KR20180119597A - 염증 상태의 급성 악화의 치료를 위한 투약법 - Google Patents

염증 상태의 급성 악화의 치료를 위한 투약법 Download PDF

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Publication number
KR20180119597A
KR20180119597A KR1020187026085A KR20187026085A KR20180119597A KR 20180119597 A KR20180119597 A KR 20180119597A KR 1020187026085 A KR1020187026085 A KR 1020187026085A KR 20187026085 A KR20187026085 A KR 20187026085A KR 20180119597 A KR20180119597 A KR 20180119597A
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KR
South Korea
Prior art keywords
days
cyanobenzoyl
pyrazol
amino
dose
Prior art date
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Ceased
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KR1020187026085A
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English (en)
Korean (ko)
Inventor
콜린 오포드
시릴 클라크
콜름 패럴
재클린 파킨
스테판 드 벅
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메레오 바이오파마 1 리미티드
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Publication of KR20180119597A publication Critical patent/KR20180119597A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187026085A 2016-03-08 2016-03-08 염증 상태의 급성 악화의 치료를 위한 투약법 Ceased KR20180119597A (ko)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2016/050635 WO2017153701A1 (en) 2016-03-08 2016-03-08 Dosage regimen for the treatment of acute exacerbations of inflammatory conditions

Publications (1)

Publication Number Publication Date
KR20180119597A true KR20180119597A (ko) 2018-11-02

Family

ID=55646778

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187026085A Ceased KR20180119597A (ko) 2016-03-08 2016-03-08 염증 상태의 급성 악화의 치료를 위한 투약법

Country Status (9)

Country Link
US (1) US10617674B2 (https=)
JP (1) JP6741773B2 (https=)
KR (1) KR20180119597A (https=)
AU (1) AU2016397046B2 (https=)
BR (1) BR112018067784A2 (https=)
CA (1) CA3016368A1 (https=)
MX (1) MX389563B (https=)
RU (1) RU2709509C1 (https=)
WO (1) WO2017153701A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018067454A2 (pt) * 2016-03-08 2019-01-15 Mereo Biopharma 1 Ltd regime de dosagem para o tratamento de exacerbações agudas de doença pulmonar obstrutiva crônica
GB201612240D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide
GB201612238D0 (en) 2016-07-14 2016-08-31 Mereo Biopharma 1 Ltd Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide
AU2018382895B2 (en) * 2017-12-11 2024-05-16 Mereo Biopharma 1 Limited Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
US6598603B1 (en) 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
KR101120857B1 (ko) * 2003-06-26 2012-04-12 노파르티스 아게 5원의 헤테로사이클-기재 ｐ38 키나제 억제제
RU2381219C2 (ru) * 2003-06-26 2010-02-10 Новартис Аг ПРОИЗВОДНЫЕ 5-ЧЛЕННЫХ ГЕТЕРОЦИКЛОВ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ p38
TWI439284B (zh) 2004-04-09 2014-06-01 艾伯維生物技術有限責任公司 用於治療ＴＮＦα相關失調症之多重可變劑量療法
GB0409703D0 (en) 2004-04-30 2004-06-02 Vectura Ltd Pharmaceutical compositions
US20050277602A1 (en) * 2004-05-21 2005-12-15 Grunstein Michael M Methods employing agonists of P38 map kinase for the treatment of asthma
CA2640665A1 (en) * 2006-02-10 2007-08-16 Pfizer Products Inc. Pyridinone pyrazole urea and pyrimidinone pyrazole urea derivatives
GB0603684D0 (en) 2006-02-23 2006-04-05 Novartis Ag Organic compounds
RU2625762C2 (ru) 2012-03-20 2017-07-18 Новартис Аг Применение производной пиразола в лечении острых приступов хронической обструктивной болезни легких

Also Published As

Publication number Publication date
MX2018010781A (es) 2018-11-09
US10617674B2 (en) 2020-04-14
RU2709509C1 (ru) 2019-12-18
AU2016397046A1 (en) 2018-09-06
US20190091203A1 (en) 2019-03-28
WO2017153701A1 (en) 2017-09-14
JP6741773B2 (ja) 2020-08-19
MX389563B (es) 2025-03-20
CA3016368A1 (en) 2017-09-14
JP2019507785A (ja) 2019-03-22
AU2016397046B2 (en) 2022-05-12
BR112018067784A2 (pt) 2019-01-15

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Publication Publication Date Title
US11129810B2 (en) Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease
KR20180119597A (ko) 염증 상태의 급성 악화의 치료를 위한 투약법
TWI436761B (zh) 使用噻唑衍生物之方法
AU2018381874B2 (en) Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease
AU2018382895B2 (en) Use of 3-(5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl)-N-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease
HK40020426B (en) Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease
HK40020426A (en) Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease

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