KR20190035253A - Microneedle tip cutter for pharmaceutical analysis of microneedles - Google Patents

Abstract

The present invention relates to a microneedle tip cutter for a pharmaceutical analysis, and more specifically, to a microneedle tip cutter which can precisely cut a microneedle tip corresponding to a protruding length thereof in order to check how many medicinal agents are included at a tip portion of a manufactured microneedle, and what is a content of the agents corresponding to the protruding length of the microneedle tip.

Description

[0001] The present invention relates to a microneedle tip cutter for drug analysis,

The present invention relates to a micro-needle tip cutting apparatus for drug analysis, and more particularly, to a micro-needle tip cutting apparatus for drug analysis, And a microneedle tip cutting apparatus capable of precisely cutting the micro needle tip according to the protrusion length in order to confirm whether or not the micro needle tip has been cut.

Generally, the method of delivering drugs to human body can be roughly divided into oral administration method and parenteral injection method using needles. Although the oral administration method is easy to administer, side effects may occur in the gastrointestinal tract, and there is a first-pass effect in the liver, and it is not applicable to a drug in which intestinal absorption is not smooth. In addition, the above parenteral injection method is typically an injectable drug type, which is very effective in drug delivery but causes fear and pain to the patient and is difficult to maintain continuously.

As an alternative to this, a transdermal drug delivery system using microneedles in which a plurality of tip tips with a diameter of less than 1 mm are formed is proposed.

The microneedle formulation has the advantage of an injectable formulation that allows immediate and rapid systemic drug injection while avoiding hepatic first pass effects and gastrointestinal side effects. In addition, the micro needle formulation maintains constant blood drug concentration, facilitates drug injection and withdrawal, has high patient compliance, and enables non-invasive drug delivery, It is widely used in research field.

These microneedles are in the form of micro-sized needle-shaped tips which allow the drug to easily penetrate the stratum corneum of the skin by reversibly creating micro-perforations in the skin in terms of morphology, The formed tip may be formed into one or a plurality of drug delivery channels. Here, the tip of the microneedle has a length sufficient to pass through the stratum corneum, but it is short and sharp like not to cause pain. The tips of the microneedles can have a variety of geometric shapes and can be made of a variety of materials including silicon, metal, glass, and polymers.

In addition, the micro needle can be divided into the following four types according to the shape and administration method as follows.

1) Solid microneedles used for pretreatment of skin to improve drug permeability. 2) coated microneedles coated with drug dissolved in the skin on the surface of the needle. 3) dissolving microneedles in which drug is released from the skin as the needle is contained in the needle. 4) hollow microneedles that allow injection of drug solution.

Of these, soluble micro needles have received much attention over the past few years because they have many advantages over other types of micro needles in terms of drug loading, safety, and mass production potential. Particularly, as a method for improving the efficiency of drug administration, researches on micro needles in which drugs are loaded only at the tips of the tips are actively conducted.

In order to develop and directly apply the drug to the patient by the soluble micro needle preparation, it is necessary to know the exact content of the drug component (ex. API) contained in the micro needle. However, in order to analyze the content of the drug in the micro needle, it is necessary to cut and separate the tip from the pad surface to a desired height, and then analyze it. However, since a device for precisely separating the tip from the pad is not provided, The tip of the micro needle is separated and analyzed. In this way, it is difficult to remove the tip of the micro needle with manual operation, since the precision is poor, the reliability of inspection according to the content analysis is somewhat lowered, and cutting at the desired height is hardly achieved. Therefore, the development of the technology for the micro needle has been carried out in order to make the micro needle production process more precise than the content analysis from the manufactured micro needle.

Korean Registered Patent No. 10-1152486 (registered May 25, 2012, hereinafter referred to as 'Prior Art Document 1') proposes a method of manufacturing a micro needle pad and a manufacturing apparatus therefor. In the prior art document 1, a pad material having a predetermined thickness is coated by applying a pad material containing a phamaceutical component to a mold fabric, and a through hole is formed in a bottom surface of a mold fabric forming a tip portion of the micro needle, And the micro needle tip is formed in a designed shape by discharging the air in the groove of the mold fabric by vacuum suction.

Korean Registered Patent No. 10-1692266 (registered on Dec. 28, 2016, hereinafter referred to as 'Prior Art Document 2') has proposed a micro needle patch and its manufacturing method. In the prior art document 2, a medicinal ingredient is concentrated on the tip of the tip of the microneedle, and a pore is formed in the tip portion between the pad surface and the tip end portion so that the amount of the percutaneous feed can be adjusted.

Thus, the prior arts 1 and 2 merely show the way of controlling the amount and shape of the drug ingredient contained in the micro needle tip through the manufacturing method, and the degree of the drug content of the micro needle tip after the manufacture has not been verified.

This may cause side effects or deterioration of the therapeutic effect caused by excessive or inadequate content of the medicinal ingredient and may cause more serious damage in the case of patients who need continuous medicinal ingredient input.

Therefore, it is necessary to develop a device capable of more precisely separating the microneedle tip so as to judge whether or not the microneedle tip contains a certain amount of the pharmaceutical ingredient.

Korean Registered Patent No. 10-1152486 (registered May 25, 2012): Method for manufacturing micro needle pad and manufacturing apparatus therefor Korean Registered Patent No. 10-1692266 (registered on Dec. 28, 2016): Micro needle patches and manufacturing method thereof

According to an aspect of the present invention, there is provided a micro needle tip cutting apparatus,

A micro needle tip protruding from a pad surface of a micro needle can be cut at a desired height to provide a device that enables accurate content analysis and comparison between sample contents from a cut sample by collecting samples under the same conditions for various micro needles .

A microneedle tip cutting apparatus of the present invention for solving the above-

A microneedle tip cutting apparatus for cutting a tip from a microneedle having a plurality of tip ends protruding from a pad, the apparatus comprising: a plate fixed to a main body case, the plate having an inlet hole formed at a front side thereof, A blade supporting base formed on both sides of the inflow hole to form a clearance to allow a blade to be inserted therethrough and to remove vertical vibration by pressing a blade inserted into the clearance; A front and rear moving plate connected to the rail of the fixing plate and having front and rear moving means for moving the front and rear direction along the rail; A power converting unit that receives the power of the motor and converts the rotational motion into reciprocating linear motion and transmits the rotational motion to the reciprocating linear motion; a blade inserted into and moved to the blade support of the fixing plate; A blade support which is integrally coupled to the power conversion part and is connected to the power conversion part so as to move the blade in the left and right direction and a right and left guide bar which covers the extension part of the blade support to move left and right, Operating means; A sample placing table disposed on a lower portion of the fixing plate, the sample placing table being mounted on a front upper surface to seat the micro needles and elevating the micro needles through an inlet hole of the fixing hole, And a lifting plate having a base plate and a base plate.

The rail of the fixing plate is a plurality of gear teeth formed on the upper surface of the fixing plate in the front-rear direction; Wherein the means for moving the front and rear moving plates includes a moving gear engaged with the rail and rotatably mounted on the front and rear moving plates, and a moving motor provided on the front and rear moving plates for transmitting power to the moving gear, The front and rear moving plates can be moved forward and backward by operation.

The power converting unit of the blade operating unit may include: a driving gear that receives the power of the motor; An output gear rotatably engaged with the driving gear and having a connecting portion deflected at one side thereof; And a power transmission bar rotatably coupled to the connection portion of the output gear at one end thereof and rotatably coupled to the extended portion of the blade support at the other end thereof for transmitting rotational motion in a linear motion.

In addition, the blade support may be provided with a rotation preventing bar extending in the left and right direction at an intermediate portion of the extending portion; The left and right guide bars may be provided to be in contact with the front surface and the rear surface of the anti-rotation bar, respectively, so as to prevent the blade support from being rotated in the left-right direction.

Further, the elevating means of the elevating plate may be provided with a fine screw on the bottom of the elevating plate, so that the elevating means can be elevated by the rotation of the fine screw.

Wherein the fine adjustment screw is driven by an automatic adjustment device, the automatic adjustment device comprising: a control unit; a drive motor for transmitting and rotating power to the fine screw by a signal from the control unit; And a gap measuring sensor for measuring the gap between the fixing plate and the lift plate and transmitting the measured value to the control unit .

In addition, a digital vernier caliper for measuring the interval between the fixing plate and the lifting plate and displaying the interval in numerical value may further be mounted.

The sample seating table has a hollow portion formed therein and a plurality of micropores communicating with the hollow portion are formed on the upper surface. The hollow portion is communicated with the vacuum pump and the vacuum suction pipe, and the microneedles placed on the sample- .

The fixing plate may further include a cover for covering the upper portion of the blade holder to block the tip of the microneedle cut by the blade to prevent the blade from being discharged to the outside.

Further, the cover may be connected to a vacuum suction pipe connected to a vacuum pump at the upper portion thereof to suck and collect the cut microneedle tip.

The cover may be formed of a transparent material, and a microscope, a camera, and a convex lens may be further provided on the cover to confirm cutting or cutting state of the micro needle tip by the blade.

The micro-needle tip cutting apparatus of the present invention by the above-

In the reciprocating operation of the blade, the vibration generated in the vertical direction is removed, and the cutting is performed by accurate horizontal movement, thereby improving the cutting accuracy.

Further, since the tip portion of the micro needle can be cut along the height by finely adjusting the lifting and lowering by the lifting plate, the amount of the drug component according to the length of the micro needle tip can be accurately measured, By predicting the dose of the component, it is possible to prevent damage due to excessive use of the drug.

In addition, it has become possible to provide a useful device that improves the convenience, such as allowing the micro needle to be seated on the sample seating table and recovering the cut tip easily by vacuum suction.

1 is an exploded perspective view schematically showing a micro needle tip cutting apparatus according to an embodiment of the present invention;
FIGS. 2A and 2B are a plan view and a front view showing a power conversion unit according to an embodiment of the present invention;
3 is a plan view showing another form of the blade support of the blade operating means according to the present invention;
4 is a schematic sectional view showing an example of a steel plate elevating and lowering means according to the present invention.
5 is a block diagram showing another example of the lifting and lowering means according to the present invention.
6 is a schematic sectional view showing a sample seating table having a suction function according to an embodiment of the present invention;
7 is a schematic view showing an embodiment in which a lid is further provided on the fixing plate according to the present invention.
FIG. 8 is a schematic view showing an embodiment of a cover to which a vacuum suction pipe according to the present invention is connected. FIG.
FIG. 9A is a schematic view showing an embodiment in which a microscope is further provided on an upper part of a cover provided on a fixing plate of the present invention; FIG.
9B and 9C are schematic cross-sectional views showing an embodiment in which a convex lens or a camera is installed in the cover of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. BRIEF DESCRIPTION OF THE DRAWINGS The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which exemplary embodiments of the invention are shown. It is to be understood, however, that the invention is not intended to be limited to the particular forms disclosed, but on the contrary, is intended to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are shown enlarged or reduced from the actual size for the sake of clarity of the present invention.

The terminology used in this application is used only to describe a specific embodiment and is not intended to limit the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present application, the terms "comprises", "having", or "having" are used to specify that there is a feature, a number, a step, an operation, an element or a combination thereof disclosed in the specification, It should be understood that the foregoing does not preclude the presence or addition of other features, numbers, steps, operations, elements, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as commonly used and predefined terms should be construed to have meanings consistent with their contextual meanings in the relevant art and are not to be construed as ideal or overly formal in meaning unless expressly defined in the present application .

1 is an exploded perspective view schematically showing a micro needle tip cutting apparatus according to an embodiment of the present invention.

The micro needle tip cutting apparatus 10 according to the present invention includes a main body case (not shown), a fixing plate 20, a back and forth moving plate 30, a blade operating means 40, And a lifting plate (50).

The main body case may be provided in a tabletop shape or in a portable manner. The main body case may be fixed or supported in such a manner that it can be moved forward or backward or up and down, and various members necessary for driving can be mounted. In addition, the front surface can be provided with a structure in which the micro needles can be seated on the steel plate, or can be opened and closed to detachably attach the cover.

Next, the fixing plate 20 is a plate body fixedly mounted on the main body case, and an inlet hole 21 communicating with the upper portion of the microneedle disposed at the lower portion is formed at the front.

A blade support 44 is provided on both sides of the inflow hole 21 so that the blade is moved in the front, rear, and left and right directions from the inside of the two blade supports. The blade support 44 projects vertically from both sides of the inlet hole 21 of the fixing plate and then horizontally extends in the inward direction so as to be opposed to each other so that the inner blade 43 is spaced apart from the horizontal extending portion of the blade support and the upper surface of the fixing plate Allow horizontal movement in the gap. At this time, the height of the gap is equal to the thickness of the blade so that the horizontal extending portion of the blade support 44 and the fixing plate 20 support the blade 43 in the up and down direction, It is possible to suppress the upward and downward vibration that may occur in the forward and backward movement and to move the blade 43 to the same horizontal position so that cutting can be performed. In addition, when the blade support 44 is made of a material having elasticity, the height of the clearance gap is made smaller than the thickness of the blade to provide a strong gripping force in the up and down direction when the blade is moved.

A rail 23 is installed on the rear upper surface of the fixing plate 20 so that the front and rear moving plates 30 are moved in the forward and backward directions along the rail 23, 23 may be formed at the center thereof or on two sides thereof in parallel. The rail 23 has a simple structure in which a gear tooth or a groove is formed in the forward and backward direction on one side of the upper surface of the fixed plate so that the rail 23 can be engaged with the gear so that the rail 23 can move. So that it is possible to make a linear movement in the forward and backward directions. Here, the fixing plate includes a blade 43 and a fixed plate blade support 44, which are mounted on the front and rear moving plates positioned on the upper portion, Are arranged on the same horizontal line.

The back and forth moving plate 30 is a plate disposed on the top of the holding plate 20 and has a back and forth moving means 31 connected to the rail 23 of the holding plate and moving in the back and forth direction along the rail.

For example, a moving gear 311 engaged with the rail 23 when the gear 23 or the groove is formed, a moving motor 312 for transmitting power to the moving gear to operate the moving gear, . The moving motor 312 is installed on the front and rear moving plates and has a rotary shaft on one side or both sides and a moving gear 311 is mounted on the end of the rotating shaft so that the moving gear 311 is engaged with the rail 23 of the fixing plate A button for forward rotation or reverse rotation of the moving motor may be provided outside the main body case so that the blade of the back and forth moving plate is moved to cut the fixed micro needle tip.

When the LM guide actuator is used as the rail and the back and forth moving means, the rails and the ball screw are coupled to the fixed plate 20, the moving block coupled to the ball screw is coupled to the bottom surface of the back and forth moving plate 30, So that the moving block can be moved in the forward and backward direction along the rail by rotating the screw. Therefore, the rail includes a ball screw and a motor, and the back and forth moving plate may include a moving block. At this time, the motor of the LM guide actuator can also be operated by installing operation buttons on the outside of the main body case.

The blade operating means 40 is installed on the front and rear moving plate 30 to reciprocate the blade 43 in the left and right direction to cut the microneedle tip. The blade operating means 40 includes a motor 41 installed at an upper portion of the front and rear moving plate 30, a power converting portion (not shown) which receives the power of the motor and converts the rotational motion into reciprocating linear motion, A blade 43 inserted and moved into the blade support 44 of the fixing plate 20 and an extension 441 integrally coupled to the blade 43 and formed at the rear, And a left and right guide bar 45 for covering the extended portion 441 of the blade support and movable up and down with a constant width so as to remove vertical vibration, .

The motor 41 and the power converting unit 42 may further include a transmission. In addition, the blade 43 is in the form of a plate, and a blade is formed at a lower portion in contact with the fixing plate 20 so that the upper surface of the fixing plate is a cutting surface. The blade support 44 is integrally coupled with the rear portion of the blade 43. The blade support 44 has an extended portion 441 extending rearward at a rear end thereof, And is connected to the power converting unit 42 to receive the converted power from the power converting unit to reciprocate the blade in the left and right directions. The left and right guide bars 45 are installed to press the upper part of the extended part. The left and right guide bars 45 have the inverted U shape in which the lower part is opened. The extended part 441 of the blade support has a constant width, Is fixed to the front and rear moving plates. Therefore, the left and right guide bars 45 allow the extension 441 to move left and right but can restrict the upward and downward movement, so that vertical vibration can be removed.

In addition, the power converting unit 42 can convert the rotational motion of the motor into linear motion in the left and right directions by various methods. For example, referring to FIGS. 2A and 2B, the power converting unit 42 includes a driving gear 46 that receives the power of the motor 41; An output gear 47 which is engaged with the driving gear and is rotated at one side and the connecting portion 471 is deflected; The power transmission bar 48 is rotatably coupled to the connection portion 471 of the output gear at one end thereof and rotatably coupled to the extension portion 441 of the blade support at the other end thereof, ). ≪ / RTI > Here, a further gear group may be additionally provided between the driving gear 46 and the output gear 47 so that deceleration can be performed. Also, the driving gear and the output gear may be formed of bevel gears so that gear engagement can be performed at a right angle. In addition, the vibration in the vertical direction, which may be generated in the operation of the power transmitting bar for converting the rotational motion into the rectilinear motion, is removed by the pressing of the right and left guide bars or the restriction of the vertical movement.

Next, the lifting plate 50 is disposed on the lower portion of the fixing plate 20, and a sample seating table 51 on which the microneedles are mounted is protruded upward from the front upper surface. The elevating means 52 is provided on the elevating plate 50 and the elevating means lifts the elevating plate so that the sample placing table 51 disposed below the elevating plate inflowing hole is moved through the inflow hole 21 It is possible to cause the micro needles placed on the sample seating table 51 to be exposed to the upper side of the fixing plate, or to move up and down precisely.

Accordingly, the lifting plate 50 can be vertically slidably mounted in the main body case, or can be vertically elevated by applying various devices that lift and lower the lifting plate 50 while maintaining a horizontal plane by a separate means.

The cutting apparatus 10 configured as described above is constructed so that the micro needle is placed on the sample seating table 51 of the lift plate 50 and then the lift plate 50 is lifted by the lift means 52, And the front and rear moving plate 30 is moved forward by moving the blade 43 to reciprocate right and left by the blade operating means 40 so as to move the forward and backward moving plate 30 forward The tip portion of the micro needle can be cut horizontally.

3 is a plan view showing another embodiment of the blade support of the blade operating means according to the present invention.

As described above, the extended portion 441 of the blade support 44 is further provided with a rotation preventing bar 442 having an intermediate portion extended in the left and right direction. The left and right guide bars 45 are provided in two, And the blade support base 44 can be prevented from rotating in the left-right direction.

That is, if only one right and left guide bar 45 is attached to the extended portion 441 of the blade support 44 to press the blade, the vertical vibration can be removed. However, the blade support 44 and the power transmission bar 48 And the load is concentrated on the blade support and the power transmission coupling portion due to the warping, thereby causing a problem that the blade support is damaged.

Therefore, by providing the extension 441 with the anti-rotation bar 442 and mounting the left and right guide bars 45 in plural, it is possible to prevent the blade support 44 from rotating or bending to the left or right during the reciprocating movement in the left and right direction, And it is possible to stably suppress the occurrence of up-and-down vibration due to the occurrence of pressing by the plurality of right and left guide bars 45.

4 is a schematic cross-sectional view showing an example of the lifting and lowering means according to the present invention.

As shown in the figure, the elevating means 52 may be provided with fine meshing screws 521 applied to the microscope, so that the elevating means 52 can be accurately elevated and lowered. That is, the fine movement block 523, which is rotated by the rotation, is mounted on the fine thread, and the fine movement block is mounted on the lift plate 522, And is mounted on a slit 524 formed in the direction of the fine screw of the bottom surface. When the fine thread 521 is rotated in this configuration, the fine moving block 523 is moved to one side by the threads of the fine thread, guided by the slit 524 on the bottom of the steel plate, moved to one side, The lifting plate 50 is lifted or lowered by the inclination of the screw. Therefore, the lift plate 50 can be raised and lowered finely by the rotation of the fine screw 521, so that the tip of the microneedle can be cut to a desired length.

Further, the upper end of the fine support base 522 is fixed to the fixing plate 20 so that the lifting and lowering of the lifting plate can be performed inside thereof.

5 is a block diagram showing another example of the lifting and lowering means according to the present invention.

Referring to the drawings, the fine threaded screw 521 according to the present invention can be driven by the automatic adjustment device 53. [

The automatic regulating device 53 includes: a control unit 531 for controlling various signal transmission and power interrupting; A drive motor 532 for transmitting and rotating power to the fine screw by a signal from the control unit; A sensor (533) installed at one side of the inflow hole of the fixing plate, measuring a time when the protrusion protrudes through the inflow hole to the upper side of the fixing plate, and transmitting the measured value to the controller; And an interval measuring sensor 534 measuring the interval between the fixing plate and the lift plate and transmitting the measured value to the control unit.

The control unit 531 controls the driving motor 532 to rotate the fine screw 521 to raise the lifting plate 50. The sensing unit 533 senses the horizontal plane of the fixing plate inlet hole, The stopping position can be set as a reference point while the operation of the driving motor 532 is stopped. At this time, the detection sensors 533 may be formed as a plurality of detection points, and the tip portions of the micro needles may be set as reference points or the pad portions of the micro needles may be set as reference points. When the reference point is set, a desired height can be inputted to the control unit 531 through the external input device, and the control unit 531 operates the drive motor by the input value to move the steel plate. The moving distance is measured by an interval measuring sensor 534 which measures the distance between the fixed plate 20 and the lifting plate 50. When the distance value moved by the interval measuring sensor becomes equal to the input value, It is possible to stop the operation of the motor and move the lifting plate by a desired length.

In addition, a drive motor is connected to the fine adjustment screw and the button is installed outside the main body case, and the drive motor is operated by clicking the button, so that the fine adjustment screw can be automatically rotated.

In addition, the automatic adjustment device may be provided with a drive motor connected to the fine screw, and further provided with an interval measuring sensor for measuring the distance between the fixed plate and the lifting plate, so that the degree of movement of the lifting plate can be automatically adjusted. That is, the interval measured by the interval measuring sensor is transmitted to the control unit to be set as a reference value, and a desired height is set through the external input device. When the control unit inputs the interval to the control unit, the control unit operates the driving motor, So that the structure can be simplified.

Also, although not shown, a distance between the fixing plate and the rising steel plate can be expressed by a numerical value by mounting a digital vernier caliper.

Therefore, since the lifting and lowering of the lifting plate can be precisely controlled, the micro needle can be cut by the protruding length of the tip protruding from the patch portion, so that the human body dosage can be predicted by measuring the component content according to the protruding length, The design of the micro needle can be changed so that the micro needle can be administered in a quantitative manner.

6 is a schematic sectional view showing a sample seating table having a suction function according to an embodiment of the present invention.

As shown in the drawing, the sample seating table 51 mounted on the lifting plate 50 according to the present invention includes a hollow portion 511 formed therein and a plurality of micropores 512 communicating with the hollow portion on the upper surface thereof. And the hollow portion may be connected to the vacuum pump 60 through the vacuum suction pipe 513 to form a negative pressure.

When the negative pressure is formed on the hollow portion 511 of the sample seating table 51, the micro needle 70 that is seated on the sample seating table can be adsorbed through the micro pores of the sample seating table, It can be arranged horizontally and horizontally. Further, since the suction force through the micro pores 512 prevents the pads 71 of the micro needle 70 from lifting due to the pushing force of the blade forward in the cutting process, it is possible to cut the micro needle tip horizontally to obtain a precise sample .

The communicating position of the sample seating table 51 and the vacuum suction pipe 513 may be connected through the side surface of the sample seating table or may be connected through a lower steel plate to generate a negative pressure. Further, the vacuum pump 60 may be installed on the lifting plate to provide a suction force, or may be provided at one side of the body case, which is a space separate from the lifting plate, to provide a suction force. At this time, the vacuum pump can prevent the vibration generated during operation of the vacuum pump from being transmitted to other members by using an auxiliary member such as a dust-proof pad. In addition, only the vacuum suction pipe is piped inside the case body, It is possible to block the vibration and to provide only the vacuum suction force by connecting the vacuum pump provided outside.

7 is a schematic view showing an embodiment in which a lid is further provided on the fixing plate according to the present invention.

As shown in the drawing, the fixing plate 20 according to the present invention is further provided with a cover 24 covering the upper portion thereof to enclose the blade support 44.

The cover 24 further extends downward through the inflow hole 21 of the fixing plate to contact the front side wall of the elevated steel plate sample seating table 51 to close the inside space of the cover 24, As shown in FIG. Of course, it is preferable that both side walls of the sample seating table are brought into contact with or close to the inner wall of the inflow hole. Further, the rear side of the cover may also protrude downward by a predetermined length to narrow the rear open portion into which the blade flows.

Since the lid 24 is configured as described above, it is possible to prevent the tip from scattering and being discharged to the outside during the cutting process of the tip 72 of the micro needle 70, so that the tip can be easily recovered after the cutting process It can be provided in a detachable structure.

8 is a schematic view showing an embodiment of a lid to which a vacuum suction pipe according to the present invention is connected.

The cover 24 may be provided with a vacuum suction pipe 241 connected to the vacuum pump 60 at the upper portion thereof so that the tip that has been cut and separated from the microneedles in the cutting process can be recovered.

The vacuum suction pipe 241 mounted on the lid 24 is connected to a single vacuum pump to provide a suction force or to a vacuum pump for providing a suction force to a sample seating table of a lift plate to provide a suction force.

At this time, an intermittent valve may be provided on the line of the vacuum suction pipe 241 to make the vacuum suction force provided to the lid and the sample seating table different. For example, if the suction force provided by the lid 24 is higher than the suction force of the sample seating table 51, micro-needles fixed to the sample seating table may be lifted, so that the suction force provided by the lid is absorbed .

Also, when the cutting process is completed, a large suction force is temporarily generated, so that the cut tip located inside the lid can be sucked and collected at a time.

In addition, the lid 24 is connected to the front side of the vacuum suction pipe 241 to generate a suction force to the front side, whereby the tip is moved forward at the time of cutting and the shape is damaged by the operation of the reciprocating blade In addition, when the cutting is completed, a high suction force can be generated and the collection can be performed.

A collection chamber including a cyclone or a loop chamber may be provided on the line of the vacuum suction pipe 241 to collect the cutting tip moved by a temporary pressure drop or pressure difference. have.

9A is a schematic view showing an embodiment in which a microscope is further provided on the cover provided on the fixing plate of the present invention.

As shown in the figure, the lid 24 is made of a transparent material so that it can be observed from the outside, and a microscope 80 is further provided on the lid to check the cutting state of the micro needle tip by the blade in real time have.

The microscope 80 may be provided on the upper part of the lid 24 so as to allow the tip of the micro needle to be seen from the upper side or to be provided on the front side of the lid to allow the side of the micro needle to be seen from the side have. That is, it is possible to confirm whether or not the cut surface is horizontal when only a part of the tips protruding from the pad of the micro needle is cut.

The microscope 80 is mounted on a rotating bar 81 that is rotated by a hinge point at one point of the main body case, Is provided in the upper part or in the front part, so that it is possible to confirm the cutting face of the micro needle.

9B and 9C are schematic sectional views showing an embodiment in which a convex lens or a camera is installed on the lid of the present invention.

As shown in the figure, the convex lens 242 may be formed on the upper surface or the upper surface and the front side wall of the lid 24, respectively, so that the tip of the microneedle is cut or the cut state can be confirmed. At this time, the convex lens 242 is formed as a separate object, the lid 24 is provided with a through hole in a portion to which the convex lens is to be mounted, and the slit is attached to the outer surface of the through hole to easily attach / detach the convex lens 242 .

In addition, a camera 243 may be provided on the lid 24 so that the cut surface of the micro needle can be stored as an image. The camera 243 is detachably coupled to the through hole formed in the upper surface of the lid 24 and is connected to an external computer or a control device by an electric wire to transmit a photographed image or image file to an external device have.

In this case, the camera 243 installed on the cover may be configured to include a power unit, a wireless communication unit, a control unit, and the like. The camera mounted on the cover may use various known types of cameras capable of taking images of a minute object.

10: Cutting device
20: Fixing plate
21: inflow hole 22: blade support
23: rail 24: cover
241: vacuum suction pipe 242: convex lens
243: Camera
30: Moving back and forth
31:
311: Moving gear 312: Moving motor
40: blade operating means
41: motor 42: power converting section
43: blade 44: blade support
45: right and left guide bars 46: drive gear
47: Output gear 48: Power transmission bar
441: Extension portion 442:
471: Connection
50: Wrought steel plate
51: sample seating table 52: elevating means
53: Automatic regulator
511: Hollow section 512: Micropores
513: vacuum suction pipe
521: fine thread 522: fine support
523: fine movement block 524: slit
531: control unit 532: drive motor
533: detection sensor 534: interval measurement sensor
60: Vacuum pump
70: Micro needle
71: Pad 72: Tip
80: Microscope
81: Rotating bar

Claims (11)

A micro needle tip cutting apparatus for cutting a tip from a microneedle protruding from a pad with a plurality of tip ends,
An inlet hole (21) formed at the front side to protrude the upper portion of the microneedle, which is a sample, which is raised and lowered, and a gap formed between the inlet hole and the inflow hole, A blade support base 44 for pressing the upper and lower vibrations to remove the upper and lower vibrations, and a rail 23 installed in the front and rear direction on the rear upper surface;
A front and rear moving plate (30) having a plate disposed on the upper side of the fixing plate (20) and having a front and rear moving means (31) connected to the rail of the fixing plate and moving in the front and rear direction along the rail;
A power converting unit 42 that receives the power of the motor and converts the rotational motion into a reciprocating linear motion and transmits the linear motion to the reciprocating linear motion; A blade support 44 integrally coupled to the blade and connected to the power conversion unit by an extension formed at the rear to move the blade leftward and rightward, an extension 441 of the blade support, A left and right guide bar 45 for pressing the upper and lower portions of the guide bar 45 so as to move left and right to remove vertical vibration;
A sample placing table 51 which is mounted on a lower portion of the fixing plate 20 and on which a microneedle mounted on the front upper surface is seated and lifted up through an inlet hole of the fixing hole and a fixing plate And a lifting plate (50) provided with lifting means (52) for narrowing or spacing the lifting means (52). The method according to claim 1,
The rail 23 of the fixing plate 20 is a plurality of gear teeth formed on the upper surface of the fixing plate in the forward and backward directions,
The back and forth moving means 31 of the front and rear moving plate 30 includes a moving gear 311 engaged with the rail and rotatably mounted on the front and rear moving plates, And a moving motor (312) for moving the front and rear moving plates forward and backward by an external button operation. The method according to claim 1,
The power converting portion (42) of the blade operating means (40)
A drive gear 46 for receiving the power of the motor 41;
An output gear 47 which is engaged with the driving gear and rotates, and a connection part 471 is deflected at one side;
A power transmission bar 48 rotatably coupled to the connection portion 471 of the output gear at one end thereof and rotatably coupled to the extended portion 441 of the blade support to transmit rotational motion in a linear motion; Wherein the tip of the micro-needle tip is positioned at the tip of the micro-needle tip. The method according to claim 1,
The blade support base (44) is formed with a rotation preventing base (442) extending in the left and right direction at an intermediate portion of the extended portion,
The left and right guide bars 45 are installed in two positions so as to be in contact with the front surface and the rear surface of the anti-rotation bar 442, respectively, thereby preventing the blade support table 44 from rotating in the left- Cutting device. The method according to claim 1,
Wherein the elevating means (52) of the elevating plate (50) is provided with a fine thread (521) on the bottom of the elevating plate and is lifted and lowered by rotation of the fine screw. 6. The method of claim 5,
The fine thread 521 is driven by the automatic adjustment device 53,
The automatic control device 53 includes a control unit 531, a drive motor 532 that transmits and rotates the power to the fine thread 521 by a signal from the control unit, A sensing sensor 533 for measuring the time when the protruding portion is projected to the upper portion of the fixing plate through the fixing plate 533 and transmitting the measured value to the control unit, and an interval measuring sensor 534 for measuring the interval between the fixing plate and the lift plate and transmitting the measured value to the control unit Wherein the micro-needle tip cutting device comprises: 6. The method of claim 5,
Further comprising a digital vernier caliper for measuring an interval between the fixing plate and the lifting plate and displaying the interval in terms of a numerical value. The method according to claim 1,
The sample seating table 51 has a hollow portion 511 formed therein and a top surface thereof formed with a plurality of micropores 512 communicating with the hollow portion. The hollow portion includes a vacuum pump 60 and a vacuum suction pipe 513, And the microneedles (70), which are communicated with the sample holding table (51) and placed on the sample seating table (51), are adhered with negative pressure. The method according to claim 1,
And a lid (24) for covering the upper part of the fixing plate (20) so as to enclose the blade support (44) and preventing the microneedle tip cut by the blade from being scattered and being prevented from being discharged to the outside is further provided. Cutting device. 10. The method of claim 9,
Wherein the lid (24) is further connected to a vacuum suction pipe (241) connected to a vacuum pump (60) to suck and collect the cut microneedle tip. 10. The method of claim 9,
The cover 24 is made of a transparent material and one of a microscope 80, a camera 243, and a convex lens 242 for confirming cutting or cutting state of the micro needle tip by the blade is formed on the cover Wherein the micro-needle tip cutting device is provided with a micro-needle tip cutting device.

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