KR20180069488A - Dissolvable film comprising spicule and use thereof - Google Patents

Abstract

The present invention relates to: a dissolvable film comprising spicule; a method for promoting skin absorption of a cosmetic composition using the same; and beauty sheets and patches comprising the dissolvable film. The hydrogel composition containing the spicule of the present invention has excellent skin regeneration effects by itself.

Description

DISSOLVABLE FILM COMPRISING SPICULE AND USE THEREOF FIELD OF THE INVENTION [0001]

The present invention relates to a soluble film containing a speckle, a method for promoting skin absorption of a cosmetic composition using the same, and a cosmetic patch comprising the soluble film.

Skin is the primary barrier of the human body. It protects the internal organs of the body from external stimuli such as changes in temperature and humidity, ultraviolet rays, and pollutants, and plays an important role in the maintenance of body homeostasis such as body temperature control. This important skin also becomes aged gradually as the age of the human body grows, and as a result, skin elasticity loss, keratinization, wrinkle formation, skin atrophy and the like appear. This aging of the skin not only causes wrinkles on the skin surface but also changes the entire line of the face.

Such aging of the skin can slow down a little by providing nourishment to the skin when the skin becomes rough or sunburned and tired, and by applying elasticity to the facial skin. In order to supply nutrients to damaged skin, it is necessary to apply natural ingredients such as Oatana citrus, massage cream, nutritional packs, cleansing packs, bleach packs, etc. and apply them on the face with beauty tissue or other auxiliary means It is generally used.

In recent years, in order to easily massage a face, a nonwoven fabric or a cosmetic film is compressed into a certain shape, and then various components having skin moisturizing, wrinkle improving, whitening effect, etc. are dissolved in a liquid form of an essence formulation, A variety of functional mask sheets made by wetting have been released.

However, these materials have limited use due to safety problems such as irritation, erythema, and redness when applied to the skin, or the effect is insignificant, so that the effect of skin function improvement or wound healing can not be expected substantially. Accordingly, there is a desperate need to develop a new composition which is safer and more effective in living body than existing skin external composition compositions.

Further, in relation to a technique of delivering an effective ingredient of a cosmetic composition to the skin, US Patent No. 5,322,683 discloses a method of making a water-free formulation so as not to contain water. However, It is troublesome and difficult to apply to water-soluble active ingredients in particular.

On the other hand, there are conventional techniques related to skin patch type include a hydrogel patch of European patent EP 0840597B1 and a hydrophilic film for skin care and wound healing of Korea Patent No. 10-0676937. However, There is a drawback that it is insufficient.

Therefore, it is required to develop a cosmetic composition and a patch which are effectively absorbed in the skin to thereby provide a skin effect improvement effect and a less irritation.

European Patent No. 0840597 Korea Patent No. 10-0676937

It is an object of the present invention to provide a soluble film composition comprising a speckle.

Another object of the present invention is to provide a method for promoting skin absorption of a cosmetic composition using the above-mentioned soluble film composition.

It is still another object of the present invention to provide a beauty sheet comprising the above-mentioned soluble film composition.

It is still another object of the present invention to provide a cosmetic patch for local skin care comprising the above-mentioned soluble film composition.

According to one aspect of the present invention, there is provided a soluble film composition comprising a speckle.

In the present invention, " speckle " is also called sponge, and sponge animal is a primitive marine creature with no muscles, nerves, or organs. More than 5,000 species are present, It is a living thing. The skeleton is a tissue that functions as a skeleton that has a needle shape present in the body of invertebrate animals, and is mainly composed of silicic acid and calcium carbonate. The fibrous skeleton of sponges has absorption ability according to the capillary phenomenon and is applied to various fields such as medical use. For example, the fragments of sponges contain antibiotics for treating osteomyelitis and are used for the treatment and prevention of diseases.

Specifically, the speckle may be contained in an amount of 0.001 to 20% by weight relative to the total film composition. There is an advantage of exhibiting excellent skin regeneration, wrinkle improvement or skin texture improving effect within the above-mentioned range, and there is an advantage that the formulation of the composition is stabilized.

In addition, the particle size of the speckle may be 40 탆 to 200 탆, more specifically 60 탆 to 100 탆, most specifically 70 탆 to 90 탆.

In Example 1 of the present invention, a soluble film containing a speucule having a size of 80 mu m was prepared (Example 1), and the soluble film prepared as described above was used for skin regeneration effect (Table 2) And when used in combination with other cosmetic compositions, it was confirmed that the active ingredients of other cosmetic compositions exhibited skin absorption promotion effects (Table 4).

In the present invention, a " soluble film " refers to a film that is less soluble in the skin when it is applied to or adhered to the skin when it is applied or adhered to the skin, and there is no need for separate washing and cleansing for removing or removing. The dissolvable film may be applied after dissolving it, or it may be dissolved directly after attachment to a site requiring management.

Specifically, the soluble film may be selected from the group consisting of pullulan, gelatin, agar, carrageenan, alginate, chitosan, chitosan derivatives, starch, galactomannan, glucomannan, guar gum, roaststool gum, pluronic, May include at least one polymer selected from the group consisting of polyvinylidene fluoride (PVP), polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyvinyl acrylic acid (PVAc), and polymethacrylic acid (PMAc) But is not limited thereto. More specifically, the film former may be comprised of pullulan and polyvinylpyrrolidone.

In addition, the soluble film composition containing the speckle may be one for skin regeneration, skin texture improvement, or promotion of skin absorption of the cosmetic composition.

Spicule penetrates into the basal layer of the skin to activate the therapeutic immune system of the human body, thereby helping regenerate the cells. In addition, it can reach the dermis layer when penetrating into the pores, thereby helping the cosmetic ingredient to be deeply transferred into the skin .

In the present invention, " skin regeneration " means a restoration process of skin tissue against damage caused by external or internal causes of the skin. Damage due to external causes may include ultraviolet rays, external contaminants, wound, trauma, etc. The damage caused by the internal causes may be stress.

In the present invention, "skin microrelief" means a three-dimensional microstructure formed by fine lines on the skin surface. It is an indicator of skin condition independent of elasticity, wrinkles and moisturizing. More specifically, skin texture is a reliable indicator of aging that can detect aging before aging begins. In addition, the skin texture reflects the state of the skin, not just the rough and smooth skin surface. The skin texture of the apparent skin surface is only part of the skin's entire structure. It is reflected.

The term " improvement of skin texture " refers to a process of restoring the skin texture if it is damaged.

In Example 1 of the present invention, it was confirmed that when the human skin fibroblast culture was treated with the spicule, the cell number increase effect was remarkably increased as compared with the control group not treated with the spicule (Table 2) The results are shown in FIG. 1, in which the wrinkles of the eyes are reduced and the skin texture is improved (FIG. 1).

The above results show that the soluble film containing the speckle of the present invention not only accelerates absorption of other cosmetic compositions in the skin but also exhibits both skin regeneration and skin texture improving effect itself, But also to be used alone.

In addition, the soluble film containing the speckle of the present invention may exhibit the effect of improving the skin regeneration and skin texture as described above, and also the skin elasticity enhancement and wrinkle improving effect which can be derived therefrom.

In the present invention, "skin elasticity" is expressed by elastic fibers composed of elastin existing in the dermal layer. Such elastic fibers have a very low elastic modulus such as rubber and are easily deformed by a small force, When the force is removed, it easily returns to the original shape. In addition, the elastic fibers have a form in which microfibrils are embedded in an amorphous matrix called elastin, and elastin is a protein that is found only in elastic fibers such as desmosine and isodesmosine derived from lysine, It is a protein composed of one amino acid. These desmosins and isodesmesynes form cross-links in long peptide chains, which makes elastin behave like a rubber.

In the present invention, "skin elasticity enhancement" means that elastic fibers composed of elastin are present together with collagen fibers called collagen, and elastic elasticity is maintained or increased in a state where elastin and collagen are sufficiently present.

The term "skin wrinkle" in the present invention means a skin caused by a decline in skin, which may be caused by a cause of a gene, a decrease in collagen and elastin present in the skin dermis, and an external environment.

In the present invention, "improvement of skin wrinkles" refers to inhibiting or inhibiting the generation of wrinkles on the skin, or alleviating already formed wrinkles.

In the present invention, the cosmetic composition capable of promoting skin absorption by a soluble film containing a speckle may be at least one selected from the group consisting of retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme quetin, elastin, collagen, hyaluronic acid, ceramide, Wherein the composition is selected from the group consisting of collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, alpha bissabolol, tocopherol, tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, vitamins A, D, E, But are not limited to, those containing one or more active ingredients.

In addition, the natural extract may be selected from the group consisting of aloe, green tea, ginseng, red ginseng, pearl, vinegar, pine leaf, ginkgo leaf, propolis, mulberry leaf, silkworm, snail slime, kakaduplum, camucam, yashiyama, squalane, caviar, broccoli, Berry, locust hanger, acerola, chlorella, mangosteen, guava, coriander, carrot, caffeine, hamamelis, spirulina, salmon roe, But are not limited to, those extracted from one or more selected from the group consisting of alfalfa, mallow, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, And may contain any cosmetic and / or nourishing ingredients capable of delivering a beneficial effect to the skin.

In addition, the cosmetic composition may be in the form of a solution, a lotion, a cream, a gel, an essence, a skin-adhesive type cosmetic, a lotion, an ointment, an oil, a suspension, an emulsion or a spray.

In Example 1 of the present invention, the skin permeability of the test group to which the dissolution film containing the speucule of the present invention was applied after application of the self-essence was measured (Example 3) As shown, when the dissolution film containing the spicule was applied onto the skin after applying the essence, it was confirmed that the essence transfer effect and the skin permeation promotion effect were significantly increased.

Accordingly, another aspect of the present invention is a cosmetic composition comprising: a) applying a cosmetic composition to the skin; And b) applying or adhering the soluble film composition onto the skin to which the cosmetic composition has been applied, thereby promoting skin absorption of the cosmetic composition.

The description of the specific cosmetic composition is as described above.

Another aspect of the present invention provides a cosmetic sheet comprising the above-mentioned soluble film composition. Specifically, the beauty sheet may be one for regenerating skin, improving skin texture, or promoting absorption of a cosmetic composition. Description of the skin regeneration, skin texture improvement or absorption promotion of the cosmetic composition is as described above.

Examples of the material that can be used as the support of the sheet include rayon, urethane, latex, acrylic, etc., but not limited thereto, and can be suitably modified and used by using woven fabric or knitted fabric or materials capable of minimizing exposure to the outside have.

Another aspect of the present invention provides a cosmetic patch for topical skin care comprising a soluble film composition comprising the speckle.

The term " topical skin " in the present invention refers to a skin of a specific part of a tissue, such as an eye, a mouth, a wrinkle, a clown, a ball, a chin, a hand, an elbow or a chest, Can be suitably manufactured in a size and shape necessary for managing the local skin as described above.

The above-mentioned "skin care" refers to an action for skin regeneration, skin texture improvement, skin elasticity enhancement, or skin wrinkle improvement, and is not limited thereto and may be included without limitation for improving skin texture or preventing aging.

In one embodiment of the present invention, it was confirmed that wrinkles of the eyes were reduced and the skin texture was improved as a result of attaching a soluble film containing a speckle to the eye area. (Fig. 1).

In the present invention, the " beauty sheet " or " beauty patch " can be utilized in various ways in use. It may be used as a method of impregnating the skin with the liquid containing the active ingredient (a component for moisturizing, anti-allergy, antibacterial, whitening, wrinkle improvement, etc.) and then attaching it to the skin and desorbing it after a certain period of time. The soluble film can be dissolved on the skin to penetrate the skin.

The soluble film composition containing the speckle of the present invention is excellent in skin regeneration or skin texture improving effect itself. In addition, the composition of the present invention exhibits an effect of accelerating the absorption of the cosmetic composition into the skin when the cosmetic composition is coated and then applied or applied thereto, so that the effect of the active ingredient of the cosmetic composition can be enhanced.

It should be understood that the effects of the present invention are not limited to the effects described above, but include all effects that can be deduced from the description of the invention or the composition of the invention set forth in the claims.

Fig. 1 is a comparative photograph of a soluble film containing a speckle before and after attachment. Fig.

Hereinafter, the present invention will be described in detail by way of examples. However, the following examples are illustrative of the present invention, and the present invention is not limited by the following examples.

Example  One. Spicular  Preparation of soluble film containing

The components described in Table 1 below were mixed to prepare a spinel-containing soluble film. Specifically, the ingredients of phase 1 were mixed at 75 ° C or higher, then the phase 2 was put into the mixture of phase 1, and the mixture was thoroughly mixed at a temperature of 75 ° C or higher for 40 to 50 minutes. The above-mentioned phase 2 is a component of the soluble film so that the content of the present invention can be produced in the form of a soluble film. Subsequently, the phase 3 was sufficiently dispersed and mixed in the mixture of Phase 1 and Phase 2 and mixed at a temperature of 75 ° C or more for 20 minutes. Phage / Phosphine-17/6 copolymer in Phase 3 was used as the dispersant in Phase 3, and hydroxypropylmethylcellulose was used to control the viscosity of the contents and to assist in the dispersion of the speckle. The mixture was then mixed up to phase 4 and cooled and defoamed at a temperature below 30 ° C. Spicule of the present embodiment was purchased and used by SPTIRIN HG (Spicule particle size: 80 mu m) manufactured by Risell Laboratories through ESTY TRADING.

Prize Ingredients Content (% by weight) function One Purified water 75.1 solvent Allantoin 0.1 Skin conditioner Trehalose 4 Moisturizer Polyglutamic acid 2 Moisturizer 2 Polyvinylpyrrolidone (PVP) One Film forming agent Pullulan 10 Film forming agent 3 glycerin 4 Moisturizer, dispersant Pigment / PPE-17/6 Copolymer One Moisturizer, dispersant Spicular 1.1 Skin conditioner Hydroxypropylmethylcellulose 0.6 Dispersant, viscosity modifier 4 Polysorbate 80 One Surfactants Spices 0.1 Spices

The uniformly prepared contents were coated on the release film to form a coating layer having a thickness of about 10 탆. Thereafter, a urethane foam cloth was disposed as a support on the upper surface of the formed coating layer and dried in a chamber at a temperature of 40 to 120 캜. The hydrophobic foam or sheet which can be used as a support is not only urethane but also latex, acrylic and the like, and can be appropriately modified and used if it can minimize exposure to the outside.

Experimental Example  1. Confirm skin regeneration effect

CCK (Cell counting kit) -8 assay was used to confirm skin regeneration effect through skin cell proliferation. Human skin fibroblasts were cultured in DMEM (Dulbecco's Modification of Eagle's Medium) medium supplemented with 10% FBS (fetal bovine serum) and 1% penicillin-streptomycin at 5% CO ₂ at 37 ° C. 1,000 human dermal fibroblasts were plated on a 96-well plate, and the cells were treated with the spleen, followed by confirming the degree of cell proliferation after 3 days. For the measurement, CCK-8 solution was added to the cell culture solution (100 μl / well), incubated for 3 hours in an incubator, absorbance was measured at 450 nm, and cell number increase was examined based on the standard curve. The results are shown in Table 2 below.

sample Cell number after 3 days Control group 2259 Experimental group (Spicular treatment) 5842

As shown in Table 2 above, when the spicule was treated and cultured for 3 days, the cell number increase effect was remarkably greater than that of the control group without spicule treatment. Therefore, it has been confirmed that when the soluble film containing the speckle of the present invention is applied to or adhered to the skin, it promotes the proliferation of the skin cells and can exhibit an excellent skin regeneration effect.

Experimental Example  2. Skin texture  Check the improvement

In order to examine the effect of improving the skin texture of the soluble film containing the speckle prepared in Example 1, the effect of improving skin texture after adhesion to the eye surface was observed once a day for 5 days. As a result, it was confirmed that the wrinkles of the eyes were reduced and the skin texture was improved as shown in Fig.

Experimental Example  3. Measurement of skin permeability of active ingredient

Experiments were conducted to confirm the skin absorption promoting effect of the active ingredient of the soluble film containing the speaclet prepared in Example 1 above. The skin permeability of the test group to which the dissolution film of Example 1 was applied was measured (Table 3).

sample Contents Control group Applying its own essence Experimental group After application of the self-essence, the solubility film of Example 1

Specifically, the dorsal skin of 8 to 10-week-old hairless mice was removed and the subcutaneous fat and tissues were removed with physiological saline, and then the skin was well spread and used for the experiment. The stratum corneum is put in the donor compartment of the hamster skin of Franz diffusion in the above-described hairless mouse skin, and then applied between the receptor compartments and then the essence is applied to the surface of the skin (control group) The soluble film of Example 1 was adhered (experimental group). In the recipient compartment, pH 7.4 phosphate buffered saline was added and stirring was continued at 300 rpm while maintaining the temperature at 37 ° C. At this time, the area of the skin contacting the recipient compartment was 2.0 cm 2, and the capacity of the recipient compartment was 5 ml. After 1.0 ml of each sample was administered to the skin surface, the sample was collected using a fraction collector.

All samples were filtered through a 13-mm disk filter (pore size 0.45 μm) before column injection and analyzed with a Waters 2690 alliance separation module (Waters, USA) with a photodiode array detector system 996 (Waters, USA) . Xterra RP18 (5 μ m, 4.6 x 205 mm, Waters, USA) column was used as a stationary phase. The mobile phase was methanol, water and acetic acid buffer in a mixed solvent of 10:80:10, flow rate of 0.8 ml / min Was detected at a wavelength of 280 nm. The analysis of the permeability of the essence was confirmed by measuring the flow amount of adenosine, which is a functional component for improving wrinkles contained in the essence.

The amount of adenosine accumulated per unit skin area was plotted against time, and the adenosine flux in the equilibrium state was calculated from the slope of the region showing linearity. The Lag time (T _L ) was determined from the time the straight line passed through the x-axis. The effect of the base film and the dissolution film of Example 1 was calculated by comparing the enhancement ratio (ER), the amount of adenosine flow in the equilibrium state, and the permeation coefficient using Equation 1 and Equation 2 below.

[Formula 1]

J _s is the adenosine flow in equilibrium, S is the area of permeation, (dQ / dt) _ss is the slope obtained by tabulating the amount of adenosine passing through the skin in equilibrium over time, C _d is the saturation concentration of adenosine , And K _p represents the transmission coefficient.

[Formula 2]

The skin permeability measured according to the above analysis method is shown in Table 4 below.

sample Delay time (hr) Adenosine flow
(ug / cm ² / hr) Percutaneous Transmittance (%) Percutaneous permeation promotion rate Control group 5.4 6.19 2.49 One Experimental group 2.2 113.22 29.16 34.44

As shown in the results of Table 4, when the dissolution film containing the spicule was applied onto the adhesive film and then adhered thereto, it was confirmed that the adenosine transfer effect and the skin permeation promoting effect, which are one of the effective components of the essence, It was found that the skin permeation effect on the cosmetic active ingredient of the dissolution film containing the speucule of the present invention was excellent.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims, and all changes or modifications derived from the meaning and scope of the claims and their equivalents should be construed as being included within the scope of the present invention.

Claims (12)

≪ / RTI > The soluble film composition of claim 1, wherein the speckle is comprised between 0.001% and 20% by weight of the total film composition. The soluble film composition of claim 1, wherein the particle size of the speckle is from 40 to 200 mu m. The method according to claim 1,
The above-
Starch, galactomannan, glucomannan, guar gum, locust bean gum, pluronic, algin, xanthan, gellan, polyvinylpyrrolidone (PVP) , At least one polymer selected from the group consisting of polyvinyl alcohol (PVA), polyethylene oxide (PEO), polyvinyl acrylic acid (PVAc) and polymethacrylic acid (PMAc) as film forming agents. 5. The method of claim 4,
Wherein the film forming agent comprises pullulan and polyvinyl pyrrolidone. The soluble film composition of claim 1, wherein the film composition is for regenerating skin, improving skin texture, or promoting skin absorption of a cosmetic composition. The cosmetic composition according to claim 6, wherein the cosmetic composition is at least one selected from the group consisting of retinol, retinyl palmitate, retinyl acetate, retinoic acid, coenzyme quetin, elastin, collagen, hyaluronic acid, ceramide, collagen, caffeine, chitosan, ascorbic acid, ascorbyl glucoside, Wherein the pharmaceutical composition comprises at least one active ingredient selected from the group consisting of alphabinol, tocopherol, tocopherol acetate, arbutin, niacinamide, adenosine, retinol acetate, vitamins A, D, E and natural extracts. [Claim 7] The method according to claim 7, wherein the natural extract is selected from the group consisting of aloe, green tea, ginseng, red ginseng, pearl, vinegar, pine leaves, ginkgo leaf, propolis, mulberry leaf, silkworm, snail slime, kakaduplum, , Broccoli, blueberry, location hazel, acerola, chlorella, mangosteen, guava, corn oil, carrot, caffeine, hamamelis, spirulina, salmon roe, gatti, giant kelp, Which is extracted from at least one member selected from the group consisting of raspberry, raspberry, chive, mulberry, edelweiss, chamomile, lavender, peppermint, eucalyptus, lemon balm, oregano, tea tree, Composition. a) applying the cosmetic composition to the skin; And
b) applying or adhering the soluble film composition of claim 1 on the skin to which the cosmetic composition is applied. A hairdressing composition comprising the soluble film composition of claim 1. The beauty sheet of claim 10, wherein the beauty sheet is for regenerating skin, improving skin texture, or promoting skin absorption of a cosmetic composition. A cosmetic patch for topical skin care comprising the soluble film composition of claim 1.

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