KR20170000609A

KR20170000609A - Method for preparing composition for promoting hair growth

Info

Publication number: KR20170000609A
Application number: KR1020150089744A
Authority: KR
Inventors: 이재욱
Original assignee: 이재욱
Priority date: 2015-06-24
Filing date: 2015-06-24
Publication date: 2017-01-03

Abstract

The present invention relates to a method for producing a hair growth promoting composition and a hair growth promoting composition prepared therefrom. More particularly, the present invention relates to a hair growth promoting composition for the production of hair growth promoting compositions for black hairy bean, hansuccho, hassuo, beer yeast, mulberry leaf, step; Mixing the raw material powders to prepare a mixture; And a step of formulating the mixture. The method for producing a hair growth promoting composition, which is produced by the method, and which does not show toxicity and side effects on the human body, smoothes blood circulation in the body, To promote hair growth by allowing the hair growth promoting composition to be supplied.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for promoting hair growth,

The present invention relates to a process for producing a hair growth promoting composition and a hair growth promoting composition prepared therefrom, and more particularly, to a process for producing a composition for promoting hair growth, which comprises pulverizing and kneading a natural component into a ring, And more particularly to a composition for promoting hair growth.

It is known that about 100 to 150 thousand hairs exist in human body, and each hair grows at different cycles through growth, regenerator and pausing period, and then falls off from the skin. This cycle is repeated over 3 to 6 years, resulting in 20 to 100 hairs averaged on a daily basis.

In addition to the inherited factors such as recent genetic factors, the blood circulation and endocrine system is not smooth due to the increase in stress, Westernized diet patterns, excessive secretion of male hormones, overwork, shampoo, mousse, There is a surge in the number of modern people who suffer hair loss due to failure. In general, hair loss refers to a state in which a hair growth part is shortened and hair of a nipple part to be normally present, in particular a hairy hair part, is maintained in a resting state or is reduced in size. In modern society, the number of people suffering from hair loss continues to increase, and the age is also lower, and the hair loss population of women is increasing not only for men.

Conventionally, in the treatment or prevention of such hair loss, medicines such as propecia, which is a therapeutic agent for oral hair loss, which inhibits testosterone, which is a male hormone, have been used, but there have been problems such as side effects due to hormone disturbance and difficulty in using by women. Currently, typical drugs that promote hair growth include minoxidil and pinasteride, which can cause side effects such as dermatitis when used for a long period of time. There is a problem that inflammation may occur in the skin even when the local stimulation of the scalp or the surgical treatment is used. Therefore, it is necessary to develop a hair loss treatment agent which does not accompany side effects even after long-term use.

On the other hand, the use of a pharmaceutical composition derived from a natural product is increasing worldwide in the field of drug development. Pharmaceutical compositions derived from natural products are reported to have relatively few side effects compared to drugs based on conventional chemicals.

It contains protein, fat, carbohydrate, fiber, ash, calcium, phosphorus, iron, sodium, potassium, vitamin, lysine alginic acid and glutamic acid. It strengthens heart and liver and helps blood circulation. , And is known to have a preventive effect on diseases such as heart disease. However, there is a problem of causing diarrhea when it is taken for a long time.

Hansikucho isolates the bacteria and acts to coagulate blood. The juice of Hansuksikcho has the effect of darkening the color of the hair even more.

Sasao improves kidney and liver function and helps protein and vitamin metabolism smoothly. It also improves thyroid function, promotes the secretion of hormones including thyroid hormones, and smoothes the endocrine system and metabolism. The anthraquinone derivatives contained in the roots of Sasao have an effect on stimulation of the central nervous system and intestinal motility.

Brewer's yeast is a nutritional food containing a large amount of vegetable protein and minerals. It has the effect of preventing and eliminating the blood of the body, facilitating blood circulation and promoting digestion.

Mulberry leaves are very high in minerals such as calcium, potassium and iron, and they contain rich amino acids as constituents of proteins. Mulberry leaves are known to lower blood pressure, relieve diabetes mellitus, and promote diuretic and anticancer effects.

Kelp is rich in inorganic salts and has the effect of lowering blood pressure.

Angelica contains coumarin and essential oil components. It works calmingly and squeezing blood pressure. It also replenishes insufficient blood and stimulates metabolism.

The celestial gods include coumarin components such as cnidylid, ligustilide, licorice, and butylphthalide, and essential oils containing mannitol. The cingulate gland restores the central nervous system activity to normal, dilates the peripheral blood vessels to lower blood pressure. In addition, the astrocytoma has an effect of facilitating blood circulation in the body.

Korean Patent No. 10-0705981 (Apr. 04, 2007) Korean Registered Patent No. 10-1205209 (2012.11.21)

Shin, H., Lee, J. 2013. Hair Growth Activity of Crataegus pinnatifida on C57BL / 6 Mouse Model. Phytother. Res. 27: 1352-1357.

The present invention aims to provide a method for producing a composition for promoting hair growth, which is capable of promoting hair growth by being absorbed into the human body through oral administration without exhibiting toxicity and side effects in the human body.

It is another object of the present invention to provide a composition for promoting hair growth, which is produced by the above production method.

According to one aspect of the present invention, there is provided a method for preparing a raw material powder, comprising the steps of: preparing a raw material powder by crushing black bean curd, hanchikcho, dassau, brewer's yeast, mulberry leaf, kelp, The prepared raw material powder was mixed with 30 to 35% by weight of black beans, 25 to 30% by weight of Hansikscho, 5 to 10% by weight of Sasao, 5 to 10% by weight of brewer's yeast, 5 to 10% 5 to 10% by weight of Angelica gigas and 5 to 10% by weight of Angelica keiskei koidz .; And a step of formulating the mixture. The present invention also provides a method for producing a pharmaceutical composition for promoting hair growth.

In addition, in the step of preparing the raw material powder, the black bean can be pulverized to a particle size of 50 to 100 microns, such as soybean, hanchikcho, hapthouse, brewer's yeast, mulberry leaf,

Further, in the step of preparing the mixture, 5 to 10% by weight of vitamins in powder form may be further added.

In addition, the step of formulating the mixture may include a granulating step of adding the purified water to the mixture to form and drying the mixture; A granulation step of granulating the granules prepared in the granulation step; And drying and sterilizing the ring manufactured in the swelling step.

Also, in the granulation step, 5 to 20 parts by weight of purified water may be added to 100 parts by weight of the mixture.

According to another aspect of the present invention, there is provided a pharmaceutical composition for promoting hair growth, which is produced by the above production method.

In addition, the pharmaceutical composition may be in the form of a ring.

The composition for promoting hair growth, which is produced by the manufacturing method according to one aspect of the present invention, does not exhibit toxicity and side effects in the human body, facilitates blood circulation in the body, and provides sufficient nutrition to hair follicles and hair follicles. Through this, hair growth can be promoted.

FIG. 1 is a view showing a result of photographing an appearance of a hair removal part in an experimental animal and confirming the hair growth promoting effect of the hair growth promoting composition of the present invention, and FIG.
FIG. 2 is a graph showing the hair growth promoting effect of the composition for promoting hair growth of the present invention measured by measuring the hair density at the hair removal site in an experimental animal,
FIG. 3 is a graph showing the results of the composition for promoting hair growth of the present invention not affecting the body weight of an experimental animal.

The present invention relates to a method for preparing a raw material powder, comprising the steps of: preparing a raw material powder by crushing black bean curd, hanchikcho, dassau, brewer's yeast, mulberry leaf, kelp, The prepared raw material powder was mixed with 30 to 35% by weight of black beans, 25 to 30% by weight of Hansikscho, 5 to 10% by weight of Sasao, 5 to 10% by weight of brewer's yeast, 5 to 10% 5 to 10% by weight of Angelica gigas and 5 to 10% by weight of Angelica keiskei koidz .; And a step of formulating the mixture. The present invention also relates to a method for promoting hair growth and a hair growth promoting composition prepared from the same.

Hereinafter, one embodiment of the method for producing a composition for promoting hair growth in the present invention will be described in more detail.

According to one aspect of the present invention, there is provided a method for producing a composition for promoting hair growth, which comprises black bean curd, hanchikcho, dassau, brewer's yeast, mulberry leaf, kelp, angelica, mantis and vitamin.

The method for preparing a hair growth promoting composition according to one aspect of the present invention includes a step of preparing a raw material powder by pulverizing raw black beans, mulberry, hansuo, brewer's yeast, mulberry leaf, kelp, Black bean curds, Hanshiku, Sasae, Mulberry leaves, Kelp, Angelica and Mandelia can be washed and dried before crushing. The washing and drying are performed sequentially.

The method of washing the black bean, soybean, mulberry leaf, seaweed, mulberry leaf and seaweed is not particularly limited, and can be washed using, for example, water. The Angelica gigas and Angelica gigas can be washed using steam. It is preferable to use a steam of 100 DEG C or higher in order to prepare the raw material by the law, and it is preferable that the steam is lower than 110 DEG C in terms of reducing destruction of the effective ingredient contained in each raw material.

Next, the cleaned black eyes dry beans, hanchikcho, dashi, mulberry leaves, kelp, Angelica gigas, and astragalus. The drying method is not particularly limited and may be carried out by a method known in the art. For example, it can be carried out using a far-infrared ray drier. The drying temperature is not particularly limited, but is preferably less than 60 DEG C from the viewpoint of reducing destruction of the active ingredient contained in each raw material. More preferably less than 50 캜. The water content of each raw material is preferably dried to 1 to 10%. The water content is more preferably 1 to 5%.

Next, each of the above-mentioned black eyes is pulverized into soybean, hanchikcho, seaweed, brewer's yeast, mulberry leaf, kelp, Angelica gigas and Angelica keiskei. The pulverization is carried out to powder each raw material and can be carried out by methods known in the art. By pulverizing each raw material in this step, mixing of each raw material can be easily performed in the following mixing step. It is preferable that the pulverization of each raw material is performed for each raw material in order to control the particle size of the raw material powder to be produced through the pulverization. It is preferable that the particle size of each raw material obtained by pulverization is in the range of 50 to 100 microns. When the particle size of each raw material powder falls within the above-mentioned range, it is easy to formulate the final composition even though the loss of raw material is reduced in the manufacturing method according to the present invention, and when the formulated composition is orally administered, .

The method for preparing a composition for promoting hair growth according to one aspect of the present invention includes a step of preparing a mixture by mixing the prepared raw material powder.

In the mixing, each raw material powder contains 30 to 35% by weight of black beans, 25 to 30% by weight of pine needles, 5 to 10% by weight of sewage, 5 to 10% by weight of brewer's yeast, 5 to 10% 5 to 10% by weight of Angelica gigas Nakai, 5 to 10% by weight of Angelica keiskei koidz. The composition of the raw materials contained in the composition of the present invention as described above is controlled by the blending and compatibility of the respective raw materials, and the composition in which the raw materials are mixed according to the blending improves blood circulation and nourishes the hair root to promote hair growth . In the composition of the present invention, there is a problem that if each raw material is added in an amount less than the minimum addition amount within the above range, the effect thereof can not be expected. If the addition amount exceeds the maximum addition amount, . Specifically, when the content of the black bean is less than 30% by weight, the effect due to the addition of black bean beans is reduced. When the content exceeds 35% by weight, diarrhea is caused by long-term administration, There is a problem of affecting the overall efficacy of the composition. If the content is less than 25% by weight, the effect due to the addition of Phellinus vulgaris is reduced. If the content is more than 30% by weight, it may be difficult to take the pungent flavor due to a strong odor. When the content of each of the above ingredients is less than 5% by weight, the effect of addition of each ingredient can not be exhibited. When the content of each ingredient exceeds 10% by weight, the content of other active ingredients There is a problem of affecting the overall efficacy of the composition. Each of the raw material powders may be mixed in a blender at a content within the above range to prepare a mixture.

If desired, vitamins in powder form may be added to the mixture. It is preferable that the vitamin is selected from water-soluble vitamins that do not cause accumulation problems in the body. The vitamin may be added to the mixture in an amount of 5 to 10% by weight. The powder particle size of the vitamin is preferably in the range of 50 to 100 microns as with the other raw materials contained in the mixture

A method for producing a composition for promoting hair growth according to one aspect of the present invention includes the step of formulating the mixture.

The formulations are formed and processed so that the composition for promoting hair growth of the present invention can be easily ingested. The form of the molded and processed composition obtained through the above formulation is not particularly limited, and examples thereof include a ring form, Tablet, or powder. In order to maximize the efficacy of the raw materials contained in the composition of the present invention, it is preferable to be produced in a ring form. In order to produce the hair growth stimulating composition of the present invention in the form of a ring, the formulation includes a granulation step in which purified water is added to the mixture to formulate and then dried; A granulation step of granulating the granules prepared in the granulation step; And a step of drying and sterilizing the ring manufactured in the above-mentioned pumping step. Specifically, granules were first prepared in the granulation step by blending 100 parts by weight of the mixture and 5 to 20 parts by weight of purified water in the granulation step. The granules thus prepared may be dried to a moisture content of 1 to 5%, and then subjected to pressure under pressure by applying a pressure to the granules. Next, the hair for promoting hair growth of the present invention, which is produced in the form of a ring, can be obtained by drying and then sterilizing the circulated ring.

As described above, according to the manufacturing method according to one aspect of the present invention, it is possible to easily take the oral cavity, and it is easy to use, does not show toxicity and side effects on the human body, smoothes blood circulation in the body, The hair growth promoting composition can be prepared.

Hereinafter, the present invention will be described in more detail with reference to the following examples and comparative examples in order to facilitate understanding of the present invention. It will be apparent to those skilled in the art that these embodiments are illustrative of the present invention and are not intended to limit the scope of the appended claims and that various changes and modifications may be made to the embodiments within the scope and spirit of the invention , And it is natural that such variations and modifications fall within the scope of the appended claims.

Example

&Lt; Preparation of pill for promoting hair growth >

The raw black bean, Hansuksikcho, Sasae, Mulberry leaf and Sea tangle were washed with water, and Angelica gigas and Angelicae were prepared by washing vapor method at 103 ° C for 60 minutes. Black bean curd, Hansuksikcho, Hwasoo, Mulberry leaf, Kelp, Angelicae, and Cantilever were washed and dried in a far infrared ray dryer at 45 ° C. 12 hours for black bean and mulberry leaves, 8 hours for Hansuksikcho, 24 hours for Hansuo, and 36 hours for kelp, Angelica gigas and Mandelia. Brewer 's yeast was prepared by drying the by - products after beer brewing, and the vitamins were dried in a far infrared ray dryer at 45 ° C for 16 hours. Each raw material was pulverized to a particle size of 74 microns using a ball mill to obtain a raw material powder.

The raw material powder obtained by the above pulverization was mixed with 32 wt% of black beans, 26 wt% of Hansiksiko, 6 wt% of HASO, 6 wt% of brewer's yeast, 6 wt% of mulberry, 6 wt% of kelp, 6 wt% The mixture was put into a cone blender at a ratio of 6% by weight of vitamin and mixed at 12,000 rpm for 30 minutes to prepare a mixture.

10 parts by weight of purified water was added to 100 parts by weight of the mixture, and granules were prepared in a granulator, followed by drying at 45 ° C for 12 hours using a far-infrared drier. Next, the circulation was set at 10 rpm, the Laura was set at 6 at a total pressure of 10, and the volume was changed to 3 rpm. The prepared rings were dried in a far-infrared ray dryer at 45 ° C for 12 hours and then sterilized for 5 to 7 minutes using a sterilized far infrared ray sterilizer. Next, using a four-sided wrapping machine, the bundles were heated and packaged at 120 ° C and 135 ° C to produce a hair-promoting ring.

&Lt; Measurement of Efficacy of Hair for Promoting Hair Growth &

C57BL / 6 mice were used as models of depilatory animals. After 5-week-old male C57BL / 6 was purchased, the animals were adapted to the environment of the animal breeding room for one week, and the individuals whose abnormalities occurred during the purifying period and the individuals whose normal body weight did not increase were excluded. Respectively. The animals were fed with feed and drinking water in an animal breeding room set at a temperature of 22 ± 3 ° C, a relative humidity of 50 ± 20%, a ventilation period of 10 to 15 cycles, an illumination period of 12 hours and an illumination of 150 to 300 Lux, And isolated during the test period. The rats were fed with animal feed (Cargill Aguri Purina) and freely consumed with filtered UV - irradiated water. After separating the mice, the mice were anesthetized and the back hair was removed using an electric razor. To remove hair follicles and fine hair remaining in the skin, a hair removal agent (NiClin, Ildong Pharm) was applied and allowed to stand for 5 minutes. Were removed until they were invisible. After a day of recovery, oral administration of the hair growth promoting ring of the present invention and the positive control group of the present invention were started. The prepared hair growth promoting rings of the present invention were dissolved in sterilized distilled water and orally administered. Minimal administration of water alone and minoxidil and finasteride, which are drugs used as a hair loss treatment agent, were administered as positive control. Minoxidil was administered at a dose of 0.51 mg / kg, based on the adult dose per day, and the finasteride was administered at a dose of 0.1 mg / ml. The experimental group and the control group were subjected to general symptom observation at least once a day, and the hair growth was checked at 1, 6, 12, 17, and 21 days, and the change in body weight was measured. The number of experimental groups belonging to each group was 8.

The hairy state was mixed with zoletil and rumun at a weight ratio of 6: 4, diluted with distilled water to 1/5, and injected with 100 쨉 l per dose. Anesthetized animals were examined with a digital camera to determine the appearance of the epilating area The results are shown in Fig. In FIG. 1, N means a negative control, M a minoxidil-treated positive control, F a pinasteride-treated positive control, and E an experimental group to which the hair growth stimulating ring of the present invention was administered.

Referring to FIG. 1, no hair was observed in all the control and experimental groups at the 6th day of the experiment, and hair growth was observed in the back of mice from day 12. On the 6th day, the negative control group showed that the majority of the mice in which hair follicles were darkly expressed in the hair follicles rather than the hairy parts such as the fluffy hair, whereas in the minoxidil treated positive control group, the skin tone was totally changed to black, the thin hair was covering the skin and the pinastellite- Showed similar results to those of the minoxidil-treated control group. In the experimental group administered with the hair growth promoting ring of the present invention, short hair follicles were localized in black skin tone. On the 17th day, the distribution of mother - in - law was wider than the distribution of short hair and the thickness of hair was thickened in all control and experimental groups. In the negative control group, 70 to 80% of the epilated area was covered with the hair, and in the positive control group and the experimental group, hair growth was observed in more than 90% of the epilated area. On day 21, the hair grew to such an extent that there was no difference between groups in all control and experimental groups.

The density of the hair was analyzed using the skin measuring device (Aramhuvis skin diagnosis system) on the right shoulder area based on the vertebrae and the results are shown in Fig. In FIG. 2, N means a negative control, M means a minoxidil-treated positive control, F means a pinasteride-treated positive control, and E means an experimental group administered with the hair growth promoting ring of the present invention.

Referring to FIG. 2, there was no change in the epilated area on day 6, and it was confirmed that the hair growth was progressed in all the control and experimental groups from day 12. In the negative control group, thin hair appeared short in the skin, whereas in the positive control group and the experimental group, the coarse hair was distributed at a higher density than the negative control group. On the 17th day, the hair of the negative control group was in the form of a short hair, whereas in the positive control group and the experimental group, the hair was covered with the hair so that the skin could not be seen.

The weight of each mouse belonging to each group was measured using an electronic balance at a constant time from the end of the adaptation period to the day of the experiment, and the results are shown in FIG.

Referring to FIG. 3, it can be seen that no significant difference was observed between the control group and the experimental group in each group.

The adverse effects of the hair growth promoting rings of the present invention were confirmed by observing the hair growth state on the last day of the experiment and then visually observing the appearance and internal organs of the individual by autopsy and measuring the organ weight. During the test period, deaths and abnormal findings were not observed due to the treatment of the test substance. As a result of visually observing the appearance and internal organs by autopsy of individuals, it was found that all the animals used in the experiment had bleeding, spots, edema, abnormal tissues No abnormality such as generation was found. The weights of organs were measured in liver, spleen, kidney, epididymis and testis. The measured results are shown in Table 1 below. The units in Table 1 are g values and all results are expressed as means ± SD (mean ± SD), and the significance of the negative control at the level of p <0.01 was tested using a corresponding sample student's t-test .

Negative control group Minoxidil treated group Pinasteride treated group Hair growth accelerating ring liver 1.144 + 0.036 1.252 + 0.038 1.198 ± 0.051 1.228 + 0.024 spleen 0.073 ± 0.003 0.098 ± 0.007 * 0.092 0.005 0.079 ± 0.003 kidney 0.318 ± 0.006 0.354 + 0.013 0.348 + 0.011 0.330 0.011 Epididymis 0.046 ± 0.006 0.044 ± 0.005 0.056 ± 0.007 0.044 ± 0.002 testicle 0.158 + 0.016 0.187 ± 0.006 0.180 0.009 0.171 ± 0.009

Referring to Table 1, it can be seen that the weights of the organs did not show a significant difference between the experimental group treated with the hair growth promoting ring of the present invention and the negative control group.

Referring to the results of FIGS. 1 to 3 and Table 1, it can be confirmed that the hair growth promoting pores produced according to the manufacturing method of the present invention exhibit excellent hair growth promoting effect similar to minoxidil and finasteride without exhibiting toxicity.

Claims

Preparing a raw material powder by crushing black bean curd beans, Hansuksikcho, Sasao, brewer's yeast, mulberry leaves, kelp, Angelica gigas and Astragalus;
The prepared raw material powder was mixed with 30 to 35% by weight of black beans, 25 to 30% by weight of Hansikscho, 5 to 10% by weight of Sasao, 5 to 10% by weight of brewer's yeast, 5 to 10% 5 to 10% by weight of Angelica gigas and 5 to 10% by weight of Angelica keiskei koidz .; And
And a step of formulating the mixture. &Lt; RTI ID = 0.0 > 11. < / RTI >

The pharmaceutical composition for accelerating hair growth according to claim 1, wherein, in the step of preparing the raw material powder, the black hair is pulverized to a particle size of 50 to 100 microns, wherein the beans, hanchikcho, huasoo, beer yeast, mulberry leaf, &Lt; / RTI >

The method for manufacturing a pharmaceutical composition for promoting hair growth according to claim 1, wherein 5 to 10% by weight of vitamin in powder form is further added in the step of preparing the mixture.

2. The method of claim 1 wherein the step of formulating the mixture comprises
Adding granular water to the mixture to formulate and dry the mixture;
A granulation step of granulating the granules prepared in the granulation step; And
And drying and sterilizing the ring manufactured in the step of swelling.

5. The method for manufacturing a pharmaceutical composition for promoting hair growth according to claim 4, wherein 5 to 20 parts by weight of purified water is added to 100 parts by weight of the mixture in the granulation step.

A pharmaceutical composition for promoting hair growth, which is produced by the production method according to any one of claims 1 to 5.

The pharmaceutical composition for promoting hair growth according to claim 6, wherein the pharmaceutical composition is in the form of a ring.