KR20170094632A - Manufacturing method for hair loss prevention shampoos containing ginsenoside Rg2 - Google Patents

Abstract

The present invention relates to a method of preparing a shampoo for preventing hair loss comprising enhanced ginsenoside Rg2. According to the method of the present invention, pulverized red ginseng is continuously extracted 1-5 times at an extraction temperature of 20-100C for about 30 minutes to 5 hours with a mixed solvent of water, ethanol, and methanol in an amount 5-25 times the dry weight of the red ginseng by methods such as hot water extraction, cold extraction, reflux extraction, and ultrasonic extraction, and filtered using a filter paper; the filtrate is concentrated in a vacuum concentrator at 20-80C under reduced pressure; and the concentrate is dried by methods such as vacuum freeze drying, hot air drying, or spray drying to obtain dry red ginseng extract powder having enhanced Rg2. Further, the present invention provides a shampoo for preventing hair loss comprising enhanced ginsenoside Rg2 as an effective component, which is prepared by mixing 65-75 wt% of a composition with 25-35 wt% of a known shampoo composition, wherein the composition comprises: 1.0-1.5 wt% of the obtained red ginseng extract; 1.0-2.0 wt% of aroma oils; 1-2 wt% of wheat protein; 1.0-1.5 wt% of lecithin; 0.5-1.0 wt% of amino acids; 30-35 wt% of sodium bicarbonate; and 1.0-1.5 wt% of sodium chloride.

Description

[0001] The present invention relates to a method for manufacturing hair loss preventing shampoos containing RG2,

The present invention relates to a shampoo for preventing hair loss, which comprises ginsenoside (RG2) extracted with an extraction solvent selected from lower alcohols, polar solvents, non-polar solvents and mixed solvents thereof, ≪ / RTI >

Ginsenoside (hereinafter referred to as "RG2") is a kind of saponin, and the saponin of ginseng is usually called "ginsenoside", which is a glycoside isolated from ginseng glyco-side). It is usually named ginsenoside-Rx and abbreviated as G-Rx.

Here, "R" stands for Radix or Root. In addition, "x" is the name (in the order of o, a, b, c, d, e, f, g, h, etc.) from bottom to top according to the distance traveled by the spot (Rf value) It is attached.

Up to now, 38 kinds of ginsenosides have been isolated from Korean ginseng (red ginseng and white ginseng) and its chemical structure has been revealed. However, when red ginseng is cooked at a higher temperature (120 ° C) than conventional (about 98 ° C), there is another type of ginsenoside in addition to red ginseng-specific ginsenoside.

Ginseng saponin has various effects on controlling the body function by affecting the central nervous system, endocrine system, immune system, metabolism system and the like. More than 30 kinds of ginsenosides have been identified from Korean ginseng (including red ginseng) so far, and the pharmacological action of each ginsenoside has been revealed.

Among the ginsenoside components, Rg1, Rb1, and Rg3 are the key ingredients for improving immunity and restoring fatigue.

Rg1 is involved in central nerve stimulation, antipyretic action, fatigue recovery, memory, learning function improvement, DNA · RNA synthesis promoting action, and prasmin activating action, and Rb1 is a central nerve inhibitory action, hypnotic action, Rg3 is a hormone that acts to stimulate the secretion of serum proteins, stimulates the production of serum proteins, inhibits triglycerides, promotes insulin-like synthesis, promotes cholesterol biosynthesis, activates plasmin, promotes RNA synthesis, and promotes hormone secretion. And inhibits cancer cell metastasis.

As known, red ginseng is prepared by boiling and drying the ginseng. During the treatment process, the secondary component changes and the ginsenosides Rs, Rg1, Rg2, and Rg2, which are unique to ginseng and white ginseng Rh1 etc.) and the like are produced, and the content of the active ingredient such as antioxidant activity is increased. Of the ginsenosides contained in red ginseng, Rh1 has cytotoxic, antiallergic and anti-inflammatory activities against the growth of various cancer cells. In addition, Rg2 is known to have anti-cancer, anticonvulsant disease, anti-aging, and immunity-enhancing functions.

KR 10-2001-0016979 A (published on 21.01.06.01) KR 10-2002-0076834 A (* disclosed on October 11, 2002)

The present invention provides a method for manufacturing a shampoo which can maximize skin activity of scalp cells by resolving the strong antioxidative action of ginsenoside Rg2 of red ginseng, relieving stress of cells, helping the health of scalp and hair, and preventing hair loss do.

The red ginseng saponin extract according to the present invention is prepared by subjecting ground red ginseng to a hot water extraction and a cold extraction at a extraction temperature of 20 to 100 ° C for about 30 minutes to 5 hours in a mixed solvent of 5 to 25 times the dry weight of water and ethanol and methanol , Followed by filtration with a filter paper. The filtrate is concentrated under reduced pressure at 20 to 80 ° C in a vacuum concentrator, and the concentrate is subjected to vacuum lyophilization or hot air drying or spraying method , 1.0 to 2.0% by weight of aroma oil, 1 to 2% by weight of wheat protein, 1.0 to 1.5% by weight of lecithin, and the like. From 65 to 75% by weight of a composition consisting of from 0.5 to 1.0% by weight of amino acids, from 30 to 35% by weight of sodium bicarbonate, and from 1.0 to 1.5% by weight of sodium chloride; 25 to 35% by weight of a known shampoo composition are mixed to prepare a shampoo enhanced with ginsenoside Rg2.

According to the method for producing a cosmetic composition of the present invention, it is possible to provide a shampoo which contains red ginseng saponin extract to prevent hair loss by antioxidative action for anti-aging. have.

Hereinafter, the present invention will be described in more detail by way of examples. It is to be understood by those skilled in the art that these examples are for illustrative purposes only and that the scope of the present invention is not construed as being limited by these examples.

Example 1. Hot water extraction using water

1 kg of red ginseng powder, which had been ground to a particle size of 0.05 mm to 2 mm, was added to 10 L of water and refluxed for extraction at 60 to 65 ° C for 5 hours. The filtrate was separated Respectively. The separated filtrate was concentrated under reduced pressure at 55 ~ 65 ℃ and then lyophilized to obtain Rg2 enhanced red ginseng extract.

Although the particle size of the red ginseng powder is not limited in the above process, when the size of the particles of the ground ginseng powder exceeds the upper limit value, that is, when the particle size exceeds 2 mm, even when the heat treatment is applied, Of red ginseng powder containing ginsenoside Rg2 may not be obtained.

Example 2. Hot water extraction using a water-ethanol mixed solvent

1 kg of the red ginseng powder which had been pulverized so that the particle size of the red ginseng powder produced in the well-known manufacturing process was 0.05 mm to 2 mm was mixed with 10 L of 30% (v / v), 50% (v / v), 70% ) Ethanol solution, reflux-extraction was performed at 60 to 65 ° C for 5 hours while stirring well, and the filtrate was separated by filtration. The separated filtrate was concentrated under reduced pressure at 55 to 65 ° C and then lyophilized to obtain red ginseng extract having enhanced Rg2.

Example 3: Extraction with a mixed solvent of water and methanol

1 kg of pulverized red ginseng powder was added to 10 L of 80% (v / v) methanol aqueous solution so that the particle size of the red ginseng powder prepared in the well-known manufacturing process was 0.05 mm to 2 mm, and the mixture was immersed and extracted at room temperature for 24 hours Next, the filtrate was separated by filtration. This procedure was repeated twice. The separated filtrate was concentrated under reduced pressure at 55 to 65 ° C and then lyophilized to obtain Rg2-enriched red ginseng extract.

Example  4. Preparation of ginsenoside mixed shampoo (1)

1.0 to 2.0 wt% of red ginseng extract, 1.0 to 2.0 wt% of aroma oil, 1 to 2 wt% of whit protein, 1.0 to 1.5 wt% of lecithin, 0.5 to 1.0 wt% of amino acid, 30 to 30 wt% of sodium bicarbonate, 65 to 75% by weight of a composition consisting of 35% by weight of sodium chloride and 1.0 to 1.5% by weight of sodium chloride; 25 to 35% by weight of a known shampoo composition was mixed to prepare a shampoo for prevention of hair loss using the reinforced Rg2 as an active ingredient

Example  5. Preparation of ginsenoside mixed shampoo (2)

1.0 to 1.5 wt% of ginseng saponin, 0.5 to 1.0 wt% of amino acid, 30 to 35 wt% of sodium bicarbonate, 1.0 to 1.5 wt% of sodium chloride, 1.0 to 2.0 wt% of aroma oil, 1 to 2 wt% 70% by weight of the composition (A) and 30% by weight of a known shampoo composition were mixed to prepare a shampoo reinforced with ginsenoside Rg2.

As the extraction solvent, it is preferable to use the above-mentioned water, a lower alcohol such as methanol, ethanol and butanol, or a mixed solvent thereof, but 1-pentanol (1-pentanol), 2-butoxyethanol (2-butoxyethanol) , Polar solvents such as 1-propanol, 2-propanol, ethylene glycol, acetic acid, DMFO and DMSO, acetone, acetonitrile Nitrate), ethyl actate, methyl acetate, fluoroalkanes, pentanes, hexane, 2,2,4-trimethylpentane, 2,2,4-trimethyl 1-pentene (1-pentene), 1-chlorobutane (1-chlorobutane), 1-chloropentane (diisobutylene) (1-chloropentane), o-xylene (o-xylene), diisopropyl ether (diisopropyl ether), 2-chloropropane (2-chloropropane) diethyl ether (diethyl sulfide), chloroform (chloroform), dichloromethane (dichloromethane), 1,2-propanediol, and the like. Rg2-enriched red ginseng extract is prepared by using a nonpolar solvent such as dichloroethane (1,2-dichloroethane), dimethyl sulfoxide (dimethylsulfoxide), aniline (aniline), diethylamine (diethylamine), ether, carbon tetrachloride, Fractions may be obtained.

Rg2, which is an extract of red ginseng, acts through the pores of the scalp to promote the activity of the skin. When the amount is less than 1.0% by weight, it is difficult to obtain the desired effect. When the amount is more than 2% by weight, The increase in the effect is not great and the production cost is increased. Therefore, it is preferable to mix the components within the above-mentioned range.

Also, it may be selected from aroma oil, cypress oil, grape flute oil, lavender oil, rosemary oil, tea trioyl, and either one of these oils may be selected singly or two or more thereof may be mixed.

These aroma oils are used to supply the nutrients to the epidermal tissues of the scalp and to provide the effect of aroma telepathy by the ingredients contained in the oil itself. It is not necessary to use excessive amount of the aroma oil. In the case of using a small amount of the aroma oil, It is suitable to use within the above-mentioned range.

The use of more than 2% by weight of maltodextrin may cause malodour due to the decomposition of residual protein. When the maltodextrin is used in an amount of less than 1% by weight, The protein supply effect is reduced.

Lecithin is a dispersant that mixes an oil-soluble ingredient and a water-soluble ingredient. If less than 1.0% by weight is added, homogenization of the composition can not be achieved. If the ingredient is added in an amount exceeding 1.5% by weight, Lt; / RTI >

In order to observe the activity of the present invention, in order to observe the antioxidative action for antioxidation, it is known that the effect of inhibiting tyrosinase activity, melanin biosynthesis in relation to melanin action for skin freezing effect, The effect of inhibition, the effect of removing melanin, and the like were observed and observed. As a result, it was found that the above effect was significant.

Therefore, the red ginseng extract of the present invention can be used in various kinds of cosmetics.

One of the causes of hair loss is the lack of collagen (collagen, elastin) in the skin. Collagen is the main protein that constitutes the skin dermis and plays a role in maintaining skin structure and elasticity. Collagen and elastin are degraded due to environmental factors and aging, and their degradation is increased, and the structure of the skin polymer network is damaged. As a result, elasticity of the skin is reduced and restoration ability is lowered, thereby causing hair loss. Conventional wrinkle-improving cosmetics are predominantly comprised of retinol components that promote cell proliferation of epithelial cells and endothelial cells and collagen synthesis, which is a component of the dermis. This is because collagen promotes cell proliferation of fibroblasts, promotes angiogenesis of skin damaged area and induces secretion of other regeneration promoting factors, promotes synthesis of fibronectin, Because it plays a key role in

According to the manufacturing method of the present invention, the red ginseng extract having enhanced Rg2 is also closely related to the regeneration of skin tissue, which is similar to the collagen, and thus can be usefully used as a mixture of shampoo which can prevent hair loss.

Claims (1)

The pulverized red ginseng is subjected to a hot water extraction, a cold extraction, a reflux cooling extraction or an ultrasonic extraction method in a mixed solvent of 5 to 25 times the dry weight of water, ethanol and methanol at an extraction temperature of 20 to 100 ° C for about 30 minutes to 5 hours The filtrate is concentrated under reduced pressure at 20 to 80 ° C in a vacuum concentrator, and then the concentrate is subjected to vacuum freeze drying or hot air drying or spray drying method , 1.0 to 2.0% by weight of aroma oil, 1 to 2% by weight of wheat protein, 1.0 to 1.5% by weight of lecithin, 0.5% by weight of amino acid of 0.5% by weight of red ginseng extract obtained by strengthening Rg2, 65 to 75% by weight of a composition comprising 1.0 to 1.0% by weight of sodium bicarbonate, 30 to 35% by weight of sodium bicarbonate, and 1.0 to 1.5% by weight of sodium chloride; And 25 to 35% by weight of a known shampoo composition are mixed to produce a shampoo reinforced with ginsenoside Rg2.