KR20180132807A - 신경퇴행성 질환의 치료용 tdp-43 미토콘드리아 국소화 억제제 - Google Patents
신경퇴행성 질환의 치료용 tdp-43 미토콘드리아 국소화 억제제 Download PDFInfo
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- 210000002845 virion Anatomy 0.000 description 1
- 230000031836 visual learning Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000001262 western blot Methods 0.000 description 1
- 238000011816 wild-type C57Bl6 mouse Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Neurosurgery (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rehabilitation Therapy (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662319580P | 2016-04-07 | 2016-04-07 | |
| US62/319,580 | 2016-04-07 | ||
| US201662328484P | 2016-04-27 | 2016-04-27 | |
| US62/328,484 | 2016-04-27 | ||
| PCT/US2017/026675 WO2017177178A1 (en) | 2016-04-07 | 2017-04-07 | Tdp-43 mitochondrial localization inhibitor for the treatment of neurodegenerative disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180132807A true KR20180132807A (ko) | 2018-12-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187031919A Ceased KR20180132807A (ko) | 2016-04-07 | 2017-04-07 | 신경퇴행성 질환의 치료용 tdp-43 미토콘드리아 국소화 억제제 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11124553B2 (OSRAM) |
| EP (1) | EP3440094B1 (OSRAM) |
| JP (1) | JP2019513752A (OSRAM) |
| KR (1) | KR20180132807A (OSRAM) |
| CN (1) | CN109563130A (OSRAM) |
| AU (1) | AU2017248353A1 (OSRAM) |
| CA (1) | CA3020344A1 (OSRAM) |
| SG (1) | SG11201808829VA (OSRAM) |
| WO (1) | WO2017177178A1 (OSRAM) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220040945A (ko) | 2020-09-24 | 2022-03-31 | 재단법인대구경북과학기술원 | Hdac6의 tdp-43 단백질병증 예방 또는 치료제로서의 용도 |
| WO2024181693A1 (ko) * | 2023-02-28 | 2024-09-06 | (주)케어젠 | 펩타이드 복합체를 유효성분으로 포함하는 항노화용 조성물 |
| KR20250016616A (ko) | 2023-07-20 | 2025-02-04 | 충북대학교 산학협력단 | cAbl에 의한 TDP43의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법 |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3645557B1 (en) | 2017-06-28 | 2024-10-23 | The Cleveland Clinic Foundation | Treatment of nervous system injury and neurodegenerative disorders and related conditions |
| CN113683703B (zh) * | 2020-05-18 | 2023-08-15 | 中国人民解放军陆军军医大学第二附属医院 | 一种hTERT靶向物及其用途 |
| WO2021247893A1 (en) * | 2020-06-03 | 2021-12-09 | Yumanity Therapeutics, Inc. | Bicyclic heteroaromatic amide compounds and uses thereof |
| CN114057858B (zh) * | 2020-08-10 | 2023-03-21 | 上海瑞吉康生物医药有限公司 | 对引起神经变性和神经退行性疾病的蛋白聚集具有解聚作用的多肽 |
| JP6961278B1 (ja) * | 2021-03-10 | 2021-11-05 | 国立研究開発法人量子科学技術研究開発機構 | 生体試料中のtdp−43を測定する方法及び装置 |
| CN113450336B (zh) * | 2021-07-01 | 2022-10-25 | 维柯基科技(上海)有限公司 | 一种多孔荧光微阵列图像的处理方法、装置、计算机设备及计算机可读存储介质 |
| WO2025152803A1 (zh) * | 2024-01-17 | 2025-07-24 | 四川大学 | 一种靶向traf6的多肽及其用途 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US5652122A (en) | 1989-12-21 | 1997-07-29 | Frankel; Alan | Nucleic acids encoding and methods of making tat-derived transport polypeptides |
| US5804604A (en) | 1989-12-21 | 1998-09-08 | Biogen, Inc. | Tat-derived transport polypeptides and fusion proteins |
| JP3150340B2 (ja) | 1990-11-13 | 2001-03-26 | イムネクス コーポレイション | 二機能選択可能融合遺伝子 |
| JPH09500783A (ja) | 1993-05-21 | 1997-01-28 | ターゲッティッド ジェネティクス コーポレイション | シトシンデアミナーゼ(cd)遺伝子に基づく二機能性選択融合遺伝子 |
| US5858683A (en) * | 1996-08-30 | 1999-01-12 | Matritech, Inc. | Methods and compositions for the detection of cervical cancer |
| GB9718609D0 (en) | 1997-09-02 | 1997-11-05 | Imp College Innovations Ltd | Fusion protein |
| GB9723824D0 (en) * | 1997-11-11 | 1998-01-07 | Actinova Ltd | Cytostatic agents |
| EP1305333A4 (en) | 2000-07-31 | 2006-04-12 | Active Motif | PEPTIDE-MEDIATED DELIVERY OF MOLECULES IN CELLS |
| US20040229837A1 (en) * | 2003-05-15 | 2004-11-18 | Yijuang Chern | Treatment of neurodegenerative diseases |
| WO2007005948A2 (en) * | 2005-07-01 | 2007-01-11 | Arbor Vita Corporation | Methods and compositions for diagnosis and treatment of viral and bacterial infections |
| CA2671410C (en) | 2006-12-06 | 2016-11-22 | Thomas Jefferson University | Peptide and treatment for hiv-1 infection |
| CA2713871C (en) | 2008-02-01 | 2018-05-22 | Washington University In St. Louis | Sequences associated with tdp-43 proteinopathies and methods of using the same |
| WO2010072228A1 (en) * | 2008-12-22 | 2010-07-01 | Xigen S.A. | Novel transporter constructs and transporter cargo conjugate molecules |
| WO2013012811A2 (en) * | 2011-07-19 | 2013-01-24 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
| US20150045248A1 (en) * | 2012-02-28 | 2015-02-12 | National University Corporation Tokyo University Of Agriculture And Technology | Method for identifying disease associated with abundance of tdp-43 in cell |
| US9017672B2 (en) * | 2012-05-11 | 2015-04-28 | Immunicum Aktiebolag | Hexon Tat-PTD modified adenovirus and uses thereof |
| WO2013192298A1 (en) * | 2012-06-22 | 2013-12-27 | The Scripps Research Institute | Apoptosis biomarkers |
| GB201408255D0 (en) * | 2014-05-09 | 2014-06-25 | Immatics Biotechnologies Gmbh | Novel immunotherapy against several tumours of the blood, such as acute myeloid leukemia (AML) |
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2017
- 2017-04-07 WO PCT/US2017/026675 patent/WO2017177178A1/en not_active Ceased
- 2017-04-07 AU AU2017248353A patent/AU2017248353A1/en not_active Abandoned
- 2017-04-07 CN CN201780028382.0A patent/CN109563130A/zh active Pending
- 2017-04-07 US US16/090,786 patent/US11124553B2/en active Active
- 2017-04-07 CA CA3020344A patent/CA3020344A1/en not_active Abandoned
- 2017-04-07 EP EP17779936.8A patent/EP3440094B1/en active Active
- 2017-04-07 JP JP2018552826A patent/JP2019513752A/ja active Pending
- 2017-04-07 KR KR1020187031919A patent/KR20180132807A/ko not_active Ceased
- 2017-04-07 SG SG11201808829VA patent/SG11201808829VA/en unknown
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2021
- 2021-09-21 US US17/480,884 patent/US12129285B2/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220040945A (ko) | 2020-09-24 | 2022-03-31 | 재단법인대구경북과학기술원 | Hdac6의 tdp-43 단백질병증 예방 또는 치료제로서의 용도 |
| WO2024181693A1 (ko) * | 2023-02-28 | 2024-09-06 | (주)케어젠 | 펩타이드 복합체를 유효성분으로 포함하는 항노화용 조성물 |
| KR20250016616A (ko) | 2023-07-20 | 2025-02-04 | 충북대학교 산학협력단 | cAbl에 의한 TDP43의 특이적 인산화 분석을 통한 신경퇴행성 질환을 진단하는 방법 및 이를 이용한 신경퇴행성 질환의 치료제 스크리닝 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3440094B1 (en) | 2021-02-17 |
| EP3440094A4 (en) | 2019-03-20 |
| US11124553B2 (en) | 2021-09-21 |
| EP3440094A1 (en) | 2019-02-13 |
| AU2017248353A1 (en) | 2018-10-25 |
| WO2017177178A1 (en) | 2017-10-12 |
| US20190211070A1 (en) | 2019-07-11 |
| US12129285B2 (en) | 2024-10-29 |
| CA3020344A1 (en) | 2017-10-12 |
| JP2019513752A (ja) | 2019-05-30 |
| CN109563130A (zh) | 2019-04-02 |
| SG11201808829VA (en) | 2018-11-29 |
| US20220220173A1 (en) | 2022-07-14 |
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