KR20170103517A - Composition for prevention or treatment of oral disease comprising Prunus yedoensis Matsumura extract - Google Patents

Abstract

The present invention relates to a composition for preventing, ameliorating or treating an oral disease, which comprises a mildew extract, and relates to a composition for preventing, ameliorating or treating oral diseases, which has a safe and excellent effect on the human body.

Description

[0001] The present invention relates to a composition for preventing or treating oral diseases,

TECHNICAL FIELD The present invention relates to a composition for oral administration, and more particularly, to a composition which is safe for human body and is excellent in prevention, improvement, or treatment of oral diseases such as dental caries, periodontal disease, bad breath,

In oral disease, dental caries and periodontal disease are known to cause various clinical symptoms such as pain, chewing dysfunction, periodontal tissue destruction, bad breath and saline, and are known to cause tooth loss. Cause factors are increasing.

It is a method to inhibit the growth of oral pathogens causing dental caries, periodontal disease, bad breath, and syringe while living in the dentine bacterial membrane. Various kinds of antimicrobial agents including antibiotics having bactericidal and bacteriostatic action for these bacteria , ≪ / RTI > size, and apical < RTI ID = 0.0 > infection. ≪ / RTI >

However, since antibiotics can cause systemic adverse effects on the body and cause the appearance of resistant bacteria and oral hyposensitization in oral cavity, it is difficult to use for a long period of time and can only be used as a therapeutic agent. In addition, the antimicrobial agents used in the oral cleanser include raw niacin, listerine, pyroxide, and chlorhexidine. Sangquinarine is not clear for the bacteria in the oral cavity, and its therapeutic effect in periodontal disease is further unclear Listerine is a major ingredient in alcohol. It has a temporary effect in the oral cavity, but it has a slight bacteriostatic action. However, it has a disadvantage that it can show a harmful effect on tissues during long-term use. Peroxide, which is added for the whitening effect, is poisonous to bacteria, but at the same time, toxic to human tissues, it is not only a safety problem, but also bacteria appear to be resistant to pyroxide in bacteria. Chlorhexidine is known to be one of the best known agents for the prevention and treatment of periodontal disease in addition to the prevention of periodontal disease. However, it is known that the stimulation of the tissue, pigmentation and degeneration of tissues, and especially the irritating taste, In addition, there is a disadvantage that it can not be used for a long period of time for the purpose of treatment or especially prevention, such as that there is a problem that it is caused by mutation,

Symptoms of dental caries, or dental hypersensitivity, are symptoms of toothache when eating fresh fruit or drinking cold water, which can lead to destruction of enamel and cement due to incorrect brushing, The dentinal tubules that were protected by the gums are exposed. In order to improve symptoms of such acne, a toothpaste for preventing acne has been developed and the dentinal tubules exposed by the dentistry are treated with a resin. However, a conventional toothpaste using a conventional ivory tubular sealing effect contains a fine powder of an effective ingredient to seal the ivory tubule. In general, the toothpaste is diluted in the process of brushing, and is washed away most of the time in the course of rinsing with water There is a problem in that the customs pipe is not sealed and exposed again.

Accordingly, the present inventors have conducted studies to derive an ingredient which is not harmful to the human body and which is harmless to human body, and is excellent in prevention and improvement of oral diseases such as dental caries, periodontal disease, bad breath,

Accordingly, the present invention aims at solving the above problems and providing such a useful use of a new active ingredient, that is, an active ingredient, which is less harmful to the human body and can inhibit the growth of bacteria in the oral cavity.

In other words, a problem to be solved by the present invention is to provide a composition comprising the active ingredient having excellent efficacy as an active ingredient, particularly a composition for oral care for preventing or improving dental caries, periodontal disease, or bad breath.

The present invention provides a composition for treatment or improvement of oral diseases using a naturally occurring ingredient that is safe and safe to use in the body.

The present invention provides a composition for oral cavity, which can relieve symptoms of acne by forming a coating film on the surface of a damaged tooth using a natural material.

In order to solve the above problems, the present invention provides an oral composition derived from a natural substance. Specifically, perianth (Prunus In one embodiment of the present invention ydooensis Matsumura ) as an active ingredient.

That is, the present invention provides a novel composition for oral care compositions containing horns, particularly oral compositions for preventing, improving or treating various oral diseases.

The inventors of the present invention have conducted studies for development of an oral composition capable of exhibiting effects on the treatment, prevention and improvement of diseases in the oral cavity by harmless to the human body. In particular, And a tooth surface coating effect, and completed the present invention. Through the continuous research process of the inventors of the present invention, it was possible to first identify the treatment or prevention effect of the oral extract of the present invention on oral diseases.

The method of using the husk is not particularly limited, and may be included in the oral composition as a powder after drying and, preferably, it may be contained in the oral composition as an extract.

As used herein, the term "extract" refers to an extract obtained by extracting the hulls, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a controlled preparation or a purified product of the extracted solution, Extracts themselves and extracts of all formulations which can be formed using extracts.

The peony extract of the present invention can be extracted from various organs of natural, hybrid, or variant plants of the fern, and can be extracted, for example, from the bark of the ground, stem, leaf, and fruit.

In the above extract of hornblende of the present invention, the method for extracting the hornbill is not particularly limited, and may be extracted according to a method commonly used in the art. Examples of the extraction method include hydrothermal extraction method, ultrasonic extraction method, filtration method, and reflux extraction method. These methods may be carried out singly or in combination of two or more methods, preferably using a hot water extraction method .

The kind of the extraction solvent used for extracting the hulls in the present invention is not particularly limited, and any solvent known in the art can be used. Nonlimiting examples of the extraction solvent include water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, hydrochloric acid, And cyclohexane. In the case of using alcohol as a solvent, C ₁ to C ₄ alcohols (methanol, ethanol, propanol, butanol) can be preferably used. In the present invention, water, ethanol or a mixture thereof may be used as the solvent for extracting the horn.

In the present invention, the composition may be for preventing, improving or treating oral diseases.

In the present invention, the oral diseases include, for example, but not limited to, oral malodor, which may be caused by oral microorganisms, periodontal diseases including dental caries, gingivitis and periodontitis, and oral mucosal ulcers. Concept.

In addition, the oral disease may include various oral diseases which may be caused by external physical stimulation as well as by oral microorganisms. For example, dental caries may be exposed due to tooth surface wear, Syphilis can also include symptoms.

As used herein, the term " treatment " in the present invention refers to an approach to obtaining beneficial or desired clinical results, which may or may not be able to detect beneficial or desired clinical results for the purposes of the present invention, Including, but not limited to, relieving symptoms, decreasing the severity of the disease, stabilizing (i.e., not becoming worse) conditions of the disease, delaying or slowing the progression of the disease, improving or temporarily alleviating and alleviating the disease state, But is not limited thereto. Thus, treatment refers to both therapeutic treatment and prophylactic measures, and those that need treatment include conditions that already have the disease, as well as conditions in which the disease is to be prevented. It may also refer to any action that may improve or improve the symptoms of oral diseases by administering the pharmaceutical composition of the present invention to a subject.

"Prevention" may refer to any act that inhibits or delays disease using the oral composition. The oral composition may be used in the form of a pharmaceutical composition, a food composition, or an oral care composition, but is not necessarily limited thereto.

As used herein, the term "improvement" means that the above symptom is reduced or relieved, and can be understood as a broad concept including mitigation, prevention, and treatment.

As used herein, the term "bad breath" may refer to symptoms of unpleasant odors in the mouth, including, but not limited to, volatile sulfur compounds, An unpleasant smell may be caused in the mouth.

As used herein, the term "dental caries" refers to dental caries in which tooth enamel is damaged by acid generated by degradation of sugar and starch by bacteria in the mouth, resulting in tooth decay. The caries can be caused by various causes, for example, a plaque, which is a bacteria film formed on the tooth surface. When food is consumed, food residue remains in the mouth. If the acid generated by the decomposition of sugar or starch remaining in the mouth by plaque bacteria attacks the enamel of the tooth surface, dental caries can occur.

As used herein, the term "periodontal disease" is an oral disease involving gingivitis and periodontitis, depending on its degree, including but not limited to attack of bacteria below the gum line of the sulcus, It may appear to damage adjacent tissue.

The term "oral mucosal ulcer ", as used herein, is also referred to as stomatitis, and includes, but is not limited to, oral mucosa (tongue, gums, lips, And the like).

The oral disease may be caused by bacteria, and the bacterium may be a bacterium such as Streptococcus sp., Porphyromonas sp.

The composition for oral use of the present invention is useful for the treatment or prophylaxis of diseases caused by or associated with the genus of Streptococcus or Porphyromonas and more particularly Streptococcus mutans, Streptococcus sanguis, Streptococcus mutans, sanguinis, Streptococcus salivarius subsp. thermophils, and Porphyromonas gingivalis are excellent antibacterial effects to prevent, improve or prevent oral diseases It can have an excellent effect on the treatment.

More preferably, the oral composition of the present invention may exhibit an antibacterial effect on Streptococcus mutans or Porphyromonas gingivalis bacteria.

According to another embodiment of the present invention, the herbal extract of the present invention is included in a composition for preventing, ameliorating or treating symptoms of schizophrenia.

As used herein, the term "syringe" refers to all phenomena, including, but not limited to, sharp, transient, or persistent pain to external stimuli, independent of tooth decay or other pathological causes. The external stimulus usually refers to a temperature stimulus, which is often accompanied by a cold temperature stimulus, which may cause pain at a hot temperature. In addition to such temperature stimuli, pain may also be caused by irritation, such as drying of teeth, contact with foreign substances, or osmotic pressure through sweet or new foods. It may appear entirely on the entire tooth and may be confined to specific areas such as the maxilla or mandible, right or left, dentine hyperesthesia, caries, or dental inflammation.

The cause of this symptom is considered to be the exposure of the mouth of the ivory tubule.

When the enamel or cementum is destroyed and the entrance of the dentinal tubule is exposed to the outside, the stimulation is transmitted to the dimension by the cell protrusion, nerve and dentin liquid of the dentinal tubule, and the pain can be felt.

The inventors of the present invention have found that the extract of Mulberry can react with calcium ion contained in the needle to form a coating film on the teeth surface and that the formed coating film prevents exposure of ivory tubule to prevent, Respectively.

The composition for preventing or treating oral diseases of the present invention can be directly applied to animals including humans. The animal is a biological group corresponding to a plant. It mainly consumes organic matter as nutrients, and has digestion or excretion and differentiation of the respiratory organs. Preferably, it may be a vertebrate, more preferably a mammal. Specifically, the mammal may be a human, a pig, a cow, or a goat. The composition for the prevention or treatment of oral diseases may contain the peony extract alone as an active ingredient and may further contain additional components such as a pharmaceutically acceptable or nutritionally acceptable carrier and excipient depending on the formulation, , A diluent or a subcomponent.

More particularly, the composition for preventing or treating oral diseases may further comprise, in addition to the active ingredient, a nutritional agent, a vitamin, an electrolyte, a flavoring agent, a colorant, a thickening agent, a pectic acid and a salt thereof, an alginic acid and a salt thereof, , a pH adjusting agent, a stabilizer, a preservative, a glycerin, an alcohol, and a carbonating agent used in a carbonated drink. The carrier, excipient or diluent may be selected from lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acicia gum, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline In the group consisting of celluloses, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil, dextrin, calcium carbonate, propylene glycol, liquid paraffin, But the present invention is not limited thereto. Any conventional carrier, excipient or diluent may be used.

The composition for preventing or treating oral diseases may further comprise conventional fillers, extenders, binders, disintegrants, surfactants, anti-coagulants, lubricants, wetting agents, flavoring agents, emulsifiers or preservatives, Both parenteral use can be used.

Particularly, solid preparations for oral administration include tablets, pills, powders, granules, capsules and the like. These solid preparations may contain at least one excipient such as starch, calcium carbonate, Sucrose, lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Examples of liquid formulations for oral use include suspensions, solutions, emulsions, syrups and the like. In addition to water and liquid paraffin which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included .

Examples of the form for parenteral administration include toothpastes, mouthwashes, topical administration agents (creams, ointments, dressing solutions, sprays, and other coating agents). An example of the formulations of the topical administration agent may be a composition for preventing or treating oral diseases, which comprises an extract of a mildew as an active ingredient, impregnated with a carrier such as gauze made of natural fibers or synthetic fibers.

In the case of the cream or ointment, it may be suitable for direct application to periodontal disease, gingival disease, or cavities or their surroundings. In the case of the above-mentioned spray agent, it can be manufactured by a conventional spray agent manufacturing method except that it contains an extract of hwangpi as an active ingredient, and it is packed in a compression vessel or other spray vessel to spray the oral disease site Or can be treated. In the case of the dressing solution, the dressing solution can be prepared by a conventional dressing solution manufacturing method except that it contains the extract of huangsu as an active ingredient. The dressing solution can be used for dressing or oral dressing on the oral disease site, Prevention or treatment.

In addition, the formulation of the composition for preventing or treating oral diseases according to the present invention may be in a desired form depending on the method of use, and may be formulated so as to provide rapid, sustained or delayed release of the active ingredient, The method can be adopted. Exemplary formulations include, but are not limited to, excipients, granules, lotions, liniments, rimonadense, powders, syrups, solutions, aerosols, EXTRACTS, elixirs, ointments, Suspensions, tablets, capsules, creams, pills, soft or hard gelatine capsules, and the like.

Furthermore, the compositions for the prevention or treatment of oral diseases of the present invention can be prepared by any of the known methods known in the art or by a method disclosed in Remington's Pharmaceutical Science (recent edition), Mack Publishing Company, Easton PA And the like.

The dosage of the composition for preventing or treating oral diseases according to the present invention can be suitably selected by those skilled in the art in consideration of the administration method, the age, sex and weight of the recipient, severity of the disease, and the like. For example, the composition for preventing or treating oral diseases according to the present invention may be administered at a dose of 0.0001 mg / kg to 1000 mg / kg, and 0.01 mg / kg to 100 mg / kg, to be more effective. The administration may be carried out once a day or divided into several times. The dose is not intended to limit the scope of the invention in any way.

In addition, the composition for preventing or treating oral diseases according to the present invention may further comprise a compound having a known oral disease-inhibiting activity or a plant extract, in addition to the extract of mosses, and the content thereof may be determined depending on the preparation method and the intended use.

In one embodiment of the present invention, there is also provided a food composition for preventing or improving oral diseases, comprising a mildew extract as an active ingredient. Examples of the food composition of the present invention include foods, food additives, beverages or beverage additives.

The food composition containing the mushroom extract as an active ingredient may further contain suitable carriers, excipients and diluents conventionally used in the production thereof.

As used herein, the term " food " means a natural product or a processed product containing one or more nutrients. Preferably, it means that the food can be directly eaten through a certain degree of processing. It is intended to include food, food additives, health functional foods and beverages.

Foods to which the extract of the present invention can be added include, for example, various foods, beverages, gums, candies, tea, vitamin complexes, and functional foods. In addition, in the present invention, the food may contain special nutritional foods (eg, crude oil, spirits, etc.), meat products, fish products, tofu, jelly, noodles (eg, (Such as soy sauce, soybean paste, kochujang, mixed potatoes), sauces, confectionery (eg snacks), dairy products (eg fermented milk, cheese, etc.), other processed foods, kimchi, But are not limited to, beverages (such as fruit, vegetable beverages, beverages, fermented beverages, ice creams, etc.), natural seasonings (such as ramen soup), vitamin complexes, alcoholic beverages, Do not. The food, beverage or food additive may be prepared by a conventional production method.

In the present invention, the functional food refers to a food group which is imparted with added value to function and express the function of the food by using physical, biochemical, biotechnological techniques and the like, the regulation of the biological defense rhythm of the food composition, The functional food of the present invention is preferably a food which is processed so that the body control function for preventing or ameliorating the oral disease can be sufficiently expressed in the living body It means food. The functional food may include a food-acceptable food-aid additive, and may further comprise suitable carriers, excipients and diluents conventionally used in the production of functional foods.

In the present invention, beverage is a generic term for drinking or enjoying a taste, and is intended to include functional beverages. The beverage is not particularly limited as long as it contains the extract of Hwangbuk as an essential ingredient in an indicated ratio as an active ingredient, and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and Xylitol, sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above The ratio of the natural carbohydrate is generally about 1 to 20 g, preferably 5 to 12 g, per 100 ml of the composition of the present invention. In addition, the composition of the present invention can be applied to natural fruit juice, fruit juice drink, May be further contained.

In addition to the above-mentioned composition, the composition of the present invention can be used as a flavoring agent such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, coloring agents and intermediates (cheese, chocolate etc.), pectic acid and its salts, Salts, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated beverages and the like. These components can be used independently or in combination.

The functional beverage according to the present invention can be used to control the bio-defense rhythm of the beverage group or beverage composition to which the added value is imparted so that the function of the beverage acts on the specific purpose by physical, biochemical or biotechnological techniques, Means a beverage which has been designed so that the body control function related to restoration and the like is sufficiently expressed in the living body.

The functional beverage is not particularly limited to the other ingredients except that it contains the extract of the present invention as an essential ingredient in the indicated ratio, and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. Examples of such natural carbohydrates include monosaccharides such as disaccharides such as glucose and fructose such as maltose, sucrose and the like and polysaccharides such as dextrins, cyclodextrins and the like, and xylitol , Sorbitol, and erythritol. Natural flavors (tau martin, stevia extract (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above .

The present invention provides an oral hygiene composition for preventing or ameliorating an oral disease comprising an extract of mulberry as an active ingredient. The oral care composition of the present invention includes all kinds and formulations that can be used for oral hygiene. Non-limiting examples of the oral hygiene composition include toothpaste, mouthwash, oral spray, oral ointment, gum, and the like.

When the oral care composition of the present invention is a dentifrice, it may further comprise an abrasive, a binder, a moisturizer, a foaming agent, a sweetener, a whitening agent, or a flavoring agent, Examples of the abrasive include aluminum hydroxide, silicic anhydride, aluminum silicate, calcium hydroxide dibasic hydroxide and anhydrous calcium carbonate, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, magnesium phosphate, magnesium carbonate, calcium sulfate, Polymethyl methacrylate, and the like can be used alone or in combination. The content of the abrasive may be generally 20% by weight to 90% by weight based on the total composition, but is not limited by the content.

When the oral care composition is a paste-like composition, the viscous solution may contain at least one of polyvinyl alcohol, sodium polyacrylate, polyacrylic acid / polyacrylic acid, polyvinyl alcohol, polyacrylic acid / Maleic acid copolymer and synthetic polymer derivatives such as carboxyvinyl polymer, and inorganic-based binders such as silica and laponite may be used singly or in combination. The content of the viscous agent may be generally from 0.3% by weight to 5% by weight based on the total composition, but is not limited by the content.

In addition, the oral hygiene composition may further contain sorbitol, glycerin, ethylene glycol, propylene glycol, polyether glycol, polypropylene glycol or the like as a moisturizing agent in its preparation.

In addition, the oral hygiene composition may further include a fragrance or a sweetener. The sweetener may be sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, glycerin, sodium saccharin, stevioside, aspartame, and the flavoring may be peppermint, menthol, anethole, The sweetener or fragrance may be used alone or in combination of two or more thereof. The sweetener or flavoring agent may be selected from the group consisting of alginic acid, citric acid, citric acid, limonene, citronellol, alpha terpineol, salicylmethyl, cineol, linarol, ethyl linolol, vanillin, thymol, spearmint oil, Or may be used in combination.

In addition, the oral hygiene composition of the present invention may contain a surfactant or an additional effective ingredient, which is used as a foaming component, alone or in combination. The surfactant used as the foaming component may be any one selected from the group consisting of an anionic surfactant, a nonionic surfactant and a cationic surfactant.

When the oral care composition of the present invention is a dentifrice, the dentifrice composition of the present invention may be prepared by a conventional dentifrice manufacturing method, except that the dentifrice extract is contained as an active ingredient. When the dentifrice composition of the present invention is a mouthwash solution, And the oral extract can be mixed and formulated into a saline solution. Oral diseases can be prevented or treated by washing the mouth 2 to 10 times a day.

Further, when the oral care composition of the present invention is a tooth paste cream, it may further include a liquid containing water and a moisturizing agent, a gelling agent or a water-insoluble polish agent, a sweetener, a fragrance and the like.

In addition, when the oral care composition of the present invention is a mouthwash (cleaning agent), it may further comprise a toothpaste carrier, more specifically, a non-toxic alcohol.

The method for preparing a composition for treating or preventing an oral disease of the present invention can be produced according to a method conventionally prepared in the art for manufacturing the same.

In the present invention, the extract may be 0.001 to 10% by weight, preferably 0.005 to 5% by weight based on the total weight of the composition, more preferably 0.008 to 1% %. ≪ / RTI > If the extract is less than 0.001% by weight based on the total weight of the composition, it may be ineffective for oral diseases. If the extract is more than 10% by weight, it may be undesirable because the sensation of taste,

The composition for oral use of the present invention may further contain, as ingredients, a wetting agent, an abrasive, a pharmacological agent, a sweetening agent, a pH adjuster, a preservative, a binder, a flavoring agent, a foaming agent and the like in addition to the above- .

The wetting agent may be used alone or in combination of one or more selected from the group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycols and propylene glycol. The amount of the wetting agent is 1 to 70% by weight based on the total weight of the oral composition.

The abrasive may be one selected from the group consisting of precipitated silica, silica gel, zirconium silicate, calcium monohydrogenphosphate, anhydrous calcium hydrogenphosphate, hydrated alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate Etc. may be used. The amount of the abrasive to be used is generally 1 to 60% by weight based on the total weight of the oral composition. As a small amount of additives to be used, commonly used ingredients include sweeteners, pH adjusters, preservatives, coloring agents, and binders.

The active agent may be selected from the group consisting of sodium fluoride, sodium fluorophosphate, sodium fluoride, tin fluoride, chlorohexidine, allantoin chlorohydroxy aluminate, aminocaproic acid, zinc chloride, pyridoxine hydrochloride, tocopheryl acetate, Or more.

As the sweetening agent, saccharin, xylitol, erythritol, aspartame and the like can be used. The amount of the sweetener to be used is generally 0.05 to 2% by weight based on the total weight of the oral composition.

As the pH adjusting agent, sodium phosphate, disodium phosphate, citric acid, triethanolamine and the like can be used.

As the preservative, benzoic acid, methylparaben, propylparaben, sodium benzoate and the like can be used. As the fragrance, peppermint oil, spearmint oil, menthol and the like may be mixed and used. Other additives such as dextrinase may be used.

Carrageenan, xanthan gum, carboxymethylcellulose sodium, carboxyvinyl polymer, sodium alginate, and laponite may be used alone or in admixture of two or more.

As foaming agent, a copolymer of sodium lauryl sulfate, an anionic surfactant, polyoxyethylene polyoxypropylene (non-ionic surfactant), polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester and the like can be used .

Others may include residual water.

According to another embodiment of the present invention, there is provided an oral hygiene product comprising the composition. The composition for oral hygiene according to the present invention containing the extract of mulberry is an oral hygiene composition which can be generally included in products manufactured for oral health and is commercially available. The oral hygiene product to be applied is not limited. For example, the oral care products include, but are not limited to, toothpastes, oral sprays, oral ointments, mouth patches, and mouthwashes. The oral care product of the present invention may be in the form of a liquid, a solid, a suspension, a gel, and an aerosol, but is not limited thereto.

The composition containing the mildew extract of the present invention provides preventive, ameliorative or therapeutic effects of oral diseases.

The present invention provides a composition for preventing, ameliorating or treating oral diseases derived from natural materials, which has few side effects and is safe for the human body and can inhibit the growth of bacteria in the oral cavity.

It is possible to provide a composition which shows excellent dental caries, periodontal disease, prevention or improvement of bad breath, and is free of toxicity and excellent in stability.

Prevention and treatment of dental caries, and the like.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the embodiments described below. The embodiments of the present invention are provided by way of example to facilitate a specific understanding of the present invention.

<Preparation of mulberry extract>

The perilla extract of the present invention was prepared by the following method.

Wang cherry bark was sieved and immersed in a 95% ethanol solution and extracted at room temperature for 48 hours to obtain a mulberry extract.

<Experiment 1. Antibacterial effect test>

The antimicrobial activity test was carried out using the paper disk method to determine whether the antimicrobial activity was inhibited by using Gram positive Streptococcus mutans strains and Gram negative strains, Poppyromonas genus varis, which are representative bacteria of periodontal disease and periodontal disease. The bacterium was cultivated in the optimal culture conditions shown in Table 1 below, and cultured for 4 to 6 hours in the optimum medium of each microorganism. The turbidity of the culture was measured by Macfarland turbidity No. 2. 0.5 (1.5 x ^{10 8} ), and 0.1 ml was evenly smoothed. Safflower extract was inoculated on a sterilized paper disk (Whatman no. 5 paper, 8 mm diameter) at a concentration of 10 mg / disc and absorbed and dried for 1 hour before use. The size (mm diameter) of the growth inhibition rings was measured after 24-48 hours of incubation at the optimum temperature of each of the above bacteria.

Strain Optimum condition Gram staining Strain name Temperature badge characteristics Gram (+) Streptococcus mutans 37 ℃ BHI Facultative anaerobic Gram (-) Porphyromonas gingivalis 37 ℃ TSA Hemin Menadione medium Anaerobic

The results are shown in the following table.

Antimicrobial activity of oral extracts against oral pathogens

Growth inhibition diameter (mm) S.mutans P. gingivalis No treatment - (No inhibition) - (No inhibition) Hwaseum Extract Treatment 10.7 10.6

<Experiment 2. Inhibitory effect of gingival inflammation formation>

In order to compare the degree of inhibition of gingival inflammation formation, it is preferable to firstly dissolve sodium carboxymethylcellulose sodium, sodium laurylsulfate, glycerin, colloidal silicon dioxide, silica, sodium cocoyl sodium catecholate , Dodine, a sweetener, a fragrance, a coloring agent and the like were used to prepare a control toothpaste, and an experimental toothpaste containing 0.01% by weight of a mushroom extract was prepared.

Subjects were divided into 10 groups according to their gender, from 30 to 50 years of age. The subjects were divided into groups of 120 subjects. Clinical studies on the therapeutic effect of gingival inflammation were performed.

The subjects were divided into two groups: experimental group and control group. After training, they were instructed to use three times a day before sleeping after 2 hours' After 6 months and 6 months, oral examinations were performed to check gingival index. The gingival index was measured by inserting a periodontal probe into the gingival sulcus and burning around each tooth without applying any force. After 30 seconds, the gingival index was measured. And the results were obtained.

score Contents 0 point No bleeding state 1 point Normal bleeding state 2 points Hemorrhage 3 points Triangle Bleeding 4 points Gingival hemorrhage

Gingival inflammation inhibitory effect

group
time Control group Test group 0 weeks 1.05 1.04 1 week 1.62 1.05 1 month 2.08 1.12 3 months 2.50 1.14 6 months 2.72 1.16

<Experiment 3. Comparison of inhibition of silent phenomenon>

In order to compare the degree of suppression of the syringes, there can be mentioned, for example, carboxymethylcellulose sodium, sodium laurylsulfate, glycerin, colloidal silicon dioxide, silicas, sodium cocoyl sulfate, sodium cocoate, Control dentifrice was prepared using Dodicin, sweetener, aroma agent, coloring agent and the like, and an experimental dentifrice containing 0.01 wt% of extract of Hwangbuk was prepared.

The degree of suppression of the syringes of the compositions prepared above was compared and measured. In other words, the study subjects were 40 volunteers who agreed to participate in this experiment. Among the applicants, 20 were male and 20 were female, and the ages ranged from 20 to 50 years. The study subjects were not informed about the contents of the toothpaste, and the total test period was 2 weeks.

After the temperature stimulus was applied, the test was performed by measuring the response of the patient. Prior to the test, the hypersensitive areas of the hypersensitive teeth of each volunteer were checked in advance, and cold water of about 5 ° C was dropped on the acupressure of the teeth and dropped on a syringe. After the evaluation, each composition was used three times a day for 2 weeks After 2 weeks, cold water of about 5 ° C was dropped into the eyedropper. After the stimulation, the patient's response rating criteria were set as follows (0 points: no discomfort, 1 point: slightly uncomfortable, 3 points: sick). Statistical analysis was done by paired student-t test.

The scores for the temperature stimulation after 2 weeks are shown in Table 5 below.

Degree of inhibition

group
time Control group Experimental group 0 weeks 2.13 + 0.06 2.12 ± 0.12 2 weeks 2.13 ± 0.32 1.65 ± 0.16 p > 0.05 * p < 0.05

As can be seen in Table 5 above, the response to temperature stimulation was much less in the experimental group treated with the extract of mulberry. This indicates that the inhibitory effect of silane was excellent in the group administered with the extract of Hwang. The components contained in the extract of Hwangwoo extract of the present invention meet the calcium component contained in the saliva and form a coating film on the tooth surface, .

<Experiment 4. Experiment of removing bad breath>

Sodium carboxymethylcellulose sodium, sodium lauryl sulfate, glycerin, colloidal silicon dioxide, silicas, sodium cocoyl iodate, sodium dodecyne and sweetener, which are commonly used to make toothpastes for comparison of the degree of halitosis. , A perfume, a coloring agent and the like were used to make a control toothpaste, and an experimental toothpaste containing 0.01% by weight of a mushroom extract was prepared

Fifty men and women without dental caries were selected and cross-over test was performed for the beverage. The commercially available garlic powder was dispersed in water, allowed to stand for 24 hours, and diluted so that the measured value of the halimeter was 700 ppb or more. The diluted solution was used as a source of bad breath. After 30 minutes of gagging with 15 ml of garlic diluted solution, the degree of halitosis was measured with a half-meter after one minute, and then groomed for 30 seconds to 1 minute using a control group and an experimental group of toothpaste. After 1, 5, and 30 minutes of rinsing, the degree of halitosis was measured with a halimeter meter to measure the persistence of halitosis suppression. The results are shown in the following table.

Bad breath removal effect

group
time Control group Experimental group 1 minute 58.2% 93.9% 5 minutes 44.7% 85.1% 30 minutes 36.4% 79.3%

[meaning]

It was confirmed that the mulberry extract exhibited dental caries, prevention or improvement of periodontal disease, and removal of bad breath. In addition, the degree of irritation to the temperature stimulus was improved to give a mitigating effect of silane.

It is believed that the herbal extract of the present invention has a definite effect as a natural material contained in an oral composition to effectively maintain and improve oral health.

Claims (16)

An oral hygiene composition for preventing or ameliorating an oral disease comprising an extract of mulberry as an active ingredient. The method according to claim 1, wherein the extract is selected from the group consisting of water, distilled water, methanol, ethanol, propanol, isopropanol, butanol, acetone, ether, benzene, chloroform, ethyl acetate, methylene chloride, n-hexane, Wherein the composition is extracted with at least one solvent selected from the group consisting of ether and cyclohexane. 2. The oral care composition according to claim 1, wherein the mildew extract is extracted with water, ethanol, or a mixture thereof. The oral hygiene composition according to claim 1, wherein the extract is from 0.001 to 10% by weight based on the total weight of the pharmaceutical composition. The oral care composition according to claim 1, wherein the oral disease is at least one disease selected from the group consisting of halitosis, syringe, dental caries, periodontal disease, and oral mucosal ulcer. The oral care composition according to claim 5, wherein the oral disease is psoriasis. The oral care composition according to claim 5, wherein the periodontal disease is gingivitis and periodontitis. The oral care composition of claim 1, wherein the composition has an antibacterial effect in streptococcus or Porphyromonas . The method of claim 8, wherein the Streptococcus (streptococcus) in or wrapping as Pseudomonas (Porphyromonas) genus Streptococcus mutans (streptococcus mutans), Streptococcus sanggwi switch (streptococcus sanguis), Streptococcus sanggwi varnish (Streptococcus sanguinis), Streptococcus Salivarius species Thermophilus ( Streptococcus salivarius subsp. thermophils , and Porphyromonas &lt; RTI ID = 0.0 &gt; gingivalis , &lt; / RTI &gt; and the like. 10. The method of claim 9, wherein the Streptococcus (streptococcus) The genus Streptococcus is Tansu mu (streptococcus mutans),
Wherein the Porphyromonas genus is Porphyromonas gingivalis . &Lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt; The oral care composition according to claim 1, wherein the extract of mulberry forms a coating film on the surface of the tooth to thereby alleviate or ameliorate the symptom thereof. The pharmaceutical composition according to claim 1, wherein the oral care composition has one or more formulations selected from the group consisting of a toothpaste, a mouthwash, an oral spray, an oral ointment, a mouth patch, and gum. A food composition for preventing or ameliorating an oral disease comprising an extract of mulberry as an active ingredient. 14. The food composition according to claim 13, wherein the oral disease is at least one disease selected from the group consisting of halitosis, rhinorrhea, dental caries, periodontal disease, and oral mucosal ulcer. A pharmaceutical composition for preventing, ameliorating or treating oral diseases, comprising an extract of mulberry as an active ingredient. [Claim 16] The pharmaceutical composition according to claim 15, wherein the oral disease is at least one disease selected from the group consisting of halitosis, sialin, dental caries, periodontal disease, and oral mucosal ulcer.