JP7062599B2 - 強力な抗腫瘍活性を有するｔｌｒ９を標的化する球状核酸 - Google Patents

強力な抗腫瘍活性を有するｔｌｒ９を標的化する球状核酸 Download PDF

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JP7062599B2
JP7062599B2 JP2018558352A JP2018558352A JP7062599B2 JP 7062599 B2 JP7062599 B2 JP 7062599B2 JP 2018558352 A JP2018558352 A JP 2018558352A JP 2018558352 A JP2018558352 A JP 2018558352A JP 7062599 B2 JP7062599 B2 JP 7062599B2
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sna
pharmaceutical composition
cancer
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composition according
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JP2019514985A (ja
JP2019514985A5 (enExample
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ナラガトラ，スバラオ
アンダーソン，バート
カンディマラ，エカンバー
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Exicure Operating Co
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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JP2018558352A 2016-05-06 2017-05-05 強力な抗腫瘍活性を有するｔｌｒ９を標的化する球状核酸 Active JP7062599B2 (ja)

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Application Number Priority Date Filing Date Title
US201662333139P 2016-05-06 2016-05-06
US62/333,139 2016-05-06
US201762480936P 2017-04-03 2017-04-03
US62/480,936 2017-04-03
PCT/US2017/031423 WO2017193084A1 (en) 2016-05-06 2017-05-05 Tlr9-targeted spherical nucleic acids having potent antitumor activity

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JP2019514985A JP2019514985A (ja) 2019-06-06
JP2019514985A5 JP2019514985A5 (enExample) 2020-06-18
JP7062599B2 true JP7062599B2 (ja) 2022-05-06

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US (1) US20250304974A1 (enExample)
EP (1) EP3452600A4 (enExample)
JP (1) JP7062599B2 (enExample)
KR (1) KR20190005184A (enExample)
CN (2) CN116875609A (enExample)
AU (2) AU2017261357B2 (enExample)
CA (1) CA3023449A1 (enExample)
WO (1) WO2017193084A1 (enExample)

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US10434064B2 (en) 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
US11696954B2 (en) 2017-04-28 2023-07-11 Exicure Operating Company Synthesis of spherical nucleic acids using lipophilic moieties
US20210189397A1 (en) * 2018-05-10 2021-06-24 Northwestern University Self-manageable abnormal scar treatment with spherical nucleic acid (sna) technology
US20220088059A1 (en) * 2019-02-12 2022-03-24 Exicure Operating Company Combined spherical nucleic acid and checkpoint inhibitor for antitumor therapy
CN114173814A (zh) * 2019-07-11 2022-03-11 古德T细胞有限公司 用于预防、改善或治疗免疫检查点抑制剂耐药癌症的组合物
CN114514015B (zh) * 2019-09-19 2025-01-07 丹麦科技大学 免疫刺激胶束组合物
US20230102924A1 (en) * 2020-03-10 2023-03-30 Emory University Methods of Treating Cancer Using Checkpoint Inhibitors in Combination with Purine Cleaving Enzymes
EP4139044A4 (en) 2020-04-22 2025-01-01 Nutcracker Therapeutics, Inc. MRNA PROCESSING NANOPARTICLES
US20230321251A1 (en) 2020-09-04 2023-10-12 Osaka University Liposome formulation containing antibacterial agent
JP2022104889A (ja) * 2020-12-28 2022-07-12 財團法人工業技術研究院 免疫刺激性リポプレックス、免疫刺激性リポプレックスを含む医薬組成物、およびその用途
US20220370490A1 (en) * 2021-05-21 2022-11-24 Northwestern University Synergistic immunostimulation through the dual activation of tlr3/9 with spherical nucleic acids
CN117233391A (zh) * 2023-08-28 2023-12-15 南方医科大学南方医院 一种用于预测胃癌免疫治疗和/或化疗疗效的生物标志物及其应用

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WO2016057898A1 (en) 2014-10-10 2016-04-14 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonist with checkpoint inhibitors

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CN101268101A (zh) * 2005-07-07 2008-09-17 科利制药集团公司 用于癌症治疗的抗-CTLA-4抗体和含有CpG基序的合成寡脱氧核苷酸联合治疗
WO2015013673A1 (en) * 2013-07-25 2015-01-29 Aurasense Therapeutics, Llc Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
US10434064B2 (en) * 2014-06-04 2019-10-08 Exicure, Inc. Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications

Patent Citations (1)

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WO2016057898A1 (en) 2014-10-10 2016-04-14 Idera Pharmaceuticals, Inc. Treatment of cancer using tlr9 agonist with checkpoint inhibitors

Non-Patent Citations (3)

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Title
LIN, A.Y., et al.，PLOS ONE，2013年，Vol.8, No.5, e63550，pp.1-9.
MANGSBO, S.M., et al.，Journal of Immunotherapy，2010年，Vol.33, No.3，pp.225-235.
RADOVIC-MORENO, A.F., et al.，Proceedings of the National Academy of Science，2015年，Vol.112, No.13，pp.3892-3897.

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WO2017193084A1 (en) 2017-11-09
KR20190005184A (ko) 2019-01-15
CN109831915A (zh) 2019-05-31
EP3452600A4 (en) 2020-01-15
AU2017261357B2 (en) 2024-08-01
AU2024227671A1 (en) 2024-12-12
CN116875609A (zh) 2023-10-13
AU2017261357A1 (en) 2018-11-29
JP2019514985A (ja) 2019-06-06
US20250304974A1 (en) 2025-10-02
EP3452600A1 (en) 2019-03-13
CA3023449A1 (en) 2017-11-09

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