KR20180022440A - Thyroid Diagnostic Devices - Google Patents

Abstract

The present invention relates to a device for diagnosing thyroid cancer. More specifically, the device for diagnosing thyroid cancer comprises: a placement part to which a diagnostic kit injected with at least one sample of whole blood, plasma, and serum is attached and detached; a lighting part irradiating the sample with a light source; a photographing unit photographing the sample irradiated with the light source and generating image information; and a control part determining whether thyroid cancer is present based on the image information generated from the photographing unit. Thus, the loss of the light source can be minimized, and the sample can be inspected more precisely.

Description

{Thyroid Diagnostic Devices}

The present invention relates to an apparatus for diagnosing thyroid cancer.

Thyroid cancer is a cancer that is more prevalent among women than men, and the cancer incidence rate of National Cancer Information Center is 7.4% of total female cancer in 2002. According to recent reports from the Korean Thyroid Disease Society, it ranked fourth in the incidence of cancer in Korea as of 2006, and women are ranked first. Although the incidence of thyroid cancer is higher than that of other cancers, the early diagnosis and early survival rates are high.

Although the cause of thyroid cancer is known as radiation exposure and sex hormones, the precise cause has not yet been elucidated (Tronko ND, et al., Thyroid gland and radiation (Ukrainian-American Thyroid Project) 91-104; Robbins J, Schneider AB. Radioiodine-induced thyroid cancer: Studies in the aftermath of the accident at Chernobyl. Trends Endocrinol Metab 1998; 9: 87-94.).

It is very important to find a risk factor for thyroid cancer and use it to establish a preventive system for thyroid cancer. Furthermore, since early detection and surgery of thyroid cancer is very likely to be highly viable, it is also important to establish an early diagnosis method. Current screening of thyroid disease uses ultrasound, and no special precautions are known.

Prior art has been developed to solve the above problems.

(2-OH-E1) measured from a body sample of a population of each of the normal and thyroid cancer patients, and a hormone concentration- 2-methoxyestradiol (2-OH-E2), 2-methoxyestrone (2-MeO-E1), 2-methoxyestradiol - methyl ether (2-MeO-E2-3-methyl ether), and the concentration of the at least three hormones inputted through the input unit is used A diagnostic program module for calculating a sample value of the diagnostic object based on the statistics and comparing the sample value of the diagnostic object with the stored statistic to determine whether the thyroid cancer is present or progressed, It consists of a computer system including.

However, since it is necessary to detect three or more hormone concentrations, it takes a long time to diagnose abnormalities of thyroid function.

In particular, the concentration of the hormone requires the use of a separate measuring device.

Korean Registered Patent No. 10-1368952 (Publication date: 2014. 03. 03)

SUMMARY OF THE INVENTION The present invention has been conceived to solve the problems of the prior art described above, and it is an object of the present invention to provide a method and apparatus for accurately testing a sample by supplying a light source parallel to a central axis of a photographing unit to a sample, And it is an object of the present invention to provide a diagnostic apparatus for thyroid cancer which can identify the problem of thyroid function by a single photographing.

In order to achieve the above object,

A light source for irradiating the sample with a light source; a light source for irradiating the sample with the light source; And a controller for determining whether thyroid cancer is present based on the image information generated from the photographing unit.

The diagnostic kit may further include a sample detection unit for detecting at least one of the injection of the sample and the type of the sample.

The apparatus may further include a guide portion coupled with the seating portion to allow the seating portion to move, and a driving portion that moves the seating portion.

In addition,

A light source unit for emitting a light source; an illumination lens for converting a light source emitted from the light source unit into a planar light source of a directivity; and a part of the planar light source passing through the illumination lens is reflected and another part of the planar light source passes through the planar light source, And a reflector that is reflected parallel to the central axis.

In addition,

A first imaging lens that focuses the surface light source reflected by the reflection unit onto the sample, and a light source that is condensed on the sample passes through the first imaging lens and the reflection unit And a second imaging lens for imaging one light source with the imaging unit.

In addition,

And a filter unit that transmits only the excitation wavelength at which the light source has reacted with the sample before image formation.

In addition, a part of the seat part may further include a departure prevention part for preventing the diagnostic kit from flowing or departing from the seat part.

In addition,

Wherein the guide part is inserted into the seat part by inserting the separation preventing part into the seat part when the seat part is moved toward the photographing part in a state where the diagnostic kit is mounted on the seat part, And when it is moved in the opposite direction, the detachment preventing part may protrude to the outside of the seating part while leaving the guide part, thereby releasing the mounting of the diagnostic kit.

In addition,

And a slide roller for easily inserting the release preventing portion into the seating portion while preventing the release preventing portion from being worn.

The excitation wavelength may be a wavelength of 650 nm to 680 nm.

In addition,

The center wavelength of the light source may be a wavelength of 640 nm to 660 nm.

In addition,

And a guide roller which is in close contact with the seat portion to easily insert the seat portion.

According to the present invention, a light source parallel to the central axis of the photographing section is supplied to the sample, thereby minimizing the loss of light that is imaged.

In addition, it is possible to prevent the diagnostic kit from flowing when the diagnostic kit is moved.

In addition, if the seat portion is moved backward, the departure prevention portion can automatically fix the diagnostic kit, and when the seat portion is moved forward, the departure prevention portion is released, so that the seat portion diagnostic kit can be easily taken out.

In addition, by minimizing the friction between the departure prevention portion and the guide portion, it is possible to prevent the release preventing portion and the guide portion from being worn, and further, the seat portion can be prevented from flowing from the guide portion.

In addition, energy can be saved by minimizing unnecessary operations by confirming the presence or absence of the sample.

1 is a perspective view schematically showing an apparatus for diagnosing thyroid cancer according to an embodiment of the present invention.
FIG. 2 is a perspective view of a part of a diagnostic apparatus for a thyroid cancer according to an embodiment of the present invention; FIG.
3 is a perspective view schematically showing a photographing unit and a sample detecting unit in a thyroid cancer diagnostic apparatus according to an embodiment of the present invention.
FIG. 4 is a perspective view illustrating a seat portion disassembled in the apparatus for diagnosing thyroid cancer according to an embodiment of the present invention. FIG.
FIG. 5 is a perspective view schematically showing an operating state of a thyroid cancer diagnosis apparatus according to an embodiment of the present invention; FIG.
FIG. 6 is a side view schematically showing an operation state of a photographing unit and an illumination unit in the apparatus for diagnosing thyroid cancer according to an embodiment of the present invention; FIG.
FIG. 7 is a perspective view schematically showing a state in which a departure prevention part is applied to a seat part in a thyroid cancer diagnosis apparatus according to an embodiment of the present invention; FIG.
FIG. 8 is a bottom view schematically showing an operation state of the departure prevention portion in the thyroid cancer diagnosis apparatus according to the embodiment of the present invention. FIG.

The preferred embodiments of the present invention will be described in more detail with reference to the accompanying drawings, in which the technical parts already known will be omitted or compressed for the sake of brevity.

1 to 9, a thyroid cancer diagnosis apparatus according to an embodiment of the present invention includes a base unit 1, a driving unit 2, a guide unit 3, a seating unit 4, an optical block 5 A photographing unit 6, a sample detecting unit 7, an illuminating unit 8, a sensor unit 30, and a control unit 9. And may further include the departure-avoiding portion 10 here.

The base portion 1 is provided with a bracket 11 for supporting a drive shaft 22, a rotation shaft 23 and a guide portion 3 to be described later on an upper surface of a substantially rectangular panel and a panel. At this time, two pairs of brackets 11 are provided and a pair of brackets 11 are installed on the upper surfaces of both sides of the panel.

The base unit 1 includes a drive unit 2, a guide unit 3, a mount unit 4, a photographing unit 6, a sample detection unit 7, an illumination unit 8, a sensor unit 30, And accommodates and supports the control unit 9.

The driving unit 2 includes a motor 21, a driving shaft 22, a rotating shaft 23, and a timing belt 24, which are controlled by the control unit 9 to move a seat 4 to be described later .

The motor 21 is installed on the rear upper surface of the base portion 1 using a generally known or known step motor 21 or the like.

The motor 21 is controlled by the control unit 9 and the shaft of the motor 21 is connected to the drive shaft 22 through a gear.

Accordingly, when the motor 21 is operated, the drive shaft 22 rotates.

The drive shaft 22 rotates the timing belt 24 to be described later and is rotatably held by the bracket 11 disposed at the rear of the base portion 1. The drive shaft 22 is rotatably supported by the bracket 11, Axis.

A gear corresponding to the timing belt 24, which will be described later, is formed in the middle of the drive shaft 22.

The rotation shaft 23 supports the timing belt 24 to be described later and is rotatably held by the bracket 11 disposed in front of the base portion 1 and is rotatably supported by the timing belt 24 Is formed.

The timing belt 24 moves the seat portion 4 so that a gear is formed inside and is engaged with the drive shaft 22 and the rotation shaft 23.

Thus, when the drive shaft 22 rotates, the timing belt 24 rotates, and when the timing belt 24 rotates, the rotation shaft 23 rotates.

The guiding portion 3 guides the seating portion 4 and is formed in the shape of an elongated bar so that a guide groove 31 corresponding to the seating portion 4 is formed in the upper portion of the guiding portion 3 in the longitudinal direction Is screwed to the bracket 11, and is disposed at the upper end of the bracket 11. As shown in Fig.

The guide section 3 is opened at the bottom of the bottom of the guide groove 31 so that the seating section 4 to be described later is connected to the timing belt 24.

The seating part 4 is attached to the guide groove 31 of the guide part 3 by moving the diagnostic kit 20 and is connected to the timing belt 24, Prevention block 42 and a fixed block 43. [

Further, the seat portion 4 moves forward or backward as the timing belt 24 rotates.

The seating block 41 is formed in a long bar shape and a kit insertion hole 411 corresponding to the diagnostic kit 20 is formed in the longitudinal direction on the top of the seating block 41, The guide grooves 31 are formed in the guide grooves 31, respectively.

The separation prevention block 42 prevents the diagnostic kit 20 from being separated from the upper and rear portions of the seating block 41. The separation prevention block 42 is formed in a shape of a substantially " And is screwed to the rear of the seating block 41. [

The release prevention block 42 protrudes from the rear end portion of the release prevention block 42 so that the sensor portion 30, which will be described later, detects the initial position of the seating portion 4. [

Thus, when the diagnostic kit 20 is inserted into the mounting block 41, the rear end portion of the diagnostic kit 20 is sandwiched between the mounting block 41 and the escape prevention block 42 and the rear end of the diagnostic kit 20 Is brought into close contact with the departure prevention block (42).

The fixed block 43 is divided into two parts, and two parts are fixed by screwing to one part of the timing belt 24. [

The upper end of the fixing block 43 is screwed and fixed to the bottom surface of the seating block 41.

Thus, when the timing belt 24 rotates, the seat portion 4 moves forward or backward.

The optical block 5 accommodates the imaging section 6, the sample detection section 7 and the illumination section 8 to be described later and is formed in a substantially rectangular parallelepiped housing shape and is screwed onto the upper surface of the guide section 3 .

The photographing section 6 photographs the specimen S injected into the diagnostic kit 20 and is arranged behind the inside of the optical block 5 and is controlled by the control section 9, A first imaging lens 62, a second imaging lens 63, and a filter unit 64. The first imaging lens 62,

The imaging element 61 is used for imaging the sample S and is controlled by the control unit 9 using a generally known or known photodetector or imaging element or the like and is provided at the rear upper end of the optical block 5 do.

The first imaging lens 62 is disposed at the lower end of the optical block 5 to receive a surface light source from an optical unit to be described later and focus it on the sample S.

The first imaging lens 62 transmits the light beam from the sample S to the second imaging lens 63.

The second imaging lens 63 is disposed between the imaging section 61 and the filter section 64 to be described later and collects the rays of light transmitted from the first imaging lens 62 and forms an image on the imaging section 61.

The filter portion 64 is disposed between the second imaging lens 63 and a reflective portion 83 to be described later, using a well-known or known band-pass filter or the like.

The filter section 64 is for transmitting only the excitation wavelength at which the light focused on the sample S reacts with the sample S and transmits only the wavelength of 660 nm to 670 nm.

The first imaging lens 62 and the second imaging lens 63 may be the same as known or known aspherical lenses.

The sample detector 7 detects the presence or absence of the sample S and the type of the sample S in the diagnostic kit 20 and is arranged inside the optical block 5 and controlled by the controller 9 do.

Here, the sample detecting unit 7 has the same configuration as the imaging unit 61, the first imaging lens 62, and the second imaging lens 63 of the imaging unit 6 described above, and the arrangement according to the height is the same. However, the sample detector 7 is provided with a green LED 71 at the lower end of the optical block 5.

That is, the sample detector 7 irradiates the sample S with the light source output from the green LED 71 and captures the sample. Then, based on the information photographed by the control unit 9, whether or not the sample S is contained in the diagnostic kit 20 is first determined. If it is determined that the sample S is present, the control unit 9 determines the type of the sample S, such as blood, whole blood, plasma, and serum, based on the information photographed by the control unit 9.

Here, the sample detector 7 corresponds to the configuration of the photographing unit 6 described above, and a detailed description thereof will be omitted.

The illumination unit 8 supplies a light source to the sample S and is disposed on the inner left side of the optical block 5 and includes a light source unit 81, an illumination lens 82, and a reflection unit 83.

The light source unit 81 is disposed in the inner left side of the optical block 5, and is disposed toward the reflection unit 83, which will be described later, using a generally known or known laser diode or the like, and the central wavelength of the light source is 650 nm.

The illumination lens 82 converts a light source output from the light source unit 81 into a plane light source of a direct-current type and is disposed between the light source unit 81 and the reflection unit 83.

The reflecting portion 83 reflects 50% of the light source while transmitting the remaining 50%, and is disposed between the first imaging lens 62 and the filter portion 64 in an inclined manner.

That is, when the surface light source output through the illumination lens 82 is irradiated on the reflection unit 83, 50% of the surface light source is reflected through the reflection unit 83 and reflected toward the sample S, and the remaining 50% And transmits the reflection portion 83.

The surface light source reflected toward the sample S is parallel to the central axes of the first imaging lens 62 and the second imaging lens 63 and passes through the first imaging lens 62, .

Accordingly, since the light source is irradiated perpendicularly to the sample S, it is possible to minimize the loss of the light that is formed, and furthermore, to photograph the sample S precisely. Based on this, the diagnosis of thyroid cancer can be more accurately diagnosed .

The sensor unit 30 detects the initial position of the seat portion 4 and is connected to the control unit 9. [

The sensor unit 30 is disposed on the upper surface of the base unit 1 but behind the guide unit 3.

Accordingly, when the seat portion 4 moves backward along the guide portion 3, the protruding portion of the escape prevention block 42 enters the sensor portion 30. [ At this time, the sensor unit 30 generates a signal, and the control unit 9 receives the signal to initialize the position of the seat 4. A description thereof will be described later.

The control unit 9 is disposed on the upper surface of the base unit 1 and disposed on the left side of the guide unit 3 and includes the driving unit 2, the photographing unit 6, the sample detection unit 7, the illumination unit 8, And the sensor unit 30 to determine the presence or absence and the type of the sample S and the presence or absence of the thyroid cancer.

The departure prevention portion 10 prevents the diagnostic kit 20 from moving slightly toward the front of the seating portion 4 after the diagnostic kit 20 is inserted into the seating portion 4, And is rotatably mounted on both sides of the seat portion 4. [

The release preventing portion 10 includes a rotating piece 101, a protruding piece 102, a stopper 103, and a sliding roller 104.

First, a mounting groove 412 corresponding to the departure-avoiding portion 10 is formed on the front both side bottom surfaces of the mounting block 41 'so that the departure preventing portion 10 is installed. The mounting groove 412 communicates with the kit insertion hole 411 A through hole 413 corresponding to the projecting piece 102 is formed.

The rotating piece 101 is formed in a substantially "B" -shaped shape and the rear end of the rotating piece 101 is rotatably attached to the mounting groove 412 of the mounting block 41 '. Thus, the rotating piece 101 rotates from the mounting block 41 'and protrudes or comes in from the mounting groove 412.

The protruding piece 102 is formed on the front end of the rotating piece 101 and protrudes toward the kit insertion hole 411 and is fitted into the through hole 413 of the mounting block 41 '. Accordingly, when the rotating piece 101 rotates, the protruding piece 102 protrudes through the through hole 413 into the kit insertion hole 411 or enters the through hole 413.

The stopper 103 limits the rotation section of the rotation piece 101 and is formed protruding rearward at the rear end of the rotation piece 101. [ Thus, when the rotating piece 101 rotates and protrudes from the mounting groove 412, the rotation of the rotating piece 101 is restricted by the stopper 103 being inserted into the mounting groove 412 and engaged. Therefore, it is possible to prevent the rotating piece 101 from being excessively projected to the outside of the seating block 41 '.

Here, the release preventing portion 10 or the seating block 41 'may be provided with a spring (not shown) for projecting the separation preventing portion 10 out of the seating block 41'. That is, when the seating block 41 'is moved backward in a state where the separation preventing portion 10 protrudes from the seating block 41', the rotating piece 101 is brought into close contact with both sides of the guide groove 31 . When the mounting block 41 is moved backward, both side surfaces of the guide groove 31 push the rotating piece 101 and the escape preventing portion 10 is inserted into the mounting groove 412. At this time, the protruding piece 102 protrudes into the kit insertion hole 411 and protrudes forward from the diagnostic kit 20, so that the diagnostic kit 20 can be firmly fixed.

The sliding rollers 104 are provided on the side of the front end of the rotary piece 101 to prevent the outer side surface of the release preventing portion 10 and both side surfaces of the guide groove 31 from being worn. At this time, the sliding roller 104 is installed so that the peripheral portion thereof can be rotated while being protruded to the outside of the rotating piece 101. The slide roller 104 is brought into close contact with both sides of the guide groove 31 and the slide roller 104 is rotated when the seat 4 is moved . Therefore, by minimizing the frictional force between the separation preventing portion 10 and the guide portion 3, it is possible to prevent the separation preventing portion 10 and the guide portion 3 from being worn.

On the other hand, the guide portion 3 may be further provided with a guide roller 32 on a front inner surface of the guide groove 31. That is, the guide roller 32 pushes the rotating piece 101 to pull the separation preventing portion 10 into the mounting groove 412, thereby further preventing the rotating piece 101 from being worn.

The diagnostic kit 20 includes a sample inserting hole 201 in the form of a bar having a substantially rectangular parallelepiped shape in which a sample S is injected into a rear upper surface thereof, (202) is formed in front of the sample injection port (201), and is fitted in the kit insertion hole (411) of the seat part (4). A description thereof will be described later.

Hereinafter, an operation of the thyroid cancer diagnostic apparatus according to an embodiment of the present invention will be described with reference to the accompanying drawings.

The switch for driving the present invention is omitted. However, since the switch for driving the device is self-explanatory, it is assumed that there is a switch in order to explain the operation state of the present invention.

When the switch is turned on, the seat portion 4 moves backward, and the sensor portion 30 senses the initial position.

After detecting the initial position of the seat 4, the control unit 9 sets the movement distance of the seat 4 and drives the motor 21 to move the seat 4 forward.

When the seat portion 4 moves forward, the front portion of the seat portion 4 moves out of the guide portion 3, and the departure prevention portion 10 projects to both sides.

A sample (blood) is injected into a sample injection port 201 after the seat part 4 protrudes forward of the guide part 3 and then the diagnostic kit 20 is inserted into the seat part 4. [

When the diagnostic kit 20 is inserted into the seat 4, when the switch is operated again, the seat 4 moves backward.

The detachment preventing portion 10 is automatically drawn into the seating portion 4 and the protruding piece 102 is projected into the kit insertion hole 411 and the diagnostic kit 20, .

Subsequently, the seat 4 is moved backward and stopped at a position where the sample inlet 201 and the sample detector 7 coincide with each other.

When the seat 4 stops, the sample detector 7 detects whether or not the sample S exists.

Thereafter, the photographing section 6 moves the mount section 4 backward so as to photograph the specimen S reacted in the specimen inspecting section 202.

When the seat part 4 moves backward, the illuminating part 8 operates, and when the illuminating part 8 operates, the photographing part 6 operates.

When the light source unit 81 outputs a light source, the light is converted into a planar light source while passing through the illumination lens 82, and the planar light source is irradiated to the first imaging lens 62 through the reflection unit 83.

The plane light source is focused on the sample S while passing through the first imaging lens 62, and a focus is generated on the sample S.

The light source including the excitation wavelength is generated by the first imaging lens 62, the reflecting section 83, the filter section 64, and the second imaging lens 63 Pass sequentially.

Here, when the light source passes through the filter section 64, only the excitation wavelength is passed through, and only the excitation wavelength is imaged at the image formation section 61, and the image formation section 61 takes this image.

At this time, it is also possible to successively photograph the sample S while the seat portion 4 moves slightly backward.

Thereafter, the control unit 9 receives the photographed information from the imaging unit 61 and discriminates the abnormality of the thyroid function.

When the discrimination is finished, the seat part 4 moves backward, recognizes the position of the seat part 4 by the sensor part 30, and the control part 9 initializes the position of the seat part 4. [

The seat 4 is moved forward when the seat 4 is initialized and the seat 10 is automatically opened when the seat 4 is protruded from the guide 3. [

The diagnostic kit 20 can be easily detached from the seat portion 4 when the departure prevention portion 10 is opened.

In describing the present invention described above, the same reference numerals are used for the same configurations even if the embodiments are different, and the description thereof may be omitted if necessary.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments. Shall not be construed as being understood. Therefore, those skilled in the art will appreciate that various modifications, additions and substitutions are possible, without departing from the scope and spirit of the invention as disclosed in the accompanying claims. The present invention is not limited thereto.

One; Base portion
11; Bracket
2; The driving unit
21; motor
22; driving axle
23; Rotating shaft
24; Timing belt
3; Guide portion
31; Guide groove
32; Guide roller
4; Seat portion
41, 41 '; Seating block
411; Kit insert hole
412; Mounting groove
413; Through-hole
42; Departure prevention block
43; Fixed block
5; Optical block
6; Shooting section
61; Texture
62; The first imaging lens
63; The second imaging lens
64; The filter unit
7; The sample detector
71; Green LED
8; Illumination unit
81; Light source
82; Lighting Lens
83; Reflection portion
9; The control unit
10; The departure-
101; Rotation piece
102; Projecting pieces
103; stopper
104; Sliding roller
20; Diagnostic Kit
201; Sample inlet
202; Sample Inspection Section
30; The sensor unit
S; sample

Claims (9)

A mounting part for detaching a diagnostic kit into which a sample of blood, whole blood, plasma, and serum is injected;
An illumination unit for irradiating the sample with a light source;
A photographing unit photographing the sample irradiated with the light source to generate image information; And
And a controller for determining whether or not thyroid cancer is present based on the image information generated from the photographing unit
Diagnostic device for thyroid cancer.
The method according to claim 1,
And a sample detector for detecting at least one of the injection of the sample and the type of the sample in the diagnostic kit.
Diagnostic device for thyroid cancer.
The method according to claim 1,
A guide portion that engages with the seat portion so that the seat portion can be moved; And
And a driving unit for moving the seating part
Diagnostic device for thyroid cancer.
The method according to claim 1,
The illumination unit includes:
A light source unit for emitting a light source;
An illuminating lens for converting a light source emitted from the light source unit into a planar light source of a directivity; And
And a reflective portion through which a part of the planar light source passing through the illumination lens is reflected and another portion is reflected while the planar light source is reflected in parallel with the central axis of the photographing portion
Diagnostic device for thyroid cancer.
The method according to claim 1,
Wherein,
An imaging unit for imaging the sample to generate image information;
A first imaging lens that focuses the surface light source reflected through the reflective portion onto the sample; And
And a second imaging lens that forms a light source that has been condensed on the sample through the first imaging lens and the reflection section to the imaging section
Diagnostic device for thyroid cancer.
6. The method of claim 5,
Wherein,
And a filter unit which transmits only the excitation wavelength at which the light source has reacted with the sample before being imaged
Diagnostic device for thyroid cancer.
The method of claim 3,
And a separation preventing part for preventing the diagnostic kit from flowing or being separated from the seating part to a part of the seating part
Diagnostic device for thyroid cancer.
8. The method of claim 7,
The departure-
Wherein the guide part is inserted into the seat part by inserting the separation preventing part into the seat part when the seat part is moved toward the photographing part in a state where the diagnostic kit is mounted on the seat part, And when it is moved in the opposite direction, the detachment preventing part is protruded to the outside of the seating part while leaving the guide part, so that the mounting of the diagnostic kit can be released.
Diagnostic device for thyroid cancer.
8. The method of claim 7,
The departure-
And a sliding roller for easily inserting the release preventing portion into the seating portion while preventing the separation preventing portion from being worn out
Diagnostic device for thyroid cancer.

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