KR20190066037A - 샘플을 테스트하기 위한 분석 시스템 및 방법 - Google Patents

샘플을 테스트하기 위한 분석 시스템 및 방법 Download PDF

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Publication number
KR20190066037A
KR20190066037A KR1020197012881A KR20197012881A KR20190066037A KR 20190066037 A KR20190066037 A KR 20190066037A KR 1020197012881 A KR1020197012881 A KR 1020197012881A KR 20197012881 A KR20197012881 A KR 20197012881A KR 20190066037 A KR20190066037 A KR 20190066037A
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KR
South Korea
Prior art keywords
sensor
nucleic acid
capture
target
assay
Prior art date
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Ceased
Application number
KR1020197012881A
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English (en)
Korean (ko)
Inventor
마티아스 그리스너
하인츠 쇠더
Original Assignee
베링거잉겔하임베트메디카게엠베하
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Publication of KR20190066037A publication Critical patent/KR20190066037A/ko
Ceased legal-status Critical Current

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0819—Microarrays; Biochips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Fluid Mechanics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
KR1020197012881A 2016-10-07 2017-10-05 샘플을 테스트하기 위한 분석 시스템 및 방법 Ceased KR20190066037A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16020373.3 2016-10-07
EP16020373 2016-10-07
PCT/EP2017/025281 WO2018065104A1 (en) 2016-10-07 2017-10-05 Analysis system and method for testing a sample

Publications (1)

Publication Number Publication Date
KR20190066037A true KR20190066037A (ko) 2019-06-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197012881A Ceased KR20190066037A (ko) 2016-10-07 2017-10-05 샘플을 테스트하기 위한 분석 시스템 및 방법

Country Status (8)

Country Link
US (2) US10597703B2 (enExample)
EP (1) EP3523030B1 (enExample)
JP (1) JP2019536441A (enExample)
KR (1) KR20190066037A (enExample)
CN (1) CN110114145B (enExample)
BR (1) BR112019007081A2 (enExample)
CA (1) CA3037217A1 (enExample)
WO (1) WO2018065104A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12385038B2 (en) 2018-10-11 2025-08-12 Bruker Cellular Analysis, Inc. Systems and methods for identification of optimized protein production and kits therefor

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WO2019063602A1 (en) * 2017-09-29 2019-04-04 Boehringer Ingelheim Vetmedica Gmbh SENSOR APPARATUS AND METHOD FOR TESTING A SAMPLE
CN111630190A (zh) 2017-12-20 2020-09-04 勃林格殷格翰动物保健有限公司 经修饰的活猪流感病毒疫苗的检测
CN113316716B (zh) 2019-01-11 2025-05-13 弗雷德传感科技公司 用于伏安检测的系统和方法
EP4179325A4 (en) * 2019-10-04 2024-10-02 University of Cincinnati READY-TO-USE, STORAGE-STABLE ELECTROCHEMICAL APTAMER SENSORS
JP2023546790A (ja) * 2020-09-24 2023-11-08 イノテック プリシジョン メディスン インコーポレイテッド 病原体を検出するためのシステム、装置、および方法
WO2022128917A1 (en) 2020-12-14 2022-06-23 Boehringer Ingelheim Vetmedica Gmbh Analysis system and method for testing a sample
WO2023210026A1 (en) * 2022-04-26 2023-11-02 The University Of Tokyo Sensor

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US6942771B1 (en) * 1999-04-21 2005-09-13 Clinical Micro Sensors, Inc. Microfluidic systems in the electrochemical detection of target analytes
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Publication number Priority date Publication date Assignee Title
US12385038B2 (en) 2018-10-11 2025-08-12 Bruker Cellular Analysis, Inc. Systems and methods for identification of optimized protein production and kits therefor

Also Published As

Publication number Publication date
CN110114145B (zh) 2022-08-09
US10597703B2 (en) 2020-03-24
JP2019536441A (ja) 2019-12-19
US20180100188A1 (en) 2018-04-12
US20200172965A1 (en) 2020-06-04
CN110114145A (zh) 2019-08-09
BR112019007081A2 (pt) 2019-07-09
EP3523030B1 (en) 2021-05-05
WO2018065104A1 (en) 2018-04-12
EP3523030A1 (en) 2019-08-14
CA3037217A1 (en) 2018-04-12
US10988799B2 (en) 2021-04-27

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