KR20190078646A - 디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 - Google Patents

디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 Download PDF

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KR20190078646A
KR20190078646A KR1020197016983A KR20197016983A KR20190078646A KR 20190078646 A KR20190078646 A KR 20190078646A KR 1020197016983 A KR1020197016983 A KR 1020197016983A KR 20197016983 A KR20197016983 A KR 20197016983A KR 20190078646 A KR20190078646 A KR 20190078646A
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alkyl
fluorophenyl
chlorophenyl
synthesis
carboxamide
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Inventor
동-밍 쉔
토마스 에이치. 그레이엄
웬쉥 리우
클레어 투지
안드레아스 베라스
진롱 지앙
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머크 샤프 앤드 돔 코포레이션
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020197016983A 2016-11-18 2017-11-13 디아실글리세리드 o-아실트랜스퍼라제 2의 억제제로서 유용한 인다졸 유도체 Withdrawn KR20190078646A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662424066P 2016-11-18 2016-11-18
US62/424,066 2016-11-18
PCT/US2017/061223 WO2018093696A1 (en) 2016-11-18 2017-11-13 Indazole derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2

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KR20190078646A true KR20190078646A (ko) 2019-07-04

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US (1) US11104690B2 (enExample)
EP (1) EP3541374A4 (enExample)
JP (1) JP2020502058A (enExample)
KR (1) KR20190078646A (enExample)
CN (1) CN110121341A (enExample)
AU (1) AU2017360939B2 (enExample)
BR (1) BR112019010164A2 (enExample)
CA (1) CA3043203A1 (enExample)
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MX (1) MX2019005786A (enExample)
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US11787810B2 (en) 2020-05-18 2023-10-17 Merck Sharp & Dohme Llc Diacylglyceride O-acyltransferase 2 inhibitors
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KR20230084258A (ko) 2020-10-08 2023-06-12 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의 벤즈이미다졸론 유도체의 제조
KR20230124989A (ko) * 2020-12-22 2023-08-28 머크 샤프 앤드 돔 엘엘씨 신규 디아실글리세리드 o-아실트랜스퍼라제 2 억제제로서의테트라히드로인다졸 유도체의 제조
KR20240165402A (ko) 2022-03-23 2024-11-22 아이디어야 바이오사이언시스 인코포레이티드 Parg의 억제제로서의 피페라진 치환된 인다졸 화합물
CN120500483A (zh) 2022-12-02 2025-08-15 默沙东有限责任公司 作为新型二酰基甘油o-酰基转移酶2抑制剂的稠合唑衍生物的制备

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AU2017360939B2 (en) 2022-03-03
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EP3541374A1 (en) 2019-09-25
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EP3541374A4 (en) 2020-06-10
MA46856A (fr) 2019-09-25
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