KR20190047179A - Wound dressings applicable for laser treatment and medical device for producing wound dressing thereof - Google Patents
Wound dressings applicable for laser treatment and medical device for producing wound dressing thereof Download PDFInfo
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- KR20190047179A KR20190047179A KR1020170140721A KR20170140721A KR20190047179A KR 20190047179 A KR20190047179 A KR 20190047179A KR 1020170140721 A KR1020170140721 A KR 1020170140721A KR 20170140721 A KR20170140721 A KR 20170140721A KR 20190047179 A KR20190047179 A KR 20190047179A
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- wound dressing
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- laser treatment
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Abstract
Description
본 발명은 환부에 불투명 창상피복재가 첨부된 경우에도 환부의 레이저 치료(조사)가 가능한 창상피복재 및 이를 제조하기 위한 의료용 삽입기구에 관한 것으로, 불투명 창상피복재의 일 부분에 광학적 투명성이 부여됨으로써 상기 부분을 통해 레이저 조사가 가능한 창상피복재 및 이의 제조 기구에 관한 것이다.The present invention relates to a wound dressing material capable of laser treatment (irradiation) of a diseased part even when the opaque wound dressing is attached to the affected part, and a medical insertion instrument for manufacturing the wound dressing material, wherein a part of the opaque wound dressing is given optical transparency, And a mechanism for manufacturing the wound dressing.
화상, 외상, 창상, 욕창 등과 같은 피부 상처의 종래 치료 방법으로는 창상에 소독약을 도포하고, 거즈, 솜과 같은 흡수성 재료를 이용하여 창상 부위를 덮어 창상에서 발생되는 삼출액을 흡수하여 상처 부위를 건조시키는 방법으로 치료하였으나, 근래 연구 결과로는 창상 부위에 적당한 습윤환경이 유지되는 것이 오히려 창상 치료에 효과적임이 밝혀지면서 다양한 형태, 재료의 창상피복재들이 개발되어 시판되고 있다.Conventional treatment methods for skin wounds such as burns, trauma, wounds and pressure ulcers include applying a disinfectant to the wounds and covering the wound area using absorbent materials such as gauze and cotton to absorb the exudates generated from the wound to dry the wound area However, recent studies have shown that proper wetting conditions on the wound area are effective for wound healing, and wound dressings of various shapes and materials have been developed and marketed.
일반적으로 창상피복재에는 습윤 유지, 흡수성, 방수성, 통기성, 감염방지, 점착성, 탄성, 기계적 강도 등 다양한 물성이 요구된다.Generally, wound dressings are required to have various properties such as wetting, absorbing, waterproof, breathable, infectious, sticky, elastic, and mechanical strength.
이러한 창상피복재의 형태로는 필름형, 폼형, 부직포형, 이들의 복합형 등이 있으며, 창상피복재의 재료로는 폴리우레탄 필름, 폴리우레탄 폼, 하이드로콜로이드, 하이드로겔, 소듐알지네이트 겔, 콜라겐, 실리콘, 생체적합성 고분자 등이 이용되고 있다. 한편, 깊은 화상, 외상, 당뇨병성 족부궤양과 같은 피부 결손의 치료를 위하여 인공진피 이식을 통한 피부 재건이 요구되기도 한다. 창상피복재의 한 종류인 이러한 인공진피 제품은 외부층은 실리콘으로 구성하여 체액 증발을 막고, 내부층은 콜라겐으로 구성하여 새로운 혈관과 결합조직의 재생을 유도하는 것으로서, IntegraTM(미국, Lifesciences사), TerudermisTM(일본, Olympus Terumo Biomaterial사), PelnacTM(일본, Gunze사), MatridermTM(독일, Skin Health, Billerbeck사) 등의 있으며, 동종 진피제품에는 인체피부 조직으로부터 면역반응을 일으키는 표피 및 진피세포를 제거한 후 글라이세롤(glycerol-preserved)처리나, 동결시킨 진피조직으로 AllodermTM(미국, Life Cell사) 및 SuredermTM(한국, 한스바이오매드) 등이 있다.Examples of such wound dressings include film, foam, nonwoven, and composite types. Examples of the material of the wound dressing include polyurethane film, polyurethane foam, hydrocolloid, hydrogel, sodium alginate gel, collagen, silicone , Biocompatible polymers, and the like. On the other hand, skin reconstruction through artificial dermis transplantation may be required for treating skin defects such as deep burns, trauma, and diabetic foot ulcers. This artificial dermis product, which is a kind of wound dressing, is composed of silicone as outer layer to prevent evaporation of body fluids and inner layer as collagen to induce regeneration of new blood vessels and connective tissues. Integra ™ (Lifesciences, USA) , Terudermis TM (Japan, Olympus Terumo Biomaterial), Pelnac TM (Japan, Gunze), Matriderm TM (Germany, Skin Health, Billerbeck), and the like dermis products include epidermis Alloderm ™ (Life Cell, USA) and Surederm ™ (Korea, Hans Biomed) are the glycerol-preserved or frozen dermal tissue after removal of dermal cells.
한편, 창상피복재와 별도로, 창상 치료에 있어서 최근 광선요법이 주목받고 있다. 광선요법이란 다양한 광원을 이용하여 피부 내의 생화학적 반응을 촉진하는 방법으로, 한의학 분야에서도 광범위하게 레이저 치료가 이용되는 데, 치료 형태에 따라 레이저 침(laser acupuncture), 경근레이저, 경피레이저, 또는 오관레이저 등으로 나뉘어 불리기도 한다.On the other hand, apart from the wound dressing, recent light therapy has attracted attention in the treatment of wound healing. Phototherapy is a method of promoting biochemical reactions in the skin by using various light sources. In the field of Oriental medicine, laser treatment is widely used. Depending on the treatment type, laser acupuncture, excimer laser, percutaneous laser, It is sometimes called a laser.
이러한 레이저 침은 손상된 피부조직의 콜라겐 합성을 증가시키고 염증을 감소시키는 등 피부 결손의 재건과정에 중요한 요소들의 기능을 회복하는데 도움을 주는 것으로 알려져 있다. 레이저 침을 비롯한 다양한 레이저 치료요법에서는 다양한 파장에 따라 세포와 피부조직에 투과 정도가 다른 것으로 알려져 있다. 실제 인체 피부조직을 대상으로 한 연구에서 400 nm 파장은 1 mm 이하의 투과력을 나타내는 반면, 700 ~ 900 nm 의 경우는 진피층까지 투과하는 것으로 알려져 있다. 임상 연구들에 따르면, 당뇨병성 궤양에 630 ~ 980 nm 의 다양한 레이저 파장이 사용되고 있다.These laser irons are known to help restore function of critical factors in the reconstruction process of skin defects, such as increasing collagen synthesis in injured skin tissue and reducing inflammation. Various laser therapies, including laser irons, are known to have different degrees of transmission to cells and skin tissues at various wavelengths. In a study of actual human skin tissue, it is known that 400 nm wavelength shows penetration below 1 mm, while 700 ~ 900 nm penetrates to the dermal layer. Clinical studies have shown that diabetic ulcers use a variety of laser wavelengths from 630 to 980 nm.
이러한 레이저 치료에 있어서, 그 치료 효과는 레이저의 파장 뿐 아니라 중간 매체의 광학적 투명성에 큰 영향을 받는 것으로 알려져 있다. 즉, 레이저가 투과되는 중간 매체의 광투과도가 매우 중요한 요소인 데, 불투명한 창상피복재와 병용하는 경우 레이저 투과도가 낮아 충분한 레이저 치료 효과를 발휘할 수 없는 문제가 발생한다.In such a laser treatment, its therapeutic effect is known to be greatly influenced not only by the wavelength of the laser but also by the optical transparency of the intermediate medium. That is, the light transmittance of the intermediate medium through which the laser is transmitted is a very important factor. When used in combination with an opaque wound dressing, the laser transmittance is low and a sufficient laser treatment effect can not be exhibited.
통상적으로 창상피복재는 환부의 관찰을 위해 투명한 재질로 제조되기도 하나, 환부에 대한 시각적 혐오감, 불투명한 재료의 사용 또는 여러 재료들의 다층 구조로 인해 피부색이나 백색 등과 같은 불투명으로 제조되기도 한다. 이렇게 창상피복재가 불투명한 경우, 또는 두께가 있는 경우에는 레이저 치료의 병용 치료가 불가능하거나 어려운 문제점이 있다.Typically, wound dressings are made of a transparent material for the observation of the lesion, but may also be made opaque, such as skin color or white due to the visual disgust of the lesion, the use of opaque materials, or the multi-layer structure of various materials. When the wound dressing is opaque or thick, there is a problem that it is difficult or impossible to treat with laser treatment.
본 발명은 상술한 문제점을 해결하기 위한 것으로, 시판되는 불투명한 창상피복재를 이용하여 시술자가 원하는 창상피복재 위치에 투명성을 부여함으로써, 투명한 부분을 통해 레이저 치료(조사)가 가능하도록 하여, 치료의 효과를 높일 수 있는 창상피복재와, 이러한 창상피복재를 제조하는 데 이용되는 투명 부재 삽입을 위한 의료용 삽입기구를 제공하는 데 그 목적이 있다.Disclosure of Invention Technical Problem [8] The present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide an opaque wound dressing which is commercially available to impart transparency to a position of a wound dressing material desired by a practitioner, And a medical insertion device for inserting a transparent member used for manufacturing such a wound dressing.
본 발명은 불투명 창상피복재 상에 레이저 치료가 가능하도록 창상피복재의 일부분에 투명성을 부여하기 위하여 투명 부재를 삽입하는 삽입기구로서, 상기 삽입기구는 투명 부재가 내장되어 있는 중공성 니들과, 상기 니들을 지지하는 실린더와, 상기 실린더 내에 구비되는 플런저를 포함하고, 상기 투명 부재는 투명 생체적합성 고분자가 코어를 이루고, 상기 코어 외부에는 수팽윤성 고분자층이 형성된 구조로서, 상기 투명 부재의 창상피복재 관통 삽입된 후, 상기 수팽윤성 고분자층의 팽창에 의해 상기 투명 생체적합성 고분자가 창상피복재에 견고하게 고정되는 것을 특징으로 하는, 레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구를 제공한다.The present invention relates to an insertion mechanism for inserting a transparent member to impart transparency to a part of a wound dressing so as to enable laser treatment on an opaque wound dressing, the insertion mechanism including a hollow needle having a transparent member embedded therein, And a plunger provided in the cylinder, wherein the transparent member has a structure in which a transparent biocompatible polymer forms a core and a water-swellable polymer layer is formed outside the core, Wherein the transparent biocompatible polymer is firmly fixed to the wound dressing material by swelling of the water-swellable polymer layer.
상기 수팽윤성 고분자는 전분, 한천과 같은 공지된 천연 수팽윤성 고분자, 카르복시메틸 셀룰로즈(CMC)계, 전분 및 셀룰로즈에 석유화합물인 친수성 합성고분자를 결합시킨 반합성 가교 고분자, 수용성 합성고분자(폴리아크릴산, 폴리비닐알콜 등)의 가교물, 에스테르화된 카르복실기 함유 다당류와 천연 아미노산에서 유래하는 α-아미노기를 2 개 이상 갖는 화합물을 반응시킨 합성 고분자와, 수산기(-OH), 카르복실산기(-COOH), 아미드기(-CONH), 카르복실산염기, 술폰산염기를 가지는 친수성 기능기와 소수성 사슬이 가교된 고흡수성 고분자로 이루어진 군에서 선택될 수 있다.The water-swellable polymer may be a known natural water-swellable polymer such as starch and agar, a semisynthetic crosslinked polymer obtained by bonding a hydrophilic synthetic polymer such as carboxymethyl cellulose (CMC), starch and cellulose to a petroleum compound, a water-soluble synthetic polymer (polyacrylic acid, poly Vinyl alcohol and the like), a synthetic polymer obtained by reacting an esterified carboxyl group-containing polysaccharide with a compound having two or more? -Amino groups derived from a natural amino acid and a hydroxyl group (-OH), a carboxylic acid group (-COOH) A hydrophilic functional group having an amide group (-CONH), a carboxylic acid group or a sulfonic acid group, and a superabsorbent polymer crosslinked with a hydrophobic chain.
상기 투명 생체적합성 고분자는 상기 생체적합성 고분자는 히알루론산(hyaluronicacid; HA), 젤라틴(gelatin), 키토산(chitosan), 콜라겐(collagen), 알긴산, 펙틴, 카라기난, 콘드로이틴(설페이트), 덱스트란(설페이트), 폴리라이신(polylysine), 카르복시메틸티틴, 피브린, 아가로스, 풀루란, 셀룰로오스, 폴리비닐피롤리돈(PVP), 폴리에틸렌글리콜(PEG), 폴리비닐알콜(PVA), 히드록시프로필셀룰로스(HPC), 히드록시에틸셀룰로스(HEC), 히드록시프로필메틸셀룰로스(HPMC), 나트륨카르복시메틸셀룰로스, 폴리알콜, 아라비아검, 알기네이트, 시클로덱스트린, 덱스트린, 포도당, 과당, 녹말, 트레할로스, 글루코스, 말토스, 락토스, 락툴로스, 프럭토스, 투라노스, 멜리토스, 멜레지토스, 덱스트란, 소르비톨, 크실리톨, 팔라티니트, 폴리락트산(polylactic acid), 폴리글리콜산(polyglycolic acid), 폴리에틸렌옥사이드, 폴리아크릴산, 폴리아크릴아마이드, 폴리메타아크릴산 및 폴리말레인산으로 구성된 군에서 선택될 수 있다.The biocompatible polymer may be selected from the group consisting of hyaluronic acid (HA), gelatin, chitosan, collagen, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate) Polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropylcellulose (HPC), polyvinylpyrrolidone , Hydroxyethylcellulose (HEC), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose, polyalcohol, gum arabic, alginate, cyclodextrin, dextrin, glucose, fructose, starch, trehalose, glucose, maltose, But are not limited to, lactose, lactulose, fructose, turanose, melitose, melitose, dextran, sorbitol, xylitol, palatinite, polylactic acid, polyglycolic acid, Polyethylene oxide, polyacrylic acid, polyacrylamide, polymethacrylic acid and polymaleic acid.
상기 투명 부재는 단편 조각 형태로 중공성 니들에 순차적으로 장착되어 별도의 절단없이 창상피복재에 삽입고정되는 구조가 가능하다.The transparent member may be sequentially mounted on the hollow needle in the form of a piece of piece, and may be inserted and fixed in the wound dressing without separate cutting.
상기 투명 부재의 직경은 1 ~ 5 mm 의 범위에서 이루어지는 것이 바람직하다.The diameter of the transparent member is preferably in the range of 1 to 5 mm.
한편 본 발명은 불투명 창상피복재의 일부분에 투명 생체적합성 고분자가 코어를 이루고, 상기 코어 외부에는 수팽윤성 고분자층이 형성된 상기 투명 부재가 관통 삽입되어 있고, 상기 수팽윤성 고분자층의 팽창에 의해 상기 투명 생체적합성 고분자가 창상피복재에 견고하게 고정되어 있는 것을 특징으로 하는, 레이저 치료가 가능한 창상피복재를 제공한다.The present invention also provides a transparent biocompatible polymer, wherein the transparent biocompatible polymer core is formed on a part of the opaque wound dressing material, the transparent member having a water swellable polymer layer formed on the outside of the core is inserted and penetrated, Provided is a wound dressing capable of laser treatment, characterized in that the conformable polymer is firmly fixed to the wound dressing.
본 발명에 따른 창상피복재와 이의 제조에 이용되는 의료용 삽입기구는 시판되는 불투명한 창상피복재를 이용하여 창상피복재 일 부분에 투명 생체적합성 고분자를 효과적으로 삽입, 견고히 고정함으로써, 창상피복과 레이저 치료의 병용이 가능하여 창상 치료 효과를 증가시킬 수 있는 장점을 가진다.The wound dressing according to the present invention and the medical insertion device used for its manufacture can be effectively combined with a commercially available opaque wound dressing to effectively insert and securely fix a transparent biocompatible polymer to a part of the wound dressing so that a combination of wound dressing and laser treatment And thus has the advantage of increasing the wound treatment effect.
도 1은 본 발명의 일시예에 따라 다양한 모양, 형태의 투명 부재가 형성된 창상피복재의 구조를 나타내는 도이다.
도 2는 본 발명의 수팽창성 고분자층의 팽창을 나타내는 단면도이다.
도 3는 본 발명의 일 실시예에 따른 투명 부재 삽입기구의 체결 사시도이다.
도 4는 본 발명에 따라 투명 부재(2,3)의 단편 조각들이 니들에 연속적으로 장착됨을 나타내는 도이다.1 is a view showing the structure of a wound dressing material in which transparent members of various shapes and shapes are formed according to a temporary example of the present invention.
2 is a cross-sectional view showing expansion of the water-swellable polymer layer of the present invention.
3 is a perspective view of the fastening mechanism of the transparent member insertion mechanism according to an embodiment of the present invention.
Fig. 4 is a view showing that fragment pieces of the
본 발명자는 시판되는 창상피복재가 불투명한 경우, 환부에 창상피복재의 첩부 후에 레이저 치료의 효과가 없거나 낮은 것을 확인하고, 이러한 문제점을 해결하기 위하여 불투명한 창상피복재의 레이저 조사할 부분에 투명 부재를 삽입함으로써 광학적 투명성을 부여하는 한편, 투명 부재의 이탈에 따른 외부 감염을 방지하고기 위해 투명 부재를 창상피복재에 견고히 밀봉고정시킬 수 있는 방법을 개발하여 본 발명을 완성하였다.The present inventors have found that when a commercially available wound dressing is opaque, there is no or low effect of laser treatment after application of the wound dressing to the affected area. In order to solve such a problem, a transparent member is inserted into a part of the opaque wound dressing To thereby provide optical transparency and to securely seal the transparent member to the wound covering material in order to prevent external infections caused by the separation of the transparent member, thereby completing the present invention.
본 발명은 불투명 창상피복재의 일부분에 투명 생체적합성 고분자가 코어를 이루고, 상기 코어 외부에는 수팽윤성 고분자층이 형성된 상기 투명 부재가 관통 삽입되어 있고, 상기 수팽윤성 고분자층의 팽창에 의해 상기 투명 생체적합성 고분자가 창상피복재에 견고하게 고정되어 있는 것을 특징으로 하는, 레이저 치료가 가능한 창상피복재를 제공한다.The present invention provides a transparent biocompatible polymer comprising a transparent biocompatible polymer core formed on a part of an opaque wound dressing and a transparent member having a water swellable polymer layer formed on the outside of the core, Provided is a wound dressing capable of laser treatment, characterized in that the polymer is firmly fixed to the wound dressing.
한편, 본 발명은 레이저 시술자가 불투명 창상피복재의 원하는 부분에 상기 투명 부재를 용이하게 삽입할 수 있는 의료용 삽입기구를 제공한다.Meanwhile, the present invention provides a medical insertion device in which a laser operator can easily insert the transparent member into a desired portion of the opaque wound dressing.
이하 도면을 통하여 본 발명을 상세히 설명한다.BEST MODE FOR CARRYING OUT THE INVENTION The present invention will be described in detail with reference to the drawings.
도 1은 본 발명의 일시예에 따른 창상피복재의 구조를 나타낸다.1 shows the structure of a wound dressing according to a temporary example of the present invention.
본 발명의 창상피복재는 전체적으로는 불투명 창상피복재(1)로 이루어지며, 일 부분에는 투명 부재(2,3)가 창상피복재를 수직으로 관통하여 삽입되어 결속된 구조를 가진다. 상기 투명 부재는 투명 생체적합성 고분자(2)가 코어를 이루고, 상기 코어 외부에는 수팽윤성 고분자층(3)이 형성된 구조로서, 창상피복재의 수분 또는 환부의 수분 또는 삼출액에 의해 수팽윤성 고분자층(3)이 도 2에 도시된 바와 같이 팽창됨으로써 불투명 창상피복재(1) 속에 투명 생체적합성 고분자(2)가 견고하게 고정됨으로써, 외부 충격 또는 활동에 의해 투명 생체적합성 고분자(2)가 이탈되는 것을 방지하여, 외부 감염 가능성을 차단하게 된다.The wound covering material of the present invention is composed entirely of an opaque wound covering material 1, and a transparent material (2, 3) has a structure in which a wound covering material is vertically penetrated and bound by a part of the covering material. The transparent member is a structure in which a transparent biocompatible polymer (2) forms a core, and a water-swellable polymer layer (3) is formed on the outside of the core. The water-swellable polymer layer Is expanded as shown in FIG. 2 to firmly fix the transparent
본 발명에 따른 창상피복재는 공장에서 일련의 공정으로 제조된 후 시판될 수 있으나, 의사와 같은 시술자가 종래 시판되는 불투명 창상피복재를 구입 후 본 발명에 따른 의료용 삽입기구를 이용하여 도 1에 도시된 바와 같이 시술자가 원하는 위치에 다양하게 삽입할 수 있고, 삽입되는 투명 재질(2)의 직경, 삽입 개수를 조절할 수 있다.The wound dressing according to the present invention may be manufactured in a series of processes in the factory and then marketed. However, when a practitioner such as a physician purchases a conventional opaque wound dressing material and then uses the medical insertion device according to the present invention, The operator can variously insert the
시술자는 창상피복재를 환부에 첨부한 다음, 상기와 같이 형성된 투명 생체적합성 고분자 부분을 통하여 레이저 투과의 장애없이 환부에 레이저를 조사함으로써 환부의 피부 조직을 자극하여 피부 재생의 효과를 극대화 시킬 수 있다.The practitioner can attach the wound dressing material to the affected part and then irradiate laser to the affected part through the transparent biocompatible polymer part formed as described above without laser interference, thereby maximizing the skin regeneration effect by stimulating the skin tissue of the affected part.
본 발명에 따른 수팽윤성 고분자(2)는 물을 흡수하여 팽창되고 겔(gel)화되어 다소의 압력을 받아도 물을 방출하지 않는 특성을 갖는 고분자로, 본 발명에 따른 수팽윤성 고분자(2)로는 전분, 한천과 같은 공지된 천연 재료들, 카르복시메틸 셀룰로즈(CMC)계, 전분 및 셀룰로즈에 석유화합물인 친수성(親水性) 합성고분자를 결합시킨 반합성 가교 고분자 및 수용성 합성고분자(폴리아크릴산, 폴리비닐알콜 등)의 가교물, 에스테르화된 카르복실기 함유 다당류와 천연 아미노산에서 유래하는 α-아미노기를 2 개 이상 갖는 화합물을 반응시킨 합성 고분자와, 수산기(-OH), 카르복실산기(-COOH), 아미드기(-CONH), 카르복실산염기, 술폰산염기를 가지는 친수성 기능기와 소수성 사슬이 가교된 고흡수성 고분자를 이용될 수 있으나 이에 제한되지는 않는다.The water-swellable polymer (2) according to the present invention is a polymer having a property of absorbing water to be swollen and geled and not releasing water even under a slight pressure. The water-swellable polymer (2) Known synthetic polymers such as starch and agar, semisynthetic crosslinked polymers obtained by binding carboxymethylcellulose (CMC), starch and cellulose with a hydrophilic synthetic polymer as a petroleum compound, and water-soluble synthetic polymers such as polyacrylic acid, polyvinyl alcohol (-OH), a carboxylic acid group (-COOH), an amide group (-COOH), and the like, and a synthetic polymer obtained by reacting an esterified carboxyl group-containing polysaccharide with a compound having two or more? (-CONH), a carboxylic acid group, or a hydrophilic functional group having a sulfonic acid group and a hydrophobic chain, may be used, but the present invention is not limited thereto.
본 발명에 따른 투명 생체적합성 고분자는 인체 조직에 거부 반응이 없는 재료이면 그 사용에 제한이 없으나, 히알루론산(hyaluronicacid; HA), 젤라틴(gelatin), 키토산(chitosan), 콜라겐(collagen), 알긴산, 펙틴, 카라기난, 콘드로이틴(설페이트), 덱스트란(설페이트), 폴리라이신(polylysine), 카르복시메틸티틴, 피브린, 아가로스, 풀루란, 셀룰로오스, 폴리비닐피롤리돈(PVP), 폴리에틸렌글리콜(PEG), 폴리비닐알콜(PVA), 히드록시프로필셀룰로스(HPC), 히드록시에틸셀룰로스(HEC), 히드록시프로필메틸셀룰로스(HPMC), 나트륨카르복시메틸셀룰로스, 폴리알콜, 아라비아검, 알기네이트, 시클로덱스트린, 덱스트린, 포도당, 과당, 녹말, 트레할로스, 글루코스, 말토스, 락토스, 락툴로스, 프럭토스, 투라노스, 멜리토스, 멜레지토스, 덱스트란, 소르비톨, 크실리톨, 팔라티니트, 폴리락트산(polylactic acid), 폴리글리콜산(polyglycolic acid), 폴리에틸렌옥사이드, 폴리아크릴산, 폴리아크릴아마이드, 폴리메타아크릴산 및 폴리말레인산으로 구성된 군에서 선택된 것이 바람직하다.The transparent biocompatible polymer according to the present invention is not limited in its use as long as it does not have a rejection reaction to human tissues. However, it is not limited to hyaluronic acid (HA), gelatin, chitosan, collagen, (PVP), polyethylene glycol (PEG), polyethylene glycol (PEG), polyvinylpyrrolidone (PEG), carboxymethylcellulose Polyvinyl alcohol (PVA), hydroxypropylcellulose (HPC), hydroxyethylcellulose (HEC), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose, polyalcohol, gum arabic, alginate, cyclodextrin, dextrin , Fructose, starch, trehalose, glucose, maltose, lactose, lactulose, fructose, turanose, melitose, melitose, dextran, sorbitol, xylitol, palatinite, poly It is preferably selected from the group consisting of polylactic acid, polyglycolic acid, polyethylene oxide, polyacrylic acid, polyacrylamide, polymethacrylic acid and polymaleic acid.
본 발명은 불투명 창상피복재 상에 레이저 치료가 가능하도록 창상피복재의 일부분에 투명성을 부여하기 위하여 투명 부재를 삽입하는 삽입기구를 제공한다.The present invention provides an insertion mechanism for inserting a transparent member to impart transparency to a portion of a wound dressing material so that laser treatment is possible on the opaque wound dressing material.
도 3는 본 발명의 일 실시예에 따른 투명 부재 삽입기구의 체결 사시도이다.3 is a perspective view of the fastening mechanism of the transparent member insertion mechanism according to an embodiment of the present invention.
도 3을 참조하면, 본 발명에 따른 상기 삽입기구(10)는 투명 부재(2,3)가 내장되어 있는 중공성 니들(11)과, 상기 니들(11)을 지지하는 실린더(12)와, 상기 실린더 내에 구비되는 플런저(13)를 포함하여 이루어 진다.3, the
상기 중공성 니들(11)은 나사모양의 체결수단 등을 통하여 실린터(12)에 직접 결합될 수 있으나, 도 3에 보이는 바와 같이 니들(11)은 니들 고정부재(14)에 삽입되어 지지되고, 상기 니들 고정부재(14)가 실린터에 체결되는 것이 가능하다.상기 투명 부재(2,3)가 삽입 장착된 니들 고정부재(14)는 일종의 카트리지로서, 카트리지를 교환 방식으로 재사용이 가능하다.The
상기 플런저(13)는 실린더(12)에 삽입되고, 플런저(13)의 앞부분이 니들 고정부재(14)를 통해 니들에 밀착된 후, 니들(11)의 창상피복재 관통 후에 니들(11) 속에 장착된 투명 부재(2,3)를 밀어냄으로서 투명 부재(2,3)는 창상피복재에 삽입된다. The
투명 부재(2,3)의 창상피복재 관통 삽입 후에 칼, 가위와 같은 절단도구를 이용하여 창상피복재 양면의 투명 부재(2,3)를 절단함으로써 투명 부재(2,3)의 창상피복재 삽입은 완료된다.After inserting the transparent members (2, 3) through the wound dressing, the transparent members (2, 3) on both sides of the wound dressing are cut using a cutting tool such as a knife or scissors to complete the insertion of the wound dressing do.
한편, 중공성 니들(11)에 장착된 투명 부재(2,3)는 실과 같은 연결된 모양이 아닌, 일련의 단편 조각들이 니들에 연속적으로 배열, 장착된 형태도 가능하다. 이러한 구조는 창상피복재에 투명 부재(2,3) 삽입 후 별도의 절단과정이 필요없으므로 보다 원활한 투명 부재의 삽입을 가능케 한다.On the other hand, the transparent members (2, 3) mounted on the hollow needle (11) can be configured such that a series of pieces of fragments are continuously arranged and mounted on the needles, This structure makes it possible to insert a transparent member more smoothly since no separate cutting process is required after inserting the transparent member (2, 3) into the wound dressing.
1: 불투명 창상피복재
2: 투명 생체적합성 고분자
3: 수팽창성 고분자층
2,3: 투명 부재
10: 투명 부재 삽입기구
11: 중공성 니들
12: 실린더
13: 플런저1: opaque wound dressing 2: transparent biocompatible polymer
3: water-
10: transparent member insertion mechanism 11: hollow needle
12: cylinder 13: plunger
Claims (8)
상기 삽입기구는 투명 부재가 내장되어 있는 중공성 니들과, 상기 니들을 지지하는 실린더와, 상기 실린더 내에 구비되는 플런저를 포함하고,
상기 투명 부재는 투명 생체적합성 고분자가 코어를 이루고, 상기 코어 외부에는 수팽윤성 고분자층이 형성된 구조로서,
상기 투명 부재의 창상피복재 관통 삽입된 후, 상기 수팽윤성 고분자층의 팽창에 의해 상기 투명 생체적합성 고분자가 창상피복재에 견고하게 고정되는 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구.
An insertion mechanism for inserting a transparent member to impart transparency to a portion of a wound dressing material so that laser treatment is possible on the opaque wound dressing material,
Wherein the insertion mechanism includes a hollow needle having a transparent member embedded therein, a cylinder for supporting the needle, and a plunger provided in the cylinder,
The transparent member is a structure in which a transparent biocompatible polymer forms a core and a water-swellable polymer layer is formed outside the core.
Wherein the transparent biocompatible polymer is firmly fixed to the wound dressing material by swelling of the water-swellable polymer layer after the transparent member is inserted through the wound dressing material.
Medical insertion device for the manufacture of wound dressings capable of laser treatment.
상기 수팽윤성 고분자는 전분, 한천과 같은 공지된 천연 수팽윤성 고분자, 카르복시메틸 셀룰로즈(CMC)계, 전분 및 셀룰로즈에 석유화합물인 친수성 합성고분자를 결합시킨 반합성 가교 고분자, 수용성 합성고분자(폴리아크릴산, 폴리비닐알콜 등)의 가교물, 에스테르화된 카르복실기 함유 다당류와 천연 아미노산에서 유래하는 α-아미노기를 2 개 이상 갖는 화합물을 반응시킨 합성 고분자와, 수산기(-OH), 카르복실산기(-COOH), 아미드기(-CONH), 카르복실산염기, 술폰산염기를 가지는 친수성 기능기와 소수성 사슬이 가교된 고흡수성 고분자로 이루어진 군에서 선택된 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구.
The method according to claim 1,
The water-swellable polymer may be a known natural water-swellable polymer such as starch and agar, a semisynthetic crosslinked polymer obtained by bonding a hydrophilic synthetic polymer such as carboxymethyl cellulose (CMC), starch and cellulose to a petroleum compound, a water-soluble synthetic polymer (polyacrylic acid, poly Vinyl alcohol and the like), a synthetic polymer obtained by reacting an esterified carboxyl group-containing polysaccharide with a compound having two or more? -Amino groups derived from a natural amino acid and a hydroxyl group (-OH), a carboxylic acid group (-COOH) A hydrophilic functional group having an amide group (-CONH), a carboxylic acid group or a sulfonic acid group, and a superabsorbent polymer crosslinked with a hydrophobic chain.
Medical insertion device for the manufacture of wound dressings capable of laser treatment.
상기 투명 생체적합성 고분자는 상기 생체적합성 고분자는 히알루론산(hyaluronicacid; HA), 젤라틴(gelatin), 키토산(chitosan), 콜라겐(collagen), 알긴산, 펙틴, 카라기난, 콘드로이틴(설페이트), 덱스트란(설페이트), 폴리라이신(polylysine), 카르복시메틸티틴, 피브린, 아가로스, 풀루란, 셀룰로오스, 폴리비닐피롤리돈(PVP), 폴리에틸렌글리콜(PEG), 폴리비닐알콜(PVA), 히드록시프로필셀룰로스(HPC), 히드록시에틸셀룰로스(HEC), 히드록시프로필메틸셀룰로스(HPMC), 나트륨카르복시메틸셀룰로스, 폴리알콜, 아라비아검, 알기네이트, 시클로덱스트린, 덱스트린, 포도당, 과당, 녹말, 트레할로스, 글루코스, 말토스, 락토스, 락툴로스, 프럭토스, 투라노스, 멜리토스, 멜레지토스, 덱스트란, 소르비톨, 크실리톨, 팔라티니트, 폴리락트산(polylactic acid), 폴리글리콜산(polyglycolic acid), 폴리에틸렌옥사이드, 폴리아크릴산, 폴리아크릴아마이드, 폴리메타아크릴산 및 폴리말레인산으로 구성된 군에서 선택된 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구.
The method according to claim 1,
The biocompatible polymer may be selected from the group consisting of hyaluronic acid (HA), gelatin, chitosan, collagen, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate) Polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropylcellulose (HPC), polyvinylpyrrolidone , Hydroxyethylcellulose (HEC), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose, polyalcohol, gum arabic, alginate, cyclodextrin, dextrin, glucose, fructose, starch, trehalose, glucose, maltose, But are not limited to, lactose, lactulose, fructose, turanose, melitose, melitose, dextran, sorbitol, xylitol, palatinite, polylactic acid, polyglycolic acid, Polyethylene oxide, polyacrylic acid, polyacrylamide, polymethacrylic acid and polymaleic acid.
Medical insertion device for the manufacture of wound dressings capable of laser treatment.
상기 투명 부재는 단편 조각 형태로 중공성 니들에 순차적으로 장착되어 별도의 절단없이 창상피복재에 삽입고정되는 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구.
The method according to claim 1,
Characterized in that the transparent member is sequentially mounted on the hollow needle in the form of a piece of piece and is inserted and fixed into the wound dressing material without separate cutting.
Medical insertion device for the manufacture of wound dressings capable of laser treatment.
상기 투명 부재의 직경은 1 ~ 5 mm 인 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재 제조용 의료용 삽입기구.
The method according to claim 1,
Characterized in that the diameter of the transparent member is 1 to 5 mm.
Medical insertion device for the manufacture of wound dressings capable of laser treatment.
레이저 치료가 가능한 창상피복재.
Wherein the transparent biocompatible polymer has a core formed on a part of the opaque wound dressing material and the transparent member having a water swellable polymer layer formed on the outside of the core is inserted through and the transparent biocompatible polymer is wound on the water swellable polymer layer, Characterized in that it is fixed firmly to the covering material.
Wound dressing with laser treatment.
상기 수팽윤성 고분자는 전분, 한천과 같은 공지된 천연 수팽윤성 고분자, 카르복시메틸 셀룰로즈(CMC)계, 전분 및 셀룰로즈에 석유화합물인 친수성 합성고분자를 결합시킨 반합성 가교 고분자, 수용성 합성고분자(폴리아크릴산, 폴리비닐알콜 등)의 가교물, 에스테르화된 카르복실기 함유 다당류와 천연 아미노산에서 유래하는 α-아미노기를 2 개 이상 갖는 화합물을 반응시킨 합성 고분자와, 수산기(-OH), 카르복실산기(-COOH), 아미드기(-CONH), 카르복실산염기, 술폰산염기를 가지는 친수성 기능기와 소수성 사슬이 가교된 고흡수성 고분자로 이루어진 군에서 선택된 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재.
The method according to claim 6,
The water-swellable polymer may be a known natural water-swellable polymer such as starch and agar, a semisynthetic crosslinked polymer obtained by bonding a hydrophilic synthetic polymer such as carboxymethyl cellulose (CMC), starch and cellulose to a petroleum compound, a water-soluble synthetic polymer (polyacrylic acid, poly Vinyl alcohol and the like), a synthetic polymer obtained by reacting an esterified carboxyl group-containing polysaccharide with a compound having two or more? -Amino groups derived from a natural amino acid and a hydroxyl group (-OH), a carboxylic acid group (-COOH) A hydrophilic functional group having an amide group (-CONH), a carboxylic acid group or a sulfonic acid group, and a superabsorbent polymer crosslinked with a hydrophobic chain.
Wound dressing with laser treatment.
상기 투명 생체적합성 고분자는 상기 생체적합성 고분자는 히알루론산(hyaluronicacid; HA), 젤라틴(gelatin), 키토산(chitosan), 콜라겐(collagen), 알긴산, 펙틴, 카라기난, 콘드로이틴(설페이트), 덱스트란(설페이트), 폴리라이신(polylysine), 카르복시메틸티틴, 피브린, 아가로스, 풀루란, 셀룰로오스, 폴리비닐피롤리돈(PVP), 폴리에틸렌글리콜(PEG), 폴리비닐알콜(PVA), 히드록시프로필셀룰로스(HPC), 히드록시에틸셀룰로스(HEC), 히드록시프로필메틸셀룰로스(HPMC), 나트륨카르복시메틸셀룰로스, 폴리알콜, 아라비아검, 알기네이트, 시클로덱스트린, 덱스트린, 포도당, 과당, 녹말, 트레할로스, 글루코스, 말토스, 락토스, 락툴로스, 프럭토스, 투라노스, 멜리토스, 멜레지토스, 덱스트란, 소르비톨, 크실리톨, 팔라티니트, 폴리락트산(polylactic acid), 폴리글리콜산(polyglycolic acid), 폴리에틸렌옥사이드, 폴리아크릴산, 폴리아크릴아마이드, 폴리메타아크릴산 및 폴리말레인산으로 구성된 군에서 선택된 것을 특징으로 하는,
레이저 치료가 가능한 창상피복재.The method according to claim 6,
The biocompatible polymer may be selected from the group consisting of hyaluronic acid (HA), gelatin, chitosan, collagen, alginic acid, pectin, carrageenan, chondroitin (sulfate), dextran (sulfate) Polyvinylpyrrolidone (PVP), polyethylene glycol (PEG), polyvinyl alcohol (PVA), hydroxypropylcellulose (HPC), polyvinylpyrrolidone , Hydroxyethylcellulose (HEC), hydroxypropylmethylcellulose (HPMC), sodium carboxymethylcellulose, polyalcohol, gum arabic, alginate, cyclodextrin, dextrin, glucose, fructose, starch, trehalose, glucose, maltose, But are not limited to, lactose, lactulose, fructose, turanose, melitose, melitose, dextran, sorbitol, xylitol, palatinite, polylactic acid, polyglycolic acid, Polyethylene oxide, polyacrylic acid, polyacrylamide, polymethacrylic acid and polymaleic acid.
Wound dressing with laser treatment.
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000060980A (en) * | 1998-08-17 | 2000-02-29 | Ya Man Ltd | Laser treatment method |
| JP2007275185A (en) * | 2006-04-04 | 2007-10-25 | Nakajima Kogyo:Kk | Wound protecting dressing |
| JP2010500076A (en) * | 2006-08-07 | 2010-01-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Plaster and radiation system |
| KR101225135B1 (en) * | 2011-06-13 | 2013-01-22 | 주식회사 칼라세븐 | Rechargeable patch for color light therapy |
| US20160000609A1 (en) * | 2011-11-17 | 2016-01-07 | Ethicon, Inc. | Dressing device |
| KR20170028782A (en) * | 2015-09-04 | 2017-03-14 | 엘지이노텍 주식회사 | Patch type thermometer by measuring infrared rays |
-
2017
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2000060980A (en) * | 1998-08-17 | 2000-02-29 | Ya Man Ltd | Laser treatment method |
| JP2007275185A (en) * | 2006-04-04 | 2007-10-25 | Nakajima Kogyo:Kk | Wound protecting dressing |
| JP2010500076A (en) * | 2006-08-07 | 2010-01-07 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | Plaster and radiation system |
| KR101225135B1 (en) * | 2011-06-13 | 2013-01-22 | 주식회사 칼라세븐 | Rechargeable patch for color light therapy |
| US20160000609A1 (en) * | 2011-11-17 | 2016-01-07 | Ethicon, Inc. | Dressing device |
| KR20170028782A (en) * | 2015-09-04 | 2017-03-14 | 엘지이노텍 주식회사 | Patch type thermometer by measuring infrared rays |
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