KR20190005184A - 강력한 항종양 활성을 갖는 tlr9-표적화된 구형 핵산 - Google Patents

강력한 항종양 활성을 갖는 tlr9-표적화된 구형 핵산 Download PDF

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KR20190005184A
KR20190005184A KR1020187034953A KR20187034953A KR20190005184A KR 20190005184 A KR20190005184 A KR 20190005184A KR 1020187034953 A KR1020187034953 A KR 1020187034953A KR 20187034953 A KR20187034953 A KR 20187034953A KR 20190005184 A KR20190005184 A KR 20190005184A
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sna
cancer
core
oligonucleotide
checkpoint inhibitor
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KR1020187034953A
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Korean (ko)
Inventor
수바라오 날라가틀라
바트 앤더슨
에캄바 칸디말라
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엑시큐어, 인크.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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KR1020187034953A 2016-05-06 2017-05-05 강력한 항종양 활성을 갖는 tlr9-표적화된 구형 핵산 Ceased KR20190005184A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662333139P 2016-05-06 2016-05-06
US62/333,139 2016-05-06
US201762480936P 2017-04-03 2017-04-03
US62/480,936 2017-04-03
PCT/US2017/031423 WO2017193084A1 (en) 2016-05-06 2017-05-05 Tlr9-targeted spherical nucleic acids having potent antitumor activity

Publications (1)

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KR20190005184A true KR20190005184A (ko) 2019-01-15

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KR1020187034953A Ceased KR20190005184A (ko) 2016-05-06 2017-05-05 강력한 항종양 활성을 갖는 tlr9-표적화된 구형 핵산

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Country Link
US (1) US20250304974A1 (enExample)
EP (1) EP3452600A4 (enExample)
JP (1) JP7062599B2 (enExample)
KR (1) KR20190005184A (enExample)
CN (2) CN109831915A (enExample)
AU (2) AU2017261357B2 (enExample)
CA (1) CA3023449A1 (enExample)
WO (1) WO2017193084A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2725948T3 (es) 2014-06-04 2019-09-30 Exicure Inc Suministro multivalente de inmunomoduladores mediante ácidos nucleicos esféricos liposomales para aplicaciones profilácticas o terapéuticas
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
WO2019217870A1 (en) * 2018-05-10 2019-11-14 Northwestern University Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology
EP3923957A4 (en) * 2019-02-12 2022-11-02 Exicure Operating Company COMBINED SPHERICAL NUCLEIC ACID AND CHECKPOINT INHIBITOR FOR ANTITUMORS THERAPY
KR102825937B1 (ko) * 2019-07-11 2025-06-27 주식회사 굳티셀 면역체크포인트 억제제 저항성 암의 예방, 개선 또는 치료용 조성물
EP4031142A1 (en) * 2019-09-19 2022-07-27 Danmarks Tekniske Universitet Immune stimulating micelle composition
US20230102924A1 (en) * 2020-03-10 2023-03-30 Emory University Methods of Treating Cancer Using Checkpoint Inhibitors in Combination with Purine Cleaving Enzymes
AU2021259571A1 (en) 2020-04-22 2022-10-27 Nutcracker Therapeutics, Inc. mRNA treatment nanoparticles
JPWO2022050369A1 (enExample) 2020-09-04 2022-03-10
TWI869643B (zh) * 2020-12-28 2025-01-11 財團法人工業技術研究院 免疫刺激性脂質複合體、包含免疫刺激性脂質複合體的醫藥組合物以及其用途
US20220370490A1 (en) * 2021-05-21 2022-11-24 Northwestern University Synergistic immunostimulation through the dual activation of tlr3/9 with spherical nucleic acids
CN117233391A (zh) * 2023-08-28 2023-12-15 南方医科大学南方医院 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1904530A2 (en) * 2005-07-07 2008-04-02 Coley Pharmaceutical Group, Inc. Anti-ctla-4 antibody and cpg-motif-containing synthetic oligodeoxynucleotide combination therapy for cancer treatment
WO2015013673A1 (en) * 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
ES2725948T3 (es) * 2014-06-04 2019-09-30 Exicure Inc Suministro multivalente de inmunomoduladores mediante ácidos nucleicos esféricos liposomales para aplicaciones profilácticas o terapéuticas
IL251669B2 (en) * 2014-10-10 2023-02-01 Idera Pharmaceuticals Inc Cancer treatment using a tlr9 agonist with checkpoint inhibitors

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Publication number Publication date
EP3452600A1 (en) 2019-03-13
CA3023449A1 (en) 2017-11-09
AU2024227671A1 (en) 2024-12-12
JP2019514985A (ja) 2019-06-06
AU2017261357A1 (en) 2018-11-29
EP3452600A4 (en) 2020-01-15
CN109831915A (zh) 2019-05-31
US20250304974A1 (en) 2025-10-02
CN116875609A (zh) 2023-10-13
JP7062599B2 (ja) 2022-05-06
AU2017261357B2 (en) 2024-08-01
WO2017193084A1 (en) 2017-11-09

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