 108091085018 TGF-beta family Proteins 0.000 description 2
- 241000566589 Tyto alba Species 0.000 description 2
- PNVLWFYAPWAQMU-CIUDSAMLSA-N Val-Ile Chemical group CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](N)C(C)C PNVLWFYAPWAQMU-CIUDSAMLSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000003042 antagnostic effect Effects 0.000 description 2
- 239000000868 anti-mullerian hormone Substances 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 2
- 229960001230 asparagine Drugs 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 238000003776 cleavage reaction Methods 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 238000004590 computer program Methods 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000003937 drug carrier Substances 0.000 description 2
- 235000013922 glutamic acid Nutrition 0.000 description 2
- 239000004220 glutamic acid Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 231100000086 high toxicity Toxicity 0.000 description 2
- 230000008629 immune suppression Effects 0.000 description 2
- 239000002955 immunomodulating agent Substances 0.000 description 2
- 230000001976 improved effect Effects 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 239000000893 inhibin Substances 0.000 description 2
- ZPNFWUPYTFPOJU-LPYSRVMUSA-N iniprol Chemical compound C([C@H]1C(=O)NCC(=O)NCC(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H](C(N[C@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC=4C=CC=CC=4)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC=4C=CC=CC=4)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC2=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H]2N(CCC2)C(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N2[C@@H](CCC2)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N3)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@H](C(=O)N1)C(C)C)[C@@H](C)O)[C@@H](C)CC)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 ZPNFWUPYTFPOJU-LPYSRVMUSA-N 0.000 description 2
- 230000004068 intracellular signaling Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 108010004165 polystatin Proteins 0.000 description 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002510 pyrogen Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000001850 reproductive effect Effects 0.000 description 2
- 230000007017 scission Effects 0.000 description 2
- 210000002966 serum Anatomy 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 125000000341 threoninyl group Chemical class [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 2
- 101710173011 Activin receptor type-1B Proteins 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 102100026376 Artemin Human genes 0.000 description 1
- 101710205806 Artemin Proteins 0.000 description 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- 244000186140 Asperula odorata Species 0.000 description 1
- 102100022545 Bone morphogenetic protein 8B Human genes 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 101000970957 Bos taurus Activin receptor type-2A Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 102220578642 Chorion-specific transcription factor GCMb_K74M_mutation Human genes 0.000 description 1
- 241001282194 Condylura cristata Species 0.000 description 1
- 108091035707 Consensus sequence Proteins 0.000 description 1
- 102220575187 Egl nine homolog 1_F82A_mutation Human genes 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000289669 Erinaceus europaeus Species 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 235000008526 Galium odoratum Nutrition 0.000 description 1
- 102000005720 Glutathione transferase Human genes 0.000 description 1
- 108010070675 Glutathione transferase Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102100040895 Growth/differentiation factor 10 Human genes 0.000 description 1
- 101710194452 Growth/differentiation factor 11 Proteins 0.000 description 1
- 101000799193 Homo sapiens Activin receptor type-1C Proteins 0.000 description 1
- 101000899368 Homo sapiens Bone morphogenetic protein 8B Proteins 0.000 description 1
- 101000893563 Homo sapiens Growth/differentiation factor 10 Proteins 0.000 description 1
- 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 1
- 101000692878 Homo sapiens Regulator of MON1-CCZ1 complex Proteins 0.000 description 1
- 101000712669 Homo sapiens TGF-beta receptor type-2 Proteins 0.000 description 1
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- 206010062767 Hypophysitis Diseases 0.000 description 1
- 108091092195 Intron Proteins 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 101100490437 Mus musculus Acvrl1 gene Proteins 0.000 description 1
- 101100175313 Mus musculus Gdf3 gene Proteins 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 230000004989 O-glycosylation Effects 0.000 description 1
- 239000004235 Orange GGN Substances 0.000 description 1
- 102220567352 Ornithine decarboxylase antizyme 1_K74F_mutation Human genes 0.000 description 1
- 102220633854 PRKCA-binding protein_D80A_mutation Human genes 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 102220496976 Platelet-activating factor acetylhydrolase 2, cytoplasmic_L79A_mutation Human genes 0.000 description 1
- 102220577876 Poly(rC)-binding protein 1_W78A_mutation Human genes 0.000 description 1
- 102220469872 Protein argonaute-3_E37A_mutation Human genes 0.000 description 1
- 102220495689 Putative uncharacterized protein FLJ43944_R40A_mutation Human genes 0.000 description 1
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 102220495911 Serine-tRNA ligase, cytoplasmic_K55A_mutation Human genes 0.000 description 1
- 102220577404 Signal transducer CD24_S44T_mutation Human genes 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102000007453 TGF-beta Superfamily Proteins Human genes 0.000 description 1
- 108010085004 TGF-beta Superfamily Proteins Proteins 0.000 description 1
- 102000040945 Transcription factor Human genes 0.000 description 1
- 108091023040 Transcription factor Proteins 0.000 description 1
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 description 1
- 102000000523 Type II Activin Receptors Human genes 0.000 description 1
- 108010041546 Type II Activin Receptors Proteins 0.000 description 1
- 102220469729 Voltage-dependent L-type calcium channel subunit beta-2_D54K_mutation Human genes 0.000 description 1
- 102220479829 Voltage-dependent L-type calcium channel subunit beta-2_R56K_mutation Human genes 0.000 description 1
- XEKVBIXIBCYLRT-RSAXXLAASA-N [4-[(2e)-2-[3-[(2s)-2-amino-2-carboxyethyl]-6-oxocyclohexa-2,4-dien-1-ylidene]hydrazinyl]phenyl]-trimethylazanium;chloride Chemical compound [Cl-].C1=CC([N+](C)(C)C)=CC=C1N\N=C/1C(=O)C=CC(C[C@H](N)C(O)=O)=C\1 XEKVBIXIBCYLRT-RSAXXLAASA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003044 adaptive effect Effects 0.000 description 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 1
- 125000003368 amide group Chemical group 0.000 description 1
- 230000006229 amino acid addition Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000006023 anti-tumor response Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000003443 antiviral agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000009582 asparagine Nutrition 0.000 description 1
- 210000001130 astrocyte Anatomy 0.000 description 1
- 230000001363 autoimmune Effects 0.000 description 1
- 108091008324 binding proteins Proteins 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000004422 calculation algorithm Methods 0.000 description 1
- 238000011965 cell line development Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000003340 combinatorial analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 230000002860 competitive effect Effects 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000022811 deglycosylation Effects 0.000 description 1
- 230000002939 deleterious effect Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 230000000235 effect on cancer Effects 0.000 description 1
- 230000002900 effect on cell Effects 0.000 description 1
- 239000012636 effector Substances 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 210000002889 endothelial cell Anatomy 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229960002591 hydroxyproline Drugs 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 230000001024 immunotherapeutic effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 125000000741 isoleucyl group Chemical group [H]N([H])C(C(C([H])([H])[H])C([H])([H])C([H])([H])[H])C(=O)O* 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 150000002614 leucines Chemical class 0.000 description 1
- 150000002632 lipids Chemical group 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 201000005249 lung adenocarcinoma Diseases 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 230000000877 morphologic effect Effects 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 229950006780 n-acetylglucosamine Drugs 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
- 230000006576 neuronal survival Effects 0.000 description 1
- 230000025342 organ morphogenesis Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 230000000865 phosphorylative effect Effects 0.000 description 1
- 210000003635 pituitary gland Anatomy 0.000 description 1
- 230000003169 placental effect Effects 0.000 description 1
- 229920002704 polyhistidine Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 210000004986 primary T-cell Anatomy 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000017854 proteolysis Effects 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 208000016691 refractory malignant neoplasm Diseases 0.000 description 1
- 201000010174 renal carcinoma Diseases 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
- 102220125997 rs141863326 Human genes 0.000 description 1
- 102220288227 rs141863326 Human genes 0.000 description 1
- 102200145357 rs1555341957 Human genes 0.000 description 1
- 102220036189 rs273585616 Human genes 0.000 description 1
- 102220005147 rs34173382 Human genes 0.000 description 1
- 102200158858 rs34435255 Human genes 0.000 description 1
- 102200089383 rs57977969 Human genes 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 210000000130 stem cell Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000009120 supportive therapy Methods 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000002626 targeted therapy Methods 0.000 description 1
- 230000030968 tissue homeostasis Effects 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/495—Transforming growth factor [TGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/1103—Receptor protein serine/threonine kinase (2.7.11.30)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762453413P | 2017-02-01 | 2017-02-01 | |
| US62/453,413 | 2017-02-01 | ||
| PCT/US2018/016148 WO2018144542A1 (en) | 2017-02-01 | 2018-01-31 | TGFβ AND ACTRII ANTAGONISTS FOR USE IN INCREASING IMMUNE ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190115037A true KR20190115037A (ko) | 2019-10-10 |
Family
ID=63041217
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197025689A Ceased KR20190115037A (ko) | 2017-02-01 | 2018-01-31 | 면역 활성을 증가시키는데 이용되는 TGFβ 및 ActRII |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20200306340A1 (enExample) |
| EP (1) | EP3576773B1 (enExample) |
| JP (2) | JP7246617B2 (enExample) |
| KR (1) | KR20190115037A (enExample) |
| CN (1) | CN110494155A (enExample) |
| AU (1) | AU2018214979A1 (enExample) |
| CA (1) | CA3051696A1 (enExample) |
| WO (1) | WO2018144542A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7051846B2 (ja) | 2016-11-10 | 2022-04-11 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| JP7258021B2 (ja) | 2017-11-09 | 2023-04-14 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体を含む医薬組成物 |
| KR20200109330A (ko) | 2018-01-12 | 2020-09-22 | 케로스 테라퓨틱스, 인크. | 액티빈 수용체 유형 iib 변이체 및 그의 사용 방법 |
| CA3098679A1 (en) | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
| EP3807308A4 (en) * | 2018-06-15 | 2022-03-16 | Acceleron Pharma Inc. | BI AND TRIFUNCTIONAL FUSION PROTEINS AND THEIR USES |
| WO2021189010A1 (en) | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iib variants |
| WO2022063114A1 (zh) * | 2020-09-23 | 2022-03-31 | 海正生物制药有限公司 | Tgfbr2-ecd突变体及包含其的融合蛋白与应用 |
| JP2023548399A (ja) * | 2020-11-04 | 2023-11-16 | ハン，ハック | Ｔｇｆ－ベータファミリーの複数のリガンドを阻害する能力を有する新規の二機能性多特異性アンタゴニストおよびその使用 |
| CN118109416B (zh) * | 2023-03-30 | 2024-11-22 | 广州百吉生物制药有限公司 | 功能增强型工程化免疫细胞及其制备和应用 |
| CN117721131A (zh) * | 2023-12-19 | 2024-03-19 | 吉林大学 | 一种重组骨形态发生蛋白突变体的制备方法和应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1486560A3 (en) * | 1999-04-30 | 2005-02-09 | Cambridge Antibody Technology LTD | Specific antibodies and antibody fragments for TGFBETA1 |
| GB0209893D0 (en) * | 2002-04-30 | 2002-06-05 | Molmed Spa | Conjugate |
| ES2547958T3 (es) * | 2006-12-20 | 2015-10-09 | Novarx | Vacuna de célula tumoral universal para utilización terapéutica y profiláctica anticancerígena |
| MX354099B (es) * | 2007-02-01 | 2018-02-13 | Acceleron Pharma Inc | Antagonistas de activina-actriia y usos para tratar o prevenir cancer de mama. |
| TWI432449B (zh) * | 2007-02-02 | 2014-04-01 | Acceleron Pharma Inc | 衍生自ＡｃｔＲＩＩＢ的變體與其用途 |
| KR20160129095A (ko) * | 2007-02-09 | 2016-11-08 | 악셀레론 파마 인코포레이티드 | 액티빈-ＡｃｔＲⅡＡ 길항제 및 암 환자에서 골 생장을 촉진시키기 위한 이의 용도 |
| CN101780272B (zh) * | 2009-12-24 | 2012-01-25 | 湖南农业大学 | 一种含有TGF β1自体疫苗制剂的应用 |
| IL323000A (en) * | 2010-03-05 | 2025-10-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeted for immune modulation |
| HRP20211582T1 (hr) * | 2011-06-03 | 2022-01-07 | Xoma Technology Ltd. | Protutijela specifična za tgf-beta |
| MA41916A (fr) | 2015-04-06 | 2021-04-14 | Acceleron Pharma Inc | Hétéromultimères de récepteur de type i et de type ii de la superfamille de tgf-bêta et leurs utilisations |
| AU2016246602B2 (en) * | 2015-04-06 | 2020-11-19 | Acceleron Pharma Inc. | Single-arm type I and type II receptor fusion proteins and uses thereof |
| EP3307772B1 (en) * | 2015-06-12 | 2020-09-09 | Ludwig Institute For Cancer Research Limited | Tgf-beta 3 specific antibodies and methods and uses thereof |
| EP3420002A4 (en) * | 2016-02-22 | 2020-01-15 | Acceleron Pharma Inc. | ACTRII ANTAGONISTS FOR USE TO INCREASE IMMUNITY |
-
2018
- 2018-01-31 CN CN201880023489.0A patent/CN110494155A/zh active Pending
- 2018-01-31 US US16/482,869 patent/US20200306340A1/en not_active Abandoned
- 2018-01-31 JP JP2019562229A patent/JP7246617B2/ja active Active
- 2018-01-31 WO PCT/US2018/016148 patent/WO2018144542A1/en not_active Ceased
- 2018-01-31 CA CA3051696A patent/CA3051696A1/en active Pending
- 2018-01-31 EP EP18747362.4A patent/EP3576773B1/en active Active
- 2018-01-31 KR KR1020197025689A patent/KR20190115037A/ko not_active Ceased
- 2018-01-31 AU AU2018214979A patent/AU2018214979A1/en not_active Abandoned
-
2022
- 2022-11-14 JP JP2022181719A patent/JP2023012552A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3576773A1 (en) | 2019-12-11 |
| US20200306340A1 (en) | 2020-10-01 |
| JP2023012552A (ja) | 2023-01-25 |
| JP2020505475A (ja) | 2020-02-20 |
| EP3576773A4 (en) | 2020-08-12 |
| AU2018214979A1 (en) | 2019-08-15 |
| WO2018144542A1 (en) | 2018-08-09 |
| CA3051696A1 (en) | 2018-08-09 |
| CN110494155A (zh) | 2019-11-22 |
| EP3576773B1 (en) | 2023-10-18 |
| JP7246617B2 (ja) | 2023-03-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12343378B2 (en) | Compositions and methods for treating pulmonary hypertension | |
| US20170240639A1 (en) | Actrii antagonists for use in increasing immune activity | |
| US20240189391A1 (en) | Compositions and methods for treating spinal muscular atrophy | |
| US20200306340A1 (en) | Tgfbeta and actrii antagonists for use in increasing immune activity | |
| US20220089683A1 (en) | Bi-and tri-functional fusion proteins and uses thereof | |
| BR122024015924A2 (pt) | Uso de um polipeptídeo para a preparação de um medicamento tratarhipertensão arterial pulmonar, hipertensão venosa pulmonar ou hipertensãopulmonar com doença pulmonar e/ou hipoxemia |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20190902 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20210129 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20221216 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20230613 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20221216 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |