KR20170029140A - A composition for improving, preventing and treating angiogenesis-related disease comprising rice-wine - Google Patents
A composition for improving, preventing and treating angiogenesis-related disease comprising rice-wine Download PDFInfo
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- KR20170029140A KR20170029140A KR1020150126095A KR20150126095A KR20170029140A KR 20170029140 A KR20170029140 A KR 20170029140A KR 1020150126095 A KR1020150126095 A KR 1020150126095A KR 20150126095 A KR20150126095 A KR 20150126095A KR 20170029140 A KR20170029140 A KR 20170029140A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12G—WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES; PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H
- C12G3/00—Preparation of other alcoholic beverages
- C12G3/02—Preparation of other alcoholic beverages by fermentation
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/10—Drying, dehydrating
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Mycology (AREA)
- Organic Chemistry (AREA)
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- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
The present invention relates to a composition capable of preventing or treating diseases caused by angiogenesis by inhibiting angiogenesis using rice wine.
Our traditional Korean rice wine is a kind of brewed wine that has been widely used for its own production and is an alcoholic drink made by combining sugar and fermentation process.
Drinking alcohol with high alcoholic strength makes us drunk soon and gives us a lot of burden. However, our traditional wine makgeolli has relatively low alcohol content and does not burden us as a fermented food using cereals. In addition, the makgeolli produced in the brewery contains about 8% ethanol and contains a large amount of protein, saccharides, riboflavin and various nutrients.
In addition, volatile flavor components are generated by fermentation of alcohol by the microorganisms such as sugar, amino acid, organic acid, etc. and yeast and lactic acid bacteria produced by decomposition of the raw material component due to the enzyme action by the microorganism in the yeast after immersion, And the quality is harmonized with.
The rice wine contains a substance called farnesol, which induces apoptosis through its anticancer ability, such as an increase in killing protein in cancer cells ( Food Chem . 152, 624-632; Int . Oncol ., 30, 905-918).
The parnesol is contained in 150 to 500 ppb, and in order to take anticancer effect by consuming makkolli, 10 or more should be consumed per 1 L, so liver damage may be caused instead of suppressing cancer.
Angiogenesis, on the other hand, is the process by which new blood vessels are formed from existing blood vessels and plays a very important role in normal human defense and physiological phenomena such as wound healing and inflammatory reaction and early development. Such angiogenesis is a process in which blood vessels are reconstituted by the decomposition of blood vessel basement membrane by proteolytic enzymes, migration of vascular endothelial cells forming vascular walls, formation of vascular endothelial cells by proliferation and endothelial cell differentiation, and formation of new capillary vessels ≪ / RTI > and the like.
In addition, the process of angiogenesis is strictly controlled by various negative and positive regulators ( Int . Rev. Exp . Patho . , 16, 207-248 , 1976). If such angiogenesis is not regulated normally, Rheumatoid arthritis, and diabetic retinopathy. In particular, abnormal angiogenesis is known to play a very important role in tumor growth and metastasis. First, it plays a role in supplying nutrients and oxygen necessary for tumor growth and proliferation. Second, The blood vessels provide the opportunity for the metastatic cancer cells to enter the blood circulation system so that the cancer cells spread to the whole body and become metastasized.
Specifically, a cancer cell produces a new blood vessel for survival and secretes an inducing factor. Unlike normal cells, cancer cells continue to grow in characteristics, but the stacked cells form a single tumor. As a result, the cells located inside the tumor become unable to receive nutrients or oxygen from the blood, so that the cells increase the expression of genes for angiogenesis and are supplied with nutrients through the newly formed blood vessels, It grows uncontrollably and continuously. Therefore, inhibition of angiogenesis is one of the important ways to prevent the growth of cancer cells.
Therefore, there is a need for a method using makkolli which is made only of natural substances for inhibiting angiogenesis.
It is an object of the present invention to provide a food composition capable of improving, preventing or treating a disease caused by angiogenesis by inhibiting angiogenesis using rice wine.
Another object of the present invention is to provide a pharmaceutical composition capable of improving, preventing or treating a disease caused by angiogenesis by inhibiting angiogenesis using rice wine.
To achieve the above object, the present invention provides a food composition for improving, preventing or treating diseases caused by angiogenesis, which comprises a makkolli dried powder as an active ingredient.
The makkolli dried powder may be a makgeolli precipitate powder.
The makgeolli precipitate may be a precipitate separated from the liquid phase of the alcohol component by subjecting the makgeolli to settling, evaporation, centrifugation or filtration.
The drying may be performed by lyophilization, cold air drying or natural drying.
The dried rice wine may be used at a concentration of 10 to 1500 占 퐂 / ml, particularly 100 to 1000 占 퐂 / ml when the rice wine is a precipitate powder.
According to another aspect of the present invention, there is provided a pharmaceutical composition for improving, preventing or treating diseases caused by angiogenesis, which comprises a makkolli dried powder as an active ingredient.
The makkolli dried powder may be a makgeolli precipitate powder, or a mixture powder in which a liquid phase and a precipitate are mixed.
The dried rice wine may be used at a concentration of 10 to 1500 占 퐂 / ml.
The composition for improving, preventing or treating diseases caused by angiogenesis of the present invention shows excellent angiogenesis inhibitory effect even when consuming a small amount of rice wine, and can be ingested in the form of food because there is no toxicity. In particular, the composition of the present invention is useful for the treatment of ocular diseases caused by angiogenesis, such as diabetic retinopathy, retinopathy of prematurity, neovascular glaucoma, corneal diseases caused by neovascularization, degeneration, dense patches, pterygium, retinal degeneration and granular conjunctivitis Prevention or treatment.
The present invention relates to a composition capable of improving, preventing or treating a disease that can be caused by angiogenesis by inhibiting angiogenesis using rice wine.
Hereinafter, the present invention will be described in detail.
The composition for improving, preventing or treating diseases caused by angiogenesis of the present invention contains makkolli dried powder as an active ingredient. The makkolli dried powder is a mixture powder or a makgeolli precipitate powder, preferably a makgeolli precipitate powder, in which a makkolli liquid phase and a precipitate are mixed.
The makkolli sediment refers to a substance which is separated from the liquid phase of the alcohol component by settling, evaporating, centrifuging or filtering the makkolli.
The 'makgeolli' of the present invention is not particularly limited as long as it contains a fermentation broth fermented by inoculating rice or wheat into yeast and yeast.
The makkolli is a liquid phase containing an alcohol component and a natural carbonic acid component; And precipitates containing yeast, enzymes, protein organic matter, minerals and the like. Therefore, a mixture in which a liquid phase and a precipitate are mixed or a precipitate in which a liquid phase is removed can be used as needed.
The drying method to be used for pulverizing the mixture or the precipitate of Makkolli which is a mixture of the Makkolli liquid phase and the precipitate is freeze drying, cold air drying or natural drying. However, freeze drying method Is preferably used.
As used herein, the term " comprising as an active ingredient " is meant to include an amount sufficient to achieve the efficacy or activity of the mungbean dry powder. For example, the macheol dry powder is used at a concentration of 10 to 1500 μg / ml, preferably 100 to 1000 μg / ml. Since the makkolli dried powder has no adverse effect on the human body even when it is administered in an excessive amount as a natural product, the quantitative upper limit of the dried makkolin powder contained in the composition of the present invention can be selected by a person skilled in the art within a suitable range.
The pharmaceutical composition of the present invention can be prepared by using pharmaceutically acceptable and physiologically acceptable adjuvants in addition to the above-mentioned active ingredients. Examples of the adjuvants include excipients, disintegrants, sweeteners, binders, coating agents, swelling agents, lubricants, A lubricant or a flavoring agent can be used.
The pharmaceutical composition may be formulated into a pharmaceutical composition containing at least one pharmaceutically acceptable carrier in addition to the above-described active ingredients for administration.
The pharmaceutical composition may be in the form of granules, powders, tablets, coated tablets, capsules, suppositories, liquids, syrups, juices, suspensions, emulsions, drops or injectable solutions. For example, for formulation into tablets or capsules, the active ingredient may be combined with an oral, non-toxic pharmaceutically acceptable inert carrier such as ethanol, glycerol, water, and the like. Also, if desired or necessary, suitable binders, lubricants, disintegrants and coloring agents may also be included as a mixture. Suitable binders include, but are not limited to, natural sugars such as starch, gelatin, glucose or beta-lactose, natural and synthetic gums such as corn sweeteners, acacia, tracker candles or sodium oleate, sodium stearate, magnesium stearate, sodium Benzoate, sodium acetate, sodium chloride, and the like. Disintegrants include, but are not limited to, starch, methyl cellulose, agar, bentonite, xanthan gum and the like.
Acceptable pharmaceutical carriers for compositions that are formulated into a liquid solution include sterile water and sterile water suitable for the living body such as saline, sterile water, Ringer's solution, buffered saline, albumin injection solution, dextrose solution, maltodextrin solution, glycerol, One or more of these components may be mixed and used. If necessary, other conventional additives such as an antioxidant, a buffer, and a bacteriostatic agent may be added. In addition, diluents, dispersants, surfactants, binders, and lubricants may be additionally added to formulate into injectable solutions, pills, capsules, granules or tablets such as aqueous solutions, suspensions, emulsions and the like.
Further, it can be suitably formulated according to each disease or ingredient, using the method disclosed in Remington's Pharmaceutical Science, Mack Publishing Company, Easton PA as an appropriate method in the field.
The pharmaceutical composition of the present invention can be administered orally or parenterally. In the case of parenteral administration, the composition can be administered by intravenous injection, subcutaneous injection, muscle injection, intraperitoneal injection, transdermal administration, etc., .
The appropriate dosage of the pharmaceutical composition of the present invention varies depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, food, administration time, administration route, excretion rate and responsiveness of the patient, Usually, a skilled physician can readily determine and prescribe dosages effective for the desired treatment or prophylaxis. According to a preferred embodiment of the present invention, the daily dosage of the pharmaceutical composition of the present invention is 0.001-10 g / kg.
The pharmaceutical composition of the present invention may be formulated into a unit dose form by formulating it with a pharmaceutically acceptable carrier and / or excipient according to a method which can be easily carried out by a person skilled in the art to which the present invention belongs Or by intrusion into a multi-dose container. The formulations may be in the form of solutions, suspensions or emulsions in oils or aqueous media, or in the form of excipients, powders, granules, tablets or capsules, and may additionally contain dispersing or stabilizing agents.
Further, the present invention provides a food composition for improving, preventing or treating diseases caused by angiogenesis, which comprises a makkolli dried powder as an active ingredient.
The food composition according to the present invention can be formulated in the same manner as the above pharmaceutical composition and used as a functional food or added to various foods. Foods to which the composition of the present invention can be added include, for example, beverages, alcoholic beverages, confectioneries, diet bars, dairy products, meat, chocolates, pizza, ram noodles, other noodles, gums, ice cream, .
The food composition of the present invention may contain not only the macheled dry powder as an active ingredient but also components that are ordinarily added at the time of food production, for example, proteins, carbohydrates, fats, nutrients, flavoring agents and flavoring agents . Examples of the above-mentioned carbohydrates are monosaccharides such as glucose, fructose, and the like; Disaccharides such as maltose, sucrose, oligosaccharides and the like; And polysaccharides such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavorings such as tau martin and stevia extract (e.g., rebaudioside A and glycyrrhizin) and synthetic flavorings (saccharine, aspartame, etc.) can be used as flavorings. For example, when the food composition of the present invention is prepared from a drink and a beverage, it may further contain citric acid, liquid fructose, sugar, glucose, acetic acid, malic acid, fruit juice, .
The present invention provides a health functional food comprising a food composition for improving, preventing, or treating diseases caused by angiogenesis, which comprises the above-described macheled dry powder as an active ingredient. Health functional foods are foods made by adding makkolli dried powder to food materials such as beverages, tea, spices, gum, confectionary, or by encapsulation, powdering, suspension, etc., However, unlike general medicine, there is an advantage that there is no side effect that can occur when a food is used as a raw material and a drug is taken for a long time. The health functional food of the present invention thus obtained is very useful because it can be ingested routinely. The added amount of the mungbean dry powder in such a health functional food can not be uniformly determined depending on the kind of the health functional food to which it is added but may be added within a range that does not deteriorate the original taste of the food, 0.01 to 50% by weight, preferably 0.1 to 20% by weight. In the case of health functional foods in the form of pills, granules, tablets or capsules, they may be added usually in the range of 0.1 to 100% by weight, preferably 0.5 to 80% by weight. In one embodiment, the health functional food of the present invention may be in the form of a pill, tablet, capsule or beverage.
The present invention also provides the use of the dried rice wine for the preparation of medicines or foods for improving, preventing or treating diseases caused by angiogenesis. As described above, the makkolli dried powder can be used for the purpose of improving, preventing or treating diseases caused by angiogenesis.
The present invention also provides a method of improving, preventing or treating a disease caused by angiogenesis, comprising administering to a mammal an effective amount of a mungbean dry powder.
The term "mammal " as used herein refers to a mammal that is the subject of treatment, observation or experimentation, preferably a human.
As used herein, the term "effective amount" refers to the amount of active ingredient or pharmaceutical composition that elicits a biological or medical response in a tissue system, animal, or human, as contemplated by a researcher, veterinarian, physician or other clinician, ≪ / RTI > inducing a reduction of the symptoms of the disease or disorder. It will be apparent to those skilled in the art that the effective amount and the administration frequency of the active ingredient of the present invention will vary depending on the desired effect. Thus, the optimal dosage to be administered can be readily determined by those skilled in the art and will vary with the nature of the disease, the severity of the disease, the amount of active and other ingredients contained in the composition, the type of formulation, and the age, The age, body weight, sex, diet, time of administration, route of administration and fraction of the composition, duration of treatment, concurrent medication, and the like. In the prevention, treatment, or improvement of the present invention, it is preferable to administer the macheled dry powder at a dose of 0.001 g / kg to 10 g / kg once or several times a day for an adult.
The composition comprising the makkolli dried powder as an active ingredient in the treatment method of the present invention can be administered orally or rectally via the oral, rectal, intravenous, intraarterial, intraperitoneal, intramuscular, intrasternal, transdermal, topical, ≪ / RTI >
It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.
Production Example 1. Manufacture of Makkoli
After the first fermentation at 25 ° C for 2 days, 30 parts by weight of yeast, 0.05 part by weight of dry yeast and 200 parts by weight of water were added to 100 parts by weight of steamed rice, 200 parts by weight of steamed rice and 400 parts by weight of water were added, And fermented for two days to prepare rice wine.
Example 1. Raw Makkoli solution
The makgeolli mixed with the liquid phase prepared in Preparation Example 1 and the precipitate in a weight ratio of 1: 0.5 was lyophilized to prepare an undiluted solution of Makgeolli.
Example 2. Makkolli sediment _ Removal of alcohol component
The liquid of the makgeolli prepared in Preparation Example 1 was evaporated with a rotary evaporator (Labora 4000, Heidolph Instruments Inc., Schwabach, Germany) to obtain only a precipitate, and the precipitate was freeze-dried to prepare a makgeolli precipitate powder.
Comparative Example 1. Makkoli liquid phase _ Removal of sediment
The makkolli produced in Preparation Example 1 was filtered to obtain only a liquid phase, followed by lyophilization to prepare a rice wine liquid powder. At this time, when the volume decreased by more than 95% with respect to the volume before lyophilization, the freeze-drying was stopped to obtain a rice wine liquid powder.
<Test Example>
DMSO was used as a control, and the powders prepared in Examples and Comparative Examples were suspended in distilled water and filtered.
Test Example 1. Measurement of cell viability
10 [mu] l of HUVECs (human vascular endothelial cell, American Type Culture Collection (Manassas, VA, USA)) was used to induce neovascularization and the powders of the Examples and Comparative Examples were treated in a concentration- The cell death tendency was measured by WST-1 assay.
As shown in Table 1, the powders prepared according to Examples 1 and 2 of the present invention and the powder of Comparative Example 1 were found to have low cytotoxicity due to their excellent cell viability.
On the other hand, the control group using DMSO showed low cell viability.
Test Example 2. Assessment of angiogenesis inhibitory efficacy
Induced angiogenesis by culturing in a matrigel (CHEMICON, Billerica, MA, USA) containing angiogenesis inducing substances (FGF, VEGF, TGF-beta, etc.) using vascular endothelial cells (HUVEC) A microscope is used to analyze whether the formation of the new blood vessel occurs. Then, in order to investigate the effect of the powders prepared in Examples and Comparative Examples on the angiogenesis, cells were treated with each concentration to examine the inhibitory ability of angiogenesis. Neovascularization was observed using a phase contrast microscope (Olympus, Tokyo, Japan) and digital imaging.
As shown in Tables 2 to 5, the powders of Examples 1 and 2 of the present invention were confirmed to shorten the length of the induced new blood vessels or inhibit the newly formed blood vessels themselves by decomposing. In particular, it was confirmed that the powder of Example 2 further inhibited the neovascularization.
On the other hand, it was confirmed that the control and the powder of Comparative Example 1 hardly inhibited induced angiogenesis.
Test Example 3. Assessment of angiogenesis inhibitory efficacy _ Measurement of blood vessel length
Relative angiogenesis (length) values were expressed as percent values using a Pro-plus 6.0 program based on microscopic photographs.
The reduced length of the neovasculature was expressed in% based on untreated.
As shown in Table 6 above, it was confirmed that the length of the new blood vessels was reduced in a concentration-dependent manner in the powders prepared according to Examples 1 and 2 of the present invention. Example 1 showed that the length of neovascularization was reduced to 10.5% when 1,300 / / ml was used and that the length was no longer decreased even when the concentration was increased.
On the other hand, it was confirmed that the control and the powder of Comparative Example 1 had almost no reduction in angiogenesis inhibition because the length of the neovascularization was not reduced.
Hereinafter, formulation examples of the composition containing the powder of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.
Preparation Example 1. Preparation of powder
500 mg of the makkolli precipitate powder obtained in Example 2
Lactose 100 mg
Talc 10 mg
The above components are mixed and filled in airtight bags to prepare powders.
Formulation Example 2. Preparation of tablets
300 mg of the makgeolli precipitate powder obtained in Example 2
Corn starch 100 mg
Lactose 100 mg
Magnesium stearate 2 mg
After mixing the above components, tablets are prepared by tableting according to the usual preparation method of tablets.
Formulation Example 3. Preparation of capsules
200 mg of the makgeolli precipitate powder obtained in Example 2
Crystalline cellulose 3 mg
Lactose 14.8 mg
Magnesium stearate 0.2 mg
The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.
Formulation Example 4. Preparation of injection
600 mg of the makgeolli precipitate powder obtained in Example 2
180 mg mannitol
Sterile sterilized water for injection 2974 mg
Na 2 HPO 4, 12H 2 O 26 mg
It is prepared by the above-mentioned component content per ampoule according to the usual injection preparation method.
Formulation Example 5. Preparation of a liquid preparation
4 g of the makgeolli precipitate powder obtained in Example 2
10 g per isomer
5 g mannitol
Purified water quantity
Each component was added and dissolved in purified water according to the usual liquid preparation method, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed, and purified water was added thereto. The whole was adjusted to 100g by adding purified water, To prepare a liquid agent.
Preparation Example 6 Preparation of Granules
1,000 mg of the makkolli precipitate powder obtained in Example 2
Vitamin mixture quantity
Vitamin A Acetate 70
Vitamin E 1.0 mg
Vitamin B1 0.13 mg
0.15 mg of vitamin B2
Vitamin B6 0.5 mg
Vitamin B12 0.2
Vitamin C 10 mg
Biotin 10
Nicotinic acid amide 1.7 mg
Folic Acid 50
Calcium pantothenate 0.5 mg
Mineral mixture quantity
1.75 mg of ferrous sulfate
0.82 mg of zinc oxide
Magnesium carbonate 25.3 mg
Potassium monophosphate 15 mg
Secondary calcium phosphate 55 mg
Potassium citrate 90 mg
Calcium carbonate 100 mg
Magnesium chloride 24.8 mg
The composition ratio of the above-mentioned vitamins and minerals is comparatively comparatively mixed with the granules according to the preferred embodiment. However, the blending ratio may be arbitrarily changed, and the above components are mixed according to the ordinary granule preparation method, Can be prepared and used in the manufacture of a health functional food composition according to a conventional method.
Formulation example 7. Manufacture of functional beverages
1,000 mg of the makkolli precipitate powder obtained in Example 2
Citric acid 1,000 mg
100 g of oligosaccharide
Plum concentrate 2 g
Taurine 1 g
Purified water was added to the flask to obtain a total of 900 mL
The above components were mixed according to a conventional health drink manufacturing method, and the mixture was stirred and heated at 85 DEG C for about 1 hour. The solution thus prepared was filtered and sterilized in a sterilized 2 L container, It is used in the production of the functional beverage composition of the invention.
Although the composition ratio is a mixture of the components suitable for the preferred beverage as a preferred embodiment, the blending ratio may be arbitrarily varied according to the regional and national preferences such as the demand level, the demanding country, and the intended use.
Claims (10)
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| KR101159260B1 (en) | 2009-11-06 | 2012-06-25 | 농업회사법인주식회사 청산녹수 | manufacturing method of enzymatic degradation products of wild mulberry leaves and manufacturing method of rice wine using the same |
| KR101456182B1 (en) | 2012-11-06 | 2014-10-31 | 한국 한의학 연구원 | Pharmaceutical composition and functional food for prevention or treatment of angiogenesis-related diseases comprising Ilex integra extraction |
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| KR101159260B1 (en) | 2009-11-06 | 2012-06-25 | 농업회사법인주식회사 청산녹수 | manufacturing method of enzymatic degradation products of wild mulberry leaves and manufacturing method of rice wine using the same |
| KR101456182B1 (en) | 2012-11-06 | 2014-10-31 | 한국 한의학 연구원 | Pharmaceutical composition and functional food for prevention or treatment of angiogenesis-related diseases comprising Ilex integra extraction |
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