KR20190053215A - 약물 전달을 위한 침투 증진제를 함유하는 조성물 - Google Patents

약물 전달을 위한 침투 증진제를 함유하는 조성물 Download PDF

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Publication number
KR20190053215A
KR20190053215A KR1020197010227A KR20197010227A KR20190053215A KR 20190053215 A KR20190053215 A KR 20190053215A KR 1020197010227 A KR1020197010227 A KR 1020197010227A KR 20197010227 A KR20197010227 A KR 20197010227A KR 20190053215 A KR20190053215 A KR 20190053215A
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KR
South Korea
Prior art keywords
composition
penetration enhancer
certain embodiments
therapeutic agent
sol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020197010227A
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English (en)
Korean (ko)
Inventor
다니엘 에스. 코핸
롱 양
Original Assignee
칠드런'즈 메디컬 센터 코포레이션
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Application filed by 칠드런'즈 메디컬 센터 코포레이션 filed Critical 칠드런'즈 메디컬 센터 코포레이션
Publication of KR20190053215A publication Critical patent/KR20190053215A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Quinoline Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
KR1020197010227A 2016-09-14 2017-09-14 약물 전달을 위한 침투 증진제를 함유하는 조성물 Withdrawn KR20190053215A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662394716P 2016-09-14 2016-09-14
US62/394,716 2016-09-14
PCT/US2017/051577 WO2018053140A1 (en) 2016-09-14 2017-09-14 Compositions with permeation enhancers for drug delivery

Publications (1)

Publication Number Publication Date
KR20190053215A true KR20190053215A (ko) 2019-05-17

Family

ID=61619716

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197010227A Withdrawn KR20190053215A (ko) 2016-09-14 2017-09-14 약물 전달을 위한 침투 증진제를 함유하는 조성물

Country Status (8)

Country Link
US (1) US20200138710A1 (enExample)
EP (1) EP3512501A4 (enExample)
JP (1) JP7277360B2 (enExample)
KR (1) KR20190053215A (enExample)
CN (2) CN109937033A (enExample)
AU (1) AU2017326347B2 (enExample)
CA (1) CA3036696A1 (enExample)
WO (1) WO2018053140A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1252531A1 (zh) 2015-08-05 2019-05-31 Children's Medical Center Corporation 用於药物递送的具有渗透增强剂的组合物
US20230270749A1 (en) * 2020-08-03 2023-08-31 Children's Medical Center Corporation Thermo-sensitive permeation enhancing formulations for drug delivery
GB202100945D0 (en) * 2021-01-25 2021-03-10 Brightcure Ltd A composition useful for treating bacterial infections
DE202021106639U1 (de) 2021-10-08 2023-01-10 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft mit beschränkter Haftung Neue Therapiekonzepte für die Behandlung von Otitis
CN117618338A (zh) * 2022-08-16 2024-03-01 海南普利制药股份有限公司 一种稳定的奥利万星药物水溶液及其制备方法
CN118518439B (zh) * 2023-02-17 2025-09-16 清华大学 离子液体制剂和组织处理方法及其应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0725628T3 (da) * 1994-08-30 2001-12-27 Alcon Lab Inc Termisk geldannende lægemiddelindgivelsesvehikler indeholdende celluloseethere
EP1109563A4 (en) * 1998-08-04 2009-07-22 Madash Llp AT THE END MODIFIED HYDROGELE WITH TEMPERATURE DEPENDENT FEATURES
EP1609468A3 (en) * 2000-11-22 2006-01-25 Rxkinetix, Inc. A composition on the basis of a sulfur-containing antioxidant and its use for the manufacture of a medicament for treating mucositis
US7220431B2 (en) * 2002-11-27 2007-05-22 Regents Of The University Of Minnesota Methods and compositions for applying pharmacologic agents to the ear
US9056061B2 (en) * 2005-09-23 2015-06-16 Alza Corporation Transdermal nicotine salt delivery system
WO2009142719A2 (en) * 2008-05-19 2009-11-26 Massachusetts Institute Of Technology Tympanic membrane permeating ear drops and uses thereof
CA2732686C (en) * 2008-12-22 2017-10-03 Otonomy, Inc. Controlled release auris sensory cell modulator compositions and methods for the treatment of otic disorders
HK1252531A1 (zh) * 2015-08-05 2019-05-31 Children's Medical Center Corporation 用於药物递送的具有渗透增强剂的组合物

Also Published As

Publication number Publication date
AU2017326347B2 (en) 2023-07-20
JP2019533644A (ja) 2019-11-21
CA3036696A1 (en) 2018-03-22
WO2018053140A1 (en) 2018-03-22
US20200138710A1 (en) 2020-05-07
EP3512501A1 (en) 2019-07-24
AU2017326347A1 (en) 2019-03-21
CN109937033A (zh) 2019-06-25
JP7277360B2 (ja) 2023-05-18
EP3512501A4 (en) 2020-04-29
CN120392650A (zh) 2025-08-01

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20190410

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination