KR20190099397A - 화합물의 생산을 위한 조성물 및 방법 - Google Patents
화합물의 생산을 위한 조성물 및 방법 Download PDFInfo
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Abstract
본 개시내용은 관심 화합물의 생산에 유용한 단백질, 핵산, 벡터 및 숙주 분자, 및 그의 사용 방법을 제공한다.
Description
폴리케티드 천연 생성물은 다른 조정 효소와 함께 폴리케티드 신타제 (PKS), 예를 들어, 유형 I 폴리케티드 신타제에 의해 생합성적으로 생산된다. 폴리케티드 신타제 (PKS)는 대형, 다중-도메인 단백질의 패밀리이며, 그의 촉매 기능은 폴리케티드를 생산하기 위해 모듈로 조직화된다. 폴리케티드 신타제 클러스터의 기본 기능적 단위는 모듈이며, 이는 예를 들어 말로닐-CoA로부터 유래된 2-탄소 연장기 단위를 코딩한다. 폴리케티드 신타제에 일반적으로 존재하는 모듈은 i) 로딩 모듈; ii) 연장 모듈; 및 iii) 방출 모듈을 포함한다. 모듈 내에서, 폴리케티드 쇄 연장 및 신장에 필요한 최소 도메인 아키텍처는 케토신타제 (KS), 아실-트랜스퍼라제 (AT) 및 ACP (아실-담체 단백질) 도메인을 포함하고, 각각의 모듈의 특이적 화학은 AT 도메인에 의해 및 β-케톤 프로세싱 도메인: 케토리덕타제 (KR), 데히드라타제 (DH), 및 에노일리덕타제 (ER) 도메인의 존재에 의해 코딩된다. 폴리케티드 신타제 생합성은 2가지 주요 메카니즘: 폴리케티드 신타제 연장 모듈에 의한 폴리케티드 쇄 신장 및 모듈 사이의 폴리케티드 중간체의 전위에 의해 진행된다. 생산적 쇄 신장은 모듈 내 및 모듈 사이 둘 다에서의 수많은 촉매 도메인의 협동 기능에 좌우된다.
조합 생합성은 신규 약물 후보를 생산하기 위해 폴리케티드 신타제 (PKS) 유전자 클러스터를 조작하는데 사용되어 온 일반적 전략이다 (Weissman and Leadlay, Nature Reviews Microbiology, 2005). 지금까지, 이들 전략은 모듈 내에서 PKS 도메인 결실 및/또는 도메인 스와프를 조작하는 것 또는 전체 모듈을 또 다른 클러스터로부터 스와핑하여 키메라 클러스터를 생산하는 것에 의존해왔다. 이러한 접근법의 문제점은 대대적인 도메인 및/또는 모듈 대체, 삽입, 또는 결실을 통한 폴리케티드 메가신타제의 단백질 조작이 PKS의 "조립 라인" 아키텍처를 교란시켜, 합성되는 폴리케티드의 양을 대폭 감소시킬 수 있다는 것이다.
본 개시내용은 폴리케티드 신타제 유전자 사이의 모듈 스와핑에 의해, 화합물 생산의 유의한 손실 없이 폴리케티드를 조합 생합성하는데 사용하기 위한 조성물 및 방법을 제공한다. 생물정보학 접근법은 모듈 인터페이스 상용성을 예측하고, 따라서 이종 모듈이 PKS 유전자 내로 스와핑될 수 있는 가능성을 예측하는데 사용될 수 있다. 생성된 상용성 정보는 조립-라인 폴리케티드 생합성에서 기능할 증가된 가능성을 갖는 폴리케티드 신타제를 조작하는데 사용될 수 있다.
따라서, 한 측면에서, 개시내용은 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제를 제공하며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 1개 이상의 이종 모듈은 폴리케티드 생합성 동안 폴리케티드 전위를 실질적으로 억제하지 않는다.
또 다른 측면에서, 개시내용은 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제를 제공하며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 1개 이상의 이종 모듈은 그에 인접한 모듈의 연결 서열에 상용성인 연결 서열을 포함한다.
또 다른 측면에서, 개시내용은 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제를 제공하며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 조작된 폴리케티드 신타제의 폴리케티드 발현 수준은 참조 폴리케티드 신타제의 폴리케티드 발현 수준의 적어도 1% (예를 들어, 적어도 1%, 적어도 2%, 적어도 3%, 적어도 4%, 적어도 5%, 적어도 6%, 적어도 7%, 적어도 8%, 적어도 9%, 적어도 10%, 적어도 20%, 적어도 30%, 적어도 40%, 적어도 50%, 적어도 60%, 적어도 70%, 적어도 80%, 적어도 90%, 적어도 100%, 적어도 110%, 적어도 120%, 적어도 130%, 적어도 140%, 적어도 150%)이다.
일부 실시양태에서, 조작된 폴리케티드 신타제의 폴리케티드 발현 수준은 적어도 1-10% (예를 들어 적어도 1-10%, 적어도 11-20%, 적어도 21-30%, 적어도 31-40%, 적어도 41-50%, 적어도 51-60%, 적어도 61-70%, 적어도 71-80%, 적어도 81-90%, 적어도 91-100%, 적어도 101-110%, 적어도 1111-120%, 적어도 121-130%, 적어도 131-140%, 적어도 141-150%)이다. 일부 실시양태에서, 조작된 폴리케티드 신타제는 천연 연결 서열에 의한 1개 이상의 이종 모듈을 포함한다.
일부 실시양태에서, 조작된 폴리케티드 신타제는 1, 2, 3개 또는 그 초과의 이종 모듈을 포함할 수 있다. 조작된 폴리케티드 신타제가 다중 이종 모듈을 함유하는 일부 실시양태에서, 이종 모듈은 조작된 폴리케티드 신타제 내에서 인접할 수 있다. 폴리케티드 신타제가 다중 이종 모듈을 함유하는 일부 실시양태에서, 모듈 중 임의의 것은 조작된 폴리케티드 신타제 내에서 1개 이상의 천연 모듈에 의해 분리될 수 있다.
상기 기재된 측면 중 임의의 것의 일부 실시양태에서, 1개 이상의 이종 모듈 중 적어도 1개는 폴리케티드의 가변 영역 내 β-카르보닐 단위를 변형시키는 신장 모듈이다.
상기 기재된 측면 중 임의의 것의 일부 실시양태에서, 1개 이상의 이종 모듈 중 적어도 1개는 서열식별번호(SEQ ID NO): 1-174 중 어느 하나에 대해 적어도 90% 동일성을 갖는 부분을 포함한다.
상기 기재된 측면 중 임의의 것의 일부 실시양태에서, 1개 이상의 이종 모듈 중 적어도 1개는 서열식별번호: 1-174 중 어느 하나의 서열을 갖는 부분을 포함한다.
또 다른 측면에서, 개시내용은 키메라 폴리케티드 신타제를 제공하며, 여기서 키메라 폴리케티드 신타제의 적어도 1개의 모듈은 서열식별번호: 175-176의 서열을 갖는 폴리케티드 신타제와 비교하여 변형되었다.
일부 실시양태에서, 개시내용은 적어도 1개의 모듈이 서열식별번호: 1-174 중 어느 하나에 대해 적어도 90% 동일성을 갖는 부분을 포함하는 것인 키메라 폴리케티드 신타제를 제공한다.
또 다른 측면에서, 개시내용은 상기 기재된 폴리케티드 신타제 중 어느 하나를 코딩하는 핵산을 제공한다.
상기 기재된 측면 중 임의의 것의 일부 실시양태에서, 상기 기재된 폴리케티드 신타제 중 어느 하나를 코딩하는 핵산은 LAL을 추가로 코딩하고, 여기서 LAL을 코딩하는 서열은 폴리케티드 신타제를 코딩하는 서열에 작동가능하게 연결된다.
일부 실시양태에서, LAL은 이종 LAL일 수 있다.
일부 실시양태에서, LAL은 서열식별번호: 177에 대해 적어도 80% (예를 들어, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 99%) 서열 동일성을 갖는 부분을 포함할 수 있다. 일부 실시양태에서, LAL은 서열식별번호: 177의 서열을 갖는 부분을 포함할 수 있다. 일부 실시양태에서, 개시내용은 LAL이 서열식별번호: 177의 서열을 갖는 것인 핵산을 제공한다. 일부 실시양태에서, LAL은 오픈 리딩 프레임 내 TTA 억제 코돈이 결여되어 있다.
상기 핵산 중 임의의 것의 일부 실시양태에서, 핵산은 LAL 결합 부위를 포함하고, 여기서 LAL 결합 부위를 코딩하는 서열은 폴리케티드 신타제를 코딩하는 서열에 작동가능하게 연결된다.
일부 실시양태에서, LAL 결합 부위는 서열식별번호: 178의 서열 (CTAGGGGGTTGC)에 대해 적어도 80% (예를 들어, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 99%) 서열 동일성을 갖는 부분을 포함한다. 일부 실시양태에서, LAL 결합 부위는 서열식별번호: 178의 서열 (CTAGGGGGTTGC)을 갖는 부분을 포함한다. 일부 실시양태에서, LAL 결합 부위는 서열식별번호: 178의 서열 (CTAGGGGGTTGC)을 갖는다. 상기 기재된 측면의 일부 실시양태에서, LAL 결합 부위는 서열식별번호: 179의 서열 (GGGGGT)을 갖는다.
상기 핵산 중 임의의 것의 일부 실시양태에서, LAL 결합 부위에 대한 LAL의 결합은 폴리케티드 신타제의 발현을 촉진한다.
상기 핵산 중 임의의 것의 일부 실시양태에서, 상기 기재된 폴리케티드 신타제 중 어느 하나를 코딩하는 핵산은 비리보솜 펩티드 신타제를 추가로 코딩한다.
상기 핵산 중 임의의 것의 일부 실시양태에서, 상기 기재된 폴리케티드 신타제 중 어느 하나를 코딩하는 핵산은 P450 효소를 추가로 코딩한다.
상기 핵산 중 임의의 것의 일부 실시양태에서, 상기 기재된 폴리케티드 및 제1 P450 효소 중 어느 하나를 코딩하는 핵산은 제2 P450 효소를 추가로 코딩한다.
또 다른 측면에서, 개시내용은 상기 핵산 중 임의의 것을 포함하는 발현 벡터를 제공한다. 일부 실시양태에서, 발현 벡터는 인공 염색체, 예를 들어, 박테리아 인공 염색체일 수 있다.
또 다른 측면에서, 개시내용은 상기 기재된 발현 벡터 중 임의의 것을 포함하는 숙주 세포를 제공한다.
또 다른 측면에서, 개시내용은 상기 폴리케티드 신타제 중 임의의 것을 포함하는 숙주 세포를 제공하며, 여기서 폴리케티드 신타제는 숙주 세포에 대해 이종이다.
상기 숙주 세포 중 임의의 것의 일부 실시양태에서, 숙주 세포는 자연적으로 LAL 및/또는 LAL 결합 부위가 결여되어 있다.
상기 숙주 세포 중 임의의 것의 일부 실시양태에서, 숙주 세포는 LAL 결합 부위에 결합할 수 있고 폴리케티드 신타제의 발현을 조절할 수 있는 LAL을 포함한다. 일부 실시양태에서, LAL 및/또는 LAL 결합 부위는 세포에 대해 이종일 수 있다. 일부 실시양태에서, 숙주 세포는 서열식별번호: 177의 서열에 대해 적어도 80% (예를 들어, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 99%) 서열 동일성을 갖는 부분을 갖는 LAL을 포함한다.
상기 숙주 세포 중 임의의 것의 일부 실시양태에서, 숙주 세포는 박테리아, 예를 들어 악티노박테리아, 예컨대 스트렙토미세스 암보파시엔스(Streptomyces ambofaciens), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 또는 스트렙토미세스 말라이옌시스(Streptomyces malayensis)로 이루어진 군으로부터 선택된 악티노박테리아이다. 숙주 세포가 악티노박테리아인 일부 실시양태에서, 악티노박테리아는 S1391, S1496, 또는 S2441이다.
상기 숙주 세포 중 임의의 것의 일부 실시양태에서, 숙주 세포는 폴리케티드 신타제의 발현을 증진시키도록 변형된다. 예를 들어, 숙주 세포는 (i) 화합물-생산 단백질을 발현하는 내인성 유전자 클러스터의 결실; (ii) 화합물-생산 단백질을 발현하는 이종 유전자 클러스터의 삽입; (iii) 항생제 챌린지에 대한 숙주 세포의 노출; 및/또는 (iv) 동종 프로모터와 비교하여 화합물 발현을 적어도 2배 증가시키는 이종 프로모터의 도입에 의해 화합물-생산 단백질의 발현을 증진시키도록 변형된다.
또 다른 측면에서, 개시내용은 적합한 조건 하에 상기 숙주 세포 중 임의의 것을 배양함으로써, 폴리케티드를 생산하는 방법을 제공한다.
또 다른 측면에서, 개시내용은 상기 폴리케티드 신타제 중 임의의 것을 발현하도록 조작된 숙주 세포를 폴리케티드 신타제가 폴리케티드를 생산하는데 적합한 조건 하에 배양함으로써, 폴리케티드를 생산하는 방법을 제공한다.
또 다른 측면에서, 개시내용은 (a) 화합물을 생산할 수 있는 모 폴리케티드 신타제 서열을 제공하는 단계; (b) 제2 폴리케티드 신타제의 적어도 1개의 모듈과 모 폴리케티드 신타제의 적어도 2개의 모듈과의 상용성을 결정하는 단계; (c) 변형된 폴리케티드 신타제를 코딩하는 핵산을 생산하는 단계이며, 여기서 변형된 폴리케티드 신타제는 모 폴리케티드 신타제의 적어도 2개의 모듈과 상용성인 것으로 결정된 제2 폴리케티드 신타제의 적어도 1개의 모듈을 포함하는 것인 단계를 포함하는, 화합물을 생산하는 방법을 제공한다.
또 다른 측면에서, 개시내용은 (a) 모 폴리케티드 신타제를 코딩하는 모 핵산을 제공하는 단계; (b) 모 핵산을 변형시켜 화합물을 생산할 수 있는 변형된 폴리케티드 신타제를 코딩하는 변형된 핵산을 생성하는 단계이며, 여기서 변형은 적어도 1개의 이종 모듈을 포함하는 변형된 폴리케티드 신타제를 생산하는 것인 단계를 포함하는, 화합물을 생산하는 방법을 제공한다.
또 다른 측면에서, 개시내용은 (a) 화합물을 생산할 수 있는 모 폴리뉴클레오티드 서열을 제공하는 단계; (b) 모 폴리뉴클레오티드 서열 내 1개 이상의 모듈의 대체에 적합한 1개 이상의 이종 모듈을 확인하는 단계; (c) 변형된 폴리케티드 신타제를 코딩하는 핵산을 생산하는 단계이며, 여기서 변형된 폴리케티드 신타제는 단계 (b)에서 확인된 적어도 1개의 이종 모듈을 포함하는 것인 단계를 포함하는, 화합물을 생산하는 방법을 제공한다.
또 다른 측면에서, 개시내용은 복수의 조작된 폴리케티드 신타제를 생산하는 방법을 제공하며, 여기서 각각의 복수의 폴리뉴클레오티드는 조작된 폴리케티드 신타제에 상응하고, 각각의 복수의 폴리뉴클레오티드는 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함한다. 상기 방법은 (a) 폴리케티드 신타제를 코딩하는 모 폴리뉴클레오티드 서열을 제공하는 단계; (b) 모 폴리뉴클레오티드 서열 내 대체를 위한 1개 이상의 모듈을 확인하는 단계; (c) 단계 (b)에서 확인된 각각의 모듈에 대한 대체에 적합한 2개 이상의 이종 모듈을 확인하는 단계; (d) 복수의 폴리뉴클레오티드를 생성하는 단계이며, 여기서 각각의 복수의 폴리뉴클레오티드는 조작된 폴리케티드 신타제에 상응하고, 각각의 복수의 폴리뉴클레오티드는 단계 (b)에서 확인된 대체될 각각의 1개 이상의 모듈 대신에 단계 (c)에서 확인된 2개 이상의 이종 모듈로부터 선택된 이종 모듈을 포함하는 것인 단계를 포함한다.
정의
"폴리케티드 신타제"는 폴리케티드를 생산할 수 있는 다중-도메인 효소의 패밀리에 속하는 효소를 지칭한다. 폴리케티드 신타제는 박테리아, 진균, 식물, 또는 동물에서 자연적으로 발현될 수 있다.
본원에 사용된 용어 "조작된 폴리케티드 신타제"는 그의 설계 및/또는 생산이 인간의 수작업을 수반한, 비-천연 폴리케티드 신타제를 기재하는데 사용된다. 예를 들어, 일부 실시양태에서, "조작된" 폴리케티드 신타제는 폴리케티드 신타제를 코딩하는 비-천연 폴리뉴클레오티드의 생산에 의해 제조된다.
"함유하도록 조작된" 및/또는 "발현하도록 조작된" 세포는 세포에서 자연 발생하지 않는 단백질을 함유하도록 및/또는 발현하도록 변형된 세포를 지칭한다. 세포는, 예를 들어, 핵산을 포함하는 벡터의 도입에 의해 단백질을 코딩하는 핵산을 도입함으로써 단백질을 함유하도록 조작될 수 있다.
본원에 사용된 용어 "소분자를 생산하는 유전자 클러스터" 또는 "화합물을 생산하는 유전자 클러스터"는 1종 이상의 화합물-생산 단백질을 코딩하는 유전자의 클러스터를 지칭한다.
본원에 사용된 용어 "이종"은 자연에 존재하지 않는 2종 이상의 단백질, 핵산, 화합물 및/또는 세포 사이의 관계를 지칭한다. 예를 들어, 서열식별번호: 177의 서열을 갖는 LAL은 S18 스트렙토미세스 균주에서 자연 발생하고, 따라서 그러한 균주에 대해 동종이며, 따라서 S12 스트렙토미세스 균주에 대해서는 이종일 것이다.
용어 "동종" 또는 "천연"은 본원에서 상호교환가능하게 사용되고, 자연적으로 존재하는 2종 이상의 단백질, 핵산, 화합물 및/또는 세포 사이의 관계를 지칭한다. 예를 들어, 서열식별번호: 177의 서열을 갖는 LAL은 S18 스트렙토미세스 균주에서 자연 발생하고, 따라서 그러한 균주에 대해 동종이다.
본원에 사용된 용어 "재조합"은 합성 방법을 사용하여 생산된 단백질을 지칭한다.
본원에 사용된 용어 "참조 폴리케티드 신타제"는 변형된 1개 이상의 모듈의 서열을 제외하고, 조작된 폴리케티드 신타제의 서열에 대해 적어도 80% 동일성 (예를 들어, 적어도 80% 동일성, 적어도 85% 동일성, 적어도 90% 동일성, 적어도 95% 동일성, 적어도 99% 동일성, 또는 100% 동일성)을 갖는 서열을 갖는 폴리케티드 신타제를 지칭한다.
본원에 사용된 용어 "상용성"은 2개의 인접한 모듈이 폴리케티드 전위가 실질적으로 억제되지 않는, 적격인 모듈-모듈 접합부를 형성할 가능성의 척도를 지칭한다. 이종 모듈은 하기 기준 중 적어도 하나를 충족시킨다면 상용성인 것으로 간주될 수 있다: 1) 모듈이 본 발명의 상세한 설명에 기재된 모듈-수준 계통 분류에 의해 결정된 바와 같이, 참조 PKS의 1개 이상의 인접한 모듈과 동일한 모듈 계통군에 존재함; 2) 모듈이 본 발명의 상세한 설명에 기재된 모듈간 공변동 분석 알고리즘에서 0.90 이상의 점수에 배정됨; 또는 3) 모듈이 본 발명의 상세한 설명에 약술된 진화적 흔적 방법론에 의해 결정된 바와 같이, 참조 PKS의 1개 이상의 인접한 모듈과 동일한 기능적 계통군 또는 하위-계통군에 속함.
본원에 사용된 용어 "연결 서열"은 모듈간 접합부의 바로 상류 또는 하류의 서열을 지칭한다. 예를 들어, 단일 모듈 스와프에서, 동종 모듈 상류의 ACP, 삽입된 이종 모듈의 ACP 및 KS-AT 이중도메인, 및 동종 모듈 하류의 KS는 모두 연결 서열로 간주될 수 있다.
본원에 사용된 용어 "모듈"은 다중 도메인을 포함하는 폴리케티드 신타제의 영역을 지칭한다. 폴리케티드 신타제에 존재하는 모듈은 i) 로딩 모듈; ii) 연장 모듈; 및 iii) 최종 폴리케티드가 선형인지 시클릭인지에 따라 좌우되는 방출 및/또는 고리화 모듈을 포함할 수 있다. 주어진 모듈에 포함될 수 있는 도메인은 아실트랜스퍼라제 (AT), 아실 담체 단백질 (ACP), 케토-신타제 (KS), 케토리덕타제 (KR), 데히드라타제 (DH), 에노일리덕타제 (ER), 메틸트랜스퍼라제 (MT), 술프히드롤라제 (SH), 및 티오에스테라제 (TE)를 포함하나, 이에 제한되지는 않는다.
본원에 사용된 용어 "수용자 모듈"은 모듈 스와핑에 의한 조작에 적용되는 PKS 클러스터 내의 동종 모듈을 지칭한다. 생성된 조작된 PKS 클러스터에서, 수용자 모듈은 부재한다.
본원에 사용된 용어 "공여자 모듈"은 조작된 PKS 클러스터 내로 도입되는 이종 모듈을 지칭한다.
본원에 사용된 용어 "모듈 스와핑"은 1개 이상의 이종 공여자 모듈과 1개 이상의 동종 수용자 모듈의 교환을 지칭한다.
본원에 사용된 용어 "폴리케티드 전위를 실질적으로 억제하지 않는다"는 생합성 조립 라인에서 기능하는 이종 PKS 모듈의 능력을 지칭한다. 예를 들어, 이종 로딩 모듈은, 로딩 모듈이 그의 ACP 도메인 상에 출발물 단위를 로딩할 수 있고 출발물 단위가 인접한 (n+1) 연장기 모듈의 KS 도메인으로 전해질 수 있는 경우에, 폴리케티드 전위를 실질적으로 억제하지 않는다. 이종 연장기 모듈은, 연장기 모듈이 이전 (n-1) 모듈로부터 출발물 단위 또는 폴리케티드 쇄를 수신할 수 있고, 연장기 단위의 부가를 촉매할 수 있고, 신장된 폴리케티드 쇄가 인접한 (n+1) 모듈로 전해질 수 있는 경우에, 폴리케티드 전위를 실질적으로 억제하지 않는다. 일부 실시양태에서, 이종 모듈은, 이종 모듈을 포함하는 조작된 PKS가 고도로 감수성인 검출 방법, 예를 들어, LC-TOF 질량 분광측정법에 의해 검출가능한 수준으로 화합물을 생산하는 경우에, 폴리케티드 전위를 실질적으로 억제하지 않는다.
연장기 단위, 예를 들어, 말로닐-CoA는 또 다른 아실트랜스퍼라제 도메인에 의해 촉매되는 현재의 모듈의 아실 담체 단백질 도메인 상에 로딩된다. 이어서 폴리케티드 쇄는 모듈 n의 아실 담체 단백질 도메인으로부터 n+1 모듈의 케토신타제 도메인으로 전해진 후 후속 연장기 모듈에 의해 신장된다. 연장기 단위에 결합된 아실 담체 단백질은 케토신타제 도메인에 결합된 폴리케티드 쇄와 함께 CO2를 배출하면서 반응하여 아실 담체 단백질에 결합된 연장된 폴리케티드 쇄를 생산한다. 이어서 각각의 부가된 연장기 단위는 β-케토프로세싱 도메인, 즉, 케토리덕타제 (신장 기의 카르보닐을 히드록시로 환원시킴), 데히드라타제 (H2O를 배출하여 알켄을 생산함), 및 에노일리덕타제 (알켄을 환원시켜 포화 탄화수소를 생산함)에 의해 변형될 수 있다.
도 1a 및 1b는 PKS 생합성이 진행되는 메카니즘을 예시하는 개략도이다. 도 1a는 모듈 내에서의 폴리케티드 쇄 신장 및 β-카르보닐 프로세싱을 도시한다. 도 1b는 모듈 사이의 번역을 도시한다.
도 2a는 모듈-모듈 접합부에서의 기능적 단백질-단백질 상호작용의 예측에 대한 상보적 생물정보학 접근법을 도시한 다이어그램이다.
도 2b는 완전한 FK-패밀리 모듈의 다중 서열 정렬로부터 생성된 계통수이다.
도 2c-2e는 모듈간 잔기 공변동을 사용하여 모듈-모듈 접합부 상용성을 등급화하는 알고리즘을 생성하는 방법을 도시한다. 도 2c는 주어진 이종 모듈의 상용성을 결정하는데 사용된 상류 및 하류 모듈-모듈 접합부를 예시하는 다이어그램이다. 도 2d는 주어진 모듈의 ACP 도메인 및 제2 모듈의 KS-AT 이중도메인의 정렬을 도시한 상관관계 지도이다. 도 2e는 일련의 이종 모듈에 대한 도메인간 잔기 공변동 분석으로부터의 상용성 점수를 도시한다. 점수는 1.00의 점수가 주어진 해당 폴리케티드 신타제에 대한 동종 모듈에 대해 정규화된다.
도 2f 및 2g는 진화적 흔적 분석을 사용하여 모듈-모듈 접합부 상용성을 예측하는 방법을 도시한다. 도 2f는 FK-패밀리 KS 및 ACP 도메인의 다중 서열 정렬에 의해 생성된 계통수이며, 여기서 군-특이적 잔기는 기능적 계통군 또는 하위-계통군으로 이어진다. 모듈 사이의 거리를 사용하여 모듈-모듈 접합부 상용성을 예측할 수 있다. 도 2g는 FK-패밀리에 대한 KS 및 ACP 도메인 사이의 진화적 흔적 분석에 의해 예측된 상용성 관계를 도시한 개략도이다.
도 3a는 공여자 모듈이 화합물 1을 생산하는 PKS 유전자 클러스터의 모듈 3 또는 모듈 4를 대체하는 단일 모듈 스와프를 도시한 개략도이다.
도 3b는 화합물 1을 생산하는 PKS 내의 동종 모듈 3 대신 S17 스트렙토미세스 균주로부터의 이종 모듈 3을 포함하는 조작된 PKS의 영상이다. 조작된 PKS 모듈 3은 이제 ER 도메인을 포함하고, 따라서 조작된 PKS에 의해 생산되는 결과적인 화합물, 화합물 2는 화합물 1에 비해 환원된다.
도 3c는 화합물 1을 생산하는 PKS 내의 모듈 3 또는 모듈 4의, 상용성 이종 모듈에 의한 단일 모듈 스와프에 의해 생산된 화합물, 예를 들어, 화합물 2, 화합물 3, 화합물 4, 및 화합물 5를 도시한 영상이다.
도 4a는 이중모듈 단위의 조합 스와핑을 도시한 개략도이다.
도 4b는 제1 라운드의 깁슨 조립에 의한 외인성 공여자 모듈로부터의 이중모듈 단위의 합성을 도시한 개략도이다. 이중모듈 생성물은 DNA 겔 전기영동에 의해 분석된 바와 같이 제시된다.
도 4c는 셔틀 벡터에서의 이중모듈 포획, 증폭, 및 풍부화를 도시한 개략도이다. 제1 라운드의 깁슨 조립으로부터 생성된 이중모듈 단위는 제2 라운드의 깁슨 조립에 의해 셔틀 벡터 내에 포획된다. 이는 이중모듈 조립이 증폭되고, 풍부화되고, 의도되는 PKS에 라이게이션되게 한다.
도 4d는 조합 합성에 의한 이중모듈 라이브러리의 구축을 도시한 개략도이다.
도 4e는 화합물 1을 생산하는 PKS의 모듈 3 및 모듈 4 내로 스와핑된 예시적인 이중모듈 라이브러리에 의해 생성될 수 있는 가능한 결과적인 화합물을 도시한 영상이다.
도 4f는 대형 조합 이중모듈 라이브러리의 충분한 커버리지에 필요한 과다샘플링을 도시한다. 도 4f는 225종 구성원 이중모듈 조합 라이브러리의 90% 이상의 커버리지를 달성하는데 필요한 과다샘플링의 그래프 표현이다. 650개의 샘플링된 클론 중 18%가, LC-TOF 질량 분광측정 분석에 의해 결정된 바와 같이, 조작된 PKS 클러스터로부터 생성되는 폴리케티드 화합물을 생산하는 것으로 확인되었다.
도 4g는 조합 이중모듈 라이브러리를 제조하고 생성된 라이브러리를 나노포어 서열분석을 사용하여 특징화하는 방법을 도시한 개략도이다.
도 4h는 나노포어 서열분석에 의해 조합 이중모듈 라이브러리의 서열을 디컨볼루션하는 핵심 정보학 작업흐름을 도시한 개략도이다.
도 5a 및 5b는 조합 합성에 의한 삼중모듈 라이브러리의 구축을 도시한다. 도 5a는 2,197개의 조작된 폴리케티드 신타제의 이론적 라이브러리 크기를 생산하기 위한, 화합물 7을 생산하는 PKS 클러스터의 모듈 4, 5, 및 6의 삼중모듈 스와프를 예시하는 개략도이다. 도 5b는 DNA 겔 전기영동에 의해 분석된 바와 같은, 깁슨 조립에 의한 높은 효율 삼중모듈 조립의 영상이다.
도 6a는 단일 모듈 수용자와 이중모듈 공여자를 교환하는 것에 의해 고리 연장이 발생한 모듈 스와프를 예시하는 개략도이다. 조작된 PKS에 의해 생산된 결과적인 연장된 고리 화합물, 화합물 8이 또한 도시된다.
도 6b는 LC-TOF 질량 분광측정법에 의해 분석된 바와 같은, 확장된 고리 화합물, 화합물 8의 생산을 보여주는 분광도이다.
도 7a는 라파마이신 및 신규 PKS 클러스터, X23을 포함한 5종의 PKS 로딩 모듈의 효소적 도메인을 도시한 개략도이다. 또한 각각의 로딩 모듈과 회합된 출발물 단위를 제시한다.
도 7b는 X23 PKS 클러스터에서 단일 모듈 스와프로부터 생성된, 조작된 PKS 클러스터에 의해 생산된 화합물을 도시한다. 생성물은 이종 로딩 모듈을 함유하는 조작된 PKS에 의해 생산된 화합물 11 및 12를 포함한다.
도 2a는 모듈-모듈 접합부에서의 기능적 단백질-단백질 상호작용의 예측에 대한 상보적 생물정보학 접근법을 도시한 다이어그램이다.
도 2b는 완전한 FK-패밀리 모듈의 다중 서열 정렬로부터 생성된 계통수이다.
도 2c-2e는 모듈간 잔기 공변동을 사용하여 모듈-모듈 접합부 상용성을 등급화하는 알고리즘을 생성하는 방법을 도시한다. 도 2c는 주어진 이종 모듈의 상용성을 결정하는데 사용된 상류 및 하류 모듈-모듈 접합부를 예시하는 다이어그램이다. 도 2d는 주어진 모듈의 ACP 도메인 및 제2 모듈의 KS-AT 이중도메인의 정렬을 도시한 상관관계 지도이다. 도 2e는 일련의 이종 모듈에 대한 도메인간 잔기 공변동 분석으로부터의 상용성 점수를 도시한다. 점수는 1.00의 점수가 주어진 해당 폴리케티드 신타제에 대한 동종 모듈에 대해 정규화된다.
도 2f 및 2g는 진화적 흔적 분석을 사용하여 모듈-모듈 접합부 상용성을 예측하는 방법을 도시한다. 도 2f는 FK-패밀리 KS 및 ACP 도메인의 다중 서열 정렬에 의해 생성된 계통수이며, 여기서 군-특이적 잔기는 기능적 계통군 또는 하위-계통군으로 이어진다. 모듈 사이의 거리를 사용하여 모듈-모듈 접합부 상용성을 예측할 수 있다. 도 2g는 FK-패밀리에 대한 KS 및 ACP 도메인 사이의 진화적 흔적 분석에 의해 예측된 상용성 관계를 도시한 개략도이다.
도 3a는 공여자 모듈이 화합물 1을 생산하는 PKS 유전자 클러스터의 모듈 3 또는 모듈 4를 대체하는 단일 모듈 스와프를 도시한 개략도이다.
도 3b는 화합물 1을 생산하는 PKS 내의 동종 모듈 3 대신 S17 스트렙토미세스 균주로부터의 이종 모듈 3을 포함하는 조작된 PKS의 영상이다. 조작된 PKS 모듈 3은 이제 ER 도메인을 포함하고, 따라서 조작된 PKS에 의해 생산되는 결과적인 화합물, 화합물 2는 화합물 1에 비해 환원된다.
도 3c는 화합물 1을 생산하는 PKS 내의 모듈 3 또는 모듈 4의, 상용성 이종 모듈에 의한 단일 모듈 스와프에 의해 생산된 화합물, 예를 들어, 화합물 2, 화합물 3, 화합물 4, 및 화합물 5를 도시한 영상이다.
도 4a는 이중모듈 단위의 조합 스와핑을 도시한 개략도이다.
도 4b는 제1 라운드의 깁슨 조립에 의한 외인성 공여자 모듈로부터의 이중모듈 단위의 합성을 도시한 개략도이다. 이중모듈 생성물은 DNA 겔 전기영동에 의해 분석된 바와 같이 제시된다.
도 4c는 셔틀 벡터에서의 이중모듈 포획, 증폭, 및 풍부화를 도시한 개략도이다. 제1 라운드의 깁슨 조립으로부터 생성된 이중모듈 단위는 제2 라운드의 깁슨 조립에 의해 셔틀 벡터 내에 포획된다. 이는 이중모듈 조립이 증폭되고, 풍부화되고, 의도되는 PKS에 라이게이션되게 한다.
도 4d는 조합 합성에 의한 이중모듈 라이브러리의 구축을 도시한 개략도이다.
도 4e는 화합물 1을 생산하는 PKS의 모듈 3 및 모듈 4 내로 스와핑된 예시적인 이중모듈 라이브러리에 의해 생성될 수 있는 가능한 결과적인 화합물을 도시한 영상이다.
도 4f는 대형 조합 이중모듈 라이브러리의 충분한 커버리지에 필요한 과다샘플링을 도시한다. 도 4f는 225종 구성원 이중모듈 조합 라이브러리의 90% 이상의 커버리지를 달성하는데 필요한 과다샘플링의 그래프 표현이다. 650개의 샘플링된 클론 중 18%가, LC-TOF 질량 분광측정 분석에 의해 결정된 바와 같이, 조작된 PKS 클러스터로부터 생성되는 폴리케티드 화합물을 생산하는 것으로 확인되었다.
도 4g는 조합 이중모듈 라이브러리를 제조하고 생성된 라이브러리를 나노포어 서열분석을 사용하여 특징화하는 방법을 도시한 개략도이다.
도 4h는 나노포어 서열분석에 의해 조합 이중모듈 라이브러리의 서열을 디컨볼루션하는 핵심 정보학 작업흐름을 도시한 개략도이다.
도 5a 및 5b는 조합 합성에 의한 삼중모듈 라이브러리의 구축을 도시한다. 도 5a는 2,197개의 조작된 폴리케티드 신타제의 이론적 라이브러리 크기를 생산하기 위한, 화합물 7을 생산하는 PKS 클러스터의 모듈 4, 5, 및 6의 삼중모듈 스와프를 예시하는 개략도이다. 도 5b는 DNA 겔 전기영동에 의해 분석된 바와 같은, 깁슨 조립에 의한 높은 효율 삼중모듈 조립의 영상이다.
도 6a는 단일 모듈 수용자와 이중모듈 공여자를 교환하는 것에 의해 고리 연장이 발생한 모듈 스와프를 예시하는 개략도이다. 조작된 PKS에 의해 생산된 결과적인 연장된 고리 화합물, 화합물 8이 또한 도시된다.
도 6b는 LC-TOF 질량 분광측정법에 의해 분석된 바와 같은, 확장된 고리 화합물, 화합물 8의 생산을 보여주는 분광도이다.
도 7a는 라파마이신 및 신규 PKS 클러스터, X23을 포함한 5종의 PKS 로딩 모듈의 효소적 도메인을 도시한 개략도이다. 또한 각각의 로딩 모듈과 회합된 출발물 단위를 제시한다.
도 7b는 X23 PKS 클러스터에서 단일 모듈 스와프로부터 생성된, 조작된 PKS 클러스터에 의해 생산된 화합물을 도시한다. 생성물은 이종 로딩 모듈을 함유하는 조작된 PKS에 의해 생산된 화합물 11 및 12를 포함한다.
본 발명은 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제에 의해 폴리케티드 화합물을 생산하기 위한 조성물 및 방법을 기재한다. 본 발명은 또한 폴리케티드 생합성 동안 전위를 실질적으로 억제하지 않는 조작된 폴리케티드 신타제를 생산하기 위해 이종 모듈-모듈 접합부의 연결 서열의 상용성을 예측하는 방법을 기재한다.
화합물
본 발명의 방법에 의해 생산될 수 있는 화합물은 폴리케티드 및 폴리케티드 마크롤리드 항생제 예컨대 에리트로마이신; 하이브리드 폴리케티드/비-리보솜 펩티드 예컨대 라파마이신 및 FK506; 탄수화물 포함 아미노글리코시드 항생제 예컨대 겐타미신, 카나마이신, 네오마이신, 토브라마이신; 벤조푸라노이드; 벤조피라노이드; 플라보노이드; 당펩티드 포함 반코마이신; 리포펩티드 포함 답토마이신; 탄닌; 리그난; 폴리시클릭 방향족 천연 생성물, 테르페노이드, 스테로이드, 스테롤, 옥사졸리디논 포함 리네졸리드; 아미노산, 펩티드 및 펩티드 항생제 예컨대 폴리믹신, 비-리보솜 펩티드, β-락탐 항생제, 예컨대 카르바페넴, 세팔로스포린, 및 페니실린; 퓨린, 프테리딘, 폴리피롤, 테트라시클린, 퀴놀론 및 플루오로퀴놀론; 및 술폰아미드를 포함하나, 이에 제한되지는 않는다.
단백질
폴리케티드 신타제
폴리케티드 신타제 (PKS)는 폴리케티드를 생산하는 다중-도메인 효소의 패밀리이다. 유형 I 폴리케티드 신타제는 모듈로 조직화된 여러 도메인을 포함하는 대형의, 모듈 단백질이다. 폴리케티드 신타제에 일반적으로 존재하는 모듈은 i) 로딩 모듈; ii) 연장 모듈; 및 iii) 최종 폴리케티드가 선형인지 시클릭인지에 따라 좌우되는 방출 및/또는 고리화 모듈을 포함한다. 모듈에서 일반적으로 발견되는 도메인은 아실트랜스퍼라제 (AT), 아실 담체 단백질 (ACP), 케토-신타제 (KS), 케토리덕타제 (KR), 데히드라타제 (DH), 에노일리덕타제 (ER), 메틸트랜스퍼라제 (MT), 술프히드롤라제 (SH), 및 티오에스테라제 (TE)이다.
폴리케티드 쇄 및 출발물 기는 일반적으로 티오에스테르 연결을 통해 케토신타제 도메인 (폴리케티드 쇄) 및 아실트랜스퍼라제 도메인 (로딩 기 및 말로닐 연장기 단위) 내의 활성 부위 시스테인의 티올 기에 결합된다. 아실 담체 단백질 (ACP)에 대한 결합은 포스포판테테이닐 기의 티올에 의해 매개되고, 이는 ACP의 세린 히드록실에 결합되어, 성장하는 폴리케티드 쇄에 티오에스테르 연결을 형성한다. 성장하는 폴리케티드 쇄는 트랜스-아실화에 의해 1개의 티올 기에서 또 다른 것으로 넘겨지고, 합성 후 가수분해 또는 고리화에 의해 방출된다.
폴리케티드의 합성은 로딩 모듈의 아실트랜스퍼라제에 의해 촉매되는 PKS의 아실 담체 단백질 도메인 상에 로딩되는 출발물 단위에 의해 시작된다. 연장기 단위, 예를 들어, 말로닐-CoA는 또 다른 아실트랜스퍼라제 도메인에 의해 촉매되는 현재의 모듈의 아실 담체 단백질 도메인 상에 로딩된다. 이어서 폴리케티드 쇄는 모듈 n의 아실 담체 단백질 도메인으로부터 n+1 모듈의 케토신타제 도메인으로 전해진 후 후속 연장기 모듈에 의해 신장된다. 연장기 단위에 결합된 아실 담체 단백질은 케토신타제 도메인에 결합된 폴리케티드 쇄와 함께 CO2를 배출하면서 반응하여 아실 담체 단백질에 결합된 연장된 폴리케티드 쇄를 생산한다. 이어서 각각의 부가된 연장기 단위는 β-케토프로세싱 도메인, 즉, 케토리덕타제 (신장 기의 카르보닐을 히드록시로 환원시킴), 데히드라타제 (H2O를 배출하여 알켄을 생산함), 및 에노일리덕타제 (알켄을 환원시켜 포화 탄화수소를 생산함)에 의해 변형될 수 있다. 폴리케티드의 합성이 완성되면, 방출 모듈의 티오에스테라제 도메인은 마지막 연장 모듈의 아실 담체 단백질로부터 완성된 폴리케티드 쇄를 가수분해한다. 이어서 PKS로부터 방출된 화합물은 다른 단백질, 예를 들어, 비리보솜 펩티드 신타제에 의해 추가로 변형될 수 있다. 일부 경우에, 생합성 클러스터는 폴리케티드 메가신타제 및 비-리보솜 펩티드 신타제 (NRPS)를 보유한다. 이러한 하이브리드 아키텍처는 하이브리드 PKS/NRPS로 지칭된다.
폴리케티드 신타제 연장기 모듈
PKS 생합성은 2가지 주요 메카니즘: 모듈 내에서의 폴리케티드 쇄 신장 및 모듈 사이에서의 전위에 의해 진행된다 (도 1a 및 1b). 폴리케티드 신타제 클러스터의 기본 기능적 단위는 연장기 모듈이며, 이는 말로닐-CoA로부터 유래된 2-탄소 연장기 단위를 코딩한다. 연장기 모듈 내에서, 폴리케티드 쇄 신장에 필요한 최소 도메인 아키텍처는 케토신타제 (KS), 아실-트랜스퍼라제 (AT) 및 ACP (아실-담체 단백질) 도메인을 포함하고, 각각의 모듈의 특이적 화학은 AT 도메인에 의해 및 베타-카르보닐 프로세싱 도메인: 케토리덕타제 (KR), 데히드라타제 (DH), 및 에노일리덕타제 (ER) 도메인의 존재에 의해 코딩된다. 생산적 쇄 신장은 수많은 도메인의 협동 기능에 좌우된다.
β-케톤 프로세싱 도메인
β-케톤 프로세싱 도메인은 폴리케티드의 합성 동안 부가된 신장 기의 변형을 발생시키는 PKS 내의 도메인이다. 각각의 β-케톤 프로세싱 도메인은 신장 기의 산화 상태를 변화시킬 수 있다. β-케톤 프로세싱 도메인은 케토리덕타제 (신장 기의 카르보닐을 히드록시로 환원시킴), 데히드라타제 (H2O를 배출하여 알켄을 생산함), 및 에노일리덕타제 (알켄을 환원시켜 포화 탄화수소를 생산함)을 포함한다.
조작된 폴리케티드 신타제를 생산하기 위한 모듈 스와핑
본 개시내용은 관련 PKS 클러스터 사이에서 모듈을 스와핑함으로써 생산되는, 조작된 폴리케티드 신타제에 관한 방법 및 조성물을 제공한다. 폴리케티드 전위는 모듈간 접합부에서의 단백질-단백질 상호작용에 의해 제어된다. 일부 실시양태에서, 모듈 스와핑은 어떠한 모듈이 조립-라인 폴리케티드 생합성에서 기능할 최고의 확률을 갖는지 결정하는 생물정보학적 예측에 의해 안내된다. PKS 서열 정렬의 구조적 정보를 결정하여 모듈간 접합부에서 폴리케티드 전위를 매개하는 단백질-단백질 상호작용을 예측하기 위해 다중 생물정보학 방법이 사용된다. 본 개시내용은 1개 이상의 이종 공여자 모듈을 1개 이상의 수용자 모듈과 스와핑하여 하이브리드 PKS 클러스터를 생성하기 위한 DNA 조립 전략을 포함한다.
일부 실시양태에서, 모듈 스와핑은 단일, 이중- 또는 삼중-, 또는 다중-모듈 포획에 의해 달성된다. 일부 실시양태에서, 모듈 스와핑은 로딩 모듈의 교환에 의해 수행될 수 있다. 일부 실시양태에서, 모듈 스와핑은 1개 이상의 연장기 모듈의 교환에 의해 수행될 수 있다. 일부 실시양태에서, 모듈 스와핑은 1개 이상의 방출 또는 고리화 모듈의 교환에 의해 수행될 수 있다. 일부 실시양태에서, 2개 이상의 이종 공여자 모듈은 단일 수용자 모듈을 대체할 수 있고, 이는 고리-확장된 화합물의 생산을 발생시킬 수 있다. 일부 실시양태에서, 단일 이종 공여자 모듈은 2개 이상의 수용자 모듈을 대체할 수 있고, 이는 수축된 고리 화합물을 발생시킬 수 있다. 일부 실시양태에서, 조작된 폴리케티드 신타제는 신규 화합물을 생산할 수 있다.
조작된 폴리케티드 신타제의 조합 라이브러리
일부 실시양태에서, 단일, 이중- 또는 삼중-, 또는 다중-모듈 단위의 풀링된 포획 및 전달은 조작된 폴리케티드 신타제의 조합 라이브러리의 생산을 가능하게 한다. 이중모듈 단위는 예를 들어 2개의 이종 모듈로 이루어지고, 이들 각각은 이종 모듈의 풀로부터 독립적으로 선택될 수 있다. 삼중모듈 단위는 예를 들어 3개의 이종 모듈로 이루어지고, 이들 각각은 이종 모듈의 풀로부터 독립적으로 선택될 수 있다. 폴리케티드 신타제의 1개 이상의 모듈은 단일, 이중-, 삼중-, 또는 다중-모듈 단위에 의해 대체될 수 있고, 여기서 단일, 이중-, 삼중-, 또는 다중-모듈 단위는 조합 합성에 의해 생산된 단일-, 이중-, 삼중-, 또는 다중-모듈 단위의 풀로부터 선택된다. 조작된 폴리케티드 신타제의 조합 라이브러리 (예를 들어, 이중모듈 및 삼중모듈 조합 라이브러리)의 생산을 위한 예시적인 방법이 실시예 2 및 4에 제공된다.
단일-분자 긴-판독물 서열분석에 의한 조작된 PKS 라이브러리의 특징화
본 발명의 일부 실시양태에서, 본원에 기재된 방법 중 임의의 것에 의해 생산된 조작된 폴리케티드 신타제의 라이브러리를 특징화하는데 단일-분자 긴-판독물 서열분석 기술 (예를 들어, 나노포어 서열분석 또는 SMRT 서열분석)이 사용될 수 있다. 특히, 단일-분자 긴-판독물 서열분석 (예를 들어, 나노포어 서열분석 또는 SMRT 서열분석)은 조작된 폴리케티드 신타제의 조합 라이브러리 (예를 들어, 단일, 이중- 또는 삼중-, 또는 다중-모듈 단위의 풀링된 포획 및 전달에 의해 생산된 조작된 폴리케티드 신타제의 조합 라이브러리)를 특징화 (예를 들어, 디컨볼루션)하는데 사용될 수 있다. 단일-분자 긴-판독물 서열분석은 조합 라이브러리 내로 혼입된 모듈 또는 모듈들의 확인을 가능하게 한다. 이는 추가로, 생성되는 복수의 조작된 폴리케티드 신타제의 화학을 예측 가능하게 한다. 따라서 예측된 효소 화학은 조작된 폴리케티드 신타제에 의해 생산되는 화합물과 연결될 수 있다. 생성된 화합물은 관련 기술분야의 통상의 기술자에게 공지된 화학적 분석 방법 (예를 들어, 질량 분광측정법 또는 고성능 액체 크로마토그래피)에 의해 확인될 수 있다. 또한, 예측된 효소 화학은 생성되는 화합물의 기능 (예를 들어, 표적 단백질에의 결합 또는 표현형, 예컨대 세포 기반 표현형의 유도)과 연결될 수 있다. 따라서, 유전자 코딩된 분자의 긴-판독물 서열분석은 유전자형-표현형 연관을 가능하게 할 수 있다.
단일-분자 긴-판독물 서열분석 기술은 생체중합체 (예를 들어, 폴리뉴클레오티드 예컨대 DNA 또는 RNA)의 단일 분자의 서열분석을 가능하게 하고, 2 킬로염기 초과 (예를 들어, 5 킬로염기 초과, 10 킬로염기 초과, 20 킬로염기 초과, 50 킬로염기 초과, 또는 100 킬로염기 초과)의 판독물 길이의 서열분석을 가능하게 하는 임의의 서열분석 기술을 포함하는 것으로 생각될 수 있다. 단일-분자 긴-판독물 서열분석 기술은 DNA 또는 RNA의 다중 단일 분자의 병행 서열분석을 가능하게 할 수 있다. 단일-분자 긴-판독물 서열분석 기술은 서열분석되는 DNA 또는 RNA의 각각의 분자의 개별 구획화에 의존하는 서열분석 기술을 포함할 수 있다.
나노포어 서열분석은 본원에 기재된 방법 중 임의의 것에 의해 제조된 조작된 폴리케티드 신타제의 라이브러리를 특징화하는데 사용될 수 있는 예시적인 단일-분자 긴-판독물 서열분석 기술이다. 나노포어 서열분석은 생체중합체 (예를 들어, 폴리뉴클레오티드 예컨대 DNA 또는 RNA)의 단일 분자의 긴-판독물 서열분석을 가능하게 한다. 나노포어 서열분석은 전기 저항성 중합체 막에 세팅된 단백질 나노포어에 의존한다. 이온 전류는 이러한 막을 가로질러 전압을 세팅함으로써 나노포어를 통과한다. 분석물 (예를 들어, 생체중합체 예컨대 DNA 또는 RNA)이 포어 또는 그의 개구 근처를 통과하면, 이러한 사건은 전류의 특징적인 교란을 생성한다. 나노포어 표면을 가로지르는 전류 밀도의 크기는 나노포어를 점유하는 DNA 또는 RNA (예를 들어, 특정 염기)의 조성에 좌우된다. 따라서, 전류의 측정은 해당 분자의 서열의 확인을 가능하게 한다. 조작된 폴리케티드 신타제의 조합 라이브러리를 특징화하기 위한 나노포어 서열분석의 사용에 대한 예시적인 방법이 실시예 3에 제공된다.
단일 분자 실시간 (SMRT) 서열분석 (PacBio)은 본원에 기재된 방법 중 임의의 것에 의해 제조된 조작된 폴리케티드 신타제의 라이브러리를 특징화하는데 사용될 수 있는 예시적인 단일-분자 긴-판독물 서열분석 기술이다. SMRT는 병렬화된 단일 분자 DNA 서열분석 방법이다. SMRT는 제로-모드 도파관 (ZMW)을 사용한다. 단일 DNA 폴리머라제 효소는 주형으로서 단일 분자의 DNA와 함께 ZMW의 하부에 고정된다. ZMW는 DNA 폴리머라제에 의해 혼입되는 DNA의 단일 뉴클레오티드만을 관찰하도록 충분히 작은, 조명된 관찰 부피를 생성하는 구조이다. 4개의 DNA 염기 각각은 4종의 상이한 형광 염료 중 1종에 부착된다. 뉴클레오티드가 DNA 폴리머라제에 의해 혼입되는 경우에, 형광 태그는 절단되어 그의 형광을 더 이상 관찰할 수 없는 ZMW의 관찰 구역 밖으로 확산된다. 검출기는 뉴클레오티드 혼입의 형광 신호를 검출하고, 염료의 상응하는 형광에 따라 염기 호출이 만들어진다.
기능적 모듈간 접합부의 예측을 위한 컴퓨터 접근법
본 개시내용은 모듈-모듈 접합부에서의 기능적 단백질-단백질 상호작용의 예측을 위한 상보적 생물정보학적 접근법을 제공한다 (도 2a). 일부 실시양태에서, 이들 생물정보학적 접근법은 모듈 스와핑에 의한 키메라 PKS 단백질의 설계를 위한 예측 기준으로서의 역할을 한다.
모듈-수준 계통
폴리케티드 모듈 및 모듈간 링커 사이의 서열 분기는 모듈-모듈 상용성에서 중요성을 시사한다. 일부 실시양태에서, 모듈-수준 계통 지도는 PKS 모듈의 다중 서열 정렬에 의해 구축될 수 있다. 예를 들어, 완전한 FK-패밀리 모듈의 다중 서열 정렬에 의해 모듈-수준 계통 지도를 생성하였다 (도 2b). 이는 8개의 신장, 1개의 로딩, 및 1개의 오프-로딩을 포함한 10개의 모듈 계통군의 확인을 가능하게 하였다. 일부 실시양태에서, 이종 모듈은 그에 인접한 모듈과 동일한 모듈 계통군에 존재하는 경우에 상용성이다.
모듈간 잔기 공변동
모듈간 접합부에 걸친 모듈간 잔기 공변동을 산출하여 모듈간 상용성 순서를 등급화하기 위한 알고리즘을 생성하였다 (도 2c-2e). 케토신타제 (KS) 및 아실 담체 단백질 (ACP) 도메인에 대해 훈련된 은닉 마르코프 모델을 사용하여 내부 데이터베이스 및 진뱅크(Genbank)로부터 유형 I 폴리케티드 신타제 단백질 서열을 추출하였다. 모듈의 ACP로 시작하여 다음 모듈의 KS 및 아실 트랜스퍼라제 (AT)까지 연장되는 보다 짧은 펩티드 서열을 추출하여 다중 정렬을 생성하였다. PDB 엔트리 2JU1 (ACP의 경우) 또는 2HG4 (KS 및 AT 및 회합된 링커의 경우)로부터의 아미노산과 정렬되지 않는 위치는 제거하여 다중 정렬를 압축시켰다. 이어서 패키지 프리콘택트(FreeContact)를 사용하여 진화적 커플링을 계산하였다. 이들 커플링은 2가지 지수를 갖는 점수 매트릭스 형태: 다중 정렬에서의 제1 아미노산 위치 (I) 및 다중 정렬에서의 제2 아미노산 위치 (J, 이는 항상 I보다 큼) 및 위치 J에서의 아미노산을 취한다. 명시된 컷오프를 초과하는 점수를 갖고 I가 ACP 내에 있고 J가 KS-AT 이중도메인 내에 있는 I,J 쌍이 세이브된다.
잠재적 단일 모듈 치환에 대한 점수를 생성하기 위해, 원래의 다중 정렬로부터 하기 정렬이 검색된다: 도메인 상류의 ACP, 삽입된 모듈의 ACP 및 KS-AT 이중도메인, 모듈 하류의 KS. 이들을 사용하여 원래의 다중 정렬과 상용성인 2개의 행을 합성한다: 하나는 모듈 상류의 ACP 및 삽입된 모듈의 KS-AT 및 제2는 삽입된 모듈의 ACP 및 모듈 하류의 KS-AT. 세이브된 커플링 매트릭스에서 각각의 I,J 쌍에 대해, 합성된 정렬에서 위치 I 및 J의 아미노산이 검색된다 (aaI, aaJ). 정렬 내의 아미노산 쌍에 대한 상호 정보는 커플링 점수와 곱해져 원점수를 생성한다. 원점수는 세이브된 커플링 매트릭스에서의 각각의 I,J 쌍에 대해, 및 2개의 합성된 정렬 각각에 대해 산출된다. 이종 공여자 도메인에 대한 원점수의 합계를 동종 천연 도메인에 대한 원점수의 합계로 나누어 정규화된 백분율 점수를 생성한다. 동일한 화학에 의한 후보 스와프가 이러한 점수에 의해 등급화된다. 다중 모듈 스와프의 경우에, 프로세스는 확장되고, 예를 들어 N 공여자 도메인이 스와핑되면, 선행 모듈의 ACP 도메인 및 제1 공여자 모듈의 KS-AT 이중도메인에 대해 1개의 합성 정렬이 생성되고, 제1 공여자 모듈의 ACP 도메인 및 제2 공여자 모듈의 KS-AT 이중도메인에 대해 또 다른 것이 생성되는 등이고, 최종 공여자 도메인의 ACP 및 절단점 하류의 수용자 신타제의 제1 모듈로 종결된다. 점수는 동일한 방식으로 산출 및 정규화되고: 스와핑된 모듈에 대한 점수는 천연 모듈에 대해 산출된 점수에 대해 정규화된다. 일부 실시양태에서, 이종 모듈은 모듈이 본원에 기재된 모듈간 공변동 분석 알고리즘에서 0.90 이상의 점수에 배정되는 경우에 상용성이다.
기능적 계통군 또는 하위-계통군 내의 모듈을 확인하기 위한 진화적 흔적 분석
모듈 상용성의 추가의 시험으로서, 동일한 기능적 계통군 또는 하위-계통군에 속하는 모듈을 확인하기 위해 진화적 흔적 분석이 사용될 수 있다 (도 2f-2g). 예를 들어, FK-패밀리 KS 및 ACP의 다중 서열 정렬에 기초하여 균일한 분지 길이를 갖는 계통수를 구축하였다. 계통수의 모든 비-말단 노드에 대해, 컷오프에서 공유되는 모 노드에 기초하여 말단 노드가 군으로 분할되는 수직 컷오프를 적용하였다. 모든 군에 걸쳐 전반적으로 보존된 잔기 및 군 내에서 국부적으로 보존되었지만 주어진 군에 특이적인 잔기를 기능적 잔기로 확인하였다. 전반적으로 보존된 잔기는 FK-패밀리의 모든 구성원에 대해 아마도 관찰되어야 하는 규정을 시사한다. 군-특이적 잔기는 FK 부류 내에서 조작에 대한 예측력을 제공할 수 있는 가이드라인을 시사한다. 각각의 계통수에 대해, 군-특이적 잔기의 수가 전반적으로 보존된 잔기의 수를 초과한 최초의 컷오프를 추가의 분석을 위해 선택하였다. 군-특이적 잔기는 기능적 계통군으로 이어졌고, 계통군의 뿌리없는 계통수가 구축되었다. 계통수에서 말단 노드 사이의 거리를 사용하여 진화적 거리 점수 (EDS)를 생성하였다. 동종 수용자 모듈 및 제안되는 이종 공여자 모듈 사이에서 KS 및 ACP EDS를 계산하고, 이를 사용하여 조작 상용성을 예측하였다. 이어서 KS 및 ACP 계통군 분류를 사용하여, 주어진 KS-ACP 또는 ACP-KS 쌍이 FK-패밀리 폴리케티드에서 관찰된 빈도에 의해 가중치를 부여하여, 이웃 KS 및 ACP의 네트워크 지도를 생성하였다. 제안되는 모듈 스와프를 네트워크 지도 상에 중첩시킴으로써 ACP 상류 및 KS 하류에 의한 조작 상용성을 예측하였다. 일부 실시양태에서, 이종 모듈은 모듈이 참조 PKS 내의 1개 이상의 인접한 모듈과 동일한 기능적 진화적 계통군 또는 하위-계통군에 속하는 경우에 상용성이다.
폴리케티드 신타제 발현의 조절
전사 활성인자의 LuxR 패밀리의 대형 ATP-결합 조절인자 (LAL)는 폴리케티드 예컨대 FK506 또는 라파마이신의 공지된 전사 조절인자이다. LAL 패밀리, 예를 들어 피크로마이신 생산을 위한 PikD 및 라파마이신 생산을 위한 RapH는 일부 유형의 천연 생성물 유전자 클러스터의 발현을 유도하는데 있어서 능동적인 역할을 하는 것으로 발견되었다. LAL 또는 복합체로의 다중 LAL이 소분자를 생산하는 유전자 클러스터 (예를 들어, 폴리케티드 신타제 유전자 클러스터) 내의 유전자의 프로모터의 특정 부위에 결합하면 유전자 클러스터의 발현이 강화되고, 따라서 화합물 (예를 들어, 폴리케티드)의 생산이 촉진된다. 일부 실시양태에서, LAL은 조작된 PKS 클러스터의 발현의 조절을 위해 사용될 수 있다.
LAL
LAL은 3개의 도메인, 뉴클레오티드-결합 도메인, 유도인자-결합 도메인, 및 DNA-결합 도메인을 포함한다. LAL을 포함하는 조절 단백질의 구조적 부류를 정의하는 특징은 AAA+ ATPase 도메인의 존재이다. 뉴클레오티드 가수분해는 단백질 및/또는 다량체화에서의 대형 입체형태적 변화와 커플링되고, 뉴클레오티드 결합 및 가수분해는 LAL의 활성 (예를 들어, LAL의 활성의 지속기간)을 제어하는 "분자 타이머"를 나타낸다. LAL은 유도인자 결합 부위에의 소분자 리간드의 결합에 의해 활성화된다. 대부분의 경우에 LAL의 알로스테릭 유도인자는 공지되어 있지 않다. 관련 단백질 MalT의 경우에, 알로스테릭 유도인자는 말토트리오스이다. LAL 단백질에 대한 가능한 유도인자는 화합물 (예를 들어, 폴리케티드) 생합성을 촉발하는 환경에서 발견되는 소분자를 포함한다. LAL의 조절은 외부 환경 자극의 존재 하에 화합물 (예를 들어, 폴리케티드) 생산의 활성화를 발생시키는 화합물-생산 단백질 (예를 들어, 폴리케티드 신타제)의 생산을 제어한다. 따라서, 균주 내에 존재하는 동안에는 (i) LAL이 활성화되어 있지 않거나, (ii) 균주가 컨센서스와 상이한 LAL 결합 부위를 갖거나, (iii) 균주에 LAL 조절인자가 결여되어 있거나, 또는 (iv) 실험실 조건 하에 LAL 조절인자가 불량하게 발현될 수 있거나 발현되지 않을 수 있기 때문에 화합물을 생산하지 않는, 소분자를 생산하는 유전자 클러스터 (예를 들어, PKS 유전자 클러스터)가 존재한다. 공지된 PKS LAL 중 LAL의 DNA 결합 영역은 고도로 보존되어 있기 때문에, 공지된 LAL은 자연적으로 조절되는 것 이외의 다른 PKS 유전자 클러스터를 활성화하기 위해 상호교환가능하게 사용될 수 있다. 일부 실시양태에서, LAL은 융합 단백질이다.
일부 실시양태에서, LAL은 비-LAL DNA-결합 도메인을 포함하여, 그에 의해 LAL 뉴클레오티드-결합 도메인 및 비-LAL DNA-결합 도메인을 포함하는 융합 단백질을 형성하도록 변형될 수 있다. 특정 실시양태에서, 비-LAL DNA-결합 도메인은, DNA-결합 도메인의 프로모터의 단백질-결합 부위에의 결합이 관심 유전자 (예를 들어, 본원에 기재된 바와 같은 화합물-생산 단백질을 코딩하는 유전자)의 발현을 촉진하도록 위치하는 단백질-결합 부위를 포함하는 프로모터에 결합할 수 있다. 비-LAL DNA 결합 도메인은 관련 기술분야에 공지되어 있는 임의의 DNA 결합 도메인을 포함할 수 있다. 일부 경우에, 비-LAL DNA 결합 도메인은 전사 인자 DNA 결합 도메인이다. 비-LAL DNA 결합 도메인의 예는, 제한 없이, 염기성 헬릭스-루프-헬릭스 (bHLH) 도메인, 류신 지퍼 도메인 (예를 들어, 염기성 류신 지퍼 도메인), GCC 박스 도메인, 헬릭스-턴-헬릭스 도메인, 호메오도메인, srf-유사 도메인, 쌍형성된 박스 도메인, 윙드 헬릭스 도메인, 아연 핑거 도메인, HMG-박스 도메인, Wor3 도메인, OB-폴드 도메인, 이뮤노글로불린 도메인, B3 도메인, TAL 이펙터 도메인, Cas9 DNA 결합 도메인, GAL4 DNA 결합 도메인, 및 관련 기술분야에 공지되어 있는 임의의 다른 DNA 결합 도메인을 포함한다. 일부 경우에, 프로모터는 관심 유전자의 상류에 위치하여, 융합 단백질이 프로모터에 결합하여 관심 유전자의 발현을 유도하거나 억제하게 할 수 있다. 특정 경우에, 프로모터는 관심 유전자를 함유하는 핵산 (예를 들어, 염색체, 플라스미드, 포스미드, 또는 관련 기술분야에 공지된 임의의 다른 핵산 구축물)에 도입된 이종 프로모터이다. 다른 경우에, 프로모터는 관심 유전자 상류에 위치하는 기존의 프로모터이다. 프로모터 내의 단백질-결합 부위는, 예를 들어, 비-LAL 단백질-결합 부위일 수 있다. 특정 실시양태에서, 단백질-결합 부위는 비-LAL DNA 결합 도메인에 결합하여, 그에 의해 동족 DNA 결합 도메인/ 단백질-결합 부위 쌍을 형성한다.
일부 실시양태에서, LAL은 서열식별번호: 180-212 중 어느 하나에 대해 적어도 70% (예를 들어, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 99%) 서열 동일성을 갖는 핵산에 의해 코딩되거나 또는 서열식별번호: 180-212 중 어느 하나에 대해 적어도 70% (예를 들어, 적어도 70%, 적어도 75%, 적어도 80%, 적어도 85%, 적어도 90%, 적어도 95%, 적어도 99%) 서열 동일성을 갖는 서열을 갖는다.
LAL 결합 부위
일부 실시양태에서, 유전자 클러스터 (예를 들어, PKS 유전자 클러스터)는 1개 이상의 LAL 결합 부위를 포함하는 1개 이상의 프로모터를 포함한다. LAL 결합 부위는 폴리뉴클레오티드 컨센서스 LAL 결합 부위 서열 (예를 들어, 본원에 기재된 바와 같은 것)을 포함할 수 있다. 일부 경우에, LAL 결합 부위는 코어 AGGGGG (서열식별번호: 213) 모티프를 포함한다. 특정 경우에, LAL 결합 부위는 서열식별번호: 213에 대해 적어도 80% (예를 들어, 80%, 85%, 90%, 95%, 97%, 98%, 99%, 또는 100%) 상동성을 갖는 서열을 포함한다. LAL 결합 부위는 컨센서스 또는 최적화된 LAL 결합 부위의 서열과 매치되도록 회복된 돌연변이 부위를 포함할 수 있다. 일부 실시양태에서, LAL 결합 부위는 합성 LAL 결합 부위이다. 일부 실시양태에서, 합성 LAL 결합 부위는 (a) 적어도 8개의 뉴클레오티드를 포함하는 복수의 합성 핵산을 제공하는 단계; (b) 적어도 8개의 뉴클레오티드를 포함하는 복수의 뉴클레오티드 중 1개 이상을 1개 이상의 LAL과 접촉시키는 단계; (c) 단계 (a)의 핵산과 단계 (b)의 LAL 사이의 결합 친화도를 결정하는 단계에 의해 확인될 수 있으며, 여기서 합성 핵산은 합성 핵산과 LAL 사이의 친화도가 X보다 더 큰 경우에 합성 LAL 결합 부위로서 확인된다. 이어서 확인된 합성 LAL 결합 부위는 숙주 세포 내로 화합물-생산 클러스터 (예를 들어, PKS 클러스터)에 도입될 수 있다.
일부 실시양태에서, 천연 쌍과 비교하여 증가된 발현을 갖는 LAL 결합 부위 및 이종 LAL 또는 이종 LAL 결합 부위 및 LAL의 쌍은 (a) 1개 이상의 LAL 결합 부위를 제공하는 단계; (b) LAL 결합 부위 중 1개 이상을 1개 이상의 LAL과 접촉시키는 단계; (c) LAL 결합 부위와 LAL 사이의 결합 친화도를 결정하는 단계에 의해 확인될 수 있으며, 여기서 증가된 발현을 갖는 쌍은 LAL 결합 부위와 LAL 사이의 친화도가 LAL 결합 부위와 그의 동종 LAL 및/또는 그의 동종 LAL 결합 부위에서의 LAL 사이의 친화도보다 더 큰 경우에 확인된다. 일부 실시양태에서, LAL 결합 부위와 LAL 사이의 결합 친화도는 LAL 및 LAL 결합 부위 둘 다를 포함하는 세포에 의한 단백질 또는 화합물의 발현을 결정함으로써 결정된다.
구성적으로 활성인 LAL
일부 실시양태에서, 재조합 LAL은 구성적으로 활성인 LAL이다. 예를 들어, LAL의 아미노산 서열은 변경된 LAL에 대한 유도제 화합물의 존재를 필요로 하지 않아 그의 동족 결합 부위에 결속하고 화합물 생산 단백질 (예를 들어, 폴리케티드 신타제)의 전사를 활성화시키는 방식으로 변형되었다. 구성적으로 활성인 LAL을 숙주 세포에 도입하는 것은 화합물-생산 단백질 (예를 들어, 폴리케티드 신타제)의 증가된 발현, 및 차례로, 상응하는 화합물 (예를 들어, 폴리케티드)의 증가된 생산을 유발할 가능성이 있을 것이다.
단방향성 LAL 조작
FK 유전자 클러스터는 LAL 결합 부위인 것으로 추정되는 보존된 (단일 또는 다중으로, 및 서로 역전되고/거나 직접 반복되는) GGGGGT (서열식별번호: 179) 모티프를 보유하는 다중 양방향성 프로모터-오퍼레이터에 의해 구동되는 멀티시스트론 구조로 배열된다. 양방향성 LAL 프로모터는 대향하는 프로모터 중 하나를 전략적으로 결실시키지만 탠덤 LAL 결합 부위는 유지시킴으로써 단방향성 LAL (UniLAL)로 전환될 수 있다 (MalT에 대해 입증된 바와 같이, 천연 프로모터 내 LAL의 결합이 협동적인 경우). 기능적으로 이것은 (-35 및 -10 프로모터 서열을 함유할 가능성이 있는) 안티센스 가닥 상에 존재하는 보존된 GGGGGT (서열식별번호: 179) 모티프의 3' 모든 서열을 제거하지만 센스 가닥 상의 전체 서열은 무손상 상태로 남겨두는 것에 의해 달성된다. 이러한 결실의 결과로서, 전사는 단지 한 방향으로만 활성화될 것이다. 이러한 피드-포워드 회로 구조의 이점은 스트렙토미세스 영양 및 발효 성장 조건의 복잡한 생활 주기 동안 LAL 발현을 조정하고/하거나 최대화하는 것일 것이다.
숙주 세포
일부 실시양태에서, 숙주 세포는 박테리아, 예컨대 악티노박테리아이다. 예를 들어, 일부 실시양태에서, 숙주 세포는 스트렙토미세스 균주이다. 일부 실시양태에서, 숙주 세포는 스트렙토미세스 아눌라투스(Streptomyces anulatus), 스트렙토미세스 안티비오티쿠스(Streptomyces antibioticus), 스트렙토미세스 코엘리콜로르(Streptomyces coelicolor), 스트렙토미세스 퓨세티우스(Streptomyces peucetius), 스트렙토미세스 종 ATCC 700974, 스트렙토미세스 카누스(Streptomyces canus), 스트렙토미세스 노도수스(Streptomyces nodosus), 스트렙토미세스 (다중 종), 스트렙토알로테이쿠스 힌두스타누스(Streptoalloteicus hindustanus), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 스트렙토미세스 아베르미틸리스(Streptomyces avermitilis), 스트렙토미세스 비리도크로모게네스(Streptomyces viridochromogenes), 스트렙토미세스 베르티실루스(Streptomyces verticillus), 스트렙토미세스 카르투르엔시스(Streptomyces chartruensis), 스트렙토미세스 (다중 종), 사카로트릭스 무타빌리스(Saccharothrix mutabilis), 스트렙토미세스 할스테디이(Streptomyces halstedii), 스트렙토미세스 클라불리게루스(Streptomyces clavuligerus), 스트렙토미세스 베네주엘라에(Streptomyces venezuelae), 스트렙토미세스 로세오크로모게네스(Strteptomyces roseochromogenes), 아미콜라톱시스 오리엔탈리스(Amycolatopsis orientalis), 스트렙토미세스 클라불리게루스(Streptomyces clavuligerus), 스트렙토미세스 리시리엔시스(Streptomyces rishiriensis), 스트렙토미세스 라벤둘라에(Streptomyces lavendulae), 스트렙토미세스 로세오스포루스(Streptomyces roseosporus), 노노무라에아(Nonomuraea) 종, 스트렙토미세스 퓨세티우스(Streptomyces peucetius), 사카로폴리스포라 에리트라에아(Saccharopolyspora erythraea), 스트렙토미세스 필리피넨시스(Streptomyces filipinensis), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 미크로모노스포라 푸르푸레아(Micromonospora purpurea), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 스트렙토미세스 나르보넨시스(Streptomyces narbonensis), 스트렙토미세스 카나미세티쿠스(Streptomyces kanamyceticus), 스트렙토미세스 콜린누스(Streptomyces collinus), 스트렙토미세스 라살리엔시스(Streptomyces lasaliensis), 스트렙토미세스 린콜넨시스(Streptomyces lincolnensis), 닥틸로스포란기움 아우란티아쿰(Dactosporangium aurantiacum), 스트렙토미세스 톡시트리시니(Streptomyces toxitricini), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 스트렙토미세스 플리카투스(Streptomyces plicatus), 스트렙토미세스 라벤둘라에(Streptomyces lavendulae), 스트렙토미세스 가나엔시스(Streptomyces ghanaensis), 스트렙토미세스 신나모넨시스(Streptomyces cinnamonensis), 스트렙토미세스 아우레오파시엔스(Streptomyces aureofaciens), 스트렙토미세스 나탈렌시스(Streptomyces natalensis), 스트렙토미세스 카타노오겐시스(Streptomyces chattanoogensis) L10, 스트렙토미세스 리디쿠스(Streptomyces lydicus) A02, 스트렙토미세스 프라디아에(Streptomyces fradiae), 스트렙토미세스 암보파시엔스(Streptomyces ambofaciens), 스트렙토미세스 텐다에(Streptomyces tendae), 스트렙토미세스 노우르세이(Streptomyces noursei), 스트렙토미세스 아베르미틸리스(Streptomyces avermitilis), 스트렙토미세스 리모수스(Streptomyces rimosus), 스트렙토미세스 웨드모렌시스(Streptomyces wedmorensis), 스트렙토미세스 카카오이(Streptomyces cacaoi), 스트렙토미세스 프리스티나에스피랄리스(Streptomyces pristinaespiralis), 스트렙토미세스 프리스티나에스피랄리스(Streptomyces pristinaespiralis), 악티노플라네스(Actinoplanes) 종 ATCC 33076, 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 레케발리에리아 아에로콜로네게네스(Lechevalieria aerocolonegenes), 아미콜라톱시스 메디테라네이(Amycolatopsis mediterranei), 아미콜라톱시스 루리다(Amycolatopsis lurida), 스트렙토미세스 알부스(Streptomyces albus), 스트렙토미세스 그리세올루스(Streptomyces griseolus), 스트렙토미세스 스펙타빌리스(Streptomyces spectabilis), 사카로폴리스포라 스피노사(Saccharopolyspora spinosa), 스트렙토미세스 암보파시엔스(Streptomyces ambofaciens), 스트렙토미세스 스타우로스포레우스(Streptomyces staurosporeus), 스트렙토미세스 그리세우스(Streptomyces griseus), 스트렙토미세스 (다중 종), 스트렙토미세스 아크로모게네스(Streptomyces acromogenes), 스트렙토미세스 추쿠바엔시스(Streptomyces tsukubaensis), 악티노플라네스 테이코미세티쿠스(Actinoplanes teichomyceticus), 스트렙토미세스 글라우세센스(Streptomyces glaucescens), 스트렙토미세스 리모수스(Streptomyces rimosus), 스트렙토미세스 카틀레야(Streptomyces cattleya), 스트렙토미세스 아주레우스(Streptomyces azureus), 스트렙토알로테이쿠스 힌두스타누스(Streptoalloteicus hindustanus), 스트렙토미세스 카르트레우시스(Streptomyces chartreusis), 스트렙토미세스 프라디아에(Streptomyces fradiae), 스트렙토미세스 코엘리콜로르(Streptomyces coelicolor), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus), 스트렙토미세스 종 11861, 스트렙토미세스 비르기니아에(Streptomyces virginiae), 아미콜라톱시스 자포니쿰(Amycolatopsis japonicum), 아미콜라톱시스 발히미시니(Amycolatopsis balhimycini), 스트렙토미세스 알부스(Streptomyces albus) J1074, 스트렙토미세스 코엘리콜로르(Streptomyces coelicolor) M1146, 스트렙토미세스 리비단스(Streptomyces lividans), 스트렙토미세스 인카르나테스(Streptomyces incarnates), 스트렙토미세스 비올라세오루베르(Streptomyces violaceoruber), 또는 스트렙토미세스 그리세오푸스쿠스(Streptomyces griseofuscus)이다. 일부 실시양태에서, 숙주 세포는 에스케리키아 균주, 예컨대 에스케리키아 콜라이(Escherichia coli)이다. 일부 실시양태에서, 숙주 세포는 바실루스 균주, 예컨대 바실루스 서브틸리스(Bacillus subtilis)이다. 일부 실시양태에서, 숙주 세포는 슈도모나스 균주, 예컨대 슈도모나스 푸티다(Pseudomonas putitda)이다. 일부 실시양태에서, 숙주 세포는 믹소코쿠스 균주, 예컨대 믹소코쿠스 크산투스(Myxococcus xanthus)이다.
실시예
실시예 1. 조작된 PKS를 생산하기 위한 단일 모듈 스와핑
모듈간 잔기 공변동 분석 및 진화적 흔적 분석을 사용하여 화합물 1을 생산하는 PKS의 모듈 3을 성공적으로 대체할 10개의 이종 공여자 모듈을 예측하였다 (도 3a). 길이가 4-6kb 범위인 10개의 예측 공여자 모듈 중 7개를 GC-풍부 긴 PCR 방법을 사용하여 그 전체로 선택적으로 증폭시켰다. 병행하여, 화합물 1을 생산하는 PKS를 보유한 박테리아 인공 염색체 (BAC)를, 제한 부위 AflII 및 SpeI을 모듈 3의 플랭킹 모듈간 서열에 도입함으로써 이종 공여자 모듈에 대한 모듈 스와프 수용자로 전환시켰다. 변형된 수용자 BAC를 AflII 및 SpeI로의 소화에 의해 선형화시키고, 7개의 공여자 모듈을 겔-정제하고, 깁슨 클로닝에 의해 서브클로닝하였다. 생성된 구축물을 관심 영역의 생어 서열분석, 클러스터 완전성을 확인하기 위한 PCR-기반 분석, 및 전체 BAC를 서열분석하기 위한 일루미나 NGS에 적용하였다. 모듈 증폭 프로토콜의 PCR-매개 오류율은 5000bp당 대략 1bp 또는 모듈당 대략 1개의 돌연변이인 것으로 결정되었다.
화합물 1을 생산하는 PKS의 모듈 3을 스트렙토미세스 균주 S317의 모듈 3으로 대체함으로써 단일 모듈을 스와핑하여 조작된 PKS를 생산하였다. 공여자 S317 모듈 3을 PCR 증폭시키고, 화합물 1을 생산하는 PKS의 위치 3 내로 깁슨 클로닝하였다 (도 3b). 생성된 클론을 스트렙토미세스 발현 숙주 내로 접합시키고, 발효시켰다. 천연 PKS의 산물인 화합물 1, 또는 조작된 PKS 클러스터에 의해 생산된 화합물인 화합물 2 중 어느 하나와 함께, 두 화합물이 결합할 것으로 예상되는 단백질인 정제된 천연 FKBP12를 공동-주입하는 것에 의한 LC-TOF 질량 분광측정법 분석에 의해 화합물의 생산을 분석하였다. 비교 LC-TOF 분석은 화합물 2가 611.38의 예상 질량을 가졌다는 것을 나타냈으며, 이는 상기 위치에서 모듈 3 알켄의 완전히 환원된 모듈로의 전환에 상응한다. 화합물 2를 대규모로 재발효시키고, 균질하게 정제하고, 구조를 NMR 분광분석법에 의해 확인하였다.
화합물 1을 생산하는 PKS 내의 모듈 4를 대체하기 위해, 모듈간 공변동에 기초한 모듈 스와핑 예측 알고리즘을 사용하여 4개의 화학을 코딩하는 16개의 모듈의 목록을 생성하였다. 모듈 4로의 깁슨-기반 서브클로닝은 모듈 3만큼 효율적이지 않았다. ssDNA 중간체를 수반하는 깁슨 클로닝은 높은 GC-풍부 영역에서 어렵고, 4bp 오버행을 갖는 제한 부위에 대한 공여자 모듈의 직접적인 라이게이션은 국부 GC 함량에 민감하지 않을 수 있다. 따라서, AflII 및 SpeI 부위를 모듈간 플랭킹 영역에서 새로운 위치에 도입하여 직접적인 라이게이션 수용자 BAC를 생성하였다. 이러한 직접적인 라이게이션 수용자 BAC를 AflII 및 SpeI로의 소화에 의해 선형화시키고, 12개의 공여자 모듈을 겔-정제하고, AfllI 및 XbaI로 소화시키고, 라이게이션에 의해 서브클로닝하였다.
화합물 1을 생산하는 PKS 내의 모듈 3 또는 모듈 4의 단일 모듈 스와프는 신규 화합물 2-5를 생성하였다 (도 3c). 따라서, 단일 모듈 스와핑을 사용하여 소정 범위의 모듈 코딩된 화학을 도입하고 신규 화합물을 생성하였다. LC-TOF 질량 분광측정법 분석은 모듈이 모듈 3 및 모듈 4에서 스와핑되어, 생성된 하이브리드 클러스터가 소정 범위의 화합물 발현을 생성하였다는 것을 나타냈다.
실시예 2. 조합 이중모듈 스와핑에 의한 라이브러리 구축
이중모듈 라이브러리의 풀링된 전달을 사용하여 화합물 1을 생산하는 PKS 내의 모듈 3 및 4를 동시에 대체하고 복수의 조작된 PKS 클러스터를 생성하였다 (도 4a). 모듈 3 위치로의 전달을 위해 총 31개의 모듈을 증폭시키고, 모듈 4 위치에 대해서는 25개의 모듈을 증폭시켰다. 깁슨 이중모듈 조립 클로닝을 최적화하기 위해서, 공여자 모듈의 PCR 증폭을 위해 포스포로티오레이트-변형된 DNA 올리고를 합성하였다. 포스포로티오에이트-캡핑된 모듈은 깁슨 클로닝 프로토콜의 엑소뉴클레아제 단계를 제약함으로써 기능이 종결되며, 이는 GC-풍부 DNA의 깁슨 포획을 극적으로 증가시켰다 (도 4b). 중간 플라스미드-기반 이중모듈 포획 프로토콜을 개발하여 이중모듈 단위를 조립, 포획, 증폭 및 풍부화시켰다 (도 4c). 풀링된 모듈 3 및 모듈 4 앰플리콘을 3-부분 깁슨 조립 반응을 위해 pBR322에 기초한 선형 백본 앰플리콘과 혼합하였다. 이중모듈 조립을 함유하는 셔틀 벡터는 정제용 0.4% 아가로스 겔 상에서 분획화함으로써 공벡터로부터 분리될 수 있었다. 이중모듈 포획 후에, 조립된 이중모듈 단편을 AfllI 및 XbaI로 소화시켜 셔틀 벡터로부터 방출시키고, 화합물 1을 생산하는 PKS (여기서 PKS는 천연 모듈 3 및 모듈 4가 결여되어 있었음)를 함유하는 발현 벡터에 직접 라이게이션시켜 서브클로닝하였다.
단일 모듈 및 이중모듈 스와프를 코딩하는 복제 BAC를 최적화된 스트렙토미세스 생산자 균주 S2441에 접합시키고, 고체상 추출된 샘플을 예상 단백질 결합 파트너인 정제된 FKBP12 단백질과 함께 LC-TOF 질량 분광측정법에 적용하였다. 추가의 분석은 이중모듈 라이브러리 생성이 신규 화합물을 고수율로 발현하는 PKS 클러스터를 조작할 수 있다는 것을 확인시켜 주었다 (도 4d). 대표적인 예로서, 화합물 6은 화합물 1을 생산한 PKS의 모듈 3에서의 mDEK 화학 및 모듈 4에서의 K 화학을 코딩하는 모듈의 이중모듈 스와핑에 의해 생성하였다. 화합물 6의 예상 질량은 LC-TOF 분석에 의해 관찰되었으며, 이는 이중모듈 조립 프로토콜이 조작된 유도체 화합물 1을 생성한다는 것을 확인시켜 준다.
화합물 1을 생산하는 PKS의 조작된 유도체의 650개-구성원 조합 라이브러리를 이중모듈 스와핑에 의해 생산하였다. 화합물 1을 생산하는 PKS의 모듈 3 위치로의 전달을 위해 총 31개의 모듈을 증폭시키고, 모듈 4 위치에 대해서는 25개의 모듈을 증폭시켰다 (도 4e). 클러스터를 BAC 상에 클로닝하고, 클로닝된 BAC를 후속적으로 다중 이종 공여자로부터의 다양한 공급원의 PCR 모듈에 대한 주형으로서 사용하였다.
모듈 3 위치에서 15개의 상이한 공여자 모듈 및 모듈 4 위치에서 15개의 상이한 공여자 모듈에 상응하는 라이브러리의 하위세트는 225개의 신규 PKS 클러스터의 잠재적인 조합 라이브러리 및 그로 인한 신규 화합물을 생산하였다 (15x15 이중모듈 라이브러리). 이중모듈 라이브러리를 풀로서 조립하였기 때문에, 라이브러리의 다양성의 >90%로 효과적으로 샘플링하기 위해 얼마나 많은 클론이 접합, 발효 및 추출될 필요가 있는지를 결정하기 위해 희박화 분석을 수행하였다. 희박화 분석은 650개의 클론이 이중모듈 라이브러리의 >90%의 통계적 샘플링에 상응한다는 것을 나타냈다 (도 4f). 650개의 클론을 취하여 LC-TOF 질량 분광측정법 분석에 적용하였다. 650개의 샘플링된 클론 중 115개는 신규 질량을 갖는 화합물을 발현하였다.
실시예 3. 단일-분자 긴-판독물 서열분석에 의한 조합 이중모듈 라이브러리의 특징화
실시예 2의 방법에 따라 생산된, 모듈 3 위치에서의 15개의 상이한 공여자 모듈 및 모듈 4 위치에서의 15개의 상이한 공여자 모듈에 상응하는 라이브러리 (15x15 이중모듈 라이브러리)를 나노포어 서열분석에 의해 특징화하였다 (도 4g). 15x15 이중모듈 라이브러리 내에 존재하는 이중모듈을 CRISPR/Cas9 (NEB)를 사용하여 PKS 클러스터로부터 절제하였다. 생성된 절제된 이중모듈 각각은 대략 7-12 킬로염기의 길이를 가졌다. 이중모듈을 96-웰 칼럼 정제에 의해 정제하고, 웰-특이적 어댑터를 이중모듈에 라이게이션시켰다. 생성된 이중모듈을 정규화하고, 풀링하고, 올리고뉴클레오티드의 나노포어 서열분석을 위한 표준 라이게이션 제조 프로토콜에 따라 서열분석하기 위해 준비하였다. 9개의 96-웰 플레이트 (총 864개의 이중모듈 클론)를 나노포어에 의해 서열분석하고, 생성된 서열분석 데이터를 도 4h에 제공된 정보 작업흐름에 따라 분석하였으며, 여기서 클론의 73.1%가 호출되었다. 공여자 모듈의 입력 표에 대한 생성된 서열분석 데이터의 비교는 생성된 이중모듈의 확인에 의한 생성된 조합 라이브러리의 디컨볼루션을 가능하게 한다. 15x15 이중모듈 라이브러리의 나노포어 서열분석의 결과가 표 1에 제공된다.
표 1.
실시예 4. 조합 삼중모듈 스와핑에 의한 라이브러리 구축
조합 모듈 스와프 프로토콜을 변형시켜 화합물 7을 생산하는 PKS 내의 삼중모듈 조립을 생성하였다 (도 5a). 모듈 스와프의 수를 증가시키는 것은 PKS 라이브러리의 크기 및 이에 따라 다양성을 증가시킨다. 예를 들어, 13개의 상이한 모듈-코딩된 화학의 수집물을 고려하여, 크기 및 다양성을 증가시키는 것은 단일 모드 스와프의 최대 라이브러리 크기가 13이고; 이중모듈 스와프의 경우 최대 라이브러리 크기가 132=169이고; 삼중모듈 스와프의 경우 최대 라이브러리가 133=2197이도록 스와핑되는 모듈의 수에 기초한다.
삼중모듈 조립은 화합물 7을 생산하는 PKS 내로 포획된 삼중모듈 조립을 삽입하기 위해 추가의 "교정" 깁슨 클로닝 단계에 의한 이중모듈 프로토콜의 기술적 진보에 영향을 미친다 (도 5b). 상기와 같이, 포스포로티오에이트 화학을 사용하여 셔틀 벡터 내로의 깁슨 클로닝의 제1 라운드를 위해 ssDNA 중간체를 제약하였다. 삼중모듈 조립을 보유하는 셔틀 벡터 클론을 정제용 겔 분획화 및 단리에 의해 풍부화시켰다. 최종적으로, 깁슨-매개 "오류 보정"을 사용하여 발현 벡터에서의 무반흔 클로닝을 위해 제한 부위를 트리밍하였다. 먼저, 플랭킹 PmeI 제한 부위를 모듈 3 및 모듈 4 사이, 뿐만 아니라 모듈 6 및 모듈 7 사이의 링커 영역 내에 도입하였다. 감소된 GC 함량 및 2차 구조를 갖는 부위 (DNA폴드에 의해 예측됨; <8 kcal/ml)를 최적 깁슨 상동성 아암을 위해 선택하였다. 깁슨 조립 울트라 키트 (SGI-DNA)를 사용하여 화합물 7을 생산하는 PKS 내로 삼중모듈 조립을 클로닝함으로써, 모듈 4, 5 및 6의 대체 및 동시에 소화 후 유지된 추가의 외래 PmeI 서열의 제거를 가능하게 하였다. 이것은 삼중모듈 스와핑된 PKS 클러스터에 의해 생산된 화합물의 산업적 규모 생산 (1주에 >200개)을 위해 >95%의 정확한 조립을 유발하였다.
실시예 5. 단일 모듈 수용자의 이중모듈 공여자로의 스와핑에 의한 고리 확장
mDEK 화학 및 K 화학을 코딩하는 이종 이중모듈 공여자 조립을 상기 기재된 방법에 의해 화합물 1을 생산하는 PKS의 단일 모듈 수용자인 모듈 3으로 스와핑하였다 (도 6a). 조작된 PKS에 의해 생산된 화합물인 화합물 8은 고수율로 관찰되었고, LC-TOF 분석에 의해 결정시 655.41의 질량을 가졌다 (도 6b). 이것은 화합물 8이 추가의 2-탄소 연장기 단위를 함유하는 고리-확장된 화합물 생성물에 상응한다. 따라서, 단일 모듈을 대체하는 이중모듈 조립의 삽입에 의한 모듈 스와핑을 통해 PKS 생합성을 재프로그램화하는 것은 기능적 PKS 발현을 가져올 수 있다.
실시예 6. PKS 로딩 모듈의 모듈 스와핑
라파마이신은 혼합된 폴리케티드 신타제 (PKS)/비리보솜 펩티드 신테타제 (NRPS) 시스템에 의해 합성된 천연 산물이다. 라파마이신은 FK506-결합 단백질 (FKBP)에 대한 결합을 담당하는 관련 천연 산물 FK506과 공통 구조적 모티프를 공유한다. 라파마이신의 생물발생 동안, 로딩 모듈은 카르복실산 리가제 (CL) 유사 도메인으로서 기능하는 CaiC 도메인을 통해 4,5-디히드록시시클로헥사-1,5-디엔카르복실산 출발 단위에 결합하고 이를 로딩한다 (도 7a). 로딩 모듈은 촉매적으로 활성일 수 있거나 그렇지 않을 수 있는, 케토리덕타제-유사 도메인 및 에노일-리덕타제 도메인을 포함한, 통상적인 신장 PKS 모듈과 유사한 도메인 구조를 보유할 수 있다. 출발 단위의 최종 화학은 로딩 모듈 내의 도메인의 존재 및 순서에 좌우되므로, 생성된 "출발 단위"는 로딩 모듈을 스와핑함으로써 조작될 수 있다.
X23 PKS 클러스터는 화합물 9 및 화합물 10을 생산한다 (도 7b). 스트렙토미세스 균주 S303으로부터의 라파마이신 로딩 모듈을 단일 모듈 스와프에 대해 이전에 기재된 방법에 의해 X23 클러스터로 스와핑하였다. 조작된 PKS는 출발 단위가 라파마이신의 출발 단위로 대체된 화합물 11 및 12를 생산하였다. X23의 모듈 2 및 모듈 7의 추가의 단일 신장 모듈 스와프는 각각 화합물 13 및 14를 생산하였다.
다른 실시예
본 개시내용이 그의 상세한 설명과 함께 기재되었지만, 상기 설명은 첨부된 청구범위의 범주에 의해 규정되는 본 개시내용의 범주를 예시하도록 의도된 것이며, 이를 제한하도록 의도된 것은 아닌 것으로 이해되어야 한다. 다른 측면, 이점 및 변경은 하기 청구범위의 범주 내에 있다.
관련 기술분야의 통상의 기술자는 본원에 기재된 본 발명에 따른 특정 실시양태에 대한 다수의 등가물을 인식하거나 또는 단지 상용 실험을 사용하여 확인할 수 있을 것이다. 본 발명의 범주는 상기 설명에 제한되는 것으로 의도되는 것이 아니라, 첨부된 청구범위에 제시된 바와 같다.
청구범위에서, 단수 용어는 달리 나타내지 않는 한 또는 문맥으로부터 달리 명백하지 않는 한, 하나 또는 하나 초과를 의미할 수 있다. 군의 하나 이상의 구성원들 사이에 "또는"을 포함하는 청구범위 또는 설명은 달리 나타내지 않는 한 또는 문맥으로부터 달리 명백하지 않는 한, 군 구성원 중 하나, 하나 초과 또는 모두가 주어진 생성물 또는 공정에 존재하거나, 그에 사용되거나, 또는 그와 달리 관련되어 있는 경우에 충족된 것으로 간주된다. 본 발명은 군의 정확하게 하나의 구성원이 주어진 생성물 또는 공정에 존재하거나, 그에 사용되거나, 또는 그와 달리 관련되어 있는 실시양태를 포함한다. 본 발명은 군 구성원 중 하나 초과 또는 모두가 주어진 생성물 또는 공정에 존재하거나, 그에 사용되거나, 또는 그와 달리 관련되어 있는 실시양태를 포함한다.
또한, 용어 "포함하는"은 개방형이도록 의도되며, 추가의 요소 또는 단계를 허용하지만 그를 필요로 하지는 않는다는 것에 유의한다. 용어 "포함하는"이 본원에 사용되는 경우에, 용어 "로 이루어진"은 그에 따라 또한 포괄되고 개시된다.
범위가 주어진 경우, 종점이 포함된다. 게다가, 달리 나타내지 않는 한 또는 문맥 및 관련 기술분야의 통상의 기술자의 이해로부터 달리 명백하지 않는 한, 범위로서 표현되는 값은 문맥이 달리 명백하게 지시하지 않는 한, 본 발명의 다양한 실시양태에서 언급된 범위 내의 임의의 구체적 값 또는 하위범위를 그 범위의 하한치의 단위의 1/10까지 가정할 수 있는 것으로 이해되어야 한다.
추가로, 선행 기술 내에 속하는 본 발명의 임의의 특정한 실시양태는 청구범위 중 어느 하나 이상으로부터 명백하게 배제될 수 있는 것으로 이해되어야 한다. 이러한 실시양태는 관련 기술분야의 통상의 기술자에게 공지된 것으로 간주되기 때문에, 배제가 본원에서 명시적으로 기재되지 않는 경우에도 배제될 수 있다. 본 발명의 조성물의 임의의 특정한 실시양태 (예를 들어, 임의의 폴리뉴클레오티드 또는 그에 의해 코딩되는 단백질; 임의의 생산 방법; 임의의 사용 방법)는 선행 기술의 존재와 관련되어 있든지 아니든지 간에, 임의의 이유로 어느 하나 이상의 청구범위로부터 배제될 수 있다.
SEQUENCE LISTING
<110> WARP DRIVE BIO, INC.
<120> COMPOSITIONS AND METHODS FOR THE PRODUCTION OF COMPOUNDS
<130> 50869-016WO2
<140> PCT/US17/58800
<141> 2017-10-27
<150> US 62/414,410
<151> 2016-10-28
<160> 204
<170> PatentIn version 3.5
<210> 1
<211> 920
<212> PRT
<213> Streptomyces malaysiensis
<400> 1
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Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
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Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Thr Val Glu Gly Gly
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Phe Leu Asp Ala Val Thr Gly Phe Asp Ala Pro Phe Phe Gly Ile Ser
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Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
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Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
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Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr
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Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala Ala
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Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
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Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu His
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Gln Ala Gly Tyr Ala Leu Arg His Gly Glu Cys Ser Leu Ala Leu Val
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Gly Gly Val Thr Val Met Ser Thr Pro Gln Thr Phe Val Glu Phe Ser
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Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ser Asp
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Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val
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Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val
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Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
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Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
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Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly
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Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
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Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
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Trp Val Asp Leu Pro Thr Tyr Ala Phe Asp His Gln Arg Tyr Trp Leu
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Arg Ala Ala Ala Val Leu Gly His Val Asp Ala Asp Ala Val Pro Val
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Ala Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
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Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
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Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
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Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
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Gly Met Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser Val Ala Val
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Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
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Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
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Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser
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Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
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Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
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Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val
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Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Ala
275 280 285
Gly Ala Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly
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Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His
355 360 365
Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu
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Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Asp Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Val Asp Thr Pro Val
420 425 430
Ser Asp Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr
435 440 445
Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr
450 455 460
Thr Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr
485 490 495
Val Thr Gly Ile Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala
515 520 525
Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Asp Leu Glu Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu
545 550 555 560
Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val
565 570 575
Arg Pro Gln Ala Val Leu Gly His Ser Val Gly Glu Val Ala Ala Gly
580 585 590
Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser
595 600 605
Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val
610 615 620
Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Val Leu Val Asp Gly
625 630 635 640
Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly
645 650 655
Asp Glu Ser Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr
660 665 670
Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met
675 680 685
Leu Glu Glu Phe Arg Gln Val Ala Ser Glu Leu Thr Tyr Arg Glu Pro
690 695 700
Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp
705 710 715 720
Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala
725 730 735
Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser
740 745 750
Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg
755 760 765
Ala Ala Val Ala Ala Leu Ala Val Met His Val Gln Gly Val Gly Val
770 775 780
Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu
785 790 795 800
Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Val Ile Gln Glu
805 810 815
Leu Ser Pro Glu Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala Met
820 825 830
Val Leu Gly His Ala Asn Ala Asp Thr Val Pro Thr Ala Thr Ala Phe
835 840 845
Gln Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser
850 855 860
Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Ala Phe Asp
865 870 875 880
Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu
885 890
<210> 4
<211> 924
<212> PRT
<213> Streptomyces malaysiensis
<400> 4
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Asp Leu Phe
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val His Gly Gly
50 55 60
Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Ser Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr
115 120 125
Gly Ile Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Ile Ala Asn Pro Gln Ile Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Asn Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Leu
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Gly Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Asp Thr Val Pro Ala Thr Leu His
355 360 365
Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Val Leu Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Asp Gln Pro Pro Ala Ser Ala Thr Asp Thr Pro
420 425 430
Ala Pro Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Lys
435 440 445
Thr Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Thr Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Thr Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp
485 490 495
Thr Val Thr Gly Thr Thr Ile Pro Asp Pro Arg Ile Val Phe Val Phe
500 505 510
Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu Leu Thr
515 520 525
Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu
530 535 540
Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser
545 550 555 560
Ile Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val Met
565 570 575
Ile Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Ile His Pro Asp Ile
580 585 590
Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Leu Ala Gly
595 600 605
Ala Ile Ser Leu Pro Asp Ala Ala Arg Ile Val Ala Gln Arg Ser Gln
610 615 620
Leu Ile Ala His Gln Leu Gly His Gly Ala Met Ala Ser Ile Ser Leu
625 630 635 640
Pro Ala Asp Asp Ile Pro Thr Thr Asp Lys Val Trp Ile Ala Ala His
645 650 655
Asn Gly Thr Ser Thr Val Ile Ala Gly Asp Pro Gln Ala Val Glu Ala
660 665 670
Ile Leu Ala Thr Cys Glu Thr Arg Gly Ala Arg Val Arg Lys Ile Asn
675 680 685
Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Thr Glu
690 695 700
Leu Leu Asp Ile Thr Thr Gly Ile Glu Ala His Thr Pro Thr Val Pro
705 710 715 720
Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu Asp Pro
725 730 735
Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly Pro Ala
740 745 750
Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile Glu Ile Ser
755 760 765
Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala Thr Thr Val Ala
770 775 780
Thr Leu Arg Arg Asp Glu Asp Thr Thr Gln Arg Leu Leu Thr Ala Phe
785 790 795 800
Ala Glu Ala His Val His Gly Ala Thr Ile Asn Trp Pro Thr Val Leu
805 810 815
Asn Thr Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg
820 825 830
Gln Arg Tyr Trp Ala Thr Ser Asn Asp Arg Leu Asn Gly Arg Thr Ser
835 840 845
Val Glu Gln His Arg Ile Met Val Glu Leu Val Leu Ala His Ala Thr
850 855 860
Ser Val Leu Gly His Glu Ser Pro Asp Ala Ile Ala Pro Asp Arg Ala
865 870 875 880
Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn
885 890 895
His Leu Val Ala Glu Thr Gly Val Arg Leu Pro Ala Thr Thr Ala Phe
900 905 910
Asp His Pro Thr Ala Asp Asp Leu Ala Lys Arg Leu
915 920
<210> 5
<211> 951
<212> PRT
<213> Streptomyces malaysiensis
<400> 5
Glu Pro Ile Ala Ile Val Ser Met Ser Cys Arg Ala Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Ser Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Asp Phe Pro Gly Asp Arg Gly Trp Asp Val Ala Gly Leu Tyr
35 40 45
Ser Pro Asp Pro Thr Gly Tyr Lys Thr Tyr Cys Val Gln Gly Gly Phe
50 55 60
Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr
85 90 95
Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Pro
100 105 110
Gly Arg Asn Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr Gly
115 120 125
Val Gly Ala Ile Asp Gln Gln Arg Asp Asn Val Ile Thr Gly Ser Ser
130 135 140
Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Cys Gln Ala Leu Arg Gln Arg Glu Cys Ser Met Ala Leu
180 185 190
Val Ser Gly Val Ser Val Ile Pro Thr Pro Asp Val Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Ser
210 215 220
Ala Ser Ala Asp Gly Thr Ile Trp Ala Glu Gly Val Gly Val Leu Val
225 230 235 240
Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Val Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
275 280 285
Thr Gly Ala Gly Leu Thr Ala Ala Asp Val Asp Val Val Glu Ala His
290 295 300
Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Ser Thr Pro Val Cys Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Ala Met Ala Ala Ser Gly Val Leu Ala Val
340 345 350
Ile Lys Met Val Glu Ala Met Arg His Gly Leu Ile Pro Arg Thr Leu
355 360 365
His Val Glu Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val
370 375 380
Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Asp Ala Lys Leu Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val
405 410 415
Val Leu Glu Gln Tyr Arg Ala Pro Ala Ala Pro Asp Ile Thr Thr Thr
420 425 430
Glu His Gln Pro Leu Ala Trp Thr Leu Ser Ala Arg Asp Pro Lys Ala
435 440 445
Leu Arg Glu Gln Ala Gly Arg Leu His Ala Ala Leu Thr Glu Ser Pro
450 455 460
Arg Trp Arg Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser
465 470 475 480
Asn Phe Ala His Arg Ala Val Ala Val Gly Ser Asp Arg Glu Leu Leu
485 490 495
Arg Ala Leu Ser Lys Leu Ala Asp Gly Ser Ala Trp Pro Ala Leu Val
500 505 510
Thr Ala Thr Ala Lys Asp Arg Arg Val Ala Tyr Leu Phe Asp Gly Gln
515 520 525
Gly Ser Gln Arg Pro Asp Met Gly Ser Gly Leu Tyr Glu Arg Phe Pro
530 535 540
Ala Phe Ala Arg Ala Trp Asp Arg Ile Ser Ala Glu Phe Gly Lys His
545 550 555 560
Leu Asp His Ser Leu Thr Asp Val Tyr Leu Gly Arg Gly Asp Ala Ala
565 570 575
Thr Ala Asp Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe
580 585 590
Thr Met Glu Ile Ala Leu Phe Glu Leu Leu Ala Glu Trp Gly Val Arg
595 600 605
Pro Asp Phe Val Ser Gly His Ser Ile Gly Glu Thr Ala Ala Ala Tyr
610 615 620
Ala Ala Gly Val Leu Ser Leu Glu Asp Val Thr Lys Leu Ile Val Ala
625 630 635 640
Arg Gly Arg Ala Leu Arg Gln Val Pro Pro Gly Ala Met Val Ala Leu
645 650 655
Arg Ala Gly Glu Asp Glu Ala Arg Glu Phe Leu Gly Arg Thr Gly Ala
660 665 670
Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Thr Ser Val Val Val Ser
675 680 685
Gly Ala Ser Glu Ala Val Ala Gly Phe Arg Ala Arg Trp Thr Glu Ser
690 695 700
Gly Arg Glu Ala Arg Thr Leu Asn Val Arg His Ala Phe His Ser Arg
705 710 715 720
His Val Glu Ala Val Leu Gly Glu Phe Arg Glu Val Leu Glu Ser Leu
725 730 735
Thr Phe Arg Thr Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly Arg
740 745 750
Leu Ile Glu Pro Thr Glu Leu Ser Thr Ser Glu Tyr Trp Leu Arg Gln
755 760 765
Val Arg Gln Thr Val Arg Phe His Asp Ala Val Arg Glu Leu Ser Gly
770 775 780
Gln Gly Val Gly Thr Phe Val Glu Ile Gly Pro Ser Gly Ala Leu Ala
785 790 795 800
Ser Ala Gly Leu Glu Cys Leu Gly Asp Glu Ala Ser Phe His Ala Val
805 810 815
Gln Arg Pro Gly Ser Pro Gly Asp Val Cys Leu Met Thr Ala Val Ala
820 825 830
Glu Leu His Ala Gly Gly Thr Thr Val Asp Trp Ala Thr Val Leu Ala
835 840 845
Gly Gly Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Gly Ser
850 855 860
Tyr Trp Leu Ala Pro Ala Arg Pro Ser Ala Pro Glu Glu Pro Arg Thr
865 870 875 880
Met Leu Glu Leu Val Arg Leu Glu Ala Ala Ile Ala Leu Ser Ile Thr
885 890 895
Asp Pro Gly Leu Ile Ala Asp Asp Ser Ser Phe Leu Asp Leu Gly Phe
900 905 910
Asp Ser Ile Ser Ala Leu Arg Leu Ser Asn Arg Leu Ala Ala Val Thr
915 920 925
Gly Leu Asp Leu Pro Pro Ser Leu Leu Phe Asp His Pro Thr Pro Ala
930 935 940
Glu Leu Ala Ala Arg Leu Asp
945 950
<210> 6
<211> 918
<212> PRT
<213> Streptomyces malaysiensis
<400> 6
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Asp Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Thr Val Leu Gly Gly
50 55 60
Phe Leu Asp Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu His Ala Gly Ile Pro Pro Arg Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Ser Gly Tyr
115 120 125
Asn Ala Gly Leu Glu Glu Phe Gly Met Thr Gly Asp Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Leu Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Leu Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Trp Gly Val Ile Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Met Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Asp Thr Val Pro Ala Thr Leu His Val Asp
355 360 365
Ala Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Glu Asn Arg Pro Trp Pro Glu Thr Gly Arg Val Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Glu Gln Pro Ala Ser Pro Pro Glu Ala Val Ala Pro Val
420 425 430
Val Ala Ser Asp Arg Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala
435 440 445
Ala Leu Ala Glu Met Glu Asn Arg Leu Arg Ala Tyr Leu Ala Ala Ala
450 455 460
Pro Gly Ala Asp Pro Arg Ala Val Ala Ser Thr Leu Ala Thr Ala Arg
465 470 475 480
Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asn Thr Ile Thr
485 490 495
Gly Thr Val Ala Gly Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly
500 505 510
Gln Gly Trp Gln Gln Leu Gly Met Gly Arg Ala Leu Arg Glu Ser Ser
515 520 525
Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu
530 535 540
Phe Val Asp Trp Asp Leu Phe Thr Met Leu Asp Asp Pro Ala Val Ile
545 550 555 560
Asp Arg Ile Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Met Ser
565 570 575
Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile
580 585 590
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu
595 600 605
Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Leu Leu
610 615 620
Ala Arg Glu Met Gly His Gly Val Met Ala Ala Val Ala Leu Pro Ala
625 630 635 640
Asp Asp Ile Pro Leu Val Asp Gly Val Trp Ile Gly Ala Arg Asn Gly
645 650 655
Pro Ser Ser Thr Val Ile Ser Gly Thr Pro Glu Ala Val Glu Val Val
660 665 670
Val Ala Ala Cys Glu Glu Arg Gly Ala Arg Val Arg Arg Ile Thr Ala
675 680 685
Ala Val Ala Ser His Ser Pro Leu Gly Glu Lys Ile Arg Thr Glu Leu
690 695 700
Leu Gly Ile Ser Ala Ser Ile Pro Ser Arg Thr Pro Val Val Pro Trp
705 710 715 720
Leu Ser Thr Ala Asp Gly Ile Trp Ile Glu Ala Pro Leu Asp Pro Ala
725 730 735
Tyr Trp Trp Arg Asn Leu Arg Glu Pro Val Gly Phe Gly Pro Ala Val
740 745 750
Asp Leu Leu Gln Ala Arg Gly Glu Asn Val Phe Leu Glu Met Ser Ala
755 760 765
Ser Pro Val Leu Leu Pro Ala Met Asn Asp Ala Val Thr Val Ala Thr
770 775 780
Leu Arg Arg Asp Asp Asp Thr Pro Asp Arg Met Leu Thr Ala Leu Ala
785 790 795 800
Glu Ala His Ala His Gly Val Ile Val Asp Trp Pro Arg Val Phe Gly
805 810 815
Ser Thr Thr Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His Gln
820 825 830
Arg Tyr Trp Ala Val Asn Gly Arg Pro Ala Asp Leu Thr Pro Glu Ala
835 840 845
Leu Leu Lys Leu Val Cys Gly Arg Ala Ala Ala Val Leu Gly His Val
850 855 860
Asp Ala Asp Ala Val Pro Val Ala Val Ala Phe Arg Asp Leu Gly Val
865 870 875 880
Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr
885 890 895
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr
900 905 910
Val Leu Ala Gly Arg Leu
915
<210> 7
<211> 890
<212> PRT
<213> Streptomyces malaysiensis
<220>
<221> misc_feature
<222> (102)..(102)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (128)..(128)
<223> Xaa can be any naturally occurring amino acid
<220>
<221> misc_feature
<222> (130)..(130)
<223> Xaa can be any naturally occurring amino acid
<400> 7
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Ala Val Arg Gly Gly
50 55 60
Phe Leu Asp Gly Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Xaa Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Xaa
115 120 125
Gly Xaa Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser Val Ala Val
130 135 140
Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Gly Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Asp Thr Val Pro Ala Thr Leu His
355 360 365
Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Asp Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Met Asp Thr Pro Val
420 425 430
Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr
435 440 445
Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr
450 455 460
Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Val
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr
485 490 495
Val Thr Gly Ile Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala
515 520 525
Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Asp Leu Glu Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu
545 550 555 560
Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val
565 570 575
Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly
580 585 590
Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser
595 600 605
Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val
610 615 620
Ala Val Pro Val Ser Glu Glu Arg Ala Arg Ala Val Leu Val Asp Gly
625 630 635 640
Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly
645 650 655
Asp Glu Ser Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr
660 665 670
Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met
675 680 685
Leu Glu Glu Phe Arg Gln Val Ala Ser Glu Leu Thr Tyr Arg Glu Pro
690 695 700
Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp
705 710 715 720
Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala
725 730 735
Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser
740 745 750
Arg Leu Ile Asp Gly Ile Pro Thr Leu His Gly Asp Asp Glu Gln His
755 760 765
Ala Val Val Ala Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile
770 775 780
Asp Trp Ser Ser Ile Leu Gly Val Asn Pro Ala Arg Val Asp Leu Pro
785 790 795 800
Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Val Ile Gln Glu Leu
805 810 815
Ser Pro Glu Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala Met Met
820 825 830
Leu Gly His Pro Asn Thr Asp Ala Ile Ala Ala Thr Thr Ala Phe Arg
835 840 845
Asp Leu Gly Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Ser Leu
850 855 860
Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr
865 870 875 880
Pro Thr Pro Thr Val Leu Ala Gly Arg Leu
885 890
<210> 8
<211> 895
<212> PRT
<213> Streptomyces malaysiensis
<400> 8
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Asp Leu Phe
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val His Gly Gly
50 55 60
Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Ile Ala Asn Pro Gln Ile Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Gly Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His
355 360 365
Ala Asp Gln Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Leu Gly Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Val Asp Thr Pro Val
420 425 430
Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr
435 440 445
Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr
450 455 460
Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Thr
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp Thr
485 490 495
Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Ile Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala
515 520 525
Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Asp Leu Asp Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu
545 550 555 560
Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val
565 570 575
Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly
580 585 590
Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser
595 600 605
Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val
610 615 620
Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Val Leu Val Asp Gly
625 630 635 640
Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly
645 650 655
Asp Glu Ala Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr
660 665 670
Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met
675 680 685
Leu Glu Glu Phe Arg Gln Val Val Ser Arg Leu Thr Tyr Arg Glu Pro
690 695 700
Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp
705 710 715 720
Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Asp Gln Val Ala Ala
725 730 735
Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser
740 745 750
Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg
755 760 765
Ala Ala Val Ala Ala Leu Ala Val Met His Val Gln Gly Val Gly Val
770 775 780
Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu
785 790 795 800
Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Ala Asn Asn Gly
805 810 815
Arg Pro Ala Asp Leu Thr Pro Glu Ala Leu Leu Lys Val Val Arg Asp
820 825 830
Ser Ala Ala Met Val Leu Gly His Ala Asn Ala Asp Thr Val Pro Ala
835 840 845
Ala Thr Ala Phe Gln Glu Leu Gly Leu Asp Ser Leu Ile Ala Val Glu
850 855 860
Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr
865 870 875 880
Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu
885 890 895
<210> 9
<211> 899
<212> PRT
<213> Streptomyces malaysiensis
<400> 9
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Phe Asp Ala
20 25 30
Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Thr Thr Leu His Gly Gly
50 55 60
Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Ala Met Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Glu Leu Gly Gly Phe Met Leu Thr Gly Arg Ala Gly
130 135 140
Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ala Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Val Met Phe Val Glu Phe Ser
195 200 205
Gln Gln Gln Asn Leu Ala Asp Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Thr
275 280 285
Ser Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Glu Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Ala Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Phe Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Pro Met Asp Thr Pro Ala
420 425 430
Pro Thr Val Thr Thr Gly Val Val Pro Leu Pro Ile Ser Ala Lys Ser
435 440 445
Leu Pro Ala Leu Ala Asp Leu Glu Asp Gln Leu Arg Ala Tyr Leu Thr
450 455 460
Ala Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr
485 490 495
Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Ile Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala
515 520 525
Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Asp Leu Asp Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu
545 550 555 560
Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val
565 570 575
Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly
580 585 590
Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser
595 600 605
Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val
610 615 620
Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Ala Leu Val Asp Gly
625 630 635 640
Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly
645 650 655
Asp Glu Ala Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr
660 665 670
Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met
675 680 685
Leu Glu Glu Phe Gly Gln Val Ala Ser Glu Leu Thr Tyr Gln Glu Pro
690 695 700
Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp
705 710 715 720
Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala
725 730 735
Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser
740 745 750
Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg
755 760 765
Ala Ala Val Ala Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile
770 775 780
Asp Trp Pro Ala Ile Leu Gly Thr Thr Thr Gly Arg Val Leu Asp Leu
785 790 795 800
Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Ala Ala Ser Thr Trp
805 810 815
Leu Ala Gly Leu Ala Pro Glu Glu Arg Glu Gly Ala Leu Met Lys Val
820 825 830
Val Arg Asp Thr Ala Ala Val Val Leu Gly His Ala Asp Ala Gly Thr
835 840 845
Ile Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr
850 855 860
Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ser Thr Gly Leu Arg Leu
865 870 875 880
Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ser Leu Ala Ala
885 890 895
Arg Leu Asp
<210> 10
<211> 867
<212> PRT
<213> Micromonospora A92-306401
<400> 10
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Ala Asp Leu Ser Leu Arg
35 40 45
Gly Gly Phe Leu Gly Asp Ala Ala His Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly
100 105 110
Gly Tyr Gly Ala Gly Ala Asp Leu Ala Gly Phe Gly Val Thr Ala Gly
115 120 125
Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Pro Thr Pro Asp Ile Phe Val Glu
180 185 190
Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe
195 200 205
Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Ala Gly Val Leu
210 215 220
Val Val Glu Arg Leu Ser Asp Ala Glu Arg Arg Gly His Thr Val Leu
225 230 235 240
Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Ala Asn Ala Gly Leu Thr Pro His Glu Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Thr Tyr Gly Arg Asp Arg Glu His Pro Leu Leu Leu Gly Ser
305 310 315 320
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly
325 330 335
Leu Ile Lys Met Val Met Ala Leu Arg Arg Gly Thr Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Gln Leu Ala Ile Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro
370 375 380
Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Asp Ser Glu Glu Pro
405 410 415
Ala Gly Leu Thr Pro Leu Leu Ile Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Ala Glu Phe Glu Asp Arg Leu Arg Ala Arg Leu Thr Thr Glu Pro Asn
435 440 445
Leu Ser Ala Val Ala Ser Thr Leu Val Arg Thr Arg Ser Leu Phe Asp
450 455 460
His Arg Ala Val Leu Leu Asp Gly Glu Thr Val Ser Gly Met Ala Glu
465 470 475 480
Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg
485 490 495
Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys
500 505 510
Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val
515 520 525
Asp Glu Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp
565 570 575
Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Glu Thr Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu
595 600 605
Glu Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu
625 630 635 640
Gln Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser
645 650 655
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
660 665 670
Ala Val Ala Glu Gln Leu Thr Tyr Gly Ser Pro Arg Ile Pro Met Ala
675 680 685
Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val
690 695 700
Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu
705 710 715 720
Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Val Asp Gly Ile Ala Val
725 730 735
Leu Asp Arg Glu Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg
740 745 750
Leu His Val Arg Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg
755 760 765
Arg Glu Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp
770 775 780
Ala Glu Thr Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu
785 790 795 800
Val Arg Asp Thr Thr Ala Thr Val Leu Gly Tyr Pro Asp Asn Thr Ala
805 810 815
Val Thr Pro Thr Thr Ala Phe Thr Asp Leu Gly Ile Asp Ser Leu Thr
820 825 830
Ala Ile Glu Leu Arg Asn Asn Met Ala Thr Thr Thr Gly Leu Arg Leu
835 840 845
Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala
850 855 860
Arg Leu Asp
865
<210> 11
<211> 901
<212> PRT
<213> Micromonospora A92-306401
<400> 11
Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Thr Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Glu Gly Gly
50 55 60
Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Asp Ala
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Ser Gly Tyr
115 120 125
Gly Ala Asp Leu Glu Gly Phe Gly Gly Thr Ala Gly Ala Leu Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ala
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ser Leu Arg His Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Gly Asp Thr Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asp Asn Ala
275 280 285
Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr
305 310 315 320
Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Ile Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val His Leu Val
370 375 380
Arg Glu Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu Glu
405 410 415
Ser Pro Pro Ser Gln Pro Ala Pro Glu Pro Ala Pro Ala Leu Ser Pro
420 425 430
Leu Val Ile Ser Ala Lys Thr Pro Gln Ala Leu Ala Ala Tyr Glu Asp
435 440 445
Arg Leu Arg Thr Tyr Leu Thr Ala Ala Pro Ser Thr Asp Ala Arg Ala
450 455 460
Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly
465 470 475 480
Glu Asp Thr Val Thr Gly Thr Ala Leu Thr Glu Pro Arg Val Val Phe
485 490 495
Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ala Ala Leu
500 505 510
Met Glu Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala
515 520 525
Leu Ser Glu Phe Val Asp Trp Asn Leu Ile Thr Val Leu Asn Asp Pro
530 535 540
Ala Val Ile Asp Gln Val Asp Val Val Gln Pro Ala Cys Trp Ala Val
545 550 555 560
Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp
565 570 575
Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
580 585 590
Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser
595 600 605
Arg Leu Ile Ser Glu Arg Leu Gly Lys Gly Ala Met Ala Ser Ile Thr
610 615 620
Leu Pro Ala Asp Gln Ile Thr Leu Ala Glu Gly Ala Trp Ile Ala Ala
625 630 635 640
Tyr Asn Gly Pro Thr Ser Thr Val Val Ala Gly Thr Pro Gln Ala Ile
645 650 655
Glu Gln Met His Gly Glu Arg Val Arg Arg Ile Ala Val Asp Tyr Ala
660 665 670
Ser His Thr Pro His Val Glu Gln Ile Arg Ala Glu Leu Leu Asp Leu
675 680 685
Thr Thr Asp Val Ser Ser Gln Thr Pro Thr Leu Pro Trp Tyr Ser Thr
690 695 700
Val Asp Gly Thr Trp Ile Asp Ser Pro Leu Asp Gly Asp Tyr Trp Tyr
705 710 715 720
Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Gln Thr Leu
725 730 735
Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro Val
740 745 750
Leu Leu Pro Ala Met Asp Asp Ala Val Thr Ile Ala Thr Leu Arg Arg
755 760 765
Asp Glu Gly Thr Leu Thr Arg Met His Thr Ala Leu Ala Glu Ala His
770 775 780
Val Leu Gly Val Thr Ile Asp Trp Pro Thr Val Leu Gly Val Thr Thr
785 790 795 800
Arg His Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp
805 810 815
Val Ala Glu Leu Ala Ser Leu Gly Pro Ala Glu Arg Glu Arg Ala Leu
820 825 830
Arg Lys Leu Val Ser Asp Thr Ala Ala Gly Ile Leu Gly His Ala Asp
835 840 845
Ser Gly Thr Val Pro Val Thr Ala Ala Phe Arg Glu Leu Gly Val Asp
850 855 860
Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly
865 870 875 880
Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Gln Ala
885 890 895
Leu Ala Asp Arg Leu
900
<210> 12
<211> 905
<212> PRT
<213> Micromonospora A92-306401
<400> 12
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Ser Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly
50 55 60
Phe Leu Ala Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ala Gly Gly Tyr
115 120 125
Gly Ala Ala Val Glu Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Gln Gly Pro Ala Ile
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Thr Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Ala Ala Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val His Leu Val
370 375 380
Thr Glu Asn Gln Pro Trp Pro Asp Thr Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Ile Glu
405 410 415
Gly Ser Pro Thr Ser Ser Pro Val Ala Glu Pro Ser Gly Asp Val Leu
420 425 430
Pro Leu Val Val Ser Ala Lys Thr Pro Gln Ala Leu Thr Ala Tyr Glu
435 440 445
Asp Arg Leu Arg Ala Phe Leu Ala Ala Ala Pro Val Thr Asp Thr Arg
450 455 460
Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg
465 470 475 480
Ala Val Leu Val Gly Asp Asn Thr Val Thr Gly Thr Ala Leu Ala Glu
485 490 495
Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly
500 505 510
Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala Glu Arg Met Ala
515 520 525
Glu Cys Ala Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu Leu Ala
530 535 540
Val Leu Asp Asp Ser Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Asp Ala
565 570 575
Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Ile
595 600 605
Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu Gly Lys Gly Ala
610 615 620
Met Ala Ser Ile Thr Leu Pro Ala Asp Gln Ile Thr Leu Ala Glu Gly
625 630 635 640
Ala Trp Ile Ala Ala Tyr Asn Gly Pro Ala Ser Thr Val Val Ala Gly
645 650 655
Thr Pro Asp Ala Ile Glu Gln Met Gln Gly Asp Arg Val Arg Arg Ile
660 665 670
Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Ala
675 680 685
Glu Leu Leu Asp Leu Thr Ala Glu Val Gly Ser Arg Thr Pro Thr Val
690 695 700
Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp Ser Pro Leu Asp
705 710 715 720
Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro
725 730 735
Ala Val Gln Thr Leu Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val
740 745 750
Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp Ala Val Thr Val
755 760 765
Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg Met His Thr Ala
770 775 780
Leu Ala Glu Ser His Val Leu Gly Val Ser Ile Asp Trp Pro His Val
785 790 795 800
Leu Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro Thr Tyr Ala Phe
805 810 815
Glu Arg His Arg Tyr Trp Ser Thr Ala Arg Arg Asn Pro Ser Ile Ala
820 825 830
Pro Asp Asp Leu Leu Thr Val Val Arg Asp Ser Ala Ala Val Val Leu
835 840 845
Gly Tyr Ala Asp Gly Gly Ala Val Pro Val Thr Gly Ala Phe Lys Asp
850 855 860
Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala
865 870 875 880
Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Val Ala Phe Asp Tyr Pro
885 890 895
Thr Pro Gln Ala Leu Ala Ala Arg Leu
900 905
<210> 13
<211> 865
<212> PRT
<213> Micromonospora A92-306401
<400> 13
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Ala Glu Tyr Ser Phe Gln
35 40 45
Gly Gly Phe Leu Asp Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Thr Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Arg Ala Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Thr Phe Val Glu
180 185 190
Phe Ser Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe
195 200 205
Ala Asp Ser Ala Asp Gly Ala Gly Phe Ala Glu Gly Ala Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His Gly His Gln Val Leu
225 230 235 240
Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Asp Asn Ala Gly Leu Thr Ala Ala Glu Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Ala Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser
305 310 315 320
Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Val Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Arg Leu Ala Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg Pro
370 375 380
Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Gly His Glu Glu Pro
405 410 415
Ala Gly Leu Thr Pro Leu Leu Ile Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Ala Glu Phe Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Ser
435 440 445
Leu Pro Ala Val Ala Ser Thr Leu Ala Arg Thr Arg Ser Leu Phe Asp
450 455 460
His Arg Ala Val Val Leu Asp Gly Asp Val Val Arg Gly Val Ala Glu
465 470 475 480
Pro Asp Arg Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg
485 490 495
Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys
500 505 510
Ile Arg Gln Gln Val Trp Asp Gln Leu Asp Ile Pro Asp Leu Pro Val
515 520 525
Asp Gln Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp
565 570 575
Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu
595 600 605
Gln Gln Ala Arg Gly Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ala Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu
625 630 635 640
Arg Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser
645 650 655
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
660 665 670
Met Val Ala Glu Arg Leu Ser Tyr Gly Ser Pro Arg Ile Ser Met Ala
675 680 685
Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Ala Val
690 695 700
Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu
705 710 715 720
Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Met
725 730 735
Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg
740 745 750
Leu His Val Gln Gly Val Lys Val Asp Trp Pro Ile Gly Ala Gly Arg
755 760 765
Arg Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ile
770 775 780
Asp Arg Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu Val
785 790 795 800
Arg Asp Thr Ala Ala Thr Val Leu Gly Tyr Pro Asp Ser Ser Ala Val
805 810 815
Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala
820 825 830
Ile Glu Leu Arg Asn Gly Met Ala Thr Thr Thr Gly Leu Arg Leu Pro
835 840 845
Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg
850 855 860
Leu
865
<210> 14
<211> 898
<212> PRT
<213> Micromonospora A92-306401
<400> 14
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Ala Glu His Ser Phe Gln
35 40 45
Gly Gly Phe Leu Asp Gly Ala Gly Asp Phe Asp Ala Pro Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Arg Val Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly
100 105 110
Gly Tyr Ala Ala Gly Ala Asp Leu Ala Gly Phe Ala Ala Thr Ala Gly
115 120 125
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu
180 185 190
Phe Ala Arg Gln Gln Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe
195 200 205
Ala Asp Asn Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu
225 230 235 240
Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Asp Asn Ala Gly Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Thr Tyr Gly Gln Thr Arg Glu Gln Pro Leu Leu Leu Gly Ser
305 310 315 320
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Gln Leu Ala Val Glu Asn Gln Pro Trp Pro Asn Thr Gly Arg Pro
370 375 380
Arg Arg Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Ile Glu Gly Ser Pro Thr Pro Ser Pro Val Ala Glu Pro Ser
405 410 415
Gly Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Pro Gln Ala Leu
420 425 430
Thr Ala Tyr Glu Asp Arg Leu Arg Thr Tyr Leu Asn Ala Thr Pro Glu
435 440 445
Ile Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu
450 455 460
Phe Glu His Arg Ala Val Leu Leu Gly Asp Asn Thr Val Ser Gly Thr
465 470 475 480
Ala Leu Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp
485 490 495
Gln Trp Leu Gly Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala
500 505 510
Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp
515 520 525
Asn Leu Ile Thr Val Leu Asn Asp Pro Ala Val Val Asp Gln Val Asp
530 535 540
Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val
545 550 555 560
Trp Gln Asp Ala Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Gln
565 570 575
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp
580 585 590
Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Gly Glu Arg Leu
595 600 605
Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro Ala Asp Glu Ile Ala
610 615 620
Leu Val Asp Glu Val Trp Val Ala Ala Tyr Asn Gly Pro Ala Ser Thr
625 630 635 640
Val Ile Ala Gly Ala Pro Asp Ala Ile Glu Gln Met Leu Gly Asp Arg
645 650 655
Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu
660 665 670
Gln Ile Arg Ala Glu Leu Leu Asp Leu Thr Ala Glu Val Ser Ser Gln
675 680 685
Ala Pro Thr Val Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp
690 695 700
Gly Pro Leu Asp Ser Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val
705 710 715 720
Gly Phe His Pro Ala Val Glu Ala Leu Gly Gly Leu Gly Glu Thr Val
725 730 735
Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp
740 745 750
Ala Val Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg
755 760 765
Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Thr Ile Asp
770 775 780
Trp Pro Ala Val Val Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro
785 790 795 800
Thr Tyr Ala Phe Gln His His Arg Tyr Trp Thr Thr Ala Thr Ala Arg
805 810 815
Leu Glu Gly Arg Thr Gly Ala Glu Lys His Arg Leu Leu Leu Asp Ile
820 825 830
Val Leu Ala Asn Ala Ala Thr Val Leu Gly His Asp Thr Ala Asp Thr
835 840 845
Ile Ala Ser Asp Lys Pro Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr
850 855 860
Ala Val Glu Leu Arg Asn Ser Leu Ala Arg Ala Thr Glu Leu Arg Leu
865 870 875 880
Pro Ala Thr Thr Ala Phe Asp Tyr Pro Thr Pro Glu Ala Leu Ala Thr
885 890 895
Arg Leu
<210> 15
<211> 867
<212> PRT
<213> Micromonospora A92-306401
<400> 15
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Pro Asp Asp Ser Arg Gln
35 40 45
Gly Gly Phe Leu Asp Asp Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Gln Ala Gly Phe Gly Thr Thr Ala Gly
115 120 125
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Gly Thr Pro Asp Ile Phe Ala Glu
180 185 190
Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Pro Phe
195 200 205
Ala Asp Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Gln Val Leu
225 230 235 240
Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala
260 265 270
Leu Ile Gln Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Ala Tyr Gly Gln Asp Arg Ala Gln Pro Leu Leu Leu Gly Ser
305 310 315 320
Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
355 360 365
Val Arg Leu Ala Thr Glu Ser Gln Pro Trp Pro Asp Thr Gly His Pro
370 375 380
Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Val Pro Glu Glu Pro Ala Asp Thr Gly Glu Pro
405 410 415
Ser Gly Leu Val Pro Leu Leu Leu Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Thr His Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Asn
435 440 445
Leu Pro Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp
450 455 460
His Arg Ala Val Leu Leu Asp Gly Asp Val Val Arg Gly Val Ala Glu
465 470 475 480
Pro Asp Arg Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg
485 490 495
Ala Gly Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Val Phe Ala Lys
500 505 510
Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val
515 520 525
Asp Glu Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp
565 570 575
Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Ser Val Ser Glu
595 600 605
Glu Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu
625 630 635 640
Gln Ala Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser
645 650 655
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
660 665 670
Met Val Ala Glu Arg Leu Ser Tyr Gly Ser Pro Gln Ile Pro Met Ala
675 680 685
Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Thr Val
690 695 700
Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Gly Ile Phe Val Glu
705 710 715 720
Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Val Asp Gly Ile Ala Val
725 730 735
Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg
740 745 750
Leu His Val Gln Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg
755 760 765
Arg Val Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp
770 775 780
Ala Thr Arg Pro Ala Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu
785 790 795 800
Val Arg Asp Thr Ala Ala Thr Val Leu Gly Tyr Pro Asp Ser Ser Ala
805 810 815
Val Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr
820 825 830
Ala Val Glu Leu Arg Asn Asn Leu Ala Thr Ser Thr Gly Leu Arg Leu
835 840 845
Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala
850 855 860
Arg Leu Asp
865
<210> 16
<211> 868
<212> PRT
<213> Micromonospora A92-306401
<400> 16
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Asp Tyr Pro Tyr Gln
35 40 45
Gly Gly Phe Leu Thr Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asn Pro Ala
85 90 95
Asp Ala Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala
100 105 110
Gly Tyr Gly Asp Asp Arg Asp Asp Ser Pro Ala Thr Ala Gly Ala Val
115 120 125
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
130 135 140
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
145 150 155 160
Gln Ala Gly Tyr Ser Leu Arg His Gly Glu Cys Ser Met Ala Leu Val
165 170 175
Gly Gly Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ala
180 185 190
Arg Gln Gly Gly Leu Ala Glu Asp Gly Arg Cys Lys Ala Phe Ala Asp
195 200 205
Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
210 215 220
Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu Ala Val
225 230 235 240
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
245 250 255
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asp
260 265 270
Asn Ala Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly
275 280 285
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
290 295 300
Thr Tyr Gly Gln Asn Arg Gln Gln Pro Leu Leu Leu Gly Ser Ile Lys
305 310 315 320
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Ile Ile
325 330 335
Lys Met Ile Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His
340 345 350
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg
355 360 365
Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg Arg
370 375 380
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Ile Ile
385 390 395 400
Leu Glu Gly Val Pro Glu Glu Pro Ala Gln Pro Asp Glu Ser Pro Glu
405 410 415
Leu Thr Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Gln
420 425 430
Phe Glu Ala Arg Leu Arg Ser Tyr Leu Thr Thr Glu Pro Ala Leu Ser
435 440 445
Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp His Arg
450 455 460
Ala Val Leu Leu Gly Gly Asp Thr Ile Thr Gly Val Ala Glu Pro Ser
465 470 475 480
Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
485 490 495
Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys Ile Arg
500 505 510
Gln Gln Val Trp Asp Leu Leu Asp Ile Pro Asp Leu Pro Val Asp Glu
515 520 525
Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe
530 535 540
Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Ile Gly His
545 550 555 560
Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp Ser Leu
565 570 575
Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala
580 585 590
Ser Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Gln Gln
595 600 605
Ala Arg Ala Val Leu Thr Asp Gly Val Glu Leu Ala Ala Val Asn Gly
610 615 620
Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Ala
625 630 635 640
Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser His Ala
645 650 655
Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg Ala Val
660 665 670
Ala Glu Gln Leu Ser Tyr Arg Ser Pro Gln Ile Pro Met Ala Val Gly
675 680 685
Asp Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe
690 695 700
Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu Leu Gly
705 710 715 720
Pro Asp Gly Ser Leu Val Arg Leu Ile Asp Gly Ile Pro Met Leu Asp
725 730 735
Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg Leu His
740 745 750
Val Arg Gly Val Asn Val Ala Trp Pro Ile Ala Ala Asp Arg Arg Glu
755 760 765
Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp Ser Thr
770 775 780
Ala Ser Leu Ser Ala Leu Ala Pro Ala Glu Arg Glu Gln Ala Leu Arg
785 790 795 800
Lys Val Val Ser Asp Ser Ser Ala Met Val Leu Gly Tyr Ala Glu Gly
805 810 815
Arg Ala Val Ala Pro Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser
820 825 830
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu
835 840 845
Arg Leu Pro Ala Thr Ile Val Phe Asp Tyr Pro Thr Pro Gly Ala Leu
850 855 860
Ala Val Arg Leu
865
<210> 17
<211> 882
<212> PRT
<213> Micromonospora A92-306401
<400> 17
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Arg Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Glu Gly Gly
50 55 60
Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Ser Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Ile Pro Gly Leu Gly Val Thr Ala Gly Ala Val
130 135 140
Ser Val Val Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Arg Arg Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Phe Gly Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Ala Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Ala Arg Gly Glu Pro Leu Leu Leu Gly Ser Ile Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Thr Arg His Val Asp Trp Thr Thr Gly Ala Val Arg
370 375 380
Leu Ala Thr Glu Asn Gln Pro Trp Pro Glu Thr Glu Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile
405 410 415
Leu Glu Gly Val Ala Ala Glu Pro Ala Gln Pro Gly Glu Ser Pro Glu
420 425 430
Leu Thr Pro Leu Leu Leu Ser Ala Lys Thr Pro Ala Ala Leu Thr His
435 440 445
Leu Glu Asp Arg Leu Arg Ala Tyr Leu Thr Thr Glu Pro Asn Leu Pro
450 455 460
Ala Val Ala Ser Thr Leu Ala Gln Thr Arg Ser Leu Phe Asp His Arg
465 470 475 480
Ala Val Leu Leu Gly Gly Glu Thr Val Thr Gly Val Ala Glu Pro Asp
485 490 495
Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
500 505 510
Met Gly Asp Asp Leu Ala Ala Ala Phe Pro Ala Phe Ala Lys Ile Arg
515 520 525
Gln Gln Val Trp Asp Gln Leu Asp Ile Pro Asn Leu Pro Val Asp Glu
530 535 540
Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe
545 550 555 560
Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Leu Val Gly His
565 570 575
Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Ile Trp Ser Leu
580 585 590
Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala
595 600 605
Leu Pro Pro Gly Gly Val Met Val Ala Val Ser Val Ser Glu Glu Gln
610 615 620
Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly
625 630 635 640
Pro Ala Ser Val Val Leu Ser Gly Glu Glu Thr Ala Val Leu Gln Ala
645 650 655
Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Ala Thr Ser His Ala
660 665 670
Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg Ala Val
675 680 685
Ala Glu Gln Leu Ser Tyr Gly Ser Pro Arg Ile Pro Met Ala Val Gly
690 695 700
Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe
705 710 715 720
Gly Glu Gln Val Ala Ala His Asp Gly Ala Ile Phe Val Glu Leu Gly
725 730 735
Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Val Leu Asp
740 745 750
Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Arg Leu His
755 760 765
Val Arg Gly Val Lys Val Asp Trp Pro Ile Ala Ala Gly Arg Arg Glu
770 775 780
Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp Ile Asp
785 790 795 800
Ser Arg Pro Thr Ala Arg Arg Ala Pro Thr Asp Leu Leu Thr Leu Val
805 810 815
Arg Asp Thr Thr Ala Thr Val Leu Gly Tyr Pro Asp Asn Thr Ala Val
820 825 830
Thr Pro Thr Thr Ala Phe Thr Asp Leu Gly Ile Asp Ser Leu Thr Ala
835 840 845
Ile Glu Leu Arg Asn Asn Met Ala Thr Thr Thr Gly Leu Arg Leu Pro
850 855 860
Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg
865 870 875 880
Leu Asp
<210> 18
<211> 897
<212> PRT
<213> Micromonospora A92-306401
<400> 18
Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Thr Pro Glu Asp Leu Trp Gln Leu Val Glu Thr Gly Thr Asp Ala
20 25 30
Ile Ser Ala Leu Pro Thr Asp Arg Gly Trp Ala Asp His Pro Tyr Gln
35 40 45
Gly Gly Phe Leu Thr Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile
65 70 75 80
Leu Glu Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asn Pro Ala
85 90 95
Asp Ala His Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Thr Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg His Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Ile Phe Val Glu
180 185 190
Phe Ala Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe
195 200 205
Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Arg Val Leu
225 230 235 240
Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Asp Asn Ala Gly Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu
290 295 300
Ile Ala Thr Tyr Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser
305 310 315 320
Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Lys Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Arg Leu Leu Thr Glu Ser Gln Pro Trp Pro Asp Thr Asp Arg Pro
370 375 380
Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Ile Glu Gly Ser Pro Thr Pro Ser Pro Val Ala Asp Pro Ser
405 410 415
Gly Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Ala Ala Tyr Glu Asp Arg Leu Arg Thr Tyr Leu Asn Ala Thr Pro Glu
435 440 445
Ile Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Leu
450 455 460
Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp Thr Val Ser Gly Thr
465 470 475 480
Ala Leu Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp
485 490 495
Gln Trp Leu Gly Met Gly Ala Ala Leu Met Glu Ser Val Val Phe Ala
500 505 510
Glu Arg Met Thr Glu Cys Ala Thr Ala Leu Ser Glu Phe Val Asp Trp
515 520 525
Asn Leu Ile Thr Val Leu Asn Asp Pro Ala Val Ile Asp Gln Val Asp
530 535 540
Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val
545 550 555 560
Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln
565 570 575
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp
580 585 590
Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu
595 600 605
Gly Lys Gly Ala Met Ala Ser Ile Thr Leu Pro Ala Asp Gln Ile Thr
610 615 620
Leu Ala Glu Gly Ala Trp Ile Ala Ala Tyr Asn Gly Pro Thr Ser Thr
625 630 635 640
Val Val Ala Gly Thr Pro Gln Ala Ile Glu Gln Met His Gly Glu Arg
645 650 655
Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu
660 665 670
Gln Ile Arg Ala Glu Leu Leu Asp Leu Thr Thr Asp Val Ser Ser Gln
675 680 685
Thr Pro Thr Leu Pro Trp Tyr Ser Thr Val Asp Gly Thr Trp Ile Asp
690 695 700
Ser Pro Leu Asp Gly Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val
705 710 715 720
Gly Phe His Pro Ala Val Gln Thr Leu Gln Ala Leu Gly Glu Thr Val
725 730 735
Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp
740 745 750
Ala Val Thr Ile Ala Thr Leu Arg Arg Asp Glu Gly Thr Leu Thr Arg
755 760 765
Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Thr Ile Asp
770 775 780
Trp Pro His Val Leu Gly Asp Thr Gly Glu Arg Met Leu Asp Leu Pro
785 790 795 800
Thr Tyr Ala Phe Gln His His Arg Tyr Trp Thr Thr Ala Ala Arg Leu
805 810 815
Thr Gly Arg Thr Thr Ala Ala Gln His Arg Leu Met Leu Asp Phe Val
820 825 830
Leu Gly Asn Val Ala Ala Val Leu Gly His Gly Ser Ala Gly Asp Val
835 840 845
Ala Pro Asp Lys Pro Phe Lys Glu Leu Gly Met Asp Ser Leu Thr Ser
850 855 860
Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Gln Arg Leu Pro
865 870 875 880
Ala Thr Ile Val Phe Asp His Pro Thr Ala Asp Ala Leu Ala Thr Tyr
885 890 895
Leu
<210> 19
<211> 945
<212> PRT
<213> Micromonospora A92-306401
<400> 19
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Glu Phe Pro Gly Asp Arg Gly Trp Asp Val Ala Asn Leu Tyr
35 40 45
Ser Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Leu Gln Gly Gly
50 55 60
Phe Leu Asp Gly Ala Ala Ala Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Val Glu Arg Ala Arg Ile Asp Pro Lys Ser Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Leu Gly Ala Ala Glu Ala Gln Arg Asp Asn Leu Ile Thr Gly Gly
130 135 140
Ser Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu
145 150 155 160
Gly Pro Gly Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Leu Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
180 185 190
Leu Val Ser Gly Val Ser Val Met Pro Thr Pro Asp Val Phe Val Glu
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe
210 215 220
Ala Ala Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Leu Leu Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Glu Ile Leu
245 250 255
Ala Val Val Arg Gly Thr Ala Val Asn Ser Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Ser Ala Gly Leu Gly Pro Ala Asp Val Asp Ala Val Glu Ala
290 295 300
His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile
305 310 315 320
Leu Ala Thr Tyr Gly Lys Asp Arg Pro Thr Pro Val Trp Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly
340 345 350
Val Ile Lys Met Val Glu Ser Met Arg His Gly Val Leu Pro Arg Thr
355 360 365
Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ala Gly Asp
370 375 380
Val Ala Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala Gly Arg Lys Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His
405 410 415
Val Val Leu Glu Gln Tyr Arg Met Pro Ala Ala Pro Val Thr Thr Lys
420 425 430
Glu Ala Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Thr Pro Glu Ala
435 440 445
Leu Arg Glu Arg Ala Gly Gln Leu Ala Thr Ala Leu Ala Gly Asp Pro
450 455 460
Ala Trp His Pro Leu Asp Val Gly Tyr Ser Leu Ala Ala Thr Arg Ser
465 470 475 480
Thr Phe Ala His Arg Ala Val Val Val Gly Gly Asp Arg Glu Phe Val
485 490 495
Arg Thr Leu Gly Lys Leu Ala Asp Gly Ala Gly Trp Pro Gly Leu Thr
500 505 510
Thr Gly Val Ala Lys Ser Arg Arg Ile Ala Phe Met Phe Asp Gly Gln
515 520 525
Gly Thr Gln Arg Leu Ala Met Gly Gln Gly Leu Tyr Ala Arg Phe Pro
530 535 540
Ala Phe Thr Arg Thr Trp Asp Thr Val Ser Ala Glu Phe Ala Lys His
545 550 555 560
Leu Asp His Thr Leu Thr Asp Val Tyr Leu Gly Gly Gly Gly Thr Ala
565 570 575
Ala Ala Glu Leu Val Asp Asp Pro Leu Tyr Ala Gln Ala Gly Ile Phe
580 585 590
Ala Val Glu Val Ala Leu Val Glu Leu Leu Ala Glu Trp Gly Val Arg
595 600 605
Pro Asp Val Val Thr Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr
610 615 620
Thr Ala Gly Met Phe Ser Leu Ala Asp Val Thr Ala Leu Ile Thr Ala
625 630 635 640
Arg Gly Ala Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Leu Ala Leu
645 650 655
Arg Ala Gly Glu Pro Glu Val Arg Asp Phe Leu Asp Arg Thr Gly Ala
660 665 670
Ala Leu Asp Val Ala Ala Val Asn Gly Pro Ala Ala Val Val Val Ser
675 680 685
Gly Ala Pro Asp Ala Val Ala Gly Phe Ala Ser Ala Trp Thr Ala Ser
690 695 700
Gly Arg Glu Cys Arg Gln Leu Lys Val Arg Arg Ala Phe His Ser Arg
705 710 715 720
His Val Glu Gly Val Leu Gly Asp Phe Arg Thr Val Leu Lys Ser Leu
725 730 735
Thr Phe Arg Thr Pro Ala Leu Pro Ile Val Ser Thr Val Thr Gly Arg
740 745 750
Leu Ile Asp Pro Ala Glu Met Gly Thr Pro Glu Tyr Trp Leu Ser Gln
755 760 765
Val Arg Gln Pro Val Arg Phe Gln Asp Ala Val Gly Glu Leu Ala Gly
770 775 780
Gln Gly Val Ser Ala Phe Leu Glu Val Gly Pro Ser Gly Thr Leu Ala
785 790 795 800
Ser Ala Gly Met Glu Cys Leu Asp Ala Ser Phe His Ala Leu Leu Arg
805 810 815
Pro Arg Pro Ala Glu Asp Ile Gly Val Leu Thr Ala Leu Ala Glu Leu
820 825 830
Tyr Ala Gly Gly Thr Ala Val Asp Trp Ala Thr Val Leu Ala Gly Gly
835 840 845
Arg Pro Val Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr Trp
850 855 860
Leu Arg Ser Ala Pro Asp Glu Pro Arg Thr Val Leu Glu Met Val His
865 870 875 880
Leu Glu Val Ala Ser Ile Leu Gly Ile Thr Asp Pro Asp Ala Val Gln
885 890 895
Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Ser Gly Val
900 905 910
Arg Leu Arg Asn Arg Leu Thr Gln Val Thr Gly Leu Thr Leu Pro Ala
915 920 925
Thr Leu Leu Phe Asp His Asp Thr Pro Ser Ala Leu Ala Thr Glu Leu
930 935 940
Asp
945
<210> 20
<211> 907
<212> PRT
<213> Streptomyces kanamyceticus
<400> 20
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Thr Ser Pro Glu Glu Leu Trp Glu Leu Val Glu Asp Gly Gly Asp Ala
20 25 30
Val Gly Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Ala Ala Leu His
35 40 45
Ala Ala Ala Glu Ser Ala Thr Ser Arg Ala Gly Ala Leu Met Gly Ala
50 55 60
Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Thr
65 70 75 80
Ala Leu Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala Trp Glu Ala
85 90 95
Ile Glu Arg Ala Gly Ile Lys Ala Asp Val Leu Arg Gly Thr Asp Thr
100 105 110
Gly Val Phe Val Gly Gly Phe Tyr Tyr Gly Tyr Gly Ala Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Ala Tyr Ser Thr Gln Pro Ala Val Leu Ala Gly
130 135 140
Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Gln Ala
165 170 175
Leu Arg Ala Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val
180 185 190
Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln Gly Gly Val
195 200 205
Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr
210 215 220
Gly Phe Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Glu Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser Ala Pro Asn Gly Pro
260 265 270
Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Gly Ser Ala Gly Leu Ala
275 280 285
Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly
305 310 315 320
Arg Glu Val Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
325 330 335
Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala
340 345 350
Met Arg Arg Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser
355 360 365
Ser His Val Asp Trp Thr Thr Gly Ala Val Glu Leu Leu Thr Glu Ala
370 375 380
Arg Pro Trp Pro Glu Ser Asp Arg Pro Arg Arg Ala Gly Val Ser Ala
385 390 395 400
Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Val Ala
405 410 415
Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly Leu Val Pro Leu Pro
420 425 430
Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val Gln Val Glu Arg Leu
435 440 445
Gly Ala Tyr Val Arg Ser Gly Ala Asp Leu Ser Ala Val Ala Asp Gly
450 455 460
Leu Val Arg Glu Arg Val Val Phe Gly His Arg Ala Val Leu Leu Gly
465 470 475 480
Glu Ser Thr Val Ala Gly Val Ala Glu Gly Glu Leu Arg Thr Val Phe
485 490 495
Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu
500 505 510
Met Gly Ala Ser Glu Val Phe Ala Ala Arg Met Arg Glu Cys Ala Ala
515 520 525
Ala Leu Glu Pro His Thr Gly Trp Asp Leu Leu Asp Val Leu Gly Glu
530 535 540
Ala Val Val Ala Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala
545 550 555 560
Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala His Gly Gly Thr Pro
565 570 575
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Ser Val
580 585 590
Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Ile Val Ala Leu Arg
595 600 605
Ser Gln Thr Ile Ala Ala Arg Leu Gly Arg Gly Ala Met Ala Ser Ile
610 615 620
Ala Ile Pro Ser Ala Glu Val Glu Val Met Glu Gly Val Trp Val Ala
625 630 635 640
Ala Arg Asn Gly Pro Ser Ser Thr Val Ile Ala Gly Asp Pro Ala Ala
645 650 655
Val Glu Gln Val Leu Ala Arg Tyr Glu Ala Glu Gly Val Arg Val Arg
660 665 670
Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile
675 680 685
Gln Asp Glu Leu Ala Glu Val Leu Glu Gly Val Thr Ala Gln Val Pro
690 695 700
Thr Ile Pro Trp Trp Ser Thr Val Asp Ser Asp Trp Val Thr Glu Pro
705 710 715 720
Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Met
725 730 735
Asp Thr Ala Ile Gly Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser
740 745 750
Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Glu Arg Thr Val Ala
755 760 765
Ser Leu Arg Thr Asp Asp Gly Gly Trp Glu Arg Phe Leu Thr Ala Leu
770 775 780
Ala Glu Ala Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Ile Leu Val
785 790 795 800
Glu Pro Ala Pro His Arg Leu Asp Leu Pro Thr Tyr Pro Phe Asp His
805 810 815
Lys Arg Tyr Trp Leu Leu Glu Arg Leu Gly Ala Met Thr Gly Ala Asp
820 825 830
Arg Asp Ala Ala Leu Leu Thr Leu Val Arg Asp Cys Ala Ala Ala Val
835 840 845
Leu Gly His Val Asp Ala Ala Gly Val Pro Ala Asp Ala Ala Phe Lys
850 855 860
Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu
865 870 875 880
Ala Ala Ala Thr Gly Val Arg Leu Pro Ala Thr Leu Ala Phe Asp His
885 890 895
Pro Thr Pro Arg Ala Ile Ala Ser Arg Leu Asp
900 905
<210> 21
<211> 905
<212> PRT
<213> Streptomyces kanamyceticus
<400> 21
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Gly Asp Leu Trp Gln Met Leu Asp Ser Gly Gly Asp Ala
20 25 30
Val Thr Gly Phe Pro Val Asp Arg Gly Trp Asp Pro Ser Gly Leu Thr
35 40 45
Gly Gly Pro Asp Ala Asp Arg Gly Gly Phe Leu Ser Asp Ala Ala Asp
50 55 60
Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met
65 70 75 80
Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Thr Trp Glu Ala Phe Glu
85 90 95
Asn Ala Gly Ile Val Pro Gly Thr Leu Arg Gly Ser Asp Thr Gly Val
100 105 110
Phe Met Gly Ala Phe Ser Tyr Gly Tyr Gly Val Gly Ala Asp Leu Gly
115 120 125
Gly Phe Gly Ser Ile Gly Val Gln Pro Ser Val Leu Thr Gly Arg Ile
130 135 140
Ser Tyr Phe Tyr Gly Leu Gln Gly Pro Ala Phe Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg
165 170 175
His Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala
180 185 190
Asn Pro Asp Gly Phe Val Glu Phe Glu Gln Gln Gly Gly Leu Ser Pro
195 200 205
Asp Gly Arg Cys Arg Ala Phe Ala Asp Ala Ala Asn Gly Thr Gly Trp
210 215 220
Ala Glu Gly Ala Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Glu
225 230 235 240
Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn
245 250 255
Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln
260 265 270
Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Gly Ala Ala
275 280 285
Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp
290 295 300
Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Gly Arg Glu
305 310 315 320
Val Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln
325 330 335
Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Met Arg
340 345 350
Arg Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Ser His
355 360 365
Val Asp Trp Thr Ala Gly Ala Val Glu Val Val Thr Glu Ala Arg Pro
370 375 380
Trp Pro Glu Ser Gly Arg Val Pro Arg Ala Gly Val Ser Ser Phe Gly
385 390 395 400
Val Ser Gly Thr Asn Ala His Val Val Leu Glu Gly Ala Pro Glu Pro
405 410 415
Ser Ser Gly Ala Glu Ala Ser Ser Gly Gly Gly Leu Val Pro Leu Pro
420 425 430
Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Val Gln Val Glu Arg Leu
435 440 445
Gly Ala Tyr Val Arg Gly Gly Ala Asp Leu Gly Ala Val Ala Asp Gly
450 455 460
Leu Val Arg Gly Arg Ala Val Phe Asp Arg Arg Ala Val Leu Leu Gly
465 470 475 480
Glu Ser Thr Val Ala Gly Val Ala Val Glu Gly Ala Arg Thr Val Phe
485 490 495
Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly Met Gly Arg Glu Leu
500 505 510
Met Gly Val Ser Glu Val Phe Ala Ala Arg Met Arg Glu Cys Ala Ala
515 520 525
Ala Leu Glu Pro Tyr Thr Gly Trp Asp Val Leu Asp Val Leu Gly Glu
530 535 540
Ala Val Val Ala Asp Arg Val Glu Val Leu Gln Pro Ala Ser Trp Ala
545 550 555 560
Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala His Gly Val Val Pro
565 570 575
Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
580 585 590
Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Val Val Ala Leu Arg
595 600 605
Ser Gln Thr Ile Ala Ala Arg Leu Gly His Gly Ala Met Ala Ser Ile
610 615 620
Ala Leu Pro Ala Ser Ala Val Glu Val Met Glu Gly Val Trp Ile Ala
625 630 635 640
Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala Gly Asp Pro Ala Ala
645 650 655
Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala Gly Val Arg Val Arg
660 665 670
Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Ile
675 680 685
Gln Asp Glu Leu Ala Asp Val Leu Gly Gly Ile Thr Ser Ser Ala Pro
690 695 700
Asp Ile Ser Trp Trp Ser Thr Val Asp Ser Gly Trp Val Thr Glu Ala
705 710 715 720
Val Gly Asp Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Ala Met
725 730 735
Asp Thr Ala Val Ser Glu Leu Asp Gly Ser Leu Phe Ile Glu Cys Ser
740 745 750
Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln Glu Arg Thr Val Ala
755 760 765
Ser Leu Arg Thr Asp Asp Gly Gly Trp Asp Arg Phe Leu Thr Ala Leu
770 775 780
Ala Gln Ala Trp Thr Gln Gly Ala Asp Val Asp Trp Thr Thr Leu Ile
785 790 795 800
Glu Pro Ala Gln His Arg Leu Asp Leu Pro Thr Tyr Pro Phe Asp His
805 810 815
Lys Arg Tyr Trp Leu Gln Pro Ala Gly Ala Arg Asn Glu Val Ala Arg
820 825 830
His Thr Asp Leu Leu Thr Leu Val Arg Gln Lys Ala Ala Ala Leu Leu
835 840 845
Gly His Ala Gly Pro Glu Asp Val Pro Glu Asp Ala Ala Phe Arg Gln
850 855 860
Leu Gly Val Asp Ser Leu Ile Ala Val Gln Leu Arg Asn Gly Leu Asn
865 870 875 880
Glu Ala Thr Gly Leu Arg Leu Ser Ala Thr Leu Val Phe Asp Tyr Pro
885 890 895
Thr Pro Arg Ala Leu Ala Gly Arg Ile
900 905
<210> 22
<211> 913
<212> PRT
<213> Streptomyces kanamyceticus
<400> 22
Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Val Gly Arg Ser Thr Thr Arg His Gly Gly
50 55 60
Phe Leu Thr Glu Ala Thr Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Asn Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Val Pro Asp Thr Leu
100 105 110
Arg Glu Ser Asp Thr Gly Val Phe Met Gly Ala Phe His Gln Gly Tyr
115 120 125
Gly Ala Gly Arg Asp Leu Gly Gly Leu Gly Val Thr Ala Thr Gln Thr
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Gln Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ala Gln Ala Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Ala
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gly Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ser Ala Asp Gly Thr Gly Phe Ala Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Val Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Asn Gly Thr Asp Val Asp Ala Val Glu Ala His Gly
290 295 300
Thr Gly Thr Val Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Glu Arg Glu Val Pro Leu Leu Leu Gly Ser Val Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile
340 345 350
Lys Met Val Met Ala Met Arg Arg Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Ser Ser Ser His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Val Val Thr Glu Ala Arg Pro Trp Pro Glu Ser Gly Gly Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Gly Val Ala Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Ala
420 425 430
Gly Leu Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala
435 440 445
Leu Gln Val Glu Arg Leu Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu
450 455 460
Gly Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Gly Arg
465 470 475 480
Arg Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala Val Glu
485 490 495
Gly Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Val
500 505 510
Gly Met Gly Arg Glu Leu Met Gly Val Ser Glu Val Phe Ala Ala Arg
515 520 525
Met Arg Glu Cys Ala Ala Ala Leu Glu Pro His Thr Gly Trp Asp Val
530 535 540
Leu Asp Val Leu Gly Glu Ala Val Val Ala Asp Arg Val Glu Val Leu
545 550 555 560
Gln Pro Ala Ser Trp Ala Val Ala Val Ser Leu Ala Ala Leu Trp Gln
565 570 575
Ala His Gly Val Val Pro Asp Ala Val Val Gly His Ser Gln Gly Glu
580 585 590
Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala
595 600 605
Arg Val Val Ala Leu Arg Ser Gln Thr Ile Ala Ala Arg Leu Gly His
610 615 620
Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Met
625 630 635 640
Glu Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val
645 650 655
Ala Gly Asp Pro Ala Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala
660 665 670
Ala Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr
675 680 685
Pro His Val Glu Ala Ile Gln Asp Glu Leu Ala Asp Val Leu Gly Gly
690 695 700
Ile Thr Ser Ser Ala Pro Ser Val Pro Trp Trp Ser Thr Val Asp Ser
705 710 715 720
Gly Trp Val Thr Glu Pro Val Asp Asp Asp Tyr Trp Tyr Arg Asn Leu
725 730 735
Arg Gln Pro Val Ala Met Asp Thr Ala Thr Gly Glu Leu Asp Gly Ser
740 745 750
Leu Phe Ile Glu Cys Ser Ala His Pro Val Leu Leu Pro Ala Leu Asp
755 760 765
Gln Glu Arg Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Gly Trp Glu
770 775 780
Arg Phe Leu Thr Ala Leu Ala Glu Ala Trp Thr Gln Gly Ala Asp Val
785 790 795 800
Asp Trp Thr Thr Leu Ile Glu Pro Ala Gln His Arg Val Asp Leu Pro
805 810 815
Thr Tyr Pro Phe Asp His Lys Arg Tyr Trp Leu Gln Pro Ala Arg Arg
820 825 830
Thr Val Arg Thr Gly Glu Asp Ser Gly Arg Asp Leu Leu Ala Val Val
835 840 845
Cys Gly Ala Thr Ala Ala Val Leu Gly His Ala Asp Ala Ser Glu Ile
850 855 860
Gly Pro Ala Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Ser Gly
865 870 875 880
Ile Arg Leu Arg Asn Ser Leu Ala Glu Thr Thr Gly Val Arg Leu Ser
885 890 895
Ala Thr Ala Val Phe Asp His Pro Thr Pro Asp Ala Leu Ala Ala Arg
900 905 910
Leu
<210> 23
<211> 928
<212> PRT
<213> Streptomyces kanamyceticus
<400> 23
Glu Pro Leu Ala Ile Val Ala Met Ala Cys Arg Met Pro Gly Gly Val
1 5 10 15
Asp Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Leu Ala Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ile Gly Lys Val Ser Val Arg His Gly Gly
50 55 60
Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Glu Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Leu Pro Ala Ser Val
100 105 110
Arg Gly Ser Asp Ala Gly Val Phe Met Gly Ala Phe Thr Gln Gly Tyr
115 120 125
Gly Ala Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr Pro Thr
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Tyr Phe Gly Leu Glu Gly Pro
145 150 155 160
Ser Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ala Arg Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Thr Thr Gly Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Ala Asp
210 215 220
Thr Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Val Leu Ile Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Thr Arg Leu Gly His Pro Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ala Gln Arg Arg Val Ile Glu Arg Ala Leu Asp
275 280 285
Asp Ala Gly Leu Val Pro Gly Asp Ile Asp Ala Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Glu Ala
305 310 315 320
Ala Tyr Gly Leu Asp Arg Val His Pro Leu Leu Ile Gly Ser Leu Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile
340 345 350
Lys Met Val Leu Ala Met Arg His Gly Val Leu Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Gly Gly Gly Val Arg Leu
370 375 380
Leu Arg Arg Asn Glu Pro Trp Pro Val Thr Gly Arg Val Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Ala Asn Ala His Val Val Ile
405 410 415
Glu Ala Gly Pro Pro Ala Ala Pro Ala Thr Leu Pro Ala Thr Glu Pro
420 425 430
Val Pro Glu Gly Val Val Trp Pro Val Ser Ala Arg Thr Pro Asp Gly
435 440 445
Val Arg Asp Val Ala Gly Arg Leu Val Ala Leu Thr Ala Pro Ala Ala
450 455 460
Ala Ile Gly His Ser Leu Ala Thr Thr Arg Thr Ala Met Arg His Arg
465 470 475 480
Ala Val Val Pro Ala Arg Asp Ala Glu Ala Phe Ala Arg Gly Glu Glu
485 490 495
Val Pro Gly Val Val Arg Gly Thr Ala Asp Val Thr Asp Ala Arg Ala
500 505 510
Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Asp Gly Met Gly Ala
515 520 525
Glu Leu Leu Ala Thr Glu Pro Val Phe Ala Arg Arg Leu Gly Glu Cys
530 535 540
Ala Glu Ala Leu Ala Pro Tyr Thr Gly Trp Asp Leu Leu Asp Val Ile
545 550 555 560
Ala Arg Arg Pro Gly Ala Pro Ala Leu Asp Arg Val Asp Val Val Gln
565 570 575
Pro Val Ser Phe Ala Met Met Val Ala Leu Ala Glu Leu Trp Arg Ser
580 585 590
Arg Gly Val Ala Pro Ala Ala Val Val Gly His Ser Gln Gly Glu Val
595 600 605
Ala Ala Ala Cys Val Ala Gly Val Leu Thr Leu Asp Asp Ala Ala Lys
610 615 620
Val Val Ala Leu Arg Ser Arg Leu Val Ala Thr Glu Leu Gly His Gly
625 630 635 640
Gly Met Val Ser Val Pro Pro Ala Asp Phe Asp Ala Ala Ala Trp Ala
645 650 655
Gly Arg Leu Glu Val Ala Ala Val Asn Gly Pro Ala Ser Ile Val Val
660 665 670
Ala Gly Ala Ala Asp Ala Val Glu Glu Leu Leu Ala Ala Thr Pro His
675 680 685
Ala Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Ala His Val Glu
690 695 700
Thr Ile Arg Asp Ala Leu Leu Asp Ala Leu Ala Asp Leu Thr Pro Gly
705 710 715 720
Ala Pro Glu Val Pro Phe Phe Ser Thr Val Asp Glu Ala Trp Leu Asp
725 730 735
Arg Pro Ala Asp Ala Ala Tyr Trp Tyr Asp Asn Val Arg Arg Pro Val
740 745 750
Arg Phe Gly Ala Ala Thr Ala Arg Leu Ala Glu Leu Gly Tyr Arg Val
755 760 765
Phe Val Glu Ala Ser Pro His Pro Val Leu Thr Thr Ala Leu Ala Asp
770 775 780
Thr Leu Ala Gly His Pro Asn Thr Ala Val Thr Gly Thr Leu Arg Arg
785 790 795 800
Gly Asp Gly Gly Ala Arg Arg Phe Thr Ser Ser Leu Ala Glu Leu Trp
805 810 815
Val Arg Gly Val Pro Val Ser Trp Pro Ser Gly Glu Ser Arg Arg Val
820 825 830
Pro Leu Pro Thr Tyr Pro Phe Arg Arg Asp Arg Tyr Trp Ile Asp Ala
835 840 845
Glu Ala Ala Pro Thr Ala Ala Arg Asp Met Leu Glu Leu Val Arg Thr
850 855 860
Ser Ala Ala Leu Val Leu Gly His Arg Asp Ala His Ala Ile Glu Pro
865 870 875 880
Thr Arg Ala Phe Lys Glu Val Gly Phe Asp Ser Leu Thr Gly Val Glu
885 890 895
Leu Arg Asn Arg Leu Ala Asp Ala Thr Gly Leu Thr Leu Pro Ala Thr
900 905 910
Leu Val Phe Asp His Pro Thr Ala Gln Ala Leu Ala Ala His Leu Asp
915 920 925
<210> 24
<211> 893
<212> PRT
<213> Streptomyces kanamyceticus
<400> 24
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly
20 25 30
Ile Thr Thr Phe Pro Gly Asp Arg Gly Trp Asp Val Glu Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Glu His Pro Gly Thr Ser Thr Val Arg His Gly Gly
50 55 60
Phe Leu Ser Gly Ala Gly Asp Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Val Val Met Glu
85 90 95
Thr Ser Trp Glu Ala Leu Glu Tyr Ala Gly Ile Asp Pro His Thr Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Gly Tyr Phe Tyr Gly Tyr
115 120 125
Gly Ser Gly Ala Asp Arg Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Ser Pro Ser Gly Phe Val Asp Phe Ser
195 200 205
Gln Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu
210 215 220
Ala Ala Asp Gly Thr Gly Phe Ala Glu Gly Ser Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Gln Pro Ser Asp Val Asp Ala Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile
340 345 350
Lys Met Val Leu Ala Met His His Asp Thr Leu Pro Ser Thr Leu His
355 360 365
Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Ala Gly Thr Val Glu
370 375 380
Leu Leu Thr Asp Ala Arg Pro Trp Pro Glu Thr Ser Arg Pro His Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser His Pro Arg Pro Thr Pro Ala Pro Asp Thr Gly Ser Ser
420 425 430
Thr His Pro Val Pro Leu Leu Ile Ser Ala Arg Thr Pro Arg Ala Leu
435 440 445
Ser Glu His Thr Thr Arg Val Ser Ala Phe Leu Asp Ala Gly Gly Gly
450 455 460
Asp Glu Arg Ala Val Ala Ser Ala Leu Leu Thr Arg Thr Ala Phe Thr
465 470 475 480
His Arg Ala Ala Leu Ile Gly Thr Asp Leu Ile Thr Gly Thr Ala Val
485 490 495
Pro Asp Arg Arg Leu Val Trp Leu Phe Ser Gly Gln Gly Ser Gln Arg
500 505 510
Pro Gly Met Gly Asp Glu Leu Ala Ala Ala Tyr Asp Val Phe Ala Arg
515 520 525
Thr Arg Arg Asp Val Leu Asp Ala Leu Gln Val Pro Ala Gly Leu Asp
530 535 540
Ile His Asp Thr Gly Tyr Ala Gln Pro Ala Val Phe Ala Leu Gln Val
545 550 555 560
Ala Leu Ser Ala Gln Leu Asp Ala Trp Gly Val Arg Pro Asp Ala Leu
565 570 575
Val Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Val
580 585 590
Trp Ser Leu Asp Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu
595 600 605
Met Gln Ala Leu Pro Pro Gly Gly Ala Met Ala Ala Val Ile Ala Ser
610 615 620
Glu Arg Asp Ala Leu Pro Leu Leu Arg Glu Gly Val Glu Ile Ala Ala
625 630 635 640
Val Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val
645 650 655
Leu Asp Val Ala Ala Arg Leu Gly Arg Phe Thr Arg Leu Arg Thr Ser
660 665 670
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
675 680 685
Asp Val Ala Gln Arg Leu Thr Tyr His Glu Pro Lys Leu Pro Met Ala
690 695 700
Ala Gly Ala Asp Cys Ala Thr Pro Glu Tyr Trp Val Arg Gln Val Arg
705 710 715 720
Asp Thr Val Arg Phe Gly Glu Gln Val Ala Ala Tyr Asp Gly Ala Ala
725 730 735
Leu Leu Glu Ile Gly Pro Asp Arg Asn Leu Ala Arg Leu Val Asp Gly
740 745 750
Ile Pro Val Leu His Gly Asp Asp Glu Ala Arg Ser Ala Met Thr Ala
755 760 765
Leu Ala Arg Leu His Thr Gly Gly Val Ala Val Asp Trp Pro Glu Val
770 775 780
Ile Gly Ala Ala Pro Thr His Leu Asn Leu Pro Thr Tyr Pro Phe Glu
785 790 795 800
Arg Thr Arg Tyr Trp Leu Gly Ser Arg Asp Arg Ile Ala Gly Leu Thr
805 810 815
Ala Ala Asp Ala Glu Lys Ala Ala Leu Ala Val Val Arg Glu Cys Ala
820 825 830
Ala Ala Val Leu Gly His Glu Gly Pro Ala Arg Ile Glu Ala Thr Ala
835 840 845
Thr Phe Lys Glu Leu Gly Val Asp Ser Leu Thr Ala Val Arg Leu Arg
850 855 860
Asn Ala Phe Thr Glu Ala Thr Gly Val Arg Leu Pro Ala Thr Ala Val
865 870 875 880
Phe Asp Phe Pro Thr Pro Gln Ala Val Ala Ala Lys Leu
885 890
<210> 25
<211> 930
<212> PRT
<213> Streptomyces kanamyceticus
<400> 25
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly
20 25 30
Ile Thr Ala Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Glu His Pro Gly Thr Ser Thr Val Arg His Gly Gly
50 55 60
Phe Leu Ser Gly Ala Gly Asp Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Ile Ala Met Asp Pro Gln Gln Arg Val Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Leu Glu Gln Ala Gly Ile Val Pro Gly Thr Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Asp Gly Tyr
115 120 125
Gly Leu Gly Thr Asp Leu Gly Gly Phe Gly Ala Thr Gly Thr Gln Thr
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser
195 200 205
Gln Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Glu
210 215 220
Ala Ala Asp Gly Thr Ala Phe Ala Glu Gly Ser Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Arg Arg Gly His Arg Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Arg Pro Ser Asp Val Asp Ala Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile
340 345 350
Lys Met Val Leu Ala Met Arg His Gly Ser Leu Pro Arg Thr Leu Tyr
355 360 365
Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Ala Gly Gly Val Glu
370 375 380
Leu Leu Thr Asp Ala Arg Pro Trp Pro Ala Thr Thr Gly Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ala His Ala Ala Pro Glu Pro Pro Ala Leu Asp Ser Pro Val
420 425 430
Val Glu Pro Ser Ala Ser Leu Phe Ala Thr Glu Leu Thr Pro Leu Pro
435 440 445
Val Ser Ala Arg Thr Ser Glu Ala Val Asp Gly Gln Val Gln Arg Leu
450 455 460
Arg Glu His Leu Ala Thr His Pro Gly Asp Asp Pro Arg Ala Val Ala
465 470 475 480
Ala Ala Leu Leu Ala Thr Arg Thr Asp Phe Pro His Arg Ala Val Leu
485 490 495
Leu Gly Asp Gly Val Val Thr Gly Thr Ala Leu Thr Ala Pro Arg Thr
500 505 510
Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Leu Gly Met Gly Arg
515 520 525
Lys Leu Met Ala Glu Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys
530 535 540
Ala Asp Ala Leu Ala Glu His Thr Gly Arg Asp Leu Ile Ala Met Leu
545 550 555 560
Asp Asp Pro Ala Val Lys Ser Arg Val Asp Val Val His Pro Val Cys
565 570 575
Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Glu Ala Ala Gly Val
580 585 590
Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala
595 600 605
Cys Val Ala Gly Ala Ile Ser Leu Glu Asp Gly Ala Arg Leu Val Ala
610 615 620
Leu Arg Ser Ala Leu Leu Val Glu Leu Ala Gly Arg Gly Ala Met Gly
625 630 635 640
Ser Ile Ala Phe Ala Ala Ala Asp Val Glu Ala Ala Ala Ala Arg Ile
645 650 655
Asp Gly Val Trp Val Ala Gly Arg Asn Gly Thr Ala Thr Thr Ile Val
660 665 670
Ser Gly Arg Pro Asp Ala Val Glu Thr Leu Ile Ala Asp Tyr Glu Thr
675 680 685
Arg Gly Val Trp Val Thr Arg Leu Val Val Asp Cys Pro Thr His Thr
690 695 700
Pro Phe Val Asp Pro Leu Tyr Asp Glu Leu Gln Arg Ile Val Ala Ala
705 710 715 720
Thr Thr Ser Arg Ala Pro Glu Ile Pro Trp Phe Ser Thr Ala Asp Glu
725 730 735
Arg Trp Ile Asp Ala Pro Leu Asp Asp Glu Tyr Trp Phe Arg Asn Met
740 745 750
Arg Asn Pro Val Gly Phe Ala Ala Ala Val Ala Ala Ala Arg Glu Pro
755 760 765
Gly Asp Thr Val Phe Ile Glu Val Ser Ala His Pro Val Leu Leu Pro
770 775 780
Ala Ile Asn Gly Thr Thr Val Gly Thr Leu Arg Arg Gly Gly Gly Ala
785 790 795 800
Asp Arg Leu Leu Asp Ser Leu Ala Lys Ala His Thr Val Gly Val Ala
805 810 815
Val Asp Trp Ala Ala His Asp Ala Ala Thr Gly Thr Ala Asp Leu Pro
820 825 830
Thr Tyr Ala Phe His His Glu Arg Tyr Trp Ile Glu Pro Ala Glu Arg
835 840 845
Leu Pro Asp Leu Ser Arg Lys Glu Gln Glu Gln Val Leu Leu Asp Val
850 855 860
Val Arg Asp Thr Ala Ala Thr Leu Leu Gly His Ala Asp Ala Arg Ala
865 870 875 880
Val Thr Ala Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr
885 890 895
Ala Leu Gly Leu Arg Asp Arg Leu Ala Glu Ala Leu Gly Ile Pro Leu
900 905 910
Pro Ala Thr Leu Val Phe Asp His Pro Ala Ala Gly Thr Leu Ser Arg
915 920 925
His Leu
930
<210> 26
<211> 870
<212> PRT
<213> Streptomyces kanamyceticus
<400> 26
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Asp Asp Leu Trp Arg Leu Leu Glu Ser Gly Gly Asp Gly
20 25 30
Ile Gly Ala Phe Pro Gly Asp Arg Gly Trp Glu Thr Gly Ala Asp Gly
35 40 45
Arg Gly Gly Phe Leu Ser Gly Ala Ala Gly Phe Asp Ala Ala Phe Phe
50 55 60
Gly Val Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val
65 70 75 80
Val Leu Glu Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro
85 90 95
His Thr Leu Asn Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Phe Phe
100 105 110
Gln Gly Tyr Gly Ile Gly Ala Asp Phe Asp Gly Tyr Gly Thr Thr Ser
115 120 125
Ile His Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu
130 135 140
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Gly Gln Ser Leu Arg Thr Gly Glu Cys Ser Leu
165 170 175
Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Ala Gly Phe Ala
180 185 190
Asp Phe Ser Glu Gln Gly Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Glu Ala Ala Asp Gly Thr Ala Phe Ser Glu Gly Ser Gly Val
210 215 220
Leu Val Val Glu Arg Leu Ser Asp Ala Glu Arg His Gly His Arg Ile
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Gly Leu Gln Pro Ser Asp Val Asp Ala Val Glu
275 280 285
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Thr Ala
290 295 300
Leu Leu Ala Thr Tyr Gly Gln His Arg Thr Thr Pro Leu Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Ile Ile Lys Met Val Leu Ala Met His His Asp Thr Leu Pro Pro
340 345 350
Thr Leu His Val Asp Thr Pro Ser Ser His Val Asp Trp Thr Thr Gly
355 360 365
Gly Val Glu Leu Leu Thr Asp Ala Arg Pro Trp Pro Thr Thr Thr Gly
370 375 380
Pro Arg Arg Ala Gly Ile Ser Ser Phe Gly Val Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Pro Thr Pro Val Pro Ser Pro Gly Ala Glu
405 410 415
Pro Gly Ala Arg Pro Val Pro Leu Pro Ile Ser Ala Arg Thr Pro Glu
420 425 430
Ala Leu Asp Glu His Thr Ile Arg Ile Arg Ala Phe Leu Asp Asp Asn
435 440 445
Pro Gly Ala Asp His Val Ala Val Ala Gln Thr Leu Ala Arg Arg Thr
450 455 460
Pro Phe Glu His Arg Ala Val Leu Leu Gly Asp Thr Leu Ile Thr Ala
465 470 475 480
Asp Pro Asn Ala Gly Ser Gly Pro Val Val Phe Val Tyr Ser Gly Gln
485 490 495
Ser Thr Leu His Pro His Thr Gly Arg Gln Leu Ala Ala Thr Tyr Pro
500 505 510
Val Phe Ala Asp Ala Trp Gly Glu Val Leu Gly His Leu Asp Ala Asp
515 520 525
Gln Gly Pro Ala Thr His Phe Ala His Gln Ile Ala Leu Thr Ala Leu
530 535 540
Leu Arg Ser Trp Gly Ile Ala Pro His Ala Val Ile Gly His Ser Leu
545 550 555 560
Gly Glu Ile Ser Ala Ala Cys Ala Ala Gly Val Leu Ser Leu Gly Asp
565 570 575
Ala Ser Ala Leu Leu Ala Ala Arg Ser Arg Leu Met Asp Glu Leu Pro
580 585 590
Ala Gly Gly Ala Met Val Thr Val Leu Thr Ser Glu Glu Asn Ala Leu
595 600 605
Arg Ala Leu Arg Pro Gly Val Glu Ile Ala Ala Val Asn Gly Pro His
610 615 620
Ser Val Val Leu Ser Gly Asp Glu Gly Pro Val Leu Ala Val Ala Gln
625 630 635 640
Gln Leu Gly Ile His His Arg Leu Pro Thr Arg His Ala Gly His Ser
645 650 655
Ala Arg Met Asp Pro Leu Val Ala Pro Leu Leu Glu Ala Ala Ser Gly
660 665 670
Leu Thr Tyr His Gln Pro Arg Ile Ala Ile Pro Gly Asp Pro Thr Thr
675 680 685
Ala Ala Tyr Trp Ala Arg Gln Val Arg Asp Gln Val Arg Phe Gln Ala
690 695 700
His Ala Glu Arg Tyr Pro Gly Ala Thr Phe Leu Glu Ile Gly Pro Asn
705 710 715 720
Gln Asp Leu Ser Pro Val Val Asp Gly Ile Pro Thr Gln Thr Gly Thr
725 730 735
Pro Asp Glu Val Gln Ala Leu His Thr Ala Leu Ala Arg Leu His Thr
740 745 750
Arg Gly Gly Val Val Asp Trp Pro Thr Val Leu Gly Gly Asp Arg Ala
755 760 765
Pro Val Ala Leu Pro Thr Tyr Pro Phe Gln His Lys Asp Tyr Trp Leu
770 775 780
Arg Ala Thr Glu Leu Ala Val Leu Pro Asp Asp Glu Arg Ala Asp Ala
785 790 795 800
Leu Leu Ala Phe Val Arg Asn Ser Thr Ala Thr Val Leu Gly His Leu
805 810 815
Gly Ala Glu Asp Ile Pro Ala Thr Ala Thr Phe Lys Glu Leu Gly Ile
820 825 830
Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ala Leu Thr Thr Ala Thr
835 840 845
Gly Val Arg Leu Asn Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Arg
850 855 860
Ala Leu Ala Ala Arg Leu
865 870
<210> 27
<211> 898
<212> PRT
<213> Streptomyces avermitilis
<400> 27
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Gly Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Ile Gly Lys Thr Phe Val Arg His Gly Gly Phe
50 55 60
Leu Asp Gly Ala Thr Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Leu Leu Glu Thr
85 90 95
Ser Trp Glu Ala Phe Glu Ser Ala Gly Ile Thr Pro Asp Ser Ala Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Ser Tyr Gly Tyr Gly
115 120 125
Thr Gly Ala Asp Thr Asn Gly Phe Gly Ala Thr Gly Ser Gln Thr Ser
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Leu Glu Gly Pro Ser
145 150 155 160
Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Gln Ser Leu Arg Ser Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Ser Pro Gly Gly Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Pro Asp Gly Arg Ala Lys Ala Phe Gly Ala Gly
210 215 220
Ala Asp Gly Thr Ser Phe Ala Glu Gly Ala Gly Ala Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Glu Arg His Gly His Thr Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Lys Leu Thr Pro Ala Asp Val Asp Ala Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Ala Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ala Gly Ile Ile Lys
340 345 350
Met Val Gln Ala Ile Arg His Gly Glu Leu Pro Pro Thr Leu His Ala
355 360 365
Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Leu Thr Ser Ala Arg Pro Trp Pro Gly Thr Gly Arg Pro Arg Arg Ala
385 390 395 400
Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu
405 410 415
Glu Ala Gly Pro Val Lys Ala Gly Pro Val Glu Ala Gly Pro Val Pro
420 425 430
Ala Ala Pro Pro Ser Ala Pro Gly Glu Asp Leu Pro Leu Leu Val Ser
435 440 445
Ala Arg Ser Pro Glu Ala Leu Asp Glu Gln Ile Gly Arg Leu Arg Thr
450 455 460
Tyr Leu Asp Thr Arg Pro Gly Val Asp Arg Ala Ala Val Ala Gln Thr
465 470 475 480
Leu Ala Arg Arg Thr His Phe Ala His Arg Ala Val Leu Leu Gly Asp
485 490 495
Thr Val Ile Thr Thr Ser Pro Ser His Gln Ala Asp Glu Leu Val Phe
500 505 510
Val Tyr Ser Gly Gln Gly Thr Gln His Pro Ala Met Gly Glu Gln Leu
515 520 525
Ala Ala Ala Phe Pro Val Phe Ala Glu Thr Trp His Asp Ala Leu Arg
530 535 540
Arg Leu Asp Asp Pro Asp Pro His Asp Pro Thr Arg Ser Gln His Thr
545 550 555 560
Leu Phe Ala His Gln Ala Ala Leu Thr Ala Leu Leu Arg Ser Trp Asp
565 570 575
Ile Thr Pro His Ala Val Ile Gly His Ser Leu Gly Glu Ile Thr Ala
580 585 590
Ala Tyr Ala Ala Gly Ile Leu Ser Leu Asp Asp Ala Cys Thr Leu Ile
595 600 605
Thr Thr Arg Ala Arg Leu Met His Thr Leu Pro Pro Pro Gly Ala Met
610 615 620
Val Thr Val Leu Thr Gly Glu Glu Glu Ala Arg Gln Ala Leu Arg Pro
625 630 635 640
Gly Val Glu Ile Ala Ala Val Asn Gly Ala His Ser Val Val Leu Ser
645 650 655
Gly Asp Glu Asp Ala Val Leu Asp Val Ala Gln Arg Leu Gly Ile His
660 665 670
His Arg Leu Pro Ala Pro His Ala Gly His Ser Ala His Met Glu Pro
675 680 685
Val Ala Ala Glu Leu Leu Ala Thr Thr Arg Arg Leu Arg Tyr Asp Arg
690 695 700
Pro His Thr Ala Ile Pro Asn Asp Pro Thr Thr Ala Glu Tyr Trp Ala
705 710 715 720
Glu Gln Val Arg Asn Pro Val Leu Phe His Ala His Thr Gln Gln Tyr
725 730 735
Pro Asp Ala Val Phe Val Glu Ile Gly Pro Gly Gln Asp Leu Ser Pro
740 745 750
Leu Val Asp Gly Ile Ala Leu Gln Asn Gly Pro Ala Asn Glu Ala His
755 760 765
Ala Leu Arg Thr Ala Leu Ala Arg Leu Phe Ser Arg Gly Ala Thr Leu
770 775 780
Asp Trp Pro Leu Val Leu Gly Gly Ala Ser Arg His Asp Pro Asp Val
785 790 795 800
Pro Ser Tyr Ala Phe Gln Gln Arg Pro Tyr Trp Ile Glu Ser Ala Arg
805 810 815
Leu Ala Glu Leu Pro Asp Ala Asp Arg Asp Thr Ala Leu Ser Thr Leu
820 825 830
Val Met Asp Ala Thr Ala Ala Val Leu Gly His Ala Asp Ala Ser Glu
835 840 845
Ile Gly Pro Thr Thr Thr Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr
850 855 860
Ala Ile Glu Leu Arg Asn Arg Leu Ala Glu Ala Thr Gly Leu Arg Leu
865 870 875 880
Ser Ala Thr Met Val Phe Asp His Pro Thr Pro Arg Val Leu Ala Ala
885 890 895
Lys Leu
<210> 28
<211> 913
<212> PRT
<213> Streptomyces kanamyceticus
<400> 28
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Arg Met Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Val Arg His Gly Gly
50 55 60
Phe Leu Ser Glu Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Trp Ala Met Asp Pro Gln Gln Arg Val Ile Leu Glu
85 90 95
Thr Val Trp Glu Ala Phe Glu Asn Ala Gly Ile Val Pro Asp Thr Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser His Gly Tyr
115 120 125
Gly Ala Gly Val Asp Leu Gly Gly Phe Gly Ala Thr Ala Thr Gln Asn
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Met Glu Gly Pro
145 150 155 160
Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Met Val Ala Leu His
165 170 175
Gln Ala Ala Gln Ser Leu Arg Asp Gly Glu Cys Ser Leu Ala Leu Ala
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Leu Gly Tyr Val Glu Phe Cys
195 200 205
Arg Gln Arg Gly Leu Ala Pro Asn Gly Arg Ala Lys Ala Phe Ala Glu
210 215 220
Gly Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Arg Asn Gly His Thr Val Leu Ala Leu
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Ile Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp
275 280 285
Lys Ala Gly Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala Gln Ala Ile Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Thr Pro Leu Tyr Leu Gly Ser Val Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Thr Thr Ala Gly Leu Ala Gly Val Ile
340 345 350
Lys Met Val Met Ala Met Arg His Gly Leu Leu Pro Lys Thr Leu His
355 360 365
Val Asp Glu Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Leu Thr Glu Ala Arg Pro Trp Pro Asp Ser Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Leu Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Gly Val Ala Glu Ser Ser Val Arg Ser Gly Gly Ser Ser Gly
420 425 430
Leu Val Pro Leu Pro Val Ser Ala Arg Thr Glu Ser Ser Leu Ala Leu
435 440 445
Gln Val Glu Arg Val Gly Glu Tyr Val Arg Gly Gly Ala Asp Leu Gly
450 455 460
Ala Val Ala Asp Gly Leu Val Arg Gly Arg Ala Val Phe Asp Arg Arg
465 470 475 480
Ala Val Leu Leu Gly Glu Ser Thr Val Ala Gly Val Ala Val Glu Gly
485 490 495
Ala Arg Thr Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Val Gly
500 505 510
Met Gly Arg Glu Leu Met Gly Ala Ser Glu Val Phe Ala Ala Arg Met
515 520 525
Arg Glu Cys Ala Ala Ala Leu Glu Pro His Thr Gly Trp Asp Val Leu
530 535 540
Asp Val Leu Gly Glu Ala Val Val Ala Asp Arg Val Glu Val Leu Gln
545 550 555 560
Pro Ala Ser Trp Ala Val Ala Val Ser Leu Ala Ala Leu Trp Gln Ala
565 570 575
His Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile
580 585 590
Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg
595 600 605
Val Val Ala Leu Arg Ser Gln Thr Ile Ala Ala Arg Leu Gly His Gly
610 615 620
Ala Met Ala Ser Ile Ala Leu Pro Ala Ser Ala Val Glu Val Ala Glu
625 630 635 640
Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Glu Ser Thr Val Val Ala
645 650 655
Gly Asp Pro Gly Ala Val Glu Arg Val Leu Ala Arg Tyr Glu Ala Ala
660 665 670
Gly Val Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro
675 680 685
His Val Glu Ala Ile Glu Glu Gln Leu Ala Asp Val Leu Gly Gly Ile
690 695 700
Thr Ser Ser Ala Pro Asp Ile Ser Trp Trp Ser Thr Val Asp Ser Gly
705 710 715 720
Trp Val Thr Glu Pro Val Gly Asp Asp Tyr Trp Tyr Arg Asn Leu Arg
725 730 735
Gln Pro Val Ala Met Asp Thr Ala Ile Ser Glu Leu Asp Gly Ser Leu
740 745 750
Phe Ile Glu Cys Ser Ala His Pro Val Leu Leu Pro Ala Leu Asp Gln
755 760 765
Glu His Thr Val Ala Ser Leu Arg Thr Asp Asp Gly Asp Trp Asp Arg
770 775 780
Phe Leu Thr Ala Leu Ala Gln Ala Trp Thr Gln Gly Ala Pro Val Asp
785 790 795 800
Trp Thr Thr Leu Ile Glu Pro Ala Pro His Arg Leu Asp Leu Pro Thr
805 810 815
Tyr Pro Phe Asp His Lys Arg Tyr Trp Ile Glu Ala Ala Ala Arg Leu
820 825 830
Ala Gly His Thr Ala Ala Glu Gln Arg Arg Val Met Gln Glu Val Val
835 840 845
Leu Arg Gln Ala Ala Ala Val Leu Ala Tyr Gly Leu Gly Glu Gln Val
850 855 860
Ala Ala Asp Arg Pro Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala
865 870 875 880
Val Asp Leu Arg Asn Arg Leu Ala Ala Glu Thr Gly Leu Arg Leu Pro
885 890 895
Thr Thr Val Val Phe Ser His Pro Thr Ala Glu Ala Leu Ala Thr His
900 905 910
Leu
<210> 29
<211> 936
<212> PRT
<213> Streptomyces kanamyceticus
<400> 29
Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Met Ala Pro Gly Asp Arg Gly Trp Asp Leu Asp Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Val Gly Lys Ala Tyr Asn Leu Arg Gly Gly
50 55 60
Phe Leu Glu Gly Ala Ala Glu Phe Asp Ala Ala Phe Phe Asp Ile Ser
65 70 75 80
Pro Arg Glu Ser Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ala Trp Glu Ala Ile Glu Arg Gly Arg Ile Asn Pro Ala Ser Leu
100 105 110
His Gly Arg Glu Ile Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr
115 120 125
Gly Leu Gly Ala Glu Asp Thr Glu Gly Asn Ala Ile Thr Gly Gly Ser
130 135 140
Thr Ser Leu Leu Ser Gly Arg Leu Ala Tyr Val Leu Gly Leu Glu Gly
145 150 155 160
Pro Ser Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Cys Gln Gly Leu Arg Leu Gly Glu Cys Glu Leu Ala Leu
180 185 190
Ala Gly Gly Val Ser Val Leu Ser Ser Pro Ala Ala Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly
210 215 220
Ser Gly Ala Asp Gly Thr Thr Trp Ala Glu Gly Val Gly Val Leu Val
225 230 235 240
Leu Glu Arg Leu Ser Asp Ala Glu Arg Leu Gly His Thr Val Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Thr Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Leu Ala Gln Gln Arg Val Ile Arg Lys Ala Leu
275 280 285
Ala Ala Ala Gly Leu Thr Ala Ala Asp Val Asp Leu Val Glu Gly His
290 295 300
Gly Thr Gly Thr Arg Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asn Arg Gln Glu Pro Val Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Ala Thr Ala Ala Ala Gly Val Ala Gly Val
340 345 350
Ile Lys Thr Val Gln Ala Ile Gly Ala Gly Thr Met Pro Arg Thr Leu
355 360 365
His Ala Asp Glu Pro Ser Pro Ala Val Asp Trp Thr Ala Gly Arg Val
370 375 380
Ser Leu Leu Thr Gly Asn Arg Pro Trp Pro Asp Asp Glu Arg Ala Arg
385 390 395 400
Arg Ala Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Val
405 410 415
Ile Leu Glu Gln His Arg Pro Glu Pro Val Ala Pro Arg Pro Pro Arg
420 425 430
Glu Glu Pro Arg Pro Leu Pro Trp Val Leu Ser Ala Arg Thr Pro Ala
435 440 445
Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg Asp His Leu Ala Ala Val
450 455 460
Pro Asp Ala Asp Pro Leu Asp Ile Gly Tyr Ala Leu Ala Thr Ser Arg
465 470 475 480
Ala Arg Phe Thr His Arg Ala Ala Val Val Ala Thr Ser Ser Asp Glu
485 490 495
Phe Arg Ala Gly Leu Asp Ser Val Ala Asp Gly Val Glu Ala Pro Gly
500 505 510
Val Val Gly Gly Thr Ala Arg Glu Arg Arg Val Ala Phe Leu Phe Asp
515 520 525
Gly Gln Gly Ala Gln Arg Val Gly Met Gly Arg Glu Leu His Gly Arg
530 535 540
Phe Pro Val Phe Ala Ala Ala Trp Asp Glu Val Ser Asp Ala Phe Gly
545 550 555 560
Lys His Leu Glu His Ser Pro Thr Asp Val Phe His Gly Glu His Gly
565 570 575
Asp Leu Ala His Asp Thr Leu Tyr Ala Gln Val Gly Leu Phe Thr Leu
580 585 590
Glu Val Ala Leu Leu Arg Leu Leu Glu His Trp Gly Val Arg Pro Asp
595 600 605
Val Leu Val Gly His Ser Val Gly Glu Val Thr Ala Ala Tyr Ala Ala
610 615 620
Gly Val Leu Thr Leu Ala Asp Ala Thr Ala Leu Ile Val Ala Arg Gly
625 630 635 640
Arg Ala Leu Arg Ala Leu Pro Pro Gly Ala Met Thr Ala Val Asp Gly
645 650 655
Ser Pro Ala Glu Val Gly Ala Phe Thr Gly Leu Asp Ile Ala Ala Val
660 665 670
Asn Gly Pro Ser Ala Val Val Leu Thr Gly Ser Pro Asp Asp Val Thr
675 680 685
Ala Phe Glu Arg Glu Trp Ala Ala Ala Gly Arg Arg Ala Lys Arg Leu
690 695 700
Asp Val Gly His Ala Phe His Ser Arg His Val Asp Gly Ala Leu Asp
705 710 715 720
Asp Phe Arg Thr Val Leu Glu Ser Leu Ser Phe Gly Ala Ala Arg Leu
725 730 735
Pro Val Val Ser Thr Thr Thr Gly Arg Asp Ala Ala Gly Asp Leu Ala
740 745 750
Thr Pro Glu His Trp Leu Arg His Ala Arg Arg Pro Val Leu Phe Ala
755 760 765
Asp Ala Val Arg Glu Leu Ala Asp Leu Gly Val Asn Met Phe Val Ala
770 775 780
Val Gly Pro Ser Gly Ala Leu Ala Ser Ala Ala Ser Glu Asn Thr Gly
785 790 795 800
Gly Ser Ala Gly Thr Tyr His Ala Val Leu Arg Ala Arg Thr Gly Glu
805 810 815
Glu Asn Ala Ala Leu Thr Ala Val Ala Glu Leu His Ala His Gly Ala
820 825 830
Pro Val Asp Leu Ala Ala Val Leu Ala Gly Gly Arg Pro Val Asp Leu
835 840 845
Pro Val Tyr Pro Phe Gln His Arg Ser Tyr Trp Leu Ala Pro Asp Asp
850 855 860
Leu Thr Val Ala Glu Ile Val Arg Arg Arg Ala Ala Ala Leu Leu Gly
865 870 875 880
Ile Ala Asp Pro Gly Asp Val Asp Ala Asp Thr Thr Phe Phe Ala Leu
885 890 895
Gly Phe Asp Ser Leu Ala Val Gln Arg Leu Arg Asn Gln Leu Thr Ala
900 905 910
Ala Thr Gly Leu Asp Leu Pro Thr Ala Val Leu Phe Asp His Asp Thr
915 920 925
Pro Ser Ala Leu Thr Ala Tyr Leu
930 935
<210> 30
<211> 901
<212> PRT
<213> Streptomyces violaceusniger
<400> 30
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Gly Thr Glu Leu Glu Gly Tyr Gly Thr Thr Ser Gly
130 135 140
Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly
145 150 155 160
Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu
180 185 190
Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Val Phe Thr Glu Phe
195 200 205
Ala Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser
210 215 220
Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Ile Gly Val Leu Leu
225 230 235 240
Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala
245 250 255
Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu
275 280 285
Gly Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Gly His
290 295 300
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val
340 345 350
Ile Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu
355 360 365
His Val Asp Glu Pro Ser Ser His Val Asp Trp Thr Ala Gly Ala Val
370 375 380
Glu Leu Val Thr Ala Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val
405 410 415
Ile Leu Glu Ser Ala Pro Ser Thr Gln Ala Val Asp Asp Val Arg Pro
420 425 430
Val Glu Thr Pro Val Val Gly Ser Glu Leu Val Pro Leu Val Leu Ser
435 440 445
Ala Lys Thr Leu Pro Ala Leu Ser Gly Tyr Glu Asp Arg Leu Arg Ala
450 455 460
Tyr Leu Ala Gly Ser Pro Gly Val Asp Leu Arg Ala Val Ala Ser Thr
465 470 475 480
Leu Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly
485 490 495
Asp Asp Thr Val Thr Gly Thr Ala Val Thr Asp Pro Arg Val Val Phe
500 505 510
Ile Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu
515 520 525
Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp
530 535 540
Leu Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln
545 550 555 560
Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser
565 570 575
Trp Gly Val Gly Pro Asp Ala Val Val Gly His Ser Val Gly Glu Leu
580 585 590
Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys Thr
595 600 605
Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly
610 615 620
Val Met Val Ala Val Pro Val Pro Glu Asp Glu Ala Arg Ala Val Leu
625 630 635 640
Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val
645 650 655
Leu Ser Gly Asp Glu Ala Ala Val Leu Arg Ala Ala Ala Thr Leu Gly
660 665 670
Lys Trp Met Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met
675 680 685
Glu Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr
690 695 700
Gln Thr Pro His Leu Thr Met Ala Ala Gly Glu Gln Val Thr Thr Pro
705 710 715 720
Asp Tyr Trp Val Arg Gln Val Arg Asp Val Val Arg Phe Gly Glu Gln
725 730 735
Val Ala Ser Phe Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg
740 745 750
Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Ala His
755 760 765
Glu Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly
770 775 780
Val Thr Val Asp Trp Pro Ala Val Leu Gly Asp Val Pro Gly Arg Val
785 790 795 800
Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu
805 810 815
Gly Trp Leu Ala Ala Leu Thr Pro Ala Glu Arg Glu Lys Ala Leu Leu
820 825 830
Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Thr
835 840 845
Ser Thr Ile Pro Val Thr Gly Ala Phe Lys Asp Leu Gly Ile Asn Ser
850 855 860
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu Leu
865 870 875 880
Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu
885 890 895
Ala Ala Arg Leu Asp
900
<210> 31
<211> 890
<212> PRT
<213> Streptomyces violaceusniger
<400> 31
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Asp
35 40 45
Ser Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly Phe Leu Asp Ala Ala
50 55 60
Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu
65 70 75 80
Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu Ala
85 90 95
Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu Arg Gly Ser Asp Thr
100 105 110
Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val Leu Ser Gly
130 135 140
Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala
165 170 175
Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val
180 185 190
Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Gly Gly Leu
195 200 205
Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr
210 215 220
Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro
260 265 270
Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu Thr
275 280 285
Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Asp
305 310 315 320
Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His
325 330 335
Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met Ala
340 345 350
Leu Arg His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro Ser
355 360 365
Arg His Val Asp Trp Ser Thr Gly Ala Val Glu Leu Val Thr Glu Asn
370 375 380
Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Gly Val Ser Ser
385 390 395 400
Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro
405 410 415
Ser Ala Gln Val Val Glu Asn Thr Val Val Glu Ser Ala Pro Glu Trp
420 425 430
Val Pro Leu Val Val Ser Ala Arg Thr Gln Ser Ala Leu Ala Asp Tyr
435 440 445
Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val Asp Leu
450 455 460
Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Val Phe Glu His
465 470 475 480
Arg Ala Val Leu Val Gly Asp Asp Thr Val Thr Gly Ser Ala Val Ser
485 490 495
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala
500 505 510
Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Leu Phe Ala Gln Ile
515 520 525
His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val Asn
530 535 540
Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu
545 550 555 560
Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly
565 570 575
His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Cys Gly Val Trp Ser
580 585 590
Leu Glu Asp Ala Cys Thr Met Val Ser Ala Arg Ala Arg Leu Met Gln
595 600 605
Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser Glu Asp
610 615 620
Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala Val Asn
625 630 635 640
Gly Pro Leu Ser Val Ile Leu Ser Gly Asp Glu Ala Ala Val Leu Arg
645 650 655
Ala Ala Ala Thr Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala
660 665 670
Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Lys Phe Arg Ala Val
675 680 685
Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr Met Ala Ala Gly
690 695 700
Asp Gln Val Ala Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Asp Val
705 710 715 720
Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp Ala Val Phe Leu
725 730 735
Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly Ile Ala
740 745 750
Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile Ser Ala Leu Ala
755 760 765
His Leu Tyr Val Asn Gly Met Ala Val Asp Trp Pro Ala Val Leu Gly
770 775 780
Asp Val Arg Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His
785 790 795 800
Gln Arg Tyr Trp Leu Glu Gly Trp Leu Ala Val Leu Ala Pro Ala Glu
805 810 815
Arg Glu Lys Ala Leu Leu Lys Leu Val Arg Asp Ser Ala Ala Leu Val
820 825 830
Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Ala Ala Ala Phe Lys
835 840 845
Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu
850 855 860
Ala Lys Ala Thr Gly Leu Arg Leu Pro Asn Thr Thr Val Phe Asp Tyr
865 870 875 880
Pro Thr Pro Ala Ile Leu Ala Ala Arg Leu
885 890
<210> 32
<211> 928
<212> PRT
<213> Streptomyces violaceusniger
<400> 32
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Ser Leu Tyr
35 40 45
Asp Ala Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Glu Gly Gly
50 55 60
Phe Leu Asp Asn Ala Ser Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Ala Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser
275 280 285
Asn Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His His Thr Val Pro Arg Thr Leu His
355 360 365
Val Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Arg Glu Asn Gln Ser Trp Pro Glu Gly Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Ser Ala Glu Glu Val Gln Pro Val Glu
420 425 430
Val Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Val Ser Ala Lys
435 440 445
Thr His Ser Ala Leu Thr Glu Ala Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Thr Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu
515 520 525
Arg Glu Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala
530 535 540
Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp
545 550 555 560
Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala
565 570 575
Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro
580 585 590
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile
595 600 605
Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg
610 615 620
Ser Gln Ala Ile Ala Arg Gly Pro Ala Gly Arg Gly Ala Met Ala Ser
625 630 635 640
Ile Ala Leu Pro Ala Gln Glu Ile Glu Leu Ala Asp Gly Ala Trp Ile
645 650 655
Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu
660 665 670
Ala Val Asp Leu Val Leu Thr Ala His Glu Ala Gln Gly Thr Arg Val
675 680 685
Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu
690 695 700
Ile Arg Asp Glu Leu Leu His Ile Thr Ala Gly Ile Gly Ser Gln Val
705 710 715 720
Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly
725 730 735
Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly
740 745 750
Phe Ala Pro Ala Ile Ser Gln Leu Gln Ala Gln Gly Glu Thr Val Phe
755 760 765
Ile Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp
770 775 780
Ala Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg
785 790 795 800
Ile Leu Thr Ala Leu Ala Gln Ala Tyr Thr His Gly Val Thr Val Asp
805 810 815
Trp Pro Ala Ile Leu Gly Thr Thr Thr Thr Arg Ala Leu Asp Leu Pro
820 825 830
Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Asn Asn Arg Leu Thr
835 840 845
Gly Arg Thr Ser Val Glu Gln His Arg Val Met Leu Glu Leu Val Leu
850 855 860
Gly Glu Ala Ala Ser Val Leu Gly His Gly Ser Pro Asp Ala Ile Ala
865 870 875 880
Thr Asp Thr Ser Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile
885 890 895
Glu Leu Arg Asn Arg Leu Met Ala Glu Thr Gly Leu Gln Leu Pro Ala
900 905 910
Thr Met Val Phe Asp Tyr Pro Thr Ala Asn Ala Leu Ala Thr His Leu
915 920 925
<210> 33
<211> 962
<212> PRT
<213> Streptomyces violaceusniger
<400> 33
Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Val Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Thr Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Lys Ser Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Val Gly Val Asp Gln Gln Arg Asp Asn Gly Ile Thr Gly Ser Ser
130 135 140
Val Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu
180 185 190
Val Ser Gly Val Ser Val Met Ser Ser Pro Ala Met Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ser Ser Asp Gly Arg Cys Lys Ser Phe Ala
210 215 220
Ala Ser Ala Asp Gly Thr Ile Trp Ser Glu Gly Val Gly Val Leu Val
225 230 235 240
Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Arg Phe Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
275 280 285
Ala Gly Ala Gly Leu Thr Ala Ser Asp Val Asp Val Val Glu Ala His
290 295 300
Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu
305 310 315 320
Ala Thr Tyr Gly Gln Glu Arg Ser Thr Pro Ala Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val
340 345 350
Ile Lys Met Val Glu Ala Met Arg His Gly Ser Leu Pro Arg Thr Leu
355 360 365
His Val Asp Asp Pro Ser Pro His Val Asp Trp Thr Ser Gly Ser Val
370 375 380
Ala Leu Leu Thr Glu His Gln Pro Trp Pro Asp Asp Ala Lys Pro Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val
405 410 415
Val Leu Glu Gln Tyr Gln Ala Pro Ala Pro Ser Val Thr Pro Val Thr
420 425 430
Pro Val Thr Pro Val Thr Pro Val Thr Pro Asn Glu Pro Arg Pro Leu
435 440 445
Ala Trp Val Leu Ser Ala Gln Ser Pro Lys Ala Leu Arg Glu Gln Ala
450 455 460
Gly Arg Leu Tyr Ala Ser Leu Ala Glu Ala Pro Glu Trp Asn Ser Leu
465 470 475 480
Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Asp Phe Ala His Arg
485 490 495
Ala Val Ala Val Gly Ser Gly Arg Glu Phe Leu Arg Ala Leu Ser Lys
500 505 510
Leu Ala Asp Gly Ala Ser Trp Pro Gly Leu Thr Thr Ala Thr Ala Lys
515 520 525
Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Ala Gln Arg Leu
530 535 540
Gly Met Gly Lys Glu Leu Tyr Asp Ser Ser Pro Val Phe Ala Arg Ala
545 550 555 560
Trp Asp Thr Val Ser Ala Gly Phe Asp Lys His Leu Asp His Ser Leu
565 570 575
Thr Asp Val Tyr Phe Gly Glu Gly Gly Ser Thr Thr Ala Glu Leu Val
580 585 590
Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Ala Met Glu Val Ala
595 600 605
Leu Phe Gly Leu Leu Glu Asp Trp Gly Val Arg Pro Asp Phe Val Ala
610 615 620
Gly His Ser Ile Gly Glu Ala Thr Ala Ala Tyr Ala Ser Gly Met Leu
625 630 635 640
Ser Leu Glu His Val Thr Thr Leu Ile Val Ala Arg Gly Arg Ala Leu
645 650 655
Arg Ala Thr Pro Pro Gly Ala Met Val Ala Leu Arg Ala Gly Glu Glu
660 665 670
Glu Val Arg Ala Phe Leu Asp Gln Thr Gly Ala Ala Leu Asp Leu Ala
675 680 685
Ala Val Asn Ser Pro Glu Ala Val Val Val Ala Gly Glu Pro Asp Ala
690 695 700
Val Ala Gly Phe Glu Ala Ala Trp Ala Ala Ser Gly Arg Glu Ala Arg
705 710 715 720
Lys Leu Arg Val Arg His Ala Phe His Ser Arg His Val Glu Ala Val
725 730 735
Leu Asp Glu Phe Arg Thr Thr Leu Glu Ser Leu Lys Phe Ser Ala Pro
740 745 750
Ala Leu Pro Val Val Ser Thr Val Thr Gly Gln Leu Ile Glu Pro Asp
755 760 765
Glu Met Gly Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg Gln Pro Val
770 775 780
Arg Phe Gln Asp Ala Val Arg Glu Leu Ala Glu Ala Gly Val Gly Thr
785 790 795 800
Phe Val Glu Ile Gly Pro Ser Gly Ala Leu Ala Ser Ala Gly Met Glu
805 810 815
Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Leu Arg Pro Arg Ser
820 825 830
Pro Glu Asp Val Cys Leu Met Thr Ala Ile Ala Glu Leu Tyr Ala Gly
835 840 845
Gly Thr Ala Ile Asp Trp Ala Lys Val Leu Ser Gly Gly Arg Ala Val
850 855 860
Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr Trp Leu Ala Pro
865 870 875 880
Ala Glu Pro Ser Tyr Ala Asp Glu Pro Arg Thr Met Leu Glu Leu Val
885 890 895
His Met Glu Val Ala Ser Val Leu Gly Met Thr Asp Pro Gly Val Ile
900 905 910
Leu Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Ser Ala
915 920 925
Val Arg Leu Arg Asn Arg Leu Ser Lys Ala Thr Gly Leu Asp Leu Pro
930 935 940
Ser Thr Leu Leu Phe Glu His Pro Thr Ser Ala Glu Leu Ala Ser His
945 950 955 960
Leu Asp
<210> 34
<211> 934
<212> PRT
<213> Streptomyces violaceusniger
<400> 34
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Arg Gly Gly
50 55 60
Phe Leu Asp Ser Val Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Gly Phe Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Ala
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Gly Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser
275 280 285
Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Ser Trp Pro Val Thr Gly Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Ala Ser Glu Glu Ala Gln Pro Val Val
420 425 430
Thr Pro Val Val Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val
435 440 445
Val Ser Ala Lys Thr Glu Ser Ala Leu Ala Glu Val Glu Gly Arg Leu
450 455 460
Arg Ala Tyr Leu Ala Val Ser Pro Gly Val Asp Leu Arg Ala Val Gly
465 470 475 480
Ser Thr Leu Ala Val Ala Arg Ser Val Phe Glu His Arg Ala Val Leu
485 490 495
Leu Gly Asp Asp Thr Val Thr Gly Thr Val Thr Gly Thr Ala Val Ser
500 505 510
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
515 520 525
Gly Met Gly Ser Ala Leu Arg Gly Ala Ser Val Val Phe Ala Glu Arg
530 535 540
Met Ala Glu Cys Ala Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu
545 550 555 560
Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val
565 570 575
Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Glu
580 585 590
Ala Ala Gly Val Arg Pro Asp Ala Val Val Gly His Ser Gln Gly Glu
595 600 605
Ile Ala Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala
610 615 620
Arg Ile Val Thr Leu Arg Ser Gln Val Ile Ala Gly Leu Ala Gly Arg
625 630 635 640
Gly Ala Met Ala Ser Val Ala Leu Pro Ala His Glu Ile Glu Leu Val
645 650 655
Glu Gly Ala Trp Ile Ala Ala Cys Asn Gly Pro Ala Ser Thr Val Ile
660 665 670
Ala Gly Glu Pro Asp Ala Val Asp Arg Val Leu Ala Val His Glu Ala
675 680 685
Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr
690 695 700
Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu Asn Ile Thr Ala Gly
705 710 715 720
Ile Gly Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly
725 730 735
Thr Trp Val Glu Gly Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu
740 745 750
Arg Glu Pro Val Gly Phe Asp Ser Ala Val Gly Glu Leu Arg Ala Gln
755 760 765
Gly Asp Thr Val Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Gln
770 775 780
Ala Met Asp Asp Asp Val Val Ser Val Ala Thr Leu Arg Arg Asp Asp
785 790 795 800
Gly Gly Ala Ala Arg Met Leu Thr Ala Leu Ala Gln Ala Phe Val Glu
805 810 815
Gly Val Thr Val Asp Trp Pro Ala Val Leu Gly Asn Ala Pro Gly Arg
820 825 830
Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His Gln Arg Tyr Trp Leu
835 840 845
Lys Ser Arg Trp Leu Ala Arg Leu Ala Pro Val Glu Arg Glu Lys Ala
850 855 860
Leu Leu Lys Val Val Cys Asp Gly Ala Ala Thr Val Leu Gly His Ala
865 870 875 880
Asp Ala Ser Thr Ile Pro Ala Ala Gly Ala Phe Arg Asp Leu Gly Val
885 890 895
Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu Ala Lys Ala Thr
900 905 910
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr
915 920 925
Ala Leu Ala Ala Arg Leu
930
<210> 35
<211> 893
<212> PRT
<213> Streptomyces violaceusniger
<400> 35
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asp Leu Phe
35 40 45
Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Arg Gly Gly Phe Leu Asp
50 55 60
Ala Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu
65 70 75 80
Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp
85 90 95
Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr
100 105 110
Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly
115 120 125
Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Val Ser Val Leu
130 135 140
Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr
145 150 155 160
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly
165 170 175
Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
180 185 190
Thr Val Met Ala Thr Pro Gln Thr Phe Ala Glu Phe Ala Arg Gln Gly
195 200 205
Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp
210 215 220
Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu
225 230 235 240
Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val Arg Gly
245 250 255
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn
260 265 270
Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Asn Asn Ala Gly
275 280 285
Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr
290 295 300
Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Ala Tyr Gly
305 310 315 320
Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu
325 330 335
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
340 345 350
Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu
355 360 365
Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu Leu Val Thr
370 375 380
Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro Gly Arg Ala Gly Val
385 390 395 400
Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
405 410 415
Ala Pro Ser Ala Gln Thr Val Glu Asn Thr Val Val Glu Ser Ala Pro
420 425 430
Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala Leu Ala
435 440 445
Asp Tyr Glu Gly Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val
450 455 460
Asp Leu Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Val Phe
465 470 475 480
Glu His Arg Ala Val Leu Met Gly Asp Asp Thr Val Thr Gly Ser Ala
485 490 495
Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln
500 505 510
Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala
515 520 525
Gln Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp
530 535 540
Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val
545 550 555 560
Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Gly Pro Asp Ala Val
565 570 575
Val Gly His Ser Val Gly Glu Leu Ala Ala Ala Tyr Ala Ser Gly Val
580 585 590
Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu
595 600 605
Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser
610 615 620
Glu Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala
625 630 635 640
Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val
645 650 655
Leu Arg Ala Ala Ala Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser
660 665 670
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg
675 680 685
Ala Val Ala Glu Arg Leu Thr Tyr Gln Thr Pro His Leu Thr Met Ala
690 695 700
Ala Gly Glu Gln Val Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg
705 710 715 720
Asp Val Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp Ala Val
725 730 735
Phe Leu Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly
740 745 750
Ile Ala Met Leu His Gly Asp His Glu Ala Gln Asp Ala Ile Ser Ala
755 760 765
Met Ala His Leu Tyr Val Ser Gly Val Ala Val Asp Trp Pro Ala Val
770 775 780
Leu Gly Asp Val Arg Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe
785 790 795 800
Gln His Glu Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala
805 810 815
Pro Ala Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Ser Asp Gly Ala
820 825 830
Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Val Pro Val Ser Ala
835 840 845
Val Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
850 855 860
Asn Arg Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
865 870 875 880
Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu
885 890
<210> 36
<211> 922
<212> PRT
<213> Streptomyces violaceusniger
<400> 36
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asp Phe Asp
35 40 45
Ser Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly Phe Leu Asp Ala Ala
50 55 60
Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu
65 70 75 80
Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Val Ser Trp Glu Thr
85 90 95
Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr Asp Thr
100 105 110
Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val Leu Ser Gly
130 135 140
Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala
165 170 175
Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly Ala Thr Val
180 185 190
Met Ala Thr Pro Glu Leu Phe Thr Glu Phe Ser Arg Gln Gly Gly Leu
195 200 205
Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr
210 215 220
Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro
260 265 270
Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu Ala
275 280 285
Ala Tyr Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln Asp
305 310 315 320
Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
325 330 335
Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met Val Met Ala
340 345 350
Leu Gln Arg Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro Ser
355 360 365
Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Arg Glu Asn
370 375 380
Gln Ser Trp Pro Asp Thr Glu Gly Pro Arg Arg Ala Gly Val Ser Ser
385 390 395 400
Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro
405 410 415
Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val Thr Pro Val Val Ala
420 425 430
Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys Ser Gln Ser Ala Leu
435 440 445
Thr Glu Ala Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly
450 455 460
Val Asp Thr Arg Ala Val Gly Ala Thr Leu Ala Val Ala Arg Ser Val
465 470 475 480
Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr
485 490 495
Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln
500 505 510
Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser Ser Val
515 520 525
Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Phe
530 535 540
Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala Val Val Asp
545 550 555 560
Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu
565 570 575
Ala Ala Val Trp Glu Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly
580 585 590
His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile Ala Gly Ala Leu Ser
595 600 605
Leu Arg Asp Ala Ala Arg Ile Val Ser Leu Arg Ser Gln Val Ile Ala
610 615 620
Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Gln
625 630 635 640
Asp Val Glu Leu Ala Glu Gly Ala Trp Ile Ala Ala His Asn Gly Pro
645 650 655
Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala Val Asp Arg Val Leu
660 665 670
Ala Val His Glu Ala Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp
675 680 685
Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu
690 695 700
His Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro Val Val Pro Trp Leu
705 710 715 720
Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu Asp Ala Glu Tyr
725 730 735
Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe Ala Pro Ala Ile Arg
740 745 750
Gln Leu Gln Asp Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala Ser
755 760 765
Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Ser Val Ala Thr
770 775 780
Leu Arg Arg Asp Asp Gly Gly Ala Ala Arg Met Val Thr Ala Leu Ala
785 790 795 800
Gln Ala Tyr Val Gln Gly Val Thr Val Asp Trp Pro Ala Val Leu Gly
805 810 815
Asn Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Glu His
820 825 830
Gln Arg Tyr Trp Leu Lys Ser Trp Leu Ala Ala Leu Ala Pro Ala Glu
835 840 845
Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Ser Ala Ala Val Val
850 855 860
Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Ala Gly Ala Phe Lys
865 870 875 880
Asp Leu Gly Val Asp Ser Leu Met Ala Val Glu Leu Arg Asn Arg Leu
885 890 895
Val Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr
900 905 910
Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu
915 920
<210> 37
<211> 925
<212> PRT
<213> Streptomyces violaceusniger
<400> 37
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Asp Leu Phe
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr
115 120 125
Gly Val Gly Phe Asp Arg Glu Gly Tyr Gly Ala Thr Ser Gly Pro Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu
165 170 175
Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ile Asn
275 280 285
Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr
305 310 315 320
Tyr Gly Gln Gly Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln Arg Gly Leu Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Val Arg Glu Asn Gln Ser Trp Pro Asp Ser Glu Gly Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val Thr
420 425 430
Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys Thr
435 440 445
Glu Ser Ala Leu Thr Glu Val Glu Gly Arg Leu Arg Val Tyr Leu Ala
450 455 460
Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr
485 490 495
Val Thr Gly Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val
500 505 510
Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg
515 520 525
Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala
530 535 540
Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro
545 550 555 560
Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val
565 570 575
Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp
580 585 590
Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
595 600 605
Gly Val Leu Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser
610 615 620
Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile Ala
625 630 635 640
Leu Pro Ala Gln Asp Val Glu Leu Val Glu Gly Ala Trp Val Ala Ala
645 650 655
His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala Val
660 665 670
Asp Arg Val Leu Ala Val His Glu Ala Arg Gly Val Arg Val Arg Arg
675 680 685
Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg
690 695 700
Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro Val
705 710 715 720
Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu
725 730 735
Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe Ala
740 745 750
Pro Ala Val Ser Gln Leu Gln Val Gln Gly Glu Thr Val Phe Val Glu
755 760 765
Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val
770 775 780
Ser Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Ala Ala Arg Met Leu
785 790 795 800
Thr Ala Leu Ala Gln Ala Tyr Thr Gln Gly Val Ala Val Asp Trp Pro
805 810 815
Ala Val Leu Gly Thr Thr Thr Ala Gln Val Leu Asp Leu Pro Thr Tyr
820 825 830
Ala Phe Gln His Arg Arg Tyr Trp Val Glu Trp Leu Ala Ala Leu Ala
835 840 845
Pro Glu Glu Arg Glu Lys Ala Leu Leu Arg Val Val Cys Asp Gly Ala
850 855 860
Ala Thr Val Leu Gly His Ala Asp Val Gly Ser Ile Pro Val Thr Ala
865 870 875 880
Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
885 890 895
Asn Arg Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Ala
900 905 910
Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu
915 920 925
<210> 38
<211> 899
<212> PRT
<213> Streptomyces violaceusniger
<400> 38
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu His Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ala Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Gly Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Leu Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Ala Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ser Thr Gln Ala Val Asp Asp Val Arg Pro Val
420 425 430
Glu Ala Pro Val Val Ala Ser Glu Trp Val Pro Leu Val Val Ser Ala
435 440 445
Arg Thr Leu Pro Ala Leu Val Glu Tyr Glu Gly Arg Leu Arg Ala Tyr
450 455 460
Leu Ala Gly Ser Pro Gly Val Asp Met Arg Ala Val Gly Ser Thr Leu
465 470 475 480
Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Met Gly Asp
485 490 495
Asp Thr Val Thr Gly Ser Ala Val Ser Gly Pro Arg Val Val Phe Val
500 505 510
Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala
515 520 525
Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp Leu
530 535 540
Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro
545 550 555 560
Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp
565 570 575
Gly Val Gly Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu Ala
580 585 590
Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu
595 600 605
Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val
610 615 620
Met Val Ala Val Pro Val Ser Glu Glu Glu Ala Lys Ala Val Leu Cys
625 630 635 640
Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu
645 650 655
Ser Gly Asp Glu Thr Ala Val Leu Arg Ala Ala Ala Ala Leu Gly Lys
660 665 670
Ser Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu
675 680 685
Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr Gln
690 695 700
Thr Pro Arg Leu Pro Met Ala Ala Gly Glu Gln Val Thr Thr Pro Asp
705 710 715 720
Tyr Trp Val Arg Gln Val Arg Glu Pro Val Arg Phe Gly Glu Gln Ala
725 730 735
Ala Ser Cys Gly Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg Ser
740 745 750
Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His Glu
755 760 765
Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val
770 775 780
Thr Val Asp Trp Pro Ala Val Leu Gly Asp Val Pro Gly Arg Val Leu
785 790 795 800
Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu Gly
805 810 815
Trp Leu Ala Ala Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys
820 825 830
Val Val Cys Asp Thr Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg
835 840 845
Thr Ile Pro Met Thr Gly Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu
850 855 860
Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg
865 870 875 880
Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Val Leu Ala
885 890 895
Ala Arg Leu
<210> 39
<211> 926
<212> PRT
<213> Streptomyces violaceusniger
<400> 39
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Ser Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Cys Val Glu Gly Gly
50 55 60
Phe Leu Asp Asn Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Ala Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Gly Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Pro Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His His Thr Val Pro Arg Thr Leu His
355 360 365
Val Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Gln
370 375 380
Leu Val Arg Glu Asn Gln Ser Trp Pro Glu Gly Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Ser Ala Glu Glu Val Gln Pro Val Glu
420 425 430
Val Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Val Ser Ala Lys
435 440 445
Thr His Ser Ala Leu Thr Glu Ala Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu
515 520 525
Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala
530 535 540
Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp
545 550 555 560
Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala
565 570 575
Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro
580 585 590
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile
595 600 605
Ala Gly Ala Leu Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg
610 615 620
Ser Gln Val Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile
625 630 635 640
Ala Leu Pro Ala Gln Glu Val Glu Leu Ala Glu Gly Ala Trp Ile Ala
645 650 655
Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala
660 665 670
Val Asp Leu Val Leu Thr Ala His Glu Ala Gln Gly Thr Arg Val Arg
675 680 685
Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile
690 695 700
Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro
705 710 715 720
Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro
725 730 735
Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe
740 745 750
Ala Pro Ala Val Arg Gln Leu Gln Asp Gln Gly Glu Thr Val Phe Ile
755 760 765
Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Gly Asp Asp Ala
770 775 780
Val Thr Val Ala Thr Leu Arg Cys Asp Asp Gly Gly Ala Ala Arg Met
785 790 795 800
Leu Thr Ala Leu Ala Gln Ala Tyr Thr Gln Gly Val Ala Val Asp Trp
805 810 815
Pro Ala Val Leu Gly Thr Thr Thr Ala Arg Val Leu Asp Leu Pro Thr
820 825 830
Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Val Glu Trp Leu Ala Gly Leu
835 840 845
Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys Val Val Cys Asp Thr
850 855 860
Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Thr Ile Pro Leu Thr
865 870 875 880
Gly Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu
885 890 895
Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu
900 905 910
Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Val Arg Leu
915 920 925
<210> 40
<211> 926
<212> PRT
<213> Streptomyces violaceusniger
<400> 40
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Asp Leu Phe
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Ala Glu Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr
115 120 125
Ala Ala Gly Ala Ala Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu
165 170 175
Ala Ala Gln Ala Val Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Thr Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Asp Thr Val Pro Arg Thr Leu His Val
355 360 365
Asn Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Ser Trp Pro Val Thr Asp Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Pro Ser Val Asn Asn Ala Gln Pro Val Glu Thr
420 425 430
Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr
435 440 445
Leu Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala
450 455 460
Ala Ser Pro Glu Ala Asp Met Pro Ala Val Ala Ser Thr Leu Ala Val
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr
485 490 495
Val Thr Gly Thr Gly Ala Ala Val Ser Asp Pro Arg Val Val Phe Val
500 505 510
Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Gly Leu Arg
515 520 525
Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala
530 535 540
Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro
545 550 555 560
Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val
565 570 575
Met Val Ser Leu Ala Ala Val Trp Glu Ala Ala Gly Val Arg Pro Asp
580 585 590
Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
595 600 605
Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser
610 615 620
Gln Val Ile Ala Gly Leu Ala Gly Arg Gly Gly Met Ala Ser Val Ala
625 630 635 640
Leu Pro Ala His Glu Ile Glu Leu Val Glu Gly Ala Trp Ile Ala Ala
645 650 655
Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly Glu Pro Asp Ala Val
660 665 670
Asp Arg Val Leu Ala Ile His Glu Ala Gln Gly Val Arg Val Arg Arg
675 680 685
Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile His
690 695 700
Asp Glu Leu Leu Gly Val Ile Ala Gly Val Asp Ser Gln Ala Pro Val
705 710 715 720
Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro Leu
725 730 735
Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Gln Val Gly Phe Asp
740 745 750
Pro Ala Val Ser Gln Leu Arg Ala Glu Gly Asp Thr Val Phe Val Glu
755 760 765
Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Ala Ala
770 775 780
Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Ala Arg Met Leu
785 790 795 800
Thr Ala Leu Ala Gln Ala Phe Val Glu Gly Val Thr Val Asp Trp Pro
805 810 815
Ala Ile Leu Gly Thr Ala Thr Pro Gly Val Leu Asp Leu Pro Thr Tyr
820 825 830
Ala Phe Gln His Gln Arg Phe Trp Ala Glu Arg Trp Leu Ala Arg Leu
835 840 845
Ala Pro Val Glu Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Gly
850 855 860
Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Ala Thr
865 870 875 880
Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu
885 890 895
Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu
900 905 910
Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu
915 920 925
<210> 41
<211> 893
<212> PRT
<213> Streptomyces violaceusniger
<400> 41
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Gly Asp Leu Phe
35 40 45
Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Arg Gly Gly Phe Leu Asp
50 55 60
Ala Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu
65 70 75 80
Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp
85 90 95
Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr
100 105 110
Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly
115 120 125
Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ala Thr Ser Val Leu
130 135 140
Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr
145 150 155 160
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly
165 170 175
Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
180 185 190
Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ala Arg Gln Gly
195 200 205
Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp
210 215 220
Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu
225 230 235 240
Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Met Leu Arg Ser
245 250 255
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn
260 265 270
Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly
275 280 285
Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr
290 295 300
Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly
305 310 315 320
Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu
325 330 335
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
340 345 350
Met Ala Leu Arg Asn Gly Leu Val Pro Arg Thr Leu His Val Asp Glu
355 360 365
Pro Ser Arg His Val Asp Trp Ser Val Gly Ala Val Glu Leu Val Thr
370 375 380
Glu Asn Gln Ser Trp Pro Asp Ser Gly Arg Pro Arg Arg Ala Gly Val
385 390 395 400
Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
405 410 415
Glu Pro Pro Ala Gln Val Val Glu Asn Thr Val Val Glu Pro Ala Pro
420 425 430
Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala Leu Ala
435 440 445
Asp Tyr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro Gly Val
450 455 460
Asp Leu Arg Ala Val Gly Ser Thr Leu Ala Val Thr Arg Ser Val Phe
465 470 475 480
Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala
485 490 495
Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln
500 505 510
Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala
515 520 525
Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu
530 535 540
Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val
545 550 555 560
Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Gly Pro Asp Ala Val
565 570 575
Ile Gly His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu
580 585 590
Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu
595 600 605
Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser
610 615 620
Glu Glu Glu Ala Glu Ala Val Leu Cys Glu Gly Val Glu Ile Ala Ala
625 630 635 640
Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val
645 650 655
Leu Arg Ala Ala Ala Thr Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser
660 665 670
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg
675 680 685
Ala Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr Met Ala
690 695 700
Ala Gly Asp Gln Ile Ala Thr Ala Glu Tyr Trp Val Arg Gln Val Arg
705 710 715 720
Asp Val Val Arg Phe Gly Glu Gln Ala Ala Ser Cys Gly Asp Ala Val
725 730 735
Phe Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly
740 745 750
Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile Ser Ala
755 760 765
Leu Ala His Leu Tyr Val Ser Gly Val Ala Val Asp Trp Pro Ala Val
770 775 780
Leu Gly Asp Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe
785 790 795 800
Gln His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Thr
805 810 815
Pro Glu Glu Arg Ala Lys Ala Leu Val Lys Val Val Cys Asp Ser Ala
820 825 830
Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Thr Ala
835 840 845
Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
850 855 860
Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
865 870 875 880
Phe Asp Tyr Pro Thr Ala Gly Ala Leu Ala Ala Arg Leu
885 890
<210> 42
<211> 895
<212> PRT
<213> Streptomyces violaceusniger
<400> 42
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Phe Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Leu Glu Gly Gly
50 55 60
Phe Leu Glu Thr Ala Ala Asn Phe Asp Ala Ser Phe Phe Glu Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Glu Gly Tyr Gly Ala Thr Ser Gly Leu Asn
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro His Thr Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Thr Ile Ala Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys Ser
325 330 335
Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg Asn Gly Leu Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ser Glu Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Pro Ala Gln Val Val Asp Asn Thr Val Val Glu Ser
420 425 430
Ala Pro Glu Trp Val Pro Leu Val Met Ser Ala Arg Thr Gln Ser Ala
435 440 445
Leu Ala Asp Tyr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Gly Ser Pro
450 455 460
Gly Val Asp Leu Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser
465 470 475 480
Val Phe Glu His Arg Ala Val Leu Met Gly Asp Asp Thr Val Thr Gly
485 490 495
Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly
500 505 510
Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val
515 520 525
Phe Ala Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp
530 535 540
Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu
545 550 555 560
Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp
565 570 575
Ala Val Val Gly His Ser Ala Gly Glu Leu Ala Ala Ala Tyr Val Ser
580 585 590
Gly Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala
595 600 605
Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro
610 615 620
Val Ser Glu Glu Glu Ala Glu Ala Val Leu Cys Glu Gly Val Glu Ile
625 630 635 640
Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala
645 650 655
Ala Val Leu Arg Ala Ala Ala Gly Leu Gly Lys Trp Thr Arg Leu Ala
660 665 670
Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu
675 680 685
Phe Arg Ala Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Arg Leu Thr
690 695 700
Met Ala Ala Gly Asp Gln Val Ala Thr Ala Glu Tyr Trp Val Arg Gln
705 710 715 720
Val Arg Asp Val Val Arg Phe Gly Glu Gln Val Ala Ser Phe Glu Asp
725 730 735
Ala Val Phe Leu Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val
740 745 750
Asp Gly Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Ile
755 760 765
Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val Thr Ile Asp Trp Pro
770 775 780
Ala Val Leu Gly Gly Val Pro Gly Arg Val Leu Asp Leu Pro Thr Tyr
785 790 795 800
Ala Phe Gln His Glu Arg Tyr Trp Ala Glu Ala Trp Leu Ala Ala Leu
805 810 815
Ala Pro Ala Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Ser Asp Gly
820 825 830
Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Val Thr
835 840 845
Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu
850 855 860
Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu
865 870 875 880
Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp
885 890 895
<210> 43
<211> 927
<212> PRT
<213> Streptomyces violaceusniger
<400> 43
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Asn Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Arg Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Val Asp Phe Glu Gly Phe Gly Ala Thr Ala Gly Ala Ala
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ser Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Gly Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser
275 280 285
Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala
305 310 315 320
Thr Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Tyr Gly Leu Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Gly Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro His Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Val
420 425 430
Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Val Ser Ala Lys
435 440 445
Thr Glu Ser Ala Leu Thr Glu Val Glu Gly Arg Leu Arg Ala Tyr Leu
450 455 460
Ala Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Thr Gly Thr Ala Met Ser Asp Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu
515 520 525
Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala
530 535 540
Ala Leu Ser Asp Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp
545 550 555 560
Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala
565 570 575
Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro
580 585 590
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Ile
595 600 605
Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg
610 615 620
Ser Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Ile
625 630 635 640
Ala Leu Pro Ala Gln Glu Ile Gly Leu Ala Asp Gly Ala Trp Ile Ala
645 650 655
Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ala Pro Glu Ala
660 665 670
Val Asp Arg Val Leu Thr Ala His Glu Ala Gln Gly Ala Arg Val Arg
675 680 685
Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile
690 695 700
Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln Ala Pro
705 710 715 720
Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu Gly Pro
725 730 735
Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe
740 745 750
Ala Pro Ala Val Arg Gln Leu Gln Ala Gln Gly Glu Thr Val Phe Val
755 760 765
Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Ala
770 775 780
Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met
785 790 795 800
Leu Thr Ala Leu Ala Gln Ala Tyr Thr His Gly Val Thr Val Asp Trp
805 810 815
Pro Ala Ile Leu Gly Thr Thr Thr Thr Arg Ala Leu Asp Leu Pro Thr
820 825 830
Tyr Ala Phe Gln His Glu Arg Tyr Trp Ala Glu Ala Trp Leu Val Gly
835 840 845
Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys Leu Val Ser Asp
850 855 860
Ser Ala Ala Ala Val Leu Gly His Ala Asp Ala Arg Gly Ile Pro Ala
865 870 875 880
Thr Gly Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
885 890 895
Leu Arg Asn Thr Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr
900 905 910
Met Val Phe Asp Tyr Pro Thr Pro Ala Asp Leu Ala Ala Arg Leu
915 920 925
<210> 44
<211> 916
<212> PRT
<213> Streptomyces hygroscopicus
<400> 44
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Glu Leu Trp Gln Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Ser Pro Phe Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr
35 40 45
Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Val
65 70 75 80
Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro
85 90 95
Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser
100 105 110
Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser
115 120 125
Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe
130 135 140
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Ala Ser Ser Leu His Ile Gly Glu Cys Ser Leu
165 170 175
Ala Val Val Gly Gly Val Thr Val Val Ala Thr Pro Gly Gly Phe Val
180 185 190
Glu Phe Ala Arg Gln Gly Gly Leu Ala Leu Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Asp Ala Ala Asp Gly Ile Gly Leu Ala Glu Gly Val Gly Val
210 215 220
Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Val Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg
340 345 350
Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly
355 360 365
Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg
370 375 380
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala
405 410 415
Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val
420 425 430
Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg
435 440 445
Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala
450 455 460
Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly
465 470 475 480
Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe
485 490 495
Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu
500 505 510
Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala
515 520 525
Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp
530 535 540
Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala
545 550 555 560
Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro
565 570 575
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
580 585 590
Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg
595 600 605
Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile
610 615 620
Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala
625 630 635 640
Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala
645 650 655
Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg
660 665 670
Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu
675 680 685
His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro
690 695 700
Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro
705 710 715 720
Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu
725 730 735
Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile
740 745 750
Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr
755 760 765
Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His
770 775 780
Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile
785 790 795 800
Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp
805 810 815
Leu Pro Thr Tyr Pro Phe Gln His Lys Arg Tyr Trp Leu Gln Asp Thr
820 825 830
Glu Arg Val Ala Gly Leu Pro Ala Ala Glu Arg Glu Gln Val Val Val
835 840 845
Lys Ala Val Cys Glu Thr Ala Ala Val Val Leu Gly His Ala His Ala
850 855 860
Asp Asp Ile Leu Ala Thr Thr Leu Phe Lys Asp Leu Gly Val Asp Ser
865 870 875 880
Leu Ile Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Asp Ala Gly Leu
885 890 895
Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro His Ala Leu
900 905 910
Ala Thr Trp Leu
915
<210> 45
<211> 875
<212> PRT
<213> Streptomyces hygroscopicus
<400> 45
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Ser Asp Ile Pro Ala Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr
35 40 45
Arg Gly Gly Phe Leu Ala Asp Ala Gly Gly Phe Asp Ala Gly Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val
65 70 75 80
Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Glu Ile Glu Pro
85 90 95
Gly Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Gly Phe Ser
100 105 110
Gln Ser Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Gly
115 120 125
Ile Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Phe
130 135 140
Glu Gly Pro Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Val Gly Gly Val Thr Val Leu Ala Asp Pro Ser Gly Phe Val
180 185 190
Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Asp Thr Ala Asp Gly Thr Ser Leu Ala Glu Gly Val Gly Val
210 215 220
Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Ile Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly Thr Val Pro Arg
340 345 350
Thr Leu His Val Asp Glu Pro Ser His His Val Asp Trp Thr Ala Gly
355 360 365
Ser Val Gln Pro Ile Thr Gln Asn Gln Glu Trp Pro Gln Ala Gly Arg
370 375 380
Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro Val Val Val Ala
405 410 415
Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg Thr Pro Gly Ala
420 425 430
Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Cys Gly Ala
435 440 445
Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe Glu
450 455 460
His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala
465 470 475 480
Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala
485 490 495
Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile
500 505 510
His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val
515 520 525
Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp
565 570 575
Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val Pro Val Ser Glu
595 600 605
Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu
625 630 635 640
Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His
645 650 655
Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln
660 665 670
Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala
675 680 685
Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu
690 695 700
Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala Asp Ala Val Phe
705 710 715 720
Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu Ile Asp Gly Ile
725 730 735
Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met Thr Ala Leu Gly
740 745 750
Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala Thr Leu Leu Gly
755 760 765
Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr Pro Phe Gln His
770 775 780
Lys His Tyr Trp Ile Asp Asn Arg Arg Ile Ser Gly Leu Glu Pro Ala
785 790 795 800
Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu Ala Ala Ala Val
805 810 815
Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro Thr Thr Ala Phe
820 825 830
Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg
835 840 845
Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp
850 855 860
His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile
865 870 875
<210> 46
<211> 922
<212> PRT
<213> Streptomyces hygroscopicus
<400> 46
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala
20 25 30
Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr
35 40 45
Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala
50 55 60
Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu
65 70 75 80
Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp Glu Ala
85 90 95
Phe Glu Arg Gly Gly Ile Asn Pro Glu Ala Ile Arg Gly Ser Asn Thr
100 105 110
Gly Val Phe Ile Gly Gly Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr Ser Val Leu Ser Gly
130 135 140
Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly Pro Ala Val Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala
165 170 175
Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val
180 185 190
Met Ala Thr Pro Ala Gly Phe Glu Glu Phe Ala Arg Gln Gly Gly Leu
195 200 205
Ala Ala Asp Gly Arg Cys Lys Ala Phe Ser Asp Thr Ala Asp Gly Thr
210 215 220
Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro
260 265 270
Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr
275 280 285
Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp
305 310 315 320
Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
325 330 335
Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile Lys Thr Val Met Ala
340 345 350
Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ala Asp Glu Pro Ser
355 360 365
Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Ser Glu Asn
370 375 380
Arg Leu Trp Pro Glu Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser
385 390 395 400
Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Ile Glu Gln Pro Pro
405 410 415
His Thr Pro Ala Pro Glu Ala Glu Arg Thr Thr Gly Leu Asp Val Val
420 425 430
Pro Trp Leu Leu Ser Ala Arg Thr Pro Ala Gly Leu Arg Ala Gln Ala
435 440 445
Glu Gln Val Ser Ser Leu Asn Glu Asp Phe Ala Asn Ile Gly Phe Ser
450 455 460
Leu Ala Thr Thr Arg Thr Pro Met Glu His Arg Ala Val Val Val Ala
465 470 475 480
Asp Val Ser Gly Ile Ser Glu Ala Ala Val Phe Ala Gly Gly Gly Ser
485 490 495
Pro Thr Asp Val Val Ser Gly Leu Ala Asn Val Arg Gly Lys Thr Val
500 505 510
Phe Val Phe Pro Gly Gln Gly Ala Gln Trp Ala Gly Met Gly Ala Glu
515 520 525
Leu Phe Ala Thr Ser Pro Val Phe Ala Glu Arg Met Thr Glu Cys Ala
530 535 540
Ala Ala Phe Ala Ala Leu Val Asp Trp Ser Leu Ile Asp Val Leu Gln
545 550 555 560
Gln Arg Glu Gly Ala Pro Ser Pro Asp Arg Val Asp Val Val Gln Pro
565 570 575
Leu Ser Phe Ala Val Met Val Ser Leu Ala Ala Leu Trp Lys Ser His
580 585 590
Gly Val Val Pro Asp Ala Val Thr Gly His Ser Gln Gly Glu Val Ala
595 600 605
Ala Ala Cys Val Ser Gly Ala Leu Ser Leu Ser Asp Ala Ala Thr Val
610 615 620
Val Ala Leu Arg Ser Arg Val Ile Ala Gln Leu Ala Gly His Gly Gly
625 630 635 640
Met Val Ala Leu Pro Ala Thr Glu Phe Ala Ala Glu Tyr Trp Ala Gly
645 650 655
Arg Leu Glu Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Val Ala
660 665 670
Gly Glu Pro Glu Ala Leu Glu Glu Leu Leu Ala Glu Asn Pro Asn Ala
675 680 685
Arg Arg Ile Pro Val Asp Tyr Ala Ser His Thr Ser Arg Val Glu Arg
690 695 700
Ile Arg Glu Glu Leu Thr Gly Leu Leu Ser Gly Leu Ala Pro Arg Gln
705 710 715 720
Pro Ile Val Pro Phe Tyr Ser Thr Val Asp Asn Gln Trp Leu Asp Lys
725 730 735
Pro Leu Asp Ala Glu Tyr Trp Tyr Arg Asn Leu Arg Gln Thr Val Arg
740 745 750
Phe Ala Asp Ala Val His Gly Leu Ala Asp Ala Gly Phe Arg Ala Phe
755 760 765
Val Glu Val Ser Pro His Pro Val Leu Thr Ser Ser Met Arg Asp Ile
770 775 780
Leu Asp Glu Arg Glu Thr Thr Ala Val Val Thr Gly Thr Leu Arg Arg
785 790 795 800
Asp Ala His Gly Val Arg Glu Phe Val Arg Ser Leu Ala Arg Leu Trp
805 810 815
Val Ser Gly Phe Ser Val Asp Trp Ser Gly Leu Phe Gly Asn Gly Pro
820 825 830
Arg Arg Ile Pro Leu Pro Thr Tyr Pro Phe Gln Arg Asn Arg Tyr Trp
835 840 845
Leu Gln Ala Glu Leu Asp Leu Val Arg Thr His Ala Ala Ala Val Leu
850 855 860
Gly His Ala Gly Pro Glu Ala Val Ala Ala Asp His Pro Phe Arg Asp
865 870 875 880
Leu Gly Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Arg Leu Ala
885 890 895
Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro
900 905 910
Thr Pro Arg Ala Leu Ala Ala Trp Leu Asp
915 920
<210> 47
<211> 875
<212> PRT
<213> Streptomyces hygroscopicus
<400> 47
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Thr Ser Gly Asp Ala
20 25 30
Ile Ser Asp Ile Pro Ala Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr
35 40 45
Arg Gly Gly Phe Leu Ile Gly Ala Ala Gly Phe Asp Ala Gly Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu
65 70 75 80
Leu Leu Glu Ile Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Asn Pro
85 90 95
Glu Ser Val Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Ser Ser
100 105 110
Tyr Gly Tyr Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser
115 120 125
Thr His Ile Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe
130 135 140
Glu Gly Pro Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu
180 185 190
Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ser Asp Thr Ala Asp Gly Thr Ser Leu Ala Glu Gly Val Gly Val
210 215 220
Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Ile Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly Thr Val Pro Arg
340 345 350
Thr Leu His Val Asp Glu Pro Ser His His Val Asp Trp Thr Ala Gly
355 360 365
Ser Val Gln Pro Ile Thr Gln Asn Gln Glu Trp Pro Gln Ala Gly Arg
370 375 380
Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro Val Val Val Ala
405 410 415
Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg Thr Pro Gly Ala
420 425 430
Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Cys Gly Ala
435 440 445
Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe Glu
450 455 460
His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala
465 470 475 480
Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala
485 490 495
Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile
500 505 510
His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val
515 520 525
Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp
565 570 575
Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val Pro Val Ser Glu
595 600 605
Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu
625 630 635 640
Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His
645 650 655
Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln
660 665 670
Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala
675 680 685
Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu
690 695 700
Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala Asp Ala Val Phe
705 710 715 720
Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu Ile Asp Gly Ile
725 730 735
Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met Thr Ala Leu Gly
740 745 750
Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala Thr Leu Leu Gly
755 760 765
Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr Pro Phe Gln His
770 775 780
Lys His Tyr Trp Ile Asp Asn Thr Arg Ile Ser Gly Leu Glu Pro Ala
785 790 795 800
Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu Ala Ala Ala Val
805 810 815
Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro Thr Thr Ala Phe
820 825 830
Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn Arg
835 840 845
Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp
850 855 860
His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile
865 870 875
<210> 48
<211> 916
<212> PRT
<213> Streptomyces hygroscopicus
<400> 48
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala
20 25 30
Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr
35 40 45
Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val
65 70 75 80
Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro
85 90 95
Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser
100 105 110
Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser
115 120 125
Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe
130 135 140
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu
180 185 190
Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val
210 215 220
Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Ile Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg
340 345 350
Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly
355 360 365
Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg
370 375 380
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala
405 410 415
Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val
420 425 430
Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg
435 440 445
Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala
450 455 460
Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly
465 470 475 480
Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe
485 490 495
Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu
500 505 510
Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala
515 520 525
Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp
530 535 540
Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala
545 550 555 560
Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro
565 570 575
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
580 585 590
Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg
595 600 605
Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile
610 615 620
Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala
625 630 635 640
Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala
645 650 655
Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg
660 665 670
Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu
675 680 685
His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro
690 695 700
Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro
705 710 715 720
Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu
725 730 735
Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile
740 745 750
Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr
755 760 765
Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His
770 775 780
Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile
785 790 795 800
Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp
805 810 815
Leu Pro Thr Tyr Pro Phe Gln His Lys Arg Tyr Trp Leu Gln Asp Thr
820 825 830
Glu Arg Leu Thr Thr Gln Ser Ser Val Glu Gln His Arg Leu Met Leu
835 840 845
Asp Leu Val Thr Ser His Ala Ala Ala Val Leu Gly His Ser Ser Ala
850 855 860
Ala Ala Ile Thr Thr Asp Thr Pro Phe Arg Asp Leu Gly Phe Asp Ser
865 870 875 880
Leu Thr Ala Val Glu Leu Arg Asn Arg Val Ala Ala Asp Thr Gly Leu
885 890 895
Arg Leu Pro Ala Thr Leu Val Phe Asn His Pro Asn Ala Asp Ala Leu
900 905 910
Thr Gln Tyr Leu
915
<210> 49
<211> 950
<212> PRT
<213> Streptomyces hygroscopicus
<400> 49
Asp Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Thr Gly Thr Asp Ala
20 25 30
Ile Gly Pro Phe Pro Thr Asp Arg Gly Trp Asp Thr Glu Leu Tyr Pro
35 40 45
Val Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Glu Gly Gly Phe Leu
50 55 60
Thr Gly Ala Ala Glu Phe Asp Ala Ala Phe Phe Asp Ile Ser Pro Arg
65 70 75 80
Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser
85 90 95
Trp Glu Ala Val Glu Arg Ala Arg Ile Asn Pro Lys Ser Leu Cys Gly
100 105 110
Lys Asp Val Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Leu
115 120 125
Gly Ala Gly Asp Gln Thr Glu Gly Thr Ala Ile Thr Gly Gly Ser Thr
130 135 140
Ser Leu Ser Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Met His
165 170 175
Leu Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Ser Val Met Ala Ser Pro Ala Leu Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Ser Asp
210 215 220
Ala Ala Asp Gly Thr Asn Trp Ala Glu Gly Val Gly Val Leu Ile Leu
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Pro Val Leu Ala Val
245 250 255
Ile Arg Gly Ser Ala Ile Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Leu Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Thr
275 280 285
Ala Ala Gly Leu Arg Pro Glu Asp Val Asp Ala Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Val Glu Ala Glu Ala Ile Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asn Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Ala Ala Ala Ala Ser Gly Val Ala Gly Val Ile
340 345 350
Lys Met Val Gln Ala Met Arg Asn Gly Val Leu Pro Arg Thr Leu His
355 360 365
Ile Asp Glu Pro Ser Ser Gln Val Asp Trp Thr Ser Gly Asn Val Ala
370 375 380
Leu Leu Thr Glu Ser Arg Pro Trp Pro Asp Glu Asp Lys Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Ile Val
405 410 415
Leu Glu Gln Tyr Arg Ala Ala Glu Pro Glu Asp Arg Pro Gly Asp Gly
420 425 430
Pro Gly Glu Arg Arg Pro Val Ala Trp Val Leu Ser Gly Lys Ser Pro
435 440 445
Ala Ala Val Arg Ala Gln Ala Gly Arg Leu Arg Ala His Leu Val Gly
450 455 460
Thr Gln Gly Trp Arg Pro Val Asp Val Gly Tyr Ala Leu Ala Thr Thr
465 470 475 480
Arg Ala Asp Phe Ala His Arg Ala Val Ala Val Gly Ser Gly Pro Glu
485 490 495
Phe Leu His Ala Leu Glu Lys Leu Ala Glu Gly Ala Ser Trp Pro Arg
500 505 510
Leu Thr Thr Asn Arg Ala Ser Ala Arg Arg Val Ala Phe Leu Phe Asp
515 520 525
Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Glu Leu His Gln Arg
530 535 540
Phe Pro Ala Phe Ala Glu Ala Trp Asp Thr Val Asp Ala Glu Phe Ala
545 550 555 560
Pro Tyr Leu Asp Arg Ser Leu Thr Glu Val Phe Phe Ser Asp Gly Gly
565 570 575
Ser Gly Leu Met Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe Ala
580 585 590
Val Glu Thr Ala Leu Phe Arg Leu Leu Ala Gly Trp Gly Val Arg Pro
595 600 605
Asp Phe Val Ala Gly His Ser Ala Gly Glu Ile Thr Ala Ala His Val
610 615 620
Ala Gly Val Leu Ser Val Thr Asp Ala Val Arg Leu Ile Val Ala Arg
625 630 635 640
Gly Gln Ala Leu Arg Leu Ala Pro Pro Gly Ala Met Ala Ser Val Arg
645 650 655
Ser Ser Ala Gln Glu Val Arg Asp Phe Ile Ala Gln Ser Gly Leu Pro
660 665 670
Val Asp Leu Ala Ala Ile Asn Ser Pro Gly Ser Val Val Val Ala Gly
675 680 685
Ser Pro Glu Thr Ile Ala Glu Phe Glu Gly Ala Trp Thr Ala Ser Gly
690 695 700
Arg Gln Ala Lys Arg Leu Ala Val Arg His Ala Phe His Ser Arg His
705 710 715 720
Val Asp Gly Val Leu Asp Glu Phe Arg Ala Ala Leu Gly Gly Cys Arg
725 730 735
Phe Gly Val Ala Glu Leu Pro Leu Val Ser Thr Ala Thr Gly Glu Leu
740 745 750
Ala Ser Pro Asp Glu Leu Gly Thr Pro Glu His Trp Leu Arg His Ala
755 760 765
Arg Gln Thr Val Arg Phe Gln Asp Ala Ile Arg Ala Leu Thr Glu Gln
770 775 780
Gly Val Asp Thr Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser
785 790 795 800
Ala Gly Met Glu Cys Gly Gly Gly Thr Ala Ala Phe His Ala Val Met
805 810 815
Arg Ala Arg Gln Pro Glu Glu Val Ser Leu Met Thr Ala Val Ala Glu
820 825 830
Leu Tyr Ala Gly Gly Thr Pro Val Glu Trp Ser Arg Val Leu Asp Gly
835 840 845
Arg Ser Val Val Asp Leu Pro Val Tyr Pro Phe Gln Arg Gln Pro Tyr
850 855 860
Trp Leu Ala Pro Ala Asp Glu Leu Ser Gln Pro Glu Gln Gln Lys Ala
865 870 875 880
Leu Leu Glu Leu Val Lys Ala Glu Ala Ala Val Leu Leu Gly Ile Thr
885 890 895
Asp Ala Thr Ala Ile Glu Asp Asp Ala Arg Phe Leu Glu Leu Gly Phe
900 905 910
Asp Ser Leu Ser Ala Thr Arg Leu Arg Asn Gln Leu Ala Lys Ala Thr
915 920 925
Gly Leu Ala Leu Glu Gln Thr Leu Leu Phe Asp Phe Pro Thr Pro Ala
930 935 940
Ala Leu Ala Ala His Leu
945 950
<210> 50
<211> 879
<212> PRT
<213> Streptomyces hygroscopicus
<400> 50
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Val
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Thr Gly Glu Asp
35 40 45
Ser Ser Phe Ile Arg Gly Gly Phe Leu Thr Asp Ala Gly Gly Phe Asp
50 55 60
Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro
65 70 75 80
Gln Gln Arg Leu Val Leu Glu Thr Ser Trp Glu Val Leu Glu Arg Ala
85 90 95
Gly Ile Glu Pro Gly Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Ile
100 105 110
Gly Gly Phe Ser Gln Gly Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe
115 120 125
Gly Ala Thr Gly Thr Gln Thr Ser Val Leu Ser Gly Arg Val Ser Tyr
130 135 140
Tyr Leu Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser
145 150 155 160
Ser Ser Leu Val Ala Leu His Gln Ala Ala Ser Ala Leu Arg Gln Gly
165 170 175
Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Thr
180 185 190
His Ser Phe Val Glu Phe Ala Arg Gln Gly Gly Leu Ser Ser Asp Gly
195 200 205
Arg Cys Arg Ser Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp Ala Glu
210 215 220
Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Ser
225 230 235 240
Gly His Pro Val Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp
245 250 255
Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Leu Ser Gln Gln Arg
260 265 270
Val Ile Arg Gln Ala Leu Ala Thr Ala Gly Leu Asp Ala Ala Asp Val
275 280 285
Asp Val Val Glu Ala His Gly Thr Gly Thr Val Leu Gly Asp Pro Ile
290 295 300
Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Gly Arg Glu Glu Pro
305 310 315 320
Leu Leu Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala
325 330 335
Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Met Arg Gln Gly
340 345 350
Thr Val Pro Arg Thr Leu His Val Asp Glu Pro Ser His His Val Asp
355 360 365
Trp Thr Ala Gly Arg Val Glu Leu Leu Thr Glu Asn Arg Pro Trp Pro
370 375 380
Gln Ala Gly Arg Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser
385 390 395 400
Gly Thr Asn Ala His Val Ile Ile Glu Gly Val Pro Val Ala Glu Pro
405 410 415
Val Val Val Ala Asp Ser Gly Val Val Pro Leu Val Leu Ser Ala Arg
420 425 430
Thr Pro Gly Ala Leu Leu Glu Gln Glu Glu Arg Leu Arg Ala Tyr Leu
435 440 445
Ala Cys Gly Ala Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg
450 455 460
Ser Val Phe Glu His Arg Ser Val Leu Val Gly Asp Thr Val Val Ser
465 470 475 480
Gly Thr Ala Ala Asp Ala Arg Leu Val Leu Val Phe Ser Gly Gln Gly
485 490 495
Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Arg Phe Pro Val
500 505 510
Phe Ala Glu Ile His Gln Arg Val Trp Asp Leu Leu Asp Val Gly Pro
515 520 525
Gly Leu Asp Val Asp Asp Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala
530 535 540
Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro
545 550 555 560
Asp Val Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Cys Val
565 570 575
Ser Gly Val Trp Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg
580 585 590
Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Val Met Ala Ala Val
595 600 605
Pro Val Ser Glu Ala Glu Ala Glu Ala Val Leu Arg Glu Gly Val Glu
610 615 620
Ile Ala Ala Val Asn Gly Pro Ala Ser Ile Val Leu Ser Gly Asp Glu
625 630 635 640
Asp Ala Val Leu Gln Ala Ala Ala Ser Leu Gly Arg Phe Thr Arg Leu
645 650 655
Ser Thr Ser His Ala Phe His Cys Ala Arg Met Asp Pro Met Leu Asp
660 665 670
Glu Phe Arg Gln Val Ala Glu Ser Ile Ala Tyr Gln Pro Pro Arg Ile
675 680 685
Ala Met Ala Ala Gly Asp Gln Val Ile Thr Pro Asp Tyr Trp Val Arg
690 695 700
Gln Val Arg Glu Pro Val Arg Phe Gly Asp Gln Val Ala Ala His Ala
705 710 715 720
Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg His Leu Ala Arg Leu
725 730 735
Ile Asp Gly Ile Pro Thr Leu Ser Val Asp Glu Val Gln Ser Ala Met
740 745 750
Thr Ala Leu Gly Glu Leu His Val Arg Gly Ile Asp Val Asp Trp Ala
755 760 765
Thr Leu Leu Gly Thr Thr Pro Ala Thr Pro Thr Asp Ile Pro Thr Tyr
770 775 780
Pro Phe Gln His Lys His Tyr Trp Ile Asp Asn Thr Arg Ile Ser Gly
785 790 795 800
Leu Glu Pro Ala Glu Arg Gly Gln Ala Leu Leu Glu Ile Val Arg Glu
805 810 815
Ala Ala Ala Val Val Leu Gly His Thr Asp Ala Arg Glu Ile Ala Pro
820 825 830
Thr Thr Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala Ile Glu
835 840 845
Leu Arg Asn Arg Val Ala Thr Glu Thr Gly Leu Arg Leu Pro Ala Thr
850 855 860
Leu Val Phe Asp His Pro Thr Pro Thr Thr Leu Ala Thr Trp Ile
865 870 875
<210> 51
<211> 913
<212> PRT
<213> Streptomyces hygroscopicus
<400> 51
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala
20 25 30
Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Glu Thr Pro Tyr
35 40 45
Arg Gly Gly Phe Leu Thr Asp Pro Ala Gly Phe Asp Ala Gly Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val
65 70 75 80
Leu Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Lys Pro
85 90 95
Asp Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly Gly Phe Ser
100 105 110
Gln Gly Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ser
115 120 125
Thr Gln Thr Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe
130 135 140
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Ala Gly Phe Glu
180 185 190
Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val
210 215 220
Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Thr Val
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln
260 265 270
Ala Leu Ala Asn Ala Arg Leu Thr Pro Ala Asp Ile Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Ile Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Leu Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
325 330 335
Gly Ile Ile Lys Thr Val Met Ala Met Arg His Gly Thr Ala Pro Arg
340 345 350
Thr Leu His Ala Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly
355 360 365
Ala Val Glu Leu Leu Ser Glu Asn Arg Leu Trp Pro Glu Thr Asp Arg
370 375 380
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Ala Pro Ala Glu Ser Ala Glu Gly Pro Ala
405 410 415
Gly Met Gly Ser Glu Ser Met Gly Ser Glu Ser Gly Pro Val Val Val
420 425 430
Val Leu Ser Ala Lys Ser Ala Ser Ala Leu Ala Gly Gln Glu Glu Arg
435 440 445
Leu Arg Ala Tyr Leu Ala Ser Gly Ala Asp Val Arg Ala Val Ala Ala
450 455 460
Gly Leu Ala Arg Arg Ser Val Phe Glu His Arg Ser Val Ile Leu Gly
465 470 475 480
Asp Ser Thr Val Ser Gly Val Ala Ala Gly Val Pro Arg Val Val Phe
485 490 495
Leu Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Ala Asp Leu
500 505 510
Leu Glu Ser Ser Pro Val Phe Ala Ala Arg Met Arg Gln Cys Ala Ala
515 520 525
Glu Leu Ser Lys Tyr Thr Asp Trp Asp Leu Phe Thr Ala Leu Ser Asp
530 535 540
Pro Ala Leu Leu Asp Arg Val Asp Val Val Gln Pro Val Ser Trp Ala
545 550 555 560
Leu Met Val Ser Leu Ala Ala Leu Trp Gln His Cys Gly Val Gln Pro
565 570 575
Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
580 585 590
Ala Gly Ala Leu Thr Leu Gln Asp Gly Ala Arg Leu Ile Thr Gly Arg
595 600 605
Ser Ala Leu Ile Ala His Leu Ser Gly Arg Gly Thr Met Ala Ser Ile
610 615 620
Ala Leu Pro Ala Asp Asp Leu Thr Leu Pro Asp Asp Val Cys Ile Ala
625 630 635 640
Ala Val Asn Gly Pro Ala Thr Thr Ile Ile Ala Gly Pro Thr Pro Ala
645 650 655
Ile Glu His Leu Leu Ala Thr Tyr Glu Ala Ser Asn Ile His Thr Arg
660 665 670
Arg Ile Pro Val Asp Tyr Pro Ser His Thr Pro His Val Glu Asp Leu
675 680 685
His Asp Pro Leu Leu Ala Ile Thr Thr His Leu Thr Pro His Thr Pro
690 695 700
Thr Thr Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Ile His Thr Pro
705 710 715 720
Pro His Pro Asp Tyr Trp Tyr Arg Asn Leu Arg His Pro Val Gln Leu
725 730 735
Ala Pro Ala Ile Thr Thr Leu Thr His Pro His Pro Thr His Leu Ile
740 745 750
Glu Ile Ser Thr His Pro Val Leu Leu Pro Ala Ile Asp Thr Thr Thr
755 760 765
Thr Leu Thr Thr Thr Ala Thr Leu Arg Arg Asn His Gly Thr Pro His
770 775 780
Gln Leu Leu Thr Ser Leu Ala His Ala His Thr His Gly Ala Thr Ile
785 790 795 800
Asn Trp Pro Ala Leu Leu Gly Asn Pro Pro Thr Ala Thr Thr Ala Asp
805 810 815
Leu Pro Thr Tyr Pro Phe Gln Arg Arg Arg Phe Trp Ala Glu Arg Ile
820 825 830
Ser Gly Leu Glu Pro Ala Glu Arg Gly Gln Ala Leu Leu Glu Ile Val
835 840 845
Arg Glu Ala Ala Ala Val Val Leu Gly His Thr Asp Ala Arg Glu Ile
850 855 860
Ala Pro Thr Thr Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu Thr Ala
865 870 875 880
Ile Glu Leu Arg Asn Arg Val Ala Thr Glu Thr Gly Leu Arg Leu Pro
885 890 895
Ala Thr Leu Val Phe Asp His Pro Thr Pro Thr Thr Leu Ala Thr Trp
900 905 910
Ile
<210> 52
<211> 887
<212> PRT
<213> Streptomyces hygroscopicus
<400> 52
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr
35 40 45
Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala
50 55 60
Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu
65 70 75 80
Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Thr Ser Trp Glu Val
85 90 95
Leu Glu Arg Ala Gly Ile Glu Pro Gly Thr Leu Arg Gly Ser Glu Thr
100 105 110
Gly Val Phe Val Gly Gly Phe Thr Gln Gly Tyr Gly Thr Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Met Thr Ser Gly His Ser Ser Val Leu Ser Gly
130 135 140
Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Val Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala
165 170 175
Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val
180 185 190
Met Ala Ser Pro Gln Gly Phe Thr Glu Phe Ser Arg Gln Gly Gly Leu
195 200 205
Ser Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr
210 215 220
Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro
260 265 270
Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr
275 280 285
Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp
305 310 315 320
Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
325 330 335
Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala
340 345 350
Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ile Asp Glu Pro Ser
355 360 365
Arg His Ile Asp Trp Thr Thr Gly Ser Val Ala Leu Ser Thr Glu Asn
370 375 380
Gln Pro Trp Pro Glu Thr Gly His Pro Arg Arg Ala Gly Val Ser Ala
385 390 395 400
Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu Glu Gly Val Pro
405 410 415
Val Ala Gly Pro Pro Glu Glu Asp Val Glu Pro Gly Val Val Pro Leu
420 425 430
Leu Ile Ser Ala Lys Ser Arg Pro Ala Leu Met Glu Gln Glu Gln Arg
435 440 445
Leu Arg Thr Tyr Leu Asp Gly Ser Gln Thr Asp Ile Arg Ala Val Ala
450 455 460
Ala Thr Leu Ala His Ala Arg Ser Val Phe Glu His Arg Ser Val Leu
465 470 475 480
Val Gly Asp Thr Val Val Ser Gly Thr Ala Ala Asp Ala Arg Leu Val
485 490 495
Leu Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu
500 505 510
Leu Ala Ala Arg Phe Pro Val Phe Ala Glu Ile His Gln Arg Val Trp
515 520 525
Asp Leu Leu Asp Val Gly Pro Gly Leu Asp Val Asp Asp Thr Gly Tyr
530 535 540
Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu
545 550 555 560
Glu Ser Trp Gly Val Arg Pro Asp Val Leu Ile Gly His Ser Ile Gly
565 570 575
Glu Leu Ala Ala Ala Cys Val Ser Gly Val Trp Ser Leu Gln Asp Ala
580 585 590
Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala
595 600 605
Gly Gly Val Met Ala Ala Val Pro Val Ser Glu Ala Glu Ala Glu Ala
610 615 620
Val Leu Arg Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser
625 630 635 640
Ile Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Ala Ala Ser
645 650 655
Leu Gly Arg Phe Thr Arg Leu Ser Thr Ser His Ala Phe His Cys Ala
660 665 670
Arg Met Asp Pro Met Leu Asp Glu Phe Arg Gln Val Ala Glu Ser Ile
675 680 685
Ala Tyr Gln Pro Pro Arg Ile Ala Met Ala Ala Gly Asp Gln Val Ile
690 695 700
Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Pro Val Arg Phe Gly
705 710 715 720
Asp Gln Val Ala Ala His Ala Asp Ala Val Phe Leu Glu Ile Gly Pro
725 730 735
Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Pro Leu Leu Ser Lys
740 745 750
Glu Asp Glu Val Gln Ala Ala Leu Val Ala Leu Ala Glu Leu His Val
755 760 765
Arg Gly Val Pro Leu Glu Trp Ser Thr Val Ile Gly Gly Met Thr Ser
770 775 780
Ile Val Asp Leu Pro Thr Tyr Pro Phe Arg Arg Lys Arg Tyr Trp Ile
785 790 795 800
Glu Ser Ala Glu Arg Leu Thr Thr Gln Ser Ser Val Glu Gln His Arg
805 810 815
Leu Met Leu Asp Leu Val Thr Ser His Ala Ala Ala Val Leu Gly His
820 825 830
Ser Ser Ala Ala Ala Ile Thr Thr Asp Thr Pro Phe Arg Asp Leu Gly
835 840 845
Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Val Ala Ala Asp
850 855 860
Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asn His Pro Asn Ala
865 870 875 880
Gly Asp Leu Ala Arg His Leu
885
<210> 53
<211> 923
<212> PRT
<213> Streptomyces hygroscopicus
<400> 53
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Gln Ser Gly Gly Asp Ala
20 25 30
Ile Thr Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Thr His Leu Tyr
35 40 45
Asp Asn Asp Ala Pro Pro Val Tyr Arg Gly Gly Phe Leu Thr Asp Ala
50 55 60
Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu
65 70 75 80
Ala Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Thr Ser Trp Glu Ala
85 90 95
Phe Glu Arg Gly Gly Ile Asn Pro Glu Ala Ile Arg Gly Ser Asn Thr
100 105 110
Gly Val Phe Ile Gly Gly Phe Ser Tyr Gly Tyr Gly Thr Gly Ala Asp
115 120 125
Leu Gly Gly Phe Gly Ala Thr Ser Thr Gln Thr Ser Val Leu Ser Gly
130 135 140
Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly Pro Ala Val Thr Val Asp
145 150 155 160
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala
165 170 175
Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ala Gly Gly Val Thr Val
180 185 190
Met Ala Thr Pro Ala Gly Phe Glu Glu Phe Ala Arg Gln Gly Gly Leu
195 200 205
Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Thr Ala Asp Gly Thr
210 215 220
Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp
225 230 235 240
Ala Gln Arg Asn Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala
245 250 255
Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro
260 265 270
Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Arg Leu Thr
275 280 285
Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu
290 295 300
Gly Asp Pro Ile Glu Ala Gln Ala Ile Leu Ala Thr Tyr Gly Gln Asp
305 310 315 320
Arg Asp Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly His
325 330 335
Thr Gln Ala Ala Ala Gly Val Ala Gly Ile Ile Lys Thr Val Met Ala
340 345 350
Met Arg His Gly Thr Ala Pro Arg Thr Leu His Ala Asp Glu Pro Ser
355 360 365
Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Ser Glu Asn
370 375 380
Arg Leu Trp Pro Glu Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser
385 390 395 400
Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro
405 410 415
Ala Glu Ser Ala Glu Gly Pro Ala Gly Met Gly Ser Glu Ser Met Gly
420 425 430
Ser Glu Ser Gly Pro Val Val Val Val Leu Ser Ala Lys Ser Ala Ser
435 440 445
Ala Leu Ala Gly Gln Glu Glu Arg Leu Arg Ala Tyr Leu Ala Ser Gly
450 455 460
Ala Asp Val Arg Ala Val Ala Ala Gly Leu Ala Arg Arg Ser Val Phe
465 470 475 480
Glu His Arg Ser Val Ile Leu Gly Asp Ser Thr Val Ser Gly Val Ala
485 490 495
Ala Gly Val Pro Arg Val Val Phe Leu Phe Pro Gly Gln Gly Thr Gln
500 505 510
Trp Ala Gly Met Gly Ala Asp Leu Leu Glu Ser Ser Pro Val Phe Ala
515 520 525
Ala Arg Met Arg Gln Cys Ala Ala Glu Leu Ser Lys Tyr Thr Asp Trp
530 535 540
Asp Leu Phe Thr Ala Leu Ser Asp Pro Ala Leu Leu Asp Arg Val Asp
545 550 555 560
Val Val Gln Pro Val Ser Trp Ala Leu Met Val Ser Leu Ala Ala Leu
565 570 575
Trp Gln His Cys Gly Val Gln Pro Asp Ala Val Ile Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Gln Asp
595 600 605
Gly Ala Arg Leu Ile Thr Gly Arg Ser Ala Leu Ile Ala His Leu Ser
610 615 620
Gly Arg Gly Thr Met Ala Ser Ile Ala Leu Pro Ala Asp Asp Leu Thr
625 630 635 640
Leu Pro Asp Asp Val Cys Ile Ala Ala Val Asn Gly Pro Ala Thr Thr
645 650 655
Ile Ile Ala Gly Pro Thr Pro Ala Ile Glu His Leu Leu Ala Thr Tyr
660 665 670
Glu Ala Ser Asn Ile His Thr Arg Arg Ile Pro Val Asp Tyr Pro Ser
675 680 685
His Thr Pro His Val Glu Asp Leu His Asp Pro Leu Leu Ala Ile Thr
690 695 700
Thr His Leu Thr Pro His Thr Pro Thr Thr Pro Trp Leu Ser Thr Val
705 710 715 720
Asp Asn Thr Trp Ile His Thr Pro Pro His Pro Asp Tyr Trp Tyr Arg
725 730 735
Asn Leu Arg His Pro Val Gln Leu Ala Pro Ala Ile Thr Thr Leu Thr
740 745 750
His Pro His Pro Thr His Leu Ile Glu Ile Ser Thr His Pro Val Leu
755 760 765
Leu Pro Ala Ile Asp Thr Thr Thr Thr Leu Thr Thr Thr Ala Thr Leu
770 775 780
Arg Arg Asn His Gly Thr Pro His Gln Leu Leu Thr Ser Leu Ala His
785 790 795 800
Ala His Thr His Gly Ala Thr Ile Asn Trp Pro Ala Leu Leu Gly Asn
805 810 815
Pro Pro Thr Ala Thr Thr Ala Asp Leu Pro Thr Tyr Pro Phe Gln His
820 825 830
Lys Arg Tyr Trp Leu Gln Asp Thr Arg Leu Ser Ala Leu Ala Pro Ala
835 840 845
Glu Arg Glu Gln Ala Leu Val Lys Ala Val Cys Glu Thr Ala Ala Met
850 855 860
Val Leu Gly His Ala Asp Thr Arg Glu Ile Ala Ala Thr Thr Ala Phe
865 870 875 880
Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Leu Arg Asp Arg
885 890 895
Leu Ala Ala Glu Thr Gly Arg Lys Leu Pro Ala Thr Leu Val Phe Asp
900 905 910
Tyr Pro Ser Pro Gln Ala Leu Ala Ala Trp Leu
915 920
<210> 54
<211> 884
<212> PRT
<213> Actinoplanes sp.
<400> 54
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Glu Val Ala
35 40 45
Asp Gln Ser Tyr Cys Leu Gln Gly Gly Phe Leu Asp Asn Ala Ala Gly
50 55 60
Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met
65 70 75 80
Asp Pro Gln Gln Arg Leu Val Leu Glu Ala Ser Trp Glu Ala Phe Glu
85 90 95
Arg Ala Gly Ile Lys Pro Gly Ser Leu Arg Gly Ser Asp Thr Gly Val
100 105 110
Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Thr Gly Ala Asp Leu Gly
115 120 125
Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val Leu Ser Gly Arg Ile
130 135 140
Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Met Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr Ala Leu Arg
165 170 175
Gln Gly Glu Cys Ser Ile Ala Leu Val Gly Gly Val Thr Val Met Ala
180 185 190
Thr Pro Gln Ser Phe Ile Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala
195 200 205
Asp Gly Arg Cys Lys Thr Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp
210 215 220
Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg
225 230 235 240
Ala Lys Gly His Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn
245 250 255
Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly Pro Ser Gln
260 265 270
Gln Arg Val Ile Arg Gln Ala Leu Val Asn Ala Gly Leu Ser Pro Ala
275 280 285
Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp
290 295 300
Pro Ile Glu Ala Gln Ala Leu Leu Thr Thr Tyr Gly Gln Gly Arg Ser
305 310 315 320
Val Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln
325 330 335
Ala Ala Ala Gly Val Thr Gly Val Ile Lys Met Val Met Ala Leu Arg
340 345 350
His Gly Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg His
355 360 365
Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Thr Ser Asn Arg Glu
370 375 380
Trp Pro Val Val Asp Arg Pro Gly Arg Ala Gly Val Ser Ser Phe Gly
385 390 395 400
Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ala Val Pro Ser Asp
405 410 415
Thr Pro Ala Ser Thr Ser Thr Asp Ala Val Leu Pro Leu Val Val Ser
420 425 430
Ala Arg Thr Ala Pro Ala Ala Glu Asp Leu Thr Ala Arg Leu Arg Ala
435 440 445
Tyr Leu Ser Ala Ala Pro Glu Thr Asp Gln Arg Ala Ala Ala Ala Thr
450 455 460
Leu Ala Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Val Leu Gly
465 470 475 480
Asp Glu Leu Val Ser Gly Gln Ala Val Arg Asp Pro Arg Val Val Phe
485 490 495
Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu
500 505 510
Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Glu Arg Val Trp Ala
515 520 525
Leu Leu Asp Val Pro Asp Gly Leu Asp Val Asp Asp Thr Gly His Ala
530 535 540
Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ser Gly Leu Leu Glu
545 550 555 560
Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile Gly Glu
565 570 575
Leu Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys
580 585 590
Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly
595 600 605
Gly Val Met Val Ala Val Pro Val Pro Glu Ala Glu Ala Arg Ala Val
610 615 620
Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val
625 630 635 640
Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Val Ser Gly Phe
645 650 655
Ala Lys Trp Thr Arg Leu Lys Thr Ser His Ala Phe His Ser Ala His
660 665 670
Met Asp Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr
675 680 685
Tyr Arg Arg Pro Ser Val Glu Met Ala Ala Gly Asp Arg Val Thr Thr
690 695 700
Ala Glu Tyr Trp Val Arg Gln Val Arg Glu Ala Val Arg Phe Gly Asp
705 710 715 720
Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe Val Glu Ile Gly Pro Gly
725 730 735
Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Thr Met Leu His Gly Asp
740 745 750
Thr Glu Arg Glu Ala Ala Leu Thr Gly Leu Ser Gln Leu Phe Val Arg
755 760 765
Gly Val Asp Val Asp Trp Ala Thr Val Ile Glu Asp Thr Thr Ala Arg
770 775 780
Ile Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Glu Asn Tyr Trp Leu
785 790 795 800
His Trp Leu Ser Gly Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu
805 810 815
Thr Ala Val Arg Glu Asn Ala Ala Ala Val Leu Gly His Ala Asp Ala
820 825 830
Arg Thr Val Pro Val Asn Ser Ala Phe Arg Asp Leu Gly Phe Asp Ser
835 840 845
Leu Thr Ala Ile Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu
850 855 860
Ser Leu Pro Ala Thr Met Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu
865 870 875 880
Ala Thr Arg Leu
<210> 55
<211> 906
<212> PRT
<213> Actinoplanes sp.
<400> 55
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala
20 25 30
Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ser Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile
100 105 110
Lys Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Gln Gly Gly Tyr
115 120 125
Gly Ser Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Thr
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Ser Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Glu Pro Val Val Ala Glu Ala Gly Pro Val
420 425 430
Pro Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala
435 440 445
Pro Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Ala Tyr Asp Gly Ala
450 455 460
Ala Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala
465 470 475 480
Val Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro
485 490 495
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
500 505 510
Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala
515 520 525
Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala
530 535 540
Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala
565 570 575
Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Arg Val
595 600 605
Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala
610 615 620
Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Gly Leu Val Glu Gly
625 630 635 640
Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly
645 650 655
Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp Ala Arg Val
660 665 670
Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala
675 680 685
Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser Gln Pro
690 695 700
Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly
705 710 715 720
Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly
725 730 735
Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val Glu Val
740 745 750
Ser Gly Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val Thr Val
755 760 765
Ala Ser Phe Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val Thr Ser
770 775 780
Leu Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala Ala Val
785 790 795 800
Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe
805 810 815
Gln Arg Gln His Tyr Trp Ile Ser Leu Ala Ala Leu Pro Pro Ala Glu
820 825 830
Arg Glu Arg Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Val Val
835 840 845
Leu Gly His Ala Asp Gly Arg Thr Val Pro Ala Thr Ala Ala Phe Lys
850 855 860
Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu
865 870 875 880
Arg Lys Ala Thr Gly Leu Gln Leu Pro Ala Thr Leu Val Phe Asp Tyr
885 890 895
Pro Ser Pro Val Ala Leu Ala Ala Arg Leu
900 905
<210> 56
<211> 911
<212> PRT
<213> Actinoplanes sp.
<400> 56
Glu Pro Leu Ala Ile Val Gly Met Ser Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala
20 25 30
Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Ala Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Glu Ala Ala Gly Glu Phe Asp Thr Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Val Leu Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Gly Ala Asp Thr Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Val Ala Tyr
115 120 125
Gly Ala Gly Val Asp Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu
165 170 175
Ala Ala Ser Ala Leu Arg Asn Gly Glu Cys Ser Leu Ala Leu Ala Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Phe Asp Gly Arg Ser Lys Ser Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Val Leu Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Ile
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Glu Ala Ala Leu Gly Asn
275 280 285
Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Asp Leu Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ala Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val Glu Pro Val Val Ala Glu Ala Gly Pro Val Pro
420 425 430
Val Val Gly Asp Val Leu Pro Leu Val Val Ser Ala Lys Ser Ala Pro
435 440 445
Ala Leu Thr Val Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp
450 455 460
Glu Lys Ala Val Ala Ala Thr Leu Ala Ala Ala Arg Ala Thr Phe Gly
465 470 475 480
His Arg Ala Val Leu Leu Gly Gly Asp Thr Val Thr Gly Val Ala Val
485 490 495
Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp
500 505 510
Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu
515 520 525
Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp
530 535 540
Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val
545 550 555 560
Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp
565 570 575
Gln Ala Ser Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly
580 585 590
Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly
595 600 605
Ala Arg Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly
610 615 620
Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Ala Glu Ile Asp Leu
625 630 635 640
Val Glu Gly Ser Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val
645 650 655
Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp
660 665 670
Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln
675 680 685
Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Gly Glu Val Val
690 695 700
Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Ala Trp
705 710 715 720
Ile Glu Gly Pro Leu Gly Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu
725 730 735
Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe
740 745 750
Val Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala
755 760 765
Val Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Thr Ala Thr Arg Met
770 775 780
Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp
785 790 795 800
Ala Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr
805 810 815
Tyr Pro Phe Gln Arg Gln His Tyr Trp Ala Leu His Trp Leu Ala Arg
820 825 830
Leu Ser Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val Cys Glu
835 840 845
Ser Ala Ser Val Val Leu Gly His Ala Asp Ala Gly Ala Ile Pro Val
850 855 860
Thr Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
865 870 875 880
Leu Arg Asn Ser Leu Ala Thr Ala Thr Gly Gln Arg Leu Pro Ala Thr
885 890 895
Ala Val Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg Leu
900 905 910
<210> 57
<211> 879
<212> PRT
<213> Actinoplanes sp.
<400> 57
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Val Ser Gly Ser Asp Val
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Gly Val Glu Gly Leu Arg
35 40 45
Gly Gly Phe Leu Pro Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Val Leu Glu Arg Ala Gly Ile Ala Pro Gly
85 90 95
Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu
130 135 140
Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Asn Ser Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Gln Thr Phe Val Glu
180 185 190
Phe Glu Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe
195 200 205
Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu
225 230 235 240
Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
260 265 270
Leu Ala Asn Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu
290 295 300
Leu Ala Thr Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser
305 310 315 320
Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
355 360 365
Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Thr Asp Arg Pro
370 375 380
Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Ala Val Pro Val Val Ser Ala Val Ser Thr Gly Gly
405 410 415
Glu Val Gln Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala Glu
420 425 430
Asp Leu Thr Ala Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Asp Thr
435 440 445
Asp Gln Arg Ala Ala Ala Thr Thr Leu Ala Leu Thr Arg Ser Val Phe
450 455 460
Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala Ala
465 470 475 480
Val Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln
485 490 495
Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala
500 505 510
Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu
515 520 525
Asp Val Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln
530 535 540
Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala
545 550 555 560
Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly
565 570 575
Val Trp Ser Leu Glu Asp Ala Cys Val Leu Val Ser Ala Arg Ala Arg
580 585 590
Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val
595 600 605
Pro Glu Ala Glu Ala Arg Ala Val Leu Arg Asp Gly Val Glu Ile Ala
610 615 620
Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala
625 630 635 640
Val Leu Gln Ala Val Ala Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr
645 650 655
Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe
660 665 670
Arg Ala Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met
675 680 685
Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val
690 695 700
Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala
705 710 715 720
Val Phe Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp
725 730 735
Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu Thr
740 745 750
Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Pro Ala
755 760 765
Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr Pro
770 775 780
Phe Gln Arg Gln Arg Tyr Trp Leu Thr Pro Arg Trp Leu Ala Gly Met
785 790 795 800
Ser Pro Glu Asp Arg Arg Gln Ala Leu Leu Arg Val Val Arg Asp Ser
805 810 815
Ala Ala Val Val Leu Gly His Ala Glu Ala Gly Thr Ile Pro Pro Asn
820 825 830
Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu
835 840 845
Arg Asn Ser Leu Ala Thr Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu
850 855 860
Val Phe Asp Tyr Pro Ala Pro Glu Thr Leu Ala Ala Arg Leu Asp
865 870 875
<210> 58
<211> 892
<212> PRT
<213> Actinoplanes sp.
<400> 58
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Val Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Arg Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr
115 120 125
Gly Leu Gly Ala Asp Leu Glu Gly Tyr Gly Val Thr Gly Gly Pro Asn
130 135 140
Ala Val Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Gly Thr Pro Gln Thr Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ser Phe Ser Asp Gln
210 215 220
Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Val Lys Ser
325 330 335
Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Ile Val Pro Gln Thr Leu His Val
355 360 365
Ser Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Gly Arg Pro Gly Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Gly Val Pro Ser Asn Thr Pro Val Ser Thr Ala Ala Gly Asp Val
420 425 430
Leu Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Val Glu Asp Leu
435 440 445
Thr Ala Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Gly Thr Asp Gln
450 455 460
Arg Ala Ala Ala Thr Thr Leu Ala Leu Thr Arg Ser Val Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Glu Asp Thr Ile Thr Gly Val Ala Val Pro
485 490 495
Asp Ser Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala
500 505 510
Gly Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Ala Ile
515 520 525
His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu Asp Val
530 535 540
Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
545 550 555 560
Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile
565 570 575
Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly Val Trp
580 585 590
Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
595 600 605
Gln Ala Leu Pro Ser Gly Gly Val Met Val Ala Val Pro Val Pro Glu
610 615 620
Ala Glu Ala Arg Ala Val Leu Arg Asp Gly Val Glu Ile Ala Ala Val
625 630 635 640
Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu
645 650 655
Gln Ala Val Ala Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr Ser His
660 665 670
Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe Arg Ala
675 680 685
Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met Ala Ala
690 695 700
Gly Asp Arg Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Glu
705 710 715 720
Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe
725 730 735
Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile
740 745 750
Thr Met Leu His Gly Glu Asn Glu Gly His Ala Ala Leu Ala Ala Leu
755 760 765
Ser His Leu Phe Val Gln Gly Val Arg Val Asp Trp Pro Ala Val Leu
770 775 780
Gly Thr Thr Ala Glu Arg Val Asp Leu Pro Thr Tyr Pro Phe Gln His
785 790 795 800
Glu His Tyr Trp Ala Arg Ala Glu His Trp Leu Ala Gly Leu Pro Ala
805 810 815
Asp Glu Arg Glu Lys Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala
820 825 830
Ala Val Leu Gly His Ala Asp Gly Arg Thr Val Ala Ser Gly Ala Val
835 840 845
Phe Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn
850 855 860
Ser Leu Gly Lys Ala Thr Gly Leu Arg Leu Pro Ser Thr Ala Ala Phe
865 870 875 880
Asp Tyr Pro Thr Pro Ala Ala Leu Ala Thr Arg Leu
885 890
<210> 59
<211> 908
<212> PRT
<213> Actinoplanes sp.
<400> 59
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ser Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Val Gly Ala Phe Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Ile Glu Gly Tyr Gly Ala Thr Ala Gly Pro Ser
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Ser Pro Val Thr Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp Gly
210 215 220
Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala Ser
275 280 285
Ala Gly Leu Val Thr Ser Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Ala
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Leu Thr Ser Asn Arg Ser Trp Pro Ser Ser Glu Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val Glu Pro Val Val Ala Val Ala Gly Pro Val Pro
420 425 430
Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala Pro
435 440 445
Ala Leu Thr Ala Leu Glu Gln Arg Leu Arg Val Tyr Asp Gly Ala Ala
450 455 460
Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala Val
465 470 475 480
Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro Arg
485 490 495
Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly
500 505 510
Arg Glu Leu Arg Asp Ser Ser Val Val Phe Ala Ser Arg Met Ala Glu
515 520 525
Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Thr Ala
530 535 540
Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Val
545 550 555 560
Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ser Gly
565 570 575
Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala
580 585 590
Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Arg Val Val
595 600 605
Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala Met
610 615 620
Ala Ser Ile Ala Leu Pro Ala Ala Glu Ile Asp Leu Val Glu Gly Ser
625 630 635 640
Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly Thr
645 650 655
Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp Ala Arg Val Arg
660 665 670
Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala Ile
675 680 685
Arg Asp Glu Leu Leu Glu Leu Thr Ala Glu Val Glu Ser Arg Arg Pro
690 695 700
Asp Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly Pro
705 710 715 720
Leu Ser Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly Phe
725 730 735
Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val Glu Val Ser
740 745 750
Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val Thr Val Ala
755 760 765
Thr Leu Arg Arg Asp Asp Gly Ser Ala Leu Arg Met Val Thr Ser Leu
770 775 780
Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala Ala Val Leu
785 790 795 800
Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln
805 810 815
Arg Gln His Tyr Trp Val Thr Ala Gln Ser Leu Ala Gly Leu Pro Ala
820 825 830
Glu Asp Arg Glu Lys Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala
835 840 845
Gln Val Leu Gly His Pro Asp Gly Arg Ala Val Pro Ala Gly Ala Ala
850 855 860
Phe Ile Glu Leu Gly Val Asp Ser Leu Thr Gly Val Glu Met Arg Asn
865 870 875 880
Arg Leu Gly Gly Ile Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe
885 890 895
Asp Tyr Pro Thr Pro Ala Ala Leu Ala Gly Arg Leu
900 905
<210> 60
<211> 910
<212> PRT
<213> Actinoplanes sp.
<400> 60
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala
20 25 30
Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Lys Gly Ser Asp Thr Gly Val Tyr Met Gly Ala Phe Ser Gly Gly Tyr
115 120 125
Ala Ala Asp Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Thr Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Gln Ile Leu Ala Val Val Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Ser Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val Asp
355 360 365
Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Ala Glu Pro Val Val Ala Glu Val Gly Leu Val Pro Val
420 425 430
Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala Pro Ala
435 440 445
Leu Thr Val Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp Glu
450 455 460
Arg Thr Val Ala Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe Asp His
465 470 475 480
Arg Ala Val Leu Ile Gly Thr Glu Thr Val Thr Gly Pro Leu Met Thr
485 490 495
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
500 505 510
Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg
515 520 525
Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Phe Val Asp Trp Asp Leu
530 535 540
Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val
545 550 555 560
Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln
565 570 575
Ala Ala Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu
580 585 590
Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala
595 600 605
Leu Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg
610 615 620
Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Gly Leu Val
625 630 635 640
Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile
645 650 655
Ala Gly Ser Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp Ala
660 665 670
Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val
675 680 685
Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser
690 695 700
Gln Pro Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val
705 710 715 720
Glu Gly Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln
725 730 735
Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe Val
740 745 750
Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp Ala Val
755 760 765
Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val
770 775 780
Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Asn Val Asn Trp Ala
785 790 795 800
Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr Tyr
805 810 815
Pro Phe Gln Arg Gln Arg Tyr Trp Ala Gly His Trp Leu Ala Arg Leu
820 825 830
Ala Pro Gly Glu Arg Glu Thr Ala Leu Leu Lys Leu Val Ser Glu Ser
835 840 845
Ala Ala Ala Val Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Thr
850 855 860
Ala Val Phe Arg Asp Leu Gly Met Asp Ser Leu Thr Ala Val Glu Val
865 870 875 880
Arg Asn Ser Leu Ala Lys Thr Thr Gly Leu Arg Leu Pro Ala Thr Leu
885 890 895
Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg Leu
900 905 910
<210> 61
<211> 878
<212> PRT
<213> Actinoplanes sp.
<400> 61
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Val Ser Gly Ser Asp Val
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Gly Val Glu Gly Leu Arg
35 40 45
Gly Gly Phe Leu Pro Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Val Leu Glu Arg Ala Gly Ile Ala Pro Gly
85 90 95
Ser Leu Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu
130 135 140
Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Asn Ser Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Gln Thr Phe Val Glu
180 185 190
Phe Glu Arg Gln Gly Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe
195 200 205
Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Ile Leu
225 230 235 240
Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
260 265 270
Leu Ala Asn Ala Ser Leu Thr Val Ala Asp Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu
290 295 300
Leu Ala Thr Tyr Gly Gln Gly Arg Ser Val Pro Leu Leu Leu Gly Ser
305 310 315 320
Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
355 360 365
Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Val Asp Arg Pro
370 375 380
Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Ile Pro Ser Asn Thr Pro Val Ser Thr Ala Ala
405 410 415
Gly Ala Val Leu Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala
420 425 430
Glu Asp Leu Thr Ala Arg Leu Arg Ala Tyr Leu Ser Ala Ala Pro Glu
435 440 445
Thr Asp Gln Arg Ala Ala Ala Ala Thr Leu Ala Leu Thr Arg Ser Val
450 455 460
Phe Glu His Arg Thr Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala
465 470 475 480
Ala Met Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser
485 490 495
Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe
500 505 510
Ala Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly
515 520 525
Leu Asp Ile Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu
530 535 540
Gln Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp
545 550 555 560
Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser
565 570 575
Gly Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala
580 585 590
Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro
595 600 605
Val Ser Glu Ala Glu Ala Arg Thr Val Leu Arg Asp Gly Val Glu Ile
610 615 620
Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp
625 630 635 640
Ala Val Leu Gln Ala Val Ser Gly Phe Ala Lys Trp Thr Arg Leu Lys
645 650 655
Thr Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu
660 665 670
Phe Arg Ala Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu
675 680 685
Met Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln
690 695 700
Val Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp
705 710 715 720
Ala Val Phe Val Glu Ile Gly Pro Gly Arg Asn Leu Ala Arg Leu Ile
725 730 735
Asp Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu
740 745 750
Thr Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Ala
755 760 765
Thr Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr
770 775 780
Pro Phe Gln His Glu Arg Tyr Trp Leu Ser Trp Leu Val Gly Leu Pro
785 790 795 800
Pro Ala Glu Arg Ala Lys Ala Leu Leu Lys Thr Val Arg Asp Ser Ala
805 810 815
Ala Val Val Leu Gly His Gln Gly Thr Arg Ala Ile Pro Val Asp Gly
820 825 830
Ala Phe Arg Glu Leu Gly Met Asp Ser Leu Thr Ala Val Glu Leu Arg
835 840 845
Asn Ser Leu Ala Lys Ala Thr Gly Leu Ser Leu Ser Ala Thr Leu Val
850 855 860
Phe Asp Tyr Pro Thr Pro Lys Val Leu Ala Asp His Leu Asp
865 870 875
<210> 62
<211> 907
<212> PRT
<213> Actinoplanes sp.
<400> 62
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Glu Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala
20 25 30
Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Ala Asp Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Ile
100 105 110
Lys Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ser Gly Val Glu Leu Gly Gly Phe Gly Ala Thr Ser Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Asp Cys Ser Met Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ser Thr Pro His Ile Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp
210 215 220
Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile His Ala Ala Leu Ala
275 280 285
Ser Ala Gly Leu Val Thr Ser Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Val Glu Pro Val Val Ala Glu Ala Gly Pro Val
420 425 430
Pro Val Val Ser Asp Val Leu Pro Leu Val Leu Ser Ala Lys Ser Ala
435 440 445
Pro Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Val Tyr Asp Gly Ala
450 455 460
Ala Gly Arg Ala Leu Ala Thr Ala Arg Ala Thr Phe Asp His Arg Ala
465 470 475 480
Val Leu Ile Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp Pro
485 490 495
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
500 505 510
Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala
515 520 525
Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala
530 535 540
Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala
565 570 575
Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly Ala Leu Val
595 600 605
Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly Arg Gly Ala
610 615 620
Met Ala Ser Ile Ala Leu Pro Ala Thr Glu Ile Ser Leu Val Glu Gly
625 630 635 640
Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Ile Ala Gly
645 650 655
Ser Pro Glu Ala Val Glu Gln Val Leu Ala Val Gln Asp Ala Arg Val
660 665 670
Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln Val Glu Ala
675 680 685
Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Gly Val Ser Ser Gln Leu
690 695 700
Pro Thr Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp Val Glu Gly
705 710 715 720
Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu Gln Val Gly
725 730 735
Phe Ala Ala Ala Val Gln Glu Leu Gly Glu Ser Val Phe Val Glu Val
740 745 750
Ser Gly Ser Pro Val Leu Ile Gln Ser Met Gly Asp Ala Val Thr Val
755 760 765
Ala Thr Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met Val Thr Ser
770 775 780
Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp Ala Ala Val
785 790 795 800
Leu Gly Ala Gly Ser Glu Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe
805 810 815
Gln Arg Asp His Phe Trp Val Leu Ser Leu Ala Ala Leu Pro Ser Ala
820 825 830
Glu Arg Glu Lys Ala Leu Val Lys Ile Val Cys Glu Ser Ala Ala Ala
835 840 845
Val Leu Gly His Thr Asp Thr Ser Ala Val Pro Ala Ala Ala Ala Phe
850 855 860
Lys Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Asp Leu Arg Asn Arg
865 870 875 880
Leu Arg Arg Ala Thr Gly Leu Gln Leu Pro Ala Thr Leu Val Phe Asp
885 890 895
Tyr Pro Thr Pro Thr Ala Met Ala Ala Arg Leu
900 905
<210> 63
<211> 911
<212> PRT
<213> Actinoplanes sp.
<400> 63
Glu Pro Leu Ala Ile Val Gly Met Ser Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Glu Ala Ala Gly Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Thr Met Asp Pro Gln Gln Arg Val Leu Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Thr Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr
115 120 125
Gly Ala Gly Ala Asp His Glu Gly Tyr Thr Ala Thr Ala Gly Val Gly
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Leu Ala Ala Ser Ala Leu Arg Asn Gly Glu Cys Ser Leu Ala Leu Ala
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Val Leu
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val
245 250 255
Ile Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Asn Ser Ser Asp Val Asp Val Leu Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ala Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg Asn Gly Leu Val Pro Arg Ser Leu His
355 360 365
Leu Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Leu Thr Ser Asn Gln Pro Trp Pro Ser Ser Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Val His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Glu Pro Val Gly Ala Glu Ala Gly Pro Leu
420 425 430
Pro Val Val Gly Asp Val Leu Pro Leu Val Val Ser Ala Lys Ser Ala
435 440 445
Pro Ala Leu Thr Ala Leu Glu Gln Arg Leu Arg Ala His Val Ala Ala
450 455 460
Asp Glu Arg Ala Ala Ala Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe
465 470 475 480
Asp His Arg Ala Val Leu Ile Gly Ala Glu Thr Val Thr Gly Val Ala
485 490 495
Ala Val Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln
500 505 510
Trp Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala
515 520 525
Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp
530 535 540
Asp Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp
545 550 555 560
Val Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val
565 570 575
Trp Gln Ala Val Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp
595 600 605
Gly Ala Leu Val Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala
610 615 620
Gly Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Ser
625 630 635 640
Leu Val Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr
645 650 655
Val Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln
660 665 670
Asp Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro
675 680 685
Gln Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Gly Glu Val
690 695 700
Val Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Ala
705 710 715 720
Trp Ile Glu Gly Pro Leu Gly Ala Asp Tyr Trp Phe Arg Asn Leu Arg
725 730 735
Glu Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val
740 745 750
Phe Val Glu Val Ser Ala Ser Pro Val Leu Met Gln Ser Met Gly Asp
755 760 765
Ala Val Cys Val Pro Ser Leu Arg Arg Asp Asp Gly Thr Ala Thr Arg
770 775 780
Met Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn
785 790 795 800
Trp Ala Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro
805 810 815
Thr Tyr Pro Phe Gln Arg Glu Arg Phe Trp Val Leu Trp Leu Ala Gly
820 825 830
Leu Ala Pro Gln Glu Arg Glu Thr Ala Leu Leu Lys Leu Val Cys Asp
835 840 845
Ser Ala Ala Val Val Leu Gly His Gly Asp Gly Gln Ala Ile Pro Asp
850 855 860
Thr Thr Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
865 870 875 880
Val Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr
885 890 895
Met Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu
900 905 910
<210> 64
<211> 877
<212> PRT
<213> Actinoplanes sp.
<400> 64
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Thr Thr Glu Pro Gly Gln
35 40 45
Gly Gly Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu
65 70 75 80
Leu Glu Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Leu
85 90 95
Ser Leu Arg Gly Ser Asp Thr Gly Val Tyr Ile Gly Ala Tyr Pro Asp
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly
115 120 125
Ser Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly Tyr Ala Leu Arg Asn Asn Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Ser Ala
180 185 190
Phe Ala Leu Gln Asp Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe
195 200 205
Ser Asp Gly Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His Gln Ile Leu
225 230 235 240
Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
260 265 270
Leu Ala Asn Ala Ser Leu Thr Pro Ala Asp Val Asp Val Ile Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu
290 295 300
Leu Ala Thr Tyr Gly Gln Gly Arg Ser Val Pro Leu Leu Leu Gly Ser
305 310 315 320
Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Thr Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
355 360 365
Val Glu Leu Val Thr Ser Asn Arg Glu Trp Pro Val Thr Asp Arg Pro
370 375 380
Gly Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Ala Val Pro Val Val Ser Ala Val Ser Thr Gly Gly
405 410 415
Glu Val Gln Pro Leu Val Val Ser Ala Arg Thr Ala Pro Ala Ala Glu
420 425 430
Asp Leu Ala Ser Arg Leu Arg Thr Tyr Leu Ala Asp Thr Pro Asp Thr
435 440 445
Asp Gln Arg Ala Ala Ala Ala Thr Leu Ala Leu Thr Arg Ser Val Phe
450 455 460
Glu His Arg Thr Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Ala Ala
465 470 475 480
Met Pro Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln
485 490 495
Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala
500 505 510
Glu Ile His Glu Arg Val Trp Ala Leu Leu Asp Val Pro Asp Gly Leu
515 520 525
Asp Ile Asp Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln
530 535 540
Val Ala Leu Ser Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala
545 550 555 560
Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly
565 570 575
Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg
580 585 590
Leu Met Gln Ala Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val
595 600 605
Pro Glu Ala Glu Ala Arg Thr Val Leu Arg Asp Gly Val Glu Ile Ala
610 615 620
Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Asp Ala
625 630 635 640
Val Leu Gln Ala Val Ser Gly Phe Ala Lys Trp Thr Arg Leu Lys Thr
645 650 655
Ser His Ala Phe His Ser Ala His Met Asp Pro Met Leu Asp Glu Phe
660 665 670
Arg Thr Val Ala Glu Arg Leu Thr Tyr Arg Arg Pro Ser Val Glu Met
675 680 685
Ala Ala Gly His Gly Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val
690 695 700
Arg Glu Ala Val Arg Phe Gly Asp Gln Thr Thr Ala Tyr Glu Asp Ala
705 710 715 720
Val Phe Val Glu Ile Gly Pro Gly Arg Thr Leu Ala Arg Leu Ile Asp
725 730 735
Gly Ile Thr Met Leu His Gly Asp Thr Glu Arg Glu Ala Ala Leu Thr
740 745 750
Gly Leu Ser Gln Leu Phe Val Arg Gly Val Asp Val Asp Trp Ala Thr
755 760 765
Val Ile Glu Asp Thr Thr Ala Arg Ile Leu Asp Leu Pro Thr Tyr Pro
770 775 780
Phe Gln His Glu Arg Tyr Trp Ala Gly Arg Trp Leu Ala Gly Leu Ala
785 790 795 800
Pro Asp Lys Arg Asp Ala Ala Leu Leu Thr Met Val Arg Asp Ser Ala
805 810 815
Ala Arg Val Leu Gly His Ala Asp Gly Ser Ala Ile Ser Pro Thr Ala
820 825 830
Thr Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
835 840 845
Asn Arg Leu Ala Arg Thr Ala Gly Leu Arg Leu Ala Thr Thr Ile Val
850 855 860
Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala His Leu
865 870 875
<210> 65
<211> 883
<212> PRT
<213> Actinoplanes sp.
<400> 65
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Leu Pro Thr Asp Arg Gly Trp Asp Leu Gly Ala Val Ala
35 40 45
Ala Glu Ser Tyr Cys Val Glu Gly Gly Phe Leu Asp Gly Val Ala Gly
50 55 60
Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met
65 70 75 80
Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ser Leu Glu
85 90 95
Arg Ala Gly Ile Ala Pro Leu Ser Leu Arg Gly Ser Asp Thr Gly Val
100 105 110
Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ala Gly Ala Asp Leu Gly
115 120 125
Gly Phe Gly Thr Thr Ser Gly Ala Ala Ser Val Leu Ser Gly Arg Ile
130 135 140
Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Gly Gln Ala Leu Arg
165 170 175
Asn Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ala
180 185 190
Ala Pro Asp Ile Phe Pro Glu Phe Ala Arg Gln Arg Gly Leu Ala Ser
195 200 205
Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp
210 215 220
Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Gln
225 230 235 240
Ala Asn Gly His Gln Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn
245 250 255
Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln
260 265 270
Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Ser Leu Thr Pro Ala
275 280 285
Asp Val Asp Val Ile Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp
290 295 300
Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Gln Gly Arg Ser
305 310 315 320
Val Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln
325 330 335
Ala Ala Ala Gly Val Thr Gly Val Ile Lys Met Val Met Ala Leu Arg
340 345 350
His Gly Val Val Pro Gln Thr Leu His Val Asp Glu Pro Ser Arg His
355 360 365
Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val Thr Ser Asn Arg Glu
370 375 380
Trp Pro Val Thr Asp Arg Pro Gly Arg Ala Gly Val Ser Ser Phe Gly
385 390 395 400
Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ala Val Pro Ser Asp
405 410 415
Thr Pro Ala Pro Thr Thr Thr Asp Ala Val Leu Pro Leu Val Val Ser
420 425 430
Thr Arg Thr Ala Pro Ala Ala Glu Asp Leu Thr Ala Arg Leu Arg Ala
435 440 445
Tyr Leu Ser Ala Ala Pro Glu Thr Asp Gln Arg Ala Ala Ala Ala Thr
450 455 460
Leu Ala Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Val Leu Gly
465 470 475 480
Glu Asp Thr Ile Thr Gly Val Ala Val Pro Asp Pro Arg Val Val Phe
485 490 495
Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu
500 505 510
Ala Ala Ala Tyr Pro Val Phe Ala Ala Ile His Glu Arg Val Trp Ala
515 520 525
Leu Leu Asp Val Pro Asp Gly Leu Asp Val Asp Asp Thr Gly His Ala
530 535 540
Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ser Gly Leu Leu Glu
545 550 555 560
Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile Gly Glu
565 570 575
Leu Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys
580 585 590
Val Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly
595 600 605
Gly Val Met Val Ala Val Pro Val Pro Glu Ala Glu Ala Arg Ala Val
610 615 620
Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val
625 630 635 640
Val Leu Ser Gly Asp Glu Asp Ala Val Leu Gln Ala Val Ser Gly Phe
645 650 655
Ala Lys Trp Thr Arg Leu Lys Thr Ser His Ala Phe His Ser Ala His
660 665 670
Met Asp Pro Met Leu Asp Glu Phe Arg Ala Val Ala Glu Arg Leu Thr
675 680 685
Tyr Arg Arg Pro Ser Val Glu Met Ala Ala Gly Asp Arg Val Thr Thr
690 695 700
Ala Glu Tyr Trp Val Arg Gln Val Arg Glu Ala Val Arg Phe Gly Asp
705 710 715 720
Gln Thr Thr Ala Tyr Glu Asp Ala Val Phe Val Glu Ile Gly Pro Gly
725 730 735
Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Thr Met Leu His Gly Asp
740 745 750
Thr Glu Arg Glu Ala Ala Leu Thr Gly Leu Ser Gln Leu Phe Val Arg
755 760 765
Gly Val Asp Val Asp Trp Ala Thr Val Ile Glu Asp Thr Thr Ala Arg
770 775 780
Ile Leu Asp Leu Pro Thr Tyr Pro Phe Gln His Glu His Tyr Trp Leu
785 790 795 800
Arg Arg Ala Ala Arg Thr Pro Ala Glu Arg Ala Gln Glu Leu Leu Lys
805 810 815
Leu Val Arg Asp Asn Ala Ala Ala Val Leu Gly His Ala Asp Gly Arg
820 825 830
Thr Val Pro Ala Ala Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu
835 840 845
Ile Ala Val Glu Leu Arg Asn Asn Leu Ala Leu Ala Thr Gly Leu Gln
850 855 860
Leu Pro Thr Thr Ile Val Phe Asp Tyr Pro Thr Ala Ser Ser Leu Ala
865 870 875 880
Glu Arg Leu
<210> 66
<211> 911
<212> PRT
<213> Actinoplanes sp.
<400> 66
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ala Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ala Asp Gly Leu Phe
35 40 45
Asp Pro Asp Leu Ala Val Gly Lys Thr Tyr Cys Val Gln Gly Gly Phe
50 55 60
Leu Gln Thr Ala Ala Glu Phe Asp Pro Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu Lys
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly
115 120 125
Met Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Phe Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Ile Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Ser Leu Thr Pro Ala Asp Ile Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Ser Thr Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Ser Asn Gln Pro Trp Pro Ser Ser Glu Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val Glu Pro Val Gly Ala Glu Ala Gly Leu Val Pro
420 425 430
Val Val Ala Asp Val Leu Pro Trp Val Val Ser Ala Lys Ser Ala Pro
435 440 445
Ala Leu Arg Ala Leu Glu Gln Arg Leu Arg Ala Tyr Glu Ala Ala Asp
450 455 460
Glu Arg Thr Val Val Ala Thr Leu Ala Thr Ala Arg Ala Thr Phe Asp
465 470 475 480
His Arg Ala Val Leu Ile Gly Thr Glu Thr Val Thr Gly Pro Leu Met
485 490 495
Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp
500 505 510
Leu Gly Met Gly Arg Glu Leu Arg Gly Ser Ser Val Val Phe Ala Glu
515 520 525
Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp
530 535 540
Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val
545 550 555 560
Val Gln Pro Val Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp
565 570 575
Gln Ala Ala Gly Val Asn Pro Asp Ala Val Val Gly His Ser Gln Gly
580 585 590
Glu Ile Ala Ala Ala Val Val Ala Gly Ser Leu Ser Leu Arg Asp Gly
595 600 605
Ala Leu Val Val Ala Leu Arg Ser Gln Leu Ile Lys Gly Leu Ala Gly
610 615 620
Arg Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Asp Leu
625 630 635 640
Val Glu Gly Ala Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr Val
645 650 655
Ile Ala Gly Thr Pro Glu Ala Val Glu Gln Val Leu Ala Ala Gln Asp
660 665 670
Ala Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Gln
675 680 685
Val Glu Ala Ile Arg Asp Glu Leu Leu Glu Leu Thr Ala Glu Val Leu
690 695 700
Ser Arg Lys Pro Asp Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp
705 710 715 720
Val Glu Gly Pro Leu Pro Ala Asp Tyr Trp Phe Arg Asn Leu Arg Glu
725 730 735
Gln Val Gly Phe Ala Gln Ala Val Val Thr Leu Gly Asp Ala Val Phe
740 745 750
Val Glu Val Ser Ala Ser Pro Val Leu Ile Gln Ser Met Gly Asp Ala
755 760 765
Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Ser Ala Thr Arg Met
770 775 780
Val Thr Ser Leu Ala Glu Ala Tyr Val Gln Gly Val Gln Val Asn Trp
785 790 795 800
Gly Ala Val Leu Gly Ala Gly Thr Glu Arg Ala Leu Asp Leu Pro Thr
805 810 815
Tyr Pro Phe Gln Arg Gln His Tyr Trp Ala Leu Glu Arg Leu Gly Glu
820 825 830
Arg Ala Gly Thr Glu Arg His Arg Leu Met Leu Glu Val Val Leu Gly
835 840 845
His Ala Ala Ser Val Leu Gly His Ser Ser Ala Ala Ala Leu Glu Pro
850 855 860
Asp Arg Pro Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu
865 870 875 880
Leu Arg Asn His Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr
885 890 895
Met Val Phe Asp Phe Pro Thr Ala Asp Ala Leu Ala Gly His Leu
900 905 910
<210> 67
<211> 934
<212> PRT
<213> Actinoplanes sp.
<400> 67
Glu Pro Ile Ala Val Val Ser Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Asp Thr Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Thr Asp Phe Tyr
35 40 45
Ser Ala Asp Pro Gln Gly Gly Phe Leu Thr Gly Ala Ala Glu Phe Asp
50 55 60
Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Gly Met Asp Pro
65 70 75 80
Gln Gln Arg Leu Leu Leu Glu Thr Thr Trp Glu Ala Ile Glu Arg Ala
85 90 95
Gln Leu Asp Pro Arg Ser Leu Arg Gly Arg Asp Val Gly Val Tyr Val
100 105 110
Gly Gly Ala Ala Gln Gly Tyr Gly Val Gly Phe Ala Gly Glu Pro Arg
115 120 125
Asp Asn Ala Ile Thr Ala Ser Ser Ile Ser Leu Leu Ser Gly Arg Val
130 135 140
Ser Tyr Ala Leu Gly Leu Gln Gly Pro Gly Val Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys Gln Ala Leu Arg
165 170 175
Gln Arg Glu Cys Ser Leu Ala Leu Val Gly Gly Val Ser Val Ile Ala
180 185 190
Thr Pro Asp Val Phe Ala Glu Phe Ser Arg Gln Asn Gly Leu Ala Ala
195 200 205
Asp Gly Arg Cys Lys Ser Phe Gly Ala Ala Ala Asp Gly Thr Gly Trp
210 215 220
Ser Glu Gly Val Gly Met Leu Val Leu Glu Arg Leu Ser Glu Ala Thr
225 230 235 240
Arg His Gly His Arg Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn
245 250 255
Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Gln Ser Gln
260 265 270
Gln Arg Val Ile Arg Gln Ala Leu Ser Asn Ala Gly Leu Ala Ala Ser
275 280 285
Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp
290 295 300
Pro Ile Glu Ala Glu Ala Ile Leu Ala Thr Tyr Gly Gln Asp Arg Ala
305 310 315 320
Ala Pro Ala Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Met
325 330 335
Ala Ala Ser Gly Val Leu Gly Val Ile Lys Met Val Glu Ala Met Arg
340 345 350
His Gly Thr Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Pro His
355 360 365
Val Asp Trp Ser Ala Gly Arg Val Ala Leu Leu Thr Glu Asn Gln Pro
370 375 380
Trp Pro Asp Gly Ala Lys Pro Arg Arg Ala Gly Val Ser Ser Phe Gly
385 390 395 400
Leu Ser Gly Thr Asn Ala His Val Val Leu Glu Gln His Pro Glu Pro
405 410 415
Ala Ser Pro Val Pro Ala Arg Glu Thr Gly Pro Val Pro Trp Val Leu
420 425 430
Ser Ala Gln Ser Pro Lys Ala Leu Gln Glu Gln Ala Gly Arg Leu His
435 440 445
Ala Ala Leu Val Ser Asp Pro Arg Trp His Pro Leu Asp Val Ala Phe
450 455 460
Ser Leu Ala Thr Thr Arg Ser Ala Phe Thr His Arg Thr Ala Val Val
465 470 475 480
Ala Ser Gly Arg Asp Leu Leu Glu Ala Leu Ser Thr Leu Ala Thr Ser
485 490 495
Ala Thr Ala Thr Ser Thr Thr Ala Arg Thr Arg Arg Val Ala Phe Leu
500 505 510
Phe Asp Gly Gln Gly Thr Gln Arg Ala Gly Met Gly Arg Glu Leu Tyr
515 520 525
Glu Arg His Pro Ala Phe Ala Arg Ala Trp Asp Glu Val Ser Ala Ala
530 535 540
Phe Asp Lys His Leu Glu His Pro Leu His Ala Val Tyr Phe Gly Ala
545 550 555 560
Gly Ala Leu Asp Glu Leu Val Asp Asp Thr Gly Tyr Ala Gln Ala Ala
565 570 575
Ile Phe Thr Phe Glu Val Ala Leu Phe Glu Leu Leu His Glu Trp Gly
580 585 590
Val Arg Pro Asp Phe Val Ala Gly His Ser Ile Gly Glu Val Ala Ala
595 600 605
Ala Tyr Val Ser Gly Leu Phe Ser Leu Ala Asp Ala Ala Gln Leu Ile
610 615 620
Val Ala Arg Gly Arg Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Ala
625 630 635 640
Ala Leu Arg Ala Gly Glu Thr Glu Thr Arg Glu Phe Leu Ala Arg Thr
645 650 655
Gly Thr Ala Leu Asp Val Ala Ala Val Asn Ser Pro Glu Ala Val Val
660 665 670
Val Ser Gly Ser Pro Glu Ala Val Ala Glu Phe Thr Ala Ala Trp Thr
675 680 685
Ala Ser Gly Arg Arg Ala Arg Arg Leu Asn Val Asn Arg Ala Phe His
690 695 700
Ser Arg His Val Asp Gly Leu Leu Asp Asp Phe Arg Ala Val Leu Glu
705 710 715 720
Ser Leu Thr Cys Arg Thr Asp Thr Val Leu Pro Met Val Ser Thr Val
725 730 735
Thr Gly Arg Leu Ile Asp Pro Ala Glu Leu Arg Thr Pro Gln Tyr Trp
740 745 750
Leu Ser Gln Val Arg Asp Thr Val Arg Phe Gln Asp Ala Val Ala Glu
755 760 765
Leu Ala Ala Asn Gly Val Gly Val Phe Val Glu Val Gly Pro Ser Ser
770 775 780
Ser Leu Ala Ser Ala Gly Thr Glu Thr Leu Gly Asp Glu Ala His Phe
785 790 795 800
Gln Ala Leu Gln His Ser Arg Thr Pro Ala Asp Pro Ala Leu Leu Thr
805 810 815
Ala Leu Ala Gly Leu His Ser Gly Gly Val Gly Val Asp Trp Glu Lys
820 825 830
Val Leu Val Gly Gly Arg Ala Val Glu Leu Pro Val Tyr Pro Phe Gln
835 840 845
His Arg Ala Tyr Trp Leu Ala Pro Ala Ser Thr Gln Glu Pro Ala Thr
850 855 860
Met Leu Glu Leu Val Arg Phe Glu Val Ala Ala Val Leu Gly Met Pro
865 870 875 880
Asp Pro Ala Ala Val Phe Glu Glu Thr Ser Phe Leu Glu Leu Gly Phe
885 890 895
Asp Ser Leu Ser Ala Val Arg Leu Arg Asn Arg Leu Thr Arg Ser Thr
900 905 910
Gly Val Glu Leu Pro Ala Thr Leu Leu Phe Asp His Pro Thr Pro Ala
915 920 925
Glu Leu Ala Ala His Leu
930
<210> 68
<211> 928
<212> PRT
<213> Streptomyces hygroscopicus
<400> 68
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ser Phe Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn
275 280 285
Ala Gly Leu Ser Ser Met Asp Val Asp Val Val Glu Gly His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ser Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr Pro
420 425 430
Pro Ser Glu Val Ser Val Pro Val Val Ala Ser Asp Val Val Pro Leu
435 440 445
Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu Arg
450 455 460
Leu Arg Gly Tyr Leu Ala Ala Ala Pro Glu Ala Asp Met Gln Ala Val
465 470 475 480
Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala Val
485 490 495
Leu Leu Gly Asp Asp Thr Ile Thr Gly Ile Ala Thr Pro Asp Pro Arg
500 505 510
Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly
515 520 525
Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala Glu
530 535 540
Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser Val
545 550 555 560
Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro Ala
565 570 575
Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly
580 585 590
Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala
595 600 605
Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val
610 615 620
Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala Met
625 630 635 640
Ala Ser Ile Ala Leu Pro Ala Asp Ala Ile Thr Leu Thr Asp Gly Ala
645 650 655
Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr
660 665 670
Pro Gln Ala Val Asp Thr Val Leu Ala Ala Tyr Glu Ala Gln Gly Ile
675 680 685
Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val
690 695 700
Glu Glu Ile His Thr Glu Leu Leu Asp Ala Thr Ala Thr Val Gly Ser
705 710 715 720
Gln Thr Pro Ala Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp Val
725 730 735
Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro
740 745 750
Val Arg Phe Asp Gln Ala Val Thr His Leu Gln Thr Gln Gly Glu Thr
755 760 765
Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met Asn
770 775 780
Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser Pro
785 790 795 800
Thr Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val Gly
805 810 815
Val Asp Trp Pro Ala Val Thr Gly Ala Thr Thr Ala Arg Val Leu Asp
820 825 830
Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Thr Leu Ser Gly
835 840 845
Leu Ala Ala Ala Glu Arg Arg Gln Ala Leu Ala Lys Leu Val Arg Glu
850 855 860
Ser Ala Ala Val Val Leu Gly His Ala Asp Pro Asp Ser Val Pro Ala
865 870 875 880
Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu
885 890 895
Leu Arg Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro Ala Thr
900 905 910
Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu Ala Ala Arg Leu Asp
915 920 925
<210> 69
<211> 901
<212> PRT
<213> Streptomyces hygroscopicus
<400> 69
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Ser Leu Tyr
35 40 45
Asp Pro Ile Leu Gly Ala Ser Gly Glu Phe Tyr Ser Ala Gln Gly Gly
50 55 60
Phe Leu Asp Arg Ala Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Glu Ala Ser Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Ser Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala
195 200 205
Arg Glu Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Ala Thr Glu Lys Leu Pro Trp Pro Ala Ser Asp Arg Val Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Glu Val Val Ser Pro Ser Glu Ser Ser Gly
420 425 430
Pro Asn Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr
435 440 445
Ser Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala
450 455 460
Ala Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly
465 470 475 480
Ser Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu
485 490 495
Val Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val
515 520 525
Phe Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro
545 550 555 560
Ala Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp
565 570 575
Gly Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala
580 585 590
Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu
595 600 605
Val Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val
610 615 620
Met Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val
625 630 635 640
Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu
645 650 655
Ser Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly
660 665 670
Arg Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met
675 680 685
Asp Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr
690 695 700
Arg Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro
705 710 715 720
Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln
725 730 735
Val Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly
740 745 750
Gly Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu
755 760 765
Asp Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg
770 775 780
Gly Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro
785 790 795 800
Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Thr Ala
805 810 815
Ser Trp Leu Val Ala Leu Glu Pro Glu Glu Arg Gly Gln Ala Leu Leu
820 825 830
Arg Met Val Arg Glu Gly Ala Ser Val Val Leu Gly His Ala Asp Ala
835 840 845
Arg Ala Val Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser
850 855 860
Leu Thr Ala Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu
865 870 875 880
Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu
885 890 895
Ala Ala Arg Leu Asp
900
<210> 70
<211> 901
<212> PRT
<213> Streptomyces hygroscopicus
<400> 70
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe
50 55 60
Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly
115 120 125
Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Leu Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala
210 215 220
Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu
370 375 380
Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met
420 425 430
Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser
435 440 445
Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Val
450 455 460
Ala Gly Ser Glu Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly
465 470 475 480
Ser Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu
485 490 495
Val Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser
500 505 510
Gly Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val
515 520 525
Phe Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp
530 535 540
Val Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro
545 550 555 560
Ala Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp
565 570 575
Gly Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala
580 585 590
Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu
595 600 605
Val Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val
610 615 620
Met Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val
625 630 635 640
Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu
645 650 655
Ser Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly
660 665 670
Arg Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met
675 680 685
Asp Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr
690 695 700
Arg Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro
705 710 715 720
Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln
725 730 735
Val Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly
740 745 750
Gly Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu
755 760 765
Asp Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg
770 775 780
Gly Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Ala Pro
785 790 795 800
Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Thr Gln
805 810 815
Thr Trp Leu Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu
820 825 830
Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala
835 840 845
Gly Met Ile Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser
850 855 860
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu
865 870 875 880
Ser Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu
885 890 895
Ala Asp Arg Leu Asp
900
<210> 71
<211> 926
<212> PRT
<213> Streptomyces hygroscopicus
<400> 71
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Ala Gly Tyr Gly
115 120 125
Gly Asp Arg Glu Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser Val Leu
130 135 140
Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr
145 150 155 160
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly
165 170 175
Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Ala
180 185 190
Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Arg
195 200 205
Gly Leu Ser Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala Asp
210 215 220
Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu
225 230 235 240
Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Gly
245 250 255
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn
260 265 270
Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly
275 280 285
Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr
290 295 300
Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly
305 310 315 320
Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile
325 330 335
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
340 345 350
Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val Asp Glu
355 360 365
Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu Val Thr
370 375 380
Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala Gly Val
385 390 395 400
Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
405 410 415
Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr Pro Pro Ser
420 425 430
Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro Leu Val Val
435 440 445
Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu Arg Leu Arg
450 455 460
Gly Tyr Leu Ala Ala Ala Ser Asp Val Asp Met Ala Ala Ala Ala Ser
465 470 475 480
Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu
485 490 495
Gly Asp Asp Thr Ile Thr Gly Ile Ala Thr Pro Asp Pro Arg Val Val
500 505 510
Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Val
515 520 525
Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala
530 535 540
Ala Ala Leu Gly Glu Phe Val Asp Trp Asp Leu Phe Ser Val Leu Asp
545 550 555 560
Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp
565 570 575
Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser
580 585 590
Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
595 600 605
Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Ala Leu
610 615 620
Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala Met Ala Ser
625 630 635 640
Ile Ala Leu Pro Ala Gly Asp Val Ala Leu Val Asp Gly Ala Trp Ile
645 650 655
Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Gln
660 665 670
Ala Val Asp Thr Val Leu Ala Ala His Glu Ala Gln Gly Ile Arg Val
675 680 685
Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu
690 695 700
Ile His Ala Glu Leu Leu Asp Ala Thr Ala Ala Val Gly Ser Gln Ala
705 710 715 720
Pro Ala Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp Val Glu Gly
725 730 735
Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg
740 745 750
Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe
755 760 765
Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp
770 775 780
Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser Pro Ala Arg
785 790 795 800
Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp
805 810 815
Trp Pro Ala Val Thr Gly Ala Thr Thr Ser Arg Val Asp Leu Pro Thr
820 825 830
Tyr Pro Phe Gln His Gln Arg Tyr Trp Ala Trp Leu Ala Gly Leu Ala
835 840 845
Pro Glu Ala Arg Gly Gln Ala Leu Leu Lys Val Val Arg Glu Ser Ala
850 855 860
Ala Val Val Leu Gly His Thr Gly Ala Asp Thr Val Pro Val Thr Ala
865 870 875 880
Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg
885 890 895
Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro Val Thr Ala Val
900 905 910
Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu Asp
915 920 925
<210> 72
<211> 923
<212> PRT
<213> Streptomyces hygroscopicus
<400> 72
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Arg Asp Val
20 25 30
Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Thr Tyr Cys Lys Arg Gly Gly Phe
50 55 60
Leu Asp Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ala Asn Glu Tyr Gly
115 120 125
Ala Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Gly Phe Ala Arg
195 200 205
Glu Arg Gly Leu Ala Val Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala
210 215 220
Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Ser Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Lys Gln Pro Trp Pro Thr Ser Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Asp Glu Ala Leu Val Pro
420 425 430
Val Val Ala Ser Asp Val Met Pro Leu Val Val Ser Ala Lys Thr Pro
435 440 445
Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Ala His Leu Ala Ala
450 455 460
Ala Pro Glu Ala Asp Met Gln Ala Val Ala Ser Thr Leu Ala Ala Thr
465 470 475 480
Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile
485 490 495
Thr Gly Val Ala Ala Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly
500 505 510
Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Val Leu Arg Glu Thr Ser
515 520 525
Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala Ala Ala Leu Arg Glu
530 535 540
Phe Val Asp Trp Asp Leu Phe Ser Val Leu Asp Asp Pro Thr Val Val
545 550 555 560
Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser
565 570 575
Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile
580 585 590
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val
595 600 605
Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile
610 615 620
Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala
625 630 635 640
Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly
645 650 655
Thr Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val
660 665 670
Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val
675 680 685
Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile His Thr Glu Leu
690 695 700
Leu Asp Ala Thr Ala Thr Val Gly Ser Gln Thr Pro Ala Val Pro Trp
705 710 715 720
Leu Ser Thr Val Asp Asn Thr Trp Ile Ser Arg Pro Leu Asp Thr Asp
725 730 735
Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val
740 745 750
Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala
755 760 765
Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Val Thr Val Ala
770 775 780
Thr Leu Arg Arg Asp Asp Asp Ser Pro Thr Arg Ile Leu Thr Ala Leu
785 790 795 800
Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr
805 810 815
Gly Ala Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg
820 825 830
Gln Arg Tyr Trp Thr Ala Ser Trp Leu Ala Gly Leu Ala Pro Glu Ala
835 840 845
Arg Gly Gln Ala Leu Leu Lys Val Val Arg Glu Ser Thr Ala Val Val
850 855 860
Leu Gly His Val Asp Thr Glu Thr Val Pro Ala Thr Ala Pro Phe Lys
865 870 875 880
Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg Asn Gly Leu
885 890 895
Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr
900 905 910
Pro Thr Pro Ala Ala Leu Ala Ala Arg Leu Asp
915 920
<210> 73
<211> 898
<212> PRT
<213> Streptomyces hygroscopicus
<400> 73
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Ile Gly Val Phe Met Gly Ala Met Ala Asn Glu Tyr Gly
115 120 125
Ala Gly Ala Asp Phe Gly Ala Phe Gly Met Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Arg Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu
370 375 380
Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met
420 425 430
Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser
435 440 445
Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Ala
450 455 460
Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly Ser
465 470 475 480
Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu Val
485 490 495
Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser Gly
500 505 510
Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val Phe
515 520 525
Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp Val
530 535 540
Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro Ala
545 550 555 560
Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp Gly
565 570 575
Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala Ala
580 585 590
Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu Val
595 600 605
Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val Met
610 615 620
Val Ser Val Ser Val Ser Glu Asp Arg Ala Arg Ala Ala Leu Val Glu
625 630 635 640
Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser
645 650 655
Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly Arg
660 665 670
Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Asp
675 680 685
Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr Arg
690 695 700
Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro Glu
705 710 715 720
Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val
725 730 735
Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly Gly
740 745 750
Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu Asp
755 760 765
Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg Gly
770 775 780
Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro Val
785 790 795 800
Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu
805 810 815
Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val
820 825 830
Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val
835 840 845
Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala
850 855 860
Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro
865 870 875 880
Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg
885 890 895
Leu Asp
<210> 74
<211> 898
<212> PRT
<213> Streptomyces hygroscopicus
<400> 74
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Ala Val Lys Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Asn Gly Tyr Gly
115 120 125
Thr Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Thr Gly Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ser Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Ala Arg Glu Arg Gln Pro Trp Pro Val Ala Gly Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Val His Ser Val Glu Thr Asp Glu Thr Ala Pro Met
420 425 430
Ala Leu Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Ser
435 440 445
Gly Ala Leu Val Asp Ile Glu Glu Arg Leu Arg Gly Tyr Leu Ala Ala
450 455 460
Val Pro Gly Val Asp Leu Gly Ala Val Ala Ser Val Leu Ala Gly Ser
465 470 475 480
Arg Ser Val Phe Gly His Arg Gly Val Leu Val Gly Gly Glu Leu Val
485 490 495
Ser Gly Val Ala Leu Ser Gly Pro Arg Val Val Phe Val Phe Ser Gly
500 505 510
Gln Gly Ser Gln Cys Val Gly Met Gly Glu Arg Leu Ala Gly Val Phe
515 520 525
Pro Val Phe Ala Glu Val Tyr Gly Arg Val Trp Asp Leu Leu Asp Val
530 535 540
Pro Gly Ser Gly Leu Gly Val Asp Asp Thr Gly Phe Val Gln Pro Ala
545 550 555 560
Leu Phe Ala Leu Gln Val Gly Leu Phe Gly Leu Leu Glu Ser Trp Gly
565 570 575
Val Arg Pro Glu Val Val Val Gly His Ser Val Gly Glu Val Ala Ala
580 585 590
Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Val Leu Val
595 600 605
Ser Ala Arg Ala Arg Leu Met Gln Gly Leu Pro Gly Gly Gly Val Met
610 615 620
Val Ser Val Ser Val Ser Glu Glu Arg Ala Arg Ala Ala Leu Val Glu
625 630 635 640
Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser
645 650 655
Gly Asp Glu Ala Ala Val Val Gly Val Ala Glu Gly Leu Gly Gly Arg
660 665 670
Trp Arg Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Asp
675 680 685
Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gly Leu Glu Tyr Arg
690 695 700
Glu Pro Arg Ile Val Met Ala Gly Gly Ala Gly Val Val Ser Pro Glu
705 710 715 720
Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val
725 730 735
Ala Ala Tyr Gln Gly Asp Ala Val Phe Val Glu Val Gly Pro Gly Gly
740 745 750
Ser Leu Ala Arg Leu Ile Asp Gly Val Ala Val Gly Asp Gly Glu Asp
755 760 765
Glu Val Arg Ala Ala Val Met Ala Val Ala Glu Leu Phe Val Arg Gly
770 775 780
Val Asp Val Asp Trp Pro Ala Val Val Gly Thr Thr Ala Thr Pro Val
785 790 795 800
Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu
805 810 815
Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val
820 825 830
Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val
835 840 845
Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala
850 855 860
Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro
865 870 875 880
Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg
885 890 895
Leu Asp
<210> 75
<211> 923
<212> PRT
<213> Streptomyces hygroscopicus
<400> 75
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe
50 55 60
Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly
115 120 125
Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Ala Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Arg Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Glu Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Ala Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Gln Leu
370 375 380
Ala Thr Glu Lys Gln Pro Trp Pro Ala Ser Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Asp Glu Pro Ser Ala Pro
420 425 430
Ile Val Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Leu
435 440 445
Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Gly Tyr Leu Ala Ala
450 455 460
Ala Ser Asp Val Asp Met Ala Ala Val Ala Ser Thr Leu Ala Ala Thr
465 470 475 480
Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile
485 490 495
Thr Gly Ile Ala Thr Pro Gly Pro Arg Val Val Phe Val Phe Pro Gly
500 505 510
Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Thr Leu Arg Glu Thr Ser
515 520 525
Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu Arg Glu
530 535 540
Phe Val Asp Trp Asp Leu Phe Ser Ile Leu Asp Asp Pro Thr Val Val
545 550 555 560
Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser
565 570 575
Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile
580 585 590
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val
595 600 605
Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile
610 615 620
Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala
625 630 635 640
Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly
645 650 655
Thr Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val
660 665 670
Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val
675 680 685
Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile His Thr Glu Leu
690 695 700
Leu Asp Ala Thr Thr Thr Ile Asn Pro Arg Thr Pro Ala Val Pro Trp
705 710 715 720
Leu Ser Thr Val Asp Asn Thr Trp Ile Ser Arg Pro Leu Asp Thr Asp
725 730 735
Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val
740 745 750
Thr Leu Leu Gln Thr Arg Gly Glu Thr Val Phe Ile Glu Val Ser Ala
755 760 765
Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Ile Thr Val Ala
770 775 780
Thr Leu Arg Arg Asp Asp Asp Ser Pro Ala Arg Ile Leu Thr Ala Leu
785 790 795 800
Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr
805 810 815
Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln
820 825 830
His Gln Arg Tyr Trp Ala Thr Ala Trp Leu Ala Gly Leu Ala Pro Ala
835 840 845
Glu Arg Gly Glu Ala Leu Leu Lys Val Val Ser Asp Thr Val Ala Arg
850 855 860
Val Leu Gly His Ala Asp Gly Arg Thr Ile Pro Ala Thr Ala Ala Phe
865 870 875 880
Lys Glu Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg
885 890 895
Leu Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp
900 905 910
Tyr Pro Ser Pro Gly Ala Leu Ala Gly Trp Leu
915 920
<210> 76
<211> 930
<212> PRT
<213> Streptomyces hygroscopicus
<400> 76
Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Leu Glu Gly Leu Tyr
35 40 45
Asp Pro Ala Ser Asp Glu Pro Gly Val Leu Tyr Cys Asp Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ser Phe Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp
210 215 220
Ala Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ser Ser Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr
420 425 430
Pro Pro Ser Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro
435 440 445
Leu Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu
450 455 460
Arg Leu Arg Gly Tyr Leu Ala Ala Ala Pro Glu Ala Asp Met Gln Ala
465 470 475 480
Val Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala
485 490 495
Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala Ala Ser Gly Pro
500 505 510
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
515 520 525
Gly Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Gln Met Ala
530 535 540
Glu Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser
545 550 555 560
Val Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro
565 570 575
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala
580 585 590
Gly Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala
595 600 605
Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile
610 615 620
Val Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala
625 630 635 640
Met Ala Ser Ile Ala Leu Pro Ala Gly Ala Ile Thr Leu Thr Asp Gly
645 650 655
Ala Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly
660 665 670
Thr Pro Gln Ala Val Asp Ala Val Leu Ala Ala Tyr Glu Ala Gln Gly
675 680 685
Ile Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln
690 695 700
Val Glu Glu Ile Arg Ala Glu Leu Leu Asp Ala Thr Ala Thr Val Gly
705 710 715 720
Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Ala Trp
725 730 735
Val Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu
740 745 750
Pro Val Arg Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu
755 760 765
Thr Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met
770 775 780
Asn Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser
785 790 795 800
Pro Ala Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val
805 810 815
Gly Val Asp Trp Pro Ala Ala Thr Gly Ala Thr Thr Ser Arg Val Asp
820 825 830
Leu Pro Thr Tyr Pro Phe Gln His Gln Arg Tyr Trp Thr Gln Thr Leu
835 840 845
Ser Gly Leu Ala Ala Ala Glu Arg Arg Gln Ala Leu Ala Lys Leu Val
850 855 860
Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Pro Asp Ser Val
865 870 875 880
Pro Ala Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala
885 890 895
Val Glu Leu Arg Asn Ser Leu Gly Arg Ser Thr Gly Leu Arg Leu Pro
900 905 910
Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Asp Ala Leu Ala Ala Arg
915 920 925
Leu Asp
930
<210> 77
<211> 930
<212> PRT
<213> Streptomyces hygroscopicus
<400> 77
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Ser Leu Tyr
35 40 45
Asp Pro Ile Leu Gly Ala Ser Gly Glu Phe Tyr Ser Ala Gln Gly Gly
50 55 60
Phe Leu Asp Arg Ala Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Glu Ala Ser Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr
115 120 125
Gly Thr Gly Ser Asp Phe Gly Ala Phe Gly Ala Thr Ser Ser Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Ile Thr Val Met Ser Thr Pro Leu Thr Phe Ala Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Ser Lys Ala Phe Ser Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Glu Ala Ala Ser Ala Ser Glu Pro Val Thr
420 425 430
Pro Pro Ser Glu Ala Ser Val Pro Val Val Ala Ser Asp Val Val Pro
435 440 445
Leu Val Val Ser Ala Lys Thr Pro Gly Ala Leu Thr Asp Ile Glu Glu
450 455 460
Arg Leu Arg Gly Tyr Leu Ala Ala Ala Ser Asp Val Asp Met Ala Val
465 470 475 480
Val Ala Ser Thr Leu Ala Ala Thr Arg Ser Val Phe Glu His Arg Ala
485 490 495
Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala Ala Ser Gly Pro
500 505 510
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
515 520 525
Gly Ser Val Leu Arg Glu Thr Ser Pro Val Phe Ala Gly Arg Met Ala
530 535 540
Glu Cys Ala Ala Ala Leu Arg Glu Phe Val Asp Trp Asp Leu Phe Ser
545 550 555 560
Val Leu Asp Asp Pro Thr Val Val Asp Arg Val Asp Val Leu Gln Pro
565 570 575
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala
580 585 590
Gly Val Ser Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala
595 600 605
Ala Ala Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile
610 615 620
Val Ala Leu Arg Ser Lys Leu Ile Gly Ala Arg Leu Gly His Gly Ala
625 630 635 640
Met Ala Ser Ile Ala Leu Pro Ala Asp Ala Ile Thr Leu Thr Asp Gly
645 650 655
Ala Trp Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Ile Ala Gly
660 665 670
Thr Pro Gln Ala Val Asp Ala Val Leu Ala Ala Tyr Glu Ala Gln Gly
675 680 685
Ile Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln
690 695 700
Val Glu Glu Ile Arg Ala Glu Leu Leu Asp Ala Thr Ala Thr Val Gly
705 710 715 720
Ser Gln Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Asn Thr Trp
725 730 735
Ile Ser Arg Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu
740 745 750
Pro Val Arg Phe Asp Gln Ala Val Thr Leu Leu Gln Thr Gln Gly Glu
755 760 765
Thr Val Phe Ile Glu Val Ser Ala Ser Pro Ala Leu Thr Pro Ala Met
770 775 780
Asn Asp Asp Ala Ile Thr Val Ala Thr Leu Arg Arg Asp Asp Asp Ser
785 790 795 800
Pro Ala Arg Ile Leu Thr Ala Leu Ala Glu Ala Phe Val Gln Gly Val
805 810 815
Gly Val Asp Trp Pro Ala Val Thr Gly Ala Thr Thr Ala Arg Val Leu
820 825 830
Asp Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Trp Leu
835 840 845
Thr Gly Leu Ala Ser Glu Asp Arg Arg Gln Ala Leu Leu Lys Val Val
850 855 860
Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg Ala Val
865 870 875 880
Glu Val Asp Arg Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala
885 890 895
Val Gln Val Arg Asn Asn Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro
900 905 910
Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg
915 920 925
Leu Asp
930
<210> 78
<211> 923
<212> PRT
<213> Streptomyces hygroscopicus
<400> 78
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Val
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Gln Gly Tyr Phe
50 55 60
Leu Asp Asp Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly
115 120 125
Ile Gly Ala Asp His Ser Gly Phe Gly Met Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Ala Thr Val Leu Ala Thr Pro Tyr Gly Phe Val Glu Ile Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp Ala
210 215 220
Ala Asp Gly Met Ser Phe Ser Glu Gly Ala Gly Val Leu Val Leu Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asn Arg Glu Arg Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr His Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Ala Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Val Ala Glu Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Leu Glu Thr Gly Glu Pro Ser Ala Pro
420 425 430
Ile Val Ala Ser Asp Val Val Pro Leu Val Val Ser Ala Lys Thr Pro
435 440 445
Asp Ala Leu Thr Asp Ile Glu Asp Arg Leu Arg Ala His Leu Ala Ala
450 455 460
Ala Pro Glu Ala Asp Met Gln Ala Val Ala Ser Thr Leu Ala Ala Thr
465 470 475 480
Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile
485 490 495
Thr Gly Ile Ala Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly
500 505 510
Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Thr Leu Arg Glu Thr Ser
515 520 525
Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Thr Ala Leu Arg Glu
530 535 540
Phe Val Asp Trp Asp Leu Phe Ser Ile Leu Asp Asp Pro Thr Val Val
545 550 555 560
Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser
565 570 575
Leu Ala Ala Val Trp Gln Glu Ala Gly Val Ser Pro Asp Ala Val Ile
580 585 590
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val
595 600 605
Ser Leu Gln Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Lys Leu Ile
610 615 620
Ala His Leu Ala Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala
625 630 635 640
Asp Ala Ile Thr Leu Thr Asp Gly Ala Trp Ile Ala Ala His Asn Gly
645 650 655
Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Gln Ala Val Asp Thr Val
660 665 670
Leu Ala Thr His Glu Ala Gln Gly Ile Arg Val Arg Arg Ile Thr Val
675 680 685
Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Ala Glu Leu
690 695 700
Leu Asp Ala Thr Ala Thr Val Gly Ser Gln Ala Pro Val Val Pro Trp
705 710 715 720
Leu Ser Thr Val Asp Gly Ala Trp Val Glu Gly Pro Leu Asp Ala Asp
725 730 735
Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Asp Gln Ala Val
740 745 750
Thr Leu Leu Gln Thr Gln Gly Glu Thr Val Phe Ile Glu Val Ser Ala
755 760 765
Ser Pro Ala Leu Thr Pro Ala Met Asn Asp Asp Ala Val Thr Val Ala
770 775 780
Thr Leu Arg Arg Asp Asp Asp Ser Pro Thr Arg Ile Leu Thr Ala Leu
785 790 795 800
Ala Glu Ala Phe Val Gln Gly Val Gly Val Asp Trp Pro Ala Val Thr
805 810 815
Gly Ala Thr Thr Thr Pro Val Asp Leu Pro Thr Tyr Pro Phe Gln Arg
820 825 830
Gln Arg Tyr Trp Thr Ala Ser Asp Arg Leu Ser Gly Arg Thr Ser Gly
835 840 845
Asp Gln His Arg Ile Met Leu Glu Leu Val Leu Gly His Ala Ala Ser
850 855 860
Val Leu Gly His Gly Ala Ala Asp Ala Val Ala Ala Asp Lys Pro Phe
865 870 875 880
Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn His
885 890 895
Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp
900 905 910
His Pro Thr Ala Asp Asp Leu Ala Arg Arg Leu
915 920
<210> 79
<211> 965
<212> PRT
<213> Streptomyces hygroscopicus
<400> 79
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Asp Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Ala Asp Leu Tyr
35 40 45
Ser Pro Asp Pro Ala Gly Tyr Lys Ser Tyr Cys Val Gln Gly Gly Phe
50 55 60
Leu Asp Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Ala
85 90 95
Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Arg
100 105 110
Gly Arg Ser Val Gly Val Phe Val Gly Gly Ala Ser Gln Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Asp Gln Gln Gln Ser Asn Ala Ile Thr Gly Gly Ser
130 135 140
Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu
180 185 190
Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ser
210 215 220
Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val
225 230 235 240
Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val His Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Ala Ser Gln Gln Lys Val Ile Arg Gln Ala Leu
275 280 285
Ala Asn Ala Gly Leu Ala Ala Ser Glu Val Asp Ala Val Glu Ala His
290 295 300
Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Ala Ala Pro Val Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val
340 345 350
Ile Lys Met Val Glu Ser Met Arg His Gly Leu Leu Pro Arg Thr Leu
355 360 365
Asn Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val
370 375 380
Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Ala Asp Val Gly Pro Arg
385 390 395 400
Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Ser Asn Ala His Val
405 410 415
Val Leu Glu Gln Tyr Gly Glu Pro Ala Gly Pro Asp Leu Ser Asp Leu
420 425 430
Thr Asn Thr Arg Ala Val Asn Ala Ala Asp Ala Pro Asp Arg Arg Gln
435 440 445
Pro Val Pro Leu Met Leu Ser Ala Arg Ser Gln Arg Ala Leu Arg Glu
450 455 460
Gln Ala Gly Arg Leu His Ala Ala Leu Ala Gly Ala Pro Asp Trp Arg
465 470 475 480
Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser His Phe Thr
485 490 495
His Arg Ala Val Ala Val Gly Ser Gly Arg Glu Leu Leu Arg Ala Leu
500 505 510
Ser Lys Leu Ala Asp Gly Ala Asp Trp Pro Ala Leu Thr Thr Arg Ile
515 520 525
Ala Lys Ser Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Thr Gln
530 535 540
Arg Leu Gly Met Gly Ser Gly Leu Tyr Ala Gly Phe Pro Val Phe Ala
545 550 555 560
Gly Val Trp Asp Gln Val Ser Ala Ala Phe Asp Lys His Leu Asp His
565 570 575
Ser Leu Thr Asp Val Phe Leu Gly Arg Asp Asp Arg Pro Ala Ala Ala
580 585 590
Glu Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Leu Phe Thr Leu
595 600 605
Glu Val Ala Leu Phe Arg Leu Leu Glu Glu Trp Gly Val Arg Pro Asp
610 615 620
Phe Leu Ala Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr Ala Gly
625 630 635 640
Gly Met Phe Ser Leu Glu Asp Val Thr Ala Leu Ile Val Ala Arg Gly
645 650 655
Glu Ala Leu Arg Leu Ala Pro Pro Gly Ala Met Leu Ala Leu Arg Ala
660 665 670
Ser Glu Glu Glu Val Arg Glu Phe Leu Gly Arg Thr Gly Ala Glu Leu
675 680 685
Asp Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Val Ser Gly Ala
690 695 700
Ser Glu Ala Val Ala Asp Phe Arg Ala Arg Trp Thr Ala Ala Gly Arg
705 710 715 720
Lys Ala Arg Glu Leu Asn Val Ser Arg Ala Phe His Ser Arg His Val
725 730 735
Glu Ala Gly Leu Gly Arg Phe Arg Glu Val Leu Glu Ser Leu Thr Phe
740 745 750
Gly Thr Pro Val Leu Pro Ile Val Ser Thr Val Thr Gly Gln Leu Val
755 760 765
Asp Pro Val Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg
770 775 780
Gln Pro Val Leu Phe Gln Asp Ala Leu Arg Glu Leu Ser Gly Gln Gly
785 790 795 800
Val Asn Thr Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser Ala
805 810 815
Gly Leu Glu Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Gln Gln
820 825 830
Pro Arg Ser Pro Gln Asp Val Gly Leu Met Thr Ala Val Ala Glu Leu
835 840 845
His Ala Gly Gly Thr Ala Val Asp Trp Ala Lys Ala Leu Ala Gly Gly
850 855 860
Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Glu Ser Tyr Trp
865 870 875 880
Leu Ala Pro Ala Asp Tyr Ala Tyr Pro Glu Glu Pro Gly Thr Met Leu
885 890 895
Glu Leu Val Arg Leu Glu Ala Ala Lys Val Leu Gly Ile Thr Glu Pro
900 905 910
Asp Thr Ile Leu Glu Glu Thr Ser Phe Leu Asp Leu Gly Phe Asp Ser
915 920 925
Leu Gly Thr Met Arg Leu Arg Asn Arg Leu Ser Glu Val Thr Glu Leu
930 935 940
Asp Leu Pro Ala Thr Leu Leu Phe Asp Asn Pro Ser Pro Ala Glu Leu
945 950 955 960
Ala Ala Tyr Leu Asp
965
<210> 80
<211> 908
<212> PRT
<213> Streptomyces filamentosus
<400> 80
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ala Met Arg
100 105 110
Gly Ser His Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Met Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Arg Leu Ala Pro Asn Glu Ile Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro Ala
420 425 430
Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu
485 490 495
Thr Val Thr Gly Pro Gly Thr Gly Ala Gly Ser Gly Val Ala Val Ser
500 505 510
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala
515 520 525
Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Glu Ile
530 535 540
His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro Gly Leu Asp
545 550 555 560
Thr Asp Glu Thr Gly Tyr Ala Gln Pro Ser Leu Phe Ala Leu Gln Val
565 570 575
Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Val
580 585 590
Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu
595 600 605
Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu
610 615 620
Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val Pro Val Ser
625 630 635 640
Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu Ile Ala Ala
645 650 655
Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu Thr Ala Val
660 665 670
Leu Glu Thr Ala Ala Ala Leu Gly Arg Ser Thr Arg Leu Thr Thr Ser
675 680 685
His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp Glu Phe Arg
690 695 700
Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile Pro Met Ala
705 710 715 720
Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg
725 730 735
Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu Asn Ala Val
740 745 750
Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly
755 760 765
Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala
770 775 780
Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp Pro Ala Val
785 790 795 800
Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Met Pro Thr Tyr Ala Phe
805 810 815
Gln His Gln Arg Tyr Trp Thr Thr Trp Leu Ala Gly Leu Ala Pro Glu
820 825 830
Glu Arg Lys Gln Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Ala
835 840 845
Val Leu Gly His Ala Gly Ala Asp Thr Val Pro Val Thr Ala Ala Phe
850 855 860
Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser
865 870 875 880
Leu Gly Lys Ser Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp
885 890 895
Tyr Pro Asn Pro Thr Thr Leu Ala Ala Arg Leu Asp
900 905
<210> 81
<211> 902
<212> PRT
<213> Streptomyces filamentosus
<400> 81
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly
50 55 60
Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Met
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Leu Gly Ala Phe Gly Met Thr Ser Ala Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp
275 280 285
Asn Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala
305 310 315 320
Ala Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Asp Leu Pro Val Val Glu Thr Glu Glu Thr Pro
420 425 430
Ala Pro Val Val Thr Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Pro Ala Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ser Tyr Leu
450 455 460
Thr Ser Met Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu
485 490 495
Thr Val Thr Gly Pro Gly Thr Gly Val Ala Val Ser Gly Pro Arg Val
500 505 510
Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu
515 520 525
Gln Leu Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Gln Gln Val
530 535 540
Trp Asp Leu Leu Asp Val Pro Asp Pro Gly Leu Gly Ala Asp Glu Thr
545 550 555 560
Gly Phe Ala Gln Pro Ser Leu Phe Ala Leu Gln Val Ala Leu Phe Gly
565 570 575
Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser
580 585 590
Val Gly Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Arg
595 600 605
Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Thr Leu
610 615 620
Pro Thr Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Lys Gln Ala
625 630 635 640
Gln Ala Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro
645 650 655
Ser Ser Val Val Leu Thr Gly Asp Glu Thr Ala Val Leu Glu Thr Ala
660 665 670
Ala Ala Leu Gly Lys Ser Thr Arg Leu Thr Thr Ser His Ala Phe His
675 680 685
Ser Ala Arg Met Glu Pro Val Leu Asp Gln Phe Arg Thr Val Ala Glu
690 695 700
Thr Leu Asp Tyr Arg Thr Pro His Ile Pro Met Ala Ala Gly Asp Ala
705 710 715 720
Val Val Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg Asp Thr Val Arg
725 730 735
Phe Gly Asp Gln Val Ala Ala His Glu Asn Ala Val Phe Val Glu Ile
740 745 750
Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly Ile Ala Met Leu
755 760 765
His Gly Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala Leu Ala Thr Leu
770 775 780
His Thr His Gly Val Asn Ile His Trp Pro Ala Val Ile Gly Ala Thr
785 790 795 800
Thr Thr Pro Val Asp Leu Pro Thr Tyr Ala Phe Glu Arg Gln Arg Tyr
805 810 815
Trp Ala Trp Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu
820 825 830
Leu Lys Thr Val Arg Asp Asn Ala Ala Lys Val Leu Gly His Ala Asp
835 840 845
Ala Arg Asp Ile Ala Val Asn Thr Ala Phe Arg Asp Leu Gly Leu Asp
850 855 860
Ser Leu Thr Ala Val Gln Val Arg Asn Ser Leu Ala Lys Ala Thr Gly
865 870 875 880
Leu Arg Leu Pro Thr Thr Thr Val Phe Asp Tyr Pro Asn Pro Thr Ala
885 890 895
Leu Ala Thr His Leu Asp
900
<210> 82
<211> 901
<212> PRT
<213> Streptomyces filamentosus
<400> 82
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Ala His Asn Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr Gly
115 120 125
Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ser Ser Ala Leu Arg Gln Asp Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Asp Asn
275 280 285
Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Asp Leu Pro Val Val Glu Thr Glu Glu Val Pro Ala
420 425 430
Pro Pro Val Val Ala Ser Asp Leu Met Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Ala Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Pro Gly Val Ala Val Ser Gly Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln Leu
515 520 525
Ala Ala Val Phe Pro Val Phe Ala Glu Ile His Gln Gln Val Trp Asp
530 535 540
Leu Leu Asp Val Pro Asp Pro Gly Leu Asp Thr Asp Glu Thr Gly Phe
545 550 555 560
Ala Gln Pro Ser Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu
565 570 575
Glu Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly
580 585 590
Glu Ile Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Arg Asp Ala
595 600 605
Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Thr Leu Pro Thr
610 615 620
Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Lys Gln Ala Gln Ala
625 630 635 640
Ala Leu Thr Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser
645 650 655
Val Val Leu Thr Gly Asp Glu Thr Ala Val Leu Glu Thr Ala Ala Ala
660 665 670
Leu Gly Lys Ser Thr Arg Leu Thr Thr Ser His Ala Phe His Ser Ala
675 680 685
Arg Met Glu Pro Val Leu Asp Gln Phe Arg Thr Val Ala Glu Thr Leu
690 695 700
Asp Tyr Arg Thr Pro His Ile Pro Met Ala Ala Gly Asp Ala Val Val
705 710 715 720
Thr Pro Glu Tyr Trp Val Arg Gln Ile Arg Asp Thr Val Arg Phe Gly
725 730 735
Asp Gln Val Ala Ala His Glu Asn Ala Val Phe Val Glu Ile Gly Pro
740 745 750
Asp Arg Thr Leu Ser Arg Leu Thr Asp Gly Ile Ala Met Leu His Gly
755 760 765
Asp Asn Glu Thr Gln Thr Ala Ile Thr Ala Leu Ala Thr Leu His Thr
770 775 780
His Gly Val Asn Ile His Trp Pro Thr Ile Val Gly Thr Thr Thr Pro
785 790 795 800
Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr
805 810 815
Ser Trp Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu
820 825 830
Lys Thr Val Arg Asp Ser Ala Ala Ala Val Leu Gly His Val Gly Thr
835 840 845
Asp Thr Val Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser
850 855 860
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu
865 870 875 880
Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Ala Leu
885 890 895
Ala Ala Arg Leu Asp
900
<210> 83
<211> 930
<212> PRT
<213> Streptomyces filamentosus
<400> 83
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Leu Gly Arg Thr Tyr Thr Val Gln Gly Gly Phe
50 55 60
Leu Asp Ile Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro Arg
65 70 75 80
Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala Ser
85 90 95
Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Met Arg Gly
100 105 110
Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr Gly Ala
115 120 125
Glu His Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val Leu Ser
130 135 140
Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Leu Thr Val
145 150 155 160
Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr
165 170 175
Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr
180 185 190
Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Arg Gly
195 200 205
Met Ala Val Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala Asp Gly
210 215 220
Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser
225 230 235 240
Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val Arg Gly Ser
245 250 255
Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn Gly
260 265 270
Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu
275 280 285
Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg
290 295 300
Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln
305 310 315 320
Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly
325 330 335
His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met
340 345 350
Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp Ser Pro
355 360 365
Ser Arg His Val Asp Trp Thr Ala Gly Ser Val Glu Leu Val Thr Glu
370 375 380
Asn Gln Pro Trp Pro Val Leu Glu Arg Ala Arg Arg Val Gly Val Ser
385 390 395 400
Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala
405 410 415
Pro Asp Pro Asp Val Ala Val Val Glu Val Glu Glu Thr Pro Ala Pro
420 425 430
Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu Ala Asp Met
435 440 445
Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Arg Pro Gly Val Asp Val
450 455 460
Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ser Thr Gly
485 490 495
Thr Gly Ser Gly Ala Ala Val Ser Gly Val Ala Val Ser Gly Pro Arg
500 505 510
Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly
515 520 525
Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg Leu Ala Glu
530 535 540
Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val
545 550 555 560
Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu Gln Pro Ala
565 570 575
Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly
580 585 590
Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala
595 600 605
Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala Arg Ile Val
610 615 620
Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln Gly Ala Met
625 630 635 640
Ala Ser Ile Ala Leu Pro Ala His Glu Ile Val Leu Gly Asp Gly Ala
645 650 655
Val Val Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Val Ala Gly Thr
660 665 670
Ala Arg Ala Val Glu Arg Val Leu Ala Val His Glu Lys Glu Gly Ala
675 680 685
Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val
690 695 700
Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr Thr Gly Ser
705 710 715 720
Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Thr
725 730 735
Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro
740 745 750
Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met Gly Glu Thr
755 760 765
Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro Ala Met Asp
770 775 780
Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp Thr Pro Gln
785 790 795 800
Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly Val Asn Ile
805 810 815
His Trp Pro Ala Ile Ile Gly Thr Thr Thr Thr Pro Ala Arg Val Asp
820 825 830
Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp Leu
835 840 845
Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Met Val
850 855 860
Arg Asp Ser Ala Ala Ala Val Leu Gly His Ala Gly Ala Asp Thr Val
865 870 875 880
Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala
885 890 895
Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu Pro
900 905 910
Val Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala Arg
915 920 925
Leu Asp
930
<210> 84
<211> 931
<212> PRT
<213> Streptomyces filamentosus
<400> 84
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Thr Thr Tyr Thr Val Gln Gly Gly
50 55 60
Phe Leu Asp Ile Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Met Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Asn Gly Tyr Gly
115 120 125
Ala Gly Val Asp Phe Gly Ala Phe Gly Gly Ala Ser Ala Ala Val Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Leu Phe Val Asp Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Pro
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn
275 280 285
Ala Arg Leu Ala Pro Asn Glu Ile Asp Ala Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Asp Pro Asp Val Pro Val Val Glu Thr Glu Glu Thr
420 425 430
Pro Pro Pro Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu
435 440 445
Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Thr Pro Gly
450 455 460
Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val
465 470 475 480
Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr
485 490 495
Ser Thr Gly Thr Gly Ser Gly Ala Ala Val Ser Gly Val Val Val Ser
500 505 510
Gly Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
515 520 525
Gly Met Gly Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg
530 535 540
Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu
545 550 555 560
Leu Thr Val Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu
565 570 575
Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln
580 585 590
Glu Ala Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu
595 600 605
Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala
610 615 620
Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln
625 630 635 640
Gly Ala Met Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly
645 650 655
Asp Gly Ala Val Val Ala Ala Arg Asn Gly Arg Ala Ala Thr Val Ile
660 665 670
Ala Gly Thr Ala Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys
675 680 685
Glu Gly Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser
690 695 700
Pro Gln Val Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr
705 710 715 720
Thr Gly Ser Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly
725 730 735
Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu
740 745 750
Arg Glu Pro Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met
755 760 765
Gly Glu Thr Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro
770 775 780
Ala Met Asp Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp
785 790 795 800
Thr Pro Gln Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly
805 810 815
Val Asn Ile His Trp Pro Ala Ile Met Gly Ala Thr Thr Thr Arg Val
820 825 830
Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp
835 840 845
Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val
850 855 860
Val Arg Asp Ser Ala Ala Lys Val Leu Gly His Ala Gly Ala Asp Thr
865 870 875 880
Val Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr
885 890 895
Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu
900 905 910
Pro Ala Thr Met Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala
915 920 925
Arg Leu Asp
930
<210> 85
<211> 910
<212> PRT
<213> Streptomyces filamentosus
<400> 85
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Gly Tyr Arg Val Gln Gly Gly
50 55 60
Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Met
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Leu Gly Ala Phe Gly Met Thr Ser Ala Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp
275 280 285
Asn Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg
385 390 395 400
Val Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro
420 425 430
Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala
435 440 445
Lys Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr
450 455 460
Leu Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu
465 470 475 480
Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp
485 490 495
Asp Thr Val Thr Gly Pro Asp Thr Gly Thr Gly Ala Gly Ser Gly Val
500 505 510
Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser
515 520 525
Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe
530 535 540
Ala Glu Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro
545 550 555 560
Gly Leu Gly Ala Asp Glu Thr Gly Phe Ala Gln Pro Ser Leu Phe Ala
565 570 575
Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro
580 585 590
Gln Ala Val Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val
595 600 605
Ala Gly Leu Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg
610 615 620
Ala Arg Leu Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val
625 630 635 640
Pro Val Ser Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu
645 650 655
Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu
660 665 670
Thr Ala Val Leu Glu Thr Ala Ala Ala Leu Gly Lys Ser Thr Arg Leu
675 680 685
Thr Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp
690 695 700
Gln Phe Arg Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile
705 710 715 720
Pro Met Ala Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg
725 730 735
Gln Ile Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu
740 745 750
Asn Ala Val Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu
755 760 765
Thr Asp Gly Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala
770 775 780
Ile Thr Ala Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp
785 790 795 800
Pro Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr
805 810 815
Tyr Ala Phe Glu Arg Gln Arg Tyr Trp Ala Trp Leu Ala Gly Leu Ala
820 825 830
Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val Val Arg Asp Ser Ala
835 840 845
Ala Ala Val Leu Gly His Ala Asp Ala Arg Asp Ile Ala Val Asn Thr
850 855 860
Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg
865 870 875 880
Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr Thr Thr Val
885 890 895
Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu Asp
900 905 910
<210> 86
<211> 910
<212> PRT
<213> Streptomyces filamentosus
<400> 86
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Ala His Asn Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Thr
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr Gly
115 120 125
Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ser Ser Ala Leu Arg Gln Asp Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Asp Asn
275 280 285
Ala Gly Leu Ser Ser Thr Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg Val
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro Ala
420 425 430
Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Pro Ser Ala Leu Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu
450 455 460
Thr Ser Thr Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Pro Asp Thr Gly Thr Gly Ala Gly Ser Gly Val Ala
500 505 510
Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln
515 520 525
Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala
530 535 540
Glu Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Pro Gly
545 550 555 560
Leu Asp Thr Asp Glu Thr Gly Tyr Ala Gln Pro Ser Leu Phe Ala Leu
565 570 575
Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln
580 585 590
Ala Val Ile Gly His Ser Val Gly Glu Ile Ala Ala Gly Tyr Val Ala
595 600 605
Gly Leu Trp Ser Leu Arg Asp Ala Cys Thr Leu Val Ser Ala Arg Ala
610 615 620
Arg Leu Met Gln Thr Leu Pro Thr Gly Gly Ala Met Val Ala Val Pro
625 630 635 640
Val Ser Glu Lys Gln Ala Gln Ala Ala Leu Thr Asp Gly Val Glu Ile
645 650 655
Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Thr Gly Asp Glu Thr
660 665 670
Ala Val Leu Glu Thr Ala Ala Ala Leu Gly Arg Ser Thr Arg Leu Thr
675 680 685
Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Val Leu Asp Glu
690 695 700
Phe Arg Thr Val Ala Glu Thr Leu Asp Tyr Arg Thr Pro His Ile Pro
705 710 715 720
Met Ala Ala Gly Asp Ala Val Val Thr Pro Glu Tyr Trp Val Arg Gln
725 730 735
Ile Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala His Glu Asn
740 745 750
Ala Val Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu Thr
755 760 765
Asp Gly Ile Ala Met Leu His Gly Asp Asn Glu Thr Gln Thr Ala Ile
770 775 780
Thr Ala Leu Ala Thr Leu His Thr His Gly Val Asn Ile His Trp Pro
785 790 795 800
Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Met Pro Thr Tyr
805 810 815
Ala Phe Gln His Gln Arg Tyr Trp Thr Thr Trp Leu Ala Gly Leu Thr
820 825 830
Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Thr Val Arg Asp Ser Ala
835 840 845
Ala Ala Val Leu Gly His Ala Asp Ala Arg Asp Ile Ala Val Asn Thr
850 855 860
Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Gln Val Arg
865 870 875 880
Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr Thr Thr Val
885 890 895
Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu Asp
900 905 910
<210> 87
<211> 938
<212> PRT
<213> Streptomyces filamentosus
<400> 87
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Cys Val Gln Gly Tyr
50 55 60
Phe Leu Asp Gly Ile Ala Glu Phe Asp Ala Ser Phe Phe Gly Thr Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Gln Ala Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp
275 280 285
Asn Ala Arg Leu Ala Pro Asn Glu Ile Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala
305 310 315 320
Ala Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Pro Pro Ala Gln Pro Val Val Glu Thr Glu Glu Val Pro
420 425 430
Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala
435 440 445
Lys Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr
450 455 460
Leu Ala Ala Arg Pro Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu
465 470 475 480
Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp
485 490 495
Asp Thr Val Thr Gly Thr Ser Thr Gly Thr Gly Ser Gly Ala Ala Val
500 505 510
Ser Gly Val Val Val Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly
515 520 525
Gln Gly Trp Gln Trp Leu Gly Met Gly Cys Gly Leu Arg Glu Thr Ser
530 535 540
Ala Val Phe Ala Gly Arg Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu
545 550 555 560
Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser Val Val
565 570 575
Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser
580 585 590
Leu Ala Ala Val Trp Gln Glu Ala Gly Val Val Pro Asp Ala Val Ile
595 600 605
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu
610 615 620
Thr Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile
625 630 635 640
Ala Arg Leu Ala Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala
645 650 655
His Glu Ile Ala Leu Gly Asp Gly Ala Val Val Ala Ala Arg Asn Gly
660 665 670
Pro Ala Ala Thr Val Ile Ala Gly Thr Pro Arg Ala Val Asp Arg Val
675 680 685
Leu Ala Val His Glu Lys Glu Gly Ala Arg Val Arg Arg Ile Thr Val
690 695 700
Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Thr Glu Leu
705 710 715 720
Leu Asp Ile Leu Ala Thr Thr Gly Ser Arg Thr Pro Val Val Pro Trp
725 730 735
Leu Ser Thr Val Asp Gly Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp
740 745 750
Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val
755 760 765
Asp Thr Leu Arg Ser Met Gly Glu Thr Val Phe Ile Glu Ile Ser Ala
770 775 780
Ser Pro Thr Leu Thr Pro Ala Met Asp Asp Ala Thr Thr Val Ala Thr
785 790 795 800
Leu Arg Arg Asp Asn Asp Thr Pro Arg Gln Ile Leu Thr Ala Leu Ala
805 810 815
Glu Ala His Thr His Gly Val Asn Ile His Trp Pro Thr Val Ile Gly
820 825 830
Thr Thr Thr Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln
835 840 845
His Gln Arg Tyr Trp Thr Ser Trp Leu Ala Gly Leu Ala Pro Ala Glu
850 855 860
Arg Asp Glu Ala Leu Leu Lys Met Val Arg Asp Ser Ala Ala Leu Val
865 870 875 880
Leu Gly His Ala Gly Gly Arg Thr Ile Pro Val Ala Ala Ala Phe Lys
885 890 895
Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu
900 905 910
Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr
915 920 925
Pro Asn Pro Ala Ala Leu Ala Gly Trp Leu
930 935
<210> 88
<211> 931
<212> PRT
<213> Streptomyces filamentosus
<400> 88
Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Ser Pro Gly Glu Gly Glu Ala Tyr Ser Ala Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Gly Ala Met Arg
100 105 110
Gly Ser His Thr Gly Val Phe Met Gly Ala Met Ala Asn Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser
130 135 140
Val Leu Ser Gly Arg Ile Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Thr Thr Gln Thr Phe Val Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala
210 215 220
Ala Asp Gly Ala Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp Asn
275 280 285
Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val
355 360 365
Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Pro Trp Pro Val Thr Glu Arg Ala Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Asp Pro Asp Val Pro Val Val Glu Thr Glu Lys Val
420 425 430
Pro Ala Pro Pro Val Val Val Ile Ser Ala Lys Thr Pro Ser Ala Leu
435 440 445
Val Glu Phe Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Arg Pro Gly
450 455 460
Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser Val
465 470 475 480
Phe Gly His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr
485 490 495
Ser Thr Gly Thr Gly Ser Gly Ala Ala Val Ser Gly Val Val Val Ser
500 505 510
Gly Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
515 520 525
Gly Met Gly Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg
530 535 540
Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu
545 550 555 560
Leu Thr Val Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu
565 570 575
Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln
580 585 590
Glu Ala Gly Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu
595 600 605
Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala
610 615 620
Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln
625 630 635 640
Gly Ala Met Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly
645 650 655
Asp Gly Ala Val Val Ala Ala Leu Asn Gly Pro Ala Ala Thr Val Ile
660 665 670
Ala Gly Thr Pro Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys
675 680 685
Glu Gly Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser
690 695 700
Pro Gln Val Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr
705 710 715 720
Thr Gly Ser Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly
725 730 735
Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu
740 745 750
Arg Glu Pro Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met
755 760 765
Gly Glu Thr Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro
770 775 780
Ala Met Asp Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp
785 790 795 800
Thr Pro Gln Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly
805 810 815
Val Asn Ile His Trp Pro Thr Val Met Gly Ala Thr Thr Thr Arg Val
820 825 830
Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr Ser Trp
835 840 845
Leu Ala Gly Leu Ala Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Val
850 855 860
Val Arg Asp Ser Ala Ala Ala Val Leu Gly His Ala Gly Thr Asp Thr
865 870 875 880
Val Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr
885 890 895
Ala Val Glu Leu Arg Asn Ser Leu Gly Lys Ser Thr Gly Leu Arg Leu
900 905 910
Pro Ala Thr Leu Val Phe Asp Tyr Pro Asn Pro Thr Thr Leu Ala Ala
915 920 925
Arg Leu Asp
930
<210> 89
<211> 929
<212> PRT
<213> Streptomyces filamentosus
<400> 89
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Ile Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Thr Gly Tyr Arg Val Gln Gly Gly
50 55 60
Phe Leu Asp Arg Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Phe Gly Ala Phe Gly Ala Thr Ser Ala Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ser Thr Pro Leu Thr Phe Ala Glu Phe Ala
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Ser Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Val Leu Glu Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Asp Pro Asp Leu Pro Val Val Glu Val Glu Glu
420 425 430
Thr Pro Ala Pro Val Val Ala Val Ile Ser Ala Lys Thr Pro Ser Ala
435 440 445
Leu Val Glu Phe Glu Gly Arg Leu Arg Thr Tyr Leu Thr Ala Arg Pro
450 455 460
Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu Ala Gly Thr Arg Ser
465 470 475 480
Val Phe Gly His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly
485 490 495
Thr Gly Pro Gly Ala Ala Val Ser Gly Val Val Val Ser Gly Pro Arg
500 505 510
Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly
515 520 525
Cys Gly Leu Arg Glu Thr Ser Ala Val Phe Ala Gly Arg Leu Ala Glu
530 535 540
Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val
545 550 555 560
Leu Asp Asp Pro Ser Val Val Asp Arg Val Asp Val Leu Gln Pro Ala
565 570 575
Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Glu Ala Gly
580 585 590
Val Val Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala
595 600 605
Ala Cys Val Ala Gly Ala Leu Thr Leu Arg Asp Ala Ala Arg Ile Val
610 615 620
Ala Leu Arg Ser Arg Leu Ile Ala Arg Leu Ala Gly Gln Gly Ala Met
625 630 635 640
Ala Ser Ile Ala Leu Pro Ala His Glu Ile Ala Leu Gly Asp Gly Ala
645 650 655
Val Val Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly Thr
660 665 670
Pro Arg Ala Val Asp Arg Val Leu Ala Val His Glu Lys Gln Gly Ala
675 680 685
Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Ser Pro Gln Val
690 695 700
Glu Glu Ile Arg Thr Glu Leu Leu Asp Ile Leu Ala Thr Thr Gly Ser
705 710 715 720
Arg Thr Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Thr
725 730 735
Glu Gln Pro Leu Asp Pro Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro
740 745 750
Val Gly Phe His Pro Ala Val Asp Thr Leu Arg Ser Met Gly Glu Thr
755 760 765
Val Phe Ile Glu Ile Ser Ala Ser Pro Thr Leu Thr Pro Ala Met Asp
770 775 780
Asp Ala Thr Thr Val Ala Thr Leu Arg Arg Asp Asn Asp Thr Pro Gln
785 790 795 800
Gln Ile Leu Thr Ala Leu Ala Glu Ala His Thr His Gly Val Asn Ile
805 810 815
His Trp Pro Thr Val Met Gly Ala Thr Thr Thr Pro Val Arg Val Asp
820 825 830
Leu Pro Thr Tyr Ala Phe Glu Arg Gln Arg Tyr Trp Ala Trp Leu Ala
835 840 845
Gly Leu Thr Pro Glu Glu Arg Lys Gln Ala Leu Leu Lys Thr Val Arg
850 855 860
Asp Ser Ala Ala Ala Val Leu Gly His Thr Asp Ala Arg Asp Ile Ala
865 870 875 880
Met Asn Thr Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val
885 890 895
Gln Val Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Thr
900 905 910
Thr Thr Val Phe Asp Tyr Pro Asn Pro Thr Ala Leu Ala Thr His Leu
915 920 925
Asp
<210> 90
<211> 939
<212> PRT
<213> Streptomyces filamentosus
<400> 90
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser His Phe Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Cys Val Gln Gly Tyr
50 55 60
Phe Leu Asp Gly Ile Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Thr Thr Val Leu Ala Thr Pro Tyr Gly Leu Val Glu Ile Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala Phe Ser Asp
210 215 220
Ala Ala Asp Gly Met Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Asp
275 280 285
Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr His Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ala Ile Asp Arg Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Pro Pro Ala Gln Pro Val Val Glu Val Glu Glu Thr Pro
420 425 430
Ala Pro Pro Val Val Ala Ser Asp Met Met Pro Leu Val Ile Ser Ala
435 440 445
Lys Thr Pro Ser Ala Leu Ala Asp Met Glu Gly Arg Leu Arg Ala Tyr
450 455 460
Leu Ala Ala Arg Pro Gly Val Asp Val Arg Ala Val Ala Ser Thr Leu
465 470 475 480
Ala Gly Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp
485 490 495
Asp Thr Val Thr Gly Thr Ser Thr Gly Thr Gly Ser Gly Ala Ala Val
500 505 510
Ser Gly Val Val Val Ser Gly Pro Arg Val Val Phe Val Phe Pro Gly
515 520 525
Gln Gly Trp Gln Trp Leu Gly Met Gly Cys Gly Leu Arg Glu Thr Ser
530 535 540
Ala Val Phe Ala Gly Arg Leu Ala Glu Cys Ala Ala Ala Leu Ser Glu
545 550 555 560
Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro Ser Val Val
565 570 575
Asp Arg Val Asp Val Leu Gln Pro Ala Cys Trp Ala Val Met Val Ser
580 585 590
Leu Ala Ala Val Trp Gln Glu Ala Gly Val Val Pro Asp Ala Val Ile
595 600 605
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu
610 615 620
Thr Leu Arg Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Arg Leu Ile
625 630 635 640
Ala Arg Leu Ala Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala
645 650 655
His Glu Ile Ala Leu Gly Asp Gly Ala Val Val Ala Ala Arg Asn Gly
660 665 670
Arg Ala Ala Thr Val Ile Ala Gly Thr Ala Arg Ala Val Asp Arg Val
675 680 685
Leu Ala Val His Glu Lys Glu Gly Ala Arg Val Arg Arg Ile Ala Val
690 695 700
Asp Tyr Ala Ser His Ser Pro Gln Val Glu Glu Ile Arg Thr Glu Leu
705 710 715 720
Leu Asp Ile Leu Ala Thr Thr Gly Ser Arg Thr Pro Val Val Pro Trp
725 730 735
Leu Ser Thr Val Asp Gly Thr Trp Thr Glu Gln Pro Leu Asp Pro Asp
740 745 750
Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val
755 760 765
Asp Thr Leu Arg Ser Met Gly Glu Thr Val Phe Ile Glu Ile Ser Ala
770 775 780
Ser Pro Thr Leu Thr Pro Ala Met Asp Asp Ala Thr Thr Val Ala Thr
785 790 795 800
Leu Arg Arg Asp Asn Asp Thr Pro Arg Gln Ile Leu Thr Ala Leu Ala
805 810 815
Glu Ala His Thr His Gly Val Asn Ile His Trp Pro Thr Val Ile Gly
820 825 830
Thr Thr Thr Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln
835 840 845
His Gln Arg Tyr Trp Thr Ser Asp Arg Leu Asn Gly Arg Thr Gly Leu
850 855 860
Glu Gln His Arg Val Met Leu Glu Leu Val Leu Gly His Ala Ala Ser
865 870 875 880
Val Leu Gly His Ser Ala Pro Asp Ala Ile Ala Ala Asp Arg Pro Phe
885 890 895
Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn His
900 905 910
Leu Val Ala Glu Thr Gly Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp
915 920 925
His Pro Thr Ala Asp Asp Leu Ala Lys Arg Leu
930 935
<210> 91
<211> 962
<212> PRT
<213> Streptomyces filamentosus
<400> 91
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Gly Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asn Arg Gly Trp Asp Val Ala Asn Leu Tyr
35 40 45
Ser Pro Asp Pro Ala Gly Tyr Thr Ser Tyr Cys Val Gln Gly Gly Phe
50 55 60
Leu Asp Ser Ala Ala Asp Phe Asp Ala Thr Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala
85 90 95
Ser Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Arg Ser Leu Arg
100 105 110
Gly Ser Asn Val Gly Val Phe Val Gly Gly Ala Ser Gln Gly Tyr Gly
115 120 125
Ala Ser Ala Asn Glu Gln Gln Gln Ser Asn Ala Ile Thr Gly Gly Ser
130 135 140
Ser Ser Leu Leu Ser Gly Arg Val Thr Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Ser Gln Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu
180 185 190
Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ser Phe Ser
210 215 220
Ala Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val
225 230 235 240
Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
275 280 285
Ala Asn Ala Gly Leu Thr Ala Ser Gln Val Asp Ala Val Glu Ala His
290 295 300
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Glu Ala Leu Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Ser Thr Pro Ala Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly Val
340 345 350
Ile Lys Met Val Glu Ala Met Arg His Gly Leu Leu Pro Arg Thr Leu
355 360 365
His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Ile
370 375 380
Ala Leu Leu Ser Glu Ser Arg Pro Trp Pro Asp Gly Ser Thr Pro Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val
405 410 415
Val Leu Glu Gln Tyr Arg Asp Pro Ala Gly Pro Asp Thr Pro Thr Gly
420 425 430
Ser Asp Thr Gln Thr Gly Pro Glu Thr Thr Thr Glu His Gly Pro Leu
435 440 445
Pro Leu Met Leu Ser Ala Arg Ser Pro Lys Ala Leu Arg Glu Gln Ala
450 455 460
Gly Arg Leu His Ala Ala Leu Val Glu Ala Pro Arg Trp Arg Pro Leu
465 470 475 480
Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Ser Phe Ala His Arg
485 490 495
Ala Val Ala Val Gly Ser Asp Arg Glu Leu Leu Arg Ala Leu Ser Gln
500 505 510
Leu Ala Asp Gly Gly Thr Ser Pro Ala Leu Val Thr Ala Thr Ala Lys
515 520 525
Ala Gly Arg Val Ala Phe Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu
530 535 540
Gly Met Gly Ser Gly Leu Tyr Glu Arg Phe Pro Ala Phe Ala Arg Thr
545 550 555 560
Trp Asp Leu Val Ser Ala Ala Phe Asp Lys His Leu Asn His Ser Leu
565 570 575
Thr Asp Val Phe Leu Gly Arg Ser Gly Ser Val Thr Ala Glu Leu Val
580 585 590
Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Thr Met Glu Val Ala
595 600 605
Leu Phe Glu Leu Leu Asp Glu Trp Gly Ile Arg Pro Asp Phe Leu Thr
610 615 620
Gly His Ser Ile Gly Glu Ala Ala Ala Ala Tyr Gly Ala Gly Met Leu
625 630 635 640
Ser Leu Glu Asp Val Thr Thr Leu Ile Val Ala Arg Gly Gln Ala Leu
645 650 655
Arg Leu Ser Pro Pro Gly Ala Met Val Ala Leu Arg Ala Ser Glu Glu
660 665 670
Glu Val Arg Glu Phe Leu Asp Arg Thr Gly Ala Ala Leu Asp Leu Ala
675 680 685
Ala Val Asn Ser Pro Thr Ser Val Val Val Ser Gly Ala Pro Asp Ala
690 695 700
Val Ser Asp Phe Arg Thr Ala Trp Thr Glu Ser Gly Arg Glu Ala Arg
705 710 715 720
Ala Leu Asn Val Arg His Ala Phe His Ser Arg His Val Glu Ala Gly
725 730 735
Leu Gly Arg Phe Arg Glu Val Leu Asp Ser Leu Thr Phe Arg Ala Pro
740 745 750
Val Leu Pro Val Val Ser Thr Val Thr Gly Arg Leu Val Glu Pro Ala
755 760 765
Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg Gln Val Arg Gln Thr Val
770 775 780
Arg Phe His Asp Ala Leu Arg Glu Leu Ser Gly Arg Gly Val Gly Thr
785 790 795 800
Phe Val Glu Ile Gly Pro Ser Gly Thr Leu Ala Ser Ala Gly Leu Glu
805 810 815
Cys Leu Gly Gly Asp Ala Ala Phe His Ala Val Gln Arg Pro Arg Ser
820 825 830
Ala Glu Asp Val Cys Leu Met Thr Ala Val Ala Glu Leu His Ala Gly
835 840 845
Gly Thr Ala Val Asp Trp Thr Lys Val Leu Ala Gly Gly Arg Arg Thr
850 855 860
Asp Leu Pro Val Tyr Pro Phe Gln His Glu Ala Tyr Trp Leu Thr Pro
865 870 875 880
Ala Glu Pro Ser Tyr Ala Glu Glu Pro Leu Thr Thr Leu Glu Leu Val
885 890 895
Cys Ser Glu Ala Ala Asn Val Leu Gly Ile Thr Glu Pro Gly Ile Leu
900 905 910
Leu Glu Asp Ser Ser Phe Leu Asp Leu Gly Leu Asp Ser Leu Gly Ala
915 920 925
Met Arg Leu Arg Asn Arg Leu Ser Glu Leu Thr Glu Leu Asp Leu Pro
930 935 940
Ala Thr Leu Leu Phe Asp Asn Pro Asn Pro Thr Asp Leu Ala Ala Tyr
945 950 955 960
Leu Asp
<210> 92
<211> 889
<212> PRT
<213> Micromonospora sp.
<400> 92
Glu Pro Leu Ala Ile Val Gly Met Ala Ala Arg Phe Pro Gly Gly Val
1 5 10 15
Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Val Ser Gly Gly Asp Ala
20 25 30
Ile Gly Gly Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Glu Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Ser Asp Ala Thr Thr Phe Asp Ala Ser Phe Phe Arg Ile Gly
65 70 75 80
Pro Arg Glu Ala Lys Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Arg Pro Glu Thr Leu
100 105 110
Arg Gly Thr Ala Thr Ala Val Phe Ala Gly Ile Ser Leu Gln Asp Tyr
115 120 125
Gly Val Leu Ala Gly Ser Asp Pro Glu Leu Glu Gly Tyr Ala Gly Thr
130 135 140
Gly Asn Ala Pro Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly
145 150 155 160
Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Arg Asp Glu Cys Thr
180 185 190
Leu Ala Val Val Gly Gly Val Thr Val Met Pro Ser Pro Asn Val Phe
195 200 205
Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys
210 215 220
Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn Arg Arg
245 250 255
Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Ser Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Arg
275 280 285
Ala Ala Leu Ala Ala Ala Gly Leu Thr Ala Gly Asp Val Asp Val Val
290 295 300
Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Gly Val Leu Ala Thr Tyr Gly Asp Arg Lys Gly Ala Pro Val Arg Leu
325 330 335
Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val
340 345 350
Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His Gly Val Met Pro
355 360 365
Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala
370 375 380
Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Ser Glu
385 390 395 400
Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn
405 410 415
Ala His Val Ile Leu Glu Gln Ala Phe Pro Ala Thr Glu Pro Glu Pro
420 425 430
Pro Phe Thr Pro Val Val Ser Gly Pro Glu Leu Pro Leu Ile Phe Ser
435 440 445
Ala Lys Asp Pro Asp Ala Leu Ala Ala Gln Thr Arg Val Thr Asp Gly
450 455 460
Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His
465 470 475 480
Arg Thr Val Arg Leu Gly Asp Met Thr Val Thr Gly Ile Ala Val Thr
485 490 495
Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala
500 505 510
Gly Met Gly Arg Asp Leu Met Glu Ala Ser Pro Val Phe Ala Glu Arg
515 520 525
Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Ala
530 535 540
Ala Ile Asp Ala Pro Asp His Val Glu Thr Leu Gln Pro Ala Ser Trp
545 550 555 560
Ala Met Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln
565 570 575
Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
580 585 590
Val Ser Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala Leu
595 600 605
Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser
610 615 620
Ile Pro Leu Pro Ala Asp Ala Ile Glu Leu Thr Gly Glu Val Trp Val
625 630 635 640
Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Val Pro Glu
645 650 655
Ala Val Glu Leu Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val
660 665 670
Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val
675 680 685
Val Ser Val Pro Ser Gln Ala Pro Val Ile Pro Trp Phe Ser Thr Val
690 695 700
Asp Ser Gly Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg
705 710 715 720
Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp
725 730 735
Asn Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala
740 745 750
Leu Glu Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly
755 760 765
Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val
770 775 780
Pro Val Asp Trp Thr Thr Ile Val Ala Pro Ala Pro Phe Val Glu Leu
785 790 795 800
Pro Thr Tyr Pro Phe Gln Gly Glu Arg Tyr Trp Ile Asp Pro Arg Thr
805 810 815
Leu Asp Glu Val Leu Ala Val Val Arg Asp Ser Ala Ala Thr Val Leu
820 825 830
Gly His Thr Asp Pro Thr Ala Ile Thr Pro Asp Arg Ser Phe Lys Asp
835 840 845
Leu Gly Phe Asp Ser Leu Ala Ala Val Gln Leu Arg Asn His Leu Leu
850 855 860
Thr Ala Thr Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro
865 870 875 880
Thr Pro Val Val Leu Ala Gly Glu Val
885
<210> 93
<211> 856
<212> PRT
<213> Micromonospora sp.
<400> 93
Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Ser Glu Gly Arg Asp Ala
20 25 30
Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Glu Pro Gly Asp Ala Ala
35 40 45
Tyr Ala Arg Val Gly Gly Phe Val Thr Gly Ala Thr Gly Phe Asp Ala
50 55 60
Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Gln Ala Met Asp Pro Gln
65 70 75 80
Gln Arg Leu Leu Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly
85 90 95
Ile Ala Pro Asp Glu Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly
100 105 110
Thr Tyr Gly Gln Gly Tyr Gly Glu Leu Ala Val Asp Gly Asp Ala Glu
115 120 125
Gly Tyr Val Gly Ile Gly Asn Ser Gly Ser Val Val Ser Gly Arg Val
130 135 140
Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg
165 170 175
Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser
180 185 190
Ser Pro Leu Ile Phe Gln Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala
195 200 205
Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp
210 215 220
Gly Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Gln
225 230 235 240
Arg Arg Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn
245 250 255
Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln
260 265 270
Gln Arg Val Ile Arg Ala Ala Leu Ala Ser Ala Gly Leu Gly Val Gly
275 280 285
Asp Val Asp Leu Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp
290 295 300
Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Ser Asp Gly Ser
305 310 315 320
Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala
325 330 335
Ala Ala Gly Val Ala Gly Val Ile Lys Ala Val Glu Ala Met Arg His
340 345 350
Gly Val Met Pro Arg Thr Leu His Val Asp Gln Pro Ser Ser His Val
355 360 365
Asp Trp Ser Ala Gly Ala Val Glu Leu Leu Thr Ala Asn Arg Pro Trp
370 375 380
Asp Ser Gly Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile
385 390 395 400
Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Ser Pro Ser Ala Pro
405 410 415
Val Pro Pro Glu Pro Gly Thr Ala Pro Leu Leu Leu Ser Ala Arg Ser
420 425 430
Pro Ala Ala Leu Ala Gln Phe Glu Ser Arg Thr Ala Gly Leu Arg Pro
435 440 445
Ser Arg Asp Leu Ala Ser Thr Leu Ser Arg Arg Ala Leu Phe Asp His
450 455 460
Arg Ala Val Val Leu Pro Asp Gly Asp Thr Val Arg Gly Gly Val Gly
465 470 475 480
Asp Ala Pro Leu Val Phe Val Phe Ala Gly Gln Gly Ser Gln Arg Ala
485 490 495
Asp Met Gly Ser Arg Leu Ala Glu Glu Phe Pro Val Phe Ala Ala Ala
500 505 510
Tyr Glu Arg Val Trp Ser Leu Leu Asp Val Asp Glu Ser Leu Glu Val
515 520 525
Asp His Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Phe Glu Val Ala
530 535 540
Leu Ala Glu Leu Leu Gly Val Arg Pro Asp Ala Val Ile Gly His Ser
545 550 555 560
Val Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Ala Met Ser Leu Glu
565 570 575
Asp Ala Cys Arg Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu
580 585 590
Pro Ser Gly Gly Val Met Val Ser Val Arg Val Ser Glu Glu Ala Ala
595 600 605
Arg Thr Val Leu Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro
610 615 620
Gln Ala Val Val Leu Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala
625 630 635 640
Ala Glu Leu Gly Glu Phe Lys Arg Leu Arg Thr Ser His Ala Phe His
645 650 655
Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Ser
660 665 670
Thr Val Ala Phe Asp Glu Pro Gln Ile Ala Leu Ser Phe Val Pro Ser
675 680 685
Ala Glu Tyr Phe Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu
690 695 700
Gln Val Ala Ala Phe Ala Pro Gly Thr Leu Phe Val Glu Val Gly Pro
705 710 715 720
Asp Gly Ser Leu Ser Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro
725 730 735
Met Lys Ala Leu Ala Tyr Leu Trp Val Arg Gly Val Gly Val Asp Trp
740 745 750
Thr Pro Tyr Ile Gly Asp Gly Arg Leu Asp Asp Ala Pro Thr Tyr Pro
755 760 765
Phe Gln Pro Glu Arg Tyr Trp Pro Glu Gln Arg Arg Arg Ala Arg His
770 775 780
Gly Asp Phe Leu Ala Leu Val Thr Ala Thr Ala Ala Val Val Leu Gly
785 790 795 800
His Pro Glu Gly Thr Asp Ile Pro Ala Asp Thr Pro Phe Gln Ser Leu
805 810 815
Gly Leu Asp Ser Leu Ser Ala Val Asp Leu Arg Asn Gln Leu Ala Gln
820 825 830
Ala Thr Gly Val Arg Leu Ser Pro Thr Ala Val Phe Asp Tyr Pro Thr
835 840 845
Pro Arg Ala Leu Ala Glu Arg Leu
850 855
<210> 94
<211> 899
<212> PRT
<213> Micromonospora sp.
<400> 94
Asp Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val
1 5 10 15
Ala Thr Ala Asp Asp Leu Trp Asp Leu Val Ala Glu Gly Gly Asp Ala
20 25 30
Val Gly Pro Phe Pro Val Asp Arg Gly Trp Asp Leu Ala Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Gly Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ala Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Leu Asp Leu
100 105 110
Arg Arg Ser Asp Thr Gly Val Phe Val Gly Thr Met Ala Gln Glu Tyr
115 120 125
Gly Gly Leu Val Thr Asp Ser Ala His Gly Leu Glu Gly Trp Ile Gly
130 135 140
Thr Gly Asn Ser Gln Ser Val Met Ser Gly Arg Leu Ser Tyr Phe Phe
145 150 155 160
Gly Leu Gln Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser
165 170 175
Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys
180 185 190
Ala Leu Ala Val Val Gly Gly Val Thr Val Met Ser Ser Pro Arg Thr
195 200 205
Phe Gln Glu Phe Ser Arg Gln Arg Gly Met Ala Pro Asp Gly Arg Cys
210 215 220
Lys Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val
225 230 235 240
Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His
245 250 255
Ala Val Leu Ala Val Val Arg Gly Thr Ala Val Asn Gln Asp Gly Thr
260 265 270
Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Gln Val Ile
275 280 285
Arg Ala Ala Leu Glu Arg Ala Gly Leu Gly Val Gly Asp Val Asp Val
290 295 300
Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala
305 310 315 320
Gln Ala Ile Leu Asp Thr Tyr Gly Ser Arg Thr Gly Gly Glu Pro Val
325 330 335
Arg Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala
340 345 350
Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Met Arg His Ala Thr
355 360 365
Met Pro Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp
370 375 380
Ala Ser Gly Ala Val Glu Leu Leu Thr Ala Glu Arg Gly Trp Pro Ala
385 390 395 400
Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly
405 410 415
Thr Asn Ala His Val Ile Val Glu Gly Val Ala Asp Pro Glu Leu Ser
420 425 430
Arg Glu Ala Ser Pro Gly Gly Pro Leu Pro Phe Val Leu Ser Ala Pro
435 440 445
Thr Ala Glu Ala Leu Ser Ala Gln Glu Thr Arg Leu Arg Arg Phe Arg
450 455 460
Val Glu Arg Pro Asp Val Asp Glu Arg Asp Ile Ala Ile Thr Leu Ala
465 470 475 480
Gly Arg Thr Gly Phe Ala His Arg Thr Val Leu Ile Gly Asp Leu Thr
485 490 495
Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val Phe Val Phe Pro
500 505 510
Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp Leu Met Ala Ala
515 520 525
Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala Ala Ala Leu Glu
530 535 540
Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ser Pro Asp Arg Val Glu
545 550 555 560
Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val
565 570 575
Trp Gln Ala Ala Gly Val Gln Pro Ala Ala Val Ile Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Cys Val Ser Gly Ala Ile Ser Leu Gln Asp
595 600 605
Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile Gly Ala Ser Leu
610 615 620
Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala Asp Ala Ile Glu
625 630 635 640
Leu Ile Asp Glu Val Trp Ile Ala Ala Leu Asn Gly Pro Ser Ser Thr
645 650 655
Val Val Ala Gly Ala Pro Glu Ala Val Glu Gln Ile Arg Ala Arg Tyr
660 665 670
Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val
675 680 685
Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser Arg Ala Pro Ala
690 695 700
Ile Pro Trp Phe Ser Thr Val Asp Ser Ala Trp Val Glu Asp Pro Leu
705 710 715 720
Asp Glu Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro Val Gln Phe Gly
725 730 735
Pro Ala Ala Ala Gly Phe Asp Asn Ala Val Phe Ile Glu Val Ser Ala
740 745 750
Arg Pro Val Leu Ile Pro Ala Leu Glu Asp Ala Val Thr Val Pro Thr
755 760 765
Leu Arg Arg Asp Asp Gly Gly Ile Asp Arg Leu His Ala Ser Val Ala
770 775 780
Gln Ala Trp Thr Ala Gly Ala Asp Val Asp Trp Ala Ala Leu Leu Pro
785 790 795 800
Ala Gly Gly Arg Arg Ile Ala Leu Pro Pro Tyr Ala Phe Thr His Glu
805 810 815
Arg Phe Trp Pro Arg Arg Pro Thr Ala Ala Gly Gln Asp Leu Leu Thr
820 825 830
Val Val Arg Thr Ala Ala Ala Thr Val Leu Gly His Arg Asp Ala Ala
835 840 845
Arg Val Pro Ala Asp Arg Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu
850 855 860
Ser Ala Val Gln Leu Arg Asn Glu Leu Leu Thr Ala Thr Gly Val Arg
865 870 875 880
Leu Ser Ala Thr Ala Val Phe Asp His Pro Thr Ala Ala Ala Leu Ala
885 890 895
Glu Ala Leu
<210> 95
<211> 872
<212> PRT
<213> Micromonospora sp.
<400> 95
Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ala Gly Arg Asp Ala
20 25 30
Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Ser Thr Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Met Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Glu Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Tyr Val Gly Thr Tyr Ala Gln Gly Tyr
115 120 125
Gly Glu Leu Ala Ala Ala Thr Ala Gly Glu Gly Phe Val Gly Ile Gly
130 135 140
Asn Ser Gly Ser Val Val Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu
145 150 155 160
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
165 170 175
Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser Met
180 185 190
Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Leu Met Phe Gln
195 200 205
Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala
210 215 220
Phe Ala Glu Ser Ala Asp Gly Thr Gly Trp Gly Glu Gly Val Gly Val
225 230 235 240
Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr Val
245 250 255
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
260 265 270
Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala
275 280 285
Ala Leu Ala Ser Ala Gly Leu Thr Val Gly Asp Val Asp Leu Val Glu
290 295 300
Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala
305 310 315 320
Leu Leu Ala Thr Tyr Gly Ser Ala Gly Ser Pro Val Trp Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly
340 345 350
Val Ile Lys Met Val Gln Ala Met Arg His Gly Val Met Pro Arg Thr
355 360 365
Leu His Val Asp Gln Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala
370 375 380
Val Glu Leu Leu Thr Ala Asn Arg Pro Trp Asp Ser Gly Gly Arg Pro
385 390 395 400
Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
405 410 415
Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Asp Ala
420 425 430
Glu Thr Ala Pro Leu Val Leu Ser Ala Arg Thr Ala Pro Ala Leu Thr
435 440 445
Asp Leu Glu Ala Arg Val Ser Ala Arg Pro Ser Ser Pro Asp Leu Ala
450 455 460
Ala Thr Leu Ala Gly Arg Ala Ser Phe Asp His Arg Ala Val Val Leu
465 470 475 480
Pro Asp Gly Glu Val Val Arg Gly Arg Ala Gly Ala Ala Pro Val Val
485 490 495
Leu Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg
500 505 510
Leu Ala Gly Glu Phe Pro Val Phe Ala Ala Ala Tyr Glu Arg Val Trp
515 520 525
Ser Leu Leu Asp Val Asp Glu Ala Leu Asp Thr Asp Gln Thr Gly Phe
530 535 540
Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu
545 550 555 560
Asn Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala
565 570 575
Ala Ala Tyr Thr Ser Gly Ser Leu Ser Leu Glu Asp Ala Cys Arg Leu
580 585 590
Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Ala
595 600 605
Met Val Ser Val Arg Val Ser Glu Glu Val Ala Arg Glu Val Leu Arg
610 615 620
Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Val Val Leu
625 630 635 640
Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Lys Leu Gly Glu
645 650 655
Phe Lys Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met Glu
660 665 670
Pro Met Leu Glu Glu Phe Arg Ala Val Ala Leu Thr Val Glu Phe Arg
675 680 685
Glu Pro Glu Val Ala Leu Ser Phe Val Pro Ser Ala Glu Tyr Phe Val
690 695 700
Gly Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe
705 710 715 720
Glu Pro Gly Thr Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser
725 730 735
Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu Ala
740 745 750
Tyr Leu Trp Val His Gly Val Ala Ile Asp Trp Val Pro Tyr Leu Gly
755 760 765
Gly Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln His Glu
770 775 780
Arg Tyr Trp Pro Ala Arg Ala Leu Ala Gln Leu Pro Pro Ala Arg Arg
785 790 795 800
Gly Arg Ala Leu Leu Asp Leu Val Gln Asn Arg Val Ala Lys Thr Leu
805 810 815
Gly Leu Val Arg Pro Ala Asp Pro Gly Arg Ala Phe Thr Asp Leu Gly
820 825 830
Phe Thr Ser Leu Thr Ala Leu Glu Leu Arg Asn Ser Ile Ala Glu Glu
835 840 845
Thr Gly Leu Pro Met Pro Ala Ser Leu Val Phe Asp His Pro Asn Ala
850 855 860
Arg Ser Leu Ala Gly Tyr Leu Asp
865 870
<210> 96
<211> 896
<212> PRT
<213> Micromonospora sp.
<400> 96
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Ala Glu Glu Leu Trp Arg Leu Val Ala Glu Gly Gly Asp Ala
20 25 30
Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Asp Val Asp Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Ala Gly His Thr Tyr Thr Arg Ser Gly Gly Phe
50 55 60
Leu Pro Gly Ala Thr Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Gln Ala Met Asp Pro Gln His Arg Gln Leu Leu Glu Thr
85 90 95
Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro Ala Gly Leu Arg
100 105 110
Gly Arg Asp Val Gly Val Phe Ala Gly Phe Ser Gly Gln Asp Tyr Ile
115 120 125
Ala Glu Met Gly Val Gly Pro Ala Glu Ala Gly Gly Tyr Gln Val Thr
130 135 140
Gly Arg Ala Ala Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly
145 150 155 160
Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Asp Gly Glu Ser Ser
180 185 190
Leu Ala Leu Val Gly Gly Val Thr Val Met Ser Ser Pro Gly Leu Phe
195 200 205
Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys
210 215 220
Ala Phe Ser Ala Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Arg
245 250 255
Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg
275 280 285
Gln Ala Leu Ala Gln Ser Gly Leu Ser Val Ala Asp Val Asp Val Val
290 295 300
Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Ala Val Leu Ala Thr Tyr Gly Gly Arg Ala Gly Gly Glu Pro Val Arg
325 330 335
Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly
340 345 350
Ile Ala Ser Leu Ile Lys Met Val Gln Ala Ile Arg Tyr Gly Val Met
355 360 365
Pro Arg Thr Leu His Val Ser Glu Pro Ser Pro Leu Val Asp Trp Ala
370 375 380
Ser Gly Arg Val Glu Leu Leu Thr Ser Asp Ile Pro Trp Pro Asp Gly
385 390 395 400
Val Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala
405 410 415
His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro Ser Ile
420 425 430
Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg
435 440 445
Asp Pro Ser Ala Leu Ala Ala Gln Thr Arg Val Thr Asp Gly Pro Gly
450 455 460
Val Ala Tyr Ala Leu Ala Thr Ser Arg Thr Met Leu Asp His Arg Thr
465 470 475 480
Val Arg Leu Asn Asp Val Thr Val Thr Gly Ile Ala Val Thr Asp Pro
485 490 495
Glu Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Ala Gly Met
500 505 510
Gly Arg Asp Leu Met Gly Ser Ser Pro Val Phe Ala Glu Arg Met Asn
515 520 525
Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Ala Ala Ile
530 535 540
Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val
545 550 555 560
Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln Pro Ala
565 570 575
Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ser
580 585 590
Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala Leu Arg Ser
595 600 605
Arg Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser Ile Pro
610 615 620
Leu Pro Ala Asp Ala Ile Glu Leu Ala Asp Glu Val Trp Val Ala Ala
625 630 635 640
Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Leu Glu Ala Val
645 650 655
Glu Gln Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val Asp Tyr
660 665 670
Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser
675 680 685
Val Pro Ser Gln Ala Pro Ala Ile Pro Trp Phe Ser Thr Val Asp Ser
690 695 700
Gly Trp Ile Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg Asn Leu
705 710 715 720
Arg Gln Gln Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp Asn Ala
725 730 735
Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Asp
740 745 750
Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Pro Glu
755 760 765
Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Pro Val
770 775 780
Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Glu Leu Pro Ser
785 790 795 800
Tyr Pro Phe Gln Arg Gln Arg His Trp Ile Asp Met Glu Arg Leu Gly
805 810 815
Gln Leu Pro Pro Gly Asp Arg Asp Arg Phe Leu Leu Asp Leu Val Arg
820 825 830
Asp Ala Ala Ala Ala Val Leu Gly His Gly Ser Arg Glu Thr Val Pro
835 840 845
Ala Ser Ala Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu Ile Ala Val
850 855 860
Gln Leu Arg Asn Ala Val Ser Ala Ala Thr Gly Val Arg Leu Pro Ala
865 870 875 880
Thr Val Thr Phe Asp His Pro Thr Pro Gln Ala Leu Ala Ala Leu Leu
885 890 895
<210> 97
<211> 919
<212> PRT
<213> Micromonospora sp.
<400> 97
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Lys Phe Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Arg Leu Trp Glu Met Leu Glu Ala Gly Glu Asp Val
20 25 30
Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Gly Gly Tyr
35 40 45
Asp Pro Asp Pro Glu Lys Ala Gly Ser Trp Tyr Ala Arg Ala Gly Gly
50 55 60
Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Asn
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ser Gly Ile Ala Pro Asp Ser Leu
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Val Gly Thr Phe Gly Gln Gly Tyr
115 120 125
Gly Arg Leu Val Ser Ala Gly Ala Pro Gly Leu Glu Ala Tyr Ser Gly
130 135 140
Thr Gly Asn Thr Gly Ser Val Ala Ser Gly Arg Leu Ser Tyr Val Phe
145 150 155 160
Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser
165 170 175
Leu Val Ala Leu His Gln Ala Ser Gln Ser Leu His Arg Gly Glu Cys
180 185 190
Ser Leu Ala Leu Val Ala Gly Val Thr Val Met Ser Thr Pro Asp Ser
195 200 205
Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys
210 215 220
Lys Ala Phe Ala Ala Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala
225 230 235 240
Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His
245 250 255
Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala
260 265 270
Ser Asn Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile
275 280 285
Asn Thr Ala Leu Thr Asp Ala Asp Leu Thr Thr Thr Asp Ile Asp Leu
290 295 300
Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala
305 310 315 320
Gln Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val
325 330 335
His Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala
340 345 350
Gly Val Ala Gly Val Ile Lys Val Ile Gln Ala Met Arg His Ala Thr
355 360 365
Met Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp
370 375 380
Thr Ala Gly Arg Val Glu Leu Leu Thr Gly Asn Arg Pro Trp Pro Ala
385 390 395 400
Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly
405 410 415
Thr Asn Ala His Val Ile Leu Glu Glu Arg Ala Ala Ala Glu Glu Gln
420 425 430
Pro Pro Ala Val Asp Gly Pro Val Pro Leu Val Leu Ser Ala Arg Thr
435 440 445
Pro Glu Ala Leu Thr Ala Gln Glu Glu Ala Val Arg Gly Leu Ser Thr
450 455 460
Asp Asp Arg His Arg Val Ala Pro Ala Leu Ala Leu Gly Arg Ala Ala
465 470 475 480
Leu Pro His Arg Ala Val Leu Leu Gly Asp Ser Val Ile Arg Gly Thr
485 490 495
Ala Ser Ala Asp Asp Gly Arg Pro Val Phe Leu Phe Pro Gly Gln Gly
500 505 510
Ala Gln Trp Ala Gly Met Gly Arg Glu Leu Met Ala Ala Ser Pro Val
515 520 525
Phe Ala Glu Arg Met Arg Glu Cys Ala Val Ala Leu Ala Gly Phe Val
530 535 540
Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Ala Glu Ala Leu Arg Arg
545 550 555 560
Thr Glu Ile Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala
565 570 575
Ala Leu Trp Glu Ser Trp Gly Val His Pro Ala Ala Val Val Gly His
580 585 590
Ser Gln Gly Glu Thr Ala Ala Ala Val Val Ala Gly Ala Ile Gly Leu
595 600 605
Arg Asp Gly Ala Arg Leu Ser Ala Thr Arg Ser Arg Val Leu Ala Leu
610 615 620
Leu Ala Gly His Gly Ala Leu Ala Ser Ile Ala Leu Pro Ala Ala Glu
625 630 635 640
Val Glu Val Val Asp Gly Val Ser Val Ala Ala Val Asn Gly Pro Arg
645 650 655
Ala Thr Leu Ile Ser Gly Asp Pro Ala Gly Val Glu Ala Val Thr Ala
660 665 670
Arg Tyr Glu Ala Ser Gly Val Arg Val Arg Arg Ile Pro Ala Asp Val
675 680 685
Ala Ser His Ser Pro His Val Glu Arg Ala Glu Glu Thr Leu Leu Thr
690 695 700
Ala Leu Ala Gly Ile Glu Ala Arg Val Pro Gly Val Pro Trp Leu Ser
705 710 715 720
Thr Ala Thr Gly Asp Trp Ile Thr Glu Pro Val Asp Glu Arg Tyr Trp
725 730 735
Tyr Arg Asn Leu Arg Ser Pro Val Leu Phe His Pro Ala Ile Thr Thr
740 745 750
Leu Arg Asp Arg Gly His Arg Leu Phe Leu Glu Ile Ser Thr His Pro
755 760 765
Gln Leu Leu Pro Ala Met Glu Asp Asp Leu Leu Thr Val Gly Ser Leu
770 775 780
Arg Arg Asp Asp Gly Gly Pro Asp Arg Met His Thr Ala Leu Ala Glu
785 790 795 800
Ala Trp Ala Gly Gly Ala Asp Val Asp Trp Pro Ala Val Leu Gly Ala
805 810 815
Gly Pro Val Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Arg
820 825 830
Arg Phe Trp Pro Glu Ala Ala Leu Pro Pro Val Glu Arg Asp Arg Ala
835 840 845
Leu Val Glu Ile Val Arg Asp Gln Ala Ala Ala Val Leu Gly His Pro
850 855 860
Asp Ala Gly Ala Leu Thr Pro Gly Thr Ala Phe Arg Asp Leu Gly Phe
865 870 875 880
Asp Ser Leu Thr Ala Val Gln Leu Arg Asn His Leu Ala Thr Ala Thr
885 890 895
Gly Leu Thr Leu Pro Ala Thr Val Ile Phe Asp His Pro Thr Pro Arg
900 905 910
Ala Leu Ala Thr Phe Leu Asp
915
<210> 98
<211> 883
<212> PRT
<213> Micromonospora sp.
<400> 98
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ala Ser Pro Asp Gln Leu Trp Asp Leu Val Val Ser Gly Gly Asp Gly
20 25 30
Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Pro Thr Asp Asp Ile Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Asp Gly Ala Gly Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Ala Gly Leu
100 105 110
Arg Gly Gly Asp Thr Gly Val Phe Val Gly Gly Phe Thr Gln Ala Tyr
115 120 125
Gly Val Gly Thr Ala Asp Leu Glu Gly Tyr Ala Ala Thr Gly Thr Val
130 135 140
Gly Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly
145 150 155 160
Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Gln Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Thr Leu Ala Val
180 185 190
Val Gly Gly Val Thr Val Met Pro Thr Pro Val Val Phe Gln Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Cys Lys Ala Phe Ala
210 215 220
Asp Glu Ala Asp Gly Thr Gly Phe Ala Glu Gly Ala Gly Val Leu Leu
225 230 235 240
Val Cys Arg Leu Ser Asp Ala Arg Arg Asp Gly Arg Arg Ile Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu
275 280 285
Ala Asn Ala Arg Leu Gly Pro Gly Asp Val Asp Leu Ile Glu Gly His
290 295 300
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu
305 310 315 320
Ala Thr His Gly Ser Gly Ala Ser Pro Val Arg Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile
340 345 350
Lys Val Ile Gln Ala Leu Arg Asn Gly Leu Met Pro Arg Thr Leu His
355 360 365
Ala Gly Thr Pro Ser Ser Arg Val Asp Trp Ser Ala Gly Asn Val Glu
370 375 380
Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Ala Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Glu Ala Pro Ala Ala Ala Ala Val Pro Thr Ile Ser Pro Val
420 425 430
Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg Asp Pro Ser
435 440 445
Ala Leu Ala Ala Gln Thr Arg Val Thr Glu Gly Pro Gly Val Ala Phe
450 455 460
Ala Leu Ala Thr Thr Arg Ser Met Phe Glu His Arg Ala Val Arg Ile
465 470 475 480
Gly Asp Phe Ser Val Ser Gly Ala Ala Val Ala Asp Arg Arg Val Val
485 490 495
Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp
500 505 510
Leu Met Ser Ala Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala
515 520 525
Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ser Pro
530 535 540
Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser
545 550 555 560
Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln Pro Ala Ala Val Ile
565 570 575
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Ile
580 585 590
Thr Leu Gln Asp Ala Ala Ala Val Val Ala Leu Arg Ser Arg Ala Ile
595 600 605
Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala
610 615 620
Glu Gln Ile Glu Leu Ala Gly Glu Val Trp Val Ala Ala Leu Asn Gly
625 630 635 640
Pro Ser Ser Thr Val Val Ala Gly Leu Pro Glu Ala Val Glu Gln Val
645 650 655
Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His
660 665 670
Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser
675 680 685
Arg Ala Pro Ala Ile Pro Trp Phe Ser Thr Val Asp Ser Gly Trp Ile
690 695 700
Glu Gly Pro Leu Asp Glu Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro
705 710 715 720
Val Gln Phe Gly Pro Ala Ala Gly Arg Phe Asp Asp Ala Val Phe Ile
725 730 735
Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Glu Asp Ala Ala
740 745 750
Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Gly Asp Arg Met Leu
755 760 765
Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Pro Val Asp Trp Thr
770 775 780
Thr Ile Ile Pro Pro Ala Pro Phe Val Glu Leu Pro Ser Tyr Pro Phe
785 790 795 800
Gln His Arg Arg Tyr Trp Ile Asp Ser Ser Glu Asp Ala Leu Arg Asp
805 810 815
Leu Val Arg Glu Gln Ala Ala Ala Val Leu Gly Tyr Pro Asp Pro Ser
820 825 830
Arg Ile Thr Pro Gly Val Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu
835 840 845
Thr Ala Val Gln Leu Arg Asn Ala Leu Ser Ala Ala Thr Gly Leu Arg
850 855 860
Leu Ser Ala Thr Val Ala Phe Asp His Pro Thr Pro Ala Ala Leu Ala
865 870 875 880
Ala Ala Leu
<210> 99
<211> 874
<212> PRT
<213> Micromonospora sp.
<400> 99
Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ser Gly Arg Asp Ala
20 25 30
Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Asp Glu Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Thr Gly Ala Ala Asp Phe Asp Ala Gly Phe Phe Gly Ile Asn
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ser Leu
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Leu Gly Ala Phe Ala Gly Gly Tyr
115 120 125
Leu Thr Leu Val Asn Gly Ala Ala Asp Leu Glu Gly Tyr Ala Gly Thr
130 135 140
Gly Asn Ser Val Ser Val Leu Ser Gly Arg Leu Ser Tyr Val Leu Gly
145 150 155 160
Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser
180 185 190
Leu Ala Val Val Gly Gly Val Thr Val Met Ser Thr Pro Asp Ser His
195 200 205
Val Glu Phe Ser Arg Gln Arg Ala Leu Ser Pro Asp Gly Arg Cys Lys
210 215 220
Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr
245 250 255
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg
275 280 285
Ala Ala Leu Ala Ser Ala Gly Leu Gly Val Gly Asp Val Asp Leu Val
290 295 300
Glu Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Ala Leu Leu Ala Thr Tyr Gly Ser Asp Gly Ser Pro Val Trp Leu Gly
325 330 335
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
340 345 350
Gly Val Ile Lys Ala Val Glu Ser Met Arg Arg Gly Val Met Pro Gln
355 360 365
Thr Leu His Val Gly Thr Pro Ser Ser His Val Asp Trp Ala Ala Gly
370 375 380
Ala Val Glu Leu Leu Thr Ala Asn Arg Ala Trp Asp Ser Val Glu Arg
385 390 395 400
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala
405 410 415
His Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Ser
420 425 430
Ala Glu Ser Ala Pro Leu Leu Leu Ser Ala Arg Ser Ala Ala Ala Leu
435 440 445
Ala Gln Phe Glu Ser Leu Thr Ser Gly Leu Arg Pro Ser Arg Asp Leu
450 455 460
Ala Ser Thr Leu Ser Arg Arg Ala Phe Phe Asp His Arg Ala Val Val
465 470 475 480
Leu Pro Gly Gly Asp Val Val Arg Gly Arg Val Gly Asp Ala Pro Val
485 490 495
Val Leu Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser
500 505 510
Arg Leu Thr Ala Glu Phe Pro Val Phe Ala Ala Ala His Glu Arg Val
515 520 525
Trp Ser Leu Leu Asp Val Asp Glu Gly Leu Gly Ile Asp Gln Thr Gly
530 535 540
Phe Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu
545 550 555 560
Leu Asp Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu
565 570 575
Ala Ala Ala Tyr Val Ala Gly Ala Val Ser Leu Glu Asp Ala Cys Arg
580 585 590
Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly
595 600 605
Ala Met Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu
610 615 620
Arg Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Val Val
625 630 635 640
Leu Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly
645 650 655
Glu Phe Lys Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met
660 665 670
Glu Pro Met Leu Asp Glu Phe Arg Ala Val Ala Leu Thr Val Glu Phe
675 680 685
Arg Glu Pro Glu Val Ala Leu Ser Phe Val Pro Ser Ala Glu Tyr Phe
690 695 700
Val Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ala
705 710 715 720
Phe Ala Pro Gly Thr Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu
725 730 735
Ser Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu
740 745 750
Ala Tyr Leu Trp Val Arg Gly Val Gly Val Glu Trp Thr Pro Tyr Val
755 760 765
Gly Gly Gly Ile Leu Asp Gln Gly Ala Pro Thr Tyr Pro Phe Gln Arg
770 775 780
Glu Arg Tyr Trp Val Arg Pro Arg Leu Ala Gly Arg Thr Thr Asp Glu
785 790 795 800
Arg Asp Ala Leu Leu Ile Asp Leu Val Arg Asp Asp Val Ala Ser Val
805 810 815
Leu Gly His Ser Gly Arg Arg Arg Leu Glu Thr Asp Arg Pro Leu Leu
820 825 830
Glu Leu Gly Phe Asp Ser Leu Thr Ala Leu Arg Leu Arg Asn Arg Leu
835 840 845
Ala Ala Ala Thr Asp Val Ala Leu Pro Ala Thr Leu Ile Phe Asp Tyr
850 855 860
Pro Asn Ile Gln Ala Ile Ala Val His Leu
865 870
<210> 100
<211> 898
<212> PRT
<213> Micromonospora sp.
<400> 100
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val
1 5 10 15
Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Ala Ala Gly Gly Asp Ala
20 25 30
Val Gly Pro Phe Pro Asp Asp Arg Gly Trp Glu Leu Glu Ser Leu Val
35 40 45
Asp Pro Asp Pro Glu Ala Val Gly Arg Ser Thr Thr Gly Gln Gly Gly
50 55 60
Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Ala Ala Leu Glu His Ala Gly Leu Arg Ala Asp Ala Leu
100 105 110
Arg Gly Ser Ala Thr Gly Val Phe Met Gly Ser Asn Gly Gln Asp Tyr
115 120 125
Ala Gly Leu Leu Ala Gly Ala Pro Glu Leu Glu Gly Trp Ile Gly Thr
130 135 140
Gly Val Ser Ala Ser Val Val Ser Gly Arg Leu Ser Tyr Phe Tyr Gly
145 150 155 160
Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Leu Ala Ala Gln Ser Leu Arg Thr Gly Glu Ser Ser
180 185 190
Leu Ala Leu Val Gly Gly Val Thr Val Met Thr Ser Pro Thr Val Phe
195 200 205
Arg Ser Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys
210 215 220
Ala Phe Ser Ala Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Asp Ala Gln Arg Asn Gly His Gln
245 250 255
Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Asn Gly Leu Thr Ala Pro His Gly Pro Ser Gln Gln Arg Val Ile Asn
275 280 285
Thr Ala Leu Thr Asp Ala Asp Leu Thr Thr Thr Asp Ile Asp Leu Ile
290 295 300
Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val His
325 330 335
Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly
340 345 350
Ile Ala Gly Ile Ile Lys Ala Ile Gln Ala Met Arg His Ala Thr Met
355 360 365
Pro Arg Thr Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr
370 375 380
Ala Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Thr
385 390 395 400
Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr
405 410 415
Asn Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro
420 425 430
Ser Ile Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser
435 440 445
Ala Lys Asp Pro Asp Ala Leu Ala Glu Phe Gln Ser His Thr Pro Ala
450 455 460
Gly Glu Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Thr Leu Asp
465 470 475 480
His Arg Ser Val Arg Ile Gly Asp Val Thr Val Thr Gly Ile Ala Val
485 490 495
Thr Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp
500 505 510
Ala Gly Met Gly Arg Asp Leu Met Ser Ala Ser Pro Val Phe Ala Glu
515 520 525
Arg Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp
530 535 540
Ala Ala Ile Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser
545 550 555 560
Trp Ala Met Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val
565 570 575
Gln Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala
580 585 590
Cys Val Ser Gly Ala Ile Ser Leu Gln Asp Ala Ala Ala Val Val Ala
595 600 605
Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala
610 615 620
Ser Ile Pro Leu Pro Ala Asp Ala Ile Glu Leu Thr Gly Glu Val Trp
625 630 635 640
Val Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Val Pro
645 650 655
Glu Ala Val Glu Leu Val Arg Ala Arg Tyr Glu Gly Arg Arg Ile Ala
660 665 670
Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln
675 680 685
Val Val Ser Val Pro Ser Gln Ala Pro Val Ile Pro Trp Phe Ser Thr
690 695 700
Val Asp Ser Gly Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe
705 710 715 720
Arg Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe
725 730 735
Asp Asn Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro
740 745 750
Ala Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly
755 760 765
Gly Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly
770 775 780
Val Pro Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Asp
785 790 795 800
Leu Pro Ser Tyr Pro Phe Gln His Gln Arg Phe Trp Ile Glu Gly Arg
805 810 815
Val Thr Ala Ala Ala Gly Ala Glu Arg Leu Arg Ile Met Leu Glu Val
820 825 830
Val Leu Ala Glu Thr Ala Thr Val Leu Gly His Gly Gly Ala Ala Ala
835 840 845
Ile Gly Pro Gly Arg Ala Phe Gln Asp Leu Gly Phe Asp Ser Leu Thr
850 855 860
Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu
865 870 875 880
Pro Thr Thr Leu Val Phe Asn His Pro Thr Pro Glu Ala Leu Ala Ala
885 890 895
His Leu
<210> 101
<211> 947
<212> PRT
<213> Micromonospora sp.
<400> 101
Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Glu Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala
20 25 30
Val Gly Pro Phe Pro Ser Asp Arg Gly Trp Asn Leu Gly Thr Leu Asp
35 40 45
Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Lys Glu Gly Gly Phe Leu
50 55 60
Ala Gly Ala Ala His Phe Asp Pro Ala Phe Phe Gly Ile Gly Pro Arg
65 70 75 80
Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala
85 90 95
Trp Glu Ala Leu Glu His Ala Arg Ile Ala Pro Gly Asp Leu Arg Gly
100 105 110
Ser Glu Thr Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Val
115 120 125
Asp Ala Pro Leu Glu Gly Asn Leu Leu Thr Gly Gly Ser Thr Ser Ala
130 135 140
Met Ser Gly Arg Val Ala Tyr Ala Leu Gly Leu His Gly Pro Ala Val
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala
165 170 175
Ala Gln Ala Leu Arg His Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly
180 185 190
Val Ala Val Met Ala Ser Pro Val Leu Phe Thr Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Ala Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val Val Leu Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Arg His Gly His Arg Val Leu Ala Val Ile Arg
245 250 255
Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Thr Ala Gln Arg Arg Val Ile Arg Ser Ala Leu Arg Ala Ala
275 280 285
Gly Leu Gly Ala Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Ile Ala Thr Tyr
305 310 315 320
Gly Gln Arg Ser Asp Thr Pro Pro Val Arg Ile Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Val Ala Ala Ala Gly Val Ala Gly Val Ile Lys
340 345 350
Met Val Glu Ala Met Arg His Gly Thr Met Pro Arg Thr Leu His Val
355 360 365
Asp Arg Pro Thr Pro His Val Asp Trp Ser Ala Gly Ala Ala Glu Leu
370 375 380
Leu Thr Gly Glu Leu Pro Trp Pro Arg Gly Asp Arg Pro Arg Arg Ala
385 390 395 400
Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Leu Ile Leu
405 410 415
Glu Asp Val Ala Ala Ala Ala Glu Pro Pro Ala Gly Asp Asp Ser Gly
420 425 430
Ser Gly Ser Glu Thr Val Pro Leu Leu Leu Ser Ala Asp Asp Leu Pro
435 440 445
Ala Val Arg Asp Gln Ala Ala Arg Leu Arg Ala His Leu Leu Ala His
450 455 460
Pro Glu Leu Arg Met Arg Asp Val Ala Tyr Ala Leu Ala Thr Thr Arg
465 470 475 480
Thr Ala Arg Pro His Arg Ala Ala Val Thr Ala Thr Glu Arg Glu Leu
485 490 495
Leu Arg Glu Leu Ala Leu Leu Ala Ala Gly Asp Gln Gly Pro Gly Thr
500 505 510
Gln Leu Gly Glu Ala Val Pro His Arg Arg Val Ala Phe Leu Phe Asp
515 520 525
Gly Gln Gly Thr Gln Arg His Gly Met Gly Arg Ala Leu His Gln Arg
530 535 540
His Pro Val Phe Ala Ala Ala Trp Asp Glu Val Cys Ala Ala Leu Asp
545 550 555 560
Pro Leu Leu Asp Arg Gly Val Ala Glu Val Tyr Phe Ala Glu Ala Gly
565 570 575
Arg Asp Leu Ala Asp Asp Pro Leu Tyr Thr Gln Ala Gly Leu Phe Ala
580 585 590
Leu Glu Val Ala Leu Tyr Arg Leu Leu Thr Ser Trp Gly Val Thr Pro
595 600 605
Asp Ala Val Ala Gly His Ser Val Gly Glu Val Ala Val Ala His Val
610 615 620
Ala Gly Val Leu Ser Leu Pro Asp Ala Ala Ser Leu Leu Ala Ala Arg
625 630 635 640
Gly Ala Ala Leu Arg Gln Leu Pro Pro Gly Ala Met Ala Ala Ile Arg
645 650 655
Ala Ser Glu Asp Asp Thr Arg Gly Val Leu Pro Pro Asp Leu Asp Val
660 665 670
Ala Ala Val Asn Gly Pro Glu Met Thr Val Val Ser Gly Ala Glu Glu
675 680 685
Ala Val Asp Arg Phe Val Ala Glu Gln Ala Gly Ala Gly Arg Gln Val
690 695 700
Arg Arg Leu Arg Val Gly Arg Ala Tyr His Ser Arg His Val Asp Ala
705 710 715 720
Val Leu Ala Glu Phe Gly Ala Thr Leu Ser Ala Leu Thr Phe His Glu
725 730 735
Pro Thr Leu Pro Val Val Ser Thr Val Thr Gly Arg Pro Ala Gly Ala
740 745 750
Gly Asp Leu Thr Thr Pro Glu Tyr Trp Leu Arg His Ala Arg Arg Pro
755 760 765
Val Arg Phe Gly Ala Ala Leu Ala Ser Leu Ser Glu Leu Gly Met Asp
770 775 780
Ser Phe Val Glu Val Gly Pro Ser Gly Ser Leu Ser Ser Met Ala Gly
785 790 795 800
Glu Thr Val Ala Gly Thr Phe His Pro Leu Leu Asp Arg Arg Val Pro
805 810 815
Asp Glu Ile Gly Ala Ala Ala Ala Ala Gly Glu Leu Phe Thr Ala Gly
820 825 830
Met Ala Leu Asp Trp Thr Ala Val Leu Ala Gly Gly Arg Pro Ile Asp
835 840 845
Leu Pro Val Tyr Pro Phe Arg Arg Glu Phe Tyr Trp Leu Gly Ala Arg
850 855 860
Tyr Asp Leu Met Ala Ala Ala Val Arg Arg Asp Ala Leu Leu Asp Leu
865 870 875 880
Val Arg Val Gln Val Ala Leu Leu Leu Gly Arg Ala Asp Ala Ile Gly
885 890 895
Val Arg Asp Asn Thr Ser Phe Leu Asp Val Gly Leu Asp Ser Leu Gly
900 905 910
Ala Ser Arg Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu
915 920 925
Pro Gly Gly Leu Ala Phe Asp His Pro Thr Pro Ala Arg Leu Ala Asp
930 935 940
His Leu Asp
945
<210> 102
<211> 913
<212> PRT
<213> Catellatospora ferruginea
<400> 102
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Trp Ser Pro Glu Asp Leu Trp His Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Lys Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Glu Ala Thr Ala Ala Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Gly Gly
130 135 140
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
145 150 155 160
Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Gln Ala Ala Tyr Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala
180 185 190
Leu Val Gly Gly Val Thr Val Met Gly Thr Pro His Met Phe Val Asp
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe
210 215 220
Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu
245 250 255
Ala Val Val Lys Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Asn Ala Asp Leu Ala Pro His Glu Val Asp Val Val Glu Ala
290 295 300
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu
305 310 315 320
Leu Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser
325 330 335
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
340 345 350
Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr
355 360 365
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
370 375 380
Val Glu Leu Val Thr Gln Asn Gln Pro Trp Pro Ser Ser Asp Arg Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
405 410 415
Ile Ile Leu Glu Ser Ala Pro Ala Gln Pro Leu Ala Pro Ser Thr Pro
420 425 430
Ile Thr Gly Leu Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala
435 440 445
Leu Thr Ala Phe Glu Ala Arg Leu Arg Ser Tyr Val Thr Ala Asp Ala
450 455 460
Asp Leu Thr Ala Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe
465 470 475 480
Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala
485 490 495
Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln
500 505 510
Trp Leu Gly Met Gly Ser Ala Leu Arg Glu Thr Ser Val Val Phe Lys
515 520 525
Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp
530 535 540
Asp Leu Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp
545 550 555 560
Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr
565 570 575
Trp Gln Ala Ala Gly Ala Arg Pro Asp Ala Val Val Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Gln Asp
595 600 605
Gly Ala Arg Val Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala
610 615 620
Gly His Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr
625 630 635 640
Leu Thr Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr
645 650 655
Val Ile Ala Gly Ala Pro Glu Ala Val Asp Ser Val Leu Ala Ala His
660 665 670
Gln Asp Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr
675 680 685
Pro His Val Glu Lys Ile Arg Asp Glu Leu Leu Pro Met Leu Ala Asp
690 695 700
Ile Asp Ser Gln Thr Pro Leu Val Pro Trp Leu Ser Thr Val Asp Gly
705 710 715 720
Leu Phe Ile Glu Gly Pro Leu Lys Ala Asp Tyr Trp Tyr Arg Asn Leu
725 730 735
Arg Glu Gln Val Gly Phe Asp Thr Ala Val Asn Gln Leu Pro Asp Ser
740 745 750
Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Gly Met Gly
755 760 765
Asp Ala Leu Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Glu
770 775 780
Arg Leu Val Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val
785 790 795 800
Asp Trp Ala Ala Val Ile Tyr Asn Thr Thr Ala Leu Val Asp Leu Pro
805 810 815
Thr Tyr Pro Phe Gln His Glu His Tyr Trp Leu Asp Ser Thr Arg Leu
820 825 830
Met Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala Leu Val Ala Val Val
835 840 845
Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Arg Ala Ile
850 855 860
Pro Ala Thr Ala Ala Phe Arg Glu Leu Gly Val Asp Ser Leu Thr Ala
865 870 875 880
Val Gln Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro
885 890 895
Thr Thr Leu Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala Arg
900 905 910
Leu
<210> 103
<211> 910
<212> PRT
<213> Catellatospora ferruginea
<400> 103
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Leu Pro Thr Asp Arg Gly Trp Asp Leu Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Gly Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Val Ala Asp Phe Asp Pro Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Asn Gly Tyr
115 120 125
Gly Ile Asp Thr Asp Gly Gly Gly Phe Gly Ala Thr Ala Gly Thr Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Gly Cys Ser Ser Ala Leu Val Ala Leu His
165 170 175
Gln Ala Arg Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Ser Pro Tyr Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Met Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala
275 280 285
Asn Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ser Val Asp Arg Pro Pro Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ala Val Pro Ala Pro Pro Phe Glu Pro Pro Thr Pro Val Thr
420 425 430
Gly Pro Val Pro Leu Val Ile Ser Ala Lys Thr Arg Pro Ala Leu Thr
435 440 445
Ala Phe Glu Ala Arg Leu Arg Ala Tyr Val Thr Ala Asp Ala Asp Leu
450 455 460
Thr Ala Ile Ala Ser Thr Leu Ala Thr Thr Arg Ser Ile Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Val Pro
485 490 495
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
500 505 510
Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg
515 520 525
Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu
530 535 540
Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val
545 550 555 560
Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln
565 570 575
Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu
580 585 590
Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala
595 600 605
Gln Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly His
610 615 620
Gly Ala Met Ala Ser Ile Ala Leu Ser Ala Asp Gln Ile Thr Leu Thr
625 630 635 640
Asp Gly Ala Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile
645 650 655
Ala Gly Ala Pro Ala Ala Val Asp Ser Val Leu Ala Ala His Glu Asp
660 665 670
Ala Arg Thr Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His
675 680 685
Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Leu Asp
690 695 700
Ser Arg Ala Pro Val Ile Pro Trp Leu Ser Thr Val Asp Val Thr Trp
705 710 715 720
Val Glu Gly Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu
725 730 735
Pro Val Gly Phe Asp Thr Ala Val Glu Asn Leu Pro Asp Ser Val Phe
740 745 750
Ile Glu Val Ser Ala Asn Pro Val Leu Leu Pro Ala Met Gly Asp Ala
755 760 765
Leu Thr Val Ala Thr Leu Arg Arg Asp Ala Gly Gly Gln Thr Arg Leu
770 775 780
Leu Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp
785 790 795 800
Val Thr Val Ile Gly Ala Thr Pro Ala Arg Val Asp Leu Pro Thr Tyr
805 810 815
Ala Phe Gln His Gln Arg Tyr Trp Val Ala Asp Arg Leu His Asp Arg
820 825 830
Pro Ser Ala Glu Gln His Arg Leu Met Arg Glu Leu Val Gln Arg His
835 840 845
Ala Ala Thr Val Leu Gly His Ala Ser Pro Asp Thr Ile Ala Ala Asp
850 855 860
Arg Pro Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu
865 870 875 880
Arg Asn His Leu Val Ala Glu Thr Gly Leu Arg Leu Ser Ala Thr Thr
885 890 895
Ala Phe Asp His Pro Thr Ala Asp Asp Leu Ala Gly His Leu
900 905 910
<210> 104
<211> 954
<212> PRT
<213> Catellatospora ferruginea
<400> 104
Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Ala Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Glu Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Ile Gly Ala Thr Asp Gln Gln Gln Glu Asn Leu Ile Thr Gly Ser
130 135 140
Ser Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu
145 150 155 160
Gly Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala
180 185 190
Leu Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe
210 215 220
Ser Ala Ala Ala Asp Gly Thr Thr Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Val Leu Gln Arg Leu Ser Glu Ala Val Arg Glu Gly His Arg Val Leu
245 250 255
Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Val Ser Gln Gln Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Gly Ala Gly Leu Thr Ala Ser Glu Val Asp Val Val Glu Ala
290 295 300
His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile
305 310 315 320
Leu Ala Thr Tyr Gly Gln Asp Arg Asp Ala Pro Ala Trp Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly
340 345 350
Val Ile Lys Met Val Gln Ala Met Arg His Gly Leu Leu Pro Arg Thr
355 360 365
Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Arg Gly Asp
370 375 380
Ile Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Gly Thr Arg Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His
405 410 415
Val Val Leu Glu Glu Tyr Pro Ala Pro Val Ala Ala Ala Pro Pro Val
420 425 430
Thr Pro Ala Arg Gly Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser
435 440 445
Pro Asn Ala Leu Arg Glu Gln Ala Ala Arg Leu Tyr Ala Ala Leu Ala
450 455 460
Glu Asp Pro Asp Trp His Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr
465 470 475 480
Thr Arg Pro Gly Phe Pro His Arg Ala Val Ala Val Gly Ser Asp Arg
485 490 495
Glu Asp Phe Gln Arg Ala Leu Ser Lys Leu Ala Asp Gly Ala Gly Trp
500 505 510
Pro Gly Leu Ile Thr Ala Thr Ala Ala Lys Asp Arg Arg Val Ala Phe
515 520 525
Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Gly Leu
530 535 540
His Arg Arg Phe Pro Val Phe Ala Arg Ala Trp Asp Ala Val Ser Ala
545 550 555 560
Ala Phe Ala Lys His Leu Asp His Ser Leu Thr Asp Ile Tyr Leu Gly
565 570 575
Glu Ser Ser Pro Thr Asn Thr Asp Leu Ala Asp Asp Thr Leu Tyr Ala
580 585 590
Gln Ala Gly Ile Phe Thr Leu Glu Val Ala Leu Val Glu Leu Leu Gln
595 600 605
Asp Trp Gly Val Arg Pro Asp Phe Val Thr Gly His Ser Ile Gly Glu
610 615 620
Ala Ala Ala Ala Tyr Val Ala Gly Val Leu Ser Leu Glu Asp Val Thr
625 630 635 640
Ala Leu Ile Val Ala Arg Gly Lys Ala Leu Arg Leu Thr Pro Pro Gly
645 650 655
Asp Met Val Ala Leu Arg Ala Gly Glu Ala Asp Val Arg Asp Phe Leu
660 665 670
Asn Arg Thr Gly Ala Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Glu
675 680 685
Ala Val Val Val Ser Gly Thr Pro Asp Ala Val Ala Asp Phe Arg Ala
690 695 700
Ala Trp Thr Ala Ser Gly Gly Gln Ala Arg Asn Leu Thr Val Arg His
705 710 715 720
Ala Phe His Ser Arg His Val Glu Ser Ala Leu Asp Glu Phe Arg Thr
725 730 735
Thr Leu Glu Thr Leu Thr Phe Arg Ala Pro Lys Val Pro Leu Val Ser
740 745 750
Thr Ala Thr Gly Arg Leu Val Gly Pro Ala Glu Leu Gly Ala Pro Glu
755 760 765
Tyr Trp Leu Arg Gln Val Arg Gln Thr Val Arg Phe Glu Asp Ala Leu
770 775 780
Arg Asp Leu Ser Gly Arg Gly Val Gly Thr Phe Val Glu Ile Gly Pro
785 790 795 800
Ser Gly Ser Leu Ala Thr Ala Gly Leu Glu Cys Leu Gly Asp Asp Ala
805 810 815
Ser Phe His Ala Val Gln Arg Pro Arg Ser Pro Glu Asp Val Cys Leu
820 825 830
Met Thr Ala Val Ala Glu Leu His Ala Gly Gly Thr Thr Val Asp Trp
835 840 845
Ala Lys Val Leu Ala Gly Gly Arg Thr Val Asp Leu Pro Val Tyr Pro
850 855 860
Phe Gln His Arg Pro Tyr Trp Ile Ala Pro Ala Ser Tyr Pro Asp Glu
865 870 875 880
Pro Arg Thr Met Arg Glu Leu Val Arg Leu Glu Val Ala Gly Ile Leu
885 890 895
Gly Leu Ser Asp Pro Ser Val Ile Leu Asp Asp Ser Ser Phe Leu Glu
900 905 910
Leu Gly Phe Asp Ser Leu Ser Ser Leu Arg Leu Gly Asn Arg Leu Ala
915 920 925
Thr Val Thr Gly Leu Asp Leu Pro Ser Thr Leu Leu Phe Asp Tyr Ala
930 935 940
Thr Pro Ala Ala Leu Ala Thr His Leu Asp
945 950
<210> 105
<211> 906
<212> PRT
<213> Catellatospora ferruginea
<400> 105
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Val Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Ala Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr
115 120 125
Gly Thr Glu Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Ala Lys Gly His Arg Ile Gln Ala Met Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Gln Asn Gln Pro Trp Pro Ser Phe Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Ile Ile Leu Glu
405 410 415
Ser Ala Pro Ala Gln Pro Leu Ala Pro Ser Thr Pro Ile Pro Gly Leu
420 425 430
Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Phe
435 440 445
Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala
450 455 460
Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His Arg Ala
465 470 475 480
Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Ala Pro Asp Pro
485 490 495
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
500 505 510
Gly Ser Ala Leu Cys Glu Ser Ser Val Val Phe Ala Ser Arg Met Ala
515 520 525
Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ser
530 535 540
Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala
565 570 575
Gly Val His Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Cys Leu Ala Gly Ala Ile Ser Leu Gln Asp Gly Ala Arg Val
595 600 605
Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala
610 615 620
Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Ala Leu Thr Asp Gly
625 630 635 640
Ala Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly
645 650 655
Ala Pro Glu Ala Val Asp Ser Val Leu Ala Ala His Gly Asp Ala Arg
660 665 670
Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu
675 680 685
Gln Ile Arg Ala Glu Leu Leu Ala Ile Leu Ala Asp Ile Asp Ser Arg
690 695 700
Pro Pro Ser Ile Pro Trp Leu Ser Thr Val Asp Asp Ala Leu Val Glu
705 710 715 720
Gly Pro Leu Lys Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val
725 730 735
Gly Phe Asp Thr Ala Val Ser Ala Leu Gln Asp Ala Val Phe Ile Glu
740 745 750
Val Ser Ala Asn Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ala Thr
755 760 765
Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Gln Asp Arg Leu Leu Thr
770 775 780
Ala Val Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp Ala Ala
785 790 795 800
Val Ile Gly Ala Thr Gly Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala
805 810 815
Phe Gln His Gln Arg Phe Trp Ala Arg Ala Ala Ser Ala Ala Gly Leu
820 825 830
Ala Pro Glu Ala Leu Leu Lys Val Val Gln Asp Ser Ala Ala Gln Val
835 840 845
Leu Gly Tyr Ala Asp Pro Gly Ala Ile Ala Val Thr Ala Ala Phe Lys
850 855 860
Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Met Arg Asn Thr Leu
865 870 875 880
Ala Lys Lys Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr
885 890 895
Pro Thr Pro Gly Val Leu Ala Gly Arg Leu
900 905
<210> 106
<211> 874
<212> PRT
<213> Catellatospora ferruginea
<400> 106
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Ile Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Thr Gly Ala Asp Val Gly Gly Phe Gly Ala Thr Ala Gly Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro His Thr Phe Ile Glu Phe Ser
195 200 205
Arg Gln Gln Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Gln Lys Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Ser Val Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Val Gln Leu Pro Val Pro Ser Ala Gly Leu Ala
420 425 430
Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Asp Ala Glu
435 440 445
Ala Arg Leu Arg Gly Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile
450 455 460
Ala Ser Thr Leu Ala Thr Thr Arg Ser Met Phe Glu His Arg Ala Val
465 470 475 480
Leu Leu Gly Asp Thr Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Lys
485 490 495
Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly
500 505 510
Glu Gln Leu Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg Val Trp
515 520 525
Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr Ala
530 535 540
Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Ala Gly Leu Leu Glu
545 550 555 560
Ser Trp Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu
565 570 575
Leu Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys
580 585 590
Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly
595 600 605
Gly Val Met Val Ala Val Pro Val Ser Glu Asp Gln Ala Arg Ala Ala
610 615 620
Leu Leu Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val
625 630 635 640
Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala Gly Leu
645 650 655
Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser Ala Arg
660 665 670
Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Val Thr
675 680 685
Tyr Arg Thr Pro Val Ile Thr Met Ala Ala Gly Ala Ala Thr Pro Asp
690 695 700
Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val
705 710 715 720
Ala Ala Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp Arg Thr
725 730 735
Leu Ala Arg Leu Val Asp Gly Ile Ala Met Leu His Gly Asp Asp Glu
740 745 750
Val Glu Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln Gly Val
755 760 765
Pro Val Ala Trp Asp Asn Gly Ala Arg Val Leu Asp Leu Pro Thr Tyr
770 775 780
Pro Phe Gln His Gln Arg Tyr Trp Leu Asp Ala Arg Arg Ala Ala Ser
785 790 795 800
Ala Gly Gly Asp Leu Leu Lys Met Val Arg Asp Asn Ala Ala Leu Ile
805 810 815
Leu Gly His Thr Asn Pro Gly Ala Ile Ser Glu Thr Thr Ala Phe Arg
820 825 830
Asp Leu Gly Val Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ser Leu
835 840 845
Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr
850 855 860
Pro Thr Pro Ser Val Leu Ala Gly Arg Leu
865 870
<210> 107
<211> 870
<212> PRT
<213> Catellatospora ferruginea
<400> 107
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Val Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala
275 280 285
Thr Ala Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Gln Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Val Pro Pro Val Pro Ser Ala Gly Pro Ala
420 425 430
Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Asp Ala Glu
435 440 445
Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala Ile
450 455 460
Ala Ser Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His Arg Ser Val
465 470 475 480
Ile Phe Glu Asn His Thr Ile Thr Gly Thr Ala Ala Pro Asp Pro Arg
485 490 495
Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly
500 505 510
Glu Gln Leu Ala Ala Thr Phe Pro Val Phe Ala Glu Ile His Arg Arg
515 520 525
Val Trp Asp Leu Leu Asp Gly Pro Asp Leu Asp Val Asp Gln Thr Gly
530 535 540
Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Val Gly Leu
545 550 555 560
Leu Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val
565 570 575
Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp
580 585 590
Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro
595 600 605
Pro Gly Gly Val Met Val Ala Val Pro Val Pro Glu Asp Gln Ala Arg
610 615 620
Ala Ala Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser
625 630 635 640
Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Val Ala Ala
645 650 655
Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser
660 665 670
Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Gly Val Ala Glu Gln
675 680 685
Leu Thr Tyr Arg Thr Pro Val Ile Ser Met Ala Ala Glu Val Ala Thr
690 695 700
Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp
705 710 715 720
Gln Val Ala Glu Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp
725 730 735
Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Met Leu His Gly Asp
740 745 750
Asp Glu Val Glu Ala Ala Leu Asn Gly Leu Ala Arg Leu Phe Val Gln
755 760 765
Gly Val Pro Val Ala Trp Asp Asn Gly Gly Arg Val Leu Asp Leu Pro
770 775 780
Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Val Ser Pro Glu Ala
785 790 795 800
Leu Leu Lys Ala Val Arg Asp Ser Ala Ala Met Ile Leu Gly His Ala
805 810 815
Asp Pro Ser Ala Ile Ser Glu Thr Ala Ala Phe Arg Asp Leu Gly Val
820 825 830
Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr
835 840 845
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala
850 855 860
Val Leu Ala Ala Arg Leu
865 870
<210> 108
<211> 875
<212> PRT
<213> Catellatospora ferruginea
<400> 108
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Ala Ala Ser Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr
115 120 125
Gly Ala Arg Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Thr Pro Gln Ile Phe Val Asp Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Gly Asp Asn Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Pro Thr Leu His Ala Asp
355 360 365
Gln Pro Ser Gln His Val Asp Trp Ser Thr Gly Ala Val Glu Leu Val
370 375 380
Thr Gln Ser Gln Pro Trp Pro Ser Val Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Val Pro Ala Gln Pro Pro Val Pro Ser Ala Gly Pro Ala Pro Leu
420 425 430
Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Glu Ala Glu Ala Arg
435 440 445
Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile Ala Ser
450 455 460
Thr Leu Ala Thr Thr Arg Ser Ile Phe Glu His Arg Ala Val Leu Leu
465 470 475 480
Gly Asp Thr Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Lys Val Val
485 490 495
Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Gln
500 505 510
Leu Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg Val Trp Asp Leu
515 520 525
Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr Ala Gln Pro
530 535 540
Ala Leu Phe Ala Leu Gln Val Ala Leu Ala Gly Leu Leu Glu Ser Trp
545 550 555 560
Gly Val Arg Pro Gln Ala Val Ile Gly His Ser Val Gly Glu Leu Ala
565 570 575
Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu
580 585 590
Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val
595 600 605
Met Val Ala Val Pro Val Ser Glu Glu Gln Ala Arg Ala Ala Leu Thr
610 615 620
Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu
625 630 635 640
Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala Gly Leu Gly Lys
645 650 655
Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser Ala Arg Met Glu
660 665 670
Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Leu Thr Tyr Arg
675 680 685
Thr Pro Thr Ile Thr Met Thr Glu Glu Val Thr Thr Pro Asp Tyr Trp
690 695 700
Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala
705 710 715 720
Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp Arg Thr Leu Ala
725 730 735
Arg Leu Ile Asp Gly Ile Ala Met Leu His Gly Asp Asp Glu Thr Glu
740 745 750
Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln Gly Val Pro Val
755 760 765
Thr Trp Asp Asn Lys Ala Arg Val Leu Asp Leu Pro Thr Tyr Pro Phe
770 775 780
Gln Arg Gln Arg Tyr Trp Ala Gly Trp Leu Ala Gly Leu Ala Ala Glu
785 790 795 800
Glu Arg Asp Lys Ala Leu Val Thr Val Val Arg Asp Ser Val Ala Ala
805 810 815
Val Leu Gly Tyr Ala Asp Ser Arg Lys Ile Pro Val Ser Ala Ala Phe
820 825 830
Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser
835 840 845
Leu Ala Lys Thr Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp
850 855 860
His Pro Thr Leu Ala Thr Leu Ala Ala Arg Leu
865 870 875
<210> 109
<211> 901
<212> PRT
<213> Catellatospora ferruginea
<400> 109
Glu Pro Leu Ala Ile Val Gly Val Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Ala Leu Trp Gln Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe
35 40 45
Asp Pro Asp Pro Glu Ala Ser Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Val Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asn Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr
115 120 125
Gly Ser Asp Leu Glu Gly Phe Ser Ala Thr Ala Gly Ala Gly Ser Val
130 135 140
Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Ala Thr Val Met Ala Thr Pro Gln Thr Phe Ile Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly Asp Asn Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Ala Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Ala Pro Gln Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg Gln Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Glu Asn Gln Pro Trp Pro Asp Val Asp Arg Pro Arg Arg Ala Ala
385 390 395 400
Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Ala Gln Pro Val Ala Pro Ser Thr Pro Ala Thr Gly Leu
420 425 430
Thr Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Ser
435 440 445
Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala
450 455 460
Ile Ala Ala Thr Leu Ala Ala Thr Arg Ser Ala Phe Glu His Arg Ala
465 470 475 480
Val Leu Leu Gly Asp Asp Thr Val Thr Gly Ile Ala Ala Pro Asp Pro
485 490 495
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
500 505 510
Gly Ser Ala Leu Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Ala
515 520 525
Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu Phe Ser
530 535 540
Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala
565 570 575
Gly Val Arg Pro Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Gly Ala Lys Ile
595 600 605
Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala
610 615 620
Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp Gly
625 630 635 640
Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly
645 650 655
Ala Pro Glu Ala Val Asp Ser Val Leu Ser Ala His Gly Asp Ala Arg
660 665 670
Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu
675 680 685
Gln Ile Arg Thr Glu Leu Leu Pro Ile Leu Ala Asp Ile Asp Ser Gln
690 695 700
Thr Pro Arg Ile Pro Trp Leu Ser Thr Val Asp Asp Thr Trp Ile Glu
705 710 715 720
Gly Pro Leu Gly Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Gln Val
725 730 735
Gly Phe Asp Thr Ala Val Glu His Leu Gln Asp Ser Val Phe Ile Glu
740 745 750
Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ile Thr
755 760 765
Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Asp Arg Leu Val Thr
770 775 780
Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Pro Val Asp Trp Ala Ala
785 790 795 800
Val Ile Asp Asn Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala
805 810 815
Phe Gln His Gln Arg Phe Trp Val Ala Asn Leu Thr Pro Glu Ala Leu
820 825 830
Leu Lys Ala Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp
835 840 845
Pro Gly Thr Ile Pro Glu Thr Ala Ala Phe Lys Asp Leu Gly Ile Asp
850 855 860
Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Thr Thr Gly
865 870 875 880
Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Gly Val
885 890 895
Leu Ala Ala Arg Leu
900
<210> 110
<211> 882
<212> PRT
<213> Catellatospora ferruginea
<400> 110
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly Asp Ala
20 25 30
Ile Ser Asp Phe Pro Val Asp Arg Gly Trp Asp Val Asp Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Val Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Tyr Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Tyr Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Arg His Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Thr Ala Gly Leu Ser Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Asp Arg Pro Leu Leu Leu Gly Ser Val Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Pro Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Asp
370 375 380
Leu Val Thr Glu Asn Arg Pro Trp Pro Asp Leu Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Val Pro Pro Val Pro Ser Ala Gly Pro Ala
420 425 430
Pro Leu Met Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Glu Ala Glu
435 440 445
Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Pro Ala Ile
450 455 460
Ala Ser Thr Leu Ala Ser Thr Arg Ser Thr Phe Glu His Arg Ala Val
465 470 475 480
Ile Phe Gln Asn His Thr Ile Thr Gly Thr Ala Ala Ala Asp Pro Arg
485 490 495
Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly
500 505 510
Glu Gln Leu Ala Ala Thr Phe Pro Val Phe Lys Asp Ile His Arg Arg
515 520 525
Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly
530 535 540
Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu
545 550 555 560
Leu Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val
565 570 575
Gly Glu Leu Ala Ala Gly Tyr Val Ala Gly Leu Trp Ser Leu Glu Asp
580 585 590
Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro
595 600 605
Pro Gly Gly Val Met Val Ala Val Ala Val Ser Glu Glu His Ala Gln
610 615 620
Ala Ala Leu Ile Lys Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser
625 630 635 640
Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln Val Ala Ala
645 650 655
Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser
660 665 670
Ala Arg Met Glu Pro Met Leu Glu Lys Phe Arg Ala Val Ala Glu Gln
675 680 685
Leu Thr Tyr Arg Thr Pro Val Ile Thr Met Ala Ala Glu Val Thr Thr
690 695 700
Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp
705 710 715 720
Gln Val Ala Ala Phe Glu Gly Ala Thr Phe Val Glu Ile Gly Pro Asp
725 730 735
Arg Thr Leu Ala Arg Leu Val Asp Gly Ile Ala Met Leu His Gly Asp
740 745 750
Asp Glu Val Glu Ala Ala Leu Thr Gly Leu Ala Arg Leu Phe Val Gln
755 760 765
Gly Val Pro Val Thr Trp Asp Asn Gly Gly Arg Val Leu Asp Leu Pro
770 775 780
Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala Thr Ser Thr Arg Trp
785 790 795 800
Leu Ala Gly Leu Thr Pro Gln Glu Arg Glu Asn Ala Leu Leu Lys Val
805 810 815
Val Arg Asp Asn Ala Ala Val Val Leu Gly His Ala Gly Ala Gly Ala
820 825 830
Ile Pro Ala Thr Ala Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr
835 840 845
Ala Val Glu Leu Arg Asn Ser Leu Ala Thr Thr Thr Gly Leu Arg Leu
850 855 860
Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Val Ala Ala
865 870 875 880
Arg Leu
<210> 111
<211> 902
<212> PRT
<213> Catellatospora sp.
<400> 111
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Ser Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Ser Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr
115 120 125
Gly Thr Glu Leu Glu Gly Phe Gly Val Thr Ala Gly Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Ser Pro Gln Ser Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Ile Asp
355 360 365
Glu Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Gln Asn Gln Pro Trp Pro Gly Asn Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Thr Gln Pro Ala Leu Pro Ser Val Thr Ala Thr Gly Pro
420 425 430
Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Thr Ala Phe
435 440 445
Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala Asp Leu Thr Ala
450 455 460
Ile Ala Ala Thr Leu Ala Thr Thr Arg Ala Thr Phe Asp His Arg Ala
465 470 475 480
Val Leu Leu Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Glu Pro
485 490 495
Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met
500 505 510
Gly Ser Ala Leu Ser Glu Ser Ser Val Val Phe Ala Glu Arg Met Ala
515 520 525
Glu Cys Ala Thr Ala Leu Asp Glu Phe Val Asp Trp Asp Leu Phe Ser
530 535 540
Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro
545 550 555 560
Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala Ala
565 570 575
Gly Val His Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala
580 585 590
Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Gly Ala Arg Ile
595 600 605
Val Ala Leu Arg Ser Gln Leu Ile Ala Arg Leu Ala Gly His Gly Ala
610 615 620
Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp Gly
625 630 635 640
Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr Val Ile Ala Gly
645 650 655
Asp Pro Ala Ala Val Asp Ser Val Leu Ala Ala His Gln Asp Ala Arg
660 665 670
Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu
675 680 685
Gln Ile Arg Ala Glu Leu Leu Ala Ile Leu Ser Asp Ile Gly Ser Gln
690 695 700
Thr Pro Val Ile Pro Trp Leu Ser Thr Val Asp Gly Glu Trp Val Glu
705 710 715 720
Gly Pro Leu Gly Asn Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Thr Val
725 730 735
Gly Phe Asp Thr Ala Val Gly Leu Leu Pro Asp Ser Val Phe Ile Glu
740 745 750
Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Val Thr
755 760 765
Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Leu Thr Arg Leu Leu Thr
770 775 780
Ala Leu Ala Glu Ala Trp Val Gln Gly Val Ala Val Asp Trp Ala Ile
785 790 795 800
Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln
805 810 815
His Gln His Tyr Trp Ala Val Thr Gly Thr Gly Leu Thr Pro Glu Ala
820 825 830
Leu Leu Lys Val Val Gln Asp Ser Thr Ala Gln Val Leu Gly Tyr Thr
835 840 845
Asp Ala Ala Ala Ile Ala Val Thr Ala Ala Phe Lys Asp Leu Gly Ile
850 855 860
Asp Ser Leu Thr Ala Val Glu Met Arg Asn Thr Leu Ala Lys Ala Thr
865 870 875 880
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser
885 890 895
Leu Leu Ala Gly Arg Leu
900
<210> 112
<211> 888
<212> PRT
<213> Catellatospora sp.
<400> 112
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ser Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Arg Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Thr Gly Val Asp Val Gly Gly Phe Gly Ala Thr Ala Gly Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro His Thr Phe Ile Glu Phe Ser
195 200 205
Arg Gln Gln Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asp Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu His Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Asn
370 375 380
Leu Val Thr Glu Asn Leu Pro Trp Pro Ser Leu Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Gln Pro Pro Val Ser Ser Thr Gly Pro Ala
420 425 430
Pro Leu Val Ile Ser Ala Lys Thr Gly Pro Ala Leu Thr Ala Phe Glu
435 440 445
Ala Arg Leu Arg Thr Tyr Leu Ala Ala Ala Ser Glu Val Asp Leu Gly
450 455 460
Ala Val Ala Ala Thr Leu Ala Thr Thr Arg Ser Val Phe Glu His Arg
465 470 475 480
Ala Val Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp
485 490 495
Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
500 505 510
Met Gly Glu Gln Leu Ala Asp Ala Phe Pro Val Phe Ala Asp Ile His
515 520 525
Arg Arg Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asn Gln
530 535 540
Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe
545 550 555 560
Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His
565 570 575
Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu
580 585 590
Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala
595 600 605
Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln
610 615 620
Ala Arg Gly Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly
625 630 635 640
Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val
645 650 655
Ala Ser Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe
660 665 670
His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Gln Ala Val Ala
675 680 685
Glu Gln Leu Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu
690 695 700
Glu Val Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val
705 710 715 720
Arg Phe Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu
725 730 735
Val Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met
740 745 750
Leu His Gly Asp Asp Glu Pro Ser Ala Ala Leu Thr Gly Leu Ala Thr
755 760 765
Leu Phe Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Val Ser Gly
770 775 780
Thr Glu Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln
785 790 795 800
Arg Tyr Trp Leu Asp Arg Lys Ala Ala Arg Arg Ala Ala Ser Ala Gly
805 810 815
Gly Asp Leu Leu Lys Met Val Arg Gly Asn Ala Ala Leu Ile Leu Gly
820 825 830
His Ala Asp Pro Ser Ala Ile Ala Ala Thr Thr Ala Phe Arg Glu Leu
835 840 845
Gly Val Asp Ser Leu Thr Ala Val Gln Leu Arg Asn Ser Leu Ala Lys
850 855 860
Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr
865 870 875 880
Pro Ala Val Leu Ala Gly Arg Leu
885
<210> 113
<211> 880
<212> PRT
<213> Catellatospora sp.
<400> 113
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Pro Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Ile His Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Gln Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Ala Gly Tyr
115 120 125
Gly Ala Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Gln Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Asn
370 375 380
Leu Val Thr Gln Asn Gln Pro Trp Pro Asp Ile Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Ser Pro Pro Val Pro Ser Thr Gly Pro Ala
420 425 430
Pro Leu Val Ile Ser Ala Lys Thr Val Pro Ala Leu Thr Ala Phe Glu
435 440 445
Ala Arg Leu Arg Thr Tyr Leu Ala Ala Val Pro Glu Val Asp Leu Gly
450 455 460
Ala Val Ala Ala Thr Leu Ala Thr Thr Arg Ala Thr Phe Glu His Arg
465 470 475 480
Ala Val Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp
485 490 495
Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
500 505 510
Met Gly Glu Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Asp Ile His
515 520 525
His Arg Val Trp Glu Leu Leu Asp Ile Pro Asp Leu Asp Val Asp Gln
530 535 540
Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe
545 550 555 560
Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His
565 570 575
Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu
580 585 590
Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala
595 600 605
Leu Pro Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln
610 615 620
Ala Arg Ala Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly
625 630 635 640
Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val
645 650 655
Ala Ser Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe
660 665 670
His Ser Ala Arg Val Glu Pro Met Leu Glu Glu Phe Arg Val Ile Ala
675 680 685
Gly Gln Leu Thr Tyr Arg Thr Pro Val Ile Glu Met Ala Ala Gly Glu
690 695 700
Gln Val Thr Ser Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val
705 710 715 720
Arg Phe Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu
725 730 735
Ile Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Leu
740 745 750
Leu His Gly Asp Asp Glu Thr Glu Ala Ala Met Ala Gly Leu Ala Arg
755 760 765
Leu Phe Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Leu Gly Gly
770 775 780
Thr Glu Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln
785 790 795 800
Arg Tyr Trp Ala Ala Leu Thr Pro Glu Ala Leu Leu Lys Val Val Arg
805 810 815
Asp Ser Ala Ala Met Val Leu Gly His Ala Asp Pro Ser Ala Ile Ser
820 825 830
Gly Thr Ala Ala Phe Arg Asp Leu Gly Leu Asp Ser Leu Thr Ala Val
835 840 845
Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala
850 855 860
Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser Val Leu Ala Gly Arg Leu
865 870 875 880
<210> 114
<211> 886
<212> PRT
<213> Catellatospora sp.
<400> 114
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Pro Asp Arg Gly Trp Asp Thr Ala Ser Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Val Ala Glu Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ala Gly Tyr
115 120 125
Gly Ala His Leu Glu Gly Phe Gly Ala Thr Ala Gly Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Leu Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Ala Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Thr Pro Gln Ile Phe Val Asp Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Asp Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Thr Ser Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Ile Val Pro Arg Thr Leu His Val Asp
355 360 365
Gln Pro Ser Gln His Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Glu Asn Gln Pro Trp Pro Ser Leu Asp Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Val Pro Ala Ser Pro Pro Val Pro Ser Thr Gly Pro Ala Pro Leu
420 425 430
Val Ile Ser Ala Lys Thr Gly Pro Ala Leu Thr Ala Phe Glu Ala Arg
435 440 445
Leu Arg Thr Tyr Leu Ala Ala Thr Pro Asp Ala Asp Leu Pro Thr Ile
450 455 460
Ala Ser Thr Leu Ala Thr Thr Arg Ser Val Phe Glu His Arg Ala Val
465 470 475 480
Leu Leu Gly Glu Glu Thr Ile Ala Gly Thr Ala Ala Val Asp Pro Arg
485 490 495
Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly
500 505 510
Glu Gln Leu Ala Asp Ala Phe Pro Val Phe Ala Asp Ile His Arg Arg
515 520 525
Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asn Gln Thr Gly
530 535 540
Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu
545 550 555 560
Leu Glu Ser Trp Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Ile
565 570 575
Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp
580 585 590
Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro
595 600 605
Pro Gly Gly Val Met Val Ala Val Pro Val Ser Glu Glu Gln Ala Arg
610 615 620
Gly Val Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser
625 630 635 640
Ser Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val Ala Ser
645 650 655
Gly Leu Gly Lys Trp Thr Arg Leu Ser Thr Ser His Ala Phe His Ser
660 665 670
Ala Arg Met Glu Pro Met Leu Glu Glu Phe Gln Ala Val Ala Glu Gln
675 680 685
Leu Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu Glu Val
690 695 700
Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe
705 710 715 720
Gly Glu Gln Val Ala Ala Phe Ser Asp Ala Val Phe Val Glu Val Gly
725 730 735
Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met Leu His
740 745 750
Gly Asp Asp Glu Pro Ser Ala Ala Gly Thr Ala Leu Ala Arg Leu His
755 760 765
Val Gln Gly Val Pro Val Asp Trp Ser Ala Val Leu Gly Gly Thr Gly
770 775 780
Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr
785 790 795 800
Trp Ala Gly Trp Leu Ala Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala
805 810 815
Leu Val Thr Val Val Arg Asp Ser Val Ala Ala Val Leu Gly Tyr Ala
820 825 830
Asp Ser Arg Lys Ile Ala Leu Ser Ala Ser Phe Lys Glu Leu Gly Val
835 840 845
Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Thr Thr
850 855 860
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Leu Ala
865 870 875 880
Ala Met Ala Ala Arg Leu
885
<210> 115
<211> 902
<212> PRT
<213> Catellatospora sp.
<400> 115
Glu Pro Leu Ala Ile Val Gly Val Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Ala Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu Phe
35 40 45
Asp Pro Asp Pro Glu Ala Ser Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Val Cys Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Ser Gly Tyr
115 120 125
Gly Ser Asp Leu Glu Gly Phe Ser Ala Thr Ala Gly Ala Gly Ser Val
130 135 140
Leu Ser Gly Arg Ile Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Ala Thr Val Met Ala Thr Pro Gln Thr Phe Ile Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Gly Asp Asn Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Ala Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Ser Val Val Pro Gln Thr Leu His Val Asp
355 360 365
Ala Pro Ser Arg Gln Val Asp Trp Ser Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Gln Asn Gln Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Ala
385 390 395 400
Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Ala Gln Pro Pro Ala Pro Ser Thr Pro Val Thr Gly Pro
420 425 430
Val Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala Leu Gly Gln Ala
435 440 445
Glu Ala Arg Leu Arg Thr Tyr Leu Ala Asp Lys Pro Asp Ala Asp Leu
450 455 460
Ala Ala Ile Ala Ala Thr Leu Ala Thr Thr Arg Ser Thr Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Arg Gly Val Ala Val Pro
485 490 495
Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu
500 505 510
Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg
515 520 525
Met Ala Glu Cys Ala Ala Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu
530 535 540
Phe Ser Val Leu Asp Asp Leu Ala Val Val Asp Arg Val Asp Val Val
545 550 555 560
Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln
565 570 575
Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu
580 585 590
Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala
595 600 605
Gln Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly Gln
610 615 620
Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr
625 630 635 640
Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Leu Ala Ala Thr Val Ile
645 650 655
Ala Gly Asp Pro Ala Ala Val Asp Gly Val Leu Ala Ala His Gln Asp
660 665 670
Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His
675 680 685
Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Ile Ser
690 695 700
Ser Arg Thr Pro Ala Ile Pro Trp Leu Ser Thr Val Asp Ser Thr Trp
705 710 715 720
Ile Glu Gly Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu
725 730 735
Pro Val Gly Phe Asp Thr Ala Val Asn Leu Leu Pro Asp Ser Val Phe
740 745 750
Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala
755 760 765
Ala Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Ser Gln Thr Arg Leu
770 775 780
Leu Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Ile Asp Trp
785 790 795 800
Thr Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala
805 810 815
Phe Gln His Gln Arg Phe Trp Val Ala Asn Ala Leu Thr Pro Glu Ala
820 825 830
Leu Leu Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala
835 840 845
Asp Pro Gly Thr Ile Pro Glu Thr Ala Ala Phe Lys Asp Leu Gly Val
850 855 860
Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr
865 870 875 880
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ser
885 890 895
Val Leu Ala Gly Arg Leu
900
<210> 116
<211> 886
<212> PRT
<213> Catellatospora sp.
<400> 116
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Ile Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Glu Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Val Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Tyr Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Asp Gly Phe Gly Ala Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Tyr Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Arg His Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gly Ser Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ala Pro His Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Ile Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Glu His Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Val Pro Ala Gln Pro Pro Val Ser Ser Thr Gly Pro Ala
420 425 430
Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala Leu Gly Gln Ala Glu
435 440 445
Ala Arg Leu Arg Thr Tyr Leu Thr Val Asp Ala Asp Leu Pro Ala Ile
450 455 460
Ala Ala Thr Leu Ala Thr Thr Arg Ala Val Phe Glu His Arg Ala Val
465 470 475 480
Leu Leu Gly Asp Thr Thr Ile Thr Gly Val Ala Ala Asp Pro Arg Val
485 490 495
Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu
500 505 510
Gln Leu Ala Ala Ala Phe Pro Val Phe Ala Asp Thr His Arg Arg Val
515 520 525
Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val Asp Gln Thr Gly Tyr
530 535 540
Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu
545 550 555 560
Glu Ser Trp Gly Val Arg Pro Glu Ala Val Ile Gly His Ser Val Gly
565 570 575
Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala
580 585 590
Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro
595 600 605
Gly Gly Val Met Val Ala Val Ala Val Ser Glu Glu Gln Ala Arg Thr
610 615 620
Ala Leu Val Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gly Ser
625 630 635 640
Val Val Leu Ser Gly Asp Glu Ala Val Val Leu Gln Val Ala Ser Gly
645 650 655
Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala
660 665 670
Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gln Leu
675 680 685
Thr Tyr Arg Thr Pro Ala Ile Glu Met Ala Ala Gly Glu Gln Val Thr
690 695 700
Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly
705 710 715 720
Glu Gln Val Ala Ala Phe Gly Asp Ala Val Phe Val Glu Ile Gly Pro
725 730 735
Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Met Leu His Gly
740 745 750
Asp Asp Glu Thr Glu Ala Ala Met Ala Gly Leu Ala Lys Leu Phe Val
755 760 765
Glu Gly Ile Pro Val Asp Trp Ser Ala Val Leu Gly Gly Asn Ala Ala
770 775 780
Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala
785 790 795 800
Ala Ser Leu Leu Ala Gly Leu Thr Pro Glu Glu Arg Gly Asn Ala Leu
805 810 815
Leu Lys Val Val Arg Asp Asn Ala Ala Val Ile Leu Gly His Ala Gly
820 825 830
Ala Ala Ala Ile Pro Ala Thr Ala Ala Phe Arg Asp Leu Gly Val Asp
835 840 845
Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Thr Ser Thr Gly
850 855 860
Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala
865 870 875 880
Met Ala Ala Arg Leu Asp
885
<210> 117
<211> 914
<212> PRT
<213> Catellatospora sp.
<400> 117
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Phe Ser Pro Glu Asp Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Lys Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Glu Ala Thr Ala Ala Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Leu Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Gly Thr Asp Leu Gly Gly Phe Gly Ala Thr Gly Gly
130 135 140
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
145 150 155 160
Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Gln Ala Ala Tyr Ser Leu Arg Gln Arg Glu Cys Ser Leu Ala
180 185 190
Leu Val Gly Gly Val Thr Val Met Gly Thr Pro His Met Phe Val Asp
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ser Val Asp Gly Arg Cys Lys Ala Phe
210 215 220
Ala Asp Ala Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu
245 250 255
Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala
290 295 300
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
305 310 315 320
Leu Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser
325 330 335
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
340 345 350
Val Ile Lys Met Val Met Ala Leu Gln Arg Gly Val Val Pro Gln Thr
355 360 365
Leu His Val Asp Gln Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala
370 375 380
Val Asp Leu Thr Thr Glu Asn Arg Pro Trp Pro Asp Thr Asp Arg Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
405 410 415
Val Ile Leu Glu Ser Ala Pro Ala Gln Pro Pro Thr Pro Ser Thr Pro
420 425 430
Val Thr Gly Pro Val Pro Leu Val Ile Ser Ala Lys Thr Ala Ser Ala
435 440 445
Leu Gly Gln Ala Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Ala
450 455 460
Asp Leu Thr Ala Ile Ala Ala Thr Leu Ala Ile Thr Arg Ser Thr Phe
465 470 475 480
Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Val Ala
485 490 495
Thr Pro Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln
500 505 510
Trp Leu Gly Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala
515 520 525
Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Asp Glu Phe Val Asp Trp
530 535 540
Asp Leu Phe Ser Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp
545 550 555 560
Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr
565 570 575
Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp
595 600 605
Gly Ala Lys Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala
610 615 620
Gly Gln Gly Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr
625 630 635 640
Leu Thr Asp Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Ala Ala Thr
645 650 655
Val Ile Ala Gly Thr Pro Ser Ala Val Asp Ser Val Leu Ala Ala His
660 665 670
Gln Asp Ala Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr
675 680 685
Pro His Val Glu Gln Ile Arg Thr Glu Leu Leu Gly Ile Leu Ala Asp
690 695 700
Ile Asp Ser Gln Thr Pro Leu Ile Pro Trp Leu Ser Thr Met Glu Gly
705 710 715 720
Thr Trp Val Glu Gly Pro Leu His Ser Asp Tyr Trp Tyr Arg Asn Leu
725 730 735
Arg Glu Pro Val Gly Phe Asp Thr Ala Val Ser Leu Leu Pro Asp Ser
740 745 750
Val Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly
755 760 765
Asp Ala Leu Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Gly Gln Asn
770 775 780
Arg Met Phe Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val
785 790 795 800
Asp Trp Ala Ala Val Ile Gly Ala Thr Thr Ala Arg Val Leu Asp Leu
805 810 815
Pro Thr Tyr Ala Phe Gln His Glu Asp Tyr Trp Leu Asp Ser Thr Arg
820 825 830
Leu Met Gly Leu Ala Ala Glu Glu Arg Asp Lys Ala Leu Val Thr Val
835 840 845
Val Arg Glu Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Arg Ala
850 855 860
Ile Pro Val Thr Ala Ala Phe Arg Glu Leu Gly Val Asp Ser Leu Thr
865 870 875 880
Ala Val Gln Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu
885 890 895
Pro Thr Thr Leu Ala Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala Ala
900 905 910
Arg Leu
<210> 118
<211> 908
<212> PRT
<213> Catellatospora sp.
<400> 118
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Leu Pro Thr Asp Arg Gly Trp Asp Ile Asp Asn Leu Tyr
35 40 45
Asp Pro Glu Pro Gly Ala Pro Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Val Ala Asp Phe Asp Pro Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Gly Asn Gly Tyr
115 120 125
Gly Ile Asp Thr Asp Gly Gly Gly Phe Gly Ala Thr Ala Gly Thr Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Gly Cys Ser Ser Ala Leu Val Ala Leu His
165 170 175
Gln Ala Arg Tyr Ala Leu Arg Gln Gly Asp Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Ser Pro Tyr Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Met Ala Ala Asn Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Arg Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Leu Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala
275 280 285
Asn Ala Gly Leu Val Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu His Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Leu Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Arg Pro Trp Pro Ser Val Asp Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ala Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Pro Ser Pro Ala Pro Ser Thr Pro Val Thr Gly
420 425 430
Leu Val Pro Leu Val Ile Ser Ala Lys Thr Ala Pro Ala Leu Gly Gln
435 440 445
Ala Glu Ala Arg Leu Arg Asp Tyr Leu Thr Ala Asp Val Asp Leu Thr
450 455 460
Ala Ile Ala Ala Thr Leu Val Thr Thr Arg Ser Thr Phe Glu His Arg
465 470 475 480
Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Val Ala Val Pro Asp
485 490 495
Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly
500 505 510
Met Gly Ser Ala Leu Arg Glu Ser Ser Val Val Phe Ala Glu Arg Met
515 520 525
Ala Glu Cys Ala Ser Ala Leu Ser Asp Tyr Val Asp Trp Asp Leu Phe
530 535 540
Thr Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln
545 550 555 560
Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Thr Trp Gln Ala
565 570 575
Ala Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile
580 585 590
Ala Ala Ala Cys Val Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Gln
595 600 605
Ile Val Ala Leu Arg Ser Gln Leu Ile Ala Gly Leu Ala Gly His Gly
610 615 620
Ala Met Ala Ser Ile Ala Leu Pro Ala Asp Gln Ile Thr Leu Thr Asp
625 630 635 640
Gly Val Trp Ile Ala Ala Arg Asn Gly Pro Thr Ala Thr Val Ile Ala
645 650 655
Gly Asn Pro Gln Ala Val Asp Ser Val Leu Ala Ala His Gln Asp Ala
660 665 670
Arg Val Arg Arg Ile Thr Val Asp Tyr Ala Ser His Thr Pro His Val
675 680 685
Glu Gln Ile Arg Thr Glu Leu Leu Asp Leu Thr Thr Asp Val Gly Ser
690 695 700
Arg Thr Pro Ala Ile Pro Trp Leu Ser Thr Val Asp Gly Glu Trp Val
705 710 715 720
Glu Gly Pro Leu Asp Thr Asp Tyr Trp Tyr Arg Asn Leu Arg Glu Pro
725 730 735
Val Gly Phe Asp Thr Ala Val Gly Met Leu Pro Asp Ser Val Phe Ile
740 745 750
Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Gly Asp Ala Ala
755 760 765
Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Gly Gln Thr Arg Leu Leu
770 775 780
Thr Ala Leu Ala Glu Ala Tyr Val Gln Gly Val Ala Val Asp Trp Ala
785 790 795 800
Val Gly Ala Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe
805 810 815
Gln His Gln Arg Tyr Trp Val Ala Asp Arg Leu His Asp Arg Pro Gly
820 825 830
Val Glu Gln His Arg Leu Met Arg Glu Leu Val Leu Arg His Ala Ala
835 840 845
Thr Val Leu Gly His Asp Ser Pro Asp Ala Ile Ala Ala Asp His Pro
850 855 860
Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn
865 870 875 880
His Leu Val Ala Glu Thr Gly Leu Arg Leu Ser Ala Thr Thr Ala Phe
885 890 895
Asp His Pro Thr Ala Asp Asp Leu Ala Arg His Leu
900 905
<210> 119
<211> 955
<212> PRT
<213> Catellatospora sp.
<400> 119
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Ser Met Arg Gly Gly
50 55 60
Phe Leu Glu Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ala Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu
100 105 110
Arg Gly Gln Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Ile Gly Ala Thr Asp Gln Gln Gln Glu Asn Leu Ile Thr Gly Ser
130 135 140
Ser Ile Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu
145 150 155 160
Gly Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Leu Ala Gly Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala
180 185 190
Leu Val Ser Gly Val Ser Val Met Ala Thr Pro Asp Val Phe Val Glu
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe
210 215 220
Ala Ala Ser Ala Asp Gly Thr Thr Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Val Leu Gln Arg Leu Ser Glu Ala Val Arg Gln Gly His Arg Val Leu
245 250 255
Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Val Ser Gln Arg Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Ser Ala Gly Leu Ala Ala Ser Glu Val Asp Val Val Glu Ala
290 295 300
His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile
305 310 315 320
Leu Ala Thr Tyr Gly Gln Asp Arg Ala Ala Pro Ala Trp Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly
340 345 350
Val Ile Lys Met Val Glu Ala Met Arg His Gly Leu Leu Pro Arg Thr
355 360 365
Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Glu Arg Gly Asp
370 375 380
Val Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Ser Thr Arg Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His
405 410 415
Val Val Leu Glu Glu Tyr Pro Ala Pro Ala Ala Ala Asp Pro Pro Val
420 425 430
Thr Pro Ala Gly Gly Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser
435 440 445
Pro Asn Ala Leu Arg Glu Gln Ala Ala Arg Leu Tyr Ala Ala Leu Ala
450 455 460
Glu Asp Pro Asp Trp Arg Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr
465 470 475 480
Thr Arg Ala Gly Phe Pro His Arg Ala Val Ala Val Gly Ser Asp Arg
485 490 495
Glu Glu Phe Gln Arg Ala Leu Ser Lys Leu Ala Asp Gly Thr Gly Trp
500 505 510
Pro Gly Leu Ile Thr Ala Thr Ala Ala Lys Asp Arg Arg Met Ala Phe
515 520 525
Leu Phe Asp Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Lys Gly Leu
530 535 540
His Arg Arg Phe Pro Val Phe Ala Arg Ala Trp Asp Ala Val Ser Ala
545 550 555 560
Ala Phe Ala Lys His Leu Asp His Ser Leu Thr Asp Ile Tyr Leu Gly
565 570 575
Pro Ser Ser Pro Ala Ser Ala Glu Leu Ala Asp Asp Thr Leu Tyr Ala
580 585 590
Gln Ala Gly Ile Phe Thr Met Glu Val Ala Leu Val Glu Leu Leu Glu
595 600 605
Asp Trp Gly Val Arg Pro Asp Phe Val Ala Gly His Ser Ile Gly Glu
610 615 620
Ala Ala Ala Ala Tyr Thr Ala Gly Met Phe Ser Leu Glu Asp Val Thr
625 630 635 640
Ala Leu Ile Val Ala Arg Gly Arg Ala Leu Arg Leu Thr Pro Pro Gly
645 650 655
Glu Met Val Ala Leu Arg Gly Gly Glu Ala Asp Val Arg Glu Leu Leu
660 665 670
Gln Arg Thr Gly Ala Ala Leu Asp Leu Ala Ala Val Asn Ser Pro Glu
675 680 685
Ala Val Val Val Ser Gly Ala Pro Asp Ala Val Ala Glu Phe Arg Ala
690 695 700
Ala Trp Thr Ala Ser Gly Arg Arg Ala Arg Asp Leu Thr Val Arg His
705 710 715 720
Ala Phe His Ser Arg His Val Glu Ser Val Leu Asp Glu Phe Arg Ala
725 730 735
Thr Leu Ala Ala Leu Thr Phe Arg Ala Pro Ala Leu Pro Val Val Ser
740 745 750
Thr Met Thr Gly Arg Leu Ala Asp Pro Ala Glu Met Gly Thr Pro Glu
755 760 765
Tyr Trp Leu Arg Gln Val Arg Gln Thr Val Arg Phe Glu Glu Ala Val
770 775 780
Arg Glu Leu Ser Gly Gln Gly Val Gly Thr Phe Val Glu Ile Gly Pro
785 790 795 800
Ser Gly Ala Leu Ala Thr Ala Gly Leu Glu Cys Leu Gly Gly Asp Ala
805 810 815
Thr Phe His Ala Val Gln Arg Pro Arg Ala Pro Glu Asp Val Cys Leu
820 825 830
Met Thr Ala Val Ala Glu Leu His Ala Gly Gly Thr Ala Val Asp Trp
835 840 845
Thr Lys Ile Leu Ala Gly Gly Arg Pro Val Asp Leu Pro Val Tyr Pro
850 855 860
Phe Gln His Arg Pro Tyr Trp Ile Ala Pro Ala Pro Ser Tyr Pro Asp
865 870 875 880
Glu Pro Arg Thr Met Arg Glu Leu Val Arg Leu Glu Val Ala Gly Ile
885 890 895
Leu Gly Leu Ser Asp Pro Ser Val Ile Leu Asp Asp Ser Ser Phe Leu
900 905 910
Glu Leu Gly Phe Asp Ser Leu Ser Ser Met Arg Leu Gly Asn Arg Leu
915 920 925
Ala Thr Val Thr Gly Leu Asp Leu Pro Ser Thr Leu Leu Phe Glu Tyr
930 935 940
Ala Thr Pro Ala Ala Leu Ala Thr His Leu Asp
945 950 955
<210> 120
<211> 917
<212> PRT
<213> Actinoplanes sp.
<400> 120
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Arg Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Thr Val Leu Gly Gly
50 55 60
Phe Leu Asp Ser Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu His Ala Gly Ile Ala Pro Arg Ser Val
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Met Gly Ala Phe Ser Ser Gly Tyr
115 120 125
Asp Ala Glu Leu Glu Glu Phe Gly Met Thr Gly Asp Ala Val Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Ser Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Val Thr Val Leu Ala Thr Pro Lys Thr Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Ala Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Arg Ala Lys Gly His His Val Leu Gly Val Val Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Gly Ala
275 280 285
Gly Leu Ser Pro His Glu Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr
305 310 315 320
Gly Gln Asp Arg Asp Gln Pro Ala Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Ala Thr Val Pro Ala Thr Leu His Val Asp
355 360 365
Ala Pro Thr Arg His Val Asp Trp Thr Ala Gly Ala Val Glu Leu Val
370 375 380
Thr Glu Asn Arg Pro Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Ala
385 390 395 400
Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Ala Pro Ala Ala Ala Pro Glu Glu Thr Glu Pro Val Ala Pro Val
420 425 430
Val Ala Ser Asp Arg Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala
435 440 445
Ala Leu Thr Ser Thr Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala His
450 455 460
Pro Gly Thr Asp Pro Arg Ala Val Ala Ser Thr Leu Ala Thr Thr Arg
465 470 475 480
Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Asn Thr Val Thr
485 490 495
Gly Ser Val Ala Gly Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly
500 505 510
Gln Gly Trp Gln Arg Leu Gly Met Gly Arg Glu Leu Leu Ala Ala Ser
515 520 525
Pro Val Phe Ala Gly Arg Met Ala Glu Cys Ala Thr Val Leu Arg Glu
530 535 540
Phe Val Asp Trp Asp Leu Phe Thr Met Leu Asp Asp Pro Ala Val Val
545 550 555 560
Asp Arg Ile Glu Val Val Gln Pro Val Cys Trp Ala Ile Met Val Ser
565 570 575
Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile
580 585 590
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ser Gly Ala Val
595 600 605
Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Phe Arg Ser Asp Met Ile
610 615 620
Ala Arg Met Thr Gly His Gly Val Met Ala Ser Val Ala Leu His Ala
625 630 635 640
Asp Asp Ile Pro Leu Val Glu Gly Ala Trp Val Ala Ala Arg Asn Gly
645 650 655
Pro Ala Ala Thr Val Val Ala Gly Thr Pro Glu Ala Val Asp Gln Val
660 665 670
Leu Ala Ala Cys Glu Glu Arg Gly Ala Arg Val Arg Arg Ile Thr Ala
675 680 685
Gly Val Ala Ser His Thr Pro Leu Ala Glu His Val Arg Gly Glu Leu
690 695 700
Leu Asp Ala Thr Gly Gly Leu Pro Ser Arg Val Pro Asp Ile Pro Trp
705 710 715 720
Leu Ser Thr Val Asp Gly Thr Trp Val Glu Lys Pro Leu Asp Pro Ala
725 730 735
Tyr Trp Phe Arg Asn Met Arg Glu Pro Val Gly Phe Ala Pro Ala Val
740 745 750
Asp Leu Leu Arg Ala Gln Gly Asp His Val Phe Leu Glu Ile Ser Ala
755 760 765
Ser Pro Val Leu Leu Pro Ser Met Asp Asp Ala Val Thr Val Ala Thr
770 775 780
Leu Arg Arg Asp Asp Gly Ser Ala Asp Arg Met Leu Ala Ala Leu Ala
785 790 795 800
Glu Ala His Thr His Gly Val Val Val Asp Trp Pro Arg Val Leu Gly
805 810 815
Thr Ala Gly Arg Val Arg Gly Leu Pro Thr Tyr Ala Phe Gln His Gln
820 825 830
Arg Tyr Trp Ala Val Ser Arg Pro Ala Val Leu Thr Pro Asp Ala Leu
835 840 845
Leu Lys Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly Tyr Thr Asp
850 855 860
Ala Asp Ser Ile Thr Val Thr Thr Ala Phe Arg Asp Leu Gly Val Asp
865 870 875 880
Ser Leu Ser Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Ser Thr Gly
885 890 895
Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Asp
900 905 910
Leu Ala Thr His Leu
915
<210> 121
<211> 881
<212> PRT
<213> Actinoplanes sp.
<400> 121
Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Ser Asp Ala
20 25 30
Ile Ser Asp Phe Pro Asp Asp Arg Gly Trp Asp Val Gly Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Arg Ser Thr Thr Val Arg Gly Gly
50 55 60
Phe Leu Asp Glu Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Thr Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Val Ser Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Asn Ile Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Thr Asn Gly His His Ile Leu Ala Val
245 250 255
Val Arg Ala Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ala Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg Asn Gly Thr Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Ala Thr Glu Asn Arg Pro Trp Pro Glu Thr Glu Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Thr Pro Thr Gln Pro Val Glu Pro Ser Thr Pro Ala Ala
420 425 430
His Pro Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro Ala Leu Ala
435 440 445
Ala Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Ser Glu Thr Asp Leu
450 455 460
Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Val Ala Ala Leu
485 490 495
Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala
500 505 510
Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile
515 520 525
His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu Asp Ile Asp
530 535 540
Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu
545 550 555 560
Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly
565 570 575
His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Ile Ala Gly Leu Trp Ser
580 585 590
Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln
595 600 605
Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Gln Ala Thr Glu Glu
610 615 620
Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn
625 630 635 640
Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln
645 650 655
Val Ala Ala Glu Leu Gly Gly Lys Ser Ala Arg Leu Lys Thr Ser His
660 665 670
Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln
675 680 685
Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala
690 695 700
Gly Thr Thr Ser Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg
705 710 715 720
Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile
725 730 735
Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser
740 745 750
His Gly Asp Asp Glu Val Arg Ala Val Met Thr Ala Leu Ala Glu Leu
755 760 765
His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg
770 775 780
Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr Trp Leu
785 790 795 800
Ala Asn Thr Ala Ala Glu Leu Thr Ala Ala Asp Leu Leu Lys Ala Val
805 810 815
Arg Asp Ser Ala Ala Val Val Leu Gly His Ala Asp Ala Asp Ser Ile
820 825 830
Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Phe Asp Ser Leu Thr Ala
835 840 845
Ile Glu Leu Arg Asn Arg Leu Ala Lys Asp Ile Gly Leu Arg Leu Pro
850 855 860
Ala Thr Met Ala Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Ala Arg
865 870 875 880
Leu
<210> 122
<211> 887
<212> PRT
<213> Actinoplanes sp.
<400> 122
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Glu Phe Pro Thr Asp Arg Gly Trp Asp Val Gly Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Thr Thr Val His Gly Gly
50 55 60
Phe Leu Glu Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ala Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Asn Ile Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Asn Gly His Arg Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala
275 280 285
Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Ile Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Thr Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala Ser Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Ala Thr Glu Ser Arg Pro Trp Pro Lys Thr Gly Arg Ala His Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Thr Gln Pro Glu Glu Pro Ser Thr Pro Ala Pro
420 425 430
His Pro Leu Pro Leu Pro Val Ser Ala Lys Thr Ser Ala Ala Leu Thr
435 440 445
Asp Leu Glu Asp Arg Ile Arg Ala Tyr Leu Thr Pro Glu Thr Asp Leu
450 455 460
Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Met Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Thr Gly Val Ala Ala Pro
485 490 495
Asp Pro Arg Leu Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala
500 505 510
Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile
515 520 525
His Arg Glu Val Leu Asp Leu Leu Asp Val Pro Asp Leu Asp Ile Asp
530 535 540
Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu
545 550 555 560
Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly
565 570 575
His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Leu Trp Ser
580 585 590
Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln
595 600 605
Ala Leu Pro Pro Gly Gly Ala Met Val Ala Val Ala Val Pro Glu Glu
610 615 620
Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn
625 630 635 640
Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln
645 650 655
Val Ala Ala Glu Leu Gly Gly Lys Ser Thr Arg Leu Arg Thr Ser His
660 665 670
Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln
675 680 685
Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala
690 695 700
Gly Thr Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg
705 710 715 720
Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile
725 730 735
Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser
740 745 750
His Gly Asp Asp Glu Val Arg Ala Ala Met Thr Ala Leu Ala Glu Leu
755 760 765
His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg
770 775 780
Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Arg Arg Tyr Trp Val
785 790 795 800
Ala Pro Ala Arg Arg Ala Ala Gly Arg Pro Ala Asp Leu Thr Pro Glu
805 810 815
Gly Leu Leu Thr Thr Val Arg Asp Ser Ala Ala Val Val Leu Gly His
820 825 830
Ala Asp Ala Ser Ala Ile Pro Ala Thr Ala Ala Phe Gln Ala Leu Gly
835 840 845
Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Asn
850 855 860
Thr Gly Leu Arg Leu Pro Ala Thr Leu Ile Phe Asp Tyr Pro Thr Pro
865 870 875 880
Val Asp Leu Ala Thr His Leu
885
<210> 123
<211> 886
<212> PRT
<213> Actinoplanes sp.
<400> 123
Glu Pro Leu Ala Ile Ile Gly Met Ser Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Ala Asp Arg Gly Trp Asp Leu Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Arg Thr Thr Thr Val Gln Gly Gly
50 55 60
Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Ala Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Gly Ala Phe Met Leu Thr Gly Arg Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Ser Tyr Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Val Met Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Asn Leu Ala Asp Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Leu Ala Lys Gly His Arg Ile Met Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Asp
275 280 285
Ser Ala Gly Leu Thr Thr Ala Asp Val Asp Val Ile Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ala Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Ala Thr Glu Asn Arg Pro Trp Pro Glu Val Gly Arg Ala Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Phe Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Pro Ala Thr Pro Ser Ala Pro Val Ala
420 425 430
His Leu Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro Ala Leu Ala
435 440 445
Asp Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Pro Glu Ala Asp Leu
450 455 460
Pro Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val Phe Glu His
465 470 475 480
Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Ile Ala Ala Leu
485 490 495
Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ala Gln Arg Ala
500 505 510
Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe Ala Gln Ile
515 520 525
His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu Asp Ile Asp
530 535 540
Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln Val Ala Leu
545 550 555 560
Ala Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile Gly
565 570 575
His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Ile Ala Gly Leu Trp Ser
580 585 590
Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln
595 600 605
Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Gln Ala Thr Glu Asp
610 615 620
Gln Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala Ala Val Asn
625 630 635 640
Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala Val Leu Gln
645 650 655
Val Ala Ala Gly Leu Gly Gly Lys Ser Thr Arg Leu Arg Thr Ser His
660 665 670
Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln Phe Arg Gln
675 680 685
Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu Met Ala Ala
690 695 700
Gly Val Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg
705 710 715 720
Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu Val Glu Ile
725 730 735
Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Ser
740 745 750
His Gly Asp Asp Glu Val Gln Ala Ala Met Thr Ala Leu Ala Glu Leu
755 760 765
His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr Ser Ala Arg
770 775 780
Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Thr
785 790 795 800
Val Ser Trp Leu Ala Gly Leu Thr Pro Glu Glu Arg Glu Gly Ala Leu
805 810 815
Val Lys Val Val Arg Asp Ser Ala Ala Val Val Leu Gly His Ala Asp
820 825 830
Ala Gly Thr Ile Pro Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp
835 840 845
Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Arg Ser Thr Gly
850 855 860
Leu Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Leu Gly Ala
865 870 875 880
Leu Ala Ala Arg Leu Asp
885
<210> 124
<211> 914
<212> PRT
<213> Actinoplanes sp.
<400> 124
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Ala Phe Pro Ala Asp Arg Gly Trp Asp Ala Asp Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Thr Tyr Cys Val Arg Gly Gly
50 55 60
Phe Leu Asp Gly Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Ser Tyr
115 120 125
Gly Val Asp Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala Ala
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ser Thr Pro Asp Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Gly Asp
210 215 220
Gly Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Ile Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Ala
275 280 285
Asn Ala Gly Leu Ser Ser Ala Asp Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Asp
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His
355 360 365
Ala Asp Val Pro Ser Arg Gln Val Asp Trp Thr Ala Gly Ala Val Glu
370 375 380
Leu Val Thr Glu Asn Arg Ser Trp Pro Glu Ala Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Pro Pro Asp Gln Pro Thr Thr Ala Ser Ala Pro Thr Thr
420 425 430
Gly Pro Val Pro Leu Pro Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala
435 440 445
Asp Leu Glu Thr Arg Leu Arg Ala Tyr Leu Thr Pro Glu Thr Asp Leu
450 455 460
Pro Ala Val Ala Ala Thr Leu Ala Val Asn Arg Ser Leu Phe Glu His
465 470 475 480
Arg Ala Val Leu Ile Gly Asp Asp Thr Ile Thr Gly Thr Ala Ser Thr
485 490 495
Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp His Trp Leu
500 505 510
Gly Met Gly Ser Ala Leu Leu Ala Ser Ser Ala Val Phe Ala Asp Arg
515 520 525
Met Ala Glu Cys Asn Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu
530 535 540
Phe Thr Ala Leu Asp Asp Pro Ala Val Phe Asp Arg Val Asp Val Val
545 550 555 560
Gln Pro Thr Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln
565 570 575
His Ala Gly Val Arg Pro Asp Ala Val Leu Gly His Ser Gln Gly Glu
580 585 590
Ile Ala Ala Ala Cys Phe Ala Gly Ala Ile Ser Leu Gln Asp Ala Ala
595 600 605
Arg Ile Val Ala Leu Arg Ser Arg Leu Ile Gly Arg Leu Ala Gly Arg
610 615 620
Gly Ala Met Ala Ser Val Ser Leu Pro Pro Asp Glu Ile Pro Leu Ile
625 630 635 640
Asp Gly Val Thr Val Ala Val Leu Asn Gly Pro Ser Ala Val Ile Ala
645 650 655
Gly Ala Pro Asp Ala Val Asp Ala Val Leu Ala Asp Cys Glu Ala Arg
660 665 670
Gly Ala Arg Val Arg Lys Ile Asn Val Asp Tyr Ala Ser His Thr Pro
675 680 685
His Val Glu Gln Ile Arg Thr Glu Leu Leu Asp Ile Thr Ala Gly Ile
690 695 700
Thr Ala Glu Thr Pro Thr Val Pro Trp Leu Ser Thr Val Asp Gly Thr
705 710 715 720
Trp Ile Asp Arg Pro Leu Asp Thr Glu Tyr Trp Tyr Arg Asn Leu Arg
725 730 735
Glu Pro Val Gly Phe Gly Ala Thr Ile Glu Leu Leu Gln Ala Gln Gly
740 745 750
Asp Thr Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala
755 760 765
Ile Asp Asp Ser Ile Ala Ile Pro Thr Leu Arg Arg Asp Asp Gly Thr
770 775 780
Pro Thr Arg Leu Leu Thr Ala Leu Ala Glu Ala His Val His Gly Val
785 790 795 800
Thr Ile Asp Trp Ala Lys Leu Leu Gly Ser Thr Ala Ser Pro Val Asn
805 810 815
Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ala Ala Ser Ala
820 825 830
Ala Ala Gly Arg Pro Ala Glu Leu Thr Pro Glu His Leu Leu Lys Val
835 840 845
Val Arg Asp Ser Ala Ala Val Val Leu Gly His Thr Asp Ala Gly Ala
850 855 860
Ile Pro Ala Thr Ala Ala Phe Gln Ala Leu Gly Val Asp Ser Leu Ile
865 870 875 880
Ala Val Glu Leu Arg Asn Asn Leu Ala Lys Ser Thr Gly Leu Arg Leu
885 890 895
Pro Ala Thr Leu Ile Phe Asp Tyr Pro Thr Pro Ala Asp Leu Ala Thr
900 905 910
His Leu
<210> 125
<211> 948
<212> PRT
<213> Actinoplanes sp.
<400> 125
Glu Pro Leu Ala Ile Ile Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Ser Asp Ala
20 25 30
Ile Ser Asp Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Arg Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Thr Tyr Thr Thr Gln Gly Gly
50 55 60
Phe Leu Ser Glu Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Thr Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr
115 120 125
Gly Ser Gly Thr Asp Leu Ala Gly Phe Gly Val Thr Ala Gly Ala Gly
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Pro Thr Pro Arg Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Pro Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala Gly Met Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Thr Asn Gly His His Ile Leu Ala Val
245 250 255
Val Arg Ala Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ser Ala Leu Ala
275 280 285
Gly Ala Gly Leu Val Ser Ala Asp Ile Asp Val Ile Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Ser Gln Pro Val Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Ala
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Arg Asn Gly His Ala Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Ile Glu Glu Ala Pro Ala Glu Pro Pro Val Glu Pro Val Pro Ala Ala
420 425 430
Asp Val Val Val Pro Leu Val Val Ser Ala Arg Asp Ala Ile Pro Leu
435 440 445
Gly Asp Gln Ala Ala Arg Leu Ala Ala Leu Val Glu Ala Pro Asp Gly
450 455 460
Pro Val Leu Pro Ala Leu Ala Asp Ala Leu Leu Thr Arg Arg Thr Thr
465 470 475 480
Phe Ala Gln Arg Ala Val Val Val Ala Gly Ser Arg Asp Asp Ala Ala
485 490 495
Ala Gly Leu Arg Ala Leu Ala Thr Gly Thr Ala His Pro Ala Leu Val
500 505 510
Thr Gly Ala Ala Gly Thr Ser Gly Arg Val Val Leu Met Phe Pro Gly
515 520 525
Gln Gly Ser Gln Trp Asp Gly Met Gly Ala Gln Leu Ile Gly Ala Ser
530 535 540
Pro Val Phe Ala Ala Arg Ile Ala Asp Cys Ala Ala Ala Leu Gln Pro
545 550 555 560
Trp Ile Asp Trp Asp Leu Gln Asp Val Leu Arg Gly Asn Ala Pro Thr
565 570 575
Asp Leu Leu Glu Arg Val Asp Val Val Gln Pro Ala Ser Phe Ala Val
580 585 590
Met Val Gly Leu Ala Ala Val Trp Glu Ser Val Gly Val Arg Pro Asp
595 600 605
Ala Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Tyr Val Ala
610 615 620
Gly Ala Leu Thr Leu Ala Asp Ala Ala Lys Val Val Ala Val Arg Ser
625 630 635 640
Arg Leu Ile Ala Ala Arg Leu Gly Arg Gly Gly Met Ala Ser Val Ala
645 650 655
Leu Ser Pro Gln Asp Ala Ala Ala Arg Arg Gly Arg Ala Glu Leu Ala
660 665 670
Ala Val Asn Ser Pro Ala Ser Val Val Leu Ala Gly Ala Ser Glu Ala
675 680 685
Leu Asp Glu Thr Leu Ala Ala Leu Glu Ala Asp Gly Val Arg Val Arg
690 695 700
Arg Val Ala Val Asp Tyr Ala Ser His Thr Gly His Val Glu Glu Leu
705 710 715 720
Glu Gln Asp Leu Ala Glu Ala Leu Ala Asp Val Arg Ser Gln Ala Pro
725 730 735
Leu Val Gly Phe Arg Ser Thr Val Thr Gly Glu Trp Val Thr Glu Ala
740 745 750
Gly Ala Leu Asp Gly Gly Tyr Trp Tyr Arg Asn Leu Arg Gln Gln Val
755 760 765
Arg Phe Gly Pro Ala Val Ala Ala Leu Ala Glu Asp Gly Tyr Ser Val
770 775 780
Phe Val Glu Ala Ser Ala His Pro Val Leu Val Gln Pro Val Thr Glu
785 790 795 800
Thr Leu Asp Arg Thr Asp Ala Val Val Thr Gly Ser Leu Arg Arg Gln
805 810 815
Asp Gly Gly Leu Ser Arg Leu Leu Thr Ser Val Ala Glu Val Phe Val
820 825 830
Gly Gly Val Pro Val Asp Trp Ala Gly Leu Leu Pro Ala Gly Ala Gly
835 840 845
Arg Ser Trp Val Asp Leu Pro Thr Tyr Ala Phe Asp His Gln His Tyr
850 855 860
Trp Leu Pro Ala Gly Gly Thr Arg Gly Arg Ser Glu Ala Glu Leu Leu
865 870 875 880
Glu Leu Val Arg Gly Arg Ala Ala Ala Val Leu Gly His Thr Asp Ala
885 890 895
Gly Ser Ile Pro Ala Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser
900 905 910
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ser Thr Gly Leu
915 920 925
Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Val
930 935 940
Ala Ala Arg Leu
945
<210> 126
<211> 866
<212> PRT
<213> Actinoplanes sp.
<400> 126
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Ser Asp Ala
20 25 30
Ile Ser Asp Leu Pro Val Asp Arg Gly Trp Thr Val Asp Gly His Phe
35 40 45
Gln Gly Gly Phe Leu Asp Glu Val Ala Gly Phe Asp Ala Ser Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu
65 70 75 80
Val Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro
85 90 95
Gly Ser Val Arg Gly Thr Asp Ala Gly Val Phe Met Gly Ala Tyr Ala
100 105 110
Asp Gly Tyr Gly Met Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser
115 120 125
Val Ala Val Ser Val Leu Ala Gly Arg Ile Ser Tyr Phe Phe Gly Leu
130 135 140
Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Val Gly Gly Val Thr Val Met Pro Thr Pro Gln Thr Phe Val
180 185 190
Glu Phe Asp Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala
195 200 205
Phe Ala Asp Ala Ala Asp Gly Thr Ser Phe Ser Glu Gly Ala Gly Met
210 215 220
Leu Val Val Glu Arg Leu Ser Asp Ala Leu Ala Asn Gly His His Ile
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser
260 265 270
Ala Leu Ala Asn Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu
275 280 285
Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Val Ile Ala Thr Tyr Gly Gln Asn Arg Gln Arg Pro Leu Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser
325 330 335
Gly Val Ile Lys Met Val Met Ala Leu Arg Asn Gly Thr Val Pro Ala
340 345 350
Thr Leu His Val Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly
355 360 365
Ala Val Ala Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Thr Glu Arg
370 375 380
Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Thr Pro Thr Pro Pro Ala Thr Leu Ser Ala
405 410 415
Gln Val Ala His Pro Leu Pro Leu Pro Ile Ser Ala Lys Thr Pro Pro
420 425 430
Ala Leu Ala Asp Leu Glu Ala Arg Leu Arg Ala Tyr Leu Thr Pro Glu
435 440 445
Ala Asp Leu Ala Ala Val Ala Ser Thr Leu Ala Ser Thr Arg Ala Val
450 455 460
Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu Thr Ile Val Gly Val
465 470 475 480
Ala Ala Leu Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser
485 490 495
Gln Arg Ala Gly Met Gly Glu Gln Leu Ala Ala Val Phe Pro Val Phe
500 505 510
Ala Gln Ile His Arg Glu Val Leu Asp Leu Leu Asp Ile Pro Asp Leu
515 520 525
Asp Ile Asp Gln Thr Gly His Ala Gln Pro Ala Leu Phe Ala Phe Gln
530 535 540
Val Ala Leu Ala Gly Leu Leu Asp Ser Trp Gly Val Arg Pro Asp Ala
545 550 555 560
Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly
565 570 575
Leu Trp Ser Leu Gln Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg
580 585 590
Leu Met Gln Ala Leu Pro Ser Gly Gly Ala Met Val Ala Val Ala Val
595 600 605
Pro Glu Asp Glu Ala Arg Ala Val Leu Ile Asp Gly Val Glu Ile Ala
610 615 620
Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Thr Ala
625 630 635 640
Val Leu Gln Val Ala Glu Ser Leu Gly Gly Lys Ser Ala Arg Leu Lys
645 650 655
Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Gln
660 665 670
Phe Arg Gln Val Ala Glu Gln Leu Thr Tyr Arg Ser Pro Val Ile Glu
675 680 685
Met Thr Ala Gly Val Thr Pro Asp Tyr Trp Val Arg Gln Val Arg Asp
690 695 700
Thr Val Arg Phe Gly Asp Gln Val Arg Val His Gln Gly Ser Val Leu
705 710 715 720
Val Glu Ile Gly Pro Asp Arg Thr Leu Ala Arg Leu Ile Asp Gly Ile
725 730 735
Ala Thr Ser His Gly Asp Asp Glu Val Gln Ala Val Met Thr Ala Leu
740 745 750
Ala Glu Leu His Val Arg Gly Val Ala Val Asp Trp Pro Gly Thr Thr
755 760 765
Ser Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Asp His
770 775 780
Tyr Trp Ala His Pro Val Asp Arg Thr Pro Glu Ala Leu Leu Ala Leu
785 790 795 800
Val Arg Asp Ser Ala Ala Val Ala Leu Gly His Ala Gly Ala Ala Thr
805 810 815
Val Pro Ala Thr Ala Ala Phe Gln Ser Leu Gly Met Asp Ser Leu Ile
820 825 830
Ala Val Glu Leu Arg Asn Asn Leu Ala Arg Ser Thr Gly Leu Arg Leu
835 840 845
Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala Thr
850 855 860
Arg Leu
865
<210> 127
<211> 901
<212> PRT
<213> Actinoplanes sp.
<400> 127
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Leu Pro Thr Asp Arg Gly Trp Glu Glu Asp Asp Arg Phe
35 40 45
Arg Gly Gly Phe Leu Ala Gly Val Ala Gly Phe Asp Ala Ser Phe Phe
50 55 60
Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu
65 70 75 80
Val Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro
85 90 95
Gly Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro
100 105 110
Gly Gly Tyr Gly Phe Gly Ala Asp Leu Gly Gly Phe Ala Leu Thr Ser
115 120 125
Gly Ser Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu
130 135 140
Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
145 150 155 160
Ala Leu His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu
165 170 175
Ala Leu Val Gly Gly Val Thr Ile Met Pro Thr Pro Gln Thr Phe Ile
180 185 190
Glu Phe Glu Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser Lys Ala
195 200 205
Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val
210 215 220
Leu Val Val Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His His Ile
225 230 235 240
Leu Ala Val Val Arg Gly Ser Ala Ile Asn Gln Asp Gly Ala Ser Asn
245 250 255
Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser
260 265 270
Ala Leu Ala Asn Ala Gly Leu Thr Thr Ala Asp Ile Asp Val Ile Glu
275 280 285
Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala
290 295 300
Val Ile Ala Thr Tyr Gly Gln Asp Arg Ser Gln Pro Val Leu Leu Gly
305 310 315 320
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser
325 330 335
Gly Val Ile Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro Ala
340 345 350
Thr Leu His Val Asp Arg Pro Ser Arg His Val Asp Trp Ala Ala Gly
355 360 365
Ala Val Glu Leu Val Thr Glu Asn Arg Pro Trp Pro Glu Asn Gly Arg
370 375 380
Val Arg Arg Ala Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala
385 390 395 400
His Val Ile Leu Glu Ser Pro Pro Asp Gln Pro Val Lys Pro Ser Ala
405 410 415
Pro Ala Ala Gly Pro Val Pro Leu Pro Ile Ser Ala Lys Thr Pro Ala
420 425 430
Ala Leu Ala Ala Leu Glu Asn Arg Leu Arg Ala Tyr Leu Thr Pro Glu
435 440 445
Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Thr Thr Arg Ala Met
450 455 460
Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Thr Gly Thr
465 470 475 480
Ala Ser Thr Glu Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp
485 490 495
His Trp Leu Gly Met Gly Ser Ala Leu Leu Ala Ser Ser Ala Val Phe
500 505 510
Ala Asp Arg Met Ala Glu Cys Asn Ala Ala Leu His Glu Phe Val Asp
515 520 525
Trp Asp Leu Phe Thr Ala Leu Asp Asp Pro Ala Val Phe Asp Arg Val
530 535 540
Asp Ile Val Gln Pro Thr Cys Trp Ala Val Met Met Ser Leu Ala Ala
545 550 555 560
Leu Trp Gln His Ala Gly Val Arg Pro Asp Ala Val Leu Gly His Ser
565 570 575
Gln Gly Glu Ile Ala Ala Ala Cys Phe Ala Gly Ala Ile Ser Leu Gln
580 585 590
Asp Ala Ala Arg Ile Val Ala Leu Arg Ser Gln Leu Ile Gly Arg Leu
595 600 605
Ala Gly Arg Gly Ala Met Ala Ser Val Ser Leu Pro Pro Asp Glu Ile
610 615 620
Pro Leu Ile Asp Gly Val Thr Val Ala Val Leu Asn Gly Pro Ser Ala
625 630 635 640
Val Ile Ala Gly Ser Pro Glu Ala Val Asp Ala Val Leu Ala Asp Cys
645 650 655
Glu Ala Arg Gly Ala Arg Val Arg Lys Ile Asn Val Asp Tyr Ala Ser
660 665 670
His Thr Pro His Val Glu Gln Ile Arg Thr Glu Leu Leu His Ile Thr
675 680 685
Ala Ala Ile Thr Ala Glu Thr Pro Thr Val Pro Trp Leu Ser Thr Val
690 695 700
Asp Gly Thr Trp Ile Asp His Pro Leu Asp Thr Glu Tyr Trp Tyr Arg
705 710 715 720
Asn Leu Arg Glu Pro Val Gly Phe Gly Ala Thr Ile Glu Leu Leu Gln
725 730 735
Thr Gln Gly Asp Thr Ile Phe Ile Glu Val Ser Ala Ser Pro Val Leu
740 745 750
Leu Gln Ala Ile Asp Asp Ser Ile Ala Ile Pro Thr Leu Arg Arg Asp
755 760 765
Asp Gly Thr Pro Thr Arg Leu Leu Thr Ala Leu Ala Glu Ala His Val
770 775 780
Asn Gly Val Thr Ile Asp Trp Ala Thr Val Leu Gly Ala Thr Gly Ser
785 790 795 800
Pro Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Phe Trp Val
805 810 815
Gly Asp Arg Leu His Gly Arg Thr Ser Ala Glu Gln His Arg Ile Met
820 825 830
Leu Asp Leu Val Leu Gly His Ala Thr Ser Val Leu Gly His Gln Thr
835 840 845
Pro Asp Ala Val Ala Ser Asp Arg Ala Phe Lys Asp Leu Gly Met Asp
850 855 860
Ser Leu Thr Ala Val Glu Leu Arg Asn His Leu Val Ala Glu Thr Gly
865 870 875 880
Leu Arg Leu Pro Ala Thr Thr Ala Phe Asp His Pro Thr Ala Asp Asp
885 890 895
Leu Ala Arg Arg Leu
900
<210> 128
<211> 948
<212> PRT
<213> Actinoplanes sp.
<400> 128
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Ala Pro Gly Cys Val
1 5 10 15
Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ala Asp Phe Pro Ala Asp Arg Gly Trp Asp Leu Ala Thr Leu Tyr
35 40 45
Ser Pro Asp Pro Ile Gly Tyr Thr Ser Tyr Cys Leu Gln Gly Gly Phe
50 55 60
Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr
85 90 95
Ser Trp Glu Ala Ile Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu Arg
100 105 110
Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Thr Gln Gly Tyr Gly
115 120 125
Val Gly Ala Val Asp Gln Gln Arg Asp Asn Val Ile Thr Gly Ser Ser
130 135 140
Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Met Ala Leu
180 185 190
Val Ser Gly Val Ser Val Ile Pro Thr Pro Asp Val Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ser Phe Ser
210 215 220
Ala Ala Ala Asp Gly Thr Ile Trp Ala Glu Gly Val Gly Val Leu Val
225 230 235 240
Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Glu Val Leu Ala
245 250 255
Val Ile Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Ala Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
275 280 285
Ala Ser Ala Gly Leu Asn Ala Ala Asp Val Asp Thr Val Glu Ala His
290 295 300
Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Ser Ser Pro Val Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Ser Met Ala Ala Ser Gly Val Leu Gly Val
340 345 350
Ile Lys Met Val Glu Ala Met Arg His Ala Arg Leu Pro Arg Thr Leu
355 360 365
His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ser Gly Asp Val
370 375 380
Ala Leu Leu Thr Glu Asn Gln Pro Trp Pro Asp Gly Ala Arg Pro Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val
405 410 415
Val Leu Glu Gln His Arg Ala Pro Ala Val Pro Val Ala Ala Glu Thr
420 425 430
Val Ala Asp Asp Val Pro Leu Pro Leu Leu Leu Ser Ala Arg His Pro
435 440 445
Lys Ala Leu Arg Asp Gln Ala Ala Arg Leu His Ala Ala Leu Ala Glu
450 455 460
Ala Pro Gly Trp Arg Pro Leu Asp Val Gly Tyr Ser Leu Ala Thr Thr
465 470 475 480
Arg Ser Ala Phe Ala His Arg Ala Val Ala Val Gly Ser Gly Arg Glu
485 490 495
Leu Leu Arg Ala Leu Ala Lys Leu Ala Glu Gly Ala Ala Trp Pro Ala
500 505 510
Leu Val Thr Gly Thr Ala Lys Ala Gly Arg Val Ala Phe Leu Phe Asp
515 520 525
Gly Gln Gly Thr Gln Arg Leu Gly Met Gly Arg Val Leu His Asp Arg
530 535 540
Phe Pro Val Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Arg Phe Asp
545 550 555 560
Gln His Leu Asp His Ser Leu Thr Asp Val Tyr Leu Gly Arg Asp Thr
565 570 575
Ser Ala Ala Ala Leu Ala Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile
580 585 590
Phe Thr Met Glu Val Ala Leu Phe Glu Leu Leu Ala Glu Trp Gly Val
595 600 605
Arg Pro Asp Leu Val Ser Gly His Ser Ile Gly Glu Val Ala Ala Ala
610 615 620
Tyr Ala Ala Gly Leu Phe Ser Leu Glu Asp Ala Ala Thr Leu Ile Val
625 630 635 640
Ala Arg Gly Arg Ala Leu Arg Gln Met Pro Pro Gly Ala Met Leu Ala
645 650 655
Leu Arg Ala Ser Glu Asp Gln Val Arg Glu Leu Leu Asp Arg Thr Gly
660 665 670
Ala Asp Leu Asp Val Ala Ala Val Asn Ser Pro Val Ser Val Val Val
675 680 685
Ser Gly Asp Pro Asp Ala Val Ala Ala Phe Arg Ala Glu Trp Glu Ala
690 695 700
Ser Glu Arg Asp Ala Arg Ala Leu Asn Val His His Ala Phe His Ser
705 710 715 720
Arg Arg Val Asp Ala Val Leu Asp Glu Phe Arg Ala Val Leu Gly Thr
725 730 735
Leu Thr Phe Arg Thr Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly
740 745 750
Arg Leu Ala Gly Pro Ala Glu Met Ser Thr Pro Glu Tyr Trp Leu Arg
755 760 765
Gln Ile Arg Arg Thr Val Arg Phe Gln Asp Ala Val Arg Glu Leu Ser
770 775 780
Gly Gln Gly Ala Gly Thr Phe Val Glu Ile Gly Pro Ser Gly Ala Leu
785 790 795 800
Ala Ala Ala Gly Leu Glu Cys Val Asp Ala Ser Phe His Ala Val Gln
805 810 815
Arg Pro Arg Ser Pro Glu Asp Ala Cys Leu Leu Thr Ala Val Ala Glu
820 825 830
Leu His Ala Gly Gly Thr Ala Val Asp Trp Ala Lys Val Leu Ala Gly
835 840 845
Gly Arg Ala Thr Asp Leu Pro Val Tyr Pro Phe Gln His Glu Thr Tyr
850 855 860
Trp Ile Pro Pro Ala Ser Pro Pro Ala Asp Thr Arg Thr Met Leu Glu
865 870 875 880
Val Val His Glu Glu Ala Ala Leu Val Leu Gly Val Thr Asp Pro Arg
885 890 895
Val Ile Leu Asp Asp Ser Ser Phe Leu Asp Leu Gly Phe Asp Ser Leu
900 905 910
Ser Ala Met Arg Leu Gly Asn Gln Leu Ser Ala Val Thr Gly Leu Asp
915 920 925
Leu Pro Pro Ser Leu Leu Phe Glu His Pro Thr Val Gly Glu Leu Ala
930 935 940
Ala His Leu Asp
945
<210> 129
<211> 886
<212> PRT
<213> Actinoplanes sp.
<400> 129
Glu Pro Leu Ala Ile Val Gly Met Ala Ala Arg Phe Pro Gly Gly Val
1 5 10 15
Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Val Ser Gly Gly Asp Ala
20 25 30
Ile Gly Gly Phe Pro Ala Asp Arg Gly Trp Asp Leu Glu Glu Leu Tyr
35 40 45
Asp Pro Asp Pro Ala Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Asn Asp Ala Thr Thr Phe Asp Ala Ser Phe Phe Arg Ile Gly
65 70 75 80
Pro Arg Glu Ala Lys Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Arg Pro Glu Thr Leu
100 105 110
Arg Gly Thr Ala Thr Gly Val Phe Ala Gly Ile Ser Leu Gln Asp Tyr
115 120 125
Gly Val Leu Ala Gly Ser Asp Pro Glu Leu Glu Gly Tyr Ala Gly Thr
130 135 140
Gly Asn Ala Pro Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly
145 150 155 160
Leu Glu Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Arg Asp Glu Cys Thr
180 185 190
Leu Ala Val Val Gly Gly Val Thr Val Met Pro Ser Pro Asn Val Phe
195 200 205
Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys
210 215 220
Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Lys Arg Arg
245 250 255
Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Ser Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg
275 280 285
Ser Ala Leu Ala Ala Ala Gly Leu Thr Ala Gly Asp Val Asp Val Val
290 295 300
Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Gly Val Leu Ala Thr Tyr Gly Asp Arg Ser Gly Ala Pro Val Arg Leu
325 330 335
Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Ile
340 345 350
Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg His Gly Val Met Pro
355 360 365
Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp Thr Ala
370 375 380
Gly Arg Val Glu Leu Leu Thr Ser Asn Leu Pro Trp Pro Thr Ser Glu
385 390 395 400
Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn
405 410 415
Ala His Val Ile Leu Glu Gln Ala Phe Pro Ala Thr Glu Pro Glu Pro
420 425 430
Ser Phe Thr Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser
435 440 445
Ala Arg Asp Ser Gly Ala Leu Ala Thr Arg Thr His Leu Ser Asp Gly
450 455 460
Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His
465 470 475 480
Arg Ser Val Arg Ile Gly Asp Met Thr Val Thr Gly Val Ala Thr Thr
485 490 495
Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala
500 505 510
Gly Met Gly Arg Ala Leu Met Asp Ala Ser Pro Val Phe Ala Glu Arg
515 520 525
Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp Glu
530 535 540
Ala Ile Asp Thr Pro Asp Gln Val Glu Thr Leu Gln Pro Ala Ser Trp
545 550 555 560
Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg
565 570 575
Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
580 585 590
Val Ala Gly Ser Leu Ser Leu Ala Asp Ala Ala Ala Val Val Ala Leu
595 600 605
Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala Ser
610 615 620
Ile Pro Leu Pro Val Glu Glu Ile Glu Leu Ile Asp Glu Val Trp Val
625 630 635 640
Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Pro Asp
645 650 655
Ala Val Glu Gln Val Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala Val
660 665 670
Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val
675 680 685
Val Ser Val Pro Ser Gln Ala Pro Asp Ile Pro Trp Phe Ser Thr Val
690 695 700
Asp Ser Glu Trp Val Glu Gly Pro Leu Asp Asp Asp Tyr Trp Phe Arg
705 710 715 720
Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Arg Phe Asp
725 730 735
Asp Ala Val Phe Val Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala
740 745 750
Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly
755 760 765
Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val
770 775 780
Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro Phe Val Asp Leu
785 790 795 800
Pro Thr Tyr Pro Phe Gln Gly Glu Arg Phe Trp Ile Asp Leu Asp Asp
805 810 815
Val Leu Ala Val Val Arg Asp Cys Ala Ala Thr Val Leu Gly His Thr
820 825 830
Asp Pro Ala Ala Ile Ala Pro Asp Arg Pro Phe Lys Asp Leu Gly Phe
835 840 845
Asp Ser Leu Ala Ala Val Gln Leu Arg Asn His Leu Leu Thr Val Thr
850 855 860
Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro Thr Pro Ala
865 870 875 880
Val Leu Ala Gly Glu Val
885
<210> 130
<211> 859
<212> PRT
<213> Actinoplanes sp.
<400> 130
Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala
20 25 30
Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Glu Leu Gly Glu Ala Ala
35 40 45
Tyr Ala Arg Val Gly Gly Phe Val Thr Gly Ala Thr Gly Phe Asp Ala
50 55 60
Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln
65 70 75 80
Gln Arg Leu Leu Leu Glu Val Ala Trp Glu Ala Phe Glu Arg Ala Gly
85 90 95
Ile Ala Pro Asp Ala Leu Arg Gly Ser Asp Thr Gly Val Phe Val Gly
100 105 110
Thr Tyr Gly Gln Gly Tyr Gly Glu Leu Ala Val Asp Gly Asp Ala Glu
115 120 125
Gly Tyr Val Gly Ile Gly Asn Ser Gly Ser Val Val Ser Gly Arg Val
130 135 140
Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala
145 150 155 160
Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg
165 170 175
Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser
180 185 190
Ser Pro Leu Ile Phe Gln Glu Phe Ala Arg Gln Gly Gly Leu Ala Ala
195 200 205
Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp
210 215 220
Gly Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Gln
225 230 235 240
Arg Arg Gly His Thr Val Leu Ala Val Val Arg Gly Ser Ala Val Asn
245 250 255
Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln
260 265 270
Gln Arg Val Ile Arg Ser Ala Leu Ala Ser Ala Gly Leu Gly Phe Gly
275 280 285
Asp Val Asp Leu Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp
290 295 300
Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly Ser Ala Gly Thr
305 310 315 320
Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala
325 330 335
Ala Ala Gly Val Ala Gly Val Ile Lys Ala Val Glu Ala Met Arg His
340 345 350
Gly Val Leu Pro Gln Thr Leu His Ala Asp Gln Pro Ser Ser His Val
355 360 365
Asp Trp Thr Ala Gly Ala Val Glu Leu Leu Thr Ala Asn Arg Pro Trp
370 375 380
Asp Ser Ala Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile
385 390 395 400
Ser Gly Thr Asn Ala His Val Ile Leu Glu Glu Phe Ser Ser Ala Pro
405 410 415
Val Ser Pro Glu Pro Gly Ala Gly Ala Ala Pro Leu Leu Leu Ser Ala
420 425 430
Arg Ser Ala Ala Ala Leu Ala Glu Phe Glu Ser Arg Val Ala Ala Leu
435 440 445
Arg Pro Ser Arg Asp Leu Ala Ala Thr Leu Ala Gly Arg Val Phe Phe
450 455 460
Asp His Arg Ala Val Val Leu Pro Gly Gly Glu Val Val Arg Gly Arg
465 470 475 480
Val Gly Asp Ala Pro Val Val Phe Val Phe Ala Gly Gln Gly Ser Gln
485 490 495
Arg Ser Asp Met Ala Ser Arg Leu Ala Gly Glu Phe Pro Leu Phe Ala
500 505 510
Ala Ala His Glu Arg Val Trp Ser Leu Leu Asp Val Asp Glu Ser Leu
515 520 525
Asp Val Asp Gln Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Tyr Glu
530 535 540
Val Ala Leu Ala Glu Leu Leu Gly Val Arg Pro Asp Ala Val Ile Gly
545 550 555 560
His Ser Val Gly Glu Leu Ala Ala Ala Tyr Val Ala Gly Ala Leu Ser
565 570 575
Leu Glu Asp Ala Cys Arg Leu Val Ser Ala Arg Ala Arg Leu Met Gln
580 585 590
Ala Leu Pro Pro Gly Gly Val Met Val Ser Val Arg Val Ser Glu Glu
595 600 605
Ala Ala Arg Ala Val Leu Arg Asp Gly Val Glu Leu Ala Ala Val Asn
610 615 620
Gly Pro Arg Ala Val Val Leu Ser Gly Asp Glu Gly Ala Val Leu Ala
625 630 635 640
Ala Ala Ala Glu Leu Gly Glu Phe Arg Arg Leu Arg Thr Ser His Ala
645 650 655
Phe His Ser Ala Leu Met Glu Pro Met Leu Glu Glu Phe Arg Ala Val
660 665 670
Ala Ser Ser Val Glu Phe Gly Glu Pro Glu Ile Ala Leu Ser Phe Val
675 680 685
Pro Ser Ala Asp Tyr Phe Val Arg Gln Val Arg Glu Thr Val Arg Phe
690 695 700
Gly Glu Gln Val Ala Ala Phe Glu Pro Gly Thr Leu Phe Val Glu Val
705 710 715 720
Gly Pro Asp Gly Ser Leu Ser Arg Leu Thr Gly Gly Val Asn Ala Ala
725 730 735
Glu Pro Leu Thr Ala Leu Ala His Leu Trp Ala His Gly Ala Val Val
740 745 750
Asp Trp Thr Pro Tyr Thr Ser Asp Gly Arg Leu Asp Thr Ala Pro Thr
755 760 765
Tyr Pro Phe Gln Pro Glu Arg Tyr Trp Pro Glu Gln Arg Arg Arg Arg
770 775 780
Ala Arg Arg Gly Asp Ser Leu Ala Leu Val Ile Ala Thr Ala Ala Ala
785 790 795 800
Val Leu Gly His Pro Glu Gly Thr Asp Ile Pro Ala Asp Thr Pro Phe
805 810 815
Gln Ser Leu Gly Phe Asp Ser Leu Ser Ala Val Asp Leu Arg Asn Gln
820 825 830
Leu Ala His Ala Thr Gly Val Arg Leu Ser Pro Thr Ala Val Phe Asp
835 840 845
His Pro Thr Pro Arg Ala Leu Ala Glu Arg Leu
850 855
<210> 131
<211> 899
<212> PRT
<213> Actinoplanes sp.
<400> 131
Asp Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val
1 5 10 15
Ala Thr Ala Asp Asp Leu Trp Asp Leu Val Ala Glu Gly Gly Asp Ala
20 25 30
Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asp Leu Ala Gly Leu Tyr
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Gly Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ala Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Leu Asp Leu
100 105 110
Arg Arg Ser Asp Thr Gly Val Phe Val Gly Thr Met Ala Gln Glu Tyr
115 120 125
Gly Gly Leu Val Thr Asp Ser Ala His Gly Leu Glu Gly Trp Ile Gly
130 135 140
Thr Gly Asn Ser Gln Ser Val Met Ser Gly Arg Leu Ser Tyr Phe Phe
145 150 155 160
Gly Leu Gln Gly Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser
165 170 175
Leu Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Ser Gly Glu Cys
180 185 190
Ser Leu Ala Val Val Gly Gly Val Thr Val Met Ser Ser Pro Arg Thr
195 200 205
Phe Gln Glu Phe Ser Arg Gln Arg Gly Met Ala Pro Asp Gly Arg Cys
210 215 220
Lys Pro Phe Ala Ala Ala Ala Asp Gly Thr Gly Trp Ser Glu Gly Val
225 230 235 240
Gly Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Asn Gly His
245 250 255
Ala Val Leu Ala Val Val Arg Gly Thr Ala Val Asn Gln Asp Gly Thr
260 265 270
Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Gln Val Ile
275 280 285
Arg Ala Ala Leu Glu Arg Ala Gly Leu Gly Val Gly Asp Val Asp Val
290 295 300
Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala
305 310 315 320
Gln Ala Ile Leu Asp Thr Tyr Gly Ser Arg Thr Thr Gly Glu Pro Val
325 330 335
Arg Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala
340 345 350
Gly Val Ala Gly Val Ile Lys Met Val Gln Ala Met Arg His Ala Thr
355 360 365
Met Pro Arg Ser Leu His Ile Asp Glu Pro Ser Pro His Val Asp Trp
370 375 380
Ala Ser Gly Ala Val Glu Leu Leu Thr Ala Glu Arg Gly Trp Pro Ala
385 390 395 400
Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly
405 410 415
Thr Asn Ala His Val Ile Val Glu Gly Val Thr Glu Pro Glu Pro Ser
420 425 430
Arg Glu Ala Ala Pro Ser Gly Pro Leu Pro Leu Met Leu Ser Ala Pro
435 440 445
Thr Ala Glu Ala Leu Ala Glu Gln Glu Thr Arg Leu Arg Arg Phe Arg
450 455 460
Ala Asp Arg Pro Asp Ala Asp Glu Arg Asp Ile Ala Val Thr Leu Ala
465 470 475 480
Gly Arg Thr Gly Phe Ala His Arg Thr Val Leu Ile Gly Glu Leu Ser
485 490 495
Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val Phe Val Phe Pro
500 505 510
Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Asp Leu Met Asp Ala
515 520 525
Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala Ala Ala Leu Glu
530 535 540
Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Thr Pro Asp Arg Val Glu
545 550 555 560
Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu Ala Ala Val
565 570 575
Trp Gln Ala Ala Gly Val Arg Pro Ala Ala Val Ile Gly His Ser Gln
580 585 590
Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Leu Ser Leu Ala Asp
595 600 605
Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu
610 615 620
Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Ala Glu Glu Ile Glu
625 630 635 640
Leu Ile Asp Glu Val Trp Val Ala Ala Leu Asn Gly Pro Ser Ser Thr
645 650 655
Val Val Ala Gly Ala Pro Asp Ala Val Glu Gln Val Arg Ala Arg Tyr
660 665 670
Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val
675 680 685
Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser Gln Ala Pro Asp
690 695 700
Ile Pro Trp Phe Ser Thr Val Asp Ser Gly Trp Val Glu Gly Pro Leu
705 710 715 720
Asp Asp Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro Val Gln Phe Gly
725 730 735
Pro Ala Ala Ala Arg Phe Asp Asp Ala Val Phe Ile Glu Val Ser Ala
740 745 750
Arg Pro Val Leu Ile Pro Val Leu Glu Asp Ala Val Thr Val Pro Thr
755 760 765
Leu Arg Arg Asp Asp Gly Gly Ile Gly Arg Leu His Ala Ser Val Ala
770 775 780
Gln Ala Trp Thr Ala Gly Ala Asp Val Asp Trp Ala Ala Leu Leu Pro
785 790 795 800
Ala Gly Gly Arg Arg Ile Ala Leu Pro Pro Tyr Ala Phe Thr His Glu
805 810 815
Arg Phe Trp Pro Arg Arg Pro Ala Ala Ala Gly Gln Asp Leu Leu Thr
820 825 830
Val Val Arg Thr Ala Ala Ala Thr Val Leu Gly His Arg Asp Ala Ala
835 840 845
Arg Val Pro Ala Asp Arg Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu
850 855 860
Ser Ala Val Gln Leu Arg Asn Glu Leu Leu Thr Ala Thr Gly Val Arg
865 870 875 880
Leu Ser Ala Thr Ala Val Phe Asp His Pro Thr Ala Ala Ala Leu Ala
885 890 895
Glu Ala Leu
<210> 132
<211> 873
<212> PRT
<213> Actinoplanes sp.
<400> 132
Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ser Ser Pro Asp Glu Leu Trp Glu Leu Val Glu Ser Gly Arg Asp Ala
20 25 30
Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Ser Thr Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ala Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Tyr Val Gly Thr Tyr Ala Gln Gly Tyr
115 120 125
Gly Glu Leu Ala Ala Ala Thr Ala Gly Glu Gly Phe Val Gly Ile Gly
130 135 140
Asn Ser Gly Ser Val Val Ser Gly Arg Val Ser Tyr Phe Leu Gly Leu
145 150 155 160
Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val
165 170 175
Ala Leu His Gln Ala Ala Gln Ala Leu Arg Leu Gly Glu Cys Ser Leu
180 185 190
Ala Leu Val Gly Gly Val Thr Val Met Ala Ser Pro Leu Met Phe Gln
195 200 205
Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys Lys Ala
210 215 220
Phe Ala Glu Gly Ala Asp Gly Thr Gly Trp Gly Glu Gly Ala Gly Val
225 230 235 240
Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr Val
245 250 255
Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn
260 265 270
Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala
275 280 285
Ala Leu Ala Ala Ala Gly Leu Thr Phe Gly Asp Val Asp Val Val Glu
290 295 300
Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln Ala
305 310 315 320
Leu Leu Ala Thr Tyr Gly Ala Ala Gly Ser Pro Val Arg Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly
340 345 350
Val Ile Lys Met Val Gln Ala Met Arg His Gly Val Met Pro Arg Thr
355 360 365
Leu His Val Asp Gln Pro Ser Ser His Val Asp Trp Ser Ala Gly Ala
370 375 380
Val Glu Leu Leu Thr Ala Asn Arg Thr Trp Glu Ala Pro Gly Arg Pro
385 390 395 400
Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
405 410 415
Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Ala Gly Ser Ala
420 425 430
Glu Thr Ala Pro Leu Leu Leu Ser Ala Arg Thr Val Pro Ala Leu Asn
435 440 445
Asp Phe Glu Ala Arg Val Ser Ala Arg Pro Ser Ser Pro Asp Leu Ala
450 455 460
Ala Thr Leu Ser Arg Arg Val Phe Phe Asp His Arg Ala Val Val Leu
465 470 475 480
Pro Gly Gly Glu Val Val Arg Gly Arg Val Gly Asp Ala Pro Val Val
485 490 495
Phe Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg
500 505 510
Leu Ala Gly Glu Phe Pro Val Phe Ala Ala Ala His Glu Arg Val Trp
515 520 525
Ser Leu Leu Asp Val Asp Glu Gly Leu Ala Val Asp Gln Thr Gly Leu
530 535 540
Ala Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu
545 550 555 560
Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu Ala
565 570 575
Ala Ala Tyr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Cys Arg Leu
580 585 590
Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val
595 600 605
Met Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu Arg
610 615 620
Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Arg Ala Val Val Leu
625 630 635 640
Ser Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly Glu
645 650 655
Phe Arg Arg Leu Arg Thr Ser His Ala Phe His Ser Ala Arg Met Glu
660 665 670
Pro Met Leu Glu Glu Phe Arg Ala Val Ala Ser Ser Val Val Phe Gly
675 680 685
Glu Pro Glu Ile Ala Met Ser Phe Val Pro Ser Ala Asp Tyr Phe Val
690 695 700
Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe
705 710 715 720
Asp Pro Gly Ser Leu Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser
725 730 735
Arg Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Met Lys Ala Leu Ala
740 745 750
Tyr Leu Trp Val Arg Gly Val Gly Val Asp Trp Ala Pro Tyr Val Gly
755 760 765
Gly Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln Arg Glu
770 775 780
Gly Phe Trp Pro Thr Arg Glu Ala Leu Ala Gln Leu Pro Pro Ala Arg
785 790 795 800
Arg Gly Arg Ala Leu Leu Asp Leu Val Gln Asn Arg Val Ala Lys Thr
805 810 815
Leu Gly Leu Val Arg Pro Ala Asp Pro Gly Arg Ala Phe Thr Asp Leu
820 825 830
Gly Phe Thr Ser Leu Thr Ala Leu Glu Leu Arg Asn Ser Ile Ala Glu
835 840 845
Glu Thr Gly Leu Pro Leu Pro Ala Ser Leu Val Phe Asp His Pro Asn
850 855 860
Ala Arg Ala Leu Ala Ala Tyr Leu Asp
865 870
<210> 133
<211> 898
<212> PRT
<213> Actinoplanes sp.
<400> 133
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Ile
1 5 10 15
Ser Ser Ala Glu Glu Leu Trp Arg Leu Val Ala Glu Gly Gly Asp Ala
20 25 30
Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Asp Ile Asp Ala Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Thr Arg Ser Gly Gly
50 55 60
Phe Leu Pro Gly Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Gln Ala Met Asp Pro Gln His Arg Gln Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Leu Glu His Ala Gly Ile Asp Pro Ala Gly Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Phe Ala Gly Phe Ser Gly Gln Asp Tyr
115 120 125
Ile Ala Glu Met Gly Val Gly Pro Ala Glu Ala Gly Gly Tyr Gln Val
130 135 140
Thr Gly Arg Ala Ala Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr
145 150 155 160
Gly Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser
165 170 175
Leu Val Ala Leu His Leu Ala Gly Gln Ser Leu Arg Asp Gly Glu Ser
180 185 190
Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Ser Ser Pro Gly Leu
195 200 205
Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys
210 215 220
Lys Ala Phe Ser Val Asp Ala Asp Gly Thr Gly Trp Ser Glu Gly Val
225 230 235 240
Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His
245 250 255
Gln Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala
260 265 270
Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile
275 280 285
Arg Gln Ala Leu Ala Gln Ser Gly Leu Ser Val Gly Asp Val Asp Val
290 295 300
Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala
305 310 315 320
Gln Ala Val Leu Ala Thr Tyr Gly Ser Arg Thr Gly Gly Glu Pro Val
325 330 335
Arg Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala
340 345 350
Gly Ile Ala Ser Leu Ile Lys Met Val Gln Ser Ile Arg Tyr Gly Val
355 360 365
Met Pro Arg Thr Leu His Val Ser Glu Pro Ser Pro Leu Val Asp Trp
370 375 380
Ala Ala Gly Arg Val Glu Leu Leu Thr Ser Asp Val Pro Trp Pro Glu
385 390 395 400
Gly Val Arg Arg Ala Ala Val Ser Ala Phe Gly Ile Ser Gly Thr Asn
405 410 415
Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Glu Ala Val Pro
420 425 430
Ser Ile Arg Pro Val Val Ser Gly Pro Glu Leu Pro Leu Val Phe Ser
435 440 445
Ala Arg Asp Ala Asp Ala Leu Ala Ala Gln Ser Arg Leu Thr Asp Gly
450 455 460
Pro Gly Val Ala His Ala Leu Val Thr Ala Arg Thr Val Phe Asp His
465 470 475 480
Arg Ser Val Arg Met Gly Asp Val Thr Val Thr Gly Val Ala Thr Pro
485 490 495
Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Pro
500 505 510
Gly Met Gly Arg Asp Leu Met Ala Ala Ser Pro Val Phe Ala Asp Arg
515 520 525
Met Asn Glu Cys Ala Leu Ala Leu Ser Pro Tyr Leu Asp Leu Trp Ala
530 535 540
Ala Ile Asp Ala Pro Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp
545 550 555 560
Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Gln
565 570 575
Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys
580 585 590
Val Ala Gly Ser Leu Ser Leu Ala Asp Ala Ala Ala Val Val Ala Leu
595 600 605
Arg Ser Arg Ala Ile Ala Ser Leu Ala Gly Lys Gly Ala Met Ala Ser
610 615 620
Ile Pro Leu Pro Ala Glu Glu Ile Glu Leu Val Asp Glu Val Trp Val
625 630 635 640
Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Thr Pro Asp
645 650 655
Ala Val Glu Gln Ile Arg Ser Arg Tyr Asp Gly Arg Arg Ile Ala Val
660 665 670
Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln Val
675 680 685
Val Ser Val Pro Ser Gln Ser Pro Ala Val Pro Trp Phe Ser Thr Val
690 695 700
Asp Ser Ala Trp Val Glu Gly Pro Leu Asp Glu Asp Tyr Trp Phe Arg
705 710 715 720
Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Gly Phe Asp
725 730 735
Asn Ala Val Phe Val Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala
740 745 750
Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly
755 760 765
Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val
770 775 780
Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro His Val Asp Leu
785 790 795 800
Pro Thr Tyr Pro Phe Arg Arg Gln Arg His Trp Ile Asp Met Glu Arg
805 810 815
Leu Gly Gln Leu Pro Pro Gly Asp Arg Asp Arg Phe Leu Leu Asp Leu
820 825 830
Val Arg Asp Ala Ala Ala Ala Val Leu Gly His Gly Ser Arg Glu Thr
835 840 845
Val Pro Ala Ser Ala Ala Phe Lys Glu Leu Gly Phe Asp Ser Leu Ile
850 855 860
Ala Val Gln Leu Arg Asn Ala Val Ala Ala Ala Thr Gly Val Ser Leu
865 870 875 880
Pro Ala Thr Val Thr Phe Asp His Pro Thr Pro Gln Ala Leu Ala Val
885 890 895
Leu Leu
<210> 134
<211> 920
<212> PRT
<213> Actinoplanes sp.
<400> 134
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Lys Phe Pro Gly Gly Val
1 5 10 15
Asp Ser Pro Glu Arg Leu Trp Glu Met Val Glu Ala Gly Glu Asp Val
20 25 30
Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Asp Val Asp Gly Gly Tyr
35 40 45
Asp Pro Asp Pro Glu Lys Ala Gly Ser Trp Tyr Ala Arg Ala Gly Gly
50 55 60
Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Asn
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ser Gly Ile Ala Pro Asp Ser Leu
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Val Gly Thr Phe Gly Gln Gly Tyr
115 120 125
Gly Arg Leu Val Ala Ala Gly Ala Pro Gly Leu Glu Ala Tyr Ser Gly
130 135 140
Thr Gly Asn Thr Gly Ser Val Ala Ser Gly Arg Leu Ser Tyr Val Phe
145 150 155 160
Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser
165 170 175
Leu Val Ala Leu His Gln Ala Gly Arg Ser Leu Gln Ser Gly Glu Cys
180 185 190
Ser Leu Ala Leu Val Ala Gly Val Thr Val Met Ser Thr Pro Asp Ser
195 200 205
Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ser Pro Asp Gly Arg Cys
210 215 220
Lys Ala Phe Ala Ala Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly Ala
225 230 235 240
Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His
245 250 255
Gln Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala
260 265 270
Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile
275 280 285
Thr Ala Ala Leu Thr Asp Ala Arg Leu Thr Thr Thr Asp Ile Asp Leu
290 295 300
Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala
305 310 315 320
Gln Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val
325 330 335
His Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala
340 345 350
Gly Ile Ala Gly Val Ile Lys Ala Ile Gln Ala Ile Arg His Thr Thr
355 360 365
Met Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp
370 375 380
Thr Ser Gly Arg Val Glu Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala
385 390 395 400
Thr Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly
405 410 415
Thr Asn Ala His Val Ile Leu Glu Glu Gln Thr Pro Val Glu Glu Pro
420 425 430
Pro Pro Ala Ser Ala Gly Pro Val Pro Leu Ala Leu Ser Ala Arg Thr
435 440 445
Pro Glu Ala Leu Thr Ala Gln Glu Lys Ala Val Arg Gly Leu Pro Asp
450 455 460
Gly Asp Arg Arg Arg Ala Ala Pro Ala Leu Ala Leu Gly Arg Ala Ala
465 470 475 480
Leu Pro His Arg Ala Val Leu Leu Gly Asp Ser Val Ile Arg Gly Thr
485 490 495
Ala Ser Ala Asp Asp Gly Arg Pro Val Phe Leu Phe Pro Gly Gln Gly
500 505 510
Ala Gln Trp Ala Gly Met Gly Arg Glu Leu Met Ala Ala Ser Pro Val
515 520 525
Phe Ala Glu Arg Met Arg Glu Cys Ala Val Ala Leu Ala Gly Phe Val
530 535 540
Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Ala Glu Ala Leu Arg Arg
545 550 555 560
Thr Glu Ile Val Gln Pro Ala Ser Trp Ala Met Met Val Ser Leu Ala
565 570 575
Ala Leu Trp Glu Ser Trp Gly Val Arg Pro Ala Ala Val Val Gly His
580 585 590
Ser Gln Gly Glu Thr Ala Ala Ala Val Val Ala Gly Ala Ile Gly Leu
595 600 605
Arg Asp Gly Ala Arg Leu Ser Ala Thr Arg Ser Arg Val Leu Ala Leu
610 615 620
Leu Ala Gly His Gly Ala Leu Ala Ser Ile Ala Leu Pro Ala Gly Glu
625 630 635 640
Val Glu Val Val Asp Gly Val Ser Val Ala Ala Val Asn Gly Pro Arg
645 650 655
Ala Thr Leu Ile Ser Gly Asp Pro Ala Gly Val Glu Ala Val Thr Ala
660 665 670
Arg Tyr Glu Ala Ser Gly Val Arg Val Arg Arg Ile Pro Ala Asp Val
675 680 685
Ala Ser His Ser Pro His Val Glu Arg Ala Glu Glu Thr Leu Leu Ala
690 695 700
Ala Leu Ala Gly Ile Glu Ala Arg Val Pro Gly Val Pro Trp Leu Ser
705 710 715 720
Thr Ala Thr Gly Asp Trp Ile Thr Glu Pro Val Asp Glu Arg Tyr Trp
725 730 735
Tyr Arg Asn Leu Arg Ser Pro Val Leu Phe His Pro Ala Ile Thr Thr
740 745 750
Leu Arg Asp Arg Gly His Arg Leu Phe Leu Glu Ile Ser Thr His Pro
755 760 765
Gln Leu Leu Pro Ala Met Glu Asp Asp Leu Leu Thr Val Gly Ser Leu
770 775 780
Arg Arg Asp Asp Gly Asp Leu Asp Arg Met His Ala Ala Leu Ala Glu
785 790 795 800
Ala Trp Ala Ala Gly Ala Asp Val Asp Trp Arg Ala Phe Leu Gly Ser
805 810 815
Gly Pro Val Arg Ala Leu Asp Leu Pro Thr Tyr Pro Phe Gln Arg Arg
820 825 830
Arg Phe Trp Pro Glu Ala Gly Ala Leu Pro Pro Ala Glu Arg Glu Arg
835 840 845
Ala Leu Val Glu Ile Val Arg Asp Gln Ala Ala Ala Val Leu Gly Asp
850 855 860
Pro Asp Ala Gly Ala Leu Thr Pro Gly Thr Ala Phe Arg Asp Leu Gly
865 870 875 880
Phe Asp Ser Leu Thr Ala Val Gln Leu Arg Asn His Leu Ala Thr Ala
885 890 895
Thr Gly Leu Thr Leu Pro Ala Thr Val Ile Phe Asp His Pro Thr Pro
900 905 910
Arg Ala Leu Ala Thr Phe Leu Asp
915 920
<210> 135
<211> 883
<212> PRT
<213> Actinoplanes sp.
<400> 135
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Asp Gln Leu Trp Asp Leu Val Val Ser Gly Gly Asp Gly
20 25 30
Ile Gly Pro Phe Pro Gly Asp Arg Gly Trp Ala Thr Asp Glu Ile Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ser Gly Lys Thr Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Asp Ser Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Ser Trp Glu Ala Phe Glu His Ala Gly Ile Asp Pro Ala Gly Leu
100 105 110
Arg Gly Gly Asp Thr Gly Val Phe Val Gly Gly Phe Thr Gln Ala Tyr
115 120 125
Gly Val Gly Thr Ala Asp Leu Glu Gly Tyr Ala Ala Thr Gly Thr Val
130 135 140
Gly Ser Val Leu Ser Gly Arg Leu Ser Tyr Phe Tyr Gly Phe Glu Gly
145 150 155 160
Pro Ala Val Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Gln Ala Gly Gln Ala Leu Arg Gln Gly Glu Cys Thr Leu Ala Val
180 185 190
Val Gly Gly Val Thr Val Met Pro Thr Pro Val Val Phe Gln Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala
210 215 220
Asp Glu Ala Asp Gly Thr Gly Phe Ala Glu Gly Ala Gly Val Leu Leu
225 230 235 240
Val Cys Arg Leu Ser Asp Ala Arg Arg Asp Gly Arg Arg Ile Leu Ala
245 250 255
Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu
275 280 285
Ala Ser Ala Arg Leu Gly Pro Gly Asp Val Asp Leu Ile Glu Gly His
290 295 300
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu
305 310 315 320
Ala Thr His Gly Ser Gly Ala Ser Pro Val Arg Leu Gly Ser Leu Lys
325 330 335
Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile
340 345 350
Lys Val Ile Gln Ala Leu Arg His Gly Leu Met Pro Arg Thr Leu His
355 360 365
Val Gly Thr Pro Ser Ser Gln Val Asp Trp Ser Ala Gly Asn Val Glu
370 375 380
Leu Leu Thr Ser Asn Leu Pro Trp Pro Ala Thr Asp Arg Pro Arg Arg
385 390 395 400
Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Glu Ala Pro Ala Pro Ala Ala Val Pro Ser Ile Thr Pro Val
420 425 430
Val Ser Gly Pro Ala Leu Pro Leu Val Phe Ser Ala Arg Asp Ser Gly
435 440 445
Ala Leu Ala Ala Arg Thr Arg Leu Thr Asp Gly Pro Gly Val Ala Phe
450 455 460
Ala Leu Ala Thr Ser Arg Ser Met Phe Asp His Arg Ala Val Arg Ile
465 470 475 480
Gly Asp Leu Ser Val Ser Gly Val Ala Val Ala Asp Arg Arg Val Val
485 490 495
Phe Val Phe Pro Gly Gln Gly Thr Gln Trp Ala Gly Met Gly Arg Ala
500 505 510
Leu Met Asp Ala Ser Pro Val Phe Ala Glu Arg Met Asn Glu Cys Ala
515 520 525
Ala Ala Leu Ser Pro Tyr Leu Asp Leu Trp Glu Ala Ile Asp Ala Pro
530 535 540
Asp Arg Val Glu Thr Leu Gln Pro Ala Ser Trp Ala Val Met Val Ser
545 550 555 560
Leu Ala Ala Val Trp Gln Ala Val Gly Val Glu Pro Ala Ala Val Ile
565 570 575
Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ser Ile
580 585 590
Ser Leu Pro Asp Ala Ala Ala Val Val Ala Leu Arg Ser Lys Ala Ile
595 600 605
Ala Ser Leu Ala Gly Lys Gly Ala Met Ala Ser Ile Pro Leu Pro Pro
610 615 620
Asp Gln Ile Asp Leu Ile Asp Gln Val Trp Ile Ala Ala Leu Asn Gly
625 630 635 640
Pro Ser Ser Thr Val Val Ala Gly Ser Pro Glu Ala Val Glu Gln Val
645 650 655
Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala Val Asp Tyr Ala Ser His
660 665 670
Thr Pro His Val Glu Ala Leu Arg Gly Gln Val Val Ser Val Pro Ser
675 680 685
Gln Ala Pro Asp Ile Pro Trp Phe Ser Thr Val Asp Ser Ala Trp Val
690 695 700
Glu Lys Pro Leu Asp Gly Asp Tyr Trp Phe Arg Asn Leu Arg Gln Pro
705 710 715 720
Val Gln Phe Gly Pro Ala Ala Ala Arg Phe Asp Asp Ala Val Phe Ile
725 730 735
Glu Val Ser Ala Arg Pro Val Leu Ile Pro Ala Leu Asp Thr Ser Val
740 745 750
Thr Val Pro Ser Leu Arg Arg Asp Asp Gly Gly Pro Glu Arg Met Leu
755 760 765
Ala Ser Leu Ala Gln Ala Phe Val Ala Gly Val Ala Val Asp Trp Thr
770 775 780
Thr Ile Val Pro Pro Ala Pro Phe Val Glu Leu Pro Thr Tyr Pro Phe
785 790 795 800
Gln Arg Arg Arg Tyr Trp Ile Asp Ser Ser Glu Glu Ala Leu Arg Asp
805 810 815
Leu Val Arg Glu Gln Ala Ala Ala Val Leu Gly Tyr Pro Asp Pro Ser
820 825 830
Arg Ile Thr Pro Gly Val Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu
835 840 845
Thr Ala Val Gln Leu Arg Asn Ala Leu Ser Ala Ala Thr Gly Leu Arg
850 855 860
Leu Ser Ala Thr Val Ala Phe Asp His Pro Thr Pro Ala Ala Leu Ala
865 870 875 880
Ala Ala Leu
<210> 136
<211> 872
<212> PRT
<213> Actinoplanes sp.
<400> 136
Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ser Ser Pro Asp Glu Leu Trp Asp Leu Val Glu Ser Gly Arg Asp Ala
20 25 30
Ile Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Asp Glu Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Thr Gly Arg Ser Tyr Val Arg Glu Gly Gly
50 55 60
Phe Leu Ala Gly Ala Ala Asp Phe Asp Ala Glu Phe Phe Gly Ile Asn
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ala Trp Glu Ala Phe Glu Arg Ala Gly Ile Ala Pro Asp Ser Leu
100 105 110
Arg Gly Thr Asp Thr Gly Val Phe Leu Gly Ala Phe Ala Gly Gly Tyr
115 120 125
Leu Thr Leu Val Asn Gly Ala Ala Asp Leu Glu Gly Tyr Ala Gly Thr
130 135 140
Gly Asn Ser Val Ser Val Leu Ser Gly Arg Leu Ser Tyr Val Leu Gly
145 150 155 160
Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Gln Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser
180 185 190
Leu Ala Val Ala Gly Gly Val Thr Val Met Ser Thr Pro Asp Ser His
195 200 205
Val Glu Phe Ser Arg Gln Arg Ala Leu Ser Pro Asp Gly Arg Cys Arg
210 215 220
Ala Phe Ala Asp Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Glu Ala Arg Arg Arg Gly His Thr
245 250 255
Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg
275 280 285
Ser Ala Leu Ala Ser Ala Gly Leu Gly Phe Gly Asp Val Asp Leu Val
290 295 300
Glu Gly His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Ala Leu Leu Ala Thr Tyr Gly Ser Ala Gly Thr Pro Val Trp Leu Gly
325 330 335
Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala
340 345 350
Gly Val Ile Lys Ala Val Glu Ala Met Arg Arg Gly Val Met Pro Arg
355 360 365
Thr Leu His Val Asp Ala Pro Ser Ser His Val Glu Trp Ser Ser Gly
370 375 380
Ser Val Glu Leu Leu Thr Ala Asn Arg Pro Trp Asp Gly Val Gly Arg
385 390 395 400
Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala
405 410 415
His Val Ile Leu Glu Gly Val Pro Ala Pro Glu Pro Ala Gly Thr Gly
420 425 430
Gln Ala Pro Leu Leu Leu Ser Ala Arg Ser Val Ser Ala Leu Ala Glu
435 440 445
Phe Glu Ser Arg Ile Ala Gly Leu Val Pro Ser Arg Asp Leu Ala Ala
450 455 460
Thr Leu Ala Gly Arg Ala Phe Phe Asp His Arg Ala Val Ile Leu Pro
465 470 475 480
Asp Gly Asp Val Val Arg Gly Arg Ala Gly Gly Ala Pro Leu Val Phe
485 490 495
Val Phe Ala Gly Gln Gly Ser Gln Arg Ala Asp Met Ala Ser Arg Leu
500 505 510
Ala Glu Glu Phe Pro Ala Phe Ala Ala Ala His Glu Arg Val Trp Ser
515 520 525
Leu Leu Asp Val Asp Glu Gly Leu Asp Val Asp Gln Thr Gly Leu Ala
530 535 540
Gln Pro Ala Leu Phe Ala Tyr Glu Val Ala Leu Ala Glu Leu Leu Gly
545 550 555 560
Val Arg Pro Asp Ala Val Ile Gly His Ser Ile Gly Glu Leu Ala Ala
565 570 575
Ala Tyr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Cys Arg Leu Val
580 585 590
Ser Ala Arg Ala Arg Leu Met Gln Asp Leu Pro Ser Gly Gly Ala Met
595 600 605
Val Ser Val Arg Val Ser Glu Glu Ala Ala Arg Ala Val Leu Arg Asp
610 615 620
Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gln Ala Ile Val Leu Ser
625 630 635 640
Gly Asp Glu Asp Ala Val Leu Ala Ala Ala Ala Glu Leu Gly Glu Phe
645 650 655
Arg Arg Leu Arg Thr Ser His Ala Phe His Ser Gly Arg Met Glu Pro
660 665 670
Met Leu Glu Glu Phe Arg Leu Val Ala Ser Ser Val Val Phe Arg Glu
675 680 685
Pro Glu Ile Ala Met Ser Phe Val Pro Ser Ala Asp Tyr Phe Val Arg
690 695 700
Gln Val Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ser Phe Asp
705 710 715 720
Ala Gly Ala Val Phe Val Glu Val Gly Pro Asp Gly Ser Leu Ser Arg
725 730 735
Leu Thr Gly Gly Val Ser Ala Ala Glu Pro Leu Thr Ala Leu Ala Tyr
740 745 750
Leu Trp Val Arg Gly Val Gly Val Asp Trp Ala Pro Tyr Val Gly Gly
755 760 765
Gly Arg Leu Asp Leu Gly Ala Pro Thr Tyr Pro Phe Gln Arg Glu Arg
770 775 780
Tyr Trp Val Arg Pro Arg Leu Ala Gly Arg Thr Thr Asp Glu Arg Asp
785 790 795 800
Ala Leu Leu Ile Ser Leu Val Arg Asp Asp Val Ala Ser Val Leu Gly
805 810 815
His Pro Asp Arg Arg Arg Leu Ala Thr Asp Arg Pro Leu Leu Glu Leu
820 825 830
Gly Phe Asp Ser Leu Thr Ala Leu Arg Leu Arg Asn Arg Leu Ala Ala
835 840 845
Ala Thr Asp Ile Ala Leu Pro Ala Thr Leu Ile Phe Asp Tyr Pro Asn
850 855 860
Ile Gln Ala Ile Ala Val His Leu
865 870
<210> 137
<211> 898
<212> PRT
<213> Actinoplanes sp.
<400> 137
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val
1 5 10 15
Ala Ser Ala Asp Asp Leu Trp Arg Leu Val Thr Ala Gly Gly Asp Ala
20 25 30
Ile Gly Pro Phe Pro Asp Asp Arg Gly Trp Glu Leu Glu Ser Leu Val
35 40 45
Asp Pro Asp Pro Glu Ala Val Gly Arg Ser Thr Thr Gly Gln Gly Gly
50 55 60
Phe Leu Ala Asp Ala Ala Gly Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Ala Ala Leu Glu His Ala Gly Leu Arg Ala Asp Ala Leu
100 105 110
Arg Gly Ser Ala Thr Gly Val Phe Met Gly Ser Asn Gly Gln Asp Tyr
115 120 125
Ala Gly Leu Leu Ala Gly Ala Pro Glu Leu Glu Gly Trp Ile Gly Thr
130 135 140
Gly Val Ser Ala Ser Val Val Ser Gly Arg Leu Ser Tyr Phe Tyr Gly
145 150 155 160
Phe Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
165 170 175
Val Ala Leu His Leu Ala Ala Gln Ser Leu Arg Thr Gly Glu Ser Ser
180 185 190
Leu Ala Leu Val Gly Gly Val Thr Val Met Thr Ser Pro Thr Val Phe
195 200 205
Arg Ser Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys
210 215 220
Ala Phe Ser Ala Gly Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly
225 230 235 240
Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Asn His Gln
245 250 255
Ile Leu Ala Leu Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser
260 265 270
Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Thr
275 280 285
Ala Ala Leu Thr Asp Ala Arg Leu Thr Thr Thr Asp Ile Asp Leu Val
290 295 300
Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln
305 310 315 320
Ala Ile Leu Ala Thr Tyr Gly Asn Arg Thr Thr Gly Asn Pro Val His
325 330 335
Leu Gly Ser Val Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly
340 345 350
Ile Ala Gly Val Ile Lys Ala Ile Gln Ala Ile Arg His Thr Thr Met
355 360 365
Pro Lys Ser Leu His Ile Asp Gln Pro Ser Pro His Val Asp Trp Thr
370 375 380
Ser Gly Arg Val Glu Leu Leu Thr Ser Asn Gln Pro Trp Pro Ala Thr
385 390 395 400
Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr
405 410 415
Asn Ala His Val Ile Leu Glu Glu Ala Pro Ala Pro Ala Glu Ala Val
420 425 430
Pro Pro Ile Arg Pro Val Val Ser Gly Pro Ala Leu Pro Leu Val Phe
435 440 445
Ser Ala Arg Asp Ser Gly Ala Leu Ala Thr Arg Thr His Leu Ser Asp
450 455 460
Gly Pro Gly Val Ala Tyr Ala Leu Ala Thr Ser Arg Ser Met Phe Asp
465 470 475 480
His Arg Ser Val Arg Ile Gly Asp Met Thr Val Thr Gly Val Ala Thr
485 490 495
Thr Asp Pro Glu Val Val Phe Val Phe Pro Gly Gln Gly Thr Gln Trp
500 505 510
Ala Gly Met Gly Arg Ala Leu Met Asp Ala Ser Pro Val Phe Ala Glu
515 520 525
Arg Met Asn Glu Cys Ala Ala Ala Leu Glu Pro Tyr Leu Asp Leu Trp
530 535 540
Ala Ala Ile Asp Ala Pro Asp Gln Val Glu Thr Leu Gln Pro Ala Ser
545 550 555 560
Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val
565 570 575
Arg Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala
580 585 590
Cys Val Ala Gly Ser Ile Thr Leu Gln Asp Ala Ala Ala Val Val Ala
595 600 605
Leu Arg Ser Lys Ala Ile Ala Ala Ser Leu Gly Lys Gly Ala Met Ala
610 615 620
Ser Ile Pro Leu Pro Val Glu Glu Ile Glu Leu Ile Asp Glu Val Trp
625 630 635 640
Val Ala Ala Leu Asn Gly Pro Ser Ser Thr Val Val Ala Gly Ala Pro
645 650 655
Asp Ala Val Glu Gln Val Arg Ala Arg Tyr Asp Gly Arg Arg Ile Ala
660 665 670
Val Asp Tyr Ala Ser His Thr Pro His Val Glu Ala Leu Arg Gly Gln
675 680 685
Val Val Ser Val Pro Ser Gln Thr Pro Ala Val Pro Trp Phe Ser Thr
690 695 700
Val Asp Ser Glu Trp Val Glu Gly Gln Leu Asp Asp Asp Tyr Trp Phe
705 710 715 720
Arg Asn Leu Arg Gln Pro Val Gln Phe Gly Pro Ala Ala Ala Arg Phe
725 730 735
Asp Asp Ala Val Phe Ile Glu Val Ser Ala Arg Pro Val Leu Ile Pro
740 745 750
Ala Leu Asp Ala Ser Val Thr Val Pro Ser Leu Arg Arg Asp Asp Gly
755 760 765
Gly Pro Glu Arg Met Leu Ala Ser Leu Ala Gln Ala Phe Val Ala Gly
770 775 780
Val Ala Val Asp Trp Thr Thr Ile Val Pro Pro Ala Pro Phe Val Asp
785 790 795 800
Leu Pro Thr Tyr Pro Phe Gln His Glu Arg Phe Trp Ile Glu Gly Arg
805 810 815
Val Ala Ala Ala Thr Gly Ala Glu Arg Pro Arg Ile Leu Leu Glu Val
820 825 830
Val Leu Ala Glu Thr Ala Thr Val Leu Gly His Gly Gly Ala Ala Ala
835 840 845
Ile Gly Pro Asp Arg Ala Phe Gln Asp Leu Gly Phe Asp Ser Leu Thr
850 855 860
Ala Val Glu Leu Arg Asn Arg Leu Ala Ala Ala Thr Ala Leu Thr Leu
865 870 875 880
Pro Thr Thr Leu Val Phe Asn His Pro Thr Pro Glu Ala Leu Ala Ala
885 890 895
His Leu
<210> 138
<211> 944
<212> PRT
<213> Actinoplanes sp.
<400> 138
Glu Leu Val Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Asp Val
1 5 10 15
Ala Ser Pro Glu Asp Leu Trp Arg Leu Val Ala Glu Gly Arg Asp Ala
20 25 30
Val Gly Pro Phe Pro Ala Asp Arg Gly Trp Asn Leu Gly Thr Leu Asp
35 40 45
Asp Pro Asp Ala Ala Gly Arg Ser Tyr Val Lys Glu Gly Gly Phe Leu
50 55 60
Ala Gly Ala Ala His Phe Asp Pro Gly Phe Phe Gly Ile Gly Pro Arg
65 70 75 80
Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Ile Ala
85 90 95
Trp Glu Ser Leu Glu Arg Ala Arg Ile Ala Pro Gly Ser Leu Arg Gly
100 105 110
Ser Glu Thr Gly Val Tyr Val Gly Ala Ala Ala Gln Gly Tyr Gly Val
115 120 125
Asp Ala Pro Leu Glu Gly Asn Leu Leu Thr Gly Gly Ser Thr Ser Ala
130 135 140
Met Ser Gly Arg Val Ala Tyr Ser Leu Gly Leu His Gly Pro Ala Val
145 150 155 160
Thr Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala
165 170 175
Ala Gln Ala Leu Arg Asn Gly Glu Cys Thr Leu Ala Leu Ala Gly Gly
180 185 190
Val Ala Val Met Ala Ser Pro Val Leu Phe Thr Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Ala Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ser Glu Gly Ala Gly Leu Val Val Leu Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Arg His Gly His Pro Val Leu Ala Val Ile Arg
245 250 255
Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Thr Ala Gln Arg Arg Val Ile Arg Ser Ala Leu Arg Ala Ala
275 280 285
Gly Leu Gly Ala Gly Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Val Glu Ala Asp Ala Leu Ile Ala Thr Tyr
305 310 315 320
Gly Gln Arg Pro Gly Met Pro Pro Val Arg Ile Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Val Ala Ala Ala Gly Val Ala Gly Val Ile Lys
340 345 350
Met Val Glu Ala Met Arg His Asp Thr Met Pro Arg Thr Leu His Val
355 360 365
Asp Arg Pro Thr Pro His Val Asp Trp Ser Ala Gly Ala Ala Glu Leu
370 375 380
Leu Thr Gly Glu Gln Pro Trp Pro Arg Gly Asp Arg Pro Arg Arg Ala
385 390 395 400
Ala Val Ser Ala Phe Gly Leu Ser Gly Thr Asn Ala His Leu Ile Leu
405 410 415
Glu Asp Val Ala Pro Gly Ala Ala Ser Gly Ala Glu Pro Pro Gly Ala
420 425 430
Ala Asp Glu Thr Val Pro Leu Leu Leu Ser Ala Asp Asp Leu Pro Ala
435 440 445
Val Arg Asp Gln Ala Ala Arg Leu Arg Ala Tyr Leu Leu Ala Arg Pro
450 455 460
Glu Leu Arg Met Arg Asp Val Ala Tyr Ala Leu Ala Thr Thr Arg Thr
465 470 475 480
Ala Arg Pro His Arg Ala Ala Val Ala Ala Thr Glu Arg Glu Phe Leu
485 490 495
Arg Glu Leu Ala Leu Leu Ala Ala Gly Asp Gln Gly Pro Gly Thr Gln
500 505 510
Leu Gly Glu Ala Val Pro His Arg Arg Val Ala Phe Leu Phe Asp Gly
515 520 525
Gln Gly Thr Gln Arg His Gly Met Gly Arg Ala Leu His Gln Arg His
530 535 540
Pro Val Phe Ala Ala Ala Trp Asp Glu Val Cys Ala Ala Leu Asp Pro
545 550 555 560
Leu Leu Gly Arg Gly Val Ala Asp Val Tyr Phe Ala Glu Ala Gly Arg
565 570 575
Asp Leu Ala Asp Asp Pro Leu Tyr Thr Gln Ala Gly Leu Phe Ala Leu
580 585 590
Glu Val Ala Leu Tyr Arg Leu Leu Thr Ser Trp Gly Val Thr Pro Asp
595 600 605
Ala Val Ala Gly His Ser Val Gly Glu Val Ala Ala Ala His Val Ala
610 615 620
Gly Val Leu Ser Leu Pro Asp Ala Ala Ala Leu Leu Ala Ala Arg Gly
625 630 635 640
Ala Ala Leu Arg Arg Leu Pro Ala Gly Ala Met Ala Ala Ile Arg Ala
645 650 655
Ser Glu Ala Asp Thr Arg Ala Val Leu Pro Pro Asp Leu Asp Val Ala
660 665 670
Ala Val Asn Gly Pro Glu Met Thr Val Val Ser Gly Ala Pro Asp Ala
675 680 685
Val Asp Arg Phe Ile Ala Glu Gln Ala Gly Ala Gly Arg Gln Val Arg
690 695 700
Arg Leu Arg Val Gly Arg Ala Tyr His Ser Arg His Val Asp Ala Val
705 710 715 720
Leu Ala Glu Phe Gly Ala Thr Leu Ser Ala Leu Thr Phe His Glu Pro
725 730 735
Val Leu Pro Val Val Ser Thr Val Thr Gly Arg Pro Ala Gly Ala Gly
740 745 750
Asp Leu Thr Thr Pro Glu Tyr Trp Leu Arg His Ala Arg Arg Pro Val
755 760 765
Arg Phe Gly Ala Ala Leu Ala Ala Leu Ser Glu Leu Gly Met Asp Ser
770 775 780
Phe Val Glu Val Gly Pro Ser Gly Ser Leu Ser Ser Met Ala Gly Glu
785 790 795 800
Thr Val Ala Gly Thr Phe His Pro Met Leu Asp Arg Arg Val Pro Asp
805 810 815
Glu Ile Ala Val Ala Ala Gly Glu Leu Phe Thr Ala Gly Met Val Leu
820 825 830
Asp Trp Ala Ala Val Leu Ala Gly Gly Arg Thr Ile Asp Leu Pro Val
835 840 845
Tyr Pro Phe Arg Arg Glu Phe Tyr Trp Leu Gly Ala Arg Arg Tyr Asp
850 855 860
Leu Met Ala Ala Ala Glu Arg Arg Asp Ala Leu Leu Asp Leu Val Arg
865 870 875 880
Val Gln Val Ala Leu Leu Leu Gly Arg Ala Asp Ala Ile Gly Val Arg
885 890 895
Asp Asn Thr Ser Phe Leu Asp Val Gly Leu Asp Ser Leu Gly Ala Ser
900 905 910
Arg Leu Arg Asn Arg Leu Ala Ala Ala Thr Gly Leu Thr Leu Pro Gly
915 920 925
Gly Val Ala Phe Asp His Pro Thr Pro Ala Arg Leu Ala Asp His Leu
930 935 940
<210> 139
<211> 863
<212> PRT
<213> Actinoplanes sp.
<400> 139
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Thr Ser Gly Phe Pro Val Asp Arg Gly Trp Ala Asp Ser Ser Met Arg
35 40 45
Gly Gly Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly
100 105 110
Gly Tyr Gly Ala Gly Ala Asp Leu Gly Gly Phe Gly Val Thr Ala Gly
115 120 125
Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ser Thr Pro Asp Ile Phe Ala Glu
180 185 190
Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe
195 200 205
Ala Asp Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu
210 215 220
Val Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His Gln Val Leu
225 230 235 240
Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Thr His Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Thr Tyr Gly Arg Asp Arg Glu Arg Pro Val Leu Leu Gly Ser
305 310 315 320
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Arg Leu Ala Thr Glu Ser Gln Pro Trp Pro Asp Thr Gly Arg Pro
370 375 380
Arg Arg Ala Ala Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Glu Ser
405 410 415
Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Thr Arg Leu Glu Glu Arg Leu Arg Ala Tyr Leu Thr Ala Glu Ser Asn
435 440 445
Leu Ser Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu
450 455 460
His Arg Ala Val Leu Leu Gly Asp Asp Thr Ile Lys Gly Thr Ala Gln
465 470 475 480
Pro Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg
485 490 495
Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys
500 505 510
Ile Arg Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val
515 520 525
Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Gln Ala Leu Ile
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp
565 570 575
Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ser Leu Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu
595 600 605
Gln Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Ile Ala Ala Val
610 615 620
Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Glu Ala Val Leu
625 630 635 640
Arg Ala Ala Ala Ala Leu Asp Gly Arg Ser Lys Arg Leu Val Thr Ser
645 650 655
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
660 665 670
Ala Val Ala Glu Gln Leu Thr Tyr Arg Ala Pro Arg Ile Pro Met Ala
675 680 685
Val Gly Glu Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Glu Thr Val
690 695 700
Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu
705 710 715 720
Leu Gly Pro Glu Gly Thr Leu Ala Arg Leu Ile Asp Gly Val Ala Val
725 730 735
Leu Asp Arg Glu Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Gly Lys
740 745 750
Leu His Val Arg Gly Val Arg Val Asp Trp Pro Leu Thr Ser Gly Arg
755 760 765
Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg Tyr Trp Ala
770 775 780
Thr Ala Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val
785 790 795 800
Arg Asp Ser Ala Ala Val Val Leu Gly Tyr Thr Asp Ala Val Pro Val
805 810 815
Ser Gly Ser Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu
820 825 830
Leu Arg Asn Ser Leu Ala Thr Thr Thr Gly Leu Arg Leu Pro Ala Thr
835 840 845
Leu Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg Leu
850 855 860
<210> 140
<211> 904
<212> PRT
<213> Actinoplanes sp.
<400> 140
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ala Pro Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Ala Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly
50 55 60
Phe Leu Asp Gly Val Ala Asp Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Asp Pro Ala Asp Ala
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Thr Ser Gly Tyr
115 120 125
Gly Ala Asp Leu Glu Gly Phe Gly Gly Thr Ala Gly Ala Leu Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Phe Ala Leu His Gln Ala
165 170 175
Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Met Ala Leu Val Gly Gly
180 185 190
Val Thr Val Met Ala Thr Pro Arg Thr Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Gly Asp Thr Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu Ala Val Val Arg
245 250 255
Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu His Asn Ala
275 280 285
Arg Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Ala Tyr
305 310 315 320
Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Glu Val Arg Leu Val
370 375 380
Thr Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Gly Pro Pro Thr Gln Pro Pro Ala Thr Ala Pro Gln Glu Pro Ala Pro
420 425 430
Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala Asp Tyr Glu Gly
435 440 445
Arg Leu Arg Ala Tyr Leu Ala Ala Thr Pro Gly Thr Asp Ala Arg Ala
450 455 460
Leu Ala Val Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly
465 470 475 480
Asp Asp Thr Ile Ser Gly Ala Ala Val Thr Asp Pro Arg Val Val Phe
485 490 495
Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Val Ala Leu
500 505 510
Arg Asp Ser Ser Val Val Phe Ala Glu Arg Met Thr Glu Cys Ala Ala
515 520 525
Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp
530 535 540
Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala
545 550 555 560
Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val His Pro
565 570 575
Asp Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val
580 585 590
Ala Gly Ala Ile Ser Leu Arg Asp Ala Ala Arg Val Val Ala Leu Arg
595 600 605
Ser Arg Leu Ile Gly Glu Arg Leu Gly Gln Gly Ala Met Ala Ser Val
610 615 620
Thr Leu Pro Ala Asp Glu Ile Ser Leu Val Asp Gly Val Trp Ile Ala
625 630 635 640
Ala Tyr Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Ser Pro Asp Ala
645 650 655
Val Asp Gln Met Val Gly Asp Arg Val Arg Arg Ile Ala Val Asp Tyr
660 665 670
Ala Ser His Ser Pro Gln Val Glu Gln Ile Lys Asp Glu Leu Leu Asp
675 680 685
Ile Thr Ala Asp Val Gly Ser Arg Thr Pro Thr Val Pro Trp Phe Ser
690 695 700
Thr Val Asp Gly Ser Trp Ile Glu Gly Pro Leu Asp Ala Asp Tyr Trp
705 710 715 720
Tyr Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Glu Ala
725 730 735
Leu Arg Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro
740 745 750
Val Leu Leu Pro Ala Met Asp Asp Ala Leu Thr Val Ala Thr Leu Arg
755 760 765
Arg Asp Asp Gly Thr Ile Ala Arg Met His Thr Ala Leu Ala Glu Ala
770 775 780
His Val His Gly Val Asn Val Asp Trp Ala Ala Val Leu Gly Val Ala
785 790 795 800
Ala Arg His Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Phe
805 810 815
Trp Ala Asp Glu Arg Glu Leu Ala Ser Leu Gly Pro Ala Glu Arg Glu
820 825 830
Gln Ala Leu Arg Lys Leu Val Ser Asp Thr Ala Ala Gly Val Leu Gly
835 840 845
Tyr Ala Asp Pro Gly Ala Val Pro Ile Lys Ala Ala Phe Arg Glu Leu
850 855 860
Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys
865 870 875 880
Ala Thr Gly Met Arg Leu Pro Ala Thr Met Val Phe Asp Tyr Pro Thr
885 890 895
Pro His Ala Leu Ala Ala Arg Leu
900
<210> 141
<211> 909
<212> PRT
<213> Actinoplanes sp.
<400> 141
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Arg Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Glu Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Ser Gly Gly Tyr
115 120 125
Gly Ala Asp Val Glu Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser Val
130 135 140
Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile
145 150 155 160
Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala
165 170 175
Gly Tyr Ser Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly
180 185 190
Ala Thr Val Met Ala Lys Pro Gln Ser Phe Val Glu Phe Ser Arg Gln
195 200 205
Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala
210 215 220
Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg
225 230 235 240
Leu Ser Asp Ala Glu Arg Asn Gly His Gln Val Leu Ala Val Val Arg
245 250 255
Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
260 265 270
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala
275 280 285
Arg Leu Thr Ala Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly
290 295 300
Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Ala Tyr
305 310 315 320
Gly Gln Asp Arg Glu Trp Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn
325 330 335
Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
340 345 350
Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr Leu His Val Asp
355 360 365
Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg Leu Val
370 375 380
Thr Asp Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg Ala Gly
385 390 395 400
Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu
405 410 415
Ser Pro Pro Thr Gln Pro Ser Gly Thr Phe Lys Lys Pro Ala His Glu
420 425 430
Pro Gln Pro Leu Ile Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala Asp
435 440 445
Tyr Glu Asp Arg Leu Gly Ala Tyr Leu Thr Ala Ala Pro Gly Val Asp
450 455 460
Val Pro Ala Val Ala Ala Thr Leu Ala Val Thr Arg Ser Leu Phe Glu
465 470 475 480
His Arg Ala Val Leu Leu Gly Asp Asn Thr Val Thr Gly Thr Ala Ile
485 490 495
Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp
500 505 510
Leu Gly Met Gly Ala Ala Leu Arg Gly Ser Ser Val Val Phe Ala Glu
515 520 525
Arg Met Thr Glu Cys Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp
530 535 540
Leu Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg Val Asp Val
545 550 555 560
Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala Ala Val Trp
565 570 575
Gln Ala Ala Gly Val His Pro Asp Ala Val Val Gly His Ser Gln Gly
580 585 590
Glu Ile Ala Ala Ala Cys Val Ala Ser Ala Val Ser Leu Arg Asp Ala
595 600 605
Ala Arg Val Val Ala Leu Arg Ser Arg Leu Ile Ser Glu Arg Leu Gly
610 615 620
Gln Gly Ala Met Ala Ser Val Ala Leu Pro Ala Asp Gln Ile Val Leu
625 630 635 640
Ala Asp Gly Val Trp Ile Ala Ala His Asn Gly Pro Thr Ser Thr Val
645 650 655
Val Ala Gly Ser Pro Asp Ala Val Glu Gln Met Leu Gly Asp Arg Val
660 665 670
Arg Lys Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln
675 680 685
Ile Lys Thr Glu Leu Leu Gly Ile Thr Ala Gly Ile Gly Ser Arg Thr
690 695 700
Pro Thr Val Pro Trp Phe Ser Thr Val Asp Gly Ser Trp Ile Glu Gly
705 710 715 720
Pro Leu Asp Ala Asp Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Gly
725 730 735
Phe Asp Ala Ala Val Gly Arg Leu Arg Ala Leu Gly Ala Thr Val Phe
740 745 750
Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asp Asp Ala
755 760 765
Val Thr Ile Ala Thr Leu Arg Arg Asp Glu Gly Ser Ile Thr Arg Met
770 775 780
His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Asn Val Asp Trp
785 790 795 800
Pro Thr Leu Leu Gly Asp Thr Asp Arg Arg Ala Leu Asp Leu Pro Thr
805 810 815
Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Gly Asp Ala Ala Gly Leu Ala
820 825 830
Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Leu Val Arg Asp Ser Ala
835 840 845
Ala Leu Val Leu Gly Tyr Ala Gly Gly Asp Ala Val Pro Ala Thr Asp
850 855 860
Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg
865 870 875 880
Asn Gly Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
885 890 895
Phe Asp Tyr Pro Thr Pro Gln Val Leu Ala Ala Arg Leu
900 905
<210> 142
<211> 867
<212> PRT
<213> Actinoplanes sp.
<400> 142
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Thr Ser Gly Phe Pro Val Asp Arg Gly Trp Ala Asp Ser Ser Met Arg
35 40 45
Gly Gly Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Ser Val Arg Gly Ser Asp Ile Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Leu Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Thr Phe Val Glu
180 185 190
Phe Ala Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Ser Lys Ala Phe
195 200 205
Ala Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His Gly His Arg Val Leu
225 230 235 240
Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu Ala His Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Thr Tyr Gly Gln Asp Arg Asp Glu Pro Leu Leu Leu Gly Ser
305 310 315 320
Val Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr
340 345 350
Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Arg Leu Leu Thr Glu Lys Gln Pro Trp Pro Ser Thr Asp Arg Pro
370 375 380
Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Asp Ser
405 410 415
Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu
420 425 430
Thr Gln Val Glu Glu Arg Leu Arg Ala Tyr Leu Thr Ala Glu Ser Asn
435 440 445
Leu Ser Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu
450 455 460
His Arg Ala Val Leu Leu Asp Gly His Ala Val Arg Gly Val Ala Glu
465 470 475 480
Ser Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg
485 490 495
Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Lys
500 505 510
Ile Arg Gly Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val
515 520 525
Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala
530 535 540
Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro His Ala Leu Ile
545 550 555 560
Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp
565 570 575
Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg Ala Arg Leu Met
580 585 590
Gln Ala Leu Pro Pro Gly Gly Ala Met Val Ala Val Pro Val Ser Glu
595 600 605
Gln Gln Ala Arg Ala Val Leu Thr Asp Gly Val Glu Val Ala Ala Val
610 615 620
Asn Gly Pro Ser Ser Ala Val Leu Ser Gly Asp Glu Glu Ala Val Leu
625 630 635 640
Arg Ala Ala Ala Ala Leu Gly Gly Arg Trp Lys Arg Leu Ala Thr Ser
645 650 655
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Arg
660 665 670
Ala Val Ala Glu Gln Leu Thr Tyr Arg Ala Pro Arg Ile Pro Met Ala
675 680 685
Val Gly Glu Gly Pro Glu Tyr Trp Val Arg Gln Val Arg Glu Thr Val
690 695 700
Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala Val Phe Val Glu
705 710 715 720
Leu Gly Pro Asp Gly Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr
725 730 735
Leu Asp Arg Asp Asp Glu Pro Arg Val Ala Leu Thr Ala Leu Ala Glu
740 745 750
Leu His Val Arg Gly Val Asp Val Asp Trp Pro Leu Thr Ser Gly Arg
755 760 765
Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ile
770 775 780
Asp Arg Ala Gly Arg Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys
785 790 795 800
Val Val Arg Asp Ser Ala Ala Thr Val Leu Gly His Ala Asp Gly Gly
805 810 815
Ser Val Gly Ala Ala Ala Ala Phe Lys Asp Leu Gly Val Asp Ser Leu
820 825 830
Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg
835 840 845
Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala Val Ala
850 855 860
Val Arg Leu
865
<210> 143
<211> 900
<212> PRT
<213> Actinoplanes sp.
<400> 143
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Thr Ser Gly Phe Pro Thr Asp Arg Gly Trp Ala Asp Ser Ser Met Arg
35 40 45
Gly Gly Phe Leu Val Ala Ala Ala Asp Phe Asp Ala Ala Phe Phe Gly
50 55 60
Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val
65 70 75 80
Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly
85 90 95
Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly
100 105 110
Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe Gly Ala Thr Ala Gly
115 120 125
Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu
130 135 140
Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
145 150 155 160
Leu His Gln Ala Gly His Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
165 170 175
Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Leu Phe Val Glu
180 185 190
Phe Ala Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe
195 200 205
Gly Asp Thr Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu
210 215 220
Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Arg Val Leu
225 230 235 240
Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
245 250 255
Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala
260 265 270
Leu His Asn Ala Arg Leu Thr Pro Ala Asp Val Asp Val Val Glu Ala
275 280 285
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val
290 295 300
Ile Ala Ala Tyr Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser
305 310 315 320
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly
325 330 335
Val Ile Lys Met Val Met Ala Leu Gln His Gly Val Val Pro Arg Thr
340 345 350
Leu His Val Asp Glu Pro Ser Ser His Val Asp Trp Thr Ala Gly Ala
355 360 365
Val Arg Leu Val Thr Glu Asn Gln Ser Trp Pro Asp Thr Gly Arg Pro
370 375 380
Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His
385 390 395 400
Val Ile Leu Glu Ser Ser Ala Ala Pro Ser Pro Thr Ile Pro Gln Pro
405 410 415
Pro Ser Ala Glu Pro Met Pro Leu Val Ile Ser Ala Lys Thr Pro Ala
420 425 430
Ala Leu Ala Asp Tyr Glu Gly Arg Leu Arg Ala Tyr Leu Thr Ala Pro
435 440 445
Gly Val Asp Val Pro Ala Val Ala Ala Thr Leu Ala Val Thr Arg Ser
450 455 460
Leu Phe Glu His Arg Ala Val Leu Leu Gly Gly Asn Thr Val Thr Gly
465 470 475 480
Thr Ala Val Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly
485 490 495
Trp Gln Trp Leu Gly Met Gly Ala Ala Leu Arg Gly Ser Ser Val Val
500 505 510
Phe Ala Glu Arg Met Thr Glu Cys Ala Ala Ala Leu Ser Glu Phe Val
515 520 525
Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala Val Val Asp Arg
530 535 540
Val Asp Val Val Gln Pro Ala Cys Trp Ala Val Met Val Ser Leu Ala
545 550 555 560
Ala Val Trp Gln Ala Ala Gly Val His Pro Asp Ala Val Val Gly His
565 570 575
Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu
580 585 590
Arg Asp Ala Ala Arg Val Val Ala Leu Arg Ser Arg Leu Ile Gly Glu
595 600 605
Arg Leu Gly Arg Gly Ala Met Ala Ser Val Ser Leu Pro Ala Asp Gln
610 615 620
Ile Val Leu Ala Asp Gly Val Trp Ile Ala Ala His Asn Gly Pro Ala
625 630 635 640
Ser Thr Val Ile Ala Gly Gly Ala Gly Ala Val Asp Gln Met Val Gly
645 650 655
Glu Arg Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro Asp
660 665 670
Val Glu Gln Ile Gln Thr Glu Leu Leu Asp Ile Thr Ala Asp Val Gly
675 680 685
Ser Gln Ala Pro Val Val Pro Trp Phe Ser Thr Val Asp Gly Val Trp
690 695 700
Val Asp Gly Pro Leu Asp Arg Asp Tyr Trp Tyr Arg Asn Leu Arg Gln
705 710 715 720
Pro Val Gly Phe His Pro Ala Val Glu Ala Leu Gln Ala Leu Gly Glu
725 730 735
Thr Val Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Pro Ala Met
740 745 750
Asp Asp Ala Val Thr Val Ala Thr Leu Arg Arg Asp Glu Gly Ser Ile
755 760 765
Thr Arg Met His Thr Ala Leu Ala Glu Ala His Val Leu Gly Val Asn
770 775 780
Val Asp Trp Pro Thr Val Val Gly Asp Thr Asp Arg Arg Thr Leu Asp
785 790 795 800
Leu Pro Thr Tyr Ala Phe Gln His His Arg Tyr Trp Ile Ser Ala Ala
805 810 815
Ala Arg Leu Asp Gly Leu Thr Ala Ala Glu Lys His Ser Leu Leu Leu
820 825 830
Asp Ile Val Leu Ala Asn Ala Ala Thr Val Leu Gly His His Thr Val
835 840 845
Asp Thr Ile Ala Pro Asp Lys Pro Phe Lys Asp Leu Gly Ile Asp Ser
850 855 860
Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Ala Thr Gly Leu
865 870 875 880
Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Asp Met Ala
885 890 895
Ala Ala Arg Leu
900
<210> 144
<211> 873
<212> PRT
<213> Actinoplanes sp.
<400> 144
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Thr Asp Arg Gly Trp Ala Asp Ala Ala Gly Ala
35 40 45
Pro Tyr Ser Pro Gln Gly Gly Phe Val Asp Ala Ala Ala Asp Phe Asp
50 55 60
Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro
65 70 75 80
Gln Gln Arg Leu Val Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala
85 90 95
Gly Ile Glu Pro Gly Thr Val Arg Gly Ser Asp Thr Gly Val Phe Met
100 105 110
Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala Asp Gln Ala Gly Phe
115 120 125
Gly Thr Thr Ala Gly Ala Gly Ser Val Leu Ser Gly Arg Val Ser Tyr
130 135 140
Phe Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser
145 150 155 160
Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly
165 170 175
Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Gly Thr Pro
180 185 190
Asp Ile Phe Ala Glu Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly
195 200 205
Arg Cys Lys Ala Phe Gly Asp Asp Ala Asp Gly Thr Gly Trp Gly Glu
210 215 220
Gly Val Gly Ile Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Arg His
225 230 235 240
Ser His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp
245 250 255
Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg
260 265 270
Val Ile Gln Ala Ala Leu Ala His Ala Gly Leu Ala Pro His Glu Val
275 280 285
Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile
290 295 300
Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly Gln Asp Arg Asp Glu Pro
305 310 315 320
Leu Leu Leu Gly Ser Val Lys Ser Asn Val Gly His Thr Gln Ala Ala
325 330 335
Ala Gly Val Ala Gly Val Ile Lys Met Val Met Ala Leu Arg His Gly
340 345 350
Val Val Pro Arg Thr Leu His Ala Asp Gln Pro Ser Arg His Val Asp
355 360 365
Trp Thr Ala Gly Ala Val Arg Leu Ala Thr Glu Asn Gln Pro Trp Pro
370 375 380
Ala Ile Asp Arg Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser
385 390 395 400
Gly Thr Asn Ala His Val Ile Leu Glu Gly Val Ala Glu Glu Pro Ala
405 410 415
Gln Ser Glu Glu Ser Ser Pro Leu Met Pro Leu Val Ile Ser Ala Lys
420 425 430
Thr Pro Ala Ala Leu Thr Arg Leu Glu Glu Arg Leu Arg Ala Tyr Leu
435 440 445
Ala Ala Lys Pro Glu Thr Ser Leu Gly Ala Val Ala Ser Thr Leu Ala
450 455 460
Glu Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Asn Gly Asp
465 470 475 480
Val Val Arg Gly Val Ala Glu Pro Asn Pro Arg Val Val Phe Val Phe
485 490 495
Ser Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Asp Glu Val Ala Ala
500 505 510
Ala Phe Pro Val Phe Ala Lys Ile Arg Arg Gln Val Trp Asp Leu Leu
515 520 525
Asp Val Pro Asp Leu Asp Val Asn Asp Thr Gly His Ala Gln Pro Ala
530 535 540
Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly
545 550 555 560
Val Arg Pro Asp Ala Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala
565 570 575
Gly Tyr Val Ser Gly Ile Trp Ser Leu Glu Asp Ala Cys Ala Leu Val
580 585 590
Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met
595 600 605
Val Ala Val Pro Val Ser Glu Gln Gln Ala Arg Ala Val Leu Thr Asp
610 615 620
Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser
625 630 635 640
Gly Asp Glu Glu Ala Val Leu Arg Ala Ala Ala Gly Leu Gly Ser Arg
645 650 655
Trp Lys Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu
660 665 670
Pro Met Leu Asp Glu Phe Arg Val Val Ala Glu Gln Leu Ser Tyr Lys
675 680 685
Thr Pro Arg Ile Pro Val Ala Val Gly Glu Gly Pro Glu Tyr Trp Val
690 695 700
Arg Gln Val Arg Glu Thr Val Arg Phe Gly Glu His Val Ala Ala His
705 710 715 720
Asp Gly Ala Val Phe Val Glu Leu Gly Pro Asp Gly Ser Leu Ala Arg
725 730 735
Leu Ile Asp Gly Ile Ala Thr Leu Asp Arg Asp Asp Glu Pro Arg Ala
740 745 750
Ala Leu Thr Ala Leu Ala Glu Leu His Val Arg Gly Val Asp Val Asp
755 760 765
Trp Pro Leu Thr Ser Gly Arg Arg Val Asp Leu Pro Thr Tyr Ala Phe
770 775 780
Gln Arg Gln Arg Tyr Trp Thr Thr Ala Gly Leu Thr Arg Ala Glu Arg
785 790 795 800
Glu Gln Ala Leu Leu Lys Leu Val Arg Asp Thr Ala Ala Val Val Leu
805 810 815
Gly Tyr Gly Asp Gly Asn Ala Val Pro Val Thr Ala Ala Phe Lys Asp
820 825 830
Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Gly Leu Ala
835 840 845
Glu Ala Ile Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro
850 855 860
Thr Pro Ala Thr Leu Ala Val Arg Leu
865 870
<210> 145
<211> 871
<212> PRT
<213> Actinoplanes sp.
<400> 145
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Pro Asp Val Thr Gly Thr
35 40 45
Ser His Ser Gln His Gly Gly Phe Leu His Thr Ala Ala Asp Phe Asp
50 55 60
Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro
65 70 75 80
Gln Gln Arg Leu Ile Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala
85 90 95
Gly Ile Asn Pro Ala Asp Ala His Gly Thr Asp Thr Gly Val Phe Met
100 105 110
Gly Ala Phe Ser Ala Gly Tyr Asp Ala Asp Arg Asp Asp Ser Pro Ala
115 120 125
Thr Ala Gly Ala Val Ser Val Leu Ser Gly Arg Ile Ser Tyr Phe Phe
130 135 140
Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser
145 150 155 160
Leu Val Ala Leu His Gln Ala Gly Tyr Ser Leu Arg Gln Gly Glu Cys
165 170 175
Ser Met Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro Arg Thr
180 185 190
Phe Val Glu Phe Ser Arg Gln Gly Gly Leu Ala Ser Asp Gly Arg Cys
195 200 205
Lys Ala Phe Gly Asp Thr Ala Asp Gly Thr Gly Trp Ser Glu Gly Val
210 215 220
Gly Val Leu Val Val Glu Arg Leu Ser Asp Ala Arg Ala Lys Gly His
225 230 235 240
Arg Val Leu Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala
245 250 255
Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile
260 265 270
Gln Ala Ala Leu His Asn Ala His Leu Thr Pro Ala Asp Val Asp Val
275 280 285
Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala
290 295 300
Gln Ala Val Ile Ala Ala Tyr Gly Gln Asp Arg Asp Glu Pro Leu Leu
305 310 315 320
Leu Gly Ser Ile Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly
325 330 335
Val Ser Gly Val Ile Lys Met Val Met Ala Leu Arg His Gly Val Val
340 345 350
Pro Arg Thr Leu His Ala Asp Gln Pro Ser Arg His Val Asp Trp Asn
355 360 365
Ala Gly Ala Val Gln Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr
370 375 380
Gly Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr
385 390 395 400
Asn Ala His Val Ile Leu Glu Gly Val Pro Glu Gln Pro Ala Gln Pro
405 410 415
Glu Pro Pro Ser Glu Arg Val Pro Leu Met Ile Ser Ala Lys Ser Thr
420 425 430
Ser Ala Leu Ser Gln Leu Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala
435 440 445
Arg Pro Glu Ala Ser Leu Gly Ala Val Ala Ser Thr Leu Ala Thr Arg
450 455 460
Ser Leu Phe Glu His Arg Ala Val Leu Leu Asp Gly Gln Val Val Lys
465 470 475 480
Gly Val Ala Glu Pro Asn Pro Arg Val Val Phe Val Phe Ser Gly Gln
485 490 495
Gly Ser Gln Arg Ala Gly Met Gly Asp Glu Leu Ala Ala Ala Phe Pro
500 505 510
Val Phe Ala Lys Ile Arg Gly Gln Val Trp Asp Leu Leu Asp Val Pro
515 520 525
Asp Leu Asp Val Asn Asp Thr Gly His Ala Gln Pro Ala Leu Phe Ala
530 535 540
Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro
545 550 555 560
Asp Ala Leu Ile Gly His Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val
565 570 575
Ser Gly Ile Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg
580 585 590
Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val Ala Val
595 600 605
Pro Val Ser Glu Gln Gln Ala Arg Ala Val Leu Thr Gly Gly Val Glu
610 615 620
Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu
625 630 635 640
Gly Ala Val Leu Arg Ala Ala Ala Ala Leu Gly Gly Arg Trp Lys Arg
645 650 655
Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu
660 665 670
Asp Glu Phe Arg Ala Ala Ala Glu Gln Leu Thr Tyr Gln Thr Pro Arg
675 680 685
Ile Pro Met Val Val Gly Asp Gly Pro Asp Tyr Trp Val Arg Gln Val
690 695 700
Arg Glu Thr Val Arg Phe Gly Glu Gln Val Ala Ala His Asp Gly Ala
705 710 715 720
Val Phe Val Glu Leu Gly Pro Asp Arg Ser Leu Ala Arg Leu Ile Asp
725 730 735
Gly Ile Ala Thr Leu Asp Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr
740 745 750
Ala Leu Ala Glu Leu His Val Arg Gly Val Asp Val Asp Trp Pro His
755 760 765
Asp Gly Gln Leu Val Asp Leu Pro Thr Tyr Ala Phe Gln Arg Glu Arg
770 775 780
Tyr Trp Ala Thr Ala Leu Ala Ala Leu Pro Leu Ala Glu Arg Glu Gln
785 790 795 800
Ala Leu Leu Ala Val Val Ser Asp Asn Ala Ala Val Val Leu Gly Tyr
805 810 815
Ala Glu Gly Arg Asp Val Thr Gln Thr Ala Ala Phe Lys Asp Leu Gly
820 825 830
Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Thr Leu Ala Lys Ala
835 840 845
Thr Gly Leu Arg Leu Pro Ala Thr Ile Val Phe Asp Tyr Pro Thr Pro
850 855 860
Asp Thr Leu Ala Ala Arg Leu
865 870
<210> 146
<211> 878
<212> PRT
<213> Actinoplanes sp.
<400> 146
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Arg Phe Pro Asp Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Glu Gly Gly
50 55 60
Phe Leu Asp Ala Val Ala Asp Phe Asp Ala Ala Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ser Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Pro Gly Leu Gly Val Thr Ala Gly Ala Val
130 135 140
Ser Val Val Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly His Ala Leu Arg Arg Arg Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Phe Gly Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Thr Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu Val Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Arg Ala Asn Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ala
275 280 285
His Ala Asp Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Gly Arg Asp Glu Pro Leu Leu Leu Gly Ser Ile Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Arg His Gly Val Val Pro Gln Thr Leu His
355 360 365
Val Asp Glu Pro Thr Gln His Val Asp Trp Thr Ala Gly Ala Val Arg
370 375 380
Leu Ala Thr Glu Asn Gln Pro Trp Pro Asp Thr Gly Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Gly Val Ala Glu Glu Pro Ala Gln Ser Glu Glu Ser Ser Glu
420 425 430
Leu Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu Thr Arg
435 440 445
Leu Glu Glu Arg Leu Arg Ala Tyr Leu Ser Ala Glu Ser Asn Leu Ser
450 455 460
Ala Val Ala Ser Thr Leu Ala Glu Thr Arg Ser Leu Phe Glu His Arg
465 470 475 480
Ala Val Leu Leu Gly Asp Asp Thr Ile Lys Gly Thr Ala Gln Pro Asn
485 490 495
Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
500 505 510
Met Gly Asp Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Arg Ile Arg
515 520 525
Arg Gln Val Trp Asp Leu Leu Asp Val Pro Asp Val Ser Val Asp Asp
530 535 540
Thr Gly Phe Ala Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe
545 550 555 560
Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Leu Ile Gly His
565 570 575
Ser Ile Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Ile Trp Ser Leu
580 585 590
Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala
595 600 605
Leu Pro Ala Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Gln Gln
610 615 620
Ala Arg Ala Val Leu Thr Gly Gly Val Glu Ile Ala Ala Val Asn Gly
625 630 635 640
Pro Ser Ser Val Val Leu Ser Gly Asp Glu Glu Ala Val Leu Arg Ala
645 650 655
Ala Ala Ala Leu Gly Gly Arg Ser Lys Arg Leu Val Thr Ser His Ala
660 665 670
Phe His Ser Ala Arg Met Glu Pro Met Leu Asp Glu Phe Gln Ala Val
675 680 685
Ala Glu Gln Leu Thr Tyr Gln Ala Pro Arg Ile Pro Met Ala Val Gly
690 695 700
Asp Gly Pro Asp Tyr Trp Val Arg Gln Val Arg Glu Thr Val Arg Phe
705 710 715 720
Gly Asp Gln Val Ala Ala Gln Asp Gly Ala Val Phe Val Glu Leu Gly
725 730 735
Pro Asp Arg Ser Leu Ala Arg Leu Ile Asp Gly Ile Ala Thr Leu Asp
740 745 750
Arg Asp Asp Glu Pro Arg Ala Ala Leu Thr Ala Leu Ala Glu Leu His
755 760 765
Val Arg Gly Val Asp Val Asp Trp Pro Leu Thr Ser Gly Arg Arg Val
770 775 780
Asp Leu Pro Thr Tyr Ala Phe Gln Arg Gln Arg Tyr Trp Ile Asp Ser
785 790 795 800
Ala Leu Thr Pro Ala Glu Arg Glu Gln Ala Leu Leu Lys Val Val Arg
805 810 815
Asp Ser Ala Ala Val Val Leu Gly Tyr Thr Asp Ala Val Pro Val Ser
820 825 830
Gly Ser Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu
835 840 845
Arg Asn Ser Leu Ala Lys Val Thr Gly Leu Arg Leu Pro Ala Thr Leu
850 855 860
Val Phe Asp Tyr Pro Thr Pro Ala Thr Leu Ala Ala Arg Leu
865 870 875
<210> 147
<211> 904
<212> PRT
<213> Actinoplanes sp.
<400> 147
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Glu Ser Pro Asp Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Thr Gly Phe Pro Thr Asp Arg Gly Trp Pro Asp Val Thr Gly Thr
35 40 45
Ser His Ser Gln His Gly Gly Phe Leu His Thr Ala Ala Asp Phe Asp
50 55 60
Ala Ala Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro
65 70 75 80
Gln Gln Arg Leu Ile Leu Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala
85 90 95
Gly Ile Asn Pro Ala Asp Ala His Gly Thr Asp Thr Gly Val Phe Met
100 105 110
Gly Ala Tyr Ser Gly Gly Tyr Gly Ile Gly Ala Asp Leu Ala Gly Phe
115 120 125
Gly Ala Thr Ser Gly Ala Thr Ser Val Leu Ser Gly Arg Val Ser Tyr
130 135 140
Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser
145 150 155 160
Ser Ser Leu Val Ala Leu His Gln Ala Gly His Ala Leu Arg Gln Gly
165 170 175
Glu Cys Ala Met Ala Leu Val Gly Gly Val Thr Val Met Ala Thr Pro
180 185 190
Asp Ile Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly
195 200 205
Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr Gly Trp Ala Glu
210 215 220
Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Glu Arg Asn
225 230 235 240
Gly His Arg Val Leu Ala Val Val Arg Ser Ser Ala Val Asn Gln Asp
245 250 255
Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg
260 265 270
Val Ile Gln Ala Ala Leu His Asn Ala Arg Leu Thr Pro Ala Asp Val
275 280 285
Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile
290 295 300
Glu Ala Gln Ala Val Ile Ala Ala Tyr Gly Gln Gly Arg Asp Glu Pro
305 310 315 320
Leu Leu Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala
325 330 335
Ala Gly Val Ser Gly Val Ile Lys Met Val Met Ala Leu Gln His Gly
340 345 350
Val Val Pro Arg Thr Leu His Val Asp Glu Pro Ser Ser His Val Asp
355 360 365
Trp Thr Ala Gly Ala Val Arg Leu Ala Thr Glu Asn Gln Ser Trp Pro
370 375 380
Asp Thr Gly Arg Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser
385 390 395 400
Gly Thr Asn Ala His Val Ile Leu Glu Ser Ser Ala Ala Pro Ser Pro
405 410 415
Thr Ile Pro Gln Pro Pro Ser Ala Glu Pro Met Pro Leu Val Ile Ser
420 425 430
Ala Lys Thr Pro Ala Ala Leu Ala Asp Tyr Glu Asp Arg Leu Arg Ala
435 440 445
Tyr Leu Thr Asn Pro Gly Val Asp Val Pro Ala Val Ala Ala Thr Leu
450 455 460
Ala Met Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Gly
465 470 475 480
Asn Thr Val Thr Gly Thr Ala Val Ala Asp Pro Arg Val Val Phe Val
485 490 495
Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ala Ala Leu Arg
500 505 510
Gly Ser Ser Val Val Phe Ala Glu Arg Met Thr Glu Cys Ala Ala Ala
515 520 525
Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro
530 535 540
Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val
545 550 555 560
Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val His Pro Asp
565 570 575
Ala Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala
580 585 590
Gly Ala Ile Ser Leu Gln Asp Ala Ala Arg Val Val Ala Leu Arg Ser
595 600 605
Gln Ala Ile Ser Gly Leu Ser Gly Lys Gly Ala Met Ala Ser Ile Ala
610 615 620
Leu Pro Ala Asp Gln Ile Ala Leu Pro Asp Gly Ala Trp Ile Ala Ala
625 630 635 640
His Asn Gly Pro Ala Ser Thr Val Val Ala Gly Ser Pro Asp Ala Val
645 650 655
Glu Gln Met Leu Gly Asp Arg Val Arg Lys Ile Ala Val Asp Tyr Ala
660 665 670
Ser His Thr Pro His Val Glu Gln Ile Gln Thr Glu Leu Leu Asp Ile
675 680 685
Thr Ala Gly Ile Gly Ser Arg Thr Pro Thr Ile Pro Trp Phe Ser Thr
690 695 700
Val Asp Gly Met Trp Val Asp Gly Pro Leu Asp Arg Asp Tyr Trp Tyr
705 710 715 720
Arg Asn Leu Arg Gln Pro Val Gly Phe His Pro Ala Val Glu Ala Leu
725 730 735
Gln Ala Leu Gly Glu Thr Val Phe Val Glu Val Ser Ala Ser Pro Val
740 745 750
Leu Leu Pro Ala Met Asp Asp Ala Val Thr Val Ala Thr Leu Arg Arg
755 760 765
Asp Glu Gly Ser Ile Thr Arg Met His Thr Ala Leu Ala Glu Ala His
770 775 780
Val Leu Gly Val Asn Val Asp Trp Pro Thr Leu Leu Gly Asp Thr Gly
785 790 795 800
Arg Arg Thr Leu Asp Leu Pro Thr Tyr Ala Phe Gln His His Arg Tyr
805 810 815
Trp Ile Asn Gly Ser Arg Leu Ile Gly Arg Thr Thr Ala Glu Gln His
820 825 830
Arg Leu Met Leu Ala Phe Val Leu Gly Asn Val Ala Ser Val Leu Gly
835 840 845
His Gly Ser Ala Asp Ala Ile Ala Ala Asp Lys Pro Phe Lys Asp Leu
850 855 860
Gly Met Asp Ser Leu Thr Ser Val Glu Leu Arg Asn Ser Leu Ala Lys
865 870 875 880
Ala Thr Glu Leu Arg Leu Pro Ala Thr Ile Val Phe Asp His Pro Thr
885 890 895
Ala Asp Ala Leu Ala Ala His Leu
900
<210> 148
<211> 947
<212> PRT
<213> Actinoplanes sp.
<400> 148
Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Val Pro Gly Gly Val
1 5 10 15
Thr Ser Pro Glu Gly Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Ala Phe Pro Gly Asp Arg Gly Trp Asp Ile Ala Asn Leu Tyr
35 40 45
Ser Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Gly Ala Ala Ala Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Val Leu Leu Glu
85 90 95
Thr Ala Trp Glu Ala Val Glu Arg Ala Arg Ile Asp Pro Arg Ser Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Leu Gly Ala Ala Glu Ala His Arg Asp Asn Leu Ile Thr Gly Gly
130 135 140
Ser Ile Ser Leu Leu Ser Gly Arg Leu Ser Tyr Ala Leu Gly Leu Glu
145 150 155 160
Gly Pro Gly Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
165 170 175
Leu His Leu Ala Ala Gln Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
180 185 190
Leu Val Ser Gly Val Ser Val Met Pro Thr Pro Asp Val Phe Val Glu
195 200 205
Phe Ser Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ser Phe
210 215 220
Ala Ala Ser Ala Asp Gly Thr Ser Trp Ser Glu Gly Val Gly Val Leu
225 230 235 240
Val Leu Glu Arg Leu Ser Glu Ala Arg Arg Leu Gly His Gln Val Leu
245 250 255
Ala Val Val Arg Gly Thr Ala Val Asn Ser Asp Gly Ala Ser Asn Gly
260 265 270
Leu Thr Ala Pro Asn Gly Ala Ala Gln Gln Arg Val Ile Arg Gln Ala
275 280 285
Leu Ala Asn Ala Gly Leu Ser Thr Ala Asp Val Asp Ala Val Glu Ala
290 295 300
His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile
305 310 315 320
Leu Ala Thr Tyr Gly Lys Asp Arg Ser Thr Pro Val Trp Leu Gly Ser
325 330 335
Leu Lys Ser Asn Ile Gly His Thr Met Ala Ala Ser Gly Val Leu Gly
340 345 350
Val Ile Lys Met Val Glu Ala Met Arg His Gly Val Leu Pro Arg Thr
355 360 365
Leu His Val Asp Glu Pro Ser Pro His Val Asp Trp Ala Ala Gly Glu
370 375 380
Val Ala Leu Leu Thr Glu Asn Gln Thr Trp Pro Gly Asp Val Arg Pro
385 390 395 400
Arg Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His
405 410 415
Val Val Leu Glu Gln Asp Glu Ala Pro Ala Ala Pro Val Thr Thr Lys
420 425 430
Glu Ser Gly Pro Leu Pro Trp Val Leu Ser Ala Gln Ser Pro Lys Ala
435 440 445
Leu Arg Gln Arg Ala Gly Gln Leu Ala Thr Ala Leu Ala Glu Asp Ser
450 455 460
Thr Trp His Pro Leu Asp Val Ala Tyr Ser Leu Ala Thr Thr Arg Ser
465 470 475 480
Asp Phe Ala His Arg Ala Val Val Val Gly Ala Asp Arg Glu Leu Leu
485 490 495
Arg Thr Leu Gly Lys Val Ala Asp Gly Ala Gly Trp Pro Gly Leu Thr
500 505 510
Thr Gly Thr Ala Lys Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln
515 520 525
Gly Thr Gln Arg Leu Thr Met Gly Gln Gly Leu Tyr Gly Ser Phe Pro
530 535 540
Ala Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Glu Phe Gly Lys His
545 550 555 560
Leu Asp His Pro Leu Ala Asp Val Tyr Phe Asp Gly Ser Gly Gly Ala
565 570 575
Ala Thr Ala Asp Leu Val Asp Asp Pro Leu Tyr Ala Gln Ala Gly Ile
580 585 590
Phe Ala Val Glu Val Ala Leu Val Glu Leu Leu Ala Glu Trp Gly Val
595 600 605
Arg Pro Asp Val Val Thr Gly His Ser Ile Gly Glu Ala Ala Ala Ala
610 615 620
Tyr Thr Ala Gly Met Leu Ser Leu Ser Asp Val Thr Thr Leu Ile Val
625 630 635 640
Ala Arg Gly Ala Ala Leu Arg Ser Ala Pro Pro Gly Ala Met Leu Ala
645 650 655
Leu Arg Ala Gly Glu Gln Glu Val Arg Asn Phe Leu Asp Gly Thr Gly
660 665 670
Ala Ala Leu Asp Leu Ala Ala Val Asn Gly Pro Ala Ala Val Val Val
675 680 685
Ser Gly Ala Pro Asp Ala Val Thr Asp Phe Ala Ser Ala Trp Thr Ala
690 695 700
Ser Gly Arg Glu Ala Arg Arg Leu Lys Val Arg Arg Ala Phe His Ser
705 710 715 720
Arg His Val Glu Gly Val Leu Asp Asp Phe Arg Thr Ala Leu Glu Ser
725 730 735
Leu Ser Phe Arg Thr Pro Leu Leu Pro Val Val Ser Thr Val Thr Gly
740 745 750
Arg Leu Ile Asp Pro Ala Glu Met Gly Thr Pro Glu Tyr Trp Leu Asp
755 760 765
Gln Val Arg Gln Pro Val Arg Phe Gln Glu Ala Val Gln Glu Leu Ala
770 775 780
Gly Gln Gly Val Gly Thr Phe Val Glu Val Gly Pro Ser Gly Thr Leu
785 790 795 800
Ala Ser Ala Gly Met Glu Cys Leu Asp Gly Asp Ala Ser Phe His Ala
805 810 815
Leu Leu Arg Pro Arg Ser Ala Glu Asp Val Gly Val Leu Thr Ala Leu
820 825 830
Ala Glu Leu His Ala Gly Gly Thr Ala Ile Asp Trp Pro Thr Val Leu
835 840 845
Ala Gly Gly Arg Pro Met Asp Leu Pro Val Tyr Pro Phe Gln His Gln
850 855 860
Ser Tyr Trp Leu Val Ser Thr Asp Glu Pro Arg Thr Thr Leu Glu Leu
865 870 875 880
Val His Leu Glu Val Ala Arg Val Leu Gly Ile Thr Asp Pro Asp Thr
885 890 895
Val Leu Asp Asp Ala Ser Phe Leu Glu Leu Gly Phe Asp Ser Leu Gly
900 905 910
Gly Val Arg Leu Arg Asn Arg Leu Ala Gln Val Thr Gly Leu Thr Leu
915 920 925
Pro Pro Thr Leu Leu Phe Asp His Val Thr Pro Ala Ala Leu Ala Ala
930 935 940
Glu Leu Asp
945
<210> 149
<211> 899
<212> PRT
<213> Streptomyces rapamycinicus
<400> 149
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Val Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Val
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Ala Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val
245 250 255
Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser
275 280 285
Asn Ala Gly Leu Ser Thr Ala Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala
305 310 315 320
Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys
325 330 335
Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Asp Gly Ala Val Ala
370 375 380
Leu Val Thr Glu Asn Gln Pro Trp Pro Asp Met Gly Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Pro Thr Gln Ala Val Asp Asp Val Pro Pro Ala
420 425 430
Glu Ala Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala
435 440 445
Arg Thr Leu Pro Ala Leu Val Glu Tyr Glu Asp Arg Leu Arg Ala Tyr
450 455 460
Leu Ala Ala Ser Pro Gly Val Asp Val Arg Gly Val Ala Ser Thr Leu
465 470 475 480
Ala Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp
485 490 495
Asp Thr Val Thr Gly Thr Thr Val Ser Asp Pro Arg Val Val Phe Val
500 505 510
Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu Ala
515 520 525
Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Gly Leu
530 535 540
Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln Pro
545 550 555 560
Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp
565 570 575
Gly Val Arg Pro Asp Ala Val Val Gly His Ser Val Gly Glu Leu Ala
580 585 590
Ala Gly Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr Leu
595 600 605
Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Pro Gly Gly Val
610 615 620
Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu Gly
625 630 635 640
Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val Leu
645 650 655
Ser Gly Asp Glu Thr Ala Val Leu Gln Ala Ala Ala Ala Leu Gly Lys
660 665 670
Ser Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met Glu
675 680 685
Pro Met Leu Glu Glu Phe Arg Thr Val Ala Glu Arg Leu Thr Tyr Gln
690 695 700
Thr Pro Arg Leu Ala Met Ala Ala Gly Asp Arg Val Thr Thr Ala Glu
705 710 715 720
Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln Val
725 730 735
Ala Ser Tyr Glu Asp Ala Val Phe Ile Glu Leu Gly Ala Asp Arg Ser
740 745 750
Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Thr Asp His Glu
755 760 765
Ala Gln Ala Ala Ile Ser Ala Leu Ala His Leu Tyr Val Asn Gly Val
770 775 780
Thr Val Asp Trp Thr Ala Leu Leu Gly Asp Ala Pro Ala Thr Arg Val
785 790 795 800
Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu Gly
805 810 815
Trp Leu Ala Ala Leu Ala Pro Glu Glu Arg Ala Lys Ala Leu Leu Lys
820 825 830
Val Val Arg Asp Thr Ala Ala Thr Val Leu Gly His Ala Asp Ala Arg
835 840 845
Thr Ile Pro Val Thr Gly Ala Phe Arg Asp Leu Gly Ile Asp Ser Leu
850 855 860
Thr Ala Val Glu Leu Arg Asn Gly Leu Ala Lys Val Thr Gly Leu Arg
865 870 875 880
Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Val Leu Ala
885 890 895
Ala Arg Leu
<210> 150
<211> 924
<212> PRT
<213> Streptomyces rapamycinicus
<400> 150
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Ala Glu Ser Leu Phe
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe
50 55 60
Leu Asp Ser Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Met Glu Val
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Gly Val Ile Gln Ala Ala Leu Ser Asn
275 280 285
Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu
420 425 430
Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Ala Ala Ser Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe
500 505 510
Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp
515 520 525
Ser Ser Ile Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu
530 535 540
Arg Glu Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala
545 550 555 560
Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Met Met
565 570 575
Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala
580 585 590
Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly
595 600 605
Ala Val Ser Met Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln
610 615 620
Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu
625 630 635 640
Pro Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His
645 650 655
Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp
660 665 670
His Val Leu Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile
675 680 685
Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp
690 695 700
Glu Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Ala Pro Val Val
705 710 715 720
Pro Trp Leu Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp
725 730 735
Val Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro
740 745 750
Ala Val Gly Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val
755 760 765
Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr
770 775 780
Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr
785 790 795 800
Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala
805 810 815
Ile Leu Gly Thr Thr Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe
820 825 830
Gln His Gln Arg Tyr Trp Val Glu Trp Leu Ala Ala Leu Ala Pro Ala
835 840 845
Glu Arg Glu Lys Ala Leu Leu Lys Val Val Cys Asp Ser Ala Ala Val
850 855 860
Val Leu Gly His Ala Asp Ala Arg Thr Ile Pro Val Thr Gly Ala Phe
865 870 875 880
Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Ser
885 890 895
Leu Val Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe Asp
900 905 910
Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp
915 920
<210> 151
<211> 928
<212> PRT
<213> Streptomyces rapamycinicus
<400> 151
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Arg Ala Glu Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr
115 120 125
Gly Ala Gly Ala Ala Arg Glu Gly Tyr Gly Ala Thr Ala Ala Pro Asn
130 135 140
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu
165 170 175
Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Phe Thr Ala
260 265 270
Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
275 280 285
Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Thr Leu Lys Ser
325 330 335
Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Ser Thr Val Pro Arg Thr Leu His Val
355 360 365
Asn Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu Leu
370 375 380
Val Thr Glu Asn Gln Ser Trp Pro Val Thr Gly Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu
405 410 415
Glu Ser Ala Pro Pro Ala Gln Ser Val Asn Asn Ala Gln Pro Val Ala
420 425 430
Thr Pro Val Val Ala Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Leu Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Ala Ala Ser Pro Gly Ala Asp Met Arg Ala Val Gly Ser Thr Leu Ala
465 470 475 480
Leu Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly His Asp
485 490 495
Thr Val Thr Val Thr Gly Thr Gly Thr Ala Val Ser Asn Pro Arg Val
500 505 510
Val Phe Val Phe Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser
515 520 525
Ala Leu Arg Gly Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys
530 535 540
Ala Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu
545 550 555 560
Asp Asp Pro Ala Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser
565 570 575
Trp Ala Val Met Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val
580 585 590
Arg Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala
595 600 605
Cys Val Ala Gly Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr
610 615 620
Leu Arg Ser Gln Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala
625 630 635 640
Ser Val Ala Leu Pro Ala His Glu Ile Glu Leu Val Asp Gly Ala Trp
645 650 655
Ile Ala Ala His Asn Gly Pro Ala Ser Thr Val Val Ala Gly Ala Pro
660 665 670
Glu Ala Val Asp Arg Val Leu Ala Val His Glu Ala Arg Gly Val Arg
675 680 685
Val Arg Arg Ile Ala Val Asp Tyr Ala Ser His Thr Pro His Val Glu
690 695 700
Leu Ile Arg Asp Glu Leu Leu Asp Ile Thr Ala Gly Ile Gly Ser Gln
705 710 715 720
Ala Pro Val Val Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Glu
725 730 735
Gly Pro Leu Asp Val Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val
740 745 750
Gly Phe Asp Ser Ala Val Gly Gln Leu Arg Ala Glu Gly Asp Thr Val
755 760 765
Phe Val Glu Val Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp
770 775 780
Asp Val Val Thr Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr
785 790 795 800
Arg Met Leu Thr Ala Leu Ala Gln Ala Phe Val Glu Gly Val Thr Val
805 810 815
Asp Trp Pro Ala Ile Leu Gly Thr Ala Thr Thr Arg Val Asp Leu Pro
820 825 830
Thr Tyr Ala Phe Gln His Gln Arg Phe Trp Ala Glu Gly Trp Leu Ala
835 840 845
Arg Leu Ala Pro Val Glu Arg Glu Lys Ala Leu Leu Lys Leu Val Cys
850 855 860
Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro
865 870 875 880
Ala Thr Ala Ala Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val
885 890 895
Glu Leu Arg Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala
900 905 910
Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu
915 920 925
<210> 152
<211> 893
<212> PRT
<213> Streptomyces rapamycinicus
<400> 152
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Phe
35 40 45
Gly Pro Ala Ala Gly Asp Ser Tyr Arg Leu Gln Gly Gly Phe Leu Asp
50 55 60
Ala Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu
65 70 75 80
Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp
85 90 95
Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Thr
100 105 110
Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly
115 120 125
Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ala Val Ser Val Leu
130 135 140
Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Ile Thr
145 150 155 160
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly
165 170 175
Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
180 185 190
Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ala Arg Gln Gly
195 200 205
Gly Leu Ala Gly Asp Gly Arg Ser Lys Ala Phe Ala Asp Ser Ala Asp
210 215 220
Gly Ala Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu
225 230 235 240
Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Met Leu Arg Ser
245 250 255
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn
260 265 270
Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly
275 280 285
Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr
290 295 300
Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr Tyr Gly
305 310 315 320
Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Val Lys Ser Asn Leu
325 330 335
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
340 345 350
Met Ala Leu Gln Arg Gly Phe Val Pro Arg Thr Leu His Val Asp Glu
355 360 365
Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Ala Leu Val Thr
370 375 380
Glu Asn Gln Pro Trp Pro Asp Met Gly Arg Ala Arg Arg Ala Gly Val
385 390 395 400
Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
405 410 415
Ala Pro Pro Thr Gln Pro Ala Asp Asn Ala Val Ile Glu Arg Ala Pro
420 425 430
Glu Trp Leu Pro Met Val Ile Ser Ala Arg Thr Gln Ser Ala Leu Thr
435 440 445
Glu His Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly Val
450 455 460
Asp Met Arg Ala Val Ala Ser Thr Leu Ala Met Thr Arg Ser Val Phe
465 470 475 480
Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala
485 490 495
Ala Thr Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln
500 505 510
Arg Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala
515 520 525
Arg Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu
530 535 540
Val Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Leu Gln Val
545 550 555 560
Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val
565 570 575
Val Gly His Ser Val Gly Glu Leu Ala Ala Gly Tyr Val Ser Gly Leu
580 585 590
Trp Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu
595 600 605
Met Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser
610 615 620
Glu Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala
625 630 635 640
Val Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val
645 650 655
Leu Gln Ala Ala Glu Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser
660 665 670
His Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg
675 680 685
Thr Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Gln Val Ser Met Ala
690 695 700
Ala Gly Asp Gln Val Thr Thr Thr Glu Tyr Trp Val Arg Gln Val Arg
705 710 715 720
Asp Thr Val Arg Phe Gly Glu Gln Val Ala Ser Tyr Glu Asp Ala Val
725 730 735
Phe Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly
740 745 750
Val Ala Met Leu His Gly Asp His Glu Ala Gln Ala Ala Val Ser Ala
755 760 765
Leu Ala His Leu Tyr Val Asn Gly Val Thr Val Asp Trp Pro Ala Leu
770 775 780
Leu Gly Asp Ala Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe
785 790 795 800
Gln His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala
805 810 815
Pro Glu Glu Arg Ala Lys Ala Leu Val Lys Val Val Cys Asp Ser Ala
820 825 830
Ala Thr Val Leu Gly His Ala Asp Val Asp Ser Ile Pro Val Thr Ala
835 840 845
Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
850 855 860
Asn Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
865 870 875 880
Phe Asp Tyr Pro Thr Pro Gly Ala Leu Ala Ala Arg Leu
885 890
<210> 153
<211> 901
<212> PRT
<213> Streptomyces rapamycinicus
<400> 153
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Ser
35 40 45
Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe Leu
50 55 60
Ala Thr Ala Ala Asn Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg
65 70 75 80
Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser
85 90 95
Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly
100 105 110
Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly Tyr Gly Ile
115 120 125
Gly Ala Asp Leu Glu Gly Tyr Gly Ala Thr Ala Gly Leu Asn Val Leu
130 135 140
Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Val Thr
145 150 155 160
Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly
165 170 175
Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Ile Gly Gly Val
180 185 190
Thr Val Met Ala Thr Pro His Thr Phe Val Glu Phe Ser Arg Gln Arg
195 200 205
Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp
210 215 220
Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu
225 230 235 240
Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser
245 250 255
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro Asn
260 265 270
Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly
275 280 285
Leu Thr Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr
290 295 300
Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly
305 310 315 320
Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Val Lys Ser Asn Val
325 330 335
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
340 345 350
Met Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu
355 360 365
Pro Ser Arg His Val Asp Trp Thr Asp Gly Ala Val Glu Leu Val Thr
370 375 380
Glu Asn Gln Ser Trp Pro Glu Ala Gly Arg Pro Arg Arg Ala Gly Val
385 390 395 400
Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser
405 410 415
Ala Pro Pro Thr Gln Ala Val Asp Asp Val Arg Pro Ala Asp Ala Pro
420 425 430
Val Val Ala Ser Val Met Ala Ser Glu Leu Val Pro Leu Val Ile Ser
435 440 445
Ala Lys Thr Gln Ser Ala Leu Ala Glu Tyr Glu Gly Arg Leu Arg Ala
450 455 460
Tyr Leu Ala Ala Ser Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr
465 470 475 480
Leu Ala Met Thr Arg Ser Val Phe Glu His Arg Ala Val Ile Val Gly
485 490 495
Asp Asp Thr Val Ser Gly Thr Ala Ala Thr Asp Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Ala Glu Leu
515 520 525
Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp
530 535 540
Leu Leu Asp Val Pro Asp Leu Glu Val Asn Glu Thr Gly Tyr Ala Gln
545 550 555 560
Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser
565 570 575
Trp Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu
580 585 590
Ala Ala Ala Tyr Val Ser Gly Leu Trp Ser Leu Glu Asp Ala Cys Thr
595 600 605
Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly
610 615 620
Val Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu
625 630 635 640
Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val
645 650 655
Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Ala Ala Glu Gly Leu Gly
660 665 670
Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met
675 680 685
Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Gln Gly Leu Thr Tyr
690 695 700
His Ala Pro Gly Val Val Met Ala Ala Gly Asp Arg Val Met Thr Ala
705 710 715 720
Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln
725 730 735
Val Ala Ser Tyr Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg
740 745 750
Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His
755 760 765
Glu Thr Gln Ala Ala Ile Gly Ala Leu Ala His Leu Tyr Val Asn Gly
770 775 780
Val Thr Val Asp Trp Thr Ala Leu Leu Gly Asp Val Pro Val Thr Arg
785 790 795 800
Val Asp Leu Pro Thr Tyr Ala Phe Gln Gln Gln Arg Tyr Trp Ala Glu
805 810 815
Arg Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg Glu Lys Ala Leu Leu
820 825 830
Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp Thr
835 840 845
Ser Thr Ile Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Ile Asp Ser
850 855 860
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu Leu
865 870 875 880
Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu
885 890 895
Ala Ala Arg Leu Asp
900
<210> 154
<211> 924
<212> PRT
<213> Streptomyces rapamycinicus
<400> 154
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Pro Gly Lys Ser Tyr Ser Val Gln Gly Gly
50 55 60
Phe Leu Asp Ala Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Met Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ile Gly Ala Asp Leu Gly Gly Phe Gly Thr Thr Ala Gly Ala Ala
130 135 140
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro
145 150 155 160
Ala Phe Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His
165 170 175
Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val
180 185 190
Gly Gly Val Thr Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser
195 200 205
Arg Gln Arg Gly Leu Ser Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp
210 215 220
Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val
225 230 235 240
Glu Arg Leu Ser Asp Ala Gln Ala Asn Gly His Gln Ile Leu Ala Val
245 250 255
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser
260 265 270
Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser
275 280 285
Asn Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly
290 295 300
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala
305 310 315 320
Thr Tyr Gly Gln Gly Arg Gly Glu Pro Leu Leu Leu Gly Ser Leu Lys
325 330 335
Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
340 345 350
Lys Met Val Met Ala Leu Gln His Ser Met Val Pro Arg Thr Leu His
355 360 365
Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Glu
370 375 380
Leu Val Ala Glu Asn Gln Pro Trp Pro Glu Thr Gly Arg Pro Arg Arg
385 390 395 400
Ala Gly Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile
405 410 415
Leu Glu Ser Ala Pro Ala Gln Ser Val Gly Asp Thr Ala Gly Ser Thr
420 425 430
Pro Val Leu Val Ser Glu Leu Val Pro Leu Val Ile Ser Ala Lys Thr
435 440 445
Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala
450 455 460
Ala Ser Pro Gly Val Asp Ile Arg Ala Val Ala Ser Thr Leu Ala Val
465 470 475 480
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Glu Thr
485 490 495
Val Thr Gly Thr Ala Val Ser Asp Pro Arg Ile Val Phe Val Phe Pro
500 505 510
Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser
515 520 525
Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser
530 535 540
Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala Val
545 550 555 560
Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val
565 570 575
Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val
580 585 590
Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala
595 600 605
Val Ser Met Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln Ala
610 615 620
Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro
625 630 635 640
Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His Asn
645 650 655
Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp His
660 665 670
Val Leu Thr Ala His Glu Ala Gln Gly Val Arg Val Arg Arg Ile Thr
675 680 685
Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu
690 695 700
Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Thr Pro Leu Val Pro
705 710 715 720
Trp Leu Ser Thr Val Asp Gly Thr Trp Val Asp Ser Pro Leu Asp Gly
725 730 735
Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala
740 745 750
Val Ser Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val Ser
755 760 765
Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr Val
770 775 780
Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr Ala
785 790 795 800
Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Arg Ala Val
805 810 815
Leu Gly Asp Val Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe
820 825 830
Gln His Gln Arg Tyr Trp Ala Glu Ala Trp Leu Val Gly Leu Ala Pro
835 840 845
Glu Glu Arg Ala Lys Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala
850 855 860
Thr Val Leu Gly His Ala Asp Ala Arg Ser Ile Pro Ala Thr Gly Ala
865 870 875 880
Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg Asn
885 890 895
Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Val Phe
900 905 910
Asp Tyr Pro Thr Pro Ala Asp Leu Ala Ala Arg Leu
915 920
<210> 155
<211> 922
<212> PRT
<213> Streptomyces rapamycinicus
<400> 155
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Met Ala Gly Lys Ser His Arg Ala Glu Gly Gly Phe Leu Asp Ala
50 55 60
Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala
65 70 75 80
Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu
85 90 95
Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Ser Asp
100 105 110
Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ala Gly Ala
115 120 125
Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser Val Leu Ser
130 135 140
Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val
145 150 155 160
Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr
165 170 175
Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr
180 185 190
Val Met Ala Thr Pro Glu Leu Phe Thr Glu Phe Ser Arg Gln Arg Gly
195 200 205
Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly
210 215 220
Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser
225 230 235 240
Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val Arg Ser Ser
245 250 255
Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly
260 265 270
Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn Ala Gly Leu
275 280 285
Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr
290 295 300
Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly Gln
305 310 315 320
Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser Asn Ile Gly
325 330 335
His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys Met Val Met
340 345 350
Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val Asp Glu Pro
355 360 365
Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu Val Arg Glu
370 375 380
Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala Gly Val Ser
385 390 395 400
Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala
405 410 415
Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu Thr Pro Val
420 425 430
Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys Thr Gln Pro
435 440 445
Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu Ala Ala Ser
450 455 460
Pro Gly Val Asp Thr Arg Ala Val Ala Ser Thr Leu Ala Val Thr Arg
465 470 475 480
Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr
485 490 495
Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe Val Phe Pro Gly Gln
500 505 510
Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp Ser Ser Val
515 520 525
Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu Ser Glu Phe
530 535 540
Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala Val Val Asp
545 550 555 560
Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met Val Ser Leu
565 570 575
Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala Val Ile Gly
580 585 590
His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Val Ser
595 600 605
Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln Ala Ile Ala
610 615 620
Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu Pro Ala Gln
625 630 635 640
Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His Asn Gly Pro
645 650 655
Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp His Val Leu
660 665 670
Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile Thr Val Asp
675 680 685
Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp Glu Leu Leu
690 695 700
Asp Ile Thr Ser Asp Ser Ser Ser Gln Ala Pro Leu Val Pro Trp Leu
705 710 715 720
Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp Gly Glu Tyr
725 730 735
Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro Ala Val Gly
740 745 750
Gln Leu Gln Ala Glu Gly Asp Thr Val Phe Val Glu Val Ser Ala Ser
755 760 765
Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr Val Ala Thr
770 775 780
Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr Ala Leu Ala
785 790 795 800
Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala Ile Leu Gly
805 810 815
Thr Ala Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln
820 825 830
Arg Tyr Trp Leu Arg Ser Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg
835 840 845
Glu Lys Ala Leu Leu Lys Leu Val Cys Asp Ser Ala Ala Met Val Leu
850 855 860
Gly His Ala Asp Ala Arg Ser Ile Pro Ala Ala Gly Ala Phe Lys Asp
865 870 875 880
Leu Gly Val Asp Ser Leu Met Ala Val Glu Leu Arg Asn Gly Leu Val
885 890 895
Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro
900 905 910
Thr Pro Thr Val Leu Ala Ala Arg Leu Asp
915 920
<210> 156
<211> 926
<212> PRT
<213> Streptomyces rapamycinicus
<400> 156
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Ser Asp Pro Glu Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Phe Pro Val Gly Tyr
115 120 125
Gly Ala Gly Phe Asp Arg Glu Gly Tyr Gly Ala Thr Ser Gly Pro Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Val Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Met Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu
165 170 175
Ala Ala Gln Ala Leu Arg Asn Gly Glu Cys Ser Met Ala Leu Ala Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Glu Val Phe Thr Glu Phe Ala Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Ala Gly Phe Ser Glu Gly Ala Gly Leu Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser Asn
275 280 285
Ala Gly Leu Ser Thr Ala Asp Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Thr Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Arg His Gly Phe Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Val Leu
405 410 415
Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Glu Gln Pro Val Glu
420 425 430
Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Ala Ala Ser Pro Gly Ala Asp Thr Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Ala Val Thr Gly Thr Ala Val Thr Asp Pro Arg Val Val Phe Val Phe
500 505 510
Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp
515 520 525
Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu
530 535 540
Ser Glu Phe Val Asp Trp Asp Leu Phe Ala Val Leu Asp Asp Pro Ala
545 550 555 560
Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Val Met
565 570 575
Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala
580 585 590
Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly
595 600 605
Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln
610 615 620
Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu
625 630 635 640
Pro Ala His Glu Ile Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His
645 650 655
Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp
660 665 670
His Val Leu Thr Ala His Glu Ala Arg Gly Val Arg Val Arg Arg Ile
675 680 685
Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp
690 695 700
Glu Leu Leu Gly Ile Thr Ala Gly Ile Gly Ser Gln Pro Pro Val Val
705 710 715 720
Pro Trp Leu Ser Thr Val Asp Gly Ser Trp Val Asp Ser Pro Leu Asp
725 730 735
Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro
740 745 750
Ala Val Ser Gln Leu Gln Ala Gln Gly Asp Ala Val Phe Val Glu Val
755 760 765
Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr
770 775 780
Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr
785 790 795 800
Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala
805 810 815
Ile Leu Gly Thr Thr Thr Ala Arg Val Leu Asp Leu Pro Thr Tyr Ala
820 825 830
Phe Gln His Gln Arg Tyr Trp Val Lys Ser Trp Leu Ala Ala Leu Ala
835 840 845
Pro Glu Glu Arg Ala Lys Ala Leu Leu Arg Val Val Cys Asp Ser Ala
850 855 860
Ala Thr Val Leu Gly His Ala Asp Ile Asp Ser Ile Pro Val Thr Ala
865 870 875 880
Ala Phe Lys Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu Arg
885 890 895
Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
900 905 910
Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala Ala Arg Leu Asp
915 920 925
<210> 157
<211> 902
<212> PRT
<213> Streptomyces rapamycinicus
<400> 157
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Asp Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Pro Asp Pro Asp Ala Ser Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Ser Ala Gly Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu
85 90 95
Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Leu
100 105 110
Arg Gly Ser Asp Thr Gly Val Phe Ile Gly Ala Tyr Pro Gly Gly Tyr
115 120 125
Gly Ala Gly Ala Gly Ala Asp Leu Glu Gly Tyr Gly Thr Thr Ser Gly
130 135 140
Pro Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly
145 150 155 160
Pro Ala Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Gln Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu
180 185 190
Val Gly Gly Val Thr Val Met Ala Thr Pro Asp Val Phe Thr Glu Phe
195 200 205
Ala Arg Gln Arg Gly Leu Ala Thr Asp Gly Arg Ser Lys Ala Phe Ala
210 215 220
Asp Ser Ala Asp Gly Ala Gly Phe Ser Glu Gly Ile Gly Val Leu Leu
225 230 235 240
Val Glu Arg Leu Ser Asp Ala Glu Ala Lys Gly His Gln Val Leu Ala
245 250 255
Val Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Thr Ala Leu
275 280 285
Ser Asn Ala Gly Leu Thr Thr Ala Glu Val Asp Val Val Glu Gly His
290 295 300
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile
305 310 315 320
Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val
340 345 350
Ile Lys Met Val Met Ala Leu Arg His Ala Leu Val Pro Arg Thr Leu
355 360 365
His Val Asp Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val
370 375 380
Glu Leu Val Thr Glu Asn Gln Pro Trp Pro Glu Ile Gly Arg Pro Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val
405 410 415
Ile Leu Glu Ser Ala Pro Pro Thr Gln Ala Glu Asp Ala Ala Gln Pro
420 425 430
Val Glu Ala Pro Val Met Gly Ser Glu Pro Val Pro Leu Val Ile Ser
435 440 445
Ala Lys Thr Leu Pro Ala Leu Asn Ala His Glu Asp Arg Leu Arg Ala
450 455 460
Tyr Leu Ala Ala Ser Pro Gly Val Asp Met Arg Ala Val Ala Ser Thr
465 470 475 480
Leu Ala Met Thr Arg Ser Met Phe Glu His Arg Gly Val Leu Leu Gly
485 490 495
Asp Gly Thr Val Ser Gly Thr Ala Val Ser Asp Pro Arg Val Val Phe
500 505 510
Val Phe Pro Gly Gln Gly Ser Gln Arg Ala Gly Met Gly Glu Glu Leu
515 520 525
Ala Ala Ala Phe Pro Val Phe Ala Arg Ile His Gln Gln Val Trp Asp
530 535 540
Leu Leu Asp Val Pro Asp Leu Asp Val Asn Glu Thr Gly Tyr Ala Gln
545 550 555 560
Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser
565 570 575
Trp Gly Val Arg Pro Asp Ala Val Ile Gly His Ser Val Gly Glu Leu
580 585 590
Ala Ala Ala Tyr Val Ser Gly Val Trp Ser Leu Glu Asp Ala Cys Thr
595 600 605
Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly
610 615 620
Val Met Val Ala Val Pro Val Ser Glu Asp Glu Ala Arg Ala Val Leu
625 630 635 640
Gly Glu Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ser Ser Val Val
645 650 655
Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Ala Ala Glu Gly Leu Gly
660 665 670
Lys Trp Thr Arg Leu Ala Thr Ser His Ala Phe His Ser Ala Arg Met
675 680 685
Glu Pro Met Leu Glu Glu Phe Arg Ala Val Ala Glu Gly Leu Thr Tyr
690 695 700
Arg Thr Pro Gln Val Ala Met Ala Ala Gly Asp Gln Val Met Thr Ala
705 710 715 720
Glu Tyr Trp Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Glu Gln
725 730 735
Val Ala Ser Phe Glu Asp Ala Val Phe Val Glu Leu Gly Ala Asp Arg
740 745 750
Ser Leu Ala Arg Leu Val Asp Gly Val Ala Met Leu His Gly Asp His
755 760 765
Glu Ala Gln Ala Ala Val Gly Ala Leu Ala His Leu Tyr Val Asn Gly
770 775 780
Val Ser Val Glu Trp Ser Ala Val Leu Gly Asp Val Pro Val Thr Arg
785 790 795 800
Val Asp Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Leu Glu
805 810 815
Gly Arg Trp Leu Ala Ala Leu Ala Pro Ala Glu Arg Glu Lys Ala Leu
820 825 830
Leu Lys Leu Val Ser Asp Gly Ala Ala Thr Val Leu Gly His Ala Asp
835 840 845
Thr Ser Thr Ile Pro Ala Thr Thr Ala Phe Lys Asp Leu Gly Ile Asn
850 855 860
Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Glu
865 870 875 880
Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro Ala Ala
885 890 895
Leu Ala Ala Arg Leu Asp
900
<210> 158
<211> 892
<212> PRT
<213> Streptomyces rapamycinicus
<400> 158
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Leu Glu Ser Gly Thr Asp Ala
20 25 30
Val Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Asn Leu Tyr
35 40 45
Asp Met Ala Gly Lys Ser His Arg Ala Glu Gly Gly Phe Leu Asp Ala
50 55 60
Ala Ala Gly Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala
65 70 75 80
Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val Ser Trp Glu
85 90 95
Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Ser Asp
100 105 110
Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile Gly Ala
115 120 125
Asp Leu Gly Gly Phe Gly Ala Thr Ala Ser Ser Val Ser Val Leu Ser
130 135 140
Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Phe Thr Val
145 150 155 160
Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Tyr
165 170 175
Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr
180 185 190
Val Met Ala Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Gly Gly
195 200 205
Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly
210 215 220
Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser
225 230 235 240
Asp Ala Arg Arg Asn Gly His Gln Val Leu Ala Val Val Arg Gly Ser
245 250 255
Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly
260 265 270
Pro Ser Gln Gln Arg Val Ile Arg Ala Ala Leu Ser Asn Ala Gly Leu
275 280 285
Ser Thr Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr
290 295 300
Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr Tyr Gly Gln
305 310 315 320
Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Val Lys Ser Asn Leu Gly
325 330 335
His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val Met
340 345 350
Ala Leu Gln His Gly Leu Val Pro Arg Thr Leu His Val Asp Glu Pro
355 360 365
Ser Arg His Val Asp Trp Ser Ala Gly Ala Val Gln Leu Val Thr Glu
370 375 380
Asn Gln Pro Trp Pro Asp Met Gly Arg Ala Arg Arg Ala Gly Val Ser
385 390 395 400
Ser Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala
405 410 415
Pro Pro Thr Gln Pro Ala Asp Asn Ala Val Ile Glu Arg Ala Pro Glu
420 425 430
Trp Val Pro Leu Val Ile Ser Ala Arg Thr Gln Ser Ala Leu Thr Glu
435 440 445
His Glu Gly Arg Leu Arg Ala Tyr Leu Ala Ala Ser Pro Gly Val Asp
450 455 460
Met Arg Ala Val Ala Ser Thr Leu Ala Met Thr Arg Ser Val Phe Glu
465 470 475 480
His Arg Ala Val Leu Leu Gly Asp Asp Thr Val Thr Gly Thr Ala Val
485 490 495
Ser Asp Pro Arg Ala Val Phe Val Phe Pro Gly Gln Gly Ser Gln Arg
500 505 510
Ala Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Val Phe Ala Arg
515 520 525
Ile His Gln Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Glu Val
530 535 540
Asn Glu Thr Gly Tyr Ala Gln Pro Ala Leu Phe Ala Met Gln Val Ala
545 550 555 560
Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Asp Ala Val Ile
565 570 575
Gly His Ser Val Gly Glu Leu Ala Ala Ala Tyr Val Ser Gly Val Trp
580 585 590
Ser Leu Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met
595 600 605
Gln Ala Leu Pro Ala Gly Gly Val Met Val Ala Val Pro Val Ser Glu
610 615 620
Asp Glu Ala Arg Ala Val Leu Gly Glu Gly Val Glu Ile Ala Ala Val
625 630 635 640
Asn Gly Pro Ser Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu
645 650 655
Gln Ala Ala Glu Gly Leu Gly Lys Trp Thr Arg Leu Ala Thr Ser His
660 665 670
Ala Phe His Ser Ala Arg Met Glu Pro Met Leu Glu Glu Phe Arg Ala
675 680 685
Val Ala Glu Gly Leu Thr Tyr Arg Thr Pro Gln Val Ser Met Ala Val
690 695 700
Gly Asp Gln Val Thr Thr Ala Glu Tyr Trp Val Arg Gln Val Arg Asp
705 710 715 720
Thr Val Arg Phe Gly Glu Gln Val Ala Ser Tyr Glu Asp Ala Val Phe
725 730 735
Val Glu Leu Gly Ala Asp Arg Ser Leu Ala Arg Leu Val Asp Gly Val
740 745 750
Ala Met Leu His Gly Asp His Glu Ile Gln Ala Ala Ile Gly Ala Leu
755 760 765
Ala His Leu Tyr Val Asn Gly Val Thr Val Asp Trp Pro Ala Leu Leu
770 775 780
Gly Asp Ala Pro Ala Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe Gln
785 790 795 800
His Gln Arg Tyr Trp Leu Glu Gly Arg Trp Leu Ala Ala Leu Ala Pro
805 810 815
Ala Glu Arg Glu Asp Ala Leu Leu Lys Leu Val Arg Asp Ser Ala Ala
820 825 830
Leu Val Leu Gly His Ala Asp Ala Ser Thr Ile Pro Ala Ala Ala Ala
835 840 845
Phe Lys Asp Leu Gly Ile Asp Ser Leu Thr Ala Val Glu Leu Arg Asn
850 855 860
Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Asn Thr Thr Val Phe
865 870 875 880
Asp Tyr Pro Thr Pro Ala Ile Leu Ala Thr Arg Leu
885 890
<210> 159
<211> 924
<212> PRT
<213> Streptomyces rapamycinicus
<400> 159
Glu Pro Leu Ala Val Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Ala Asp Arg Gly Trp Asp Ala Glu Ser Leu Phe
35 40 45
Asp Pro Asp Pro Ala Val Gly Lys Ser Tyr Cys Val Glu Gly Gly Phe
50 55 60
Leu Asp Ser Ala Ala Ser Phe Asp Ala Gly Phe Phe Gly Ile Ser Pro
65 70 75 80
Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Ile Met Glu Val
85 90 95
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg
100 105 110
Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Ala Gly Gly Tyr Gly
115 120 125
Ala Gly Ala Asp Leu Gly Gly Phe Ala Ala Thr Ala Ser Ala Thr Ser
130 135 140
Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala
145 150 155 160
Ile Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln
165 170 175
Ala Gly Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly
180 185 190
Gly Val Thr Val Met Ala Thr Pro Gln Ser Phe Val Glu Phe Ser Arg
195 200 205
Gln Arg Gly Leu Ala Ser Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser
210 215 220
Ala Asp Gly Thr Gly Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu
225 230 235 240
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Gln Val Leu Ala Val Val
245 250 255
Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala
260 265 270
Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Gln Ala Ala Leu Ser Asn
275 280 285
Ala Gly Leu Ala Ala His Glu Val Asp Val Val Glu Ala His Gly Thr
290 295 300
Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Ile Ala Thr
305 310 315 320
Tyr Gly Gln Asp Arg Glu Arg Pro Leu Leu Leu Gly Ser Leu Lys Ser
325 330 335
Asn Ile Gly His Ala Gln Ala Ala Ser Gly Val Ser Gly Val Ile Lys
340 345 350
Met Val Met Ala Leu Gln His Asn Thr Val Pro Arg Thr Leu His Val
355 360 365
Asp Glu Pro Ser Arg His Val Asp Trp Ala Ala Gly Ala Val Glu Leu
370 375 380
Val Arg Glu Asn Gln Pro Trp Pro Gly Thr Asp Arg Pro Arg Arg Ala
385 390 395 400
Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His Val Ile Leu
405 410 415
Glu Ser Ala Pro Pro Ala Gln Pro Ala Glu Glu Ala Gln Pro Val Glu
420 425 430
Thr Pro Val Val Ala Ser Asp Val Leu Pro Leu Val Ile Ser Ala Lys
435 440 445
Thr Gln Pro Ala Leu Thr Glu His Glu Asp Arg Leu Arg Ala Tyr Leu
450 455 460
Ala Ala Ser Pro Gly Ala Asp Ile Arg Ala Val Ala Ser Thr Leu Ala
465 470 475 480
Val Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Asp Asp
485 490 495
Thr Val Thr Gly Thr Ala Val Thr Asp Pro Arg Ile Val Phe Val Phe
500 505 510
Pro Gly Gln Gly Trp Gln Trp Leu Gly Met Gly Ser Ala Leu Arg Asp
515 520 525
Ser Ser Val Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala Leu
530 535 540
Arg Glu Phe Val Asp Trp Asp Leu Phe Thr Val Leu Asp Asp Pro Ala
545 550 555 560
Val Val Asp Arg Val Asp Val Val Gln Pro Ala Ser Trp Ala Met Met
565 570 575
Val Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg Pro Asp Ala
580 585 590
Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Val Ala Gly
595 600 605
Ala Val Ser Leu Arg Asp Ala Ala Arg Ile Val Thr Leu Arg Ser Gln
610 615 620
Ala Ile Ala Gly Leu Ala Gly Arg Gly Ala Met Ala Ser Val Ala Leu
625 630 635 640
Pro Ala Gln Asp Val Glu Leu Val Asp Gly Ala Trp Ile Ala Ala His
645 650 655
Asn Gly Pro Ala Ser Thr Val Ile Ala Gly Thr Pro Glu Ala Val Asp
660 665 670
His Val Leu Thr Ala His Glu Ala Gln Gly Val Arg Val Arg Arg Ile
675 680 685
Thr Val Asp Tyr Ala Ser His Thr Pro His Val Glu Leu Ile Arg Asp
690 695 700
Glu Leu Leu Asp Ile Thr Ser Asp Ser Ser Ser Gln Thr Pro Leu Val
705 710 715 720
Pro Trp Leu Ser Thr Val Asp Gly Thr Trp Val Asp Ser Pro Leu Asp
725 730 735
Gly Glu Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Gly Phe His Pro
740 745 750
Ala Val Ser Gln Leu Gln Ala Gln Gly Asp Thr Val Phe Val Glu Val
755 760 765
Ser Ala Ser Pro Val Leu Leu Gln Ala Met Asp Asp Asp Val Val Thr
770 775 780
Val Ala Thr Leu Arg Arg Asp Asp Gly Asp Ala Thr Arg Met Leu Thr
785 790 795 800
Ala Leu Ala Gln Ala Tyr Val His Gly Val Thr Val Asp Trp Pro Ala
805 810 815
Ile Leu Gly Thr Thr Thr Thr Arg Val Asp Leu Pro Thr Tyr Ala Phe
820 825 830
Gln His Gln Arg Tyr Trp Leu Lys Ser Arg Leu Thr Gly Arg Thr Ser
835 840 845
Val Glu Gln His Arg Ile Met Leu Glu Leu Val Leu Gly Glu Ala Ala
850 855 860
Ser Val Leu Gly His Ser Ser Ala Asp Ala Ile Ala Thr Asp Thr Ser
865 870 875 880
Phe Lys Asp Leu Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn
885 890 895
Arg Leu Val Ala Glu Thr Gly Leu Gln Leu Pro Ala Thr Met Val Phe
900 905 910
Asp Tyr Pro Thr Ala Asn Ala Leu Ala Ala His Leu
915 920
<210> 160
<211> 966
<212> PRT
<213> Streptomyces rapamycinicus
<400> 160
Glu Pro Ile Ala Ile Val Ala Met Ala Cys Arg Leu Pro Gly Gly Val
1 5 10 15
Ser Ser Pro Glu Gly Leu Trp His Leu Val Glu Ser Gly Thr Asp Ala
20 25 30
Ile Ser Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Glu Gly Leu Phe
35 40 45
Asp Pro Asp Pro Asp Ala Ala Gly Lys Ser Tyr Cys Val Gln Gly Gly
50 55 60
Phe Leu Asp Thr Ala Ala Asp Phe Asp Ala Pro Phe Phe Gly Ile Ser
65 70 75 80
Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln Arg Leu Leu Leu Glu
85 90 95
Thr Thr Trp Glu Ala Ile Glu Arg Ala Gln Ile Asp Pro Lys Ser Leu
100 105 110
Arg Gly Arg Asp Val Gly Val Tyr Val Gly Gly Ala Ala Gln Gly Tyr
115 120 125
Gly Val Gly Val Asp Gln Gln His Asp Asn Gly Ile Thr Gly Ser Ser
130 135 140
Val Ser Leu Leu Ser Gly Arg Val Ser Tyr Ala Leu Gly Leu Glu Gly
145 150 155 160
Pro Gly Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
165 170 175
His Leu Ala Ser Gln Ala Leu Arg Gln Arg Glu Cys Ser Leu Ala Leu
180 185 190
Val Ser Gly Val Ser Val Met Ser Ser Pro Ala Met Phe Val Glu Phe
195 200 205
Ser Arg Gln Arg Gly Leu Ser Ser Asp Gly Arg Cys Lys Ser Phe Ala
210 215 220
Ala Ser Ala Asp Gly Thr Ile Trp Ser Glu Gly Val Gly Val Leu Val
225 230 235 240
Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Arg Val Leu Ala
245 250 255
Thr Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn Gly Leu
260 265 270
Thr Ala Pro Asn Gly Thr Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
275 280 285
Ala Asn Ala Gly Leu Thr Ala Ser Asp Val Asp Val Val Glu Ala His
290 295 300
Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu Ala Glu Ala Ile Leu
305 310 315 320
Ala Thr Tyr Gly Gln Glu Arg Ser Ala Pro Ala Trp Leu Gly Ser Leu
325 330 335
Lys Ser Asn Ile Gly His Ala Met Ala Ala Ser Gly Val Leu Ser Val
340 345 350
Ile Lys Met Val Glu Ala Met Gly His Gly Ser Leu Pro Arg Thr Leu
355 360 365
His Val Asp Ala Pro Ser Pro His Val Asp Trp Thr Ser Gly Ser Val
370 375 380
Ala Leu Leu Thr Glu His Gln Pro Trp Pro Asp Asp Thr Lys Leu Arg
385 390 395 400
Arg Ala Gly Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val
405 410 415
Val Leu Glu Gln Tyr Gln Ala Pro Ala Pro Pro Val Thr Pro Val Thr
420 425 430
Pro Ala Pro Pro Thr Pro Val Thr Pro Val Thr Pro Asn Glu Pro Gly
435 440 445
Pro Leu Pro Trp Val Leu Ser Ala Gln Ser Pro Lys Ala Leu Arg Glu
450 455 460
Gln Ala Gly Arg Leu Tyr Ala Ser Leu Ala Gly Asp Ser Glu Trp Asn
465 470 475 480
Ser Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser Asp Phe Ala
485 490 495
His Arg Ala Val Ala Val Gly Ser Gly Arg Glu Phe Leu Arg Ala Leu
500 505 510
Ser Lys Leu Ala Asp Gly Ala Pro Trp Pro Gly Leu Thr Thr Ala Thr
515 520 525
Ala Thr Ala Lys Ala Arg Arg Val Ala Phe Leu Phe Asp Gly Gln Gly
530 535 540
Thr Gln Arg Leu Gly Met Gly Lys Glu Leu Tyr Asp Ser Tyr Pro Ala
545 550 555 560
Phe Ala Arg Ala Trp Asp Thr Val Ser Ala Gly Phe Asp Lys His Leu
565 570 575
Asp His Ser Leu Thr Asp Val Cys Phe Gly Glu Gly Gly Ser Thr Thr
580 585 590
Ala Gly Leu Val Asp Asp Thr Leu Tyr Ala Gln Ala Gly Ile Phe Ala
595 600 605
Met Glu Ala Ala Leu Phe Gly Leu Leu Glu Asp Trp Gly Val Arg Pro
610 615 620
Asp Phe Val Ala Gly His Ser Ile Gly Glu Ala Thr Ala Ala Tyr Ala
625 630 635 640
Ser Gly Met Leu Ser Leu Glu Asn Val Thr Thr Leu Ile Val Ala Arg
645 650 655
Gly Arg Ala Leu Arg Thr Thr Pro Pro Gly Ala Met Val Ala Leu Arg
660 665 670
Ala Gly Glu Glu Glu Val Arg Glu Phe Leu Ser Arg Thr Gly Ala Ala
675 680 685
Leu Asp Leu Ala Ala Val Asn Ser Pro Glu Ala Val Val Val Ser Gly
690 695 700
Glu Pro Glu Pro Val Ala Asp Phe Glu Ala Ala Trp Thr Ala Ser Gly
705 710 715 720
Arg Glu Ala Arg Lys Leu Lys Val Arg His Ala Phe His Ser Arg His
725 730 735
Val Glu Ala Val Leu Asp Glu Phe Arg Thr Ala Leu Glu Ser Leu Lys
740 745 750
Phe Arg Ala Pro Ala Leu Pro Val Val Ser Thr Val Thr Gly Arg Leu
755 760 765
Ile Asp Gln Asp Glu Met Gly Thr Pro Glu Tyr Trp Leu Arg Gln Val
770 775 780
Arg Arg Pro Val Arg Phe Gln Asp Ala Val Arg Glu Leu Ala Glu Gln
785 790 795 800
Gly Val Gly Thr Phe Val Glu Val Gly Pro Ser Gly Ala Leu Ala Ser
805 810 815
Ala Gly Val Glu Cys Leu Gly Gly Asp Ala Ser Phe His Ala Val Leu
820 825 830
Arg Pro Arg Ser Pro Glu Asp Val Cys Leu Met Thr Ala Ile Ala Glu
835 840 845
Leu His Ala Gly Gly Thr Ala Ile Asp Trp Ala Lys Val Leu Ser Gly
850 855 860
Gly Arg Ala Val Asp Leu Pro Val Tyr Pro Phe Gln His Gln Ser Tyr
865 870 875 880
Trp Leu Ala Pro Ala Glu Pro Ser Tyr Ala Asp Glu Pro Arg Thr Met
885 890 895
Leu Glu Leu Val His Met Glu Val Ala Ser Leu Leu Gly Met Ala Asp
900 905 910
Pro Gly Val Ile Leu Asp Asp Ser Ser Phe Leu Glu Leu Gly Phe Asp
915 920 925
Ser Leu Ser Ala Val Arg Leu Arg Asn Arg Leu Ser Lys Ala Thr Gly
930 935 940
Leu Asp Leu Pro Ser Thr Leu Leu Phe Glu His Pro Thr Ser Ala Glu
945 950 955 960
Leu Ala Ala His Leu Asp
965
<210> 161
<211> 1297
<212> PRT
<213> Streptomyces violaceusniger
<400> 161
Met Ser Arg Ala Glu Leu Val Arg Pro Ile Tyr Asp Leu Leu Arg Ala
1 5 10 15
Asn Ala Glu Arg Leu Gly Asp Lys Met Ala Tyr Val Asp Ser Arg Leu
20 25 30
Ala Leu Thr His Ala Glu Leu Ala Ala Arg Thr Gly Arg Ile Ala Gly
35 40 45
His Leu Val Asp Met Gly Val Asp Arg Gly Asp Arg Val Ala Ile Leu
50 55 60
Leu Gly Asn Arg Val Glu Asn Ile Glu Ser Tyr Leu Ala Ile Ala Arg
65 70 75 80
Ala Ser Ala Val Ala Val Pro Leu Asn Pro Asp Ala Thr Glu Ala Glu
85 90 95
Val Ala His Phe Leu Ser Asp Ser Gly Ala Val Val Val Ile Thr Asp
100 105 110
Ser Ala His Leu Asp Asp Val Arg Arg Thr Ala Pro Ala Val Thr Ile
115 120 125
Val Leu Val Gly Glu Glu Arg Ile Pro Pro Gly Val Arg Ser Phe Ala
130 135 140
Glu Leu Ala Thr Ala Glu Pro Gln Gln Ser Ala Arg Asp Asp Leu Gly
145 150 155 160
Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr
165 170 175
Pro Lys Gly Val Leu Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala
180 185 190
Tyr Cys Asp Ile Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu
195 200 205
Trp Pro Ala Pro Leu Phe His Ser Leu Ala Leu His Leu Cys Val Leu
210 215 220
Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Asn Gly Phe Val
225 230 235 240
Ala Ser Glu Val Leu Glu Glu Leu Thr Glu His Pro Cys Thr Val Leu
245 250 255
Val Gly Val Pro Thr Met Phe Arg Tyr Leu Leu Gly Ala Ala Asp Thr
260 265 270
Phe Glu Pro Arg Thr Ser Ser Leu Lys Met Gly Leu Val Ala Gly Ser
275 280 285
Val Ala Pro Ala Ser Leu Ile Glu Gly Phe Glu Asp Val Phe Gly Val
290 295 300
Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Ser Gly Ser Leu Thr
305 310 315 320
Val Asn Trp Leu Ser Gly Glu Arg Val Pro Gly Ser Cys Gly Leu Pro
325 330 335
Val Pro Gly Leu Ser Leu Arg Phe Val Asp Pro Ile Ser Gly Ala Asp
340 345 350
Val Ala Asp Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Ile
355 360 365
Met Ile Gly Tyr His Glu Gln Pro Glu Ala Thr Ala Glu Val Leu Ser
370 375 380
Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly
385 390 395 400
His Val Thr Ile Thr Gly Arg Ile Lys Glu Leu Ile Ile Arg Ser Gly
405 410 415
Glu Asn Ile His Pro His Glu Ile Glu Ala Val Ala Leu Asp Val Pro
420 425 430
Gly Val Lys Asp Ala Ala Ala Ala Gly Lys Arg His Pro Val Leu Gly
435 440 445
Glu Val Pro Val Leu Tyr Val Val Pro Glu Thr Gly Gly Val Asp Ala
450 455 460
Asp Met Val Leu Ala Val Cys Arg Glu Arg Leu Ser Tyr Phe Lys Val
465 470 475 480
Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Ala Ser Gly
485 490 495
Lys Val Lys Arg Ser Ser Leu Thr Glu Glu Pro Ala Glu Leu Leu Ala
500 505 510
Gly Ala Ser Gly Gly Glu Thr Leu His Arg Leu Glu Trp Ile Pro Leu
515 520 525
Glu Leu Pro Glu Gln Ala Ala Pro Asp Gly His Val Val Val Arg Val
530 535 540
Asp Ser Leu Ala Ser Asp Asp Ser Asp Leu Ala Asp Ala Asp Leu Ala
545 550 555 560
Asp Ala Val Arg Asp Leu Ala Arg Ser Trp Leu Ala Asp Lys Arg Arg
565 570 575
Ala Asp Ser Thr Leu Val Phe Val Thr Arg Arg Ala Val His Thr Gly
580 585 590
Pro Ser Asp Ile Pro Ser Pro Glu His Ala Ala Val Trp Asp Ala Ile
595 600 605
Arg Arg Glu Gln Thr Glu Asn Pro Gly Val Phe Val Val Ile Asp Val
610 615 620
Asp Asp Asp Asp Asp Asp Asp Asp Asp Val Asn Asp Arg Glu Asp Asp
625 630 635 640
Asp Thr Leu Leu Pro Ala Leu Ala Gly Leu Gly Glu Pro Gln Val Ala
645 650 655
Leu Arg Asp Gly Asn Pro Leu Val Pro Arg Leu Ala His Ala Asn Thr
660 665 670
Pro Asp Ser Gly Ser Leu Thr Ile Pro Glu Asp Arg Ala Trp Leu Leu
675 680 685
Glu His Ser Arg Ser Gly Thr Leu Arg Asp Leu Ala Leu Val Pro Ala
690 695 700
Asp Ala Ala Glu Arg Pro Leu His Pro Gly Glu Val Arg Ile Ser Val
705 710 715 720
Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu Gly Thr
725 730 735
Tyr Pro Gly Glu Gly Leu Met Gly Gly Glu Ala Ala Gly Val Val Leu
740 745 750
Glu Val Gly Ser Glu Val Ser Asp Leu Ala Pro Gly Asp Arg Val Phe
755 760 765
Gly Leu Val Gly Ser Ala Phe Gly Thr Val Ala Ile Ala Asp Arg Arg
770 775 780
Leu Leu Gly Ala Ile Pro Asp Thr Trp Ser Phe Ala Thr Ala Ala Ser
785 790 795 800
Ile Pro Ile Val Phe Ala Thr Ala Tyr Tyr Gly Leu Val Asp Leu Ala
805 810 815
Gly Leu Ser Ala Gly Glu Ser Val Leu Ile His Ala Ala Ala Gly Gly
820 825 830
Val Gly Met Ala Ala Thr Gln Ile Ala Arg His Leu Gly Ala Arg Ile
835 840 845
Phe Ala Thr Ala Ser Val Gly Lys Gln His Ile Leu Ser Glu Ala Gly
850 855 860
Leu Glu Asp Thr Arg Ile Ala Gly Ser Arg Thr Leu Ala Phe Arg Glu
865 870 875 880
Ala Phe Leu Asn Thr Thr Asp Gly Gln Gly Val Asp Val Val Leu Asn
885 890 895
Ser Leu Ser Gly Asp Phe Val Asp Ala Ser Leu Asp Leu Leu Pro Arg
900 905 910
Gly Gly Arg Phe Leu Glu Met Gly Lys Thr Asp Ile Arg Asp Ala Asp
915 920 925
Arg Ile Thr Ala Asp Arg Pro Gly Thr Thr Tyr Gln Ala Phe Asp Leu
930 935 940
Leu Asp Ala Gly Pro Asp Arg Leu Arg Glu Ile Ile Ala Glu Leu Leu
945 950 955 960
Pro Leu Phe Ala Gln Gly Val Leu Arg Pro Leu Pro Leu Leu Thr Trp
965 970 975
Asp Ile Arg Lys Ala Arg Asp Ala Phe Ser Trp Met Ser Arg Ala Arg
980 985 990
His Thr Gly Lys Ile Thr Phe Thr Ile Pro Arg Gln Leu Asp Pro Gly
995 1000 1005
Gly Thr Val Leu Ile Ala Asp Gly Ser Gly Val Leu Thr Gly Thr
1010 1015 1020
Val Ala Arg His Leu Val Ala Glu Gln Gly Val Arg His Leu Leu
1025 1030 1035
Leu Leu Ser Arg Ser Thr Pro Asp Glu Ala Leu Ile Asn Glu Leu
1040 1045 1050
Ile Glu Ser Gly Ala Arg Val Asp Thr Ala Val Arg Asp Val Ser
1055 1060 1065
Asp Arg Ala Gly Leu Glu Gln Ala Leu Ala Gly Ile Ser Pro Glu
1070 1075 1080
His Pro Leu Thr Ala Val Ile His Thr Gly Gly Pro Ala Val Ala
1085 1090 1095
His Glu Ser His Gln Leu His Gly Leu Thr Lys Arg Leu Asp Leu
1100 1105 1110
Ala Ala Phe Val Val Phe Ser Gln Asp Ala Pro Ala Ser Val Asp
1115 1120 1125
Ala Leu Ala Arg Arg Arg Arg Ala Glu Gly Leu Pro Thr Thr Thr
1130 1135 1140
Ile Ala Trp Gly Ile Pro Glu Ala Glu Ala Val Val Val Gln Gly
1145 1150 1155
Pro Leu Leu Gly Arg Ala Met Ala Ser Ala Asp Ser Ala His Ile
1160 1165 1170
Val Thr Arg Leu Asn Thr Val Gly Leu Arg Ala Leu Ala Ala Ala
1175 1180 1185
Asp Thr Leu Pro Pro Leu Leu Arg Asn Leu Val Gly Ala Gln Thr
1190 1195 1200
Asp Asn Thr Gln Gln Gln Ala Trp Ser Arg Gln Leu Leu Ala Ala
1205 1210 1215
Glu Ala Ala Arg Glu Gln Ala Leu Arg Asp Leu Val Arg Ser Cys
1220 1225 1230
Val Met Asp Ile Leu Gly Leu Ser Ala Ala Asp Arg Tyr Ala Pro
1235 1240 1245
Asp Lys Thr Phe Arg Glu Met Gly Ile Asp Ser Leu Thr Ala Val
1250 1255 1260
Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Asp Leu Arg Leu Pro
1265 1270 1275
Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Met Leu Val Val
1280 1285 1290
Arg Leu Gly Glu
1295
<210> 162
<211> 1217
<212> PRT
<213> Streptomyces violaceusniger
<400> 162
Met Ser Arg Glu Glu Phe Ile Gln Pro Ile His Asp Leu Leu Arg Val
1 5 10 15
Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg Arg
20 25 30
Glu Leu Thr His Ala Glu Leu Arg Thr Arg Thr Gly Arg Ile Ala Gly
35 40 45
His Leu Val Asp Leu Ala Val Glu Arg Gly Asp Arg Val Ala Ile Leu
50 55 60
Leu Gly Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg
65 70 75 80
Ala Gly Ala Ile Ala Val Pro Leu Asn Pro Asp Ala Thr Gly Ala Glu
85 90 95
Val Ala His Phe Leu Ala Asp Ser Gly Ala Val Leu Val Ile Thr Asp
100 105 110
Ser Ala His Leu Asp Asp Val Arg Arg Ala Ala Ala Ala Val Thr Val
115 120 125
Val Leu Val Asp Glu Gly Pro Leu Pro Ala Gly Thr Arg Ser Phe Ala
130 135 140
Glu Leu Ala Thr Ala Glu Pro Pro Thr Pro Ala Arg Asp Asp Leu Gly
145 150 155 160
Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr
165 170 175
Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala
180 185 190
Asn Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu
195 200 205
Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu
210 215 220
Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Ser Gly Phe Val
225 230 235 240
Ala Gly Glu Val Leu His Glu Leu Glu Glu His Ala Cys Thr Val Leu
245 250 255
Val Gly Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu
260 265 270
Ala Gly Pro Arg Leu Pro Ser Leu Lys Met Gly Leu Val Ala Gly Ala
275 280 285
Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Arg Val Phe Gly Val
290 295 300
Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr
305 310 315 320
Val Asn Arg Leu Ser Gly Pro Arg Met Pro Gly Ser Cys Gly Gln Ala
325 330 335
Val Pro Gly Ile Ser Leu Arg Phe Val Asp Pro His Thr Gly Ala Glu
340 345 350
Val Ala Glu Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Leu
355 360 365
Met Ile Gly Tyr His Gly Arg Pro Asp Ala Thr Arg Glu Val Leu Ser
370 375 380
Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly
385 390 395 400
His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Gly Gly
405 410 415
Glu Asn Ile His Pro Arg Asp Ile Glu Ala Val Ala Leu Glu Leu Pro
420 425 430
Gly Val Arg Asp Ala Ala Ala Ala Gly Lys Gln His Pro Val Leu Gly
435 440 445
Glu Ile Pro Ala Leu Tyr Leu Val Pro Asp Ala Asp Gly Val Asp Ala
450 455 460
Glu Ala Val Leu Ala Ala Cys Arg Glu Lys Leu Ser Tyr Phe Lys Val
465 470 475 480
Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Leu Ser Gly
485 490 495
Lys Val Lys Arg Ala Ala Leu Thr Glu Ala Pro Ala Glu Leu Leu Ser
500 505 510
Ala Ala Ser Gly Asn Gly Ser Leu Tyr Arg Leu Glu Trp Val Pro Ala
515 520 525
Glu Thr Pro Pro Ala Gly Thr Gly Gly Pro Val Ala Val His Val Thr
530 535 540
Arg Arg Ala Val Ala Thr Gly Pro Ala Asp Leu Pro Asp Gln Glu Gln
545 550 555 560
Ala Ala Thr Trp Asp Ala Leu Arg Gly Glu Gln Thr Gly Pro Gly Gly
565 570 575
Pro Val Leu Ile Asp Leu Asp Gly Ala Asp Ile Asp Asp Ala Arg Leu
580 585 590
Ser Ala Leu Ala Ser Leu Gly Glu Pro Gln Ile Val Val Arg Asp Asp
595 600 605
Thr Pro Leu Val Ala Arg Leu Ala Arg Glu Lys Ser Pro Ala Leu Thr
610 615 620
Ile Pro Gly Glu Arg Ala Trp Val Leu Glu Pro Asp His Ser Gly Val
625 630 635 640
Leu Gln Glu Leu Ala Leu Val Ala Ala Asp Thr Asp Val Arg Pro Leu
645 650 655
Arg Pro Gly Glu Val Arg Ile Glu Val Arg Ala Ala Gly Leu Asn Phe
660 665 670
Arg Asp Val Leu Val Ala Leu Gly Thr Asp Leu Gly Asp Gly Val Phe
675 680 685
Gly Ala Glu Gly Ala Gly Val Val Leu Glu Thr Gly Ser Asp Val Arg
690 695 700
Asp Leu Arg Pro Gly Asp Arg Val Phe Gly Leu Leu Glu Gly Gly His
705 710 715 720
Gly Ser Ile Ala Ile Ala Asp Arg Arg Met Leu Ala Val Ile Pro Glu
725 730 735
Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Glu Val Phe Val Ile
740 745 750
Ala Tyr Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser
755 760 765
Val Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala Thr Gln
770 775 780
Ile Ala Arg His Leu Gly Ala Gln Val Tyr Ala Thr Ala Gly Val Gly
785 790 795 800
Lys Gln His Ile Leu Arg Asp Ala Gly Leu Gly Asp Asp Arg Ile Ala
805 810 815
Asp Ser Arg Thr Thr Asp Phe Arg Glu Ala Phe Arg Asp Ser Thr Gln
820 825 830
Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Lys Gly Asp Phe Val
835 840 845
Asp Ala Ser Leu Asp Leu Leu Ala Asp Gly Gly Arg Phe Leu Glu Leu
850 855 860
Gly Gln Thr Asp Ile Arg Asp Ala Gly Glu Ile Ala Ala Glu Arg Pro
865 870 875 880
Gly Thr Thr Tyr His Ser Phe Thr Arg Met Asn Ala Gly Pro Asp Arg
885 890 895
Leu Arg Glu Ile Ile Ala Glu Leu Leu Ala Leu Phe Glu Gln Gly Val
900 905 910
Leu Arg Pro Ser Pro Val His Thr Trp Asp Ile Arg His Ala Arg Glu
915 920 925
Ala Phe Ser Trp Met Ser Gly Gly Arg His Thr Gly Lys Met Val Leu
930 935 940
Thr Met Pro Gln Arg Ile Asp Pro Gly Gly Thr Val Leu Ile Ala Gly
945 950 955 960
Asp Ser Glu Ala Leu Ala Arg Ile Ala Ala Arg His Leu Gly Val Arg
965 970 975
His Leu Leu Leu Asp Arg Gly Val Ala Asp Ala Ala Pro Asp Ala Val
980 985 990
Val Cys Asp Val Ser Asp His Asp Ala Leu Glu Arg Val Leu Ala Asp
995 1000 1005
Leu Ser Pro Glu His Pro Leu Thr Ala Val Ile His Thr Gly Gly
1010 1015 1020
Ala Ala Val Thr Asp Glu Ile Arg Arg Leu His Asp Leu Thr Glu
1025 1030 1035
Ser Leu Asp Leu Thr Asp Phe Val Val Phe Ser Gln Asp Ala Pro
1040 1045 1050
Ala Ala Val Glu Ala Phe Ala Arg Ser Arg Arg Ala His Gly Leu
1055 1060 1065
Pro Val Arg Thr Ile Ala Trp Gly Ile Pro Glu Ala Asp Pro Val
1070 1075 1080
Val Ala Asp Glu His Leu Leu Gly Arg Ala Leu Ala Ser Ala Glu
1085 1090 1095
Gln Ala Gln Ile Val Ala Arg Val Asn Thr Ala Gly Leu Arg Ala
1100 1105 1110
Leu Thr Ala Ala Asn Ala Leu Pro Thr Leu Leu Arg Asn Leu Ile
1115 1120 1125
Arg Ala Glu Pro Glu Glu Thr Gly Gln Ser Ala Trp Pro His Arg
1130 1135 1140
Phe Glu Ala Ala Gly Ala Asp Arg Glu Glu Ala Leu Leu Asp Leu
1145 1150 1155
Ile Arg Ala Asn Val Val Asp Ile Leu Ser Leu Pro Thr Ala Asp
1160 1165 1170
Arg Tyr Ala Pro Asp Arg Thr Phe Arg Glu Met Gly Ile Asp Ser
1175 1180 1185
Leu Thr Ala Val Gly Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly
1190 1195 1200
Leu Pro Leu Pro Thr Thr Met Val Phe Asp Tyr Pro Thr Pro
1205 1210 1215
<210> 163
<211> 1299
<212> PRT
<213> Streptomyces filamentosus
<400> 163
Met Ser His Ala Lys Leu Ile Gln Pro Ile Tyr Asp Leu Leu Arg Val
1 5 10 15
Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg His
20 25 30
Ala Leu Thr Tyr Thr Glu Leu Glu Ala Arg Thr Gly Arg Leu Ala Gly
35 40 45
His Leu Ala Asp Leu Gly Val Glu Arg Gly Asp Arg Val Ala Ile Leu
50 55 60
Leu Asp Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg
65 70 75 80
Ala Ser Ala Ile Ala Val Pro Leu Asn Pro Ala Ala Ala Gly Asp Glu
85 90 95
Leu Ala His Phe Leu Ser Asp Ser Gly Ser Val Leu Val Ile Thr Asp
100 105 110
Ser Ala His Leu Asp Asp Val Arg Leu Val Ala Pro Ala Val Thr Val
115 120 125
Val Arg Val Asp Glu Asp Pro Val Pro Pro Gly Val Arg Ser Phe Ala
130 135 140
Glu Leu Val Ala Val Glu Pro Arg Thr Gln Ala Arg Asp Asp Leu Gly
145 150 155 160
Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr
165 170 175
Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala
180 185 190
Phe Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Glu Asp Val Leu Leu
195 200 205
Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu
210 215 220
Ala Thr Ile Thr Ala Gly Ala Thr Ala Arg Ile Met Asn Gly Phe Val
225 230 235 240
Ala Ser Glu Val Leu Asn Glu Leu Glu Lys His Ala Cys Thr Val Leu
245 250 255
Val Cys Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu
260 265 270
Gly Glu Ser Arg Thr Phe Ser Leu Lys Leu Gly Val Val Ala Gly Ser
275 280 285
Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Lys Ala Phe Gly Ala
290 295 300
Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr
305 310 315 320
Val Asn Trp Leu Asn Gly Pro Arg Val Pro Gly Ser Cys Gly Thr Ala
325 330 335
Val Pro Gly Val Thr Leu Arg Phe Val Asp Pro Ser Thr Gly Ala Asp
340 345 350
Val Ala Asp Gly Glu Glu Gly Glu Leu Trp Ala Ser Ala Pro Ser Val
355 360 365
Met Thr Gly Tyr His Gly Gln Pro Glu Ala Thr Arg Glu Val Leu Thr
370 375 380
Asp Gly Trp Tyr His Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly
385 390 395 400
His Val Thr Ile Thr Gly Arg Ile Lys Glu Leu Ile Ile Arg Gly Gly
405 410 415
Glu Asn Ile His Pro Gln Glu Ile Glu Ala Ala Val Leu Gly Leu Pro
420 425 430
Gly Val Arg Asp Ala Ala Ala Ala Gly Arg Pro His Pro Val Leu Gly
435 440 445
Asp Val Pro Ala Leu Tyr Ile Val Pro Asp Ala Asp Gly Val Asp Ala
450 455 460
Asp Ala Val Leu Ala Ala Cys Arg Glu Arg Leu Ser Tyr Phe Lys Val
465 470 475 480
Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Met Ser Gly
485 490 495
Lys Val Lys Arg Thr Ser Leu Thr Glu Ala Pro Ala Glu Leu Leu Ala
500 505 510
Gly Ala Ser Gly Ser Asp Ala Leu Tyr Arg Leu Lys Trp Val Pro Ala
515 520 525
Glu Thr Pro Gly Pro Ala Ala Thr Gly Gly His Val Ile Val Arg Val
530 535 540
Ala Ser Leu Arg Ala Asp Gly Thr Glu Leu Ala Gly Ala Ala Arg Asp
545 550 555 560
Leu Ala Arg Ser Trp Leu Ser Asp Glu Arg Arg Ala Gly Ala Thr Leu
565 570 575
Val Phe Val Thr Gly Arg Ala Val Ser Ala Gly Pro Ser Asp Val Pro
580 585 590
Val Pro Glu His Ala Ala Val Trp Asp Ala Ile Arg Asp Glu Gln Thr
595 600 605
Glu Asn Pro Gly Ala Phe Val Leu Ile Asp Leu Glu Glu Ala Glu Thr
610 615 620
Glu Glu Pro Glu Ser Ala Ala Pro Glu Ala Gly Asp Pro Gln Ala Asp
625 630 635 640
Thr Pro Gly Ala Asp Asp Thr Arg Leu Ser Thr Leu Val Ala Leu Gly
645 650 655
Glu Pro Gln Ile Ala Leu Arg Asp Ser Thr Pro Leu Val Pro Arg Leu
660 665 670
Ala Pro Glu Ser Ser Thr Ala Leu Thr Thr Pro Ala Ala Arg Ala Trp
675 680 685
Val Leu Glu Pro Ala Arg Ser Gly Thr Leu Arg Glu Leu Ser Leu Val
690 695 700
Ala Ala Asp Thr Asp Ala Arg Pro Leu Arg Pro Gly Glu Val Arg Val
705 710 715 720
Asp Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Leu Ile Ala Leu
725 730 735
Gly Thr Tyr Pro Gly Asp Gly Val Met Gly Gly Glu Ala Ala Gly Val
740 745 750
Val Leu Glu Val Gly Pro Glu Val Asn Asp Leu Ser Val Gly Asp Arg
755 760 765
Val Phe Gly Leu Val Thr Asp Gly Phe Gly Pro Val Thr Ile Thr Asp
770 775 780
Arg Arg Leu Leu Ala Ala Met Pro Gln Asp Trp Ser Phe Thr Thr Ala
785 790 795 800
Ala Ser Ala Ala Met Ala Phe Ala Thr Ala His Tyr Gly Leu Val Glu
805 810 815
Leu Ala Gly Leu Lys Ala Gly Glu Ser Val Leu Ile His Ala Ala Thr
820 825 830
Gly Gly Val Gly Met Ala Ala Thr Gln Ile Ala His His Leu Gly Ala
835 840 845
His Ile Tyr Ala Thr Ala Ser Ser Gly Lys Gln His Leu Leu Arg Ala
850 855 860
Ala Gly Ile Asp Asp Asp Arg Ile Ala Asn Ser Arg Thr Thr Gly Phe
865 870 875 880
Arg Asp Ala Phe Leu Asp Ser Thr Gly Gly Arg Gly Val Asp Val Val
885 890 895
Leu Asn Ser Leu Ser Gly Glu Phe Val Asp Ser Ser Leu Asp Leu Leu
900 905 910
Ala His Gly Gly Arg Phe Ile Glu Met Ser Thr Asp Ile Arg Asp Ala
915 920 925
Gly Arg Ile Ala Ala Glu Arg Pro Gly Thr Thr Tyr Gln Ala Phe His
930 935 940
Leu Val Asp Ala Asp Pro Asp Arg Leu Arg Glu Ile Leu Thr Glu Leu
945 950 955 960
Leu Ala Leu Phe Asp Gln Gly Ile Leu Asp Pro Leu Pro Val Gln Ala
965 970 975
Trp Asp Ile Arg Gln Ala Arg Glu Ala Phe Ser Trp Met Ser Arg Ala
980 985 990
Arg His Thr Gly Lys Leu Val Leu Thr Ile Pro Gln His Ile Asp Pro
995 1000 1005
Asp Gly Thr Val Leu Ile Thr Gly Gly Ser Gly Gly Leu Ala Gly
1010 1015 1020
Val Val Ala Arg His Leu Val Ala Asp Lys Gly Ala Arg Arg Leu
1025 1030 1035
Leu Leu Leu Ser Cys Asp Thr Leu Asp Ala Thr Leu Ala Ala Glu
1040 1045 1050
Leu Thr Glu Ser Gly Ala Arg Val Asp Thr Ala Val Cys Asp Val
1055 1060 1065
Ser Asp Arg Ala Ala Leu Ala Gln Val Leu Ala Gly Val Ser Pro
1070 1075 1080
Glu His Pro Leu Thr Ala Ile Val His Ala Gly Gly Ala Ala Val
1085 1090 1095
Ala Asp Glu Ser Arg Gln Leu His His Leu Thr Lys Asn Arg Asp
1100 1105 1110
Leu Ala Ala Phe Val Val Phe Ser Gln Asp Ala Pro Ala Ala Thr
1115 1120 1125
Glu Ala Phe Ala Gly Ile Arg Gln Ala Glu Gly Leu Pro Val Thr
1130 1135 1140
Thr Ile Ala Trp Gly Ile Pro Glu Ala Glu Pro Val Val Val Gly
1145 1150 1155
Gln His Leu Leu Asp Arg Ala Met Ala Ser Ala Asp Arg Ala His
1160 1165 1170
Val Ala Ala Arg Val Asn Thr Ala Gly Leu Arg Ala Leu Ala Ala
1175 1180 1185
Ala Asn Ala Leu Pro Pro Val Leu Lys Asn Leu Val Gly Ala Glu
1190 1195 1200
Thr Asp Gly Thr Gly His Gln Asp Trp Ser Arg Arg Phe Met Val
1205 1210 1215
Ala Glu Ala Ala Arg Gln Gln Glu Leu Leu Asp Leu Ile Arg Thr
1220 1225 1230
Thr Val Met Glu Ile Leu Ser Leu Pro Thr Thr Ala Arg Tyr Phe
1235 1240 1245
Pro Asp Arg Thr Phe Arg Glu Asn Gly Ile Asp Ser Leu Thr Ala
1250 1255 1260
Val Glu Leu Val Asn Ser Leu Ala Lys Thr Thr Gly Leu Arg Leu
1265 1270 1275
Ser Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Thr Ala Leu Ala
1280 1285 1290
Gly Arg Met Arg Glu Leu
1295
<210> 164
<211> 1239
<212> PRT
<213> Streptomyces hygroscopicus
<400> 164
Met Ser Arg Leu Asp Leu Ile Arg Pro Leu Ser Glu Ser Leu Cys Ala
1 5 10 15
Ser Ala Ala Ser Phe Gly Asp Lys Val Ala Tyr Thr Asp Ser Arg Arg
20 25 30
Ser Val Thr Tyr Ala Glu Leu Gln Ile Arg Thr Gly Arg Leu Ala Gly
35 40 45
His Leu Ala Glu His Gly Val Ala Arg Gly Asp Arg Val Ala Ile Leu
50 55 60
Leu Gly Asn Arg Val Glu Ile Ile Glu Ser Tyr Leu Ala Val Ala Arg
65 70 75 80
Ala Ser Ala Val Ala Val Pro Leu Asn Pro Asp Ala Met Asp Ala Glu
85 90 95
Leu Ala His Phe Leu Arg Asp Ser Gly Ala Val Val Val Ile Thr Asp
100 105 110
Leu Ala His Leu Glu Gln Thr Arg Gly Val Ala Pro Ala Met Thr Val
115 120 125
Val Leu Ile Gly Asp Gly Arg Thr Val Pro Gly Thr Ser Ser Phe Ala
130 135 140
Glu Leu Ala Asp Thr Glu Pro Ala Ser Pro Ala Arg Asp Asp Leu Arg
145 150 155 160
Leu Asp Glu Pro Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr
165 170 175
Pro Lys Gly Val Val Ser Ala Gln Arg Ser Gly Leu Trp Ser Ala Ala
180 185 190
Ser Cys Asp Val Pro Ala Trp Asp Leu Ser Asp Glu Asp Leu Leu Leu
195 200 205
Trp Pro Ala Pro Leu Phe His Ser Leu Gly His His Leu Cys Leu Leu
210 215 220
Ala Val Val Ala Val Gly Ala Ser Ala Arg Ile Met Ser Gly Phe Ala
225 230 235 240
Ala Asp Glu Val Leu Asp Ala Leu Arg Glu His Pro Cys Thr Val Leu
245 250 255
Val Gly Val Pro Thr Met Tyr Arg Tyr Leu Leu Ala Ala Val Gly Glu
260 265 270
Ser Gly Ala Asp Ala Pro Ala Leu Lys Met Ala Leu Ile Ala Gly Ser
275 280 285
Val Thr Pro Ala Ser Leu Val Glu Ala Phe Glu Arg Ser Phe Gly Val
290 295 300
Pro Leu Ile Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Val Thr
305 310 315 320
Ala Asn Arg Leu His Gly Glu Arg Val Pro Gly Ser Cys Gly Val Pro
325 330 335
Val Pro Gly Val Glu Ile Arg Leu Val Asp Pro Val Thr Gly Ala Asp
340 345 350
Val Pro Leu Gly Ala Glu Gly Glu Leu Trp Ala Lys Thr Pro Ser Val
355 360 365
Met Ile Gly Tyr His Gly Gln Pro Glu Ala Thr Gly Glu Val Leu Val
370 375 380
Asp Gly Trp Tyr Arg Ser Gly Asp Leu Ala Arg Arg Gln Glu Ser Gly
385 390 395 400
His Ile Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Ser Gly
405 410 415
Glu Asn Ile His Pro Arg Glu Ile Glu Thr Val Ala Leu Glu Val Pro
420 425 430
Gly Val Glu Asp Ala Ala Ala Ala Gly Lys Pro His Arg Val Leu Gly
435 440 445
Glu Val Pro Val Leu Tyr Val Val Pro Ala Glu Ala Gly Val Asp Val
450 455 460
Thr Ala Val Phe Ala Ala Cys Arg Glu Gln Leu Ser Tyr Phe Lys Val
465 470 475 480
Pro Glu Glu Ile Tyr Gln Val Glu Ser Ile Pro Arg Thr Pro Ser Gly
485 490 495
Lys Val Lys Arg Gly Leu Leu Thr Glu Gln Pro Ala Glu Leu Leu Ala
500 505 510
Ala Ala Asp Gly Gly Gly Ser Leu Tyr Arg Val Glu Trp Arg Pro Ala
515 520 525
Val Pro Pro Gly Ala Gly Asp Thr Gly Gly Asp Ser Pro Val Val Val
530 535 540
Arg Val Asp Ser Leu Pro Ala Asp Glu Gln Glu Leu Leu Gly Ala Val
545 550 555 560
Arg Asp Leu Ile His Asp Arg Ile Ala Asp Pro Arg Arg Thr Thr Ala
565 570 575
Pro Leu Val Phe Val Thr Arg His Ala Val Leu Ser Arg Asn Pro Ala
580 585 590
His Ala His Ala Ala Val Trp Asp Leu Val Ser Arg Ala Gln Ala Asp
595 600 605
Asn Pro Gly Leu Phe Val Leu Val Asp Ala Asp Gly Asp Asp Ala Pro
610 615 620
Leu Pro Ser Ala Val Gly Leu Gly Glu Pro Arg Val Ala Trp Arg Asp
625 630 635 640
Gly Gly Leu Leu Val Pro Arg Leu Ala His Pro Gly Thr Glu Ala Leu
645 650 655
Ile Ala Pro Glu Ser Gly Ser Trp Leu Leu Ala Glu Thr Gly Gly Gly
660 665 670
Thr Leu Arg Asp Leu Ala Leu Val Gly Thr Asp Thr Ala Asp Arg Val
675 680 685
Leu Leu Pro Gly Glu Val Arg Ile Ala Val Arg Ala Ala Gly Leu Asn
690 695 700
Phe Arg Asp Val Thr Val Ala Leu Gly Val Val Ser Asp Asp Arg Leu
705 710 715 720
Met Gly Gly Glu Ala Ala Gly Val Val Leu Asp Val Ala Pro Asp Val
725 730 735
Thr Asp Leu Glu Pro Gly Asp Arg Val Phe Gly Leu Val Glu Gly Ala
740 745 750
Phe Ala Ser Val Ala Val Thr Asp Arg Arg Leu Leu Gly Arg Ile Pro
755 760 765
Ala Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Val Val Phe Ser
770 775 780
Thr Ala Tyr His Ala Leu Thr Asp Leu Val Asp Leu Arg Pro Gly Glu
785 790 795 800
Ala Ile Leu Ile His Ala Ala Ala Gly Gly Val Gly Met Ala Ala Thr
805 810 815
Gln Leu Ala Arg His Ile Gly Ala Lys Ile Tyr Ala Thr Ala Ser Pro
820 825 830
Ala Lys Gln His Ala Leu Leu Gly Val Asp Gln Val Ala Asn Ser Arg
835 840 845
Thr Thr Glu Phe Arg Gly Thr Phe Leu Glu Ala Thr Gly Gly Arg Gly
850 855 860
Val Asp Val Val Leu Asn Ser Leu Ala Gly Glu His Ile Asp Ala Ser
865 870 875 880
Leu Glu Leu Leu Pro Arg Gly Gly Arg Phe Leu Glu Leu Gly Lys Thr
885 890 895
Asp Leu Arg Asp Pro Arg His Leu Pro Ala Gly Val Ser Tyr Gln Val
900 905 910
Leu Asn Arg Leu Asp Ser Ser Pro Asp Arg Val Arg Glu Ile Leu Ala
915 920 925
Glu Leu Leu Val Met Phe Glu Arg Gly Val Leu Arg Pro Leu Pro Val
930 935 940
Arg Thr Trp Asp Ile Arg Glu Ala Pro Glu Ala Phe Ser Trp Met Ser
945 950 955 960
Arg Gly Arg His Leu Gly Lys Ile Val Leu Thr Ile Pro Arg Asp Leu
965 970 975
Asp Pro Asp Gly Thr Val Leu Val Thr Gly Ala Ser Ala Asp His Met
980 985 990
Ala Arg Tyr Leu Ser Ala Glu Arg Gly His Ala His Val Leu Val Ser
995 1000 1005
Asp Asp Pro Ala Ala Val Pro Ala Thr His Pro Leu Thr Ala Val
1010 1015 1020
Val His Thr Gly Gly Asp Glu Val Val Ser Glu Ser Thr Arg Leu
1025 1030 1035
His Gln Leu Thr Arg Glu Leu Asp Leu Ala Ala Phe Ala Val Phe
1040 1045 1050
Ser Gln Ser Ala Pro Ala Ser Val Glu Ala Leu Val Arg His Arg
1055 1060 1065
Arg Thr Glu Gly Leu Pro Ala Thr Ala Val Ser Trp Gly Leu Pro
1070 1075 1080
Glu Ala Glu Pro Ala Pro Val Gln Gly Ala Leu Leu Asp Arg Thr
1085 1090 1095
Ile Ala Ser Val Glu Pro Ala His Val Val Thr Arg Val Asn Ser
1100 1105 1110
Ala Gly Leu Arg Ala Leu Ala Asn Ser Gly Glu Leu Pro Ser Val
1115 1120 1125
Leu Arg Asp Val Thr Pro Ala Leu Ser Ala Lys Trp Pro Arg Pro
1130 1135 1140
Gly Thr Pro Arg Pro Gly Thr Pro Arg Pro Gly Thr Pro His Pro
1145 1150 1155
Ala Ala Leu Asp Gln Ala Ala Leu Leu Asp Leu Val Arg Glu Ser
1160 1165 1170
Leu Thr Thr Val Leu Gly Leu Pro Gly Val Glu Ser Cys Ala Pro
1175 1180 1185
Asp Arg Pro Phe Arg Glu Thr Gly Leu Asp Ser Leu Thr Thr Ile
1190 1195 1200
Gly Leu Ala Asn Thr Leu Ser Ala Arg Leu Gly Arg Lys Leu Pro
1205 1210 1215
Ala Thr Met Ile Phe Asp His Pro Thr Pro Arg Thr Leu Ala Thr
1220 1225 1230
Arg Leu Ala Glu Glu Leu
1235
<210> 165
<211> 878
<212> PRT
<213> Micromonospora sp.
<400> 165
Met Thr Pro Ala Tyr Asp Val Arg Pro Leu Pro Glu Leu Leu Ile Ala
1 5 10 15
Asn Ala Glu Arg Leu Gly Asp Lys Pro Ala Tyr Thr Gly Leu His Arg
20 25 30
Thr Val Gly His Ala Glu Leu Ala Asp Arg Thr Arg Arg Ala Ala Gly
35 40 45
His Leu Ala Gly Phe Ala Ala Arg Gly Asp Arg Ile Ala Leu Leu Leu
50 55 60
Gly Asn Arg Val Glu Met Val Glu Gly Tyr Leu Ala Val Ala Arg Ala
65 70 75 80
Ala Ala Val Ala Val Pro Leu Asn Pro Gln Ala Ser Asp Ala Glu Leu
85 90 95
Ala His Phe Leu Thr Asp Ser Glu Ala Val Ala Val Leu Ala Asp Ala
100 105 110
Glu His Thr Glu Gln Val Arg Arg Val Ala Pro Gly Leu Arg Leu Val
115 120 125
Pro Ile Gly Glu Trp Glu Thr Leu Ala Thr Thr Glu Pro Asp Arg Pro
130 135 140
Ala Arg Asp Asp Leu Gly Leu Asp Glu Val Ala Trp Met Leu Tyr Thr
145 150 155 160
Ser Gly Thr Thr Gly Ala Pro Lys Gly Val Leu Ser Thr Gln Gly Ser
165 170 175
Gly Leu Trp Ser Ala Tyr His Cys Asp Val Pro Ala Leu Gly Leu Thr
180 185 190
Asp Ala Asp Val Leu Leu Trp Pro Ala Pro Leu Phe His Ser Leu Ala
195 200 205
His His Leu Ala Val Leu Ala Ala Thr Val Ser Gly Ala Thr Val Arg
210 215 220
Leu Leu Ser Gly Phe Ala Ala Asp Glu Val Leu Arg Glu Leu Arg Glu
225 230 235 240
Glu Gly Cys Thr Leu Leu Ala Gly Val Pro Thr Met Tyr His Tyr Leu
245 250 255
Leu Gly Ala Ala Gly Pro Asp Asp Glu Val Arg Ala Pro Ala Leu Arg
260 265 270
Gly Ala Val Val Ala Gly Ala Val Thr Pro Ala Ala Leu Ile Thr Ala
275 280 285
Phe Gly Glu Arg Phe Gly Ala Pro Leu Leu Asp Thr Tyr Gly Cys Thr
290 295 300
Glu Thr Thr Gly Ser Leu Thr Ile Asn Arg Leu Asp Gly Pro Arg Val
305 310 315 320
Pro Gly Ser Cys Gly Val Ala Val Pro Gly Val Arg Leu Arg Leu Val
325 330 335
Asp Pro Arg Thr Gly Asp Asp Ala Pro Glu Gly Gly Glu Gly Glu Ile
340 345 350
Trp Ala Ser Gly Pro Ser Leu Met Arg Gly Tyr His Arg Arg Pro Asp
355 360 365
Ala Thr Ala Glu Val Leu Ala Asp Gly Trp Tyr Arg Thr Gly Asp Leu
370 375 380
Ala Val Arg Ala Ala Thr Gly His Ile Thr Ile Thr Gly Arg Val Lys
385 390 395 400
Glu Leu Ile Ile Arg Gly Gly Glu Asn Ile His Pro Arg Glu Ile Glu
405 410 415
Ala Val Leu Ala Glu Val Pro Gly Val Ala Asp Val Ala Val Ala Gly
420 425 430
Arg Ser His Ala Val Leu Gly Asp Leu Pro Val Ala Tyr Leu Val Thr
435 440 445
Glu Ala Gly Leu Asp Pro Ala Ala Leu Phe Ala Ala Cys Arg Glu Arg
450 455 460
Leu Ser Ser Phe Lys Val Pro Glu Glu Val Tyr Arg Val Ala Ala Val
465 470 475 480
Pro Arg Thr Pro Ser Gly Lys Ile Lys Arg Arg Glu Leu Val Ala Gly
485 490 495
Pro Ala Glu Leu Leu Ala Thr Ala Gly Gly Ala Glu Thr Leu Leu Arg
500 505 510
Thr Arg Trp Thr Ala Val Asp Val Leu Asp Pro Ala Ser Leu Asp Gly
515 520 525
Trp Arg Val Val His Ala Asp Gln Glu Val Asp Leu Gly Gly Arg Leu
530 535 540
Asp Asp Asp Gly Pro Ala Ile Val Val Thr Thr Arg Ala Val Arg Thr
545 550 555 560
Ser Ala Asp Glu Arg Pro Ser Ala Ser Ala Ala Ala Ala Trp Asp Leu
565 570 575
Val Thr Ala Ala Gln Ala Arg Arg Pro Gly Arg Tyr Leu Leu Val Asp
580 585 590
Thr Asp Gly Val Pro Gly Gly Leu Gly Ala Ala Leu Ala Thr Gly Glu
595 600 605
Pro Gln Val Ala Val Arg Glu Asp Val Val Leu Val Pro Arg Leu Glu
610 615 620
Ala Ala Gly Glu Thr Gly Ala Pro Val Arg Leu Asp Gly Thr Val Leu
625 630 635 640
Val Thr Gly Glu His Thr Glu Arg Val Ala Arg His Leu Arg Ala Arg
645 650 655
Gly Val Thr Val Thr Asp Asp Pro Ala Ala Arg Pro Leu His Ala Val
660 665 670
Val His Val Gly Gly Thr Ser Gly Leu Ala Glu Leu Ala Glu Leu Thr
675 680 685
Gly Cys Pro Glu Arg Ala Ala Phe Val Val Cys Thr Glu Asp Ser Arg
690 695 700
Ala Thr Ala Asp Ala Leu Val Arg Ala Ile Pro Gly Gly Val Ala Val
705 710 715 720
Gly Val Gly Leu Pro Gly Ile Glu Pro Ala Ala Leu Leu Pro Glu Leu
725 730 735
Leu Asp Arg Leu Thr Ala Asp Gly Pro Tyr Val Val Ala Arg Pro Gly
740 745 750
Ser Thr Gly Leu Arg Ala Leu Ala Thr Ala Gly Arg Leu Pro Ala Gly
755 760 765
Leu Gly Ala Leu Val Asp Thr Gly Ala Ala Pro Asp Pro Asp Ala Ala
770 775 780
Val Arg Arg Asp Leu Val Arg Arg Leu Ile Ala Leu Pro Arg Arg Ala
785 790 795 800
Arg Asp Gln Ala Leu Val Glu Leu Val Trp Asp Ala Val Arg Ala Thr
805 810 815
Leu Gly Ala Gly Ala Thr Pro Gly Gly Pro Gly Gln Ala Phe Ser Glu
820 825 830
Val Gly Phe Asp Ser Leu Thr Ser Val Gln Leu Arg Asn Arg Leu Val
835 840 845
Ala Ala Thr Gly Val Arg Leu Ser Ala Thr Ala Val Phe Asp Phe Pro
850 855 860
Thr Pro Arg Ala Leu Ala Asp Glu Leu Gly Arg Val Leu Ile
865 870 875
<210> 166
<211> 7934
<212> PRT
<213> Streptomyces violaceusniger
<400> 166
Met Ser Arg Glu Glu Phe Ile Gln Pro Ile His Asp Leu Leu Arg Val
1 5 10 15
Asn Ala Glu Arg Leu Gly Asp Lys Ile Ala Tyr Ala Asp Ser Arg Arg
20 25 30
Glu Leu Thr His Ala Glu Leu Arg Thr Arg Thr Gly Arg Ile Ala Gly
35 40 45
His Leu Val Asp Leu Ala Val Glu Arg Gly Asp Arg Val Ala Ile Leu
50 55 60
Leu Gly Asn Arg Val Glu Thr Ile Glu Ser Tyr Leu Ala Ile Ala Arg
65 70 75 80
Ala Gly Ala Ile Ala Val Pro Leu Asn Pro Asp Ala Thr Gly Ala Glu
85 90 95
Val Ala His Phe Leu Ala Asp Ser Gly Ala Val Leu Val Ile Thr Asp
100 105 110
Ser Ala His Leu Asp Asp Val Arg Arg Ala Ala Ala Ala Val Thr Val
115 120 125
Val Leu Val Asp Glu Gly Pro Leu Pro Ala Gly Thr Arg Ser Phe Ala
130 135 140
Glu Leu Ala Thr Ala Glu Pro Pro Thr Pro Ala Arg Asp Asp Leu Gly
145 150 155 160
Leu Asp Glu Ala Ala Trp Met Leu Tyr Thr Ser Gly Thr Thr Gly Thr
165 170 175
Pro Lys Gly Val Val Ser Thr Gln Gly Ser Gly Leu Trp Ser Ala Ala
180 185 190
Asn Cys Asp Val Pro Ala Trp Glu Leu Thr Glu Asn Asp Val Leu Leu
195 200 205
Trp Pro Ala Pro Leu Phe His Ser Leu Ala His His Leu Cys Leu Leu
210 215 220
Ala Thr Thr Ala Val Gly Ala Thr Ala Arg Ile Met Ser Gly Phe Val
225 230 235 240
Ala Gly Glu Val Leu His Glu Leu Glu Glu His Ala Cys Thr Val Leu
245 250 255
Val Gly Val Pro Thr Met Tyr His Tyr Leu Leu Gly Ala Val Gly Glu
260 265 270
Ala Gly Pro Arg Leu Pro Ser Leu Lys Met Gly Leu Val Ala Gly Ala
275 280 285
Val Ser Pro Pro Ala Leu Ile Glu Gly Phe Glu Arg Val Phe Gly Val
290 295 300
Pro Leu Leu Asp Thr Tyr Gly Cys Thr Glu Thr Thr Gly Ser Leu Thr
305 310 315 320
Val Asn Arg Leu Ser Gly Pro Arg Met Pro Gly Ser Cys Gly Gln Ala
325 330 335
Val Pro Gly Ile Ser Leu Arg Phe Val Asp Pro His Thr Gly Ala Glu
340 345 350
Val Ala Glu Gly Glu Glu Gly Glu Leu Trp Ala Ser Gly Pro Ser Leu
355 360 365
Met Ile Gly Tyr His Gly Arg Pro Asp Ala Thr Arg Glu Val Leu Ser
370 375 380
Asp Gly Trp Tyr Arg Thr Gly Asp Leu Ala Arg Arg Ser Glu Thr Gly
385 390 395 400
His Val Thr Ile Thr Gly Arg Val Lys Glu Leu Ile Ile Arg Gly Gly
405 410 415
Glu Asn Ile His Pro Arg Asp Ile Glu Ala Val Ala Leu Glu Leu Pro
420 425 430
Gly Val Arg Asp Ala Ala Ala Ala Gly Lys Gln His Pro Val Leu Gly
435 440 445
Glu Ile Pro Ala Leu Tyr Leu Val Pro Asp Ala Asp Gly Val Asp Ala
450 455 460
Glu Ala Val Leu Ala Ala Cys Arg Glu Lys Leu Ser Tyr Phe Lys Val
465 470 475 480
Pro Glu Glu Ile Tyr Arg Val Asp Ala Ile Pro Arg Thr Leu Ser Gly
485 490 495
Lys Val Lys Arg Ala Ala Leu Thr Glu Ala Pro Ala Glu Leu Leu Ser
500 505 510
Ala Ala Ser Gly Asn Gly Ser Leu Tyr Arg Leu Glu Trp Val Pro Ala
515 520 525
Glu Thr Pro Pro Ala Gly Thr Gly Gly Pro Val Ala Val His Val Thr
530 535 540
Arg Arg Ala Val Ala Thr Gly Pro Ala Asp Leu Pro Asp Gln Glu Gln
545 550 555 560
Ala Ala Thr Trp Asp Ala Leu Arg Gly Glu Gln Thr Gly Pro Gly Gly
565 570 575
Pro Val Leu Ile Asp Leu Asp Gly Ala Asp Ile Asp Asp Ala Arg Leu
580 585 590
Ser Ala Leu Ala Ser Leu Gly Glu Pro Gln Ile Val Val Arg Asp Asp
595 600 605
Thr Pro Leu Val Ala Arg Leu Ala Arg Glu Lys Ser Pro Ala Leu Thr
610 615 620
Ile Pro Gly Glu Arg Ala Trp Val Leu Glu Pro Asp His Ser Gly Val
625 630 635 640
Leu Gln Glu Leu Ala Leu Val Ala Ala Asp Thr Asp Val Arg Pro Leu
645 650 655
Arg Pro Gly Glu Val Arg Ile Glu Val Arg Ala Ala Gly Leu Asn Phe
660 665 670
Arg Asp Val Leu Val Ala Leu Gly Thr Asp Leu Gly Asp Gly Val Phe
675 680 685
Gly Ala Glu Gly Ala Gly Val Val Leu Glu Thr Gly Ser Asp Val Arg
690 695 700
Asp Leu Arg Pro Gly Asp Arg Val Phe Gly Leu Leu Glu Gly Gly His
705 710 715 720
Gly Ser Ile Ala Ile Ala Asp Arg Arg Met Leu Ala Val Ile Pro Glu
725 730 735
Gly Trp Ser Phe Ala Thr Ala Ala Ser Val Pro Glu Val Phe Val Ile
740 745 750
Ala Tyr Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser
755 760 765
Val Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala Thr Gln
770 775 780
Ile Ala Arg His Leu Gly Ala Gln Val Tyr Ala Thr Ala Gly Val Gly
785 790 795 800
Lys Gln His Ile Leu Arg Asp Ala Gly Leu Gly Asp Asp Arg Ile Ala
805 810 815
Asp Ser Arg Thr Thr Asp Phe Arg Glu Ala Phe Arg Asp Ser Thr Gln
820 825 830
Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Lys Gly Asp Phe Val
835 840 845
Asp Ala Ser Leu Asp Leu Leu Ala Asp Gly Gly Arg Phe Leu Glu Leu
850 855 860
Gly Gln Thr Asp Ile Arg Asp Ala Gly Glu Ile Ala Ala Glu Arg Pro
865 870 875 880
Gly Thr Thr Tyr His Ser Phe Thr Arg Met Asn Ala Gly Pro Asp Arg
885 890 895
Leu Arg Glu Ile Ile Ala Glu Leu Leu Ala Leu Phe Glu Gln Gly Val
900 905 910
Leu Arg Pro Ser Pro Val His Thr Trp Asp Ile Arg His Ala Arg Glu
915 920 925
Ala Phe Ser Trp Met Ser Gly Gly Arg His Thr Gly Lys Met Val Leu
930 935 940
Thr Met Pro Gln Arg Ile Asp Pro Gly Gly Thr Val Leu Ile Ala Gly
945 950 955 960
Asp Ser Glu Ala Leu Ala Arg Ile Ala Ala Arg His Leu Gly Val Arg
965 970 975
His Leu Leu Leu Asp Arg Gly Val Ala Asp Ala Ala Pro Asp Ala Val
980 985 990
Val Cys Asp Val Ser Asp His Asp Ala Leu Glu Arg Val Leu Ala Asp
995 1000 1005
Leu Ser Pro Glu His Pro Leu Thr Ala Val Ile His Thr Gly Gly
1010 1015 1020
Ala Ala Val Thr Asp Glu Ile Arg Arg Leu His Asp Leu Thr Glu
1025 1030 1035
Ser Leu Asp Leu Thr Asp Phe Val Val Phe Ser Gln Asp Ala Pro
1040 1045 1050
Ala Ala Val Glu Ala Phe Ala Arg Ser Arg Arg Ala His Gly Leu
1055 1060 1065
Pro Val Arg Thr Ile Ala Trp Gly Ile Pro Glu Ala Asp Pro Val
1070 1075 1080
Val Ala Asp Glu His Leu Leu Gly Arg Ala Leu Ala Ser Ala Glu
1085 1090 1095
Gln Ala Gln Ile Val Ala Arg Val Asn Thr Ala Gly Leu Arg Ala
1100 1105 1110
Leu Thr Ala Ala Asn Ala Leu Pro Thr Leu Leu Arg Asn Leu Ile
1115 1120 1125
Arg Ala Glu Pro Glu Glu Thr Gly Gln Ser Ala Trp Pro His Arg
1130 1135 1140
Phe Glu Ala Ala Gly Ala Asp Arg Glu Glu Ala Leu Leu Asp Leu
1145 1150 1155
Ile Arg Ala Asn Val Val Asp Ile Leu Ser Leu Pro Thr Ala Asp
1160 1165 1170
Arg Tyr Ala Pro Asp Arg Thr Phe Arg Glu Met Gly Ile Asp Ser
1175 1180 1185
Leu Thr Ala Val Gly Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly
1190 1195 1200
Leu Pro Leu Pro Thr Thr Met Val Phe Asp Tyr Pro Thr Pro Ala
1205 1210 1215
Val Leu Thr Ala Arg Met Arg Glu Leu Leu Ala Gly Glu Ser Pro
1220 1225 1230
Ala Pro Ala Arg Thr Ala Ala Arg Ala Val Ala Gln Asp Glu Pro
1235 1240 1245
Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ser
1250 1255 1260
Ser Pro Asp Asp Leu Trp Arg Leu Val Ala Ala Gly Thr Asp Ala
1265 1270 1275
Ile Ser Glu Phe Pro Ala Asp Arg Gly Trp Asp Val Asp Asn Leu
1280 1285 1290
Tyr Asp Pro Asp Pro Asp Ala Pro Gly Lys Thr Tyr Thr Val Leu
1295 1300 1305
Gly Gly Phe Leu Asp Gly Val Ala Gly Phe Asp Ala Ser Phe Phe
1310 1315 1320
Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg
1325 1330 1335
Leu Met Leu Glu Val Ser Trp Glu Ala Phe Glu His Ala Gly Ile
1340 1345 1350
Pro Pro Arg Ser Val Arg Gly Ser Asp Ala Gly Val Phe Met Gly
1355 1360 1365
Ala Phe Pro Ser Gly Tyr Asp Ala Gly Leu Glu Glu Phe Gly Met
1370 1375 1380
Thr Gly Asp Ala Val Ser Val Leu Ser Gly Arg Val Ser Tyr Phe
1385 1390 1395
Phe Gly Leu Glu Gly Pro Ala Ile Thr Val Asp Thr Ala Cys Ser
1400 1405 1410
Ser Ser Leu Val Ala Leu His Gln Ala Ser Ser Ala Leu Arg Gln
1415 1420 1425
Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Leu Ala
1430 1435 1440
Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala
1445 1450 1455
Leu Asp Gly Arg Ser Lys Ala Phe Ala Asp Ala Ala Asp Gly Ala
1460 1465 1470
Gly Trp Ala Glu Gly Val Gly Val Leu Val Val Glu Arg Leu Ser
1475 1480 1485
Asp Ala Arg Ala Lys Gly His Gln Ile Trp Gly Val Ile Arg Gly
1490 1495 1500
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Ser Ala Pro
1505 1510 1515
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn
1520 1525 1530
Ala Gly Leu Ala Pro His Glu Val Asp Val Val Glu Ala His Gly
1535 1540 1545
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile
1550 1555 1560
Ala Thr Tyr Gly Gln Asp Arg Glu Gln Pro Leu Leu Leu Gly Ser
1565 1570 1575
Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Val Ser
1580 1585 1590
Gly Val Ile Lys Met Val Met Ala Leu Gln His Asp Thr Val Pro
1595 1600 1605
Ala Thr Leu His Val Asp Ala Pro Ser Arg His Val Asp Trp Thr
1610 1615 1620
Ala Gly Ala Val Glu Leu Val Thr Glu Asn Arg Pro Trp Pro Glu
1625 1630 1635
Thr Gly Arg Val Arg Arg Ala Gly Val Ser Ser Phe Gly Ile Ser
1640 1645 1650
Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro Glu Gln Pro
1655 1660 1665
Val Ser Pro Pro Glu Ala Val Ala Pro Val Val Ala Ser Asp Arg
1670 1675 1680
Val Pro Leu Val Ile Ser Ala Lys Thr Pro Ala Ala Leu Ala Glu
1685 1690 1695
Met Glu Asn Arg Leu Arg Ala Tyr Leu Ala Ala Ala Pro Gly Ala
1700 1705 1710
Asp Pro Arg Ala Val Ala Ser Thr Leu Ala Thr Ala Arg Ser Val
1715 1720 1725
Phe Glu His Arg Ala Val Leu Leu Gly Glu Asn Thr Ile Thr Gly
1730 1735 1740
Thr Val Ala Gly Ala Asp Pro Arg Val Val Phe Val Phe Pro Gly
1745 1750 1755
Gln Gly Trp Gln Gln Leu Gly Met Gly Arg Ala Leu Arg Glu Ser
1760 1765 1770
Ser Pro Val Phe Ala Ala Arg Met Ala Glu Cys Ala Ala Ala Leu
1775 1780 1785
Ser Glu Phe Val Asp Trp Asp Leu Phe Thr Met Leu Asp Asp Pro
1790 1795 1800
Ala Val Ile Asp Arg Ile Asp Val Leu Gln Pro Ala Cys Trp Ala
1805 1810 1815
Val Met Met Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Val Arg
1820 1825 1830
Pro Asp Ala Val Ile Gly His Ser Gln Gly Glu Ile Ala Ala Ala
1835 1840 1845
Cys Val Ala Gly Ala Leu Ser Leu Arg Asp Ala Ala Arg Ile Val
1850 1855 1860
Ala Leu Arg Ser Gln Leu Leu Ala Arg Glu Met Val Gly His Gly
1865 1870 1875
Val Met Ala Ala Val Ala Leu Pro Ala Asp Asp Ile Pro Leu Val
1880 1885 1890
Asp Gly Val Trp Ile Gly Ala Cys Asn Gly Pro Ser Ser Thr Val
1895 1900 1905
Ile Ser Gly Thr Pro Glu Ala Val Glu Val Val Val Ala Ala Cys
1910 1915 1920
Glu Glu Arg Gly Ala Arg Val Arg Arg Ile Thr Ala Ala Val Ala
1925 1930 1935
Ser His Ser Pro Leu Gly Glu Lys Ile Arg Thr Glu Leu Leu Gly
1940 1945 1950
Ile Ser Ala Ser Ile Pro Ser Arg Thr Pro Val Val Pro Trp Leu
1955 1960 1965
Ser Thr Ala Asp Gly Ile Trp Ile Glu Ala Pro Leu Asp Pro Ala
1970 1975 1980
Tyr Trp Trp Arg Asn Leu Arg Glu Pro Val Gly Phe Gly Pro Ala
1985 1990 1995
Val Asp Leu Leu Gln Ala Arg Gly Glu Asn Val Phe Leu Glu Met
2000 2005 2010
Ser Ala Ser Pro Val Leu Leu Pro Ala Met Asn Asp Ala Val Thr
2015 2020 2025
Val Ala Thr Leu Arg Arg Asp Asp Gly Thr Pro Asp Arg Met Leu
2030 2035 2040
Thr Ala Leu Ala Glu Ala His Ala His Gly Val Ile Val Asp Trp
2045 2050 2055
Pro Arg Val Phe Gly Ser Thr Thr Arg Val Leu Asp Leu Pro Thr
2060 2065 2070
Tyr Ala Phe Glu His Gln Arg Tyr Trp Ala Val Ser Ala Asp Arg
2075 2080 2085
Pro Ser Asp Ala Gly His Pro Met Val Glu Thr Val Val Pro Leu
2090 2095 2100
Pro Ala Ser Gly Gly Val Ala Leu Thr Gly Arg Val Ser Leu Ala
2105 2110 2115
Thr His Ala Trp Leu Ala Asp His Ala Val Arg Gly Thr Ala Leu
2120 2125 2130
Leu Pro Gly Thr Ala Phe Val Glu Leu Val Thr Arg Ala Ala Thr
2135 2140 2145
Glu Val Asp Cys Pro Val Ile Asp Glu Leu Val Ile Glu Ala Pro
2150 2155 2160
Leu Pro Leu Thr Gln Thr Gly Ala Val Gln Leu Ser Thr Thr Val
2165 2170 2175
Gly Glu Ala Asp Glu Ser Gly Arg Arg Pro Val Thr Val Phe Ser
2180 2185 2190
Gln Ala Asp Gly Thr Asp Ala Trp Thr Arg His Val Thr Ala Thr
2195 2200 2205
Ile Gly Arg Ala Ala Ser Leu Pro Asp Pro Val Ala Trp Pro Pro
2210 2215 2220
Ala Gln Ala Glu Pro Val Asp Val Thr Gly Phe Tyr Asp Glu Leu
2225 2230 2235
Ala Ala Ala Gly Tyr Glu Tyr Gly Pro Ala Phe Gln Gly Leu Arg
2240 2245 2250
Ala Ala Trp Ser Asp Gly Asp Thr Val Tyr Ala Glu Val Val Leu
2255 2260 2265
Ala Glu Glu Gln Ala His Glu Val Asp Arg Tyr Ala Val His Pro
2270 2275 2280
Ala Leu Leu Asp Ala Ala Leu Gln Ala Gly Met Val Asn Thr Ala
2285 2290 2295
Gly Thr Gly Gln Gly Val Arg Leu Pro Phe Ser Trp Asn Gly Ile
2300 2305 2310
Gln Val His Ser Thr Gly Ala Thr Thr Leu Arg Val Ala Ala Thr
2315 2320 2325
Pro Leu Ala Asp Gly Trp Ser Val Arg Ala Ala Ala Asp Asn Gly
2330 2335 2340
Arg Pro Val Ala Thr Ile Gly Ser Leu Val Thr Arg Pro Val Thr
2345 2350 2355
Thr Asp Met Leu Gly Ser Thr Thr Asp Asp Leu Phe Ala Val Val
2360 2365 2370
Trp Thr Glu Ile Thr Ala Pro Glu Pro Gly Asp Pro Ser Asp Val
2375 2380 2385
Gly Val Phe Thr Ala Leu Pro Glu Ala Gly Gly Asp Pro Leu Thr
2390 2395 2400
Gln Thr Arg Ala Leu Thr Ala Gln Val Leu Gln Thr Val Gln Gln
2405 2410 2415
Trp Leu Ala Gly Glu Asp Arg Pro Leu Val Val Arg Thr Gly Thr
2420 2425 2430
Asp Leu Ala Ser Ala Ala Val Ser Gly Leu Val Arg Ser Ala Gln
2435 2440 2445
Ser Glu His Pro Gly Arg Leu Ile Leu Val Glu Ser Asp Asp Glu
2450 2455 2460
Leu Thr Pro Glu Gln Leu Ala Gly Thr Ala Gly Leu Asp Glu Pro
2465 2470 2475
Arg Ile Arg Ile Asp Gly Gly His Tyr Glu Val Pro Arg Leu Ala
2480 2485 2490
Arg Glu Asp Ala Ser Leu Thr Val Pro Glu Asp Arg Ala Trp Leu
2495 2500 2505
Leu Glu Leu Pro Gly Ser Gly Thr Leu Arg Asp Leu Arg Val Ile
2510 2515 2520
Pro Thr Asp Thr Ala Glu Arg Pro Leu Arg Trp Gly Glu Val Arg
2525 2530 2535
Val Gly Val Arg Ala Gly Gly Leu Asn Phe Arg Asp Val Val Val
2540 2545 2550
Ala Leu Gly Met Val Thr Asp Pro Arg Pro Ala Gly Gly Glu Ala
2555 2560 2565
Ala Gly Val Val Leu Glu Thr Gly Pro Gly Val Glu Asp Leu Ser
2570 2575 2580
Pro Gly Asp Arg Val Phe Gly Ile Leu Asp Gly Gly Phe Gly Ser
2585 2590 2595
Val Ala Ile Ala Asp Arg Arg Leu Leu Ala Val Ile Pro Asp Gly
2600 2605 2610
Trp Ser Phe Thr Thr Ala Ala Ser Ile Pro Val Val Phe Ala Thr
2615 2620 2625
Ala Tyr Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu
2630 2635 2640
Ser Val Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala
2645 2650 2655
Thr Gln Ile Ala Arg His Leu Gly Ala Glu Ile Tyr Gly Thr Ala
2660 2665 2670
Gly Ile Ala Lys Gln His Val Leu Arg Asp Ala Gly Leu Gly Asp
2675 2680 2685
Asp Arg Ile Ala Asp Ser Arg Thr Thr Gly Phe Arg Glu Thr Phe
2690 2695 2700
Arg Asp Ser Thr Gln Gly Arg Gly Val Asp Val Val Leu Asn Ser
2705 2710 2715
Leu Ser Gly Asp Phe Val Asp Ala Ser Leu Asp Val Leu Ala Glu
2720 2725 2730
Gly Gly Arg Phe Ile Glu Met Gly Lys Thr Asp Ile Arg Asp Ala
2735 2740 2745
Glu Gln Ile Thr His Ala Thr Tyr Arg Ala Phe Asp Leu Met Asp
2750 2755 2760
Ala Gly Pro Asp Arg Val Arg Glu Ile Ile Ala Glu Leu Leu Gly
2765 2770 2775
Leu Phe Glu Gln Gly Val Leu Arg Pro Leu Pro Val Gln Ala Trp
2780 2785 2790
Asp Ile Arg Gln Ala Arg Asp Ala Phe Thr Trp Met Ser Arg Ala
2795 2800 2805
Arg His Ile Gly Lys Ile Val Leu Thr Ile Pro Gln Gln Leu Asp
2810 2815 2820
Pro Asp Gly Thr Val Leu Ile Ser Gly Gly Ser Gly Val Leu Ala
2825 2830 2835
Gly Ile Leu Ala Arg His Leu Val Ala Glu Arg Gly Val Arg His
2840 2845 2850
Leu Leu Leu Val Ser Arg Ser Ala Pro Ser Glu Ala Leu Ile Ser
2855 2860 2865
Glu Leu Thr Ala Leu Gly Ala Gln Val Glu Thr Val Ala Cys Asp
2870 2875 2880
Val Ser Asp Arg Val Ala Leu Glu Gln Val Leu Asp Gly Val Pro
2885 2890 2895
Leu Thr Ala Val Phe His Thr Ala Ala Ala Leu Asp Asp Gly Val
2900 2905 2910
Val Glu Ser Leu Thr Pro Gln Arg Val Asp Thr Val Leu Arg Pro
2915 2920 2925
Lys Ala Asp Ala Ala Trp Tyr Leu His Glu Leu Thr Arg Asp Ala
2930 2935 2940
Asp Leu Ala Ala Phe Val Met Tyr Ser Ser Val Ala Gly Ile Met
2945 2950 2955
Gly Ala Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala Phe Leu
2960 2965 2970
Asp Ala Leu Ala Ala His Arg Arg Arg Glu Gly Leu Pro Ala Leu
2975 2980 2985
Ser Leu Ala Trp Gly Leu Trp Glu Asp Ala Ser Gly Leu Ser Ala
2990 2995 3000
Gly Leu Thr Glu Thr Asp His Asp Arg Ile Arg Arg Gly Gly Leu
3005 3010 3015
Glu Ala Ile Ala Ala Glu His Gly Met Arg Leu Phe Asp Thr Ala
3020 3025 3030
Thr Arg Gln Gly Glu Pro Val Leu Leu Ala Ser Pro Leu Asn Leu
3035 3040 3045
Thr Arg Gln Gly Glu Val Pro Ala Leu Leu Arg Thr Leu His Arg
3050 3055 3060
Pro Val Ala Arg Arg Ala Ala Thr Ala Asn Gly Arg Pro Ala Asp
3065 3070 3075
Leu Thr Pro Glu Ala Leu Leu Lys Leu Val Cys Gly Arg Ala Ala
3080 3085 3090
Ala Val Leu Gly His Val Asp Ala Asp Ala Val Pro Val Ala Val
3095 3100 3105
Ala Phe Arg Asp Leu Gly Val Asp Ser Leu Thr Ala Val Glu Leu
3110 3115 3120
Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr
3125 3130 3135
Leu Val Phe Asp Tyr Pro Thr Pro Thr Val Leu Ala Gly Arg Leu
3140 3145 3150
Gly Glu Leu Leu Ala Gly Gly Thr Ala Pro Val Arg Ala Ala Val
3155 3160 3165
Val Arg Arg Ala Ala Ala Ser Asp Glu Pro Leu Ala Ile Val Gly
3170 3175 3180
Met Ala Cys Arg Leu Pro Gly Gly Val Leu Ser Pro Glu Asp Leu
3185 3190 3195
Trp Arg Leu Val Glu Ser Gly Gly Asp Ala Ile Ser Gly Phe Pro
3200 3205 3210
Val Asp Arg Gly Trp Asp Val Glu Asn Leu Phe Asp Pro Asp Pro
3215 3220 3225
Asp Ala Ala Gly Arg Thr Tyr Ala Val Arg Gly Gly Phe Leu Asp
3230 3235 3240
Gly Ala Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg
3245 3250 3255
Glu Ala Gln Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Val
3260 3265 3270
Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val
3275 3280 3285
Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly
3290 3295 3300
Tyr Gly Val Gly Thr Asp Leu Gly Gly Phe Gly Met Thr Ser Val
3305 3310 3315
Ala Val Ser Val Leu Ala Gly Arg Val Ser Tyr Phe Phe Gly Leu
3320 3325 3330
Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu
3335 3340 3345
Val Ala Leu His Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys
3350 3355 3360
Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Pro Thr Pro Gln
3365 3370 3375
Thr Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly
3380 3385 3390
Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr Gly Phe Ser
3395 3400 3405
Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Gln
3410 3415 3420
Ala Arg Gly His Asn Ile Leu Ala Val Val Arg Gly Ser Ala Val
3425 3430 3435
Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro
3440 3445 3450
Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu
3455 3460 3465
Ala Gly Ala Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr
3470 3475 3480
Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr
3485 3490 3495
Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys Ser
3500 3505 3510
Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile
3515 3520 3525
Lys Met Val Met Ala Leu Arg His Asp Thr Val Pro Ala Thr Leu
3530 3535 3540
His Ile Asp Glu Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala
3545 3550 3555
Val Glu Leu Val Thr Glu Asn Gln Ser Trp Pro Glu Thr Gly Arg
3560 3565 3570
Ala Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn
3575 3580 3585
Ala His Val Ile Leu Glu Ser Ala Pro Ala Gln Pro Val Pro Leu
3590 3595 3600
Val Asp Thr Pro Val Ser Ala Val Thr Ala Gly Val Val Pro Leu
3605 3610 3615
Pro Ile Ser Ala Arg Thr Val Pro Ala Leu Ala Asp Leu Glu Asp
3620 3625 3630
Arg Leu Arg Ala Tyr Leu Thr Thr Thr Pro Glu Thr Asp Leu Pro
3635 3640 3645
Ala Val Ala Ser Thr Leu Ala Val Thr Arg Ser Val Phe Glu His
3650 3655 3660
Arg Ala Val Leu Leu Gly Glu Glu Thr Val Thr Gly Ile Ala Val
3665 3670 3675
Ser Asp Pro Arg Val Val Phe Val Phe Ser Gly Gln Gly Ser Gln
3680 3685 3690
Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Leu Phe
3695 3700 3705
Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp Val Pro Asp
3710 3715 3720
Leu Glu Val Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu Phe Ala
3725 3730 3735
Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg
3740 3745 3750
Pro Glu Ala Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly
3755 3760 3765
Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys Thr Leu Val
3770 3775 3780
Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala
3785 3790 3795
Met Val Ala Val Pro Val Ser Glu Glu Arg Ala Arg Ala Val Leu
3800 3805 3810
Val Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val
3815 3820 3825
Val Leu Ser Gly Asp Glu Ser Ala Val Leu Arg Val Ala Glu Gly
3830 3835 3840
Leu Gly Arg Trp Thr Arg Leu Ser Ala Ser His Ala Phe His Ser
3845 3850 3855
Val Arg Met Glu Pro Met Leu Glu Glu Phe Arg Gln Val Ala Ser
3860 3865 3870
Glu Leu Thr Tyr Arg Glu Pro Arg Ile Val Met Ala Ala Gly Glu
3875 3880 3885
Gln Val Thr Thr Pro Glu Tyr Trp Val Arg Gln Val Arg Asp Thr
3890 3895 3900
Val Arg Phe Gly Asp Gln Val Ala Ala Phe Gly Asp Ala Val Phe
3905 3910 3915
Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu Ile Asp Gly
3920 3925 3930
Ile Pro Thr Leu His Gly Asp Asp Glu Gln His Ala Val Val Ala
3935 3940 3945
Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile Asp Trp Ser
3950 3955 3960
Ser Ile Leu Gly Ala Asn Pro Ala Arg Val Leu Asp Leu Pro Thr
3965 3970 3975
Tyr Ala Phe Gln His Glu Arg Tyr Trp Met Val Ser Thr Gly Arg
3980 3985 3990
Val Gly Gly Glu Gly His Pro Leu Leu Gly Trp Gly Val Pro Val
3995 4000 4005
Ala Glu Ala Gly Gly Arg Leu Tyr Thr Gly Arg Val Ala Arg Gln
4010 4015 4020
Asp Gly Pro Val Leu Ser Val Ala Ala Phe Val Glu Met Ala Phe
4025 4030 4035
Ala Ala Ala Gly Gly Arg Pro Ile Arg Glu Leu Ser Val Asp Ala
4040 4045 4050
Leu Leu Tyr Ile Pro Asp Asp Gly Thr Ala Glu Leu Gln Thr Trp
4055 4060 4065
Val Ser Glu His Arg Leu Thr Ile His Ala Arg Tyr Arg Asp Thr
4070 4075 4080
Glu Pro Trp Thr Arg Leu Ala Thr Ala Ala Leu Asp Thr Thr Ala
4085 4090 4095
Pro Ala Thr Thr His Thr Pro His Pro Gly Leu Ile Thr Thr Ala
4100 4105 4110
Leu Thr Leu Thr Gly Asp Glu Ala Pro Ala Ile Trp His Asp Leu
4115 4120 4125
Thr Leu His Thr Ser Asn Ala Thr Glu Leu His Thr His Ile Thr
4130 4135 4140
Pro Gly Asp Asp Gly Thr Leu Thr Ile Thr Ala Thr Asp Thr Thr
4145 4150 4155
Gly Gln Pro Val Leu Thr Ala His Thr Ala Thr Pro Thr Thr Ile
4160 4165 4170
Pro Val His Thr Pro Thr Thr Pro Ala Asp Asp Leu Leu Thr Leu
4175 4180 4185
Thr Trp Thr Gln Ile Pro Thr Pro Gly Pro Gly Asp Pro Thr Asp
4190 4195 4200
Ile Ala Val Cys Thr Ala Leu Pro Asp Pro Asp Gly Asp Pro Leu
4205 4210 4215
Ala Gln Thr Arg Thr Leu Thr Ala Gln Val Leu Gln Ser Ile Gln
4220 4225 4230
Thr Thr Leu Thr Gly Glu Asp Arg Pro Leu Val Val His Thr Gly
4235 4240 4245
Thr Gly Leu Ala Ser Ala Ala Val Ser Gly Leu Val Arg Ser Ala
4250 4255 4260
Gln Ser Glu His Pro Asp Arg Phe Ile Leu Val Glu Ser Asp Asp
4265 4270 4275
Ser Leu Pro Gln Ala Gln Leu Ala Ala Val Ala Gly Leu Asp Glu
4280 4285 4290
Pro Trp Leu Arg Ile Thr Gly Ser Cys Tyr Glu Val Pro Arg Leu
4295 4300 4305
Thr Lys Thr Thr Thr Ala Thr Ala Thr Ala Val Ser Glu Pro Val
4310 4315 4320
Trp Asn Pro Asp Gly Thr Val Leu Ile Thr Gly Gly Ser Gly Ala
4325 4330 4335
Leu Ala Gly Ile Leu Ala Arg His Leu Val Thr Glu Arg Gly Val
4340 4345 4350
Arg His Leu Leu Leu Ile Ser Arg Ser Thr Pro Ser Thr Thr Leu
4355 4360 4365
Thr Asp Glu Leu Arg Glu Leu Gly Ala His Val Asp Val Ala Ala
4370 4375 4380
Cys Asp Val Ser Asp Arg Asp Ala Leu Ala Arg Val Leu Asp Gly
4385 4390 4395
Val Asp Leu Thr Ala Val Phe His Thr Ala Gly Ala Leu Asp Asp
4400 4405 4410
Gly Val Val Glu Ser Leu Thr Pro Gln Arg Leu Asp Thr Val Leu
4415 4420 4425
Thr Pro Lys Ala Asp Gly Ala Trp His Leu His Glu Leu Thr Arg
4430 4435 4440
Asp Arg Asp Leu Thr Ala Phe Val Met Tyr Ser Ser Ala Ala Gly
4445 4450 4455
Val Met Gly Ala Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala
4460 4465 4470
Phe Leu Asp Ala Leu Ala Glu His Arg His Ala Asp Gly Leu Pro
4475 4480 4485
Ala Leu Ser Leu Ala Trp Gly Met Trp Asp Asp Thr Asp Gly Met
4490 4495 4500
Thr Ala Ser Leu Ser Gly Thr Asp His Arg Arg Ile Arg Arg Ser
4505 4510 4515
Gly Gln Arg Ala Ile Thr Ala Glu His Gly Met Arg Leu Leu Asp
4520 4525 4530
Lys Ala Ser Gly Arg Ser Glu Pro Val Leu Val Ala Thr Ala Met
4535 4540 4545
Asn Pro Ile Pro Asp Thr Asp Leu Pro Ala Leu Leu Arg Ser Leu
4550 4555 4560
Tyr Pro Lys Thr Ala Arg Lys Ser Gln Pro Ile Gln Glu Leu Ser
4565 4570 4575
Pro Glu Ala Leu Leu Lys Ile Val Arg Asp Ser Ala Ala Leu Met
4580 4585 4590
Leu Gly His Pro Asn Thr Asp Ala Ile Ala Ala Thr Thr Ala Phe
4595 4600 4605
Arg Asp Leu Gly Val Asp Ser Leu Ile Ala Val Glu Leu Arg Asn
4610 4615 4620
Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val
4625 4630 4635
Phe Asp Tyr Pro Thr Pro Thr Val Leu Ala Gly Arg Leu Gly Glu
4640 4645 4650
Leu Leu Ala Gly Val Thr Pro Gln Arg His Ala Thr Val Arg Thr
4655 4660 4665
Gly Thr Ala Ser Asp Glu Pro Leu Ala Ile Val Gly Met Ala Cys
4670 4675 4680
Arg Leu Pro Gly Gly Val Ser Ser Pro Glu Asp Leu Trp Arg Leu
4685 4690 4695
Val Glu Ser Gly Thr Asp Ala Ile Thr Asp Phe Pro Thr Asp Arg
4700 4705 4710
Gly Trp Asp Thr Asp Asp Leu Phe Asp Pro Asp Pro Asp Thr Ala
4715 4720 4725
Gly Lys Thr Tyr Thr Val His Gly Gly Phe Leu Asp Asp Val Ala
4730 4735 4740
Gly Phe Asp Ala Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Gln
4745 4750 4755
Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ala Ala Trp Glu
4760 4765 4770
Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser Val Arg Gly Ser
4775 4780 4785
Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Gly Gly Tyr Gly Ile
4790 4795 4800
Gly Ala Asp Leu Gly Gly Phe Gly Ala Thr Ala Gly Ala Gly Ser
4805 4810 4815
Val Leu Ser Gly Arg Leu Ser Tyr Phe Phe Gly Leu Glu Gly Pro
4820 4825 4830
Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu
4835 4840 4845
His Gln Ala Gly Ser Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala
4850 4855 4860
Leu Val Gly Gly Val Thr Val Ile Ala Asn Pro Gln Ile Phe Val
4865 4870 4875
Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys
4880 4885 4890
Ala Phe Ala Asp Ser Ala Asp Gly Thr Gly Trp Ser Glu Gly Val
4895 4900 4905
Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly
4910 4915 4920
His Asn Ile Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp
4925 4930 4935
Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln
4940 4945 4950
Arg Val Ile Arg Gln Ala Leu Ala Asn Ala Gly Leu Ala Gly Ala
4955 4960 4965
Glu Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu Gly
4970 4975 4980
Asp Pro Ile Glu Ala Gln Ala Val Ile Ala Thr Tyr Gly Gln Asp
4985 4990 4995
Arg Asp Gln Ser Val Leu Leu Gly Ser Leu Lys Ser Asn Leu Gly
5000 5005 5010
His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met Val
5015 5020 5025
Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu His Ala Asp
5030 5035 5040
Gln Pro Ser Arg His Ile Asp Trp Thr Ala Gly Ala Val Glu Leu
5045 5050 5055
Val Thr Glu Asn Gln Pro Trp Pro Glu Leu Asp Arg Pro Arg Arg
5060 5065 5070
Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val
5075 5080 5085
Ile Leu Glu Ser Ala Pro Asp Gln Pro Val Pro Leu Val Asp Thr
5090 5095 5100
Pro Val Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser
5105 5110 5115
Ala Arg Thr Val Pro Ala Leu Ala Asp Leu Glu Asp Gln Leu Arg
5120 5125 5130
Ala Tyr Leu Thr Thr Ala Pro Glu Thr Asp Leu Pro Ala Val Ala
5135 5140 5145
Ser Thr Leu Ala Thr Thr Arg Ser Val Phe Glu His Arg Ala Val
5150 5155 5160
Leu Leu Gly Glu Asp Thr Val Thr Gly Thr Ala Ile Pro Asp Pro
5165 5170 5175
Arg Ile Val Phe Val Phe Ser Gly Gln Gly Ser Gln Arg Ala Gly
5180 5185 5190
Met Gly Glu Glu Leu Ala Ala Ala Phe Pro Leu Phe Ala Arg Leu
5195 5200 5205
His Arg Gln Val Trp Asp Leu Leu Asp Val Pro Asp Leu Asp Val
5210 5215 5220
Asp Asp Thr Gly Tyr Val Gln Pro Ala Leu Phe Ala Leu Gln Val
5225 5230 5235
Ala Leu Phe Gly Leu Leu Glu Ser Trp Gly Val Arg Pro Arg Ala
5240 5245 5250
Val Ile Gly His Ser Val Gly Glu Val Ala Ala Gly Tyr Val Ala
5255 5260 5265
Gly Val Trp Ser Leu Glu Asp Ala Cys Ala Leu Val Ser Ala Arg
5270 5275 5280
Ala Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Val Ala
5285 5290 5295
Val Pro Val Ser Glu Glu Arg Ala Arg Ala Val Leu Val Asp Gly
5300 5305 5310
Val Glu Ile Ala Ala Val Asn Gly Pro Ala Ser Val Val Leu Ser
5315 5320 5325
Gly Asp Glu Ala Ala Val Leu Arg Val Ala Glu Gly Leu Gly Arg
5330 5335 5340
Trp Thr Arg Leu Ser Ala Ser His Ala Phe His Ser Val Arg Met
5345 5350 5355
Glu Pro Met Leu Glu Glu Phe Arg Gln Val Val Ser Arg Leu Thr
5360 5365 5370
Tyr Arg Glu Pro Arg Ile Val Met Ala Ala Gly Glu Gln Val Thr
5375 5380 5385
Thr Pro Glu Tyr Trp Val Arg Gln Val Arg Glu Thr Val Arg Phe
5390 5395 5400
Gly Asp Gln Val Ala Ala Phe Gly Asp Ala Val Phe Leu Glu Ile
5405 5410 5415
Gly Pro Asp Arg Thr Leu Ser Arg Leu Ile Asp Gly Ile Ala Met
5420 5425 5430
Leu Asp Gly Asp Asp Glu Val Arg Ala Ala Val Ala Ala Leu Ala
5435 5440 5445
Met Met His Val Gln Gly Val Gly Val Asp Trp Pro Ala Ile Leu
5450 5455 5460
Gly Thr Thr Thr Gly Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe
5465 5470 5475
Gln His Glu Arg Tyr Trp Met Ala Asn Ala Asp Glu Gly His Pro
5480 5485 5490
Leu Leu Gly Lys Val Glu His Pro Leu Leu Gly Ser Val Met Ala
5495 5500 5505
Leu Pro Asn Ser Asp Gly Val Val Leu Thr Gly Arg Ile Ser Leu
5510 5515 5520
Ala Thr His Ala Trp Leu Ala Asp His Val Val Arg Gly Thr Val
5525 5530 5535
Leu Leu Pro Gly Thr Gly Phe Val Glu Met Val Ala Arg Ala Ala
5540 5545 5550
Ala Glu Val Gly Cys Gly Val Ile Asp Glu Leu Leu Ile Glu Ala
5555 5560 5565
Pro Leu Leu Leu Pro Glu His Gly Gly Val His Leu Ser Val Ser
5570 5575 5580
Val Gly Glu Ala Asp Gly Ala Gly Arg Arg Pro Val Thr Val Phe
5585 5590 5595
Ala Gln Ala Asp Asp Ala Glu Val Trp Val Arg Gln Val Thr Ala
5600 5605 5610
Thr Ile Ser Pro Ala Gly Pro Ala Val Ser Leu Pro Glu Leu Glu
5615 5620 5625
Val Trp Pro Pro Val Gln Ala Glu Pro Val Asp Val Ser Thr Phe
5630 5635 5640
Tyr Glu Arg Leu Ala Arg Ala Asp Trp Gln Trp Gly Pro Ala Phe
5645 5650 5655
Gln Gly Leu Arg Ala Ala Trp Arg Asp Gly Asp Thr Ile Tyr Ala
5660 5665 5670
Glu Ile Val Leu Ala Asp Glu Glu Ala Arg Glu Ala Asp Gln Phe
5675 5680 5685
Leu Val His Pro Ala Leu Leu Asp Ala Ala Leu Gln Thr Ser Val
5690 5695 5700
Leu Lys Thr Pro Asp Asp Leu Arg Leu Pro Phe Ser Trp Asn Gln
5705 5710 5715
Ile Glu Phe His Ala Thr Gly Ala Ala Ile Leu Arg Val Ala Val
5720 5725 5730
Thr Pro Val Ala Asp Arg Trp Ile Val His Ala Ala Asp Ser Thr
5735 5740 5745
Gly Arg Pro Val Ala Thr Ile Gly Ala Leu Val Ser Arg Pro Val
5750 5755 5760
Thr Ala Glu Thr Leu Gly Ser Asn Thr Asp Asp Leu Phe Ala Leu
5765 5770 5775
Thr Trp Thr Glu Ile Pro Thr Pro Gly Pro Gly Asp Pro Ala Asp
5780 5785 5790
Val Ala Val Cys Thr Ala Leu Pro Glu Pro Asp Ser Asp Pro Leu
5795 5800 5805
Thr Gln Thr Arg Thr Leu Thr Ala Gln Val Leu Gln Ser Ile Gln
5810 5815 5820
Thr Ser Leu Thr Gly Glu Asp Arg Pro Leu Val Val His Thr Gly
5825 5830 5835
Thr Gly Leu Ala Ser Ala Ala Val Ser Gly Leu Val Arg Ser Ala
5840 5845 5850
Gln Ser Glu His Pro Asp Arg Phe Ile Leu Val Glu Cys Asp Asp
5855 5860 5865
Glu Thr Leu Thr Pro Asp Gln Leu Ala Ala Thr Ala Gly Leu Asp
5870 5875 5880
Glu Pro Trp Leu Arg Ile Thr Gly Gly His Tyr Glu Val Pro Arg
5885 5890 5895
Leu Thr Lys Thr Thr Thr Ala Ala Ala Thr Thr Val Ser Glu Pro
5900 5905 5910
Val Trp Asp Pro Asp Gly Thr Val Leu Ile Thr Gly Gly Ser Gly
5915 5920 5925
Ala Leu Ala Gly Ile Leu Ala Arg His Leu Val Thr Glu Arg Ser
5930 5935 5940
Val Arg His Leu Leu Leu Ile Ser Arg Ser Thr Pro Ser Thr Thr
5945 5950 5955
Leu Ile Asn Glu Leu Arg Glu Leu Gly Ala His Ile Glu Thr Ala
5960 5965 5970
Ala Cys Asp Val Ser Asp Arg Asp Ala Leu Ala Arg Val Leu Asp
5975 5980 5985
Gly Val Asp Leu Thr Ala Val Phe His Thr Ala Gly Ala Leu Asp
5990 5995 6000
Asp Gly Val Val Glu Ser Leu Thr Pro Gln Arg Leu Asp Thr Val
6005 6010 6015
Leu Met Pro Lys Ala Asp Ala Ala Trp His Leu His Glu Leu Thr
6020 6025 6030
Arg Asp Arg Asp Leu Ala Ala Phe Val Met Tyr Ser Ser Ala Ala
6035 6040 6045
Gly Val Met Gly Ala Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn
6050 6055 6060
Ala Phe Leu Asp Ala Leu Ala Glu His Arg Arg Ala Asp Gly Leu
6065 6070 6075
Pro Ala Leu Ser Leu Ala Trp Gly Met Trp Asp Asp Ala Asp Gly
6080 6085 6090
Met Thr Ala Ser Leu Ser Gly Thr Asp His Arg Arg Ile Arg Arg
6095 6100 6105
Ser Gly Gln Arg Ala Ile Thr Ala Glu His Gly Met Arg Leu Leu
6110 6115 6120
Asp Lys Ala Ser Gly Arg Ser Glu Pro Val Leu Val Ala Thr Ala
6125 6130 6135
Met Asn Pro Ala Gly Glu Gly Glu Val Pro Ala Leu Leu Arg Thr
6140 6145 6150
Leu His Arg Pro Val Ala Arg Arg Ala Ala Thr Thr Asn Gly Arg
6155 6160 6165
Pro Ala Asp Leu Thr Pro Glu Ala Leu Leu Lys Val Val Arg Asp
6170 6175 6180
Ser Ala Ala Val Val Leu Gly His Ala Ser Ala Asp Thr Val Pro
6185 6190 6195
Ala Ala Thr Ala Phe Gln Glu Leu Gly Leu Asp Ser Leu Ile Ala
6200 6205 6210
Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr Gly Leu Arg Leu
6215 6220 6225
Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ala Leu Ala
6230 6235 6240
Gly Arg Leu Gly Glu Leu Leu Ala Gly Glu Thr Thr Pro Ala Thr
6245 6250 6255
Ala Ala Val Val Arg Arg Ala Thr Ala Ser Asp Glu Pro Leu Ala
6260 6265 6270
Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val Ser Ser Pro
6275 6280 6285
Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Phe Asp Ala Ile Thr
6290 6295 6300
Gly Phe Pro Thr Asp Arg Gly Trp Asp Val Asp Asn Leu Tyr Asp
6305 6310 6315
Pro Asp Pro Asp Ala Pro Gly Lys Ser Thr Thr Leu His Gly Gly
6320 6325 6330
Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe Phe Gly Ile
6335 6340 6345
Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Ala
6350 6355 6360
Met Glu Val Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro
6365 6370 6375
Gly Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Tyr
6380 6385 6390
Pro Gly Gly Tyr Gly Ile Gly Ala Glu Leu Gly Gly Phe Met Leu
6395 6400 6405
Thr Gly Arg Ala Gly Ser Val Leu Ala Gly Arg Val Ser Tyr Phe
6410 6415 6420
Phe Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr Ala Cys Ser
6425 6430 6435
Ser Ser Leu Val Ala Leu His Gln Ala Ala Tyr Ala Leu Arg Gln
6440 6445 6450
Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr Val Met Pro
6455 6460 6465
Thr Pro Val Met Phe Val Glu Phe Ser Gln Gln Gln Asn Leu Ala
6470 6475 6480
Asp Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp Gly Thr
6485 6490 6495
Gly Trp Ser Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser
6500 6505 6510
Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala Val Val Arg Gly
6515 6520 6525
Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro
6530 6535 6540
Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Ser Ala Leu Thr Ser
6545 6550 6555
Ala Gly Leu Thr Thr Ala Asp Val Asp Val Val Glu Ala His Gly
6560 6565 6570
Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Leu
6575 6580 6585
Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu Leu Gly Ser
6590 6595 6600
Leu Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser
6605 6610 6615
Gly Val Ile Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro
6620 6625 6630
Arg Thr Leu His Val Glu Glu Pro Ser Arg His Val Asp Trp Thr
6635 6640 6645
Ala Gly Ala Val Glu Leu Val Thr Glu Asn Gln Ser Trp Pro Glu
6650 6655 6660
Thr Gly Arg Ala Arg Arg Ala Ala Val Ser Ser Phe Gly Phe Ser
6665 6670 6675
Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro Ala Gln Pro
6680 6685 6690
Val Pro Pro Met Asp Thr Pro Ala Pro Ala Val Thr Thr Gly Val
6695 6700 6705
Val Pro Leu Pro Ile Ser Ala Lys Ser Leu Pro Ala Leu Ala Asp
6710 6715 6720
Leu Glu Asp Gln Leu Arg Ala Tyr Leu Thr Ala Thr Pro Glu Thr
6725 6730 6735
Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met Thr Arg Ser Val
6740 6745 6750
Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu Thr Val Thr Gly
6755 6760 6765
Thr Ala Ile Pro Asp Pro Arg Ile Val Phe Val Phe Ser Gly Gln
6770 6775 6780
Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu Ala Ala Ala Phe
6785 6790 6795
Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp Asp Leu Leu Asp
6800 6805 6810
Val Pro Asp Leu Asp Val Asp Asp Thr Gly Tyr Val Gln Pro Ala
6815 6820 6825
Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu Leu Glu Ser Trp
6830 6835 6840
Gly Val Arg Pro Arg Ala Val Ile Gly His Ser Val Gly Glu Val
6845 6850 6855
Ala Ala Gly Tyr Val Ala Gly Val Trp Ser Leu Glu Asp Ala Cys
6860 6865 6870
Ala Leu Val Ser Ala Arg Ala Arg Leu Met Gln Ala Leu Pro Ala
6875 6880 6885
Gly Gly Ala Met Val Ala Val Pro Val Ser Glu Glu Arg Ala Arg
6890 6895 6900
Val Ala Leu Val Asp Gly Val Glu Ile Ala Ala Val Asn Gly Pro
6905 6910 6915
Ala Ser Val Val Leu Ser Gly Asp Glu Ala Ala Val Leu Gln Ile
6920 6925 6930
Ala Glu Gly Leu Gly Arg Trp Thr Arg Leu Ser Ala Ser His Ala
6935 6940 6945
Phe His Ser Val Arg Met Glu Pro Met Leu Glu Glu Phe Gly Gln
6950 6955 6960
Val Ala Ser Glu Leu Thr Tyr Gln Glu Pro Arg Ile Val Met Ala
6965 6970 6975
Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp Val Arg Gln Val
6980 6985 6990
Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala Ala Phe Gly Asp
6995 7000 7005
Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr Leu Ser Arg Leu
7010 7015 7020
Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp Glu Val Arg Ala
7025 7030 7035
Ala Val Ala Ala Leu Ala Glu Leu His Val Gln Gly Val Pro Ile
7040 7045 7050
Asp Trp Pro Ala Val Leu Gly Thr Thr Thr Gly Arg Val Leu Asp
7055 7060 7065
Leu Pro Thr Tyr Ala Phe Gln His Gln Arg Tyr Trp Ala Ala Ser
7070 7075 7080
Thr Asp Arg Pro Ala Gly Asp Gly His Pro Leu Leu Asp Thr Val
7085 7090 7095
Val Ala Leu Pro Gly Ala Asp Gly Val Val Leu Thr Gly Arg Ile
7100 7105 7110
Ser Leu Ala Thr His Ala Trp Leu Ala Asp His Ala Val Arg Gly
7115 7120 7125
Thr Val Leu Leu Pro Gly Thr Gly Phe Val Glu Met Val Ala Arg
7130 7135 7140
Ala Ala Ala Glu Val Gly Cys Ala Val Val Asp Glu Leu Val Ile
7145 7150 7155
Glu Ala Pro Leu Leu Leu Pro Ala Ser Gly Gly Val Gln Leu Ser
7160 7165 7170
Val Ser Val Gly Glu Ala Asp Asp Ala Gly His Arg Pro Val Thr
7175 7180 7185
Val His Ser Gln Ala Asp Glu Thr Glu Ala Trp Val Arg His Val
7190 7195 7200
Thr Ala Thr Ile Ser Pro Ser Gly Pro Ile Val Ser Pro Pro Glu
7205 7210 7215
Phe Glu Val Trp Pro Pro Ala Gln Ala Glu Pro Val Glu Val Ala
7220 7225 7230
Arg Phe Tyr Asp Glu Leu Ala Ala Ala Gly Tyr Glu Tyr Gly Ala
7235 7240 7245
Ala Phe Gln Gly Leu Arg Ala Ala Trp Arg Ala Gly Glu Thr Ile
7250 7255 7260
Tyr Ala Glu Val Val Leu Ala Glu Asp Gln Thr Leu Glu Ala Ala
7265 7270 7275
Arg Phe Thr Val His Pro Ala Leu Leu Asp Ala Ala Leu Gln Ala
7280 7285 7290
Asn Ile Leu Asn Ala Ser Gly Asp Leu Arg Leu Pro Phe Ser Trp
7295 7300 7305
Gly Gln Val Gln Phe His Thr Thr Gly Ala Ala Thr Leu Arg Val
7310 7315 7320
Ala Val Thr Pro Val Ala Asp Gly Trp Thr Ile Gln Ala Thr Asp
7325 7330 7335
Asp Ala Gly Arg Pro Val Ala Thr Val Gly Ser Val Val Ala Arg
7340 7345 7350
Pro Val Ala Gly Leu Gly Ala Thr Ala Glu Asp Leu Phe Ala Leu
7355 7360 7365
Thr Trp Asn Glu Ile Pro Ala Pro Gly Gln Gly Gly Arg Thr Val
7370 7375 7380
Gly Arg Phe Glu Asp Leu Ala Asp Asp Gly Pro Val Pro Glu Leu
7385 7390 7395
Val Val Phe Thr Ala Leu Pro Asp Val Asp Ala Asp Pro Leu Val
7400 7405 7410
Arg Thr Arg Ala Leu Thr Ala Arg Val Leu Glu Ala Ile Gln Arg
7415 7420 7425
Trp Leu Gly Glu Pro Arg Phe Ala Asp Ser Thr Leu Val Val Arg
7430 7435 7440
Thr Gly Thr Asp Leu Ala Ser Ala Ala Val Ser Gly Leu Val Arg
7445 7450 7455
Ser Ala Gln Ser Glu His Pro Asp Arg Phe Ile Leu Val Glu Gly
7460 7465 7470
Asp Ser Ser Pro Val Glu Ile Gly Leu Asp Glu Pro Trp Leu Arg
7475 7480 7485
Val Asp Gly Gly Arg Tyr Glu Val Pro Arg Leu Ile Arg Leu Ser
7490 7495 7500
Ala Glu Pro Val Gln Glu Ala Ala Trp Asn Pro Asp Gly Met Val
7505 7510 7515
Leu Ile Thr Gly Gly Thr Gly Ala Leu Ala Gly Ile Leu Ala Arg
7520 7525 7530
His Leu Val Ala Glu Asn Lys Ala Arg Arg Leu Leu Leu Val Ser
7535 7540 7545
Arg Ser Val Pro Asp Asp Ala Leu Ile Ser Glu Leu Thr Glu Leu
7550 7555 7560
Gly Ala Glu Val Gly Thr Ala Val Cys Asp Val Ser Asp Arg Ala
7565 7570 7575
Ala Leu Ala Arg Val Leu Ala Gly Val Pro Ser Leu Thr Ala Val
7580 7585 7590
Ile His Thr Ala Gly Val Leu Asp Asp Gly Val Met Glu Ser Leu
7595 7600 7605
Thr Pro Gln Arg Leu Asp Thr Val Leu Arg Ala Lys Ala Asp Gly
7610 7615 7620
Ala Trp His Leu His Glu Leu Thr Arg Asp Arg Asp Leu Ala Ala
7625 7630 7635
Phe Val Met Tyr Ser Ser Ala Ala Gly Leu Met Gly Ser Pro Gly
7640 7645 7650
Gln Gly Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala Leu Ala
7655 7660 7665
Val Glu Arg Arg Ala Glu Gly Leu Pro Ala Leu Ser Leu Ala Trp
7670 7675 7680
Gly Phe Trp Glu Glu Thr Thr Gly Leu Thr Ala Asn Leu Thr Gly
7685 7690 7695
Ala Asp Arg Asp Arg Ile Arg Arg Gly Gly Leu Gln Thr Ile Thr
7700 7705 7710
Ala Glu Arg Gly Met Arg Met Phe Asp Thr Ala Thr Gln His Gly
7715 7720 7725
Glu Pro Val Leu Leu Ala Ala Pro Ile Ser Pro Val Arg Asp Gly
7730 7735 7740
Glu Val Pro Ala Leu Leu Arg Ser Leu His Arg Arg Gly Thr Arg
7745 7750 7755
Arg Gly Thr Thr Ala Asp Ala Ser Ala Gln Trp Leu Ala Gly Leu
7760 7765 7770
Ala Pro Glu Glu Arg Glu Gly Ala Leu Ile Lys Val Val Arg Asp
7775 7780 7785
Thr Ala Ala Val Val Leu Gly His Ala Asp Ala Gly Thr Ile Pro
7790 7795 7800
Val Thr Ala Ala Phe Lys Asp Leu Gly Leu Asp Ser Leu Thr Ala
7805 7810 7815
Val Glu Leu Arg Asn Ser Leu Ala Lys Ser Thr Gly Leu Arg Leu
7820 7825 7830
Pro Ala Thr Met Val Phe Asp Tyr Pro Thr Pro Ala Ser Leu Ala
7835 7840 7845
Ala Arg Leu Asp Asp Leu Met Asn Pro Arg Val Ser Ser Thr Ala
7850 7855 7860
Leu Leu Ala Glu Leu Asp Arg Ile Glu Gly Met Phe Asp Ser Val
7865 7870 7875
Thr Phe Asp Glu Lys Gln Ala Ser Leu Val Lys Asp Arg Leu Ser
7880 7885 7890
Ala Ala Leu Gly Lys Trp Gln Gln Ile Ser Arg Ser Ala Asp Val
7895 7900 7905
Ala Thr Val Ala Leu Ala Asn Ala Asp Ala Gly Glu Ile Leu Asp
7910 7915 7920
Phe Ile Asp Arg Glu Phe Gly Asn Pro Thr Ile
7925 7930
<210> 167
<211> 8134
<212> PRT
<213> Streptomyces violaceusniger
<400> 167
Met Pro Asp His Asp Lys Leu Val Glu Tyr Leu Arg Trp Ala Thr Ala
1 5 10 15
Glu Leu His Thr Thr Arg Ala Lys Leu Gln Ala Ala Thr Glu Ala Gly
20 25 30
Thr Gln Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly
35 40 45
Val Ser Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp
50 55 60
Ala Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Asp Gly Leu
65 70 75 80
Tyr Asp Pro Asp Pro Asp Val Pro Gly Lys Ser Tyr Thr Val Glu Gly
85 90 95
Gly Phe Leu Asp Ala Val Thr Gly Phe Asp Ala Pro Phe Phe Gly Ile
100 105 110
Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu Val Leu
115 120 125
Glu Ala Ser Trp Glu Ala Phe Glu Arg Ala Gly Ile Glu Pro Gly Ser
130 135 140
Val Arg Gly Ser Asp Thr Gly Val Phe Met Gly Ala Phe Pro Gly Gly
145 150 155 160
Tyr Gly Thr Gly Ala Asp Leu Gly Gly Phe Gly Met Thr Gly Gly Ala
165 170 175
Ala Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly
180 185 190
Pro Ala Met Thr Val Asp Thr Val Cys Ser Ser Ser Leu Val Ala Leu
195 200 205
His Gln Ala Gly Tyr Ala Leu Arg His Gly Glu Cys Ser Leu Ala Leu
210 215 220
Val Gly Gly Val Thr Val Met Ser Thr Pro Gln Thr Phe Val Glu Phe
225 230 235 240
Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala
245 250 255
Asp Asn Ala Asp Gly Thr Gly Trp Ser Glu Gly Val Gly Val Leu Leu
260 265 270
Val Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala
275 280 285
Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
290 295 300
Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala Leu
305 310 315 320
Ala Asn Ala Gly Leu Thr Gly Ala Asp Val Asp Val Val Glu Ala His
325 330 335
Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln Ala Val Ile
340 345 350
Ala Thr Tyr Gly Arg Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu
355 360 365
Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val
370 375 380
Ile Lys Met Val Met Ala Leu Gln Asn Gly Val Val Pro Arg Thr Leu
385 390 395 400
His Ile Glu Glu Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val
405 410 415
Gln Leu Val Thr Glu Asn Arg Pro Trp Pro Glu Leu Gly Arg Ala Arg
420 425 430
Arg Ala Ala Val Ser Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val
435 440 445
Ile Leu Glu Ser Ala Pro Asp Gln Pro Pro Ala Pro Thr Thr Asp Thr
450 455 460
Pro Val Ser Ala Val Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala
465 470 475 480
Lys Thr Val Pro Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Thr Tyr
485 490 495
Leu Thr Thr Thr Pro Asp Thr Asp Leu Pro Ala Val Ala Ser Thr Leu
500 505 510
Ala Thr Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu
515 520 525
Asp Thr Val Thr Gly Thr Ala Ile Pro Asp Pro Arg Val Val Phe Val
530 535 540
Phe Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu Leu
545 550 555 560
Thr Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala Ala Ala
565 570 575
Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu Asp Asp Pro
580 585 590
Ser Val Val Asp Arg Val Asp Val Val Gln Pro Ala Cys Trp Ala Val
595 600 605
Met Ile Ser Leu Ala Ala Val Trp Gln Ala Ala Gly Ile His Pro Asp
610 615 620
Ile Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Cys Leu Ala
625 630 635 640
Gly Ala Ile Ser Leu Pro Asp Ala Ala Arg Ile Val Ala Gln Arg Ser
645 650 655
Gln Leu Ile Ala His Gln Leu Thr Gly His Gly Ala Met Ala Ser Ile
660 665 670
Ser Leu Pro Ala Asp Asp Ile Pro Thr Thr Asp Lys Val Trp Ile Ala
675 680 685
Ala His Asn Gly Thr Ser Thr Val Ile Ala Gly Asp Pro Gln Ala Val
690 695 700
Glu Ala Val Leu Ala Thr Cys Glu Thr Arg Gly Ala Arg Val Arg Lys
705 710 715 720
Ile Asn Val Asp Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg
725 730 735
Thr Glu Leu Leu Asp Ile Thr Thr Gly Ile Glu Ala His Thr Pro Ala
740 745 750
Val Pro Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu
755 760 765
Asp Pro Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly
770 775 780
Pro Ala Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile Glu
785 790 795 800
Ile Ser Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala Ala Thr
805 810 815
Val Ala Thr Leu Arg Arg Asp Glu Asp Thr Thr Gln Arg Leu Leu Thr
820 825 830
Ala Phe Ala Glu Ala His Val His Gly Ala Thr Ile Asp Trp Pro Thr
835 840 845
Val Leu Asp Thr Thr Thr Thr Pro Val Leu Asp Leu Pro Thr Tyr Pro
850 855 860
Phe Gln Arg Gln Arg Tyr Trp Ala Thr Ser Asn Gly Arg Ser Thr Gly
865 870 875 880
Gln Gly His Pro Leu Leu Glu Thr Val Val Ala Leu Pro Gly Thr Asp
885 890 895
Gly Val Ala Leu Thr Gly Arg Ile Ser Leu Ala Thr His Pro Trp Leu
900 905 910
Thr Asp His Thr Val Arg Gly Thr Val Leu Leu Pro Gly Thr Ala Phe
915 920 925
Val Glu Leu Val Thr Arg Ala Ala Thr Glu Val Asn Cys Gln Ile Ile
930 935 940
Asp Glu Leu Ile Ile Glu Ala Pro Leu Pro Leu Pro Gln Thr Asp Gly
945 950 955 960
Val Gln Leu Ser Val Thr Val Gly Glu Ala Asp Glu Ala Gly His Arg
965 970 975
Pro Val Thr Val Tyr Ser Gln Thr Asp Glu Ser Asp Asp Trp Ile Gln
980 985 990
His Val Thr Ala Thr Ile Gly Pro Gly Ala Ser Leu Pro Glu Thr Ala
995 1000 1005
Ala Trp Pro Pro Ala His Ala Glu Pro Val Asn Val Thr Gly Leu
1010 1015 1020
Tyr Asp Asn Leu Ala Ala Ala Gly Tyr Glu Tyr Gly Pro Ala Phe
1025 1030 1035
Gln Gly Leu Gln Ala Ala Trp Arg Ala Gly Asp Thr Val Tyr Ala
1040 1045 1050
Glu Val Thr Leu Ala Glu Glu Gln Ala Gln Glu Thr Ala Arg Phe
1055 1060 1065
Thr Met His Pro Ala Leu Leu Asp Ala Ala Leu His Thr Ile Ala
1070 1075 1080
Leu His Asp Thr Gly Asp Leu His Leu Pro Phe Ser Trp Thr Arg
1085 1090 1095
Val Gln Phe His Gly Thr Gly Ala Ala Thr Leu Arg Val Ala Val
1100 1105 1110
Thr Pro Ala Ala Asp Gly Trp Asn Ile Arg Ala Thr Asp Asp Thr
1115 1120 1125
Gly Arg Ala Val Ala Thr Ile Gly Ser Leu Val Thr Arg Pro Met
1130 1135 1140
Ala Ala Glu Thr Thr Asp Asp Leu Leu Ala Leu Thr Trp Thr Glu
1145 1150 1155
Ile Pro Ala Pro Glu Pro Val Asp Pro Thr Asp Val Val Val Phe
1160 1165 1170
Thr Ala Leu Pro Asp Thr Val Glu Asp Val Pro Ala Gln Thr Arg
1175 1180 1185
Ala Leu Thr Thr Arg Val Leu His Thr Ile Gln Glu Trp Leu Ala
1190 1195 1200
Asp Asp Asp Arg Thr Leu Ile Val Arg Thr Gly Thr Asp Leu Ala
1205 1210 1215
Ser Ala Ala Val Ser Gly Leu Val Arg Ser Ala Gln Ser Glu His
1220 1225 1230
Pro Gly Arg Phe Ile Leu Val Glu Ser Ala Asp Glu Ala Leu Thr
1235 1240 1245
Gln Glu Gln Leu Ala Ala Thr Ala Gly Leu Asp Glu Pro Arg Leu
1250 1255 1260
Arg Ile Thr Gly Gly Arg Tyr Glu Val Pro Arg Leu Thr Arg Glu
1265 1270 1275
Asp Thr Ala Leu Ala Val Pro Thr Asp Arg Ala Trp Leu Leu Glu
1280 1285 1290
Gln Pro Arg Ser Gly Ser Leu Glu Asp Leu Ala Leu Leu Pro Thr
1295 1300 1305
Asp Ala Ala Glu Arg Pro Leu Gln Ala Gly Glu Val Arg Ile Gly
1310 1315 1320
Val Arg Ala Ala Gly Met Asn Phe Arg Asp Val Val Val Ala Leu
1325 1330 1335
Gly Met Val Thr Asp Thr Arg Leu Ala Gly Gly Glu Ala Ala Gly
1340 1345 1350
Val Val Leu Glu Val Gly Thr Asp Val Asn Asp Phe Arg Pro Gly
1355 1360 1365
Asp Arg Val Phe Gly Ile Leu Glu Gly Gly Phe Gly Ser Val Ala
1370 1375 1380
Ile Cys Asp His Arg Thr Leu Ala Val Ile Pro Asp Gly Trp Ser
1385 1390 1395
Phe Thr Thr Ala Ala Ser Val Pro Ile Ala Phe Ala Thr Ala Tyr
1400 1405 1410
Tyr Gly Leu Val Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser Val
1415 1420 1425
Leu Ile His Ala Ala Thr Gly Gly Val Gly Ile Ala Ala Thr Gln
1430 1435 1440
Ile Ala Arg His Leu Gly Ala Glu Ile Tyr Gly Thr Ala Ser Val
1445 1450 1455
Gly Lys Gln His Val Leu Arg Asp Ala Gly Leu Ala Asp Asp Arg
1460 1465 1470
Ile Ala Asp Ser Arg Thr Thr Asp Phe Arg Asp Thr Phe Arg Asp
1475 1480 1485
Gly Thr Gln Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Arg
1490 1495 1500
Gly Glu Phe Ile Asp Ala Ser Leu Asp Leu Leu Val Asp Gly Gly
1505 1510 1515
Arg Phe Ile Glu Met Gly Lys Thr Asp Ile Arg Asp Ala Ala Gln
1520 1525 1530
Ile Pro Asp Ala Thr Tyr His Ala Phe Asp Leu Met Asp Ala Gly
1535 1540 1545
His Asp Arg Leu Arg Glu Ile Met Thr Glu Leu Leu Ala Leu Phe
1550 1555 1560
Glu Gln Gly Val Leu His Pro Met Pro Val His Ala Phe Asp Ile
1565 1570 1575
Arg Gln Ala Arg Glu Ala Phe Ser Trp Met Ser Arg Ala Arg His
1580 1585 1590
Ile Gly Lys Leu Val Leu Thr Ile Pro Gln Pro Ile Asp Pro Asp
1595 1600 1605
Gly Thr Val Leu Ile Thr Gly Gly Ser Gly Val Leu Ala Gly Ile
1610 1615 1620
Val Ala Arg Tyr Leu Val Thr Glu Asn Arg Ala Arg His Leu Leu
1625 1630 1635
Leu Leu Ser Arg Ser Ala Pro Ser Ala Ser Leu Ile Asp Glu Leu
1640 1645 1650
Thr Ala Leu Gly Ala His Val Asp Val Ala Ala Cys Asp Val Ala
1655 1660 1665
Asp Arg Ala Ala Leu Ala Glu Ile Leu Asp Gly Val Asp Leu Thr
1670 1675 1680
Ala Val Ile His Thr Ala Gly Ala Leu Asp Asp Gly Val Val Glu
1685 1690 1695
Ser Leu Thr Pro Gln Arg Leu Asp Thr Val Leu Thr Pro Lys Ala
1700 1705 1710
Asp Gly Ala Trp His Leu His Glu Leu Thr Arg Asp Arg Asp Leu
1715 1720 1725
Ala Ala Phe Ile Val Tyr Ser Ser Ala Ala Gly Val Leu Gly Ala
1730 1735 1740
Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala
1745 1750 1755
Leu Ala Val His Arg Arg Leu Glu Gly Leu Pro Gly Leu Ser Leu
1760 1765 1770
Ala Trp Gly Leu Trp Glu Asp Ala Ser Gly Leu Thr Ala Asp Leu
1775 1780 1785
Thr Asp Ala Asp Arg Asp Arg Ile Arg Arg Ser Gly Gln Arg Ala
1790 1795 1800
Ile Thr Ala Ala Tyr Gly Met Arg Met Leu Asp Ala Ala Thr Arg
1805 1810 1815
Gln Ser Glu Ala Ile Leu Leu Ala Ala Pro Ile Ser Pro Ile Gln
1820 1825 1830
Asp Gly Asp Val Pro Ala Ile Leu Arg Ser Leu His Arg Arg Val
1835 1840 1845
Gly Arg Arg Ala Ser Val Ala His Gly His Pro Ala Asp Leu Thr
1850 1855 1860
Pro Glu Ala Leu Leu Lys Val Val Arg Asp Ser Ala Ala Met Val
1865 1870 1875
Leu Gly His Thr Asn Ala Asp Thr Val Pro Thr Ala Thr Ala Phe
1880 1885 1890
Gln Glu Leu Gly Leu Asp Ser Leu Thr Ala Val Glu Leu Arg Asn
1895 1900 1905
Ser Leu Thr Lys Ala Thr Gly Leu Arg Leu Pro Ala Thr Met Ala
1910 1915 1920
Phe Asp Tyr Pro Thr Pro Asp Ala Leu Ala Ala Arg Leu Gly Glu
1925 1930 1935
Leu Leu Ala Gly Glu Ala Ala Pro Lys Ala Ala Ala Ala Val Arg
1940 1945 1950
Arg Ala Thr Ala Ser Asp Glu Pro Leu Ala Ile Val Gly Met Ala
1955 1960 1965
Cys Arg Leu Pro Gly Gly Val Ser Ser Pro Glu Asp Leu Trp Arg
1970 1975 1980
Leu Val Glu Ser Gly Thr Asp Ala Ile Thr Asp Phe Pro Thr Asp
1985 1990 1995
Arg Gly Trp Asp Thr Asp Thr Leu Phe Asp Pro Asp Pro Asp Thr
2000 2005 2010
Pro Gly Lys Thr Tyr Thr Val His Gly Gly Phe Leu Asn Asp Val
2015 2020 2025
Ala Gly Phe Asp Ala Pro Phe Phe Gly Ile Ser Pro Arg Glu Ala
2030 2035 2040
Val Ala Met Asp Pro Gln Gln Arg Leu Val Leu Glu Ser Ser Trp
2045 2050 2055
Glu Ala Phe Glu Arg Ala Gly Ile Gln Pro Asp Ser Ile Arg Gly
2060 2065 2070
Ser Asp Thr Gly Val Phe Met Gly Ala Tyr Pro Asp Gly Tyr Gly
2075 2080 2085
Ile Gly Ala Asp Leu Ala Gly Phe Gly Val Thr Ala Gly Ala Gly
2090 2095 2100
Ser Val Leu Ser Gly Arg Val Ser Tyr Phe Phe Gly Leu Glu Gly
2105 2110 2115
Pro Ala Met Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala
2120 2125 2130
Leu His Gln Ala Ala Tyr Ala Leu Arg Gln Gly Glu Cys Ser Leu
2135 2140 2145
Ala Leu Val Gly Gly Val Thr Val Met Pro Ser Pro Arg Thr Phe
2150 2155 2160
Ile Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Ser
2165 2170 2175
Lys Ala Phe Ala Asp Ala Ala Asp Gly Thr Gly Phe Ser Glu Gly
2180 2185 2190
Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Gln Ala Lys
2195 2200 2205
Gly His Asn Ile Leu Ala Leu Val Arg Ser Ser Ala Val Asn Gln
2210 2215 2220
Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln
2225 2230 2235
Gln Arg Val Ile Gln Ser Ala Leu Ala Gly Ala Gly Leu Thr Ser
2240 2245 2250
Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly Thr Thr Leu
2255 2260 2265
Gly Asp Pro Ile Glu Ala Gln Ala Val Leu Ala Thr Tyr Gly Gln
2270 2275 2280
Asp Arg Asp Gln Pro Val Leu Leu Gly Ser Leu Lys Ser Asn Leu
2285 2290 2295
Gly His Thr Gln Ala Ala Ala Gly Val Ser Gly Val Ile Lys Met
2300 2305 2310
Val Met Ala Leu Gln His Asn Thr Val Pro Ala Thr Leu His Val
2315 2320 2325
Asp Ala Pro Ser Arg His Val Asp Trp Thr Ala Gly Ala Val Arg
2330 2335 2340
Leu Ala Thr Glu Asn Gln Pro Trp Pro Glu Thr Asn Arg Pro Arg
2345 2350 2355
Arg Ala Gly Val Ser Ser Phe Gly Val Ser Gly Thr Asn Ala His
2360 2365 2370
Val Ile Leu Glu Gln Ala Pro Ala Ala Ser Pro Val Glu Pro Val
2375 2380 2385
Asp Thr Thr Asp Val Val Ile Pro Leu Val Val Ser Ala Arg Ser
2390 2395 2400
Ser Gly Ser Leu Ser Asp Gln Ala Asp Arg Leu Ala Ala Leu Val
2405 2410 2415
Gly Ser Pro Asp Ala Pro Ala Leu Thr Ser Leu Ala Asp Ala Leu
2420 2425 2430
Leu Thr Arg Arg Thr Val Phe Ser Gln Arg Ala Val Val Val Ala
2435 2440 2445
Gly Ser His Glu Gln Ala Ala Ala Gly Leu Arg Ala Leu Ala Ser
2450 2455 2460
Gly Asp Ser His Pro Ala Leu Val Thr Gly Ala Ala Gly Pro Ala
2465 2470 2475
Arg Gly Val Val Leu Val Phe Pro Gly Gln Gly Ser Gln Trp Ala
2480 2485 2490
Gly Met Gly Ala Glu Leu Leu Asp Thr Ser Pro Val Phe Ala Ala
2495 2500 2505
Arg Ile Ala Glu Cys Ala Glu Ala Leu Arg Pro Trp Val Asp Trp
2510 2515 2520
Ser Leu Asp Glu Val Leu Arg Gly Asp Ala Ser Ala Asp Val Leu
2525 2530 2535
Gly Arg Val Asp Val Val Gln Pro Ala Ser Phe Ala Val Met Val
2540 2545 2550
Gly Leu Ala Ala Val Trp Glu Ser Ala Gly Val Arg Pro Asp Ala
2555 2560 2565
Val Leu Gly His Ser Gln Gly Glu Ile Ala Ala Ala Tyr Val Ala
2570 2575 2580
Gly Ala Leu Ser Leu Thr Asp Ala Ala Lys Ile Val Ala Val Arg
2585 2590 2595
Ser Arg Leu Ile Ala Ala Arg Leu Ala Gly Arg Gly Gly Met Ala
2600 2605 2610
Ser Val Ala Leu Ala Pro Asp Glu Ala Ala Ala Lys Leu Gly Arg
2615 2620 2625
Thr Glu Leu Ala Ala Val Asn Gly Pro Ala Ser Val Val Ile Ala
2630 2635 2640
Gly Asp Ala Glu Ala Leu Asp Glu Thr Leu Ala Met Leu Glu Gly
2645 2650 2655
Glu Ala Val Arg Val Arg Arg Val Ala Val Asp Tyr Ala Ser His
2660 2665 2670
Thr Pro His Val Glu Glu Leu Glu Gln Ser Met Ala Glu Ala Leu
2675 2680 2685
Ala Asp Val Arg Ser Arg Gln Pro Arg Val Gly Phe Leu Ser Thr
2690 2695 2700
Val Thr Gly Asp Trp Val Thr Glu Ala Gly Ala Leu Asp Gly Gly
2705 2710 2715
Tyr Trp Tyr Arg Asn Leu Arg Gln Pro Val Arg Phe Gly Pro Ala
2720 2725 2730
Val Ala Ser Leu Ala Glu Ala Gly Tyr Thr Val Phe Val Glu Ala
2735 2740 2745
Ser Ala His Pro Val Leu Val Gln Pro Val Ala Glu Thr Leu Asp
2750 2755 2760
Arg Thr Asp Ala Val Val Thr Gly Thr Leu Arg Arg Gln Asp Gly
2765 2770 2775
Gly Leu Pro Arg Leu Leu Thr Ser Met Ala Glu Leu Phe Val Gly
2780 2785 2790
Gly Val Pro Val Asn Trp Pro Val Leu Leu Pro Ala Gly Ala Val
2795 2800 2805
Arg Gly Trp Val Asp Leu Pro Thr Tyr Ala Phe Asp His Gln Arg
2810 2815 2820
Tyr Trp Leu Glu Asn Arg Val Ala Thr Asp Ala Ala Ala Leu Gly
2825 2830 2835
Leu Ala Gly Ala Asp His Pro Leu Leu Gly Ala Ile Val Ala Val
2840 2845 2850
Pro Gln Ser Gly Gly Val Ala Met Thr Ser Arg Leu Ser Pro Arg
2855 2860 2865
Asn His Pro Trp Leu Ala Glu His Thr Leu Gly Gly Val Pro Thr
2870 2875 2880
Val Pro Thr Ser Val Leu Val Glu Leu Ala Val Arg Ala Gly Asp
2885 2890 2895
Glu Val Gly Cys Gly Val Val Glu Glu Leu Thr Val Asp Ala Pro
2900 2905 2910
Leu Leu Leu Pro Glu Arg Gly Gly Val Arg Val Gln Val Ile Val
2915 2920 2925
Gly Ala Thr Asp Ala Asn Gly Gln Arg Gly Leu Asp Ile Phe Ser
2930 2935 2940
Ala Pro Glu Asp Thr Gly Gln Glu Ala Trp Thr Arg His Ala Thr
2945 2950 2955
Gly Thr Leu Ala Pro Gly Gly Asp Ile Ala Ala Asp Val Asp Leu
2960 2965 2970
Ser Ala Trp Pro Pro Ala Asn Ala Gln Pro Val Asp Val Thr Asp
2975 2980 2985
Gly Tyr Asp Leu Leu Glu Arg Ala Gly Tyr Gly Tyr Gly Pro Ala
2990 2995 3000
Phe Gln Gly Val Arg Ala Ile Trp Arg Arg Gly Glu Glu Leu Phe
3005 3010 3015
Ala Glu Val Ala Leu Glu Pro Glu Leu Thr Asp Thr Ala Ala Arg
3020 3025 3030
Phe Gly Leu His Pro Ala Leu Leu Asp Ala Ala Trp His Pro Glu
3035 3040 3045
Leu Arg Asp Glu Val Ala Glu Thr Ser Pro Asp Gly Arg Arg Trp
3050 3055 3060
Trp Ser Gln Pro Ser Arg Trp Ala Gly Leu Arg Leu His Thr Ala
3065 3070 3075
Gly Ala Thr Val Leu Arg Val Arg Leu Ala Pro Val Asp Ala Asp
3080 3085 3090
Ser Met Ser Leu Gln Ala Ala Asp Glu Thr Gly Asp Pro Val Leu
3095 3100 3105
Thr Val Asp Ser Leu Ser Leu Cys Ala Val Ser Ala Asp Gln Leu
3110 3115 3120
Thr Thr Ala Glu Ser Ser Asp Asp Ala Leu Phe Arg Leu Glu Trp
3125 3130 3135
Thr Pro Leu Ser Lys Ala Pro Thr Ala Ala Arg Ser Trp Val Pro
3140 3145 3150
Val Glu Thr Gly Ala Asp Val Ala Ala Leu Asp Gly Gln Ala Val
3155 3160 3165
Val Asp Ala Val Met Leu Glu Ala Ala Gly Thr Gly Asp Ala Leu
3170 3175 3180
Glu Leu Thr Cys Arg Val Leu Glu Val Val Gln Ala Trp Leu Thr
3185 3190 3195
Leu Pro Gly Trp Asp Glu Ser Arg Leu Val Val Val Thr Arg Gly
3200 3205 3210
Ala Val Gly Ala Val Gly Asp Pro Ala Gly Ser Ala Val Trp Gly
3215 3220 3225
Leu Val Arg Ala Ala Gln Ala Glu Asn Pro Asp Arg Ile Ala Leu
3230 3235 3240
Leu Asp Leu Asp Gly Gly Arg Pro Val Glu Pro Leu Leu Ala Glu
3245 3250 3255
Ser Glu Pro Gln Leu Ala Ile Arg Gly Ala Glu Ala Leu Val Pro
3260 3265 3270
Arg Leu Ile Arg Ala Ala Ala Ala Thr Asp Ala Pro Ala Leu Phe
3275 3280 3285
Asp Glu Ser Gln Thr Val Leu Ile Thr Gly Gly Thr Gly Ser Leu
3290 3295 3300
Gly Gly Leu Leu Ala Arg His Leu Val Gly Arg Tyr Gly Leu Arg
3305 3310 3315
Arg Leu Val Leu Val Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala
3320 3325 3330
Tyr Glu Leu Ala Ala Glu Leu Ala Ala His Gly Ala Glu Ala Ala
3335 3340 3345
Leu Val Ala Cys Asp Leu Thr Asp Arg Asp Ala Val Ala Arg Leu
3350 3355 3360
Leu Thr Glu His His Pro Thr Ala Val Val His Ala Ala Gly Val
3365 3370 3375
Ser Asp Asp Gly Val Ile Gly Thr Leu Thr Ser Asp Arg Leu Ala
3380 3385 3390
Tyr Val Phe Gly Pro Lys Ala Thr Ala Ala Arg His Leu Asp Glu
3395 3400 3405
Leu Thr Arg Glu Leu Leu Pro Asp Leu Ala Ala Phe Val Thr Tyr
3410 3415 3420
Ser Ser Ile Ser Ala Val Phe Leu Gly Ala Gly Ser Gly Gly Tyr
3425 3430 3435
Ala Ala Ala Asn Ala Tyr Leu Asp Gly Leu Met Ala Arg Arg His
3440 3445 3450
Ala Glu Gly Leu Pro Gly Leu Ser Leu Ala Trp Gly Leu Trp Asp
3455 3460 3465
Gln Glu Ala Asp Gly Gly Gly Met Ala Ala Gly Leu Gln Asp Ile
3470 3475 3480
Thr Arg Asn Arg Met Arg Arg Arg Gly Gly Val Leu Ser Phe Thr
3485 3490 3495
Pro Ala Glu Gly Met Ala Leu Phe Asp Ala Ala Met Ala Thr Asp
3500 3505 3510
Glu Ala Leu Val Val Pro Val Arg Leu Asp Leu Pro Ala Leu Arg
3515 3520 3525
Ala Glu Ala Val Ala Glu Gly Arg Ser Ala Pro Val Leu Leu Arg
3530 3535 3540
Gly Leu Val Arg Pro Gly Arg Arg Leu Ala Arg Thr Val Ser Gly
3545 3550 3555
Gly Thr Gly Val Leu Ala Asp Leu Thr Pro Glu Ala Leu Leu Lys
3560 3565 3570
Leu Val Arg Gly Arg Ala Ala Ala Val Leu Gly His Val Asp Ala
3575 3580 3585
Asp Ala Val Pro Val Ala Ala Ala Phe Lys Asp Leu Gly Val Asp
3590 3595 3600
Ser Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Ala Lys Ala Thr
3605 3610 3615
Gly Leu Arg Leu Pro Ala Thr Leu Val Phe Asp Tyr Pro Thr Pro
3620 3625 3630
Thr Val Leu Ala Gly Arg Leu Gly Glu Leu Leu Ala Gly Gly Thr
3635 3640 3645
Ala Pro Val Arg Ala Ala Val Val Arg Arg Ala Ala Ala Ser Asp
3650 3655 3660
Glu Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly
3665 3670 3675
Val Leu Ser Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Gly
3680 3685 3690
Asp Ala Ile Ser Gly Phe Pro Val Asp Arg Gly Trp Asp Val Glu
3695 3700 3705
Asn Leu Phe Asp Pro Asp Pro Asp Ala Ala Gly Arg Thr Tyr Ala
3710 3715 3720
Val Arg Gly Gly Phe Leu Asp Gly Ala Ala Gly Phe Asp Ala Ser
3725 3730 3735
Phe Phe Gly Ile Ser Pro Arg Glu Ala Gln Ala Met Asp Pro Gln
3740 3745 3750
Gln Arg Leu Val Leu Glu Val Ser Trp Glu Ala Phe Glu Arg Ala
3755 3760 3765
Gly Ile Glu Pro Gly Ser Val Arg Gly Ser Asp Thr Gly Val Phe
3770 3775 3780
Met Gly Ala Tyr Pro Gly Gly Tyr Gly Met Gly Thr Asp Leu Gly
3785 3790 3795
Gly Phe Gly Met Thr Ser Val Ala Val Ser Val Leu Ala Gly Arg
3800 3805 3810
Val Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met Thr Val Asp
3815 3820 3825
Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Ser
3830 3835 3840
Ala Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val
3845 3850 3855
Thr Val Met Pro Thr Pro Gln Thr Phe Val Glu Phe Ser Arg Gln
3860 3865 3870
Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Ala
3875 3880 3885
Ala Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val
3890 3895 3900
Glu Arg Leu Ser Asp Ala Gln Ala Arg Gly His Asn Ile Leu Ala
3905 3910 3915
Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly
3920 3925 3930
Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Arg Val Ile Gln Ser
3935 3940 3945
Ala Leu Ala Gly Ala Gly Leu Ala Ser Ala Asp Val Asp Val Val
3950 3955 3960
Glu Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala
3965 3970 3975
Gln Ala Val Ile Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val
3980 3985 3990
Leu Leu Gly Ser Leu Lys Ser Asn Leu Gly His Thr Gln Ala Ala
3995 4000 4005
Ala Gly Val Ser Gly Val Ile Lys Met Val Met Ala Leu Gln Asn
4010 4015 4020
Gly Val Val Pro Arg Thr Leu His Ile Asp Glu Pro Ser Arg His
4025 4030 4035
Ile Asp Trp Thr Ala Gly Ala Val Glu Leu Val Thr Glu Asn Gln
4040 4045 4050
Ser Trp Pro Glu Thr Gly Arg Ala Arg Arg Ala Ala Val Ser Ser
4055 4060 4065
Phe Gly Ile Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala
4070 4075 4080
Pro Ala Gln Pro Val Pro Leu Val Asp Thr Pro Val Ser Asp Val
4085 4090 4095
Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Arg Thr Val Pro
4100 4105 4110
Ala Leu Ala Asp Leu Glu Asp Gln Leu Arg Ala Tyr Leu Thr Thr
4115 4120 4125
Ala Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Met
4130 4135 4140
Thr Arg Ser Val Phe Glu His Arg Ala Val Leu Leu Gly Glu Glu
4145 4150 4155
Thr Val Thr Gly Ile Ala Val Ser Asp Pro Arg Val Val Phe Val
4160 4165 4170
Phe Ser Gly Gln Gly Ser Gln Arg Val Gly Met Gly Glu Glu Leu
4175 4180 4185
Ala Ala Ala Phe Pro Leu Phe Ala Arg Leu His Arg Gln Val Trp
4190 4195 4200
Asp Leu Leu Asp Val Pro Asp Leu Glu Val Asp Asp Thr Gly Tyr
4205 4210 4215
Val Gln Pro Ala Leu Phe Ala Leu Gln Val Ala Leu Phe Gly Leu
4220 4225 4230
Leu Glu Ser Trp Gly Val Arg Pro Arg Ala Val Ile Gly His Ser
4235 4240 4245
Val Gly Glu Val Ala Ala Gly Tyr Val Ala Gly Val Trp Ser Leu
4250 4255 4260
Glu Asp Ala Cys Thr Leu Val Ser Ala Arg Ala Arg Leu Met Gln
4265 4270 4275
Ala Leu Pro Ala Gly Gly Ala Met Val Ala Val Pro Val Ser Glu
4280 4285 4290
Glu Arg Ala Arg Ala Val Leu Val Asp Gly Val Glu Ile Ala Ala
4295 4300 4305
Val Asn Gly Pro Ala Ser Val Val Leu Ser Gly Asp Glu Ser Ala
4310 4315 4320
Val Leu Arg Val Ala Glu Gly Leu Gly Arg Trp Thr Arg Leu Ser
4325 4330 4335
Ala Ser His Ala Phe His Ser Val Arg Met Glu Pro Met Leu Glu
4340 4345 4350
Glu Phe Arg Gln Val Ala Ser Glu Leu Thr Tyr Arg Glu Pro Arg
4355 4360 4365
Ile Val Met Ala Ala Gly Glu Gln Val Thr Thr Pro Glu Tyr Trp
4370 4375 4380
Val Arg Gln Val Arg Asp Thr Val Arg Phe Gly Asp Gln Val Ala
4385 4390 4395
Ala Phe Gly Asp Ala Val Phe Leu Glu Ile Gly Pro Asp Arg Thr
4400 4405 4410
Leu Ser Arg Leu Ile Asp Gly Ile Ala Met Leu Asp Gly Asp Asp
4415 4420 4425
Glu Val Arg Ala Ala Val Ala Ala Leu Ala Met Met His Val Gln
4430 4435 4440
Gly Val Gly Val Asp Trp Pro Ala Val Leu Gly Thr Thr Thr Gly
4445 4450 4455
Arg Val Leu Asp Leu Pro Thr Tyr Ala Phe Gln His Glu Arg Tyr
4460 4465 4470
Trp Met Val Ser Thr Gly Arg Pro Gly Gly Glu Gly His Pro Leu
4475 4480 4485
Leu Gly Trp Gly Val Pro Val Ala Glu Ala Asp Gly Arg Leu Tyr
4490 4495 4500
Thr Gly Arg Val Ala Arg Gln Asp Gly Pro Val Leu Pro Val Ala
4505 4510 4515
Ala Phe Val Glu Met Ala Phe Ala Ala Ala Gly Gly Arg Pro Ile
4520 4525 4530
Arg Glu Leu Ser Val Asp Ala Leu Leu Tyr Ile Pro Asp Asp Gly
4535 4540 4545
Thr Ala Glu Leu Gln Thr Trp Val Ser Glu His Arg Leu Thr Ile
4550 4555 4560
His Ala Arg Tyr Arg Asp Thr Glu Pro Trp Thr Arg Leu Ala Thr
4565 4570 4575
Ala Thr Leu Asp Thr Thr Glu Pro Ala Thr Thr His Thr Pro His
4580 4585 4590
Pro Gly Leu Ile Thr Thr Ala Leu Thr Leu Thr Gly Asp Glu Ala
4595 4600 4605
Pro Ala Ile Trp His Asp Leu Thr Leu His Thr Ser Asn Ala Thr
4610 4615 4620
Glu Leu His Thr His Ile Thr Pro Gly Asp Asp Gly Thr Leu Thr
4625 4630 4635
Ile Thr Ala Thr Asp Ala Thr Gly Gln Pro Val Leu Thr Ala His
4640 4645 4650
Ala Ala Thr Pro Thr Thr Ile Pro Val His Thr Pro Thr Thr Pro
4655 4660 4665
Ala Asp Asp Leu Leu Thr Leu Thr Trp Thr Gln Ile Pro Thr Pro
4670 4675 4680
Gly Pro Gly Asp Gly Ala Asp Ile Ala Val Cys Thr Ala Leu Pro
4685 4690 4695
Asp Pro Asp Ser Asp Pro Leu Ala Gln Thr Arg Thr Leu Thr Ala
4700 4705 4710
Gln Val Leu His Ser Ile Gln Ala Ser Leu Thr Gly Glu Asp Arg
4715 4720 4725
Pro Leu Val Val His Thr Gly Thr Gly Leu Ala Ser Ala Ala Val
4730 4735 4740
Ser Gly Leu Val Arg Ser Ala Gln Ser Glu His Pro Asp Arg Phe
4745 4750 4755
Ile Leu Val Glu Ser Asp Glu Thr Leu Thr Pro Asp Gln Leu Ala
4760 4765 4770
Ala Val Ala Gly Leu Asp Glu Pro Trp Leu Arg Ile Thr Asp Gly
4775 4780 4785
Arg Tyr Glu Val Pro Arg Leu Thr Lys Thr Thr Thr Thr Ala Thr
4790 4795 4800
Ala Thr Ala Val Ser Glu Pro Val Trp Asp Pro Asp Gly Thr Val
4805 4810 4815
Leu Ile Thr Gly Gly Ser Gly Ala Leu Ala Gly Ile Leu Ala Arg
4820 4825 4830
His Leu Val Thr Glu Arg Gly Val Arg His Leu Leu Leu Val Ser
4835 4840 4845
Arg Ser Thr Pro Ser Thr Thr Leu Ile Asp Glu Leu Arg Glu Leu
4850 4855 4860
Gly Ala His Val Asp Val Ala Ala Cys Asp Val Ser Asp Arg Ala
4865 4870 4875
Ala Leu Ala Arg Val Leu Asp Gly Val Asp Leu Thr Ala Val Phe
4880 4885 4890
His Thr Ala Gly Ala Leu Asp Asp Gly Val Val Glu Ser Leu Thr
4895 4900 4905
Pro Gln Arg Val Asp Ala Val Leu Arg Pro Lys Ala Asp Gly Ala
4910 4915 4920
Trp His Leu His Glu Leu Thr Arg Asp Arg Asp Leu Thr Ala Phe
4925 4930 4935
Val Met Tyr Ser Ser Ala Ala Gly Val Met Gly Ala Ala Gly Gln
4940 4945 4950
Gly Asn Tyr Ala Ala Ala Asn Ala Phe Leu Asp Ala Leu Ala Glu
4955 4960 4965
His Arg Arg Ala Asp Gly Leu Pro Ala Leu Ser Leu Ala Trp Gly
4970 4975 4980
Met Trp Asp Asp Ala Asp Gly Met Thr Ala Ser Leu Ser Gly Thr
4985 4990 4995
Asp His Arg Arg Ile Arg Arg Ser Gly Gln Arg Ala Ile Thr Ala
5000 5005 5010
Glu His Gly Met Arg Leu Leu Asp Lys Ala Ser Gly Arg Ser Glu
5015 5020 5025
Pro Val Leu Val Ala Thr Ala Met Asn Pro Ile Pro Asp Thr Asp
5030 5035 5040
Leu Pro Ala Leu Leu Arg Ser Leu Tyr Pro Lys Thr Ala Arg Lys
5045 5050 5055
Ser Gln Pro Ile Gln Glu Leu Ser Pro Glu Ala Leu Leu Lys Ile
5060 5065 5070
Val Arg Asp Ser Ala Ala Met Val Leu Gly His Ala Asn Ala Asp
5075 5080 5085
Thr Val Pro Thr Ala Thr Ala Leu Gln Glu Leu Gly Leu Asp Ser
5090 5095 5100
Leu Thr Ala Val Glu Leu Arg Asn Ser Leu Thr Lys Ala Thr Gly
5105 5110 5115
Leu Arg Leu Pro Ala Thr Met Ala Phe Asp Tyr Pro Thr Pro Ala
5120 5125 5130
Ala Leu Ala Gly Arg Leu Gly Glu Leu Leu Ala Gly Asp Thr Thr
5135 5140 5145
Pro Ala Thr Ala Ala Val Val Arg Arg Ala Thr Ala Ser Asp Glu
5150 5155 5160
Pro Leu Ala Ile Val Gly Met Ala Cys Arg Leu Pro Gly Gly Val
5165 5170 5175
Ser Thr Pro Glu Asp Leu Trp Arg Leu Val Glu Ser Gly Thr Asp
5180 5185 5190
Ala Ile Thr Asp Phe Pro Thr Asp Arg Gly Trp Asp Thr Asp Asp
5195 5200 5205
Leu Phe Asp Pro Asp Pro Asp Thr Pro Gly Lys Thr Tyr Thr Val
5210 5215 5220
His Gly Gly Phe Leu Asp Asp Val Ala Gly Phe Asp Ala Ser Phe
5225 5230 5235
Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Ser Gln Gln
5240 5245 5250
Arg Leu Val Leu Glu Ala Ala Trp Glu Ala Phe Glu Arg Ala Gly
5255 5260 5265
Ile Glu Pro Gly Ser Val Arg Gly Ser Asp Thr Gly Val Phe Met
5270 5275 5280
Gly Ala Tyr Pro Asp Gly Tyr Gly Ile Gly Ala Asp Leu Gly Gly
5285 5290 5295
Phe Gly Ala Thr Ala Gly Ala Gly Ser Val Leu Ser Gly Arg Leu
5300 5305 5310
Ser Tyr Phe Phe Gly Leu Glu Gly Pro Ala Met Thr Val Asp Thr
5315 5320 5325
Ala Cys Ser Ser Ser Leu Val Ala Leu His Gln Ala Gly Ser Ala
5330 5335 5340
Leu Arg Gln Gly Glu Cys Ser Leu Ala Leu Val Gly Gly Val Thr
5345 5350 5355
Val Ile Ala Asn Pro Gln Ile Phe Val Glu Phe Ser Arg Gln Arg
5360 5365 5370
Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Asn Ala
5375 5380 5385
Asp Gly Thr Gly Phe Ser Glu Gly Val Gly Val Leu Leu Val Glu
5390 5395 5400
Arg Leu Ser Asp Ala Gln Ala Lys Gly His Asn Ile Leu Ala Leu
5405 5410 5415
Val Arg Ser Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu
5420 5425 5430
Thr Ala Pro Asn Gly Pro Ser Gln Gln Arg Val Ile Arg Gln Ala
5435 5440 5445
Leu Ala Asn Ala Gly Leu Thr Gly Ala Glu Val Asp Val Val Glu
5450 5455 5460
Ala His Gly Thr Gly Thr Thr Leu Gly Asp Pro Ile Glu Ala Gln
5465 5470 5475
Ala Val Leu Ala Thr Tyr Gly Gln Asp Arg Asp Gln Pro Val Leu
5480 5485 5490
Leu Gly Ser Leu Lys Ser Asn Leu Gly His Thr Gln Ala Ala Ala
5495 5500 5505
Gly Val Ser Gly Val Ile Lys Met Val Met Ala Leu Arg His Asp
5510 5515 5520
Thr Val Pro Ala Thr Leu His Ile Asp Glu Pro Ser Arg His Ile
5525 5530 5535
Asp Trp Thr Ala Gly Ala Val Glu Leu Val Thr Glu Asn Gln Pro
5540 5545 5550
Trp Pro Val Leu Gly Arg Pro Arg Arg Ala Ala Val Ser Ala Phe
5555 5560 5565
Gly Val Ser Gly Thr Asn Ala His Val Ile Leu Glu Ser Ala Pro
5570 5575 5580
Asp Gln Pro Pro Ala Pro Ala Thr Asp Thr Pro Ala Pro Ala Ala
5585 5590 5595
Thr Ala Gly Val Val Pro Leu Pro Ile Ser Ala Lys Thr Val Pro
5600 5605 5610
Ala Leu Ala Asp Leu Glu Asp Arg Leu Arg Thr Tyr Leu Thr Thr
5615 5620 5625
Thr Pro Glu Thr Asp Leu Pro Ala Val Ala Ser Thr Leu Ala Thr
5630 5635 5640
Thr Arg Ser Leu Phe Glu His Arg Ala Val Leu Leu Gly Glu Asp
5645 5650 5655
Thr Val Thr Gly Thr Thr Ile Pro Asp Pro Arg Ile Val Phe Val
5660 5665 5670
Phe Pro Gly Gln Gly Trp Gln Trp Gln Gly Met Gly Ser Ala Leu
5675 5680 5685
Leu Thr Ser Ser Thr Val Phe Ala Glu Arg Met Ala Glu Cys Ala
5690 5695 5700
Ala Ala Leu Ser Glu Phe Val Asp Trp Asp Leu Leu Thr Val Leu
5705 5710 5715
Asp Asp Pro Ser Ile Val Asp Arg Val Asp Val Val Gln Pro Ala
5720 5725 5730
Cys Trp Ala Val Met Ile Ser Leu Ala Ala Val Trp Gln Ala Ala
5735 5740 5745
Gly Ile His Pro Asp Ile Val Leu Gly His Ser Gln Gly Glu Ile
5750 5755 5760
Ala Ala Ala Cys Leu Ala Gly Ala Ile Ser Leu Pro Asp Ala Ala
5765 5770 5775
Arg Ile Val Ala Gln Arg Ser Gln Leu Ile Ala His Gln Leu Thr
5780 5785 5790
Gly His Gly Ala Met Ala Ser Ile Ser Leu Pro Ala Asp Asp Ile
5795 5800 5805
Pro Thr Thr Asp Lys Val Trp Ile Ala Ala His Asn Gly Thr Ser
5810 5815 5820
Thr Val Ile Ala Gly Asp Pro Gln Ala Leu Asp Thr Val Leu Ala
5825 5830 5835
Thr Cys Glu Thr His Gly Ala Arg Val Arg Lys Ile Asn Val Asp
5840 5845 5850
Tyr Ala Ser His Thr Pro His Val Glu Gln Ile Arg Thr Glu Leu
5855 5860 5865
Leu Asp Ile Thr Thr Asp Ile Glu Ala His Thr Pro Thr Val Pro
5870 5875 5880
Trp Leu Ser Thr Thr Asp Asn Thr Trp Ile Asp Gln Pro Leu Asp
5885 5890 5895
Pro Thr Tyr Trp Tyr Arg Asn Leu Arg Glu Pro Val Arg Phe Gly
5900 5905 5910
Pro Ala Ile Asp Leu Leu Gln Thr Gln Asp Asn Asn Leu Phe Ile
5915 5920 5925
Glu Ile Ser Ala Ser Pro Val Leu Leu Gln Thr Met Asp Asn Ala
5930 5935 5940
Thr Thr Val Ala Thr Leu Arg Arg Asp Glu Asp Thr Thr Gln Arg
5945 5950 5955
Leu Leu Thr Ala Phe Ala Glu Ala His Val His Gly Ala Thr Ile
5960 5965 5970
Asp Trp Pro Thr Val Leu Asp Thr Thr Thr Thr Pro Val Leu Asp
5975 5980 5985
Leu Pro Thr Tyr Pro Phe Gln Arg Gln Arg Tyr Trp Ala Thr Ser
5990 5995 6000
Asn Gly Arg Pro Thr Ser Gln Gly His Pro Leu Leu Glu Thr Val
6005 6010 6015
Val Ala Leu Pro Gly Thr His Gly Val Ala Leu Thr Gly Arg Ile
6020 6025 6030
Ser Leu Ala Thr His Pro Trp Leu Thr Asp His Thr Val Arg Gly
6035 6040 6045
Thr Val Leu Leu Pro Gly Thr Ala Phe Val Glu Leu Val Thr His
6050 6055 6060
Ala Ala Thr Glu Val Asn Cys Gln Val Ile Asp Glu Leu Ile Ile
6065 6070 6075
Glu Ala Pro Leu Pro Leu Pro Gln Asn Gly Gly Val Gln Leu Ser
6080 6085 6090
Val Thr Val Gly Glu Ala Asp Glu Ala Gly His Arg Pro Val Thr
6095 6100 6105
Val Tyr Ser Gln Thr Asp Glu Ser Asp Asp Trp Val Gln His Val
6110 6115 6120
Thr Ala Thr Ile Ala Pro Gly Val Ser Ser Ser Glu Ser Ala Ala
6125 6130 6135
Trp Pro Pro Ala Gln Ala Glu Pro Val Asn Val Thr Gly Leu Tyr
6140 6145 6150
Asp Asn Leu Ala Ala Ala Gly Tyr Glu Tyr Gly Pro Ala Phe Gln
6155 6160 6165
Gly Leu Gln Thr Ala Trp Arg Asp Gly Ser Thr Val Tyr Ala Glu
6170 6175 6180
Val Thr Leu Ala Glu Glu Gln Ala Gln Glu Thr Ala Arg Phe Thr
6185 6190 6195
Met His Pro Ala Leu Leu Asp Ala Ala Leu His Thr Ile Ala Leu
6200 6205 6210
His Asp Thr Ala Asp Leu Gln Leu Pro Phe Ser Trp Arg Gln Val
6215 6220 6225
Gln Phe His Gly Ser Gly Ala Ala Thr Leu Arg Val Ala Val Thr
6230 6235 6240
Pro Ala Ala Asp Gly Trp Asn Ile Arg Ala Thr Asp Asp Thr Gly
6245 6250 6255
Gln Thr Val Ala Thr Ile Gly Ser Leu Val Thr Arg Pro Met Ala
6260 6265 6270
Ala Glu Thr Thr Asn Asp Leu Leu Ala Leu Thr Trp Thr Glu Ile
6275 6280 6285
Pro Ala Pro Glu Pro Val Asp Pro Ala Asp Val Val Val Phe Thr
6290 6295 6300
Ala Leu Pro Glu Pro Gly Ser Asp Pro Leu Ala Gln Thr Arg Ala
6305 6310 6315
Leu Thr Thr Arg Val Leu His Thr Ile Gln Glu Trp Leu Ala Asp
6320 6325 6330
Asp Asp Arg Thr Leu Ile Val Arg Thr Gly Thr Asp Leu Ala Ser
6335 6340 6345
Ala Ala Val Ser Gly Leu Val Arg Ser Ala Gln Ser Glu His Pro
6350 6355 6360
Gly Arg Phe Ile Leu Val Glu Ser Asp Asp Glu Thr Leu Thr His
6365 6370 6375
Glu Gln Leu Ala Ala Thr Ala Gly Leu Asp Glu Pro Arg Leu Arg
6380 6385 6390
Ile Thr Asp Gly Arg Tyr Glu Val Pro Arg Leu Thr Arg Glu Asp
6395 6400 6405
Thr Ala Leu Ala Val Pro Glu Gly Gly Ala Trp Met Leu Asp Gln
6410 6415 6420
Pro Ser Arg Ser Gly Thr Leu Gln Asp Leu Arg Leu Val Pro Thr
6425 6430 6435
Asp Ala Ala Glu Arg Pro Leu Arg Pro Gly Glu Val Arg Val Gly
6440 6445 6450
Val Arg Ala Ala Gly Leu Asn Phe Arg Asp Val Ala Val Ala Leu
6455 6460 6465
Gly Met Val Thr Asp Thr Arg Leu Ile Gly Gly Glu Gly Ala Gly
6470 6475 6480
Val Val Leu Glu Ala Gly Pro Gly Val Glu Asp Leu Arg Pro Gly
6485 6490 6495
Asp Arg Val Phe Gly Leu Leu Glu Gly Gly Phe Gly Pro Val Ala
6500 6505 6510
Val Ala Asp Arg Arg Ala Leu Ala Leu Ile Pro Asp Gly Trp Ser
6515 6520 6525
Phe Thr Thr Ala Ala Ser Val Pro Ile Ala Phe Ala Thr Ala Tyr
6530 6535 6540
Tyr Gly Leu Leu Asp Leu Ala Gly Leu Arg Ala Gly Glu Ser Val
6545 6550 6555
Leu Ile His Ala Ala Thr Gly Gly Val Gly Met Ala Ala Thr Gln
6560 6565 6570
Ile Ala Arg His Leu Gly Ala Asp Val Tyr Ala Thr Ala Ser Thr
6575 6580 6585
Gly Lys Gln His Val Leu Arg Asp Ala Gly Leu Ser Asp Asp Arg
6590 6595 6600
Ile Ala Asp Ser Arg Thr Thr Gly Phe Arg Glu Thr Phe Arg Asp
6605 6610 6615
Ser Thr Asp Gly Arg Gly Val Asp Val Val Leu Asn Ser Leu Lys
6620 6625 6630
Gly Asp Phe Val Asp Ala Ser Leu Asp Leu Leu Val Asp Gly Gly
6635 6640 6645
Arg Phe Ile Glu Met Gly Lys Thr Asp Ile Arg Asp Ala Ala Gln
6650 6655 6660
Ile Pro Asp Ala Thr Tyr Arg Ala Phe Asp Leu Met Asp Ala Gly
6665 6670 6675
Pro Glu Arg Leu Arg Glu Ile Ile Thr Glu Leu Leu Ala Leu Phe
6680 6685 6690
Glu Gln Gly Val Leu Arg Pro Leu Pro Val His Ala Phe Asp Ile
6695 6700 6705
Arg Gln Ala Arg Asp Ala Phe Gly Trp Met Ser Arg Ala Arg His
6710 6715 6720
Ile Gly Lys Leu Val Leu Thr Ile Pro Gln Pro Ile Asp Pro Asp
6725 6730 6735
Gly Thr Val Leu Ile Thr Gly Gly Ser Gly Val Leu Ala Gly Ile
6740 6745 6750
Val Ala Arg His Leu Val Ile Ala Glu Gly Leu Arg Asn Leu Leu
6755 6760 6765
Leu Leu Ser Arg Ser Ala Pro Ser Glu Ala Leu Ile Gly Glu Leu
6770 6775 6780
Thr Ala Leu Gly Ala Gln Val Glu Thr Ala Ala Cys Asp Ile Ala
6785 6790 6795
Asp Arg Ala Ala Leu Ala Arg Val Leu Asp Gly Val Pro Leu Thr
6800 6805 6810
Ala Val Ile His Thr Ala Gly Ala Leu Asp Asp Gly Val Val Glu
6815 6820 6825
Ser Leu Asp Pro Gln Arg Leu Asp Ser Val Leu Thr Pro Lys Ala
6830 6835 6840
Asp Gly Ala Trp His Leu His Glu Leu Thr Arg Asp Arg Asp Leu
6845 6850 6855
Ala Ala Phe Ile Met Tyr Ser Ser Ala Ala Gly Val Leu Gly Ala
6860 6865 6870
Ala Gly Gln Gly Asn Tyr Ala Ala Ala Asn Ala Phe Val Asp Ala
6875 6880 6885
Leu Ala Val His Arg Arg Phe Met Gly Leu Pro Ala Leu Ser Leu
6890 6895 6900
Ala Trp Gly Leu Trp Asp Asp Thr Ser Ala Leu Thr Ala Gly Leu
6905 6910 6915
Thr Asp Ser Asp His Asp Arg Ile Arg Arg Ser Gly Ala Arg Thr
6920 6925 6930
Ile Thr Ala Glu His Gly Met Arg Met Phe Asp Ala Ala Thr Arg
6935 6940 6945
Gln Ser Glu Ala Val Leu Leu Ala Ala Pro Met Gly Pro Ile Arg
6950 6955 6960
Gly Glu Asp Val Pro Ala Leu Leu Arg Gly Leu Ala Thr Val Arg
6965 6970 6975
Gln Pro Arg Thr Arg Ala Lys Arg Asp Met Gly Pro Glu Arg Leu
6980 6985 6990
Arg Asp Arg Leu Asn Gly Arg Thr Ser Val Glu Gln His Arg Ile
6995 7000 7005
Met Val Glu Leu Val Leu Ala His Ala Thr Ser Val Leu Gly His
7010 7015 7020
Glu Ser Pro Asp Ala Ile Ala Pro Asp Arg Ala Phe Lys Asp Leu
7025 7030 7035
Gly Met Asp Ser Leu Thr Ala Ile Glu Leu Arg Asn His Leu Val
7040 7045 7050
Ala Glu Thr Gly Val Arg Leu Pro Ala Thr Thr Ala Phe Asp His
7055 7060 7065
Pro Thr Ala Asp Asp Leu Ala Lys Arg Leu Leu Ala Glu Val Gly
7070 7075 7080
Leu Thr Pro Ala Pro Gln Arg Thr Glu Ala Asp Ile Arg Glu Glu
7085 7090 7095
Val Val Val Arg Glu Pro Ala Gly Asp Asp Ser Trp Thr Ser Glu
7100 7105 7110
Pro Ile Ala Ile Val Ser Met Ser Cys Arg Ala Pro Gly Gly Val
7115 7120 7125
Asp Ser Pro Glu Ser Leu Trp Arg Leu Val Glu Ser Gly Thr Asp
7130 7135 7140
Ala Ile Thr Asp Phe Pro Gly Asp Arg Gly Trp Asp Val Ala Gly
7145 7150 7155
Leu Tyr Ser Pro Asp Pro Asp Thr Gly Tyr Lys Thr Tyr Cys Val
7160 7165 7170
Gln Gly Gly Phe Leu Asp Ala Ala Ala Asp Phe Asp Ala Ala Phe
7175 7180 7185
Phe Gly Ile Ser Pro Arg Glu Ala Leu Gly Met Asp Pro Gln Gln
7190 7195 7200
Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Ile Glu Arg Ala Arg
7205 7210 7215
Ile Asp Pro Arg Ser Leu Arg Gly Arg Asn Val Gly Val Tyr Val
7220 7225 7230
Gly Gly Ala Ala Gln Gly Tyr Gly Val Gly Ala Ile Asp Gln Gln
7235 7240 7245
Arg Asp Asn Val Ile Thr Gly Ser Ser Ile Ser Leu Leu Ser Gly
7250 7255 7260
Arg Leu Ser Tyr Ala Leu Gly Leu Glu Gly Pro Gly Val Thr Val
7265 7270 7275
Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Cys
7280 7285 7290
Gln Ala Leu Arg Gln Arg Glu Cys Ser Met Ala Leu Val Ser Gly
7295 7300 7305
Val Ser Val Ile Pro Thr Pro Asp Val Phe Val Glu Phe Ser Arg
7310 7315 7320
Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ser Phe Ser Ala
7325 7330 7335
Ser Ala Asp Gly Thr Ile Trp Ala Glu Gly Val Gly Val Leu Val
7340 7345 7350
Leu Glu Arg Leu Ser Glu Ala Thr Arg Leu Gly His Arg Val Leu
7355 7360 7365
Ala Val Val Arg Gly Ser Ala Val Asn Ser Asp Gly Ala Ser Asn
7370 7375 7380
Gly Leu Thr Ala Pro Asn Gly Val Ser Gln Gln Arg Val Ile Arg
7385 7390 7395
Gln Ala Leu Thr Gly Ala Gly Leu Thr Ala Ala Asp Val Asp Val
7400 7405 7410
Val Glu Ala His Gly Thr Gly Thr Lys Leu Gly Asp Pro Ile Glu
7415 7420 7425
Ala Glu Ala Ile Leu Ala Thr Tyr Gly Gln Asp Arg Ser Thr Pro
7430 7435 7440
Val Cys Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Met Ala
7445 7450 7455
Ala Ser Gly Val Leu Ala Val Ile Lys Met Val Glu Ala Met Arg
7460 7465 7470
His Gly Leu Ile Pro Arg Thr Leu His Val Glu Glu Pro Ser Pro
7475 7480 7485
His Val Asp Trp Ala Ser Gly Asp Val Ala Leu Leu Thr Glu Asn
7490 7495 7500
Gln Pro Trp Pro Asp Asp Ala Lys Leu Arg Arg Ala Gly Val Ser
7505 7510 7515
Ser Phe Gly Leu Ser Gly Thr Asn Ala His Val Val Leu Glu Gln
7520 7525 7530
Tyr Arg Ala Pro Ala Ala Pro Asp Ile Thr Thr Thr Glu His Glu
7535 7540 7545
Pro Leu Ala Trp Thr Leu Ser Ala Arg Asp Pro Lys Ala Leu Arg
7550 7555 7560
Glu Gln Ala Gly Arg Leu His Ala Ala Leu Thr Glu Ser Pro Gln
7565 7570 7575
Trp Arg Pro Leu Asp Ile Gly Tyr Ser Leu Ala Thr Thr Arg Ser
7580 7585 7590
Asn Phe Ala His Arg Ala Val Ala Val Gly Ser Asp Arg Glu Asp
7595 7600 7605
Leu Leu Arg Ala Leu Ser Lys Leu Ala Asp Gly Ser Ala Trp Pro
7610 7615 7620
Ala Leu Val Thr Ala Thr Ala Lys Asp Arg Arg Val Ala Tyr Leu
7625 7630 7635
Phe Asp Gly Gln Gly Ser Gln Arg Pro Asp Met Gly Ser Gly Leu
7640 7645 7650
Tyr Glu Arg Phe Pro Ala Phe Ala Arg Ala Trp Asp Arg Ile Ser
7655 7660 7665
Ala Glu Phe Gly Lys His Leu Asp His Ser Leu Thr Asp Val Tyr
7670 7675 7680
Leu Gly Arg Gly Asp Ala Ala Thr Ala Asp Leu Val Asp Asp Thr
7685 7690 7695
Leu Tyr Ala Gln Ala Gly Leu Phe Thr Met Glu Ile Ala Leu Phe
7700 7705 7710
Glu Leu Leu Ala Glu Trp Gly Val Arg Pro Asp Phe Val Ser Gly
7715 7720 7725
His Ser Ile Gly Glu Thr Ala Ala Ala Tyr Ala Ala Gly Val Leu
7730 7735 7740
Ser Leu Glu Asp Val Thr Thr Leu Ile Val Ala Arg Gly Arg Ala
7745 7750 7755
Leu Arg Gln Val Pro Pro Gly Ala Met Val Ala Leu Arg Ala Gly
7760 7765 7770
Glu Asp Glu Ala Arg Glu Phe Leu Gly Arg Thr Gly Ala Ala Leu
7775 7780 7785
Asp Leu Ala Ala Val Asn Ser Pro Thr Ser Val Val Val Ser Gly
7790 7795 7800
Ala Ser Glu Ala Val Ala Gly Phe Arg Ala Arg Trp Thr Glu Ser
7805 7810 7815
Gly Arg Glu Ala Arg Thr Leu Asn Val Arg His Ala Phe His Ser
7820 7825 7830
Arg His Val Glu Ala Val Leu Gly Glu Phe Arg Glu Val Leu Glu
7835 7840 7845
Ser Leu Thr Phe Arg Thr Pro Ala Leu Pro Val Val Ser Thr Val
7850 7855 7860
Thr Gly Arg Leu Ile Glu Pro Thr Glu Leu Ser Thr Ser Glu Tyr
7865 7870 7875
Trp Leu Arg Gln Val Arg Gln Thr Val Arg Phe His Asp Ala Val
7880 7885 7890
Arg Glu Leu Ser Gly Gln Gly Val Gly Thr Phe Val Glu Ile Gly
7895 7900 7905
Pro Ser Gly Ala Leu Ala Ser Ala Gly Leu Glu Cys Leu Gly Asp
7910 7915 7920
Glu Ala Ser Phe His Ala Val Gln Arg Pro Gly Ser Pro Gly Asp
7925 7930 7935
Val Cys Leu Met Thr Ala Val Ala Glu Leu His Ala Gly Gly Thr
7940 7945 7950
Thr Val Asp Trp Ala Thr Val Leu Ala Gly Gly Arg Ala Thr Asp
7955 7960 7965
Leu Pro Val Tyr Pro Phe Gln His Gly Ser Tyr Trp Leu Ala Pro
7970 7975 7980
Val Thr Arg Ala Ala Asp Gly Ala Pro Ser Ala Gly Val Pro Ala
7985 7990 7995
Pro Gly Glu Tyr Ala Arg Pro Ser Ala Pro Glu Glu Pro Arg Thr
8000 8005 8010
Met Leu Glu Leu Val Arg Leu Glu Ala Ala Ile Ala Leu Ser Ile
8015 8020 8025
Thr Asp Pro Gly Leu Ile Ala Asp Asp Ser Ser Phe Leu Asp Leu
8030 8035 8040
Gly Phe Asp Ser Ile Ser Ala Leu Arg Leu Ser Asn Arg Leu Ala
8045 8050 8055
Ala Val Thr Gly Leu Asp Leu Pro Pro Ser Leu Leu Phe Asp His
8060 8065 8070
Pro Thr Pro Ala Glu Leu Ala Ala Arg Leu Asp Glu Leu Ser Ala
8075 8080 8085
Ala Asp Leu Asp Gly Ala Gly Val Tyr Ala Leu Leu Glu Glu Ile
8090 8095 8100
Asp Glu Leu Asp Asp Glu Asp Leu Asp Met Thr Glu Glu Glu Gln
8105 8110 8115
Thr Ala Ile Ser Glu Leu Leu Thr Lys Leu Ser Ala Lys Trp Ser
8120 8125 8130
Arg
<210> 168
<211> 914
<212> PRT
<213> Streptomyces hygroscopicus
<400> 168
Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu
1 5 10 15
Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val
20 25 30
Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu
35 40 45
Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys
50 55 60
Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile
65 70 75 80
Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala
85 90 95
Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly
100 105 110
Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu
115 120 125
Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys
130 135 140
Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val
145 150 155 160
Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala
165 170 175
Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu
180 185 190
Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp
195 200 205
Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn
210 215 220
Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala
225 230 235 240
Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr
245 250 255
Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg
260 265 270
Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp
275 280 285
Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu
290 295 300
Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala
305 310 315 320
Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu
325 330 335
His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val
340 345 350
Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala
355 360 365
Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu
370 375 380
Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp
385 390 395 400
Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg
405 410 415
Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val
420 425 430
Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile
435 440 445
Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu
450 455 460
Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu
465 470 475 480
Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly
485 490 495
Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro
500 505 510
Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile
515 520 525
Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala
530 535 540
Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp
545 550 555 560
Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn
565 570 575
Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly
580 585 590
Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu
595 600 605
Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser
610 615 620
Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala
625 630 635 640
Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr
645 650 655
Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg
660 665 670
Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys
675 680 685
Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys
690 695 700
Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu
705 710 715 720
Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp
725 730 735
Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro
740 745 750
Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln
755 760 765
Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser
770 775 780
Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu
785 790 795 800
Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg
805 810 815
Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg
820 825 830
Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly
835 840 845
Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala
850 855 860
Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu
865 870 875 880
Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg
885 890 895
Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn
900 905 910
Ala Glu
<210> 169
<211> 12
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Construct
<400> 169
ctagggggtt gc 12
<210> 170
<211> 6
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Construct
<400> 170
gggggt 6
<210> 171
<211> 2685
<212> DNA
<213> Streptomyces hygroscopicus
<400> 171
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag 60
gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc 120
gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgtta 180
cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc 240
gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag 300
cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg 360
ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt 420
ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg 480
cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac 540
cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt 600
ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac 660
ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg 720
ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc 780
ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc 840
ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc 900
accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta 960
ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg 1020
gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc 1080
ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg 1140
gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg 1200
atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac 1260
ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg 1320
atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg 1380
cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg 1440
ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg 1500
gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc 1560
atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag 1620
cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac 1680
gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg 1740
tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc 1800
gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg 1860
ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc 1920
gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc 1980
ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac 2040
gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac 2100
gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac 2160
cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc 2220
cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg 2280
ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg 2340
ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg 2400
cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc 2460
ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag 2520
tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc 2580
gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc 2640
tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag 2685
<210> 172
<211> 2685
<212> DNA
<213> Streptomyces hygroscopicus
<400> 172
atgcctgccg tggagtgcta tgaactggac gcccgcgatg acgagctcag aaaactggag 60
gaggttgtga ccgggcgggc caacggccgg ggtgtggtgg tcaccatcac cggaccgatc 120
gcctgcggca agaccgaact gctcgacgca gccgccgcga aggccgacgc catcacgctg 180
cgagcggtct gctccgcgga ggaacaggca ctcccgtacg ccctgatcgg gcagctcatc 240
gacaacccgg cgctcgcctc ccacgcgctg gagccggcct gcccgaccct cccgggcgag 300
cacctgtcgc cggaggccga gaaccggctg cgcagcgacc tcacccgtac cctgctggcg 360
ctcgccgccg aacggccggt gctgatcggc atcgacgagt cacacgcgaa cgctttgtgt 420
ctgctccacc tggcccgaag ggtcggctcg gcccggatcg ccatggtcct caccgagttg 480
cgccggctca ccccggccca ctcacagttc caggccgagc tgctcagcct ggggcaccac 540
cgcgagatcg cgctgcgccc gctcagcccg aagcacaccg ccgagctggt ccgcgccggt 600
ctcggtcccg acgtcgacga ggacgtgctc acggggttgt accgggcgac cggcggcaac 660
ctgaacctca cccgcggact gatcaacgat gtgcgggagg cctgggagac gggagggacg 720
ggcatcagcg cgggccgcgc gtaccggctg gcatacctcg gttccctcta ccgctgcggc 780
ccggtcccgt tgcgggtcgc acgggtggcc gccgtgctgg gccagagcgc caacaccacc 840
ctggtgcgct ggatcagcgg gctcaacgcg gacgcggtgg gcgaggcaac cgagatcctc 900
accgaaggcg gcctgctgca cgacctgcgg ttcccgcacc cggcggcccg ttcggtggta 960
ctcaacgaca tgtccgccca ggaacgacgc cgcctgcacc ggtccgctct ggaagtgctg 1020
gacgacgtgc ccgtggaagt ggtcgcgcac caccaggtcg gcgccggtct cctgcacggc 1080
ccgaaggccg ccgagatatt cgccaaggcc ggccaggagc tgcatgtgcg cggcgagttg 1140
gacaccgcgt ccgactatct gcaactggcc caccaggcct ccgacgacgc cgtcaccggg 1200
atgcgggccg aggccgtggc gatcgagcgc cgccgcaacc cgctggcctc gagccggcac 1260
ctcgacgagc tgaccgtcgt cgcccgtgcc gggctgctct tccccgagca cacggcgctg 1320
atgatccgct ggctgggcgt cggcgggcgg tccggcgagg cagccgggct gctggcctcg 1380
cagcgccccc gtgcggtcac cgaccaggac agggcccata tgcgggccgc cgaggtatcg 1440
ctcgcgctgg tcagccccgg cacgtccggc ccggaccggc ggccgcgtcc gctcacgccg 1500
gatgagctcg cgaacctgcc gaaggcggcc cggctctgcg cgatcgccga caatgccgtc 1560
atgtcggccc tgcgcggtcg tcccgagctc gccgcggccg aggcggagaa cgtcctgcag 1620
cacgccgact cggcggcggc cggcaccacc gccctcgccg cgctgaccgc cttgctgtac 1680
gcggagaaca ccgacaccgc tcagctctgg gccgacaagc tggtctccga gaccggggcg 1740
tcgaacgagg aggaggcggg ctacgcgggg ccgcgcgccg aagccgcgtt gcgtcgcggc 1800
gacctggccg cggcggtcga ggcaggcagc accgttctgg accaccggcg gctctcgacg 1860
ctcggcatca ccgccgcgct accgctgagc agcgcggtgg ccgccgccat ccggctgggc 1920
gagaccgagc gggcggagaa gtggctcgcc cagccgctgc cgcaggccat ccaggacggc 1980
ctgttcggcc tgcacctgct ctcggcgcgc ggccagtaca gcctcgccac gggccagcac 2040
gagtcggcgt acacggcgtt tcgcacctgc ggggaacgta tgcggaactg gggcgttgac 2100
gtgccgggtc tgtccctgtg gcgcgtcgac gccgccgagg cgctgctgca cggccgcgac 2160
cgggacgagg gccgacggct cgtcgacgag caactcaccc gtgcgatggg accccgttcc 2220
cgcgccttga cgctgcgggt gcaggcggcg tacagcccgc cggcgaagcg ggtcgacctg 2280
ctcgatgaag cggccgacct gctgctctcc tgcaacgacc agtacgagcg ggcacgggtg 2340
ctcgccgacc tgagcgagac gttcagcgcg ctccggcacc acagccgggc gcggggactg 2400
cttcggcagg cccggcacct ggccgcccag cgcggcgcga taccgctgct gcgccgactc 2460
ggggccaagc ccggaggccc cggctggctg gaggaatccg gcctgccgca gcggatcaag 2520
tcgctgaccg acgcggagcg gcgggtggcg tcgctggccg ccggcggaca gaccaaccgc 2580
gtgatcgccg accagctctt cgtcacggcc agcacggtgg agcagcacct cacggacgtc 2640
tccactgggt caaggccgcc agcacctgcc gccgaactcg tctag 2685
<210> 173
<211> 2772
<212> DNA
<213> Streptomyces kanamyceticus
<400> 173
gtggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc 60
cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc 120
gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc 180
gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc 240
cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct 300
tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc 360
ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc 420
gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc 480
gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa 540
ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc 600
ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg 660
ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag 720
gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc 780
agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc 840
ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc 900
gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac 960
ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac 1020
gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac 1080
cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca 1140
cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac 1200
cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag 1260
cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc 1320
gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg 1380
cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag 1440
caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg 1500
gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc 1560
gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac 1620
cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc 1680
acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc 1740
tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac 1800
gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac 1860
ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg 1920
ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg 1980
ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg 2040
gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg 2100
gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg 2160
gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc 2220
gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gttacgggta 2280
caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg 2340
ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc 2400
tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc 2460
gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc 2520
ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg 2580
cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc 2640
gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag 2700
ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc 2760
cggtgcgggt ag 2772
<210> 174
<211> 2772
<212> DNA
<213> Streptomyces kanamyceticus
<400> 174
atggttcctg aagtgcgagc agcccccgac gaactgatcg cccgcgatga cgagctgagc 60
cgcctccaac gggcactcac cagggcgggg agcggaaggg gcggcgtcgt cgccatcacc 120
gggcccatcg ccagcggaaa gacggcgctg ctcgacgccg gagcggccaa gtccggcttc 180
gtcgcactcc gtgcggtgtg ctcctgggaa gagcgcactc tgccgtacgg gatgctgggc 240
cagctcttcg accatcccga actggccgcc caggcgccgg accttgccca cttcacggct 300
tcgtgcgaga gccctcaggc cggtaccgac aaccgcctgc gggccgagtt cacccgcacc 360
ctgctggcgc tcgccgcgga ctggcccgtc ctgatcggca tcgacgacgt gcaccacgcc 420
gacgcggaat cactgcgctg tctgctccac ctcgcccgcc gcatcggccc ggcccgcatc 480
gcggtcgtac tgaccgagct gcgcagaccg acgcccgccg actcccgctt ccaggcggaa 540
ctgctgagcc tgcgctccta ccaggagatc gcgctcagac cgctcaccga ggcgcagacc 600
ggcgaactcg tacgtcggca cctcggcgcg gagacccacg aggacgtctc cgccgatacg 660
ttccgggcga ccggcgggaa cctgctcctc gggcacggtt tgatcaatga catccgggag 720
gcgcggacag cgggacggcc gggggtcgtc gcggggcggg cgtaccggct cgcgtacctc 780
agctcgctct accgctgcgg cccgagcgcg ctgcgtgtcg cccgggcgtc cgccgtgctc 840
ggcgcgagcg ccgaagccgt gctcgtccag cggatgaccg gactgaacaa ggacgcggtc 900
gaacaggtct atgagcagct gaacgaggga cggctgctgc agggcgagcg gtttccgcac 960
ccggcggccc gctccatcgt ccttgacgac ctgtcggccc tggaacgcag aaacctgcac 1020
gagtcggcgc tggagctgct gcgggaccac ggcgtggccg gcaacgtgct cgcccgccac 1080
cagatcggcg ccggccgggt gcacggcgag gaggccgtcg agctgttcac cggggccgca 1140
cgggagcacc acctgcgcgg tgaactggac gacgcggccg gatacctgga actcgcccac 1200
cgtgcctccg acgaccccgt cacgcgcgcc gcactacgcg tcggcgccgc cgcgatcgag 1260
cgcctctgca atccggtacg ggcaggccgg catctgcccg agctgctcac cgcgtcgcgc 1320
gcgggactgc tctccagcga gcacgccgtg tcgctcgccg actggctggc gatgggcggg 1380
cgcccgggcg aggcggccga ggtcctcgcg acgcagcgtc ccgcggccga cagcgagcag 1440
caccgcgcac tcctgcgcag cggcgagttg tccctcgcgc tggtccaccc cggcgcgtgg 1500
gatccgttgc gccggaccga tcggttcgcc gcgggcgggc tcggctcgct tcccggaccc 1560
gcccggcacc gcgcggtcgc cgaccaagcc gtcatcgcgg cgctgcgtgg acgtctcgac 1620
cgggcggacg ccaacgcgga gagcgttctc cagcacaccg acgccacggc ggaccggacc 1680
acggccatca tggcgttgct ggccctgctc tacgcggaga acaccgatgc tgtccagttc 1740
tgggtcgaca aactggccgg tgacgagggc accaggacac cggccgacga ggcggtccac 1800
gcggggttca acgccgagat cgcgctgcgc cgcggcgact tgatgagagc cgtcgagtac 1860
ggcgaggcag cgctcggcca ccggcacctg cccacctggg gaatggccgc cgctctgccg 1920
ctgagcagca ccgtggttgc cgcgatccgg ctcggcgacc tcgacagggc cgagcggtgg 1980
ctcgccgagc cgctgccgca gcagacgccg gagagcctct tcgggctgca cctgctctgg 2040
gcccgcgggc agcaccacct cgcgaccggg cggcacgggg cggcgtacac ggcgttcagg 2100
gaatgcggcg agcggatgcg gcggtgggcc gtcgacgtgc cgggcctggc cctgtggcgg 2160
gtcgacgccg ccgaatcgct gctgctgctc ggccgtgacc gtgccgaagg actgcggctc 2220
gtctccgagc agctgtcccg gccgatgcgc cctcgcgcgc gcgtgcagac gctgcgggta 2280
caggcggcct acagtccgcc gccccaacgg atcgacctgc tcgaagaggc cgccgacctg 2340
ctggtcacct gcaacgacca gtacgaactg gcaaacgtac tcagcgactt ggcagaggcc 2400
tccagcatgg tccggcagca cagcagggcg cggggtctgc tccgccgggc acggcacctc 2460
gccacccagt gcggcgccgt gccgctcctg cggcggctcg gcgcggaacc ctcggacatc 2520
ggcggagcct gggacgcgac gctgggacag cggatcgcgt cactgacgga gtcggagcgg 2580
cgggtggccg cgctcgccgc ggtcgggcgt acgaacaggg agatcgccga gcagctgttc 2640
gtcacggcca gcacggtgga acagcacctc acgaacgtgt tccgcaaact ggcggtgaag 2700
ggccgccagc agcttccgaa ggaactggcc gacgtcggcg agccggcgga ccgcgaccgc 2760
cggtgcgggt ag 2772
<210> 175
<211> 2742
<212> DNA
<213> Streptomyces ascomyceticus
<400> 175
gtgatagcgc gcttatctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc 60
caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg 120
atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc 180
cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc 240
ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc 300
gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg 360
acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg 420
ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc 480
gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg 540
agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa 600
ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg 660
gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg 720
acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc 780
gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc 840
ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc 900
gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac 960
cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac 1020
gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac 1080
cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg 1140
cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac 1200
cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag 1260
cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg 1320
gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg 1380
cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag 1440
ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc 1500
gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc 1560
gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa 1620
caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc 1680
acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc 1740
tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac 1800
gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc 1860
ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg 1920
ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg 1980
ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg 2040
gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg 2100
gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg 2160
gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc 2220
atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg 2280
caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg 2340
ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg 2400
tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc 2460
gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg 2520
gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg 2580
cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc 2640
gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag 2700
ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga 2742
<210> 176
<211> 2742
<212> DNA
<213> Streptomyces ascomyceticus
<400> 176
atgatagcgc gcctgtctcc cccagacctg atcgcccgcg atgacgagtt cggttccctc 60
caccgggcgc tcacccgagc ggggggcggg cggggcgtcg tcgccgccgt caccgggccg 120
atcgcctgcg gcaagaccga actcctcgac gccgccgcgg ccaaggccgg cttcgtcacc 180
cttcgcgcgg tgtgctccat ggaggagcgg gccctgccgt acggcatgct cggccagctc 240
ctcgaccagc ccgagctggc cgcccggaca ccggagctgg tccggctgac ggcatcgtgc 300
gaaaacctgc cggccgacgt cgacaaccgc ctggggaccg aactcacccg cacggtgctg 360
acgctcgccg cggagcggcc cgtactgatc ggcatcgacg acgtgcacca cgccgacgcg 420
ccgtcgctgc gctgcctgct ccacctcgcg cgccgcatca gccgggcccg tgtcgccatc 480
gtgctgaccg agctgctccg gccgacgccc gcccactccc aattccgggc ggcactgctg 540
agtctgcgcc actaccagga gatcgcgctg cgcccgctca ccgaggcgca gaccaccgaa 600
ctcgtgcgcc ggcacctcgg ccaggacgcg cacgacgacg tggtggccca ggcgttccgg 660
gcgaccggcg gcaacctgct cctcggccac ggcctgatcg acgacatccg ggaggcacgg 720
acacggacct cagggtgcct ggaagtggtc gcggggcggg cgtaccggct cgcctacctc 780
gggtcgctct atcgttgcgg cccggccgcg ctgagcgtcg cccgagcttc cgccgtgctc 840
ggcgagagtg tcgaactcac cctcgtccag cggatgaccg gcctcgacac cgaggcggtc 900
gagcaggccc acgaacagct ggtcgagggg cggctgctgc gggaagggcg gttcccgcac 960
cccgcggccc gctccgtcgt actcgacgac ctctccgccg ccgagcggcg tggcctgcac 1020
gagctggcgc tggaactgct gcgggaccgc ggcgtggcca gcaaggtgct cgcccgccac 1080
cagatgggta ccggccgggt gcacggcgcc gaggtcgccg ggctgttcac cgacgccgcg 1140
cgcgagcacc acctgcgcgg cgagctcgac gaggccgtca cctacctgga gttcgcctac 1200
cgggcctccg acgaccccgc cgtccacgcc gcactgcgcg tcgacaccgc cgccatcgag 1260
cggctctgcg atcccgccag atccggccgg catgtgcccg agctgctcac cgcgtcgcgg 1320
gaacggctcc tctccagcga gcacgccgtg tcgctcgcct gctggctggc gatggacggg 1380
cggccgggcg aggccgccga ggtcctggcg gcccagcgct ccgccgcccc gagcgagcag 1440
ggccgggcgc acctgcgcgt cgcggacctg tccctcgcgc tgatctatcc cggcgcggcc 1500
gatccgccgc gtccggccga tccgccggcc gaggacgagg tcgcctcgtt ttccggagcc 1560
gtccggcacc gcgccgtcgc cgacaaggcc ctgagcaacg cgctgcgcgg ctggtccgaa 1620
caggccgagg ccaaagccga gtacgtgctc cagcactccc gggtcacgac ggaccggacc 1680
acgaccatga tggcgttgct ggccctgctc tacgccgagg acaccgatgc cgtccagtcc 1740
tgggtcgaca agctggccgg tgacgacaac atgcggaccc cggccgacga ggcggtccac 1800
gcggggttcc gcgccgaggc cgcgctgcgc cgcggcgacc tgaccgccgc cgtcgaatgc 1860
ggcgaggccg cgctcgcccc ccgggtcgtg ccctcctggg ggatggccgc cgcattgccg 1920
ctgagcagca ccgtggccgc cgcgatccga ctgggcgacc tggaccgggc ggagcggtgg 1980
ctcgccgagc cgttgccgga ggagacctcc gacagcctct tcggactgca catggtctgg 2040
gcccgtgggc aacaccatct cgcggccggg cggtaccggg cggcgtacaa cgcgttccgg 2100
gactgcgggg agcggatgcg acgctggtcc gtcgacgtgc cgggcctggc cctgtggcgg 2160
gtcgacgccg ccgaagcgct tctgctgctc ggccgcggcc gtgacgaggg gctgaggctc 2220
atctccgagc agctgtcccg gccgatgggg tcccgggcgc gggtgatgac gctgcgggtg 2280
caggcggcct acagtccgcc ggccaagcgg atcgaactgc tcgacgaggc cgccgatctg 2340
ctcatcatgt gccgcgacca gtacgagctg gcccgcgtcc tcgccgacat gggcgaagcg 2400
tgcggcatgc tccggcggca cagccgtgcg cggggactgt tccgccgcgc acggcacctc 2460
gcgacccagt gcggagccgt gccgctcctc cggcggctcg gtggggagtc ctcggacgcg 2520
gacggcaccc aggacgtgac gccggcgcag cggatcacat cgctgaccga ggcggagcgg 2580
cgggtggcgt cgcacgccgc ggtcgggcgc accaacaagg agatcgccag ccagctgttc 2640
gtcacctcca gcacggtgga acagcacctc accaacgtgt tccgcaagct gggggtgaag 2700
ggccgtcagc aactgcccaa ggaactgtcc gacgccggct ga 2742
<210> 177
<211> 2706
<212> DNA
<213> Micromonospora sp. S92-306401
<400> 177
gtggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc 60
ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc 120
aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc 180
tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc 240
gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg 300
gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc 360
gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac 420
tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag 480
ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac 540
cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc 600
cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg 660
aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc 720
acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt 780
ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc 840
acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc 900
ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc 960
gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg 1020
ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac 1080
ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag 1140
ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc 1200
cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc 1260
agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac 1320
gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg 1380
ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc 1440
gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg 1500
ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg 1560
gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg 1620
cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc 1680
tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg 1740
gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc 1800
gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg 1860
ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc 1920
gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc 1980
ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac 2040
gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac 2100
gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac 2160
cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca 2220
cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg 2280
ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg 2340
ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc 2400
ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg 2460
ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg 2520
accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc 2580
gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc 2640
aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg 2700
ggctga 2706
<210> 178
<211> 2706
<212> DNA
<213> Micromonospora sp. S92-306401
<400> 178
atggagtttt acgacctggt cgcccgcgat gacgagctca gaaggttgga ccaggccctc 60
ggccgcgccg ccggcggacg gggtgtcgtg gtcaccgtca ccggaccggt cggctgcggc 120
aagaccgaac tgctggacgc ggccgcggcc gaggaggaat tcatcacgtt gcgtgcggtc 180
tgctcggccg aggagcgggc cctgccgtac gccgtgatcg gccaactcct cgaccatccc 240
gtactctccg cacgcgcgcc cgacctggcc tgcgtgacgg ctccgggccg gacgctgccg 300
gccgacaccg agaaccgcct gcgccgcgac ctcacccggg ccctgctggc cctggcctcc 360
gaacgaccgg ttctgatctg catcgacgac gtgcaccagg ccgacaccgc ctcgctgaac 420
tgcctgctgc acctggcccg gcgggtcgcc tcggcccgga tcgccatgat cctcaccgag 480
ttgcgccggc tcaccccggc tcactcccgg ttcgaggcgg aactgctcag cctgcggcac 540
cgccacgaga tcgcgctgcg tcccctcggc ccggccgaca ccgccgaact ggcccgcgcc 600
cggctcggcg ccggcgtcac cgccgacgag ctggcccagg tccacgaggc caccagcggg 660
aaccccaacc tggtcggagg cctggtcaac gacgtgcgag aggcctgggc ggccggtggc 720
acgggcattg cggcggggcg ggcgtaccgg ctggcgtacc tcagctccgt gtaccgctgt 780
ggtccggtcc cgttgcggat cgcccaggcg gcggcggtgc tgggtcccag cgccaccgtc 840
acgctggtgc gccggatcag cgggctcgac gccgagacgg tggacgaggc gaccgcgatc 900
ctcaccgagg gcggcctgct ccgggaccac cggttcccgc atccggcggc ccgctcggtc 960
gtactcgacg acatgtccgc gcaggaacgc cgccgcctgc accggtccac gctggacgtg 1020
ctggacggcg tacccgtcga cgtgctcgcg caccaccagg ccggcgccgg tctgctgcac 1080
ggcccgcagg cggccgagat gttcgcccgg gccagccagg agctgcgggt acgcggcgag 1140
ctggacgccg cgaccgagta cctgcaactg gcctaccggg cctccgacga cgccggcgcc 1200
cgggccgccc tgcaggtgga gaccgtggcc ggcgagcgcc gccgcaaccc gctggccgcc 1260
agccggcacc tggacgagct ggccgccgcc gcccgggccg gcctgctgtc ggccgagcac 1320
gccgccctgg tcgtgcactg gctggccgac gccggacgac ccggcgaggc cgccgaggtg 1380
ctggcgctgc agcgggcgct ggccgtcacc gaccacgacc gggcccgcct gcgggcggcc 1440
gaggtgtcgc tcgcgctgtt ccaccccggc gtccccggtt cggacccgcg gcccctcgcg 1500
ccggaggagc tcgcgagcct gtccctgtcg gcccggcacg gtgtgaccgc cgacaacgcg 1560
gtgctggcgg cgctgcgcgg ccgtcccgag tcggccgccg ccgaggcgga gaacgtgctg 1620
cgcaacgccg acgccgccgc gtccggcccg accgccctgg ccgcgctgac ggccctgctc 1680
tacgccgaga acaccgacgc cgcccagctc tgggcggaca agctggccgc gggcatcggg 1740
gcgggggagg gggaggccgg ctacgcgggg ccgcggaccg tggccgccct gcgtcgcggc 1800
gacctgacca ccgcggtcca ggcggccggc gcggtcctgg accgcggccg gccgtcgtcg 1860
ctcggcatca ccgccgtgtt gccgttgagc ggcgcggtcg ccgccgcgat ccggctgggc 1920
gagctcgagc gggccgagaa gtggctggcc gagccgctgc ccgaagccgt ccacgacagc 1980
ctgttcggcc tgcacctgct gatggcgcgg ggccgctaca gcctcgcggt gggccggcac 2040
gaggcggcgt acgccgcgtt ccgggactgc ggtgaacgga tgcgccggtg ggacgtcgac 2100
gtgcccgggc tggccctgtg gcgggtggac gcggccgagg cgctgctgcc cggcgatgac 2160
cgggcggagg gccggcggct gatcgacgag cagctcaccc ggccgatggg gccccggtca 2220
cgagccctga ccctgcgggt acgagcggcc tacgccccgc cggcgaaacg gatcgacctg 2280
ctcgacgaag cggccgacct gctgctctcc agcaacgacc agtacgagcg ggcacgggtg 2340
ctggccgacc tgagcgaggc gttcagcgcg ctccggcaga acggccgggc gcgcggcatc 2400
ctgcggcagg cccggcacct ggccgcccag tgcggggcgg tccccctgct gcgccggctg 2460
ggcgtcaagg ccggccggtc cggtcggctc ggccggccgc cgcagggaat ccgctccctg 2520
accgaggccg agcgccgggt ggccacgctg gccgccgccg ggcagaccaa ccgggagatc 2580
gccgaccagc tcttcgtcac cgccagcacg gtcgagcagc acctcaccaa cgtgttccgc 2640
aagctcggcg tgaagggccg ccagcaattg ccggccgagc tggccgacct gcggccgccg 2700
ggctga 2706
<210> 179
<211> 2616
<212> DNA
<213> Streptomyces violaceusniger
<400> 179
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc 60
gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg 120
tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg 180
gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg 240
gatctcaccc gtgccctgct ggcgcttgcc gtcgaccggc ctgtgctgat cggcgtcgac 300
gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc gcgccgggtc 360
cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca 420
cggttcaagg cggagctgct cagcctgccg taccaccacg agatcgcgct gcgtccgttc 480
ggaccggagc aatcggcgga gctggcccgc gccgccttcg gcccgggcct cgccgaggat 540
gtgctcgtgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc 600
agcgatgtgc gggaggccct ggccaacgga gagagcgcct tcgaggcggg ccgcgcgttc 660
cggctggcgt acctcggctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga 720
gtggctgccg tgctgggccc gagcgccacc accacgctgg tgcgccgtct aagcgggctc 780
agcgcggaga cgatagaccg ggcaaccaag atcctcaccg agggcgggct gctgctcgac 840
cagcagttcc cgcacccggc cgcccgctcg gtggtgcttg atgacatgtc cgcccaggaa 900
cgacgcggcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc 960
gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc 1020
aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggcaga atacctgcaa 1080
ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg 1140
gcgatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga gctgagcgcc 1200
gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctggcc 1260
gacggcgggc gatccggcga ggcagccgag gtgctggcgt cggaacgccc gctagcgacc 1320
accgatcaga accgggccca cttgcgattt gtcgaggtga ctctcgcgct gttctctccc 1380
ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg 1440
ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggt 1500
catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc 1560
gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat 1620
atctgggccg acaagctggg cagcacgaat ggcggggtat cgaacgaggc ggaagcgggc 1680
tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag 1740
gctggtagca ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg 1800
ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag 1860
ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc 1920
tcggcatacg gccagtacag cctcgcgatg ggccgatatg aatcggctct ccgggcgttt 1980
cacacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg 2040
cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc 2100
gacgaacaac tcacccgtcc gatggggcct cgttcccgcg cgttaacgct gcggatcaag 2160
gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg 2220
ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc 2280
agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc 2340
gcccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac 2400
gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg 2460
ctggccgcgg ccggacagac caaccgggag atcgccaaac agctgttcgt cacggccagc 2520
acagtggaac agcacctcac aagcgtcttc cgcaaactgg gggtcaaggg tcgcaagcag 2580
ctgccgaccg cgctggccga cgtggaacag acctga 2616
<210> 180
<211> 2721
<212> DNA
<213> Streptomyces violaceusniger
<400> 180
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc 60
attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc 120
ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc 180
atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc 300
cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag 540
ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cgttcggacc ggagcaatcg 600
gcggagctgg cccgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgtggggttg 660
tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gccctggcca acggagagag cgccttcgag gcgggccgcg cgttccggct ggcgtacctc 780
ggctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccgagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gttcccgcac 960
ccggccgccc gctcggtggt gcttgatgac atgtccgccc aggaacgacg cggcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct 1140
ctggtcgtac gcaacgagtt gggcgacgcg gcagaatacc tgcaactggc tcaccgggcc 1200
tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc 1260
cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc 1380
ggcgaggcag ccgaggtgct ggcgtcggaa cgcccgctag cgaccaccga tcagaaccgg 1440
gcccacttgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg 1500
gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggtcatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc 1680
gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag 1740
ctgggcagca cgaatggcgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc 1860
ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg 1980
cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc atacggccag 2040
tacagcctcg cgatgggccg atatgaatcg gctctccggg cgtttcacac ctgcggagaa 2100
cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc 2160
gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc 2220
cgtccgatgg ggcctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccgccca gtgcggtgct 2460
gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga 2580
cagaccaacc gggagatcgc caaacagctg ttcgtcacgg ccagcacagt ggaacagcac 2640
ctcacaagcg tcttccgcaa actgggggtc aagggtcgca agcagctgcc gaccgcgctg 2700
gccgacgtgg aacagacctg a 2721
<210> 181
<211> 2745
<212> DNA
<213> Streptomyces hygroscopicus
<400> 181
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag 60
gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc 120
gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacatta 180
cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc 240
gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag 300
cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg 360
ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc 420
tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc 480
ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc 540
ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg 600
gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg 660
accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg 720
acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc 780
taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc 840
gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg 900
accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc 960
cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct 1020
ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt 1080
ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg 1140
cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac 1200
gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg 1260
ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc 1320
ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg 1380
gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg 1440
cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt 1500
gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg 1560
aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt 1620
cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac 1680
ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct 1740
cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg 1800
ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc 1860
gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg 1920
ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag 1980
aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg 2040
ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg 2100
ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg 2160
tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg 2220
ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg 2280
gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac 2340
ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag 2400
gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac 2460
ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc 2520
cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag 2580
cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc 2640
ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc 2700
aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag 2745
<210> 182
<211> 2745
<212> DNA
<213> Streptomyces hygroscopicus
<400> 182
atgcctgccg tggagagcta tgaactggac gcccgcgatg acgagctcag aagactggag 60
gaggcggtag gccaggcggg caacggccgg ggtgtggtgg tcaccatcac cgggccgatc 120
gcctgcggca agaccgaact gctcgacgcg gccgccgcga agagcgacgc catcacactg 180
cgtgcggtct gctccgagga ggaacgggcc ctcccgtacg ccctgatcgg gcagctcatc 240
gacaacccgg cggtcgcctc ccagctgccg gatccggtct ccatggccct cccgggcgag 300
cacctgtcgc cggaggccga gaaccggctg cgcggcgacc tcacccgtac cctgctggcg 360
ctcgccgccg aacggccggt gctgatcggc atcgacgaca tgcaccacgc cgacaccgcc 420
tctttgaact gcctgctcca cctggcccgg agggtcggcc cggcccggat cgccatggtc 480
ctcaccgagc tgcgccggct caccccggcc cactcccagt tccacgccga gctgctcagc 540
ctggggcacc accgcgagat cgcgctgcgc ccgctcggcc cgaagcacat cgccgagctg 600
gcccgcgccg gcctcggtcc cgatgtcgac gaggacgtgc tcacggggtt gtaccgggcg 660
accggcggca acctgaacct cggccacgga ctgatcaagg atgtgcggga ggcctgggcg 720
acgggcggga cgggcatcaa cgcgggccgc gcgtaccggc tggcgtacct cggttccctc 780
taccgctgcg gcccggtccc gttgcgggtc gcacgggtgg ccgccgtgct gggccagagc 840
gccaacacca ccctggtgcg ctggatcagc gggctcaacg cggacgcggt gggcgaggcg 900
accgagatcc tcaccgaggg cggcctgctg cacgacctgc ggttcccgca tccggcggcc 960
cgttcggtcg tactcaacga cctgtccgcc cgggaacgcc gccgactgca ccggtccgct 1020
ctggaagtgc tggatgacgt acccgttgaa gtggtcgcgc accaccaggc cggtgccggt 1080
ttcatccacg gtcccaaggc cgccgagatc ttcgccaagg ccggccagga gctgcatgtg 1140
cgcggcgagc tggacgccgc gtccgactat ctgcaactgg cccaccacgc ctccgacgac 1200
gccgtcaccc gggccgcgct gcgggtcgag gccgtggcga tcgagcgccg ccgcaacccg 1260
ctggcctcca gccgccacct cgacgagctg accgtcgccg cccgtgccgg tctgctctcc 1320
ctcgagcacg ccgcgctgat gatccgctgg ctggctctcg gcgggcggtc cggcgaggcg 1380
gccgaggtgc tggccgcgca gcgcccgcgt gcggtcaccg accaggacag ggcccacctg 1440
cgggccgccg aggtatcgct ggcgctggtc agcccgggcg cgtccggcgt cagcccgggt 1500
gcgtccggcc cggatcggcg gccgcgtccg ctcccgccgg atgagctcgc gaacctgccg 1560
aaggcggccc ggctttgtgc gatcgccgac aacgccgtca tatcggccct gcacggtcgt 1620
cccgagcttg cctcggccga ggcggagaac gtcctgaagc aggctgactc ggcggcggac 1680
ggcgccaccg ccctctccgc gctgacggcc ttgctgtacg cggagaacac cgacaccgct 1740
cagctctggg ccgacaagct cgtctccgag accggggcgt cgaacgagga ggaaggcgcg 1800
ggctacgcgg ggccgcgcgc cgagaccgcg ttgcgccgcg gcgacctggc cgcggcggtc 1860
gaggcgggca gcgccattct ggaccaccgg cgggggtcgt tgctcggcat caccgccgcg 1920
ctaccgctga gcagcgcggt agccgccgcc atccggctgg gcgagaccga gcgggcggag 1980
aagtggctcg ccgagccgct gccggaggcc attcgggaca gcctgttcgg gctgcacctg 2040
ctctcggcgc gcggccagta ctgcctcgcg acgggccggc acgagtcggc gtacacggcg 2100
ttccgcacct gcggggaacg gatgcggaac tggggcgtcg acgtgccggg tctgtccctg 2160
tggcgcgtcg acgccgccga ggcgctgctg cacggccgcg accgggacga gggccgacgg 2220
ctcatcgacg agcagctcac ccatgcgatg ggaccccgtt cccgcgcttt gacgctgcgg 2280
gtgcaggcgg cgtacagccc gcaggcgcag cgggtcgacc tgctcgaaga ggcggccgac 2340
ctgctgctct cctgcaacga ccagtacgag cgggcgcggg tgctcgccga tctgagcgag 2400
gcgttcagcg cgctcaggca ccacagccgg gcgcggggac tgctccggca ggcccggcac 2460
ctggccgccc agtgcggcgc gaccccgctg ctgcgccggc tcggggccaa gcccggaggc 2520
cccggctggc tggaggaatc cggcctgccg cagcggatca agtcgctgac cgacgcggag 2580
cggcgggtgg cgtcgctggc cgccggcggc cagaccaacc gcgtgatcgc cgaccagctc 2640
ttcgtcacgg ccagcacggt ggagcagcac ctcacgaacg tcttccgcaa gctgggcgtc 2700
aagggccgcc agcacctgcc ggccgaactc gccaacgcgg aatag 2745
<210> 183
<211> 2619
<212> DNA
<213> Actinoplanes sp. N01-109
<400> 183
gtgaagcgca acgatctggt tgcccgcgat ggcgagctca ggtggatgca agagattctc 60
agtcaggcga gcgagggccg gggggccgtg gtcaccatca cgggggcgat cgcctgtggc 120
aagacggtgc tgctggacgc cgcggcagcc agtcaagacg tgatccaact gcgtgcggtc 180
tgctcggcgg aggagcagga gctgccgtac gcgatggtcg gacaactact cgacaatccg 240
gtgctcgccg cgcgagtgcc ggccctgggc aacctggctg cggcgggcga gcggctgctg 300
ccgggcaccg agaacaggat ccggcgggag ctcacccgca ccctgctggc tctcgccgac 360
gaacgaccgg tgctgatcgg cgtcgacgac atgcaccatg cggaccccgc ctcgctggac 420
tgcctgctgc acctggcccg gcgggtcggc ccggcccgca tcgcgatcgt tctgaccgag 480
ttgcgccggc tcaccccggc tcactcgcgc ttccagtccg agctgctcag cctgcggtac 540
caccacgaga tcgggttgca gccgctcacc gcggagcaca ccgccgacct ggcccgcgtc 600
ggcctcggtg ccgaggtcga cgacgacgtg ctcaccgagc tctacgaggc gaccggcggc 660
aacccgagtc tgtgctgcgg cctgatcagg gacgtgcggc aggactggga ggccggggtc 720
accggtatcc acgtcggccg ggcgtaccgg ctggcctatc tcagttcgct ctaccgctgc 780
ggcccggcgg cgctgcggac cgcccgcgcg gccgcggtgc tgggcgacag cgccgacgcc 840
tgcctgatcc gccgggtcag cggcctcggt acggaggccg tgggccaggc gatccagcag 900
ctcaccgagg gcggcctgct gcgtgaccag cagttcccgc acccggcggc ccgctcggtc 960
gtgctcgacg acatgtccgc gcaggaacgc cacgcgatgt atcgcagcgc ccgggaggca 1020
gccgccgaag gtcaggccga ccccggcacc ccgggcgagc cgcgggcggc tacggcgtac 1080
gccgggtgtg gtgagcaagc cggtgactac ccggagccgg ccggccgggc ctgcgtggac 1140
ggtgccggtc cggccgagta ctgcggcgac ccgcacggcg ccgacgacga cccggacgag 1200
ctggtcgccg cgctgggcgg gctgctgccg agccggctcg tggcgatgaa gatccggcgc 1260
ctggcggtgg ccgggcgccc cggggcggct gccgagctgc tgacctcgca gcggttgcac 1320
gcggtgacca gcgaggaccg ggccagcctg cgggccgccg aggtggcgct cgccacgctg 1380
tggccgggtg cgaccggccc ggaccggcat ccgctcacgg agcaggaggc ggcgagcctg 1440
ccggagggtc cgcgcctgct cgctgccgcc gacgatgccg tcggggccgc cctgcgcggt 1500
cgcgccgagt acgccgcggc cgaggcggag aacgtcctgc ggcacgccga tccggcagcc 1560
ggtggtgacg cctacgccgc catgatcgcc ctgctgtaca cggagcaccc cgagaacgtg 1620
ctgttctggg ccgacaagct cgacgcgggc cgccccgacg aggagaccag ttatcccggg 1680
ctgcgggccg agaccgcggt gcggctcggt gacctggaaa cggcgatgga gctgggccgc 1740
acggtgctgg accagcggcg gctgccgtcc ctgggtgtcg ccgcgggcct gctcctgggc 1800
ggcgcggtga cggccgccat ccggctcggc gacctcgacc gggcggagaa gtggctcgcc 1860
gagccgatcc ccgacgccat ccgtaccagc ctctacggcc tgcacgtgct ggccgcgcgg 1920
ggccggctcg acctggccgc gggccgctac gaggcggcgt acacggcgtt ccggctgtgt 1980
ggcgagcgga tggcaggctg ggatgccgat gtctccgggc tggcgctgtg gcgcgtcgac 2040
gccgccgagg ccctgctgtc cgcgggcatc cgcccggacg agggccgcaa gctcatcgac 2100
gaccagctca cccgtgagat gggggcccgc tcccgggcgc tgacgctgcg ggcgcaagcg 2160
gcgtacagcc tgccggtgca ccgggtgggc ctgctcgacg aggcggccgg cctgctgctc 2220
gcctgccatg acgggtacga gcgggcgcgg gtgctcgcgg acctggggga gaccctgcgc 2280
acgctgcggc acaccgacgc ggcccagcgg gtgctccggc aggccgagca ggcggccgcg 2340
cggtgcgggt cggtcccgct gctgcggcgg ctcggggccg aacccgtacg catcggcacc 2400
cggcgtggtg aacccggcct gccgcagcgg atcaggctgc tgaccgatgc cgagcggcgg 2460
gttgccgcga tggccgccgc cgggcagacc aaccgggaga tcgccggtcg gctcttcgtc 2520
acggccagca cggtggagca gcacctgacc agcgtcttcc gcaagctggg cgtcaagggc 2580
cgccggttcc tgccgaccga gctcgcccaa gccgtctga 2619
<210> 184
<211> 2628
<212> DNA
<213> Actinoplanes sp. N01-109
<400> 184
atgcctgccg tgaagcgcaa cgatctggtt gcccgcgatg gcgagctcag gtggatgcaa 60
gagattctca gtcaggcgag cgagggccgg ggggccgtgg tcaccatcac gggggcgatc 120
gcctgtggca agacggtgct gctggacgcc gcggcagcca gtcaagacgt gatccaactg 180
cgtgcggtct gctcggcgga ggagcaggag ctgccgtacg cgatggtcgg acaactactc 240
gacaatccgg tgctcgccgc gcgagtgccg gccctgggca acctggctgc ggcgggcgag 300
cggctgctgc cgggcaccga gaacaggatc cggcgggagc tcacccgcac cctgctggct 360
ctcgccgacg aacgaccggt gctgatcggc gtcgacgaca tgcaccatgc ggaccccgcc 420
tcgctggact gcctgctgca cctggcccgg cgggtcggcc cggcccgcat cgcgatcgtt 480
ctgaccgagt tgcgccggct caccccggct cactcgcgct tccagtccga gctgctcagc 540
ctgcggtacc accacgagat cgggttgcag ccgctcaccg cggagcacac cgccgacctg 600
gcccgcgtcg gcctcggtgc cgaggtcgac gacgacgtgc tcaccgagct ctacgaggcg 660
accggcggca acccgagtct gtgctgcggc ctgatcaggg acgtgcggca ggactgggag 720
gccggggtca ccggtatcca cgtcggccgg gcgtaccggc tggcctatct cagttcgctc 780
taccgctgcg gcccggcggc gctgcggacc gcccgcgcgg ccgcggtgct gggcgacagc 840
gccgacgcct gcctgatccg ccgggtcagc ggcctcggta cggaggccgt gggccaggcg 900
atccagcagc tcaccgaggg cggcctgctg cgtgaccagc agttcccgca cccggcggcc 960
cgctcggtcg tgctcgacga catgtccgcg caggaacgcc acgcgatgta tcgcagcgcc 1020
cgggaggcag ccgccgaagg tcaggccgac cccggcaccc cgggcgagcc gcgggcggct 1080
acggcgtacg ccgggtgtgg tgagcaagcc ggtgactacc cggagccggc cggccgggcc 1140
tgcgtggacg gtgccggtcc ggccgagtac tgcggcgacc cgcacggcgc cgacgacgac 1200
ccggacgagc tggtcgccgc gctgggcggg ctgctgccga gccggctcgt ggcgatgaag 1260
atccggcgcc tggcggtggc cgggcgcccc ggggcggctg ccgagctgct gacctcgcag 1320
cggttgcacg cggtgaccag cgaggaccgg gccagcctgc gggccgccga ggtggcgctc 1380
gccacgctgt ggccgggtgc gaccggcccg gaccggcatc cgctcacgga gcaggaggcg 1440
gcgagcctgc cggagggtcc gcgcctgctc gctgccgccg acgatgccgt cggggccgcc 1500
ctgcgcggtc gcgccgagta cgccgcggcc gaggcggaga acgtcctgcg gcacgccgat 1560
ccggcagccg gtggtgacgc ctacgccgcc atgatcgccc tgctgtacac ggagcacccc 1620
gagaacgtgc tgttctgggc cgacaagctc gacgcgggcc gccccgacga ggagaccagt 1680
tatcccgggc tgcgggccga gaccgcggtg cggctcggtg acctggaaac ggcgatggag 1740
ctgggccgca cggtgctgga ccagcggcgg ctgccgtccc tgggtgtcgc cgcgggcctg 1800
ctcctgggcg gcgcggtgac ggccgccatc cggctcggcg acctcgaccg ggcggagaag 1860
tggctcgccg agccgatccc cgacgccatc cgtaccagcc tctacggcct gcacgtgctg 1920
gccgcgcggg gccggctcga cctggccgcg ggccgctacg aggcggcgta cacggcgttc 1980
cggctgtgtg gcgagcggat ggcaggctgg gatgccgatg tctccgggct ggcgctgtgg 2040
cgcgtcgacg ccgccgaggc cctgctgtcc gcgggcatcc gcccggacga gggccgcaag 2100
ctcatcgacg accagctcac ccgtgagatg ggggcccgct cccgggcgct gacgctgcgg 2160
gcgcaagcgg cgtacagcct gccggtgcac cgggtgggcc tgctcgacga ggcggccggc 2220
ctgctgctcg cctgccatga cgggtacgag cgggcgcggg tgctcgcgga cctgggggag 2280
accctgcgca cgctgcggca caccgacgcg gcccagcggg tgctccggca ggccgagcag 2340
gcggccgcgc ggtgcgggtc ggtcccgctg ctgcggcggc tcggggccga acccgtacgc 2400
atcggcaccc ggcgtggtga acccggcctg ccgcagcgga tcaggctgct gaccgatgcc 2460
gagcggcggg ttgccgcgat ggccgccgcc gggcagacca accgggagat cgccggtcgg 2520
ctcttcgtca cggccagcac ggtggagcag cacctgacca gcgtcttccg caagctgggc 2580
gtcaagggcc gccggttcct gccgaccgag ctcgcccaag ccgtctga 2628
<210> 185
<211> 2616
<212> DNA
<213> Streptomyces malaysiensis
<400> 185
gtggtcaccg tcaccggccc aatcgcctgc ggcaagacag aactgcttga cgcggctgcc 60
gcgaaggctg aggccatcat tctgcgcgcg gtctgcgcgc cagaagagcg ggctatgccg 120
tacgccatga tcgggcagct catcgacgac ccggcgctcg cgcatcgggc gccggggctg 180
gctgatcgga tagcccaggg cgggcagctg tcgctgaggg ccgagaaccg actgcgcagg 240
gatctcaccc gtgccctgct ggcgcttgcc gtggaccggc ctgtgctgat cggcgtcgac 300
gatgtgcatc acgccgacac cgcctctttg aactgtctgc tgcatttggc ccgccgggtc 360
cgtccggccc ggatatccat gatcttcacc gagttgcgca gcctcacccc tactcagtca 420
cggttcaagg cggagctgct cagcctgcca taccaccacg agatcgcgct gcgtccattc 480
ggaccggagc aatcggcgga gctggctcgc gccgccttcg gcccgggcct cgccgaggat 540
gtgctcgcgg ggttgtataa aacgaccagg ggcaatctga gtctcagccg tggactgatc 600
agcgatgtgc gggaggccct ggccaacgga gagagcgctt tcgaggcggg ccgcgcgttc 660
cggctggcgt acctcagctc gctctaccgc tgtggcccgg tcgcgctgcg ggtcgcccga 720
gtggctgccg tgctgggccc aagcgccacc accacgctgg tgcgccggct aagcgggctc 780
agcgcggaga cgatagaccg ggcaaccaag atcctcactg agggcgggct gctgctcgac 840
cagcagttcc cgcacccggc cgcccgctcg gtggtgctcg atgacatgtc cgcccaggaa 900
cgacgcagcc tgcacactct cgccctggaa ctgctggacg aggcgccggt tgaagtgctc 960
gcgcaccacc aggtcggcgc cggtctcata cacgggccca aggctgcgga gatgttcgcc 1020
aaggccggca aggctctggt cgtacgcaac gagttgggcg acgcggccga atacctgcaa 1080
ctggctcacc gggcctccga cgatgtctcc acccgggccg ccttacgggt cgaggccgtg 1140
gccatcgagc gccgccgcaa tccgctggcc tccagtcggc acatggacga actgagcgcc 1200
gccggccgcg ccggtctgct ttcccccaag catgcggcgc tggccgtctt ctggctagcc 1260
gacggcgggc gatccggcga ggcagccgaa gtgctggcgt cggaacgccc gctcgcgacc 1320
accgatcaga accgggccca cctgcgattt gtcgaggtga ctctcgcgct gttctctccc 1380
ggcgccttcg gatcggaccg gcgcccacct ccgctgacgc cggacgaact cgccagcctg 1440
ccgaaggcgg cctggcaatg cgcggtcgcc gacaacgcgg ccatgaccgc cttgcacggc 1500
catccagaac ttgccaccgc tcaggcggaa acagttctgc ggcaggctga ttcggcagcc 1560
gacgcgatcc ccgccgcgct gatcgccctg ttgtacgcgg agaacaccga gtccgctcat 1620
atctgggccg acaagctggg cagcacgaat gccggggtat cgaacgaggc ggaagcgggc 1680
tacgccggcc cgtgcgccga gatcgccctg cggcgcggcg acctggccac ggcgttcgag 1740
gctggtagcg ccgtcctgga cgaccggtcg ctgccgtcgc tcggcatcac cgccgcattg 1800
ctgttgagca gcaagacggc cgccgctgtc cggctgggcg aactcgagcg tgcggagaag 1860
ctgctcgccg agccgcttcc gaacggcgtc caggacagcc ttttcggtct gcacctgctc 1920
tcggcgtacg gccagtacag cctcgcgatg ggccgatatg aatcagctca ccgggcgttt 1980
cgcacctgcg gagaacgtat gcgcagctgg gatgttgacg tgcctggtct ggccctgtgg 2040
cgtgtcgacg ccgccgaggc gctgctcagc ctcgaccgga acgagggcca gcggctcatc 2100
gacgaacaac tcacccgtcc gatggggcct cgttcccacg cgttaacgct gcggatcaag 2160
gcggcatacc tcccgcggac gaagcggatc cccctgctcc atgaggcggc cgagctgctg 2220
ctcccctgcc ccgacccgta cgagcaagcg cgggtgctcg ccgatctggg cgacacgctc 2280
agcgcgctca gacgctatag ccgggcgcgg ggagttctcc ggcaggctcg tcacctggcc 2340
acccagtgcg gtgctgtccc gctgctgcgc aggctcgggg gcgagcccgg ccggatcgac 2400
gacgccggcc tgccgcagcg gagcacatcg ttgaccgatg cggagcggcg ggtggcggcg 2460
ctggccgcgg ccggacagac caaccgggag atcgccgaac agctgttcgt cacggccagc 2520
acagtggaac agcacctcac aagcgtcttc cgcaagctgg gcgtcaaggg ccgcaagcag 2580
ctgccgaccg cgctggccga cgtggaacag acctga 2616
<210> 186
<211> 2721
<212> DNA
<213> Streptomyces malaysiensis
<400> 186
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggt 60
attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc 120
ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc 180
atcattctgc gcgcggtctg cgcgccagaa gagcgggcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc 300
cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtgga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ttggcccgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacggtt caaggcggag 540
ctgctcagcc tgccatacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg 600
gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg 660
tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc 780
agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccagca gttcccgcac 960
ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct 1140
ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc 1200
tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggccat cgagcgccgc 1260
cgcaatccgc tggcctccag tcggcacatg gacgaactga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tagccgacgg cgggcgatcc 1380
ggcgaggcag ccgaagtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg 1440
gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg 1500
gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc 1680
gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag 1740
ctgggcagca cgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcgccgtc 1860
ctggacgacc ggtcgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg 1980
cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag 2040
tacagcctcg cgatgggccg atatgaatca gctcaccggg cgtttcgcac ctgcggagaa 2100
cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc 2160
gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc 2220
cgtccgatgg ggcctcgttc ccacgcgctg acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct 2460
gtcccgctgc tgcgcaggct cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga 2580
cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac 2640
ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg 2700
gccgacgtgg aacagacctg a 2721
<210> 187
<211> 2715
<212> DNA
<213> Streptomyces violaceusniger
<400> 187
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc 60
attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc 120
ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc 180
atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc 300
cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ttagcccgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag 540
ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg 600
gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg 660
tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc 780
agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac 960
ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct 1140
ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc 1200
tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcaat cgagcgccgc 1260
cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc 1380
ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga 1440
gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg 1500
gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc 1680
gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag 1740
ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc 1860
ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg 1980
cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag 2040
tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa 2100
cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc 2160
gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc 2220
cgtccgatgg gacctcgttc ccgcgcatta acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct 2460
gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga 2580
cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac 2640
ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg 2700
gccgacgtgg aatag 2715
<210> 188
<211> 2715
<212> DNA
<213> Streptomyces violaceusniger
<400> 188
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cccgcgagga cgaactcggc 60
attctgcaga ggtctctgga agaagcaggc agcggccagg gcgccgtggt caccgtcacc 120
ggcccgatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgacgcc 180
atcattctgc gcgcggtctg cgcgcccgaa gagcgcgcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg agctggctga tcggatagcc 300
cagggcgggc atctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtcga ccggcctgtg ctgatcggcg tcgacgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ctggcccgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag 540
ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cactcggacc ggagcaatcg 600
gcggagctgg cccacgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg 660
tatgggatga ccaggggcaa cctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gcccaggcca acggagagag cgctttcgag gtgggccgcg cgttccggct ggcgtacctc 780
agctcgctct accgctgtgg cccgatcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccaagcg ccaccaccac gctggtgcgc cgtctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct cactgagggc gggctgctgc tcgaccacca gttcccgcac 960
ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cagcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatat tcgccagggc tggccaggct 1140
ctggttgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgagcc 1200
tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcaat cgagcgccgc 1260
cgcaatccgc tggcctccag tcgtcacatg gacgagctga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc agcgctggct gtcttctggc tggccgacgg cgggcgatcc 1380
ggcgaggcag ccgaggtgct ggcgtcggaa cacccgctcg cgaccaccga tcagaaccga 1440
gcacacctgc gatttgccga ggtgactctc gcgctgttct gtcccggcgc cttcgggtcg 1500
gaccggcgcc cacctccgct ggcgccggac gagctcgcca gcttgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggtcatg acagcgttgc atgctcatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc aatccccgcc 1680
gcactgatcg ccctgttgta cgcagagaac accgagtccg ctcagatctg ggccgacaag 1740
ctgggcagca ccaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tggcaccgtc 1860
ctggacgacc ggccgctgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggcagccg ctgtccgcct gggcgaactc gagcgtgcgg agaagctgct cgctgagccg 1980
cttccgaacg gtgtccagga cagccttttc ggtctgcacc tgctctcggc gcacggccag 2040
tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcacac ctgcggagaa 2100
cgtatgcgca gctggggtgt tgacgtgcct ggtctagccc tgtggcgtgt cgacgccgcc 2160
gaggcactgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcgcc 2220
cgtccgatgg gacctcgttc ccgcgcactg acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcagctgagc tgctgctctc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct 2460
gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgt cggccctggc cgcggccgga 2580
cagaccaacc gggagatcgc caaacagcta ttcgtcacgg ccagcaccgt ggaacagcac 2640
ctcacaagcg tcttccgcaa gctgggcgtt aagggccgca ggcagctacc gaccgcgctg 2700
gccgacgtgg aatag 2715
<210> 189
<211> 2721
<212> DNA
<213> Streptomyces Sp. NRRL F-4729
<400> 189
gtgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc 60
attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc 120
ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc 180
atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc 300
cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag 540
ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg 600
gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg 660
tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc 780
agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac 960
ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct 1140
ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc 1200
tccgacgatg tctccacccg ggccgcctta cgggtcgagg ccgtggcgat cgagcgccgc 1260
cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc 1380
ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg 1440
gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg 1500
gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc 1680
gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag 1740
ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc 1860
ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg 1980
cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag 2040
tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa 2100
cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc 2160
gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc 2220
cgtccgatgg gacctcgttc ccgcgcgtta acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct 2460
gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga 2580
cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac 2640
ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg 2700
gccgacgtgg aacagacctg a 2721
<210> 190
<211> 2721
<212> DNA
<213> Streptomyces Sp. NRRL F-4729
<400> 190
atgtatagcg gtacctgccg tgaaggatac gaactcgtcg cacgcgagga cgaactcggc 60
attctacaga ggtctctgga acaagcgagc agcggccagg gcgtcgtggt caccgtcacc 120
ggcccaatcg cctgcggcaa gacagaactg cttgacgcgg ctgccgcgaa ggctgaggcc 180
atcattctgc gcgcggtctg cgcgcccgaa gagcgggcta tgccgtacgc catgatcggg 240
cagctcatcg acgacccggc gctcgcgcat cgggcgccgg ggctggctga tcggatagcc 300
cagggcgggc agctgtcgct gagggccgag aaccgactgc gcagggatct cacccgtgcc 360
ctgctggcgc ttgccgtgca ccggcctgtg ctgatcggcg tcgatgatgt gcatcacgcc 420
gacaccgcct ctttgaactg tctgctgcat ttggcgcgcc gggtccgtcc ggcccggata 480
tccatgatct tcaccgagtt gcgcagcctc acccctactc agtcacgatt caaggcggag 540
ctgctcagcc tgccgtacca ccacgagatc gcgctgcgtc cattcggacc ggagcaatcg 600
gcggagctgg ctcgcgccgc cttcggcccg ggcctcgccg aggatgtgct cgcggggttg 660
tataaaacga ccaggggcaa tctgagtctc agccgtggac tgatcagcga tgtgcgggag 720
gccctggcca acggagagag cgctttcgag gcgggccgcg cgttccggct ggcgtacctc 780
agctcgctct accgctgtgg cccggtcgcg ctgcgggtcg cccgagtggc tgccgtgctg 840
ggcccaagcg ccaccaccac gctggtgcgc cggctaagcg ggctcagcgc ggagacgata 900
gaccgggcaa ccaagatcct caccgagggc gggctgctgc tcgaccagca gtttccgcac 960
ccggccgccc gctcggtggt gctcgatgac atgtccgccc aggaacgacg cggcctgcac 1020
actctcgccc tggaactgct ggacgaggcg ccggttgaag tgctcgcgca ccaccaggtc 1080
ggcgccggtc tcatacacgg gcccaaggct gcggagatgt tcgccaaggc cggcaaggct 1140
ctggtcgtac gcaacgagtt gggcgacgcg gccgaatacc tgcaactggc tcaccgggcc 1200
tccgacgatg tctccacccg ggccgccctg cgggtcgagg ccgtggcgat cgagcgccgc 1260
cgcaatccgc tggcctccag tcggcacatg gacgagctga gcgccgccgg ccgcgccggt 1320
ctgctttccc ccaagcatgc ggcgctggcc gtcttctggc tggccgacgg cgggcgatcc 1380
ggcgaggcag cccaggtgct ggcgtcggaa cgcccgctcg cgaccaccga tcagaaccgg 1440
gcccacctgc gatttgtcga ggtgactctc gcgctgttct ctcccggcgc cttcggatcg 1500
gaccggcgcc cacctccgct gacgccggac gaactcgcca gcctgccgaa ggcggcctgg 1560
caatgcgcgg tcgccgacaa cgcggccatg accgccttgc acggccatcc agaacttgcc 1620
accgctcagg cggaaacagt tctgcggcag gctgattcgg cagccgacgc gatccccgcc 1680
gcgctgatcg ccctgttgta cgcggagaac accgagtccg ctcatatctg ggccgacaag 1740
ctgggcagca tgaatgccgg ggtatcgaac gaggcggaag cgggctacgc cggcccgtgc 1800
gccgagatcg ccctgcggcg cggcgacctg gccacggcgt tcgaggctgg tagcaccgtc 1860
ctggacgacc ggtcactgcc gtcgctcggc atcaccgccg cattgctgtt gagcagcaag 1920
acggccgccg ctgtccggct gggcgaactc gagcgtgcgg agaagctgct cgccgagccg 1980
cttccgaacg gcgtccagga cagccttttc ggtctgcacc tgctctcggc gtacggccag 2040
tacagcctcg cgatgggccg atatgaatcg gctcaccggg cgtttcgcac ctgcggagaa 2100
cgtatgcgca gctgggatgt tgacgtgcct ggtctggccc tgtggcgtgt cgacgccgcc 2160
gaggcgctgc tcagcctcga ccggaacgag ggccagcggc tcatcgacga acaactcacc 2220
cgtccgatgg gacctcgttc ccgcgcgctg acgctgcgga tcaaggcggc atacctcccg 2280
cggacgaagc ggatccccct gctccatgag gcggccgagc tgctgctccc ctgccccgac 2340
ccgtacgagc aagcgcgggt gctcgccgat ctgggcgaca cgctcagcgc gctcagacgc 2400
tatagccggg cgcggggagt tctccggcag gctcgtcacc tggccaccca gtgcggtgct 2460
gtcccgctgc tgcgccgact cgggggcgag cccggccgga tcgacgacgc cggcctgccg 2520
cagcggagca catcgttgac cgatgcggag cggcgggtgg cggcgctggc cgcggccgga 2580
cagaccaacc gggagatcgc cgaacagctg ttcgtcacgg ccagcacagt ggaacagcac 2640
ctcacaagcg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc gaccgcgctg 2700
gccgacgtgg aacagacctg a 2721
<210> 191
<211> 2715
<212> DNA
<213> Streptomyces filamentosus
<400> 191
gtgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg 60
ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt 120
accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac 180
gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc 240
gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc 300
gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt 360
gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac 420
gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga 480
atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagttacg gttcaacgcg 540
gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat 600
gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag 660
ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg 720
gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac 780
ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta 840
ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc 900
atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca 960
catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg 1020
cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg 1080
gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg 1140
gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg 1200
gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc 1260
cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc 1320
ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg 1380
cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac 1440
cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc 1500
tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc 1560
agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt 1620
gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc 1680
accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac 1740
aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc 1800
gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc 1860
ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg 1920
gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg 1980
ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag 2040
tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa 2100
cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc 2160
gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc 2220
cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg 2280
gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac 2340
cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac 2400
taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg 2460
gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag 2520
ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga 2580
ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac 2640
ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg 2700
gacgacatgg aatag 2715
<210> 192
<211> 2715
<212> DNA
<213> Streptomyces filamentosus
<400> 192
atgcgagcta ttaatgcgtc cgacaccggt cctgaactgg tcgcccgcga agacgaactg 60
ggacgtgtac gaagtgccct gaaccgagcg aacggcggcc aaggtgtcct gatctccatt 120
accggtccga tcgcctgcgg caagaccgaa ctgcttgagg ctgccgcctc ggaagttgac 180
gccatcactc tgcgcgcggt ctgtgccgcc gaggaacggg cgatacctta tgccctgatc 240
gggcagctta tcgacaaccc cgcgctcggc attccggttc cggatccggc cggcctgacc 300
gcccagggcg gacgactgtc atcgagcgcc gagaaccgac tgcgtcgcga cctcacccgt 360
gccctgctga cgctcgccac cgaccggctg gtgctgatct gtgtcgatga cgtgcagcac 420
gccgacaacg cctcgttgag ctgccttctg tatctggccc gacggcttgt cccggctcga 480
atcgctctgg tattcaccga gttgcgagtc ctcacctcgt ctcagctgcg gttcaacgcg 540
gagctgctca gcttgcggaa ccactgcgag atcgcgctgc gcccactcgg cccggggcat 600
gcggccgagc tggcccgcgc caccctcggc cccggcctct ccgacgaaac actcacggag 660
ctgtaccggg tgaccggagg caacctgagt ctcagccgcg ggctgatcga cgatgtgcgg 720
gacgcctggg cacgagggga aacgggcgtc caggtgggcc gggcgttccg gctggcctac 780
ctcggttccc tccaccgctg tggtccgctg gcgttgcggg tcgcccgcgt agccgccgta 840
ctgggcccga gcgccaccag cgtcctggtg cgccggatca gtgggctcag cgcggaggcc 900
atggcccagg cgaccgatat cctcgctgac ggcggcctcc tgcgcgacca gcggttcaca 960
catccagcgg cccgctcggt ggtgctcgac gacatgtccg ccgaggaacg acgcagcgtg 1020
cacagcctcg ccctggaact gctggacgag gcaccggccg agatgctcgc gcaccaccgg 1080
gtcggcgccg gtctcgtgca cgggccgaag gccgcggaga cattcaccgg ggccggccgg 1140
gcactggccg ttcgcggcat gctgggcgag gcagccgact acctgcaact ggcgtaccgg 1200
gcctccggcg acgccgctac caaggccgcg atacgcgtcg agtccgtggc ggtcgagcgc 1260
cgacgcaatc cgctggtcgt cagtcgccat tgggacgagc tgagcgtcgc ggcccgcgcc 1320
ggtctgctct cctgcgagca cgtgtccagg acggcccgct ggctgaccgt cggtgggcgg 1380
cccggcgagg cggccagggt gctggcgtcg caacaccgac gggtcgtcac cgatcaggac 1440
cgggcccacc tgcgggtcgc cgagttctcg ctcgcgctgc tgtaccccgg tacgtccggc 1500
tcggaccggc gcccgcaccc gctcacgtcg gacgaactcg cggccctacc gactgcgacc 1560
agacactgcg cgatcgccga taacgctgtc atggctgcct tgcgtggtca tccggagctt 1620
gccaccgccg aggcagaagc cgttctgcag caagccgacg cggcggacgg cgctgctctc 1680
accgcgctga tggccctgct gtacgcggag agcatcgagg tcgctgaagt ctgggcggac 1740
aagctggcgg cagaggccgg agcatcgaac gggcaggacg cggagtacgc cggtatacgc 1800
gccgaaatcg ccctgcggcg cggcgatctg accgcggccg tcgagaccgc cggcatggtc 1860
ctggacggcc ggccgctgcc gtcgctcgac atcaccgcca cgttgctgtt ggccggcagg 1920
gcgtccgtcg ccgtccggct gggcgaactc gaccacgcgg aggagctgtt cgccgcgccg 1980
ccggaggacg ccttccagga cagcctcttc ggtctgcatc tgctctcggc gcacggccag 2040
tacagcctcg cgacaggccg gcccgagtcg gcataccggg cctttcgtgc ctgcggcgaa 2100
cgtatgcgcg attggggctt cgacgcgccc ggtgtggccc tgtggcgcgt cggcgccgcc 2160
gaggcgctgc tcggcctcga ccggaacgag ggccgacggc tcatcgacga acagctgagc 2220
cggacgatgg ccccccggtc ccacgcgttg acgctgcgga taaaagcggc gtacatgccg 2280
gagccgaagc gggtcgacct gctctacgaa gcggctgagc tgctgctctc ctgccgggac 2340
cagtatgagc gagcgcgggt gctcgccgat ctgggcgagg cgctcagcgc gctcgggaac 2400
taccggcagg cgcgaggtgt gctccggcag gctcggcatc tggccatgcg aaccggcgcg 2460
gacccgctgc tgcgccggct cggaatcagg cccggccggc aggacgaccc cgacccgcag 2520
ccgcggagca gatcgctgac caacgctgag cggcgtgcgg cgtcgctggc cgcgaccgga 2580
ctgaccaacc gggagatcgc cgaccggctc ttcgtcaccg ccagcaccgt ggagcagcac 2640
ctcaccaacg tcttccgcaa gctgggcgtc aagggccgca agcagctgcc ggccgagttg 2700
gacgacatgg aatag 2715
<210> 193
<211> 894
<212> PRT
<213> Streptomyces hygroscopicus
<400> 193
Met Pro Ala Val Glu Cys Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu
1 5 10 15
Arg Lys Leu Glu Glu Val Val Thr Gly Arg Ala Asn Gly Arg Gly Val
20 25 30
Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu
35 40 45
Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Thr Leu Arg Ala Val Cys
50 55 60
Ser Ala Glu Glu Gln Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile
65 70 75 80
Asp Asn Pro Ala Leu Ala Ser His Ala Leu Glu Pro Ala Cys Pro Thr
85 90 95
Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Ser
100 105 110
Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu
115 120 125
Ile Gly Ile Asp Glu Ser His Ala Asn Ala Leu Cys Leu Leu His Leu
130 135 140
Ala Arg Arg Val Gly Ser Ala Arg Ile Ala Met Val Leu Thr Glu Leu
145 150 155 160
Arg Arg Leu Thr Pro Ala His Ser Gln Phe Gln Ala Glu Leu Leu Ser
165 170 175
Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu Ser Pro Lys His
180 185 190
Thr Ala Glu Leu Val Arg Ala Gly Leu Gly Pro Asp Val Asp Glu Asp
195 200 205
Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn Leu Asn Leu Thr
210 215 220
Arg Gly Leu Ile Asn Asp Val Arg Glu Ala Trp Glu Thr Gly Gly Thr
225 230 235 240
Gly Ile Ser Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Gly Ser Leu
245 250 255
Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg Val Ala Ala Val
260 265 270
Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp Ile Ser Gly Leu
275 280 285
Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu Thr Glu Gly Gly
290 295 300
Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala Arg Ser Val Val
305 310 315 320
Leu Asn Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser Ala
325 330 335
Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val Ala His His Gln
340 345 350
Val Gly Ala Gly Leu Leu His Gly Pro Lys Ala Ala Glu Ile Phe Ala
355 360 365
Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu Asp Thr Ala Ser
370 375 380
Asp Tyr Leu Gln Leu Ala His Gln Ala Ser Asp Asp Ala Val Thr Gly
385 390 395 400
Met Arg Ala Glu Ala Val Ala Ile Glu Arg Arg Arg Asn Pro Leu Ala
405 410 415
Ser Ser Arg His Leu Asp Glu Leu Thr Val Val Ala Arg Ala Gly Leu
420 425 430
Leu Phe Pro Glu His Thr Ala Leu Met Ile Arg Trp Leu Gly Val Gly
435 440 445
Gly Arg Ser Gly Glu Ala Ala Gly Leu Leu Ala Ser Gln Arg Pro Arg
450 455 460
Ala Val Thr Asp Gln Asp Arg Ala His Met Arg Ala Ala Glu Val Ser
465 470 475 480
Leu Ala Leu Val Ser Pro Gly Thr Ser Gly Pro Asp Arg Arg Pro Arg
485 490 495
Pro Leu Thr Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu
500 505 510
Cys Ala Ile Ala Asp Asn Ala Val Met Ser Ala Leu Arg Gly Arg Pro
515 520 525
Glu Leu Ala Ala Ala Glu Ala Glu Asn Val Leu Gln His Ala Asp Ser
530 535 540
Ala Ala Ala Gly Thr Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu Tyr
545 550 555 560
Ala Glu Asn Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser
565 570 575
Glu Thr Gly Ala Ser Asn Glu Glu Glu Ala Gly Tyr Ala Gly Pro Arg
580 585 590
Ala Glu Ala Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala
595 600 605
Gly Ser Thr Val Leu Asp His Arg Arg Leu Ser Thr Leu Gly Ile Thr
610 615 620
Ala Ala Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly
625 630 635 640
Glu Thr Glu Arg Ala Glu Lys Trp Leu Ala Gln Pro Leu Pro Gln Ala
645 650 655
Ile Gln Asp Gly Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln
660 665 670
Tyr Ser Leu Ala Thr Gly Gln His Glu Ser Ala Tyr Thr Ala Phe Arg
675 680 685
Thr Cys Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu
690 695 700
Ser Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp
705 710 715 720
Arg Asp Glu Gly Arg Arg Leu Val Asp Glu Gln Leu Thr Arg Ala Met
725 730 735
Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser
740 745 750
Pro Pro Ala Lys Arg Val Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu
755 760 765
Leu Ser Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu
770 775 780
Ser Glu Thr Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu
785 790 795 800
Leu Arg Gln Ala Arg His Leu Ala Ala Gln Arg Gly Ala Ile Pro Leu
805 810 815
Leu Arg Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu
820 825 830
Ser Gly Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg
835 840 845
Val Ala Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp
850 855 860
Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asp Val
865 870 875 880
Ser Thr Gly Ser Arg Pro Pro Ala Pro Ala Ala Glu Leu Val
885 890
<210> 194
<211> 923
<212> PRT
<213> Streptomyces kanamyceticus
<400> 194
Met Val Pro Glu Val Arg Ala Ala Pro Asp Glu Leu Ile Ala Arg Asp
1 5 10 15
Asp Glu Leu Ser Arg Leu Gln Arg Ala Leu Thr Arg Ala Gly Ser Gly
20 25 30
Arg Gly Gly Val Val Ala Ile Thr Gly Pro Ile Ala Ser Gly Lys Thr
35 40 45
Ala Leu Leu Asp Ala Gly Ala Ala Lys Ser Gly Phe Val Ala Leu Arg
50 55 60
Ala Val Cys Ser Trp Glu Glu Arg Thr Leu Pro Tyr Gly Met Leu Gly
65 70 75 80
Gln Leu Phe Asp His Pro Glu Leu Ala Ala Gln Ala Pro Asp Leu Ala
85 90 95
His Phe Thr Ala Ser Cys Glu Ser Pro Gln Ala Gly Thr Asp Asn Arg
100 105 110
Leu Arg Ala Glu Phe Thr Arg Thr Leu Leu Ala Leu Ala Ala Asp Trp
115 120 125
Pro Val Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Glu Ser
130 135 140
Leu Arg Cys Leu Leu His Leu Ala Arg Arg Ile Gly Pro Ala Arg Ile
145 150 155 160
Ala Val Val Leu Thr Glu Leu Arg Arg Pro Thr Pro Ala Asp Ser Arg
165 170 175
Phe Gln Ala Glu Leu Leu Ser Leu Arg Ser Tyr Gln Glu Ile Ala Leu
180 185 190
Arg Pro Leu Thr Glu Ala Gln Thr Gly Glu Leu Val Arg Arg His Leu
195 200 205
Gly Ala Glu Thr His Glu Asp Val Ser Ala Asp Thr Phe Arg Ala Thr
210 215 220
Gly Gly Asn Leu Leu Leu Gly His Gly Leu Ile Asn Asp Ile Arg Glu
225 230 235 240
Ala Arg Thr Ala Gly Arg Pro Gly Val Val Ala Gly Arg Ala Tyr Arg
245 250 255
Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ser Ala Leu Arg
260 265 270
Val Ala Arg Ala Ser Ala Val Leu Gly Ala Ser Ala Glu Ala Val Leu
275 280 285
Val Gln Arg Met Thr Gly Leu Asn Lys Asp Ala Val Glu Gln Val Tyr
290 295 300
Glu Gln Leu Asn Glu Gly Arg Leu Leu Gln Gly Glu Arg Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Ile Val Leu Asp Asp Leu Ser Ala Leu Glu Arg
325 330 335
Arg Asn Leu His Glu Ser Ala Leu Glu Leu Leu Arg Asp His Gly Val
340 345 350
Ala Gly Asn Val Leu Ala Arg His Gln Ile Gly Ala Gly Arg Val His
355 360 365
Gly Glu Glu Ala Val Glu Leu Phe Thr Gly Ala Ala Arg Glu His His
370 375 380
Leu Arg Gly Glu Leu Asp Asp Ala Ala Gly Tyr Leu Glu Leu Ala His
385 390 395 400
Arg Ala Ser Asp Asp Pro Val Thr Arg Ala Ala Leu Arg Val Gly Ala
405 410 415
Ala Ala Ile Glu Arg Leu Cys Asn Pro Val Arg Ala Gly Arg His Leu
420 425 430
Pro Glu Leu Leu Thr Ala Ser Arg Ala Gly Leu Leu Ser Ser Glu His
435 440 445
Ala Val Ser Leu Ala Asp Trp Leu Ala Met Gly Gly Arg Pro Gly Glu
450 455 460
Ala Ala Glu Val Leu Ala Thr Gln Arg Pro Ala Ala Asp Ser Glu Gln
465 470 475 480
His Arg Ala Leu Leu Arg Ser Gly Glu Leu Ser Leu Ala Leu Val His
485 490 495
Pro Gly Ala Trp Asp Pro Leu Arg Arg Thr Asp Arg Phe Ala Ala Gly
500 505 510
Gly Leu Gly Ser Leu Pro Gly Pro Ala Arg His Arg Ala Val Ala Asp
515 520 525
Gln Ala Val Ile Ala Ala Leu Arg Gly Arg Leu Asp Arg Ala Asp Ala
530 535 540
Asn Ala Glu Ser Val Leu Gln His Thr Asp Ala Thr Ala Asp Arg Thr
545 550 555 560
Thr Ala Ile Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asn Thr Asp
565 570 575
Ala Val Gln Phe Trp Val Asp Lys Leu Ala Gly Asp Glu Gly Thr Arg
580 585 590
Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Asn Ala Glu Ile Ala
595 600 605
Leu Arg Arg Gly Asp Leu Met Arg Ala Val Glu Tyr Gly Glu Ala Ala
610 615 620
Leu Gly His Arg His Leu Pro Thr Trp Gly Met Ala Ala Ala Leu Pro
625 630 635 640
Leu Ser Ser Thr Val Val Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg
645 650 655
Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Gln Gln Thr Pro Glu Ser
660 665 670
Leu Phe Gly Leu His Leu Leu Trp Ala Arg Gly Gln His His Leu Ala
675 680 685
Thr Gly Arg His Gly Ala Ala Tyr Thr Ala Phe Arg Glu Cys Gly Glu
690 695 700
Arg Met Arg Arg Trp Ala Val Asp Val Pro Gly Leu Ala Leu Trp Arg
705 710 715 720
Val Asp Ala Ala Glu Ser Leu Leu Leu Leu Gly Arg Asp Arg Ala Glu
725 730 735
Gly Leu Arg Leu Val Ser Glu Gln Leu Ser Arg Pro Met Arg Pro Arg
740 745 750
Ala Arg Val Gln Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Pro
755 760 765
Gln Arg Ile Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Val Thr Cys
770 775 780
Asn Asp Gln Tyr Glu Leu Ala Asn Val Leu Ser Asp Leu Ala Glu Ala
785 790 795 800
Ser Ser Met Val Arg Gln His Ser Arg Ala Arg Gly Leu Leu Arg Arg
805 810 815
Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg
820 825 830
Leu Gly Ala Glu Pro Ser Asp Ile Gly Gly Ala Trp Asp Ala Thr Leu
835 840 845
Gly Gln Arg Ile Ala Ser Leu Thr Glu Ser Glu Arg Arg Val Ala Ala
850 855 860
Leu Ala Ala Val Gly Arg Thr Asn Arg Glu Ile Ala Glu Gln Leu Phe
865 870 875 880
Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys
885 890 895
Leu Ala Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ala Asp Val
900 905 910
Gly Glu Pro Ala Asp Arg Asp Arg Arg Cys Gly
915 920
<210> 195
<211> 913
<212> PRT
<213> Streptomyces ascomyceticus
<400> 195
Met Ile Ala Arg Leu Ser Pro Pro Asp Leu Ile Ala Arg Asp Asp Glu
1 5 10 15
Phe Gly Ser Leu His Arg Ala Leu Thr Arg Ala Gly Gly Gly Arg Gly
20 25 30
Val Val Ala Ala Val Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu
35 40 45
Leu Asp Ala Ala Ala Ala Lys Ala Gly Phe Val Thr Leu Arg Ala Val
50 55 60
Cys Ser Met Glu Glu Arg Ala Leu Pro Tyr Gly Met Leu Gly Gln Leu
65 70 75 80
Leu Asp Gln Pro Glu Leu Ala Ala Arg Thr Pro Glu Leu Val Arg Leu
85 90 95
Thr Ala Ser Cys Glu Asn Leu Pro Ala Asp Val Asp Asn Arg Leu Gly
100 105 110
Thr Glu Leu Thr Arg Thr Val Leu Thr Leu Ala Ala Glu Arg Pro Val
115 120 125
Leu Ile Gly Ile Asp Asp Val His His Ala Asp Ala Pro Ser Leu Arg
130 135 140
Cys Leu Leu His Leu Ala Arg Arg Ile Ser Arg Ala Arg Val Ala Ile
145 150 155 160
Val Leu Thr Glu Leu Leu Arg Pro Thr Pro Ala His Ser Gln Phe Arg
165 170 175
Ala Ala Leu Leu Ser Leu Arg His Tyr Gln Glu Ile Ala Leu Arg Pro
180 185 190
Leu Thr Glu Ala Gln Thr Thr Glu Leu Val Arg Arg His Leu Gly Gln
195 200 205
Asp Ala His Asp Asp Val Val Ala Gln Ala Phe Arg Ala Thr Gly Gly
210 215 220
Asn Leu Leu Leu Gly His Gly Leu Ile Asp Asp Ile Arg Glu Ala Arg
225 230 235 240
Thr Arg Thr Ser Gly Cys Leu Glu Val Val Ala Gly Arg Ala Tyr Arg
245 250 255
Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Ser
260 265 270
Val Ala Arg Ala Ser Ala Val Leu Gly Glu Ser Val Glu Leu Thr Leu
275 280 285
Val Gln Arg Met Thr Gly Leu Asp Thr Glu Ala Val Glu Gln Ala His
290 295 300
Glu Gln Leu Val Glu Gly Arg Leu Leu Arg Glu Gly Arg Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Val Val Leu Asp Asp Leu Ser Ala Ala Glu Arg
325 330 335
Arg Gly Leu His Glu Leu Ala Leu Glu Leu Leu Arg Asp Arg Gly Val
340 345 350
Ala Ser Lys Val Leu Ala Arg His Gln Met Gly Thr Gly Arg Val His
355 360 365
Gly Ala Glu Val Ala Gly Leu Phe Thr Asp Ala Ala Arg Glu His His
370 375 380
Leu Arg Gly Glu Leu Asp Glu Ala Val Thr Tyr Leu Glu Phe Ala Tyr
385 390 395 400
Arg Ala Ser Asp Asp Pro Ala Val His Ala Ala Leu Arg Val Asp Thr
405 410 415
Ala Ala Ile Glu Arg Leu Cys Asp Pro Ala Arg Ser Gly Arg His Val
420 425 430
Pro Glu Leu Leu Thr Ala Ser Arg Glu Arg Leu Leu Ser Ser Glu His
435 440 445
Ala Val Ser Leu Ala Cys Trp Leu Ala Met Asp Gly Arg Pro Gly Glu
450 455 460
Ala Ala Glu Val Leu Ala Ala Gln Arg Ser Ala Ala Pro Ser Glu Gln
465 470 475 480
Gly Arg Ala His Leu Arg Val Ala Asp Leu Ser Leu Ala Leu Ile Tyr
485 490 495
Pro Gly Ala Ala Asp Pro Pro Arg Pro Ala Asp Pro Pro Ala Glu Asp
500 505 510
Glu Val Ala Ser Phe Ser Gly Ala Val Arg His Arg Ala Val Ala Asp
515 520 525
Lys Ala Leu Ser Asn Ala Leu Arg Gly Trp Ser Glu Gln Ala Glu Ala
530 535 540
Lys Ala Glu Tyr Val Leu Gln His Ser Arg Val Thr Thr Asp Arg Thr
545 550 555 560
Thr Thr Met Met Ala Leu Leu Ala Leu Leu Tyr Ala Glu Asp Thr Asp
565 570 575
Ala Val Gln Ser Trp Val Asp Lys Leu Ala Gly Asp Asp Asn Met Arg
580 585 590
Thr Pro Ala Asp Glu Ala Val His Ala Gly Phe Arg Ala Glu Ala Ala
595 600 605
Leu Arg Arg Gly Asp Leu Thr Ala Ala Val Glu Cys Gly Glu Ala Ala
610 615 620
Leu Ala Pro Arg Val Val Pro Ser Trp Gly Met Ala Ala Ala Leu Pro
625 630 635 640
Leu Ser Ser Thr Val Ala Ala Ala Ile Arg Leu Gly Asp Leu Asp Arg
645 650 655
Ala Glu Arg Trp Leu Ala Glu Pro Leu Pro Glu Glu Thr Ser Asp Ser
660 665 670
Leu Phe Gly Leu His Met Val Trp Ala Arg Gly Gln His His Leu Ala
675 680 685
Ala Gly Arg Tyr Arg Ala Ala Tyr Asn Ala Phe Arg Asp Cys Gly Glu
690 695 700
Arg Met Arg Arg Trp Ser Val Asp Val Pro Gly Leu Ala Leu Trp Arg
705 710 715 720
Val Asp Ala Ala Glu Ala Leu Leu Leu Leu Gly Arg Gly Arg Asp Glu
725 730 735
Gly Leu Arg Leu Ile Ser Glu Gln Leu Ser Arg Pro Met Gly Ser Arg
740 745 750
Ala Arg Val Met Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Pro Ala
755 760 765
Lys Arg Ile Glu Leu Leu Asp Glu Ala Ala Asp Leu Leu Ile Met Cys
770 775 780
Arg Asp Gln Tyr Glu Leu Ala Arg Val Leu Ala Asp Met Gly Glu Ala
785 790 795 800
Cys Gly Met Leu Arg Arg His Ser Arg Ala Arg Gly Leu Phe Arg Arg
805 810 815
Ala Arg His Leu Ala Thr Gln Cys Gly Ala Val Pro Leu Leu Arg Arg
820 825 830
Leu Gly Gly Glu Ser Ser Asp Ala Asp Gly Thr Gln Asp Val Thr Pro
835 840 845
Ala Gln Arg Ile Thr Ser Leu Thr Glu Ala Glu Arg Arg Val Ala Ser
850 855 860
His Ala Ala Val Gly Arg Thr Asn Lys Glu Ile Ala Ser Gln Leu Phe
865 870 875 880
Val Thr Ser Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg Lys
885 890 895
Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Lys Glu Leu Ser Asp Ala
900 905 910
Gly
<210> 196
<211> 901
<212> PRT
<213> Micromonospora sp. S92-306401
<400> 196
Met Glu Phe Tyr Asp Leu Val Ala Arg Asp Asp Glu Leu Arg Arg Leu
1 5 10 15
Asp Gln Ala Leu Gly Arg Ala Ala Gly Gly Arg Gly Val Val Val Thr
20 25 30
Val Thr Gly Pro Val Gly Cys Gly Lys Thr Glu Leu Leu Asp Ala Ala
35 40 45
Ala Ala Glu Glu Glu Phe Ile Thr Leu Arg Ala Val Cys Ser Ala Glu
50 55 60
Glu Arg Ala Leu Pro Tyr Ala Val Ile Gly Gln Leu Leu Asp His Pro
65 70 75 80
Val Leu Ser Ala Arg Ala Pro Asp Leu Ala Cys Val Thr Ala Pro Gly
85 90 95
Arg Thr Leu Pro Ala Asp Thr Glu Asn Arg Leu Arg Arg Asp Leu Thr
100 105 110
Arg Ala Leu Leu Ala Leu Ala Ser Glu Arg Pro Val Leu Ile Cys Ile
115 120 125
Asp Asp Val His Gln Ala Asp Thr Ala Ser Leu Asn Cys Leu Leu His
130 135 140
Leu Ala Arg Arg Val Ala Ser Ala Arg Ile Ala Met Ile Leu Thr Glu
145 150 155 160
Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Glu Ala Glu Leu Leu
165 170 175
Ser Leu Arg His Arg His Glu Ile Ala Leu Arg Pro Leu Gly Pro Ala
180 185 190
Asp Thr Ala Glu Leu Ala Arg Ala Arg Leu Gly Ala Gly Val Thr Ala
195 200 205
Asp Glu Leu Ala Gln Val His Glu Ala Thr Ser Gly Asn Pro Asn Leu
210 215 220
Val Gly Gly Leu Val Asn Asp Val Arg Glu Ala Trp Ala Ala Gly Gly
225 230 235 240
Thr Gly Ile Ala Ala Gly Arg Ala Tyr Arg Leu Ala Tyr Leu Ser Ser
245 250 255
Val Tyr Arg Cys Gly Pro Val Pro Leu Arg Ile Ala Gln Ala Ala Ala
260 265 270
Val Leu Gly Pro Ser Ala Thr Val Thr Leu Val Arg Arg Ile Ser Gly
275 280 285
Leu Asp Ala Glu Thr Val Asp Glu Ala Thr Ala Ile Leu Thr Glu Gly
290 295 300
Gly Leu Leu Arg Asp His Arg Phe Pro His Pro Ala Ala Arg Ser Val
305 310 315 320
Val Leu Asp Asp Met Ser Ala Gln Glu Arg Arg Arg Leu His Arg Ser
325 330 335
Thr Leu Asp Val Leu Asp Gly Val Pro Val Asp Val Leu Ala His His
340 345 350
Gln Ala Gly Ala Gly Leu Leu His Gly Pro Gln Ala Ala Glu Met Phe
355 360 365
Ala Arg Ala Ser Gln Glu Leu Arg Val Arg Gly Glu Leu Asp Ala Ala
370 375 380
Thr Glu Tyr Leu Gln Leu Ala Tyr Arg Ala Ser Asp Asp Ala Gly Ala
385 390 395 400
Arg Ala Ala Leu Gln Val Glu Thr Val Ala Gly Glu Arg Arg Arg Asn
405 410 415
Pro Leu Ala Ala Ser Arg His Leu Asp Glu Leu Ala Ala Ala Ala Arg
420 425 430
Ala Gly Leu Leu Ser Ala Glu His Ala Ala Leu Val Val His Trp Leu
435 440 445
Ala Asp Ala Gly Arg Pro Gly Glu Ala Ala Glu Val Leu Ala Leu Gln
450 455 460
Arg Ala Leu Ala Val Thr Asp His Asp Arg Ala Arg Leu Arg Ala Ala
465 470 475 480
Glu Val Ser Leu Ala Leu Phe His Pro Gly Val Pro Gly Ser Asp Pro
485 490 495
Arg Pro Leu Ala Pro Glu Glu Leu Ala Ser Leu Ser Leu Ser Ala Arg
500 505 510
His Gly Val Thr Ala Asp Asn Ala Val Leu Ala Ala Leu Arg Gly Arg
515 520 525
Pro Glu Ser Ala Ala Ala Glu Ala Glu Asn Val Leu Arg Asn Ala Asp
530 535 540
Ala Ala Ala Ser Gly Pro Thr Ala Leu Ala Ala Leu Thr Ala Leu Leu
545 550 555 560
Tyr Ala Glu Asn Thr Asp Ala Ala Gln Leu Trp Ala Asp Lys Leu Ala
565 570 575
Ala Gly Ile Gly Ala Gly Glu Gly Glu Ala Gly Tyr Ala Gly Pro Arg
580 585 590
Thr Val Ala Ala Leu Arg Arg Gly Asp Leu Thr Thr Ala Val Gln Ala
595 600 605
Ala Gly Ala Val Leu Asp Arg Gly Arg Pro Ser Ser Leu Gly Ile Thr
610 615 620
Ala Val Leu Pro Leu Ser Gly Ala Val Ala Ala Ala Ile Arg Leu Gly
625 630 635 640
Glu Leu Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala
645 650 655
Val His Asp Ser Leu Phe Gly Leu His Leu Leu Met Ala Arg Gly Arg
660 665 670
Tyr Ser Leu Ala Val Gly Arg His Glu Ala Ala Tyr Ala Ala Phe Arg
675 680 685
Asp Cys Gly Glu Arg Met Arg Arg Trp Asp Val Asp Val Pro Gly Leu
690 695 700
Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu Leu Pro Gly Asp Asp
705 710 715 720
Arg Ala Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr Arg Pro Met
725 730 735
Gly Pro Arg Ser Arg Ala Leu Thr Leu Arg Val Arg Ala Ala Tyr Ala
740 745 750
Pro Pro Ala Lys Arg Ile Asp Leu Leu Asp Glu Ala Ala Asp Leu Leu
755 760 765
Leu Ser Ser Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu
770 775 780
Ser Glu Ala Phe Ser Ala Leu Arg Gln Asn Gly Arg Ala Arg Gly Ile
785 790 795 800
Leu Arg Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Val Pro Leu
805 810 815
Leu Arg Arg Leu Gly Val Lys Ala Gly Arg Ser Gly Arg Leu Gly Arg
820 825 830
Pro Pro Gln Gly Ile Arg Ser Leu Thr Glu Ala Glu Arg Arg Val Ala
835 840 845
Thr Leu Ala Ala Ala Gly Gln Thr Asn Arg Glu Ile Ala Asp Gln Leu
850 855 860
Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg
865 870 875 880
Lys Leu Gly Val Lys Gly Arg Gln Gln Leu Pro Ala Glu Leu Ala Asp
885 890 895
Leu Arg Pro Pro Gly
900
<210> 197
<211> 906
<212> PRT
<213> Streptomyces violaceusniger
<400> 197
Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu
1 5 10 15
Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly
20 25 30
Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr
35 40 45
Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg
50 55 60
Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly
65 70 75 80
Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala
85 90 95
Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg
100 105 110
Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg
115 120 125
Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser
130 135 140
Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile
145 150 155 160
Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg
165 170 175
Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu
180 185 190
Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe
195 200 205
Gly Pro Gly Leu Ala Glu Asp Val Leu Val Gly Leu Tyr Lys Thr Thr
210 215 220
Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu
225 230 235 240
Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg
245 250 255
Leu Ala Tyr Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg
260 265 270
Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu
275 280 285
Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr
290 295 300
Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg
325 330 335
Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val
340 345 350
Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro
355 360 365
Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg
370 375 380
Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala
385 390 395 400
Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala
405 410 415
Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu
420 425 430
Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala
435 440 445
Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala
450 455 460
Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg
465 470 475 480
Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly
485 490 495
Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu
500 505 510
Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala
515 520 525
Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala
530 535 540
Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala
545 550 555 560
Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile
565 570 575
Trp Ala Asp Lys Leu Gly Ser Thr Asn Gly Gly Val Ser Asn Glu Ala
580 585 590
Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly
595 600 605
Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg
610 615 620
Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys
625 630 635 640
Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu
645 650 655
Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu
660 665 670
His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr
675 680 685
Glu Ser Ala Leu Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser
690 695 700
Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala
705 710 715 720
Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp
725 730 735
Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu
740 745 750
Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu
755 760 765
His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln
770 775 780
Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg
785 790 795 800
Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Ala
805 810 815
Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly
820 825 830
Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp
835 840 845
Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg
850 855 860
Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His
865 870 875 880
Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu
885 890 895
Pro Thr Ala Leu Ala Asp Val Glu Gln Thr
900 905
<210> 198
<211> 914
<212> PRT
<213> Streptomyces hygroscopicus
<400> 198
Met Pro Ala Val Glu Ser Tyr Glu Leu Asp Ala Arg Asp Asp Glu Leu
1 5 10 15
Arg Arg Leu Glu Glu Ala Val Gly Gln Ala Gly Asn Gly Arg Gly Val
20 25 30
Val Val Thr Ile Thr Gly Pro Ile Ala Cys Gly Lys Thr Glu Leu Leu
35 40 45
Asp Ala Ala Ala Ala Lys Ser Asp Ala Ile Thr Leu Arg Ala Val Cys
50 55 60
Ser Glu Glu Glu Arg Ala Leu Pro Tyr Ala Leu Ile Gly Gln Leu Ile
65 70 75 80
Asp Asn Pro Ala Val Ala Ser Gln Leu Pro Asp Pro Val Ser Met Ala
85 90 95
Leu Pro Gly Glu His Leu Ser Pro Glu Ala Glu Asn Arg Leu Arg Gly
100 105 110
Asp Leu Thr Arg Thr Leu Leu Ala Leu Ala Ala Glu Arg Pro Val Leu
115 120 125
Ile Gly Ile Asp Asp Met His His Ala Asp Thr Ala Ser Leu Asn Cys
130 135 140
Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Met Val
145 150 155 160
Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Gln Phe His Ala
165 170 175
Glu Leu Leu Ser Leu Gly His His Arg Glu Ile Ala Leu Arg Pro Leu
180 185 190
Gly Pro Lys His Ile Ala Glu Leu Ala Arg Ala Gly Leu Gly Pro Asp
195 200 205
Val Asp Glu Asp Val Leu Thr Gly Leu Tyr Arg Ala Thr Gly Gly Asn
210 215 220
Leu Asn Leu Gly His Gly Leu Ile Lys Asp Val Arg Glu Ala Trp Ala
225 230 235 240
Thr Gly Gly Thr Gly Ile Asn Ala Gly Arg Ala Tyr Arg Leu Ala Tyr
245 250 255
Leu Gly Ser Leu Tyr Arg Cys Gly Pro Val Pro Leu Arg Val Ala Arg
260 265 270
Val Ala Ala Val Leu Gly Gln Ser Ala Asn Thr Thr Leu Val Arg Trp
275 280 285
Ile Ser Gly Leu Asn Ala Asp Ala Val Gly Glu Ala Thr Glu Ile Leu
290 295 300
Thr Glu Gly Gly Leu Leu His Asp Leu Arg Phe Pro His Pro Ala Ala
305 310 315 320
Arg Ser Val Val Leu Asn Asp Leu Ser Ala Arg Glu Arg Arg Arg Leu
325 330 335
His Arg Ser Ala Leu Glu Val Leu Asp Asp Val Pro Val Glu Val Val
340 345 350
Ala His His Gln Ala Gly Ala Gly Phe Ile His Gly Pro Lys Ala Ala
355 360 365
Glu Ile Phe Ala Lys Ala Gly Gln Glu Leu His Val Arg Gly Glu Leu
370 375 380
Asp Ala Ala Ser Asp Tyr Leu Gln Leu Ala His His Ala Ser Asp Asp
385 390 395 400
Ala Val Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala Ile Glu Arg
405 410 415
Arg Arg Asn Pro Leu Ala Ser Ser Arg His Leu Asp Glu Leu Thr Val
420 425 430
Ala Ala Arg Ala Gly Leu Leu Ser Leu Glu His Ala Ala Leu Met Ile
435 440 445
Arg Trp Leu Ala Leu Gly Gly Arg Ser Gly Glu Ala Ala Glu Val Leu
450 455 460
Ala Ala Gln Arg Pro Arg Ala Val Thr Asp Gln Asp Arg Ala His Leu
465 470 475 480
Arg Ala Ala Glu Val Ser Leu Ala Leu Val Ser Pro Gly Ala Ser Gly
485 490 495
Val Ser Pro Gly Ala Ser Gly Pro Asp Arg Arg Pro Arg Pro Leu Pro
500 505 510
Pro Asp Glu Leu Ala Asn Leu Pro Lys Ala Ala Arg Leu Cys Ala Ile
515 520 525
Ala Asp Asn Ala Val Ile Ser Ala Leu His Gly Arg Pro Glu Leu Ala
530 535 540
Ser Ala Glu Ala Glu Asn Val Leu Lys Gln Ala Asp Ser Ala Ala Asp
545 550 555 560
Gly Ala Thr Ala Leu Ser Ala Leu Thr Ala Leu Leu Tyr Ala Glu Asn
565 570 575
Thr Asp Thr Ala Gln Leu Trp Ala Asp Lys Leu Val Ser Glu Thr Gly
580 585 590
Ala Ser Asn Glu Glu Glu Gly Ala Gly Tyr Ala Gly Pro Arg Ala Glu
595 600 605
Thr Ala Leu Arg Arg Gly Asp Leu Ala Ala Ala Val Glu Ala Gly Ser
610 615 620
Ala Ile Leu Asp His Arg Arg Gly Ser Leu Leu Gly Ile Thr Ala Ala
625 630 635 640
Leu Pro Leu Ser Ser Ala Val Ala Ala Ala Ile Arg Leu Gly Glu Thr
645 650 655
Glu Arg Ala Glu Lys Trp Leu Ala Glu Pro Leu Pro Glu Ala Ile Arg
660 665 670
Asp Ser Leu Phe Gly Leu His Leu Leu Ser Ala Arg Gly Gln Tyr Cys
675 680 685
Leu Ala Thr Gly Arg His Glu Ser Ala Tyr Thr Ala Phe Arg Thr Cys
690 695 700
Gly Glu Arg Met Arg Asn Trp Gly Val Asp Val Pro Gly Leu Ser Leu
705 710 715 720
Trp Arg Val Asp Ala Ala Glu Ala Leu Leu His Gly Arg Asp Arg Asp
725 730 735
Glu Gly Arg Arg Leu Ile Asp Glu Gln Leu Thr His Ala Met Gly Pro
740 745 750
Arg Ser Arg Ala Leu Thr Leu Arg Val Gln Ala Ala Tyr Ser Pro Gln
755 760 765
Ala Gln Arg Val Asp Leu Leu Glu Glu Ala Ala Asp Leu Leu Leu Ser
770 775 780
Cys Asn Asp Gln Tyr Glu Arg Ala Arg Val Leu Ala Asp Leu Ser Glu
785 790 795 800
Ala Phe Ser Ala Leu Arg His His Ser Arg Ala Arg Gly Leu Leu Arg
805 810 815
Gln Ala Arg His Leu Ala Ala Gln Cys Gly Ala Thr Pro Leu Leu Arg
820 825 830
Arg Leu Gly Ala Lys Pro Gly Gly Pro Gly Trp Leu Glu Glu Ser Gly
835 840 845
Leu Pro Gln Arg Ile Lys Ser Leu Thr Asp Ala Glu Arg Arg Val Ala
850 855 860
Ser Leu Ala Ala Gly Gly Gln Thr Asn Arg Val Ile Ala Asp Gln Leu
865 870 875 880
Phe Val Thr Ala Ser Thr Val Glu Gln His Leu Thr Asn Val Phe Arg
885 890 895
Lys Leu Gly Val Lys Gly Arg Gln His Leu Pro Ala Glu Leu Ala Asn
900 905 910
Ala Glu
<210> 199
<211> 875
<212> PRT
<213> Actinoplanes sp. N01-109
<400> 199
Met Pro Ala Val Lys Arg Asn Asp Leu Val Ala Arg Asp Gly Glu Leu
1 5 10 15
Arg Trp Met Gln Glu Ile Leu Ser Gln Ala Ser Glu Gly Arg Gly Ala
20 25 30
Val Val Thr Ile Thr Gly Ala Ile Ala Cys Gly Lys Thr Val Leu Leu
35 40 45
Asp Ala Ala Ala Ala Ser Gln Asp Val Ile Gln Leu Arg Ala Val Cys
50 55 60
Ser Ala Glu Glu Gln Glu Leu Pro Tyr Ala Met Val Gly Gln Leu Leu
65 70 75 80
Asp Asn Pro Val Leu Ala Ala Arg Val Pro Ala Leu Gly Asn Leu Ala
85 90 95
Ala Ala Gly Glu Arg Leu Leu Pro Gly Thr Glu Asn Arg Ile Arg Arg
100 105 110
Glu Leu Thr Arg Thr Leu Leu Ala Leu Ala Asp Glu Arg Pro Val Leu
115 120 125
Ile Gly Val Asp Asp Met His His Ala Asp Pro Ala Ser Leu Asp Cys
130 135 140
Leu Leu His Leu Ala Arg Arg Val Gly Pro Ala Arg Ile Ala Ile Val
145 150 155 160
Leu Thr Glu Leu Arg Arg Leu Thr Pro Ala His Ser Arg Phe Gln Ser
165 170 175
Glu Leu Leu Ser Leu Arg Tyr His His Glu Ile Gly Leu Gln Pro Leu
180 185 190
Thr Ala Glu His Thr Ala Asp Leu Ala Arg Val Gly Leu Gly Ala Glu
195 200 205
Val Asp Asp Asp Val Leu Thr Glu Leu Tyr Glu Ala Thr Gly Gly Asn
210 215 220
Pro Ser Leu Cys Cys Gly Leu Ile Arg Asp Val Arg Gln Asp Trp Glu
225 230 235 240
Ala Gly Val Thr Gly Ile His Val Gly Arg Ala Tyr Arg Leu Ala Tyr
245 250 255
Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ala Ala Leu Arg Thr Ala Arg
260 265 270
Ala Ala Ala Val Leu Gly Asp Ser Ala Asp Ala Cys Leu Ile Arg Arg
275 280 285
Val Ser Gly Leu Gly Thr Glu Ala Val Gly Gln Ala Ile Gln Gln Leu
290 295 300
Thr Glu Gly Gly Leu Leu Arg Asp Gln Gln Phe Pro His Pro Ala Ala
305 310 315 320
Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg His Ala Met
325 330 335
Tyr Arg Ser Ala Arg Glu Ala Ala Ala Glu Gly Gln Ala Asp Pro Gly
340 345 350
Thr Pro Gly Glu Pro Arg Ala Ala Thr Ala Tyr Ala Gly Cys Gly Glu
355 360 365
Gln Ala Gly Asp Tyr Pro Glu Pro Ala Gly Arg Ala Cys Val Asp Gly
370 375 380
Ala Gly Pro Ala Glu Tyr Cys Gly Asp Pro His Gly Ala Asp Asp Asp
385 390 395 400
Pro Asp Glu Leu Val Ala Ala Leu Gly Gly Leu Leu Pro Ser Arg Leu
405 410 415
Val Ala Met Lys Ile Arg Arg Leu Ala Val Ala Gly Arg Pro Gly Ala
420 425 430
Ala Ala Glu Leu Leu Thr Ser Gln Arg Leu His Ala Val Thr Ser Glu
435 440 445
Asp Arg Ala Ser Leu Arg Ala Ala Glu Val Ala Leu Ala Thr Leu Trp
450 455 460
Pro Gly Ala Thr Gly Pro Asp Arg His Pro Leu Thr Glu Gln Glu Ala
465 470 475 480
Ala Ser Leu Pro Glu Gly Pro Arg Leu Leu Ala Ala Ala Asp Asp Ala
485 490 495
Val Gly Ala Ala Leu Arg Gly Arg Ala Glu Tyr Ala Ala Ala Glu Ala
500 505 510
Glu Asn Val Leu Arg His Ala Asp Pro Ala Ala Gly Gly Asp Ala Tyr
515 520 525
Ala Ala Met Ile Ala Leu Leu Tyr Thr Glu His Pro Glu Asn Val Leu
530 535 540
Phe Trp Ala Asp Lys Leu Asp Ala Gly Arg Pro Asp Glu Glu Thr Ser
545 550 555 560
Tyr Pro Gly Leu Arg Ala Glu Thr Ala Val Arg Leu Gly Asp Leu Glu
565 570 575
Thr Ala Met Glu Leu Gly Arg Thr Val Leu Asp Gln Arg Arg Leu Pro
580 585 590
Ser Leu Gly Val Ala Ala Gly Leu Leu Leu Gly Gly Ala Val Thr Ala
595 600 605
Ala Ile Arg Leu Gly Asp Leu Asp Arg Ala Glu Lys Trp Leu Ala Glu
610 615 620
Pro Ile Pro Asp Ala Ile Arg Thr Ser Leu Tyr Gly Leu His Val Leu
625 630 635 640
Ala Ala Arg Gly Arg Leu Asp Leu Ala Ala Gly Arg Tyr Glu Ala Ala
645 650 655
Tyr Thr Ala Phe Arg Leu Cys Gly Glu Arg Met Ala Gly Trp Asp Ala
660 665 670
Asp Val Ser Gly Leu Ala Leu Trp Arg Val Asp Ala Ala Glu Ala Leu
675 680 685
Leu Ser Ala Gly Ile Arg Pro Asp Glu Gly Arg Lys Leu Ile Asp Asp
690 695 700
Gln Leu Thr Arg Glu Met Gly Ala Arg Ser Arg Ala Leu Thr Leu Arg
705 710 715 720
Ala Gln Ala Ala Tyr Ser Leu Pro Val His Arg Val Gly Leu Leu Asp
725 730 735
Glu Ala Ala Gly Leu Leu Leu Ala Cys His Asp Gly Tyr Glu Arg Ala
740 745 750
Arg Val Leu Ala Asp Leu Gly Glu Thr Leu Arg Thr Leu Arg His Thr
755 760 765
Asp Ala Ala Gln Arg Val Leu Arg Gln Ala Glu Gln Ala Ala Ala Arg
770 775 780
Cys Gly Ser Val Pro Leu Leu Arg Arg Leu Gly Ala Glu Pro Val Arg
785 790 795 800
Ile Gly Thr Arg Arg Gly Glu Pro Gly Leu Pro Gln Arg Ile Arg Leu
805 810 815
Leu Thr Asp Ala Glu Arg Arg Val Ala Ala Met Ala Ala Ala Gly Gln
820 825 830
Thr Asn Arg Glu Ile Ala Gly Arg Leu Phe Val Thr Ala Ser Thr Val
835 840 845
Glu Gln His Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg
850 855 860
Arg Phe Leu Pro Thr Glu Leu Ala Gln Ala Val
865 870 875
<210> 200
<211> 906
<212> PRT
<213> Streptomyces malaysiensis
<400> 200
Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu
1 5 10 15
Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly
20 25 30
Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr
35 40 45
Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg
50 55 60
Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly
65 70 75 80
Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala
85 90 95
Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg
100 105 110
Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg
115 120 125
Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser
130 135 140
Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile
145 150 155 160
Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg
165 170 175
Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu
180 185 190
Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe
195 200 205
Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr
210 215 220
Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu
225 230 235 240
Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg
245 250 255
Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg
260 265 270
Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu
275 280 285
Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr
290 295 300
Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg
325 330 335
Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val
340 345 350
Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro
355 360 365
Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg
370 375 380
Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala
385 390 395 400
Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala
405 410 415
Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu
420 425 430
Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala
435 440 445
Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala
450 455 460
Glu Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg
465 470 475 480
Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly
485 490 495
Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu
500 505 510
Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala
515 520 525
Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala
530 535 540
Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala
545 550 555 560
Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile
565 570 575
Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala
580 585 590
Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly
595 600 605
Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Ala Val Leu Asp Asp Arg
610 615 620
Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys
625 630 635 640
Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu
645 650 655
Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu
660 665 670
His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr
675 680 685
Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser
690 695 700
Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala
705 710 715 720
Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp
725 730 735
Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser His Ala Leu Thr Leu
740 745 750
Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu
755 760 765
His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln
770 775 780
Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg
785 790 795 800
Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr
805 810 815
Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly
820 825 830
Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp
835 840 845
Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg
850 855 860
Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His
865 870 875 880
Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu
885 890 895
Pro Thr Ala Leu Ala Asp Val Glu Gln Thr
900 905
<210> 201
<211> 904
<212> PRT
<213> Streptomyces violaceusniger
<400> 201
Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu
1 5 10 15
Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Glu Ala Gly Ser Gly
20 25 30
Gln Gly Ala Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr
35 40 45
Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Asp Ala Ile Ile Leu Arg
50 55 60
Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly
65 70 75 80
Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Glu Leu Ala
85 90 95
Asp Arg Ile Ala Gln Gly Gly His Leu Ser Leu Arg Ala Glu Asn Arg
100 105 110
Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val Asp Arg
115 120 125
Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser
130 135 140
Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile
145 150 155 160
Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg
165 170 175
Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu
180 185 190
Arg Pro Leu Gly Pro Glu Gln Ser Ala Glu Leu Ala His Ala Ala Phe
195 200 205
Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Gly Met Thr
210 215 220
Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu
225 230 235 240
Ala Gln Ala Asn Gly Glu Ser Ala Phe Glu Val Gly Arg Ala Phe Arg
245 250 255
Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Ile Ala Leu Arg
260 265 270
Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu
275 280 285
Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr
290 295 300
Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp His Gln Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg
325 330 335
Arg Ser Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val
340 345 350
Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro
355 360 365
Lys Ala Ala Glu Ile Phe Ala Arg Ala Gly Gln Ala Leu Val Val Arg
370 375 380
Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala
385 390 395 400
Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala
405 410 415
Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu
420 425 430
Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala
435 440 445
Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala
450 455 460
Glu Val Leu Ala Ser Glu His Pro Leu Ala Thr Thr Asp Gln Asn Arg
465 470 475 480
Ala His Leu Arg Phe Ala Glu Val Thr Leu Ala Leu Phe Cys Pro Gly
485 490 495
Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Ala Pro Asp Glu Leu
500 505 510
Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala
515 520 525
Val Met Thr Ala Leu His Ala His Pro Glu Leu Ala Thr Ala Gln Ala
530 535 540
Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala
545 550 555 560
Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala Gln Ile
565 570 575
Trp Ala Asp Lys Leu Gly Ser Thr Asn Ala Gly Val Ser Asn Glu Ala
580 585 590
Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly
595 600 605
Asp Leu Ala Thr Ala Phe Glu Ala Gly Gly Thr Val Leu Asp Asp Arg
610 615 620
Pro Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys
625 630 635 640
Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu
645 650 655
Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu
660 665 670
His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr
675 680 685
Glu Ser Ala His Arg Ala Phe His Thr Cys Gly Glu Arg Met Arg Ser
690 695 700
Trp Gly Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala
705 710 715 720
Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp
725 730 735
Glu Gln Leu Ala Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu
740 745 750
Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu
755 760 765
His Glu Ala Ala Glu Leu Leu Leu Ser Cys Pro Asp Pro Tyr Glu Gln
770 775 780
Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg
785 790 795 800
Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr
805 810 815
Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly
820 825 830
Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp
835 840 845
Ala Glu Arg Arg Val Ser Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg
850 855 860
Glu Ile Ala Lys Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His
865 870 875 880
Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Arg Gln Leu
885 890 895
Pro Thr Ala Leu Ala Asp Val Glu
900
<210> 202
<211> 906
<212> PRT
<213> Streptomyces Sp. NRRL F-4729
<400> 202
Met Tyr Ser Gly Thr Cys Arg Glu Gly Tyr Glu Leu Val Ala Arg Glu
1 5 10 15
Asp Glu Leu Gly Ile Leu Gln Arg Ser Leu Glu Gln Ala Ser Ser Gly
20 25 30
Gln Gly Val Val Val Thr Val Thr Gly Pro Ile Ala Cys Gly Lys Thr
35 40 45
Glu Leu Leu Asp Ala Ala Ala Ala Lys Ala Glu Ala Ile Ile Leu Arg
50 55 60
Ala Val Cys Ala Pro Glu Glu Arg Ala Met Pro Tyr Ala Met Ile Gly
65 70 75 80
Gln Leu Ile Asp Asp Pro Ala Leu Ala His Arg Ala Pro Gly Leu Ala
85 90 95
Asp Arg Ile Ala Gln Gly Gly Gln Leu Ser Leu Arg Ala Glu Asn Arg
100 105 110
Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Ala Leu Ala Val His Arg
115 120 125
Pro Val Leu Ile Gly Val Asp Asp Val His His Ala Asp Thr Ala Ser
130 135 140
Leu Asn Cys Leu Leu His Leu Ala Arg Arg Val Arg Pro Ala Arg Ile
145 150 155 160
Ser Met Ile Phe Thr Glu Leu Arg Ser Leu Thr Pro Thr Gln Ser Arg
165 170 175
Phe Lys Ala Glu Leu Leu Ser Leu Pro Tyr His His Glu Ile Ala Leu
180 185 190
Arg Pro Phe Gly Pro Glu Gln Ser Ala Glu Leu Ala Arg Ala Ala Phe
195 200 205
Gly Pro Gly Leu Ala Glu Asp Val Leu Ala Gly Leu Tyr Lys Thr Thr
210 215 220
Arg Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Ser Asp Val Arg Glu
225 230 235 240
Ala Leu Ala Asn Gly Glu Ser Ala Phe Glu Ala Gly Arg Ala Phe Arg
245 250 255
Leu Ala Tyr Leu Ser Ser Leu Tyr Arg Cys Gly Pro Val Ala Leu Arg
260 265 270
Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Thr Thr Leu
275 280 285
Val Arg Arg Leu Ser Gly Leu Ser Ala Glu Thr Ile Asp Arg Ala Thr
290 295 300
Lys Ile Leu Thr Glu Gly Gly Leu Leu Leu Asp Gln Gln Phe Pro His
305 310 315 320
Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Gln Glu Arg
325 330 335
Arg Gly Leu His Thr Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro Val
340 345 350
Glu Val Leu Ala His His Gln Val Gly Ala Gly Leu Ile His Gly Pro
355 360 365
Lys Ala Ala Glu Met Phe Ala Lys Ala Gly Lys Ala Leu Val Val Arg
370 375 380
Asn Glu Leu Gly Asp Ala Ala Glu Tyr Leu Gln Leu Ala His Arg Ala
385 390 395 400
Ser Asp Asp Val Ser Thr Arg Ala Ala Leu Arg Val Glu Ala Val Ala
405 410 415
Ile Glu Arg Arg Arg Asn Pro Leu Ala Ser Ser Arg His Met Asp Glu
420 425 430
Leu Ser Ala Ala Gly Arg Ala Gly Leu Leu Ser Pro Lys His Ala Ala
435 440 445
Leu Ala Val Phe Trp Leu Ala Asp Gly Gly Arg Ser Gly Glu Ala Ala
450 455 460
Gln Val Leu Ala Ser Glu Arg Pro Leu Ala Thr Thr Asp Gln Asn Arg
465 470 475 480
Ala His Leu Arg Phe Val Glu Val Thr Leu Ala Leu Phe Ser Pro Gly
485 490 495
Ala Phe Gly Ser Asp Arg Arg Pro Pro Pro Leu Thr Pro Asp Glu Leu
500 505 510
Ala Ser Leu Pro Lys Ala Ala Trp Gln Cys Ala Val Ala Asp Asn Ala
515 520 525
Ala Met Thr Ala Leu His Gly His Pro Glu Leu Ala Thr Ala Gln Ala
530 535 540
Glu Thr Val Leu Arg Gln Ala Asp Ser Ala Ala Asp Ala Ile Pro Ala
545 550 555 560
Ala Leu Ile Ala Leu Leu Tyr Ala Glu Asn Thr Glu Ser Ala His Ile
565 570 575
Trp Ala Asp Lys Leu Gly Ser Met Asn Ala Gly Val Ser Asn Glu Ala
580 585 590
Glu Ala Gly Tyr Ala Gly Pro Cys Ala Glu Ile Ala Leu Arg Arg Gly
595 600 605
Asp Leu Ala Thr Ala Phe Glu Ala Gly Ser Thr Val Leu Asp Asp Arg
610 615 620
Ser Leu Pro Ser Leu Gly Ile Thr Ala Ala Leu Leu Leu Ser Ser Lys
625 630 635 640
Thr Ala Ala Ala Val Arg Leu Gly Glu Leu Glu Arg Ala Glu Lys Leu
645 650 655
Leu Ala Glu Pro Leu Pro Asn Gly Val Gln Asp Ser Leu Phe Gly Leu
660 665 670
His Leu Leu Ser Ala Tyr Gly Gln Tyr Ser Leu Ala Met Gly Arg Tyr
675 680 685
Glu Ser Ala His Arg Ala Phe Arg Thr Cys Gly Glu Arg Met Arg Ser
690 695 700
Trp Asp Val Asp Val Pro Gly Leu Ala Leu Trp Arg Val Asp Ala Ala
705 710 715 720
Glu Ala Leu Leu Ser Leu Asp Arg Asn Glu Gly Gln Arg Leu Ile Asp
725 730 735
Glu Gln Leu Thr Arg Pro Met Gly Pro Arg Ser Arg Ala Leu Thr Leu
740 745 750
Arg Ile Lys Ala Ala Tyr Leu Pro Arg Thr Lys Arg Ile Pro Leu Leu
755 760 765
His Glu Ala Ala Glu Leu Leu Leu Pro Cys Pro Asp Pro Tyr Glu Gln
770 775 780
Ala Arg Val Leu Ala Asp Leu Gly Asp Thr Leu Ser Ala Leu Arg Arg
785 790 795 800
Tyr Ser Arg Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Thr
805 810 815
Gln Cys Gly Ala Val Pro Leu Leu Arg Arg Leu Gly Gly Glu Pro Gly
820 825 830
Arg Ile Asp Asp Ala Gly Leu Pro Gln Arg Ser Thr Ser Leu Thr Asp
835 840 845
Ala Glu Arg Arg Val Ala Ala Leu Ala Ala Ala Gly Gln Thr Asn Arg
850 855 860
Glu Ile Ala Glu Gln Leu Phe Val Thr Ala Ser Thr Val Glu Gln His
865 870 875 880
Leu Thr Ser Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu
885 890 895
Pro Thr Ala Leu Ala Asp Val Glu Gln Thr
900 905
<210> 203
<211> 904
<212> PRT
<213> Streptomyces filamentosus
<400> 203
Met Arg Ala Ile Asn Ala Ser Asp Thr Gly Pro Glu Leu Val Ala Arg
1 5 10 15
Glu Asp Glu Leu Gly Arg Val Arg Ser Ala Leu Asn Arg Ala Asn Gly
20 25 30
Gly Gln Gly Val Leu Ile Ser Ile Thr Gly Pro Ile Ala Cys Gly Lys
35 40 45
Thr Glu Leu Leu Glu Ala Ala Ala Ser Glu Val Asp Ala Ile Thr Leu
50 55 60
Arg Ala Val Cys Ala Ala Glu Glu Arg Ala Ile Pro Tyr Ala Leu Ile
65 70 75 80
Gly Gln Leu Ile Asp Asn Pro Ala Leu Gly Ile Pro Val Pro Asp Pro
85 90 95
Ala Gly Leu Thr Ala Gln Gly Gly Arg Leu Ser Ser Ser Ala Glu Asn
100 105 110
Arg Leu Arg Arg Asp Leu Thr Arg Ala Leu Leu Thr Leu Ala Thr Asp
115 120 125
Arg Leu Val Leu Ile Cys Val Asp Asp Val Gln His Ala Asp Asn Ala
130 135 140
Ser Leu Ser Cys Leu Leu Tyr Leu Ala Arg Arg Leu Val Pro Ala Arg
145 150 155 160
Ile Ala Leu Val Phe Thr Glu Leu Arg Val Leu Thr Ser Ser Gln Leu
165 170 175
Arg Phe Asn Ala Glu Leu Leu Ser Leu Arg Asn His Cys Glu Ile Ala
180 185 190
Leu Arg Pro Leu Gly Pro Gly His Ala Ala Glu Leu Ala Arg Ala Thr
195 200 205
Leu Gly Pro Gly Leu Ser Asp Glu Thr Leu Thr Glu Leu Tyr Arg Val
210 215 220
Thr Gly Gly Asn Leu Ser Leu Ser Arg Gly Leu Ile Asp Asp Val Arg
225 230 235 240
Asp Ala Trp Ala Arg Gly Glu Thr Gly Val Gln Val Gly Arg Ala Phe
245 250 255
Arg Leu Ala Tyr Leu Gly Ser Leu His Arg Cys Gly Pro Leu Ala Leu
260 265 270
Arg Val Ala Arg Val Ala Ala Val Leu Gly Pro Ser Ala Thr Ser Val
275 280 285
Leu Val Arg Arg Ile Ser Gly Leu Ser Ala Glu Ala Met Ala Gln Ala
290 295 300
Thr Asp Ile Leu Ala Asp Gly Gly Leu Leu Arg Asp Gln Arg Phe Thr
305 310 315 320
His Pro Ala Ala Arg Ser Val Val Leu Asp Asp Met Ser Ala Glu Glu
325 330 335
Arg Arg Ser Val His Ser Leu Ala Leu Glu Leu Leu Asp Glu Ala Pro
340 345 350
Ala Glu Met Leu Ala His His Arg Val Gly Ala Gly Leu Val His Gly
355 360 365
Pro Lys Ala Ala Glu Thr Phe Thr Gly Ala Gly Arg Ala Leu Ala Val
370 375 380
Arg Gly Met Leu Gly Glu Ala Ala Asp Tyr Leu Gln Leu Ala Tyr Arg
385 390 395 400
Ala Ser Gly Asp Ala Ala Thr Lys Ala Ala Ile Arg Val Glu Ser Val
405 410 415
Ala Val Glu Arg Arg Arg Asn Pro Leu Val Val Ser Arg His Trp Asp
420 425 430
Glu Leu Ser Val Ala Ala Arg Ala Gly Leu Leu Ser Cys Glu His Val
435 440 445
Ser Arg Thr Ala Arg Trp Leu Thr Val Gly Gly Arg Pro Gly Glu Ala
450 455 460
Ala Arg Val Leu Ala Ser Gln His Arg Arg Val Val Thr Asp Gln Asp
465 470 475 480
Arg Ala His Leu Arg Val Ala Glu Phe Ser Leu Ala Leu Leu Tyr Pro
485 490 495
Gly Thr Ser Gly Ser Asp Arg Arg Pro His Pro Leu Thr Ser Asp Glu
500 505 510
Leu Ala Ala Leu Pro Thr Ala Thr Arg His Cys Ala Ile Ala Asp Asn
515 520 525
Ala Val Met Ala Ala Leu Arg Gly His Pro Glu Leu Ala Thr Ala Glu
530 535 540
Ala Glu Ala Val Leu Gln Gln Ala Asp Ala Ala Asp Gly Ala Ala Leu
545 550 555 560
Thr Ala Leu Met Ala Leu Leu Tyr Ala Glu Ser Ile Glu Val Ala Glu
565 570 575
Val Trp Ala Asp Lys Leu Ala Ala Glu Ala Gly Ala Ser Asn Gly Gln
580 585 590
Asp Ala Glu Tyr Ala Gly Ile Arg Ala Glu Ile Ala Leu Arg Arg Gly
595 600 605
Asp Leu Thr Ala Ala Val Glu Thr Ala Gly Met Val Leu Asp Gly Arg
610 615 620
Pro Leu Pro Ser Leu Asp Ile Thr Ala Thr Leu Leu Leu Ala Gly Arg
625 630 635 640
Ala Ser Val Ala Val Arg Leu Gly Glu Leu Asp His Ala Glu Glu Leu
645 650 655
Phe Ala Ala Pro Pro Glu Asp Ala Phe Gln Asp Ser Leu Phe Gly Leu
660 665 670
His Leu Leu Ser Ala His Gly Gln Tyr Ser Leu Ala Thr Gly Arg Pro
675 680 685
Glu Ser Ala Tyr Arg Ala Phe Arg Ala Cys Gly Glu Arg Met Arg Asp
690 695 700
Trp Gly Phe Asp Ala Pro Gly Val Ala Leu Trp Arg Val Gly Ala Ala
705 710 715 720
Glu Ala Leu Leu Gly Leu Asp Arg Asn Glu Gly Arg Arg Leu Ile Asp
725 730 735
Glu Gln Leu Ser Arg Thr Met Ala Pro Arg Ser His Ala Leu Thr Leu
740 745 750
Arg Ile Lys Ala Ala Tyr Met Pro Glu Pro Lys Arg Val Asp Leu Leu
755 760 765
Tyr Glu Ala Ala Glu Leu Leu Leu Ser Cys Arg Asp Gln Tyr Glu Arg
770 775 780
Ala Arg Val Leu Ala Asp Leu Gly Glu Ala Leu Ser Ala Leu Gly Asn
785 790 795 800
Tyr Arg Gln Ala Arg Gly Val Leu Arg Gln Ala Arg His Leu Ala Met
805 810 815
Arg Thr Gly Ala Asp Pro Leu Leu Arg Arg Leu Gly Ile Arg Pro Gly
820 825 830
Arg Gln Asp Asp Pro Asp Pro Gln Pro Arg Ser Arg Ser Leu Thr Asn
835 840 845
Ala Glu Arg Arg Ala Ala Ser Leu Ala Ala Thr Gly Leu Thr Asn Arg
850 855 860
Glu Ile Ala Asp Arg Leu Phe Val Thr Ala Ser Thr Val Glu Gln His
865 870 875 880
Leu Thr Asn Val Phe Arg Lys Leu Gly Val Lys Gly Arg Lys Gln Leu
885 890 895
Pro Ala Glu Leu Asp Asp Met Glu
900
<210> 204
<211> 6
<212> DNA
<213> Artificial Sequence
<220>
<223> Synthetic Construct
<400> 204
aggggg 6
Claims (51)
- 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제이며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 1개 이상의 이종 모듈은 폴리케티드 생합성 동안 폴리케티드 전위를 실질적으로 억제하지 않는 것인, 조작된 폴리케티드 신타제.
- 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제이며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 1개 이상의 이종 모듈은 그에 인접한 모듈의 연결 서열에 상용성인 연결 서열을 포함하는 것인, 조작된 폴리케티드 신타제.
- 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제이며, 여기서 조작된 폴리케티드 신타제는 조작된 폴리케티드 신타제에 의해 화합물을 발현하게 하는데 적합한 조건 하에 발현되는 경우에 폴리케티드를 생산할 수 있고, 조작된 폴리케티드 신타제의 폴리케티드 발현 수준은 참조 폴리케티드 신타제의 폴리케티드 발현 수준의 적어도 1%인, 조작된 폴리케티드 신타제.
- 제1항 내지 제3항 중 어느 한 항에 있어서, 1개 이상의 이종 모듈이 천연 연결 서열을 포함하는 것인 조작된 폴리케티드 신타제.
- 제1항 내지 제4항 중 어느 한 항에 있어서, 2개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제.
- 제5항에 있어서, 2개 이상의 이종 모듈이 인접한 것인 조작된 폴리케티드 신타제.
- 제1항 내지 제6항 중 어느 한 항에 있어서, 3개 이상의 이종 모듈을 포함하는 조작된 폴리케티드 신타제.
- 제7항에 있어서, 3개 이상의 이종 모듈이 인접한 것인 조작된 폴리케티드 신타제.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 이종 모듈이 폴리케티드의 가변 영역 내 β-카르보닐 단위를 변형시키는 신장 모듈인 조작된 폴리케티드 신타제.
- 제1항 내지 제9항 중 어느 한 항에 있어서, 1개 이상의 이종 모듈 중 적어도 하나가 서열식별번호: 1-174 중 어느 하나에 대해 적어도 90% 동일성을 갖는 부분을 포함하는 것인 조작된 폴리케티드 신타제.
- 제1항 내지 제10항 중 어느 한 항에 있어서, 1개 이상의 이종 모듈 중 적어도 하나가 서열식별번호: 1-174 중 어느 하나의 서열을 갖는 부분을 포함하는 것인 조작된 폴리케티드 신타제.
- 키메라 폴리케티드 신타제이며, 그의 적어도 1개의 모듈이 서열식별번호: 175-176의 서열을 갖는 폴리케티드 신타제와 비교하여 변형된 것인, 키메라 폴리케티드 신타제.
- 제12항에 있어서, 적어도 1개의 모듈이 서열식별번호: 1-174 중 어느 하나에 대해 적어도 90% 동일성을 갖는 부분을 포함하는 것인 키메라 폴리케티드 신타제.
- 제1항 내지 제13항 중 어느 한 항의 폴리케티드 신타제를 코딩하는 핵산.
- 제15항에 있어서, 핵산이 LAL을 추가로 코딩하고, LAL을 코딩하는 서열이 폴리케티드 신타제를 코딩하는 서열에 작동가능하게 연결되는 것인 핵산.
- 제15항에 있어서, LAL이 이종 LAL인 핵산.
- 제15항 또는 제16항에 있어서, LAL이 서열식별번호: 177에 대해 적어도 80% 동일성을 갖는 부분을 포함하는 것인 핵산.
- 제17항에 있어서, LAL이 서열식별번호: 177의 서열을 갖는 부분을 포함하는 것인 핵산.
- 제18항에 있어서, LAL이 서열식별번호: 177의 서열을 갖는 것인 핵산.
- 제14항 내지 제19항 중 어느 한 항에 있어서, LAL을 코딩하는 핵산이 오픈 리딩 프레임 내 TTA 억제 코돈이 결여되어 있는 것인 핵산.
- 제14항 내지 제20항 중 어느 한 항에 있어서, 핵산이 LAL 결합 부위를 추가로 포함하고, LAL 결합 부위를 코딩하는 서열이 폴리케티드 신타제를 코딩하는 서열에 작동가능하게 연결되는 것인 핵산.
- 제21항에 있어서, LAL 결합 부위가 서열식별번호: 178의 서열에 대해 적어도 80% 서열 동일성을 갖는 부분을 포함하는 것인 핵산.
- 제22항에 있어서, LAL 결합 부위가 서열식별번호: 178의 서열을 갖는 부분을 포함하는 것인 핵산.
- 제23항에 있어서, LAL 결합 부위가 서열식별번호: 178의 서열을 갖는 것인 핵산.
- 제21항에 있어서, LAL 결합 부위가 서열 GGGGGT (서열식별번호: 179)를 갖는 것인 핵산.
- 제21항 내지 제25항 중 어느 한 항에 있어서, LAL 결합 부위에 대한 LAL의 결합이 폴리케티드 신타제의 발현을 촉진하는 것인 핵산.
- 제14항 내지 제26항 중 어느 한 항에 있어서, 비리보솜 펩티드 신타제를 추가로 코딩하는 핵산.
- 제14항 내지 제27항 중 어느 한 항에 있어서, 제1 P450 효소를 추가로 코딩하는 핵산.
- 제28항에 있어서, 제2 P450 효소를 추가로 코딩하는 핵산.
- 제14항 내지 제29항 중 어느 한 항의 핵산을 포함하는 발현 벡터.
- 제30항에 있어서, 인공 염색체인 발현 벡터.
- 제31항에 있어서, 인공 염색체가 박테리아 인공 염색체인 발현 벡터.
- 제30항 내지 제32항 중 어느 한 항의 발현 벡터를 포함하는 숙주 세포.
- 제1항 내지 제13항 중 어느 한 항의 폴리케티드 신타제를 포함하는 숙주 세포이며, 여기서 폴리케티드는 숙주 세포에 대해 이종인, 숙주 세포.
- 제33항 또는 제34항에 있어서, 자연적으로 LAL이 결여되어 있는 숙주 세포.
- 제33항 내지 제35항 중 어느 한 항에 있어서, 자연적으로 LAL 결합 부위가 결여되어 있는 숙주 세포.
- 제33항 내지 제36항 중 어느 한 항에 있어서, LAL 결합 부위에 결합할 수 있고 폴리케티드 신타제의 발현을 조절할 수 있는 LAL을 포함하는 숙주 세포.
- 제37항에 있어서, LAL이 이종인 숙주 세포.
- 제37항 또는 제38항에 있어서, LAL이 서열식별번호: 177의 서열에 대해 적어도 80% 동일성을 갖는 부분을 포함하는 것인 숙주 세포.
- 제33항 내지 제39항 중 어느 한 항에 있어서, 박테리아인 숙주 세포.
- 제40항에 있어서, 박테리아가 악티노박테리아인 숙주 세포.
- 제41항에 있어서, 악티노박테리아가 스트렙토미세스 암보파시엔스(Streptomyces ambofaciens), 스트렙토미세스 히그로스코피쿠스(Streptomyces hygroscopicus) 또는 스트렙토미세스 말라이옌시스(Streptomyces malayensis)인 숙주 세포.
- 제42항에 있어서, 악티노박테리아가 S1391, S1496 또는 S2441인 숙주 세포.
- 제33항 내지 제43항 중 어느 한 항에 있어서, 폴리케티드 신타제의 발현을 증진시키도록 변형된 숙주 세포.
- 제44항에 있어서, (i) 화합물-생산 단백질을 발현하는 내인성 유전자 클러스터의 결실; (ii) 화합물-생산 단백질을 발현하는 이종 유전자 클러스터의 삽입; (iii) 항생제 챌린지에 대한 숙주 세포의 노출; 및/또는 (iv) 동종 프로모터와 비교하여 화합물 발현을 적어도 2배 증가시키는 이종 프로모터의 도입에 의해 화합물-생산 단백질의 발현을 증진시키도록 변형된 숙주 세포.
- 제33항 내지 제45항 중 어느 한 항의 숙주 세포를 적합한 조건 하에 배양하는 것을 포함하는, 폴리케티드를 생산하는 방법.
- 제1항 내지 제13항 중 어느 한 항의 폴리케티드 신타제를 발현하도록 조작된 숙주 세포를 폴리케티드 신타제가 폴리케티드를 생산하는데 적합한 조건 하에 배양하는 것을 포함하는, 폴리케티드를 생산하는 방법.
- (a) 화합물을 생산할 수 있는 모 폴리케티드 신타제 서열을 제공하는 단계;
(b) 제2 폴리케티드 신타제의 적어도 1개의 모듈과 모 폴리케티드 신타제의 적어도 2개의 모듈과의 상용성을 결정하는 단계;
(c) 변형된 폴리케티드 신타제를 코딩하는 핵산을 생산하는 단계이며, 여기서 변형된 폴리케티드 신타제는 모 폴리케티드 신타제의 적어도 2개의 모듈과 상용성인 것으로 결정된 제2 폴리케티드 신타제의 적어도 1개의 모듈을 포함하는 것인 단계
를 포함하는, 화합물을 생산하는 방법. - (a) 모 폴리케티드 신타제를 코딩하는 모 핵산을 제공하는 단계;
(b) 모 핵산을 변형시켜 화합물을 생산할 수 있는 변형된 폴리케티드 신타제를 코딩하는 변형된 핵산을 생성하는 단계이며, 여기서 변형은 적어도 1개의 이종 모듈을 포함하는 변형된 폴리케티드 신타제를 생산하는 것인 단계
를 포함하는, 화합물을 생산하는 방법. - (a) 화합물을 생산할 수 있는 모 폴리뉴클레오티드 서열을 제공하는 단계;
(b) 모 폴리뉴클레오티드 서열 내 1개 이상의 모듈의 대체에 적합한 1개 이상의 이종 모듈을 확인하는 단계;
(c) 변형된 폴리케티드 신타제를 코딩하는 핵산을 생산하는 단계이며, 여기서 변형된 폴리케티드 신타제는 단계 (b)에서 확인된 적어도 1개의 이종 모듈을 포함하는 것인 단계
를 포함하는, 화합물을 생산하는 방법. - 복수의 폴리뉴클레오티드를 생산하는 방법이며, 여기서 각각의 복수의 폴리뉴클레오티드는 조작된 폴리케티드 신타제에 상응하고, 각각의 복수의 폴리뉴클레오티드는 참조 폴리케티드에 비해 변경된 효소적 활성을 갖는 1개 이상의 이종 모듈을 포함하고, 방법은
(a) 폴리케티드 신타제를 코딩하는 모 폴리뉴클레오티드 서열을 제공하는 단계;
(b) 모 폴리뉴클레오티드 서열 내 대체를 위한 1개 이상의 모듈을 확인하는 단계;
(c) 단계 (b)에서 확인된 각각의 모듈에 대한 대체에 적합한 2개 이상의 이종 모듈을 확인하는 단계;
(d) 복수의 폴리뉴클레오티드를 생성하는 단계이며, 여기서 각각의 복수의 폴리뉴클레오티드는 조작된 폴리케티드 신타제에 상응하고, 각각의 복수의 폴리뉴클레오티드는 단계 (b)에서 확인된 대체될 각각의 1개 이상의 모듈 대신에 단계 (c)에서 확인된 2개 이상의 이종 모듈로부터 선택된 이종 모듈을 포함하는 것인 단계
를 포함하는 것인, 복수의 폴리뉴클레오티드를 생산하는 방법.
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US6960453B1 (en) * | 1996-07-05 | 2005-11-01 | Biotica Technology Limited | Hybrid polyketide synthases combining heterologous loading and extender modules |
US20030153053A1 (en) * | 2001-08-06 | 2003-08-14 | Ralph Reid | Methods for altering polyketide synthase genes |
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