RU2339399C2 - Method for treatment of wounds of soft tissues - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention concerns medicine, namely treatment of wounds of soft tissues. For this purpose apply gel Kollapan on a traumatic surface in amount of 1 ml on 8-12 cm². The way provides expansion of an arsenal of agents for treatment of wounds, by optimisation of reparative processes at healing of superficial and deep damages of soft tissues.

EFFECT: expansion of arsenal of agents for treatment of wounds, by optimisation of reparative processes at healing of superficial and deep damages of soft tissues.

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Description

The method relates to medicine, namely to the treatment of superficial and deep wounds of soft tissues.

A large number of agents for treating soft tissue wounds, such as panthenol, are known, but all of them are intended for treating superficial wounds.

Known biocomposite drug KollapAn (Biomaterials, 2006, No. 5, Information publication for traumatologists and orthopedists). CollapAn consists of hydroxyappatite, collagen and an antibiotic. An antibiotic (any one of the customer’s choice) is structurally part of the drug. This makes it possible to release an antibiotic into the wound as collagen breaks up with a high concentration of the antibiotic in the wound for three weeks. Hydroxyappatite, which is part of the drug, is structurally distributed in a matrix of highly purified collagen, which allows us to consider the drug as an analogue of the structure of bone tissue. In addition, the drug has sorption properties.

CollapAn was created and is used as an osteogenic substance to activate reparative processes in bone tissue. For example, extensive bone defects are filled with KollapAn granules after eliminating foci of primary chronic osteomyelitis, etc. CollapAn is also available in the form of a gel for puncture injection into the bone cavity.

The experience of using KollapAn has shown that such a combination of its properties allows us to expand the scope of its application. It turned out that CollapAn actively promotes the healing of wound surfaces, including granulating wounds (in the complete absence of dermis), which was proved in clinical trials.

Mode of application.

The drug is applied to the wound surface in an amount of 1 ml per 8-12 cm ² . A dressing is not necessary. For superficial wounds, a single use is possible. For deep wounds (by analogy with burns of the III B degree), wounds are treated a second time.

Clinical example.

Patient B.A.V., 67 years old, and / b No. 10263, intensive care unit 7 GKB. Diagnosis: combined trauma, brain contusion, open fracture of the right thigh in s / 3, open fracture of the bones of the left lower leg in s / 3, shock III. To stabilize the state, primary surgical treatment of wounds of the lower leg and thigh, and osteosynthesis of the thigh and lower leg were performed. On the 3rd day, suppuration of the wound of the left lower leg was noted. The wound is disclosed, a small amount of purulent discharge is released. The wound is washed with hydrogen peroxide. CollapAn gel with cefazolin was introduced into the wound. Over the next three days, the wound cleared. On the 8th day, granulations appeared. Reapplying CollapAn to the wound. As it dries for an hour, the gel compacts and closes the wound with a dense whitish crust, under which the wound is epithelized as under a natural scab. The latter after epithelization disappears.

The technical result of the application of the proposed method is the quick and reliable healing of soft tissue damage due to the presence of collagen and hydroxyappatite in the preparation, which imparts reparative and sorption properties to the preparation. The prolonged action of the antibiotic is an important factor in preventing the development of infection in the wound.

Claims (1)

A method of treating soft tissue wounds by applying the CollapAn gel on wound surfaces in an amount of 1 ml per 8-12 cm ² .