KR20150118363A - The herbal mixture extract as an active ingredient for prevention and treatment of depression composition and its manufacture method - Google Patents

Abstract

The present invention relates to a composition for preventing and treating depression comprising mixed herbal extracts as active ingredients and a producing method thereof and, specifically, to a composition for preventing and treating depression comprising mixed herbal extracts as active ingredients and a producing method thereof which have effects on preventing and treating depression by producing granules, powders and pills through an extraction, concentration and powder step of mixed herbal extracts using Nelumbinis Semen, Scutellaria baicalensis Geogi, Polygala tenuifolia Willdenow as main raw materials.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing and treating depression and a method for preparing the same,

The present invention relates to a composition for preventing and treating depression and a method for producing the same, and more particularly to a composition for preventing and treating depression comprising an extract of a mixed herbal medicine and a method for preparing the herbal composition, The present invention relates to a composition for preventing and treating depression and a method for preparing the same, which comprises an extract of a mixed herbal medicine which is effective for prevention and treatment of depression.

In general, stress is injured when the stimulus on the living body becomes more than a certain level. In this case, the living body is defined as a phenomenon showing a nonspecific systemic syndrome in response to a certain threat regardless of the type of the stimulus.

A typical symptom of stress is depression, which is known to be an imbalance of neurotransmitters in the brain (neurotransmitters are signal substances secreted by neurons, which transmit information from one neuron to another. And histamine, serotonin, dopamine, etc.).

The main symptoms of depression include persistent depression, decreased motivation, decreased interest, weight loss associated with sleep deprivation, loss of appetite or appetite, depressed attention, women's postpartum depression, and menopausal depression.

Antidepressant drugs for depression include tricyclic antidepressants, monoamine oxidase inhibitors (MAOI) and selective serotonin reuptake inhibitors (SSRIs), which inhibit the reuptake of amine-based neurotransmitters secreted from the nerve endings ) Are used.

For example, Korean Patent Registration No. 10-0770194 discloses a serotonin reuptake inhibitor, which relates to phenyl-piperazine derivatives as a serotonin reuptake inhibitor, and more particularly relates to a phenyl-piperazine derivative which is effective for the treatment of depression and anxiety Lt; / RTI >

The above-mentioned prior art is effective for the treatment of depression and anxiety. However, adverse effects of the serotonin reuptake inhibitor on the long-term administration cause gastrointestinal disorders such as diarrhea, nausea and vomiting, and cause anxiety, anxiety, sleeping disorder, weight gain, And a withdrawal phenomenon occurs.

Therefore, unlike the serotonin reuptake inhibitor, which has a fear of adverse effects when administered over a long period of time, there has been proposed a technique relating to a composition for preventing and treating depression, which has no adverse effect on the human body by using an extract of a natural herb medicine. 10-0780333, which is directed to a pharmaceutical composition for preventing and treating anxiety and depression including bramble extract, and more particularly to a health functional food using the composition.

Although the above-mentioned prior art can eliminate the side effects of the serotonin reuptake inhibitor, it disadvantageously lacks effects on anxiety and depression, and fails to improve sleep, appetite and concentration, merely serving as a health functional food.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems, and its object is to prevent and treat depression.

In addition, the mixed medicinal herb extract containing mainly livestock meat, golden, and raw materials is intended to improve sleeping, appetite and concentration.

Also, it is an object of the present invention to provide a method for producing a composition for preventing and treating depression, which comprises an extract of a mixed crude drug mainly containing pectin, gold, and ground raw materials as an active ingredient.

Further, it is an object of the present invention to provide a granule, a powder, and a pill so as to make it easy for a user to take it easily.

The present invention is a composition for preventing and treating depression comprising an extract of a mixed herbal medicine extracted from a mixed herbal medicine consisting of pomegranate, golden, and ground.

In addition, the present invention is a composition for preventing and treating depression comprising an extract of a mixed herbal medicine extracted from a mixed herbal medicine comprising pansy meat, gold, and raw pork.

In addition, the present invention is a composition for preventing and treating depression, which comprises an extract of a mixed herbal medicine extracted from a mixed herbal medicine which further comprises pine needle meat, acidophilus, and white bokbyeon in pomegranate, golden, and ground.

In addition, the present invention is a composition for preventing and treating depression comprising an extract of a mixed herbal medicine extracted from a mixed herbal medicine comprising pomegranate, golden, raw ground ginseng, ginseng, omija and ginger.

In addition, the present invention is a composition for preventing and treating depression comprising an extract of a mixed herbal medicine extracted from a mixed herbal medicine, which further comprises pomegranate, golden, raw pine, pine needle, sanjiton, Baekbokryeong, ginseng, omija and ginger.

The method of the present invention may further comprise the steps of (A1) extracting the mixed herbal medicine extract from the mixed herbal medicine and (A2) concentrating the mixed herbal medicine extract of step (A1) (C1) of preparing a granule, a powder and a granule by mixing a concentrated herbicide concentrate of step (A2) and a mixed herbicide powder of step (B1) do.

As described above, the mixed herbal medicine extract having the main ingredient of the prawn, golden, and ground of the present invention has the effect of preventing and treating depression.

In addition, a mixed herbal medicine extract containing mainly livestock meat, golden and raw materials has an effect of improving sleep, appetite and concentration.

The present invention also provides a method for preparing a composition for the prevention and treatment of depression using an extract of a mixed herbal medicine as a main ingredient of pomegranate, golden, and ground.

In addition, the granules, powders, and pills are manufactured by the above-described manufacturing method, and are convenient for the user to easily take.

1 is a flow chart showing a method for preparing a composition for preventing and treating depression, which comprises an extract of a mixed herbal medicine as an active ingredient according to an embodiment of the present invention.

Hereinafter, the present invention will be described in detail.

An embodiment of the present invention comprises a mixed herbal medicine extract extracted from a mixed herbal medicine extract made of pomegranate, golden, and ground. In the composition of one embodiment, 8 to 92% by weight of extract from pine nut, 4 to 62% And 4 to 30% by weight of the extract.

The livestock meat is the seed of the lotus (Nelumbo nucifera Gaetner) belonging to the Nymphaeaceae and has been stripped of seed coat. The efficacy of pomegranate juice helps to stop the diarrhea by watching the spleen, to help the kidneys, to protect the regularity, to refresh the body and to relax the mind and body. The neferine component of soft meat has an antianxiety effect, and the scopolamine ingredient has improved memory and antidepressant activity.

When the extract of the present invention is used in an amount of less than 8% by weight based on the total weight of the composition of the present invention, the absorption of nephelin and scopramin is low and thus the antidepressant activity is lowered. When the extract is more than 92% by weight, People have a problem that can cause constipation.

The gold is the root of the perennial herbaceous (黄 芩) (Scutellaria baicalensis Geogi) belonging to the Labiatae. The golden effect is to lower the heat in the body, to dry the wet, to detoxify, to detoxify the body's poison, to release the heat in the body, to release heat from the blood, and to comfortably preserve the fetus during pregnancy do. The gold oroxylin A component has a memory-restoring effect on memory loss due to physical damage such as stroke.

In the composition of the present invention, the gold extract of the present invention has a low absorption of orroxylin in the body when it is less than 4% by weight based on the total weight of the composition of the present invention. There is a problem that can be provoked.

This is the root of the Polygala tenuifolia Willdenow, which is collected in spring and autumn and dried in the sun. The efficacy of the paper makes the mind relaxed, the body and the mind stabilized, and the body's wall removed to improve the circulation. Tenuifolin and tenuifoliside B components of the leaves have cranial neuroprotection and memory improving actions.

When the extract of the present invention is used in an amount of less than 4% by weight based on the total weight of the composition of the present invention, the cervical neuroprotective effect is weakened and the effect of improving memory recovery is not exhibited. If it exceeds 30% by weight, vomiting, diarrhea, gastrointestinal disturbance, have.

Another embodiment of the present invention is a mixed herbal medicine extract which is extracted from a mixed herbal medicine extract made from a mixed herbal medicine which further comprises raw ginseng, gold, and raw ginseng. The composition of the present invention comprises 8 to 88% by weight of total flesh extract, 48 to 48% by weight of the extract, 4 to 24% by weight of the extract of leaf extract, and 4 to 20% by weight of the extract of Panax ginseng CA Meyer.

It is dried in the roots of Salvia miltiorrhiza Bunge belonging to Labiatae and is collected in spring and autumn and dried in the sun. The efficacy of Dansam removes the blood in the body by activating the blood, helps the blood, removes the body 's boils, and relaxes the mind and body. Dansam is used in the treatment of cardiovascular diseases, liver diseases, menstrual disorders, edema and insomnia in clinical practice, and has an effect of extending the sleeping time by activating the central nervous system.

The extract of Dansamp extract of the present invention is not effective for improving the sleep surface due to weak action on the central nervous system when it is less than 4% by weight based on the total weight of the composition of the other examples. If it is more than 20% by weight, there is a problem.

Another embodiment of the present invention is a mixed herbal medicine extract which is extracted from a mixed herbal medicine extract which is further comprised of pomegranate, golden, raw pork, yuzen meat, sanjoin and Baekbokryeong. In the composition of another embodiment, , 4 to 38% by weight of a golden extract, 4 to 18% by weight of a raw extract, 7 to 12% by weight of a canine extract, 8 to 12% by weight of an acidophyll extract and 4 to 12% .

The above-mentioned yongtan meat refers to the seed coat of Dimocarpus longan Lour. Belonging to the Sapindaceae family. The efficacy of yongtanjuk is to blend the energy of the heart and spleen, Blood (blood) is blessed. Corylagin, a kind of tannin, is an antihypertensive agent that stabilizes the body and mind. In addition, there are stress suppressing action, weight increasing action, immune enhancing action, and the like.

If the extract of the present invention is less than 7% by weight based on the total weight of the composition of the present invention, the effect of stabilizing the body and mind is weak, so that it can not take a good night's sleep and the fatigue can be felt more. Because of its warm nature, people who have a lot of body heat can not take it.

The sanjoin is a dried seed of Zizyphus jujuba Mill. Var. Spinosa Hu belonging to Rhamnaceae. The efficacy of Sanjo is to nourish the heart, help the liver, relax the mind, and collect the sweat. Sanjo is used as a sedative or sleeping medication to treat symptoms such as insomnia and discomfort caused by excessive excitement of the central nervous system. One of the alkaloid components of Sanjoin, sanjoinine A, has an anxiolytic effect.

In the composition of the present invention, the extract of the present invention is less than 8% by weight based on the total weight of the composition, which does not inhibit the excessive excitement of the central nervous system and does not help to treat insomnia. It is strong and affects pregnant women badly.

The Baekbok-ri is the sclerot of parasitic (pachyma hoelen Rumph.) And polyporaceae in the pine root. (茯神), skin (skin) is called 茯 피 skin, and the inside is purplish red is called 복 령 령 (茯 茯). It is called Baekbokryeong (白 茯), generally speaking, Baekbokryeong refers to. The efficacy of Baek Bok Byeongryeong makes the urine come out well, removes the moisture in the body, makes the spleen healthy, relaxes the mind, and stabilizes the mind and body. Caffeine-induced excitement is suppressed to have sleep improvement effect.

In case of less than 4% by weight based on the total weight of the composition of the present invention, the extract of the present invention may cause anxiety and nervousness because it does not resolve nerve hypersensitivity. If the extract is more than 12% by weight, have.

Another embodiment of the present invention is a mixed herbal medicine extract which is extracted from a mixed herbal medicine comprising pomegranate, golden, ground ginseng, gentian ginseng, omija, and gardenia, Composition for prevention and treatment of depression containing 4 to 15% by weight of a gold extract, 4 to 7% by weight of an extract of an earthy extract, 5 to 40% by weight of a true angelica guinea pig extract, 15 to 24% by weight of an Omija extract, and 3 to 6% .

The Angelica gigas Nakai is a root of the Angelica gigas Nakai belonging to the Umbelliferae. The main component of Angelica gigas Nakai is a coumarin derivative, which is decursinal. The efficacy of True Angelica smoothes, calms, analgesic, anti-inflammation, antibacterial, landscaping, and defecation. Other effects may promote oxygen circulation in the myocardium, which may lower blood pressure and stabilize the mind and body.

In the composition of the present invention, the Angelica gigantosa extract of the present invention is less than 5% by weight based on the total weight of the composition of the present invention, thereby causing anxiety due to lack of mental and physical stability. In case of exceeding 40% by weight, .

The above-mentioned Schizandra chinensis Baillon belongs to the Schizandraceae mature fruit. The efficacy of Omija is the soothing effect of cough and sputum, supplying the essence of the kidney, supplying the essence, keeping the sweat away, protecting the kidney period, stopping the diarrhea, relaxing and stabilizing the mind. Schizandrol A, an ingredient of Omija, has an effect of prolonging the sleeping time. It is known that Omija extract lowers blood pressure and decreases heart rate in relation to cardiovascular.

In the composition of the present invention, the amount of the schizandrole A in the body is less than 15% by weight based on the total weight of the composition of the present invention, There is a problem that difficulties may appear.

The gardenia is a mature fruit of gardenia (Gardenia jasminoides Ellis), an evergreen shrub belonging to the Rubiaceae. The effectiveness of the gardenia eliminates the anxiety and aggravation of the body, reduces the heat in the body, helps the diuretic effect, cools the blood in the body, and detoxifies. Gardenia is known to have an effect on sleep duration and blood pressure lowering.

In case of less than 3% by weight based on the total weight of the composition of the other embodiments of the present invention, the effect of extending the sleeping time is lowered, and when it exceeds 6% by weight, symptoms such as stomach dysfunction, .

Another embodiment of the present invention comprises a mixed herbal medicine extract which is extracted from a mixed herbal medicine which further comprises pomegranate, golden, raw pine, raisins, sanjian, white roe, 8 to 12 wt% of pine needle extract, 7 to 12 wt% of gold extract, 4 to 6 wt% of raw extract, 4 to 6 wt% of raw ginseng, 7 to 12 wt% 4 to 6% by weight of Lycopersicon esculentum extract, 5 to 40% by weight of true angelica orientalis extract, 15 to 23% by weight of Omija, and 3 to 6% by weight of gardenia extract.

Hereinafter, preferred embodiments of the present invention will be described with reference to the accompanying drawings, and it is to be understood that the present invention is not limited thereto.

 (A1) of extracting a mixed herbal medicine extract from the mixed herbal medicine and a step (A2) of preparing a concentrated herbal concentrate by concentrating the mixed herbal medicine extract of the step (A1) and a step (A2) of drying and pulverizing the mixed herbal medicine (C1) for preparing a granule, a powder and a pill are prepared by mixing the concentrate of the herbicide concentrate of step (A2) and the powder of the mixed herbicide of step (B1).

In step (A1) of extracting the mixed herbal medicine extract from the mixed herbal medicine, an extraction solvent in which purified water and a food alcohol are mixed at a weight ratio of 8: 2 to 5: 5 is prepared. The food alcohol is preferably ethanol.

When the weight ratio of the water to the alcohol is less than 5 parts by weight, the alcohol component is relatively increased, and the alcohol remains after the extraction, so that a process for removing the alcohol is added. If the weight ratio of the alcohol to the alcohol is more than 8 parts by weight, And thus the extracts of the herb medicine are not uniformly extracted.

First, the mixed herbal medicine is thoroughly cleaned and mixed. Then, 1,000 to 5,000 mL of the above mixed extraction solvent is added, and then the mixed herbal extract is extracted in a vacuum state at a temperature of 75 to 95 ° C for 8 to 10 hours (A1) .

When the mixed herbal medicine is formulated, it may further comprise a group consisting of pomegranate, golden, and ground or a group consisting of pomegranate, golden, and ground or a group consisting of pheasant, golden, Or a group consisting of pomegranate ginseng, omija, and gardenia in the group consisting of pomegranate, golden, and ground, or a group consisting of pheasant, golden, It also contains more ingredients.

After the mixed herbal medicine extract is obtained in the step (A1), the step (A2) of concentrating the mixed herbal medicine extract of the step (A1) is carried out. 1,000 to 5,000 mL of the crude herbal medicine extract is concentrated by vacuum low-temperature method to prepare a concentrated herbal concentrate of 500 to 1,000 mL.

The vacuum low-temperature thickening method is a method of concentrating a vacuum-applied state at a low temperature (40 to 90 ° C) in order to concentrate a substance to be thermally influenced or a substance to be oxidized by air.

In the next step, step (B1) of drying and pulverizing the mixed herbicide is carried out. In step (B1), the mixed herbicide is thoroughly washed and blended, dried in a drier at a temperature of 65 to 75 ° C for 8 to 10 hours, and then 100 to 400 mesh mixed herbicide powder is prepared.

When the mixed herbal medicine is formulated, it may further comprise a group consisting of pomegranate, golden, and ground or a group consisting of pomegranate, golden, and ground or a group consisting of pheasant, golden, Or a group consisting of pomegranate ginseng, omija, and gardenia in the group consisting of pomegranate, golden, and ground, or a group consisting of pheasant, golden, It also contains more ingredients.

A concentrated herbal concentrate is prepared in the step (A2), and a granulated product, a powder and a granule are prepared in the following manner (C1) after the mixed herbal powder is prepared in the step (B1).

The mixture concentrate and the excipient (corn flour) are mixed in a weight ratio of 1: 1 to 4: 1, followed by lyophilization to prepare granules.

The excipient is added for imparting a suitable hardness or shape to the medicament or added for the purpose of making the medicament easy to handle by giving a certain weight when the amount of the main agent is small. If the concentration of the concentrated herbicide concentrate is less than 1 part by weight of the excipient, the effect of depression is not exhibited. If it exceeds 4 parts by weight of the excipient, it is difficult to agglomerate the concentrated herbicide concentrate and the excipient.

The mixed concentrate of the herbicidal herbicide and the mixed herbicide powder are mixed at a weight ratio of 1: 1 to 4: 1, dried at a temperature of 65 to 75 ° C for 8 to 10 hours, and 100 to 400 mesh of a powder is prepared.

50 to 450 g of glutinous rice and 500 to 1,500 mL of purified water are further added to 100 to 400 g of the powder, and the pellet is produced with a diameter of 3 to 7 mm.

Hereinafter, the production examples, examples and comparative examples of the present invention will be described in detail.

The following Production Examples, Examples and Comparative Examples are merely illustrative of the present invention, and the present invention is not limited to the following Production Examples, Examples and Comparative Examples.

< Manufacturing example  >  Mixed extraction solvent Manufacturing example

The mixed extraction solvent was prepared by mixing purified water and alcohol (ethanol) for food at a weight ratio of 7: 3.

< Example  1>  Of depression prevention and treatment composition Manufacturing example  One

Production Example 1 of the composition for the prevention and treatment of depression of the present invention was prepared by mixing the following composition.

(A1) 1000 mg to 5,000 mL of the mixed extraction solvent of the above preparation example was added after mixing the herbal medicine of 50.0 wt% of the pear meat, 33.0 wt% of the gold and 17.0 wt% of the raw paper, and the mixture was vacuum-heated at a temperature of 75 to 95 ° C for 8 to 10 hours To obtain a mixed herbal medicine extract.

(A2) After obtaining the mixed crude drug extract, 1,000 to 5,000 mL of the mixed crude drug extract of step (A1) was concentrated to 500 to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrated herbal concentrate.

(B1) Fresh herb medicine of 50.0% by weight of pear meat, 33.0% by weight of gold and 17.0% by weight of raw paper was thoroughly washed and dried in a dryer at a temperature of 65 to 75 ° C for 8 to 10 hours, .

(C1) a granulating agent is prepared by lyophilization after mixing the concentrated herbicidal concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, and the concentrate of the mixed herbicide of step (A2) Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a 200-mesh powder. To 300 g of the powder was added 300 g of glutinous rice and 1,000 ml of purified water The pellet was then made with a diameter of 5 mm.

< Example  2 > for the prevention and treatment of depression Manufacturing example  2

Production Example 2 of the composition for the prevention and treatment of depression of the present invention was prepared by mixing the following composition.

(A1) 1,000 to 5,000 mL of the mixed extraction solvent of the above preparation example is added to 48.0% by weight of parenchyma, 26.0% by weight of gold, 14.0% by weight of raw paper and 12.0% And extracted in a vacuum state for 10 hours to prepare a mixed crude drug extract.

(A2) After obtaining the mixed crude drug extract, 1,000 to 5,000 mL of the mixed crude drug extract of step (A1) was concentrated to 500 to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrated herbal concentrate.

(B1) The herbal medicine of 48.0% by weight of the flesh of the parenchyma, 26.0% by weight of the ground, 14.0% by weight of the ground and 12.0% by weight of the raw ginseng was thoroughly washed and dried in a drier at a temperature of 65 to 75 ° C for 8 to 10 hours, A crude herbal medicine powder was prepared.

(C1) a granulating agent is prepared by lyophilization after mixing the concentrated herbicidal concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, and the concentrate of the mixed herbicide of step (A2) Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a 200-mesh powder. To 300 g of the powder was added 300 g of glutinous rice and 1,000 ml of purified water The pellet was then made with a diameter of 5 mm.

< Example  3>  Of depression prevention and treatment composition Manufacturing example  3

Production Example 3 of the composition for the prevention and treatment of depression of the present invention was prepared by mixing the following composition.

(A1) A herbal medicine containing 40.5% by weight of pectin, 21.0% by weight of gold, 11.0% by weight of ground rice, 9.5% by weight of lucerne, 10.0% by weight of acidophore and 8.0% And extracted in a vacuum state at a temperature of 75 to 95 캜 for 8 to 10 hours to prepare a mixed herbal medicine extract.

(A2) After obtaining the mixed crude drug extract, 1,000 to 5,000 mL of the mixed crude drug extract of step (A1) was concentrated to 500 to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrated herbal concentrate.

(B1) The herbal medicine of 40.5% by weight of the parenteral nutrition, 21.0% by weight of the ground, 11.0% by weight of the ground, 9.5% by weight of the yogurts, 10.0% by weight of the acidophilus and 8.0% by weight of the rosemary is thoroughly washed, After drying for 10 hours, 100 to 400 mesh mixed crude drug powder was prepared.

(C1) a granulating agent is prepared by lyophilization after mixing the concentrated herbicidal concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, and the concentrate of the mixed herbicide of step (A2) Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a 200-mesh powder. To 300 g of the powder was added 300 g of glutinous rice and 1,000 ml of purified water The pellet was then made with a diameter of 5 mm.

< Example  4>  Of depression prevention and treatment composition Manufacturing example  4

Example 4 of the composition for the prevention and treatment of depression of the present invention was prepared by mixing the following composition.

(A1) A herbal medicine containing 38.5% by weight of mature flesh, 9.5% by weight of gold, 5.5% by weight of raw paper, 22.5% by weight of true angelica, 19.5% by weight of Omija, and 4.5% by weight of gardenia was blended with 1,000 to 5,000 ml And extracted at a temperature of 75 to 95 ° C for 8 to 10 hours under vacuum to prepare a mixed herbal medicine extract.

(A2) After obtaining the mixed crude drug extract, 1,000 to 5,000 mL of the mixed crude drug extract of step (A1) was concentrated to 500 to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrated herbal concentrate.

(B1) After the herbal medicine of 38.5% by weight of the parenchymal tissue, 9.5% by weight of gold, 5.5% by weight of raw paper, 22.5% by weight of true Angelica, 30% by weight of Omija and 4.5% by weight of gardenia was thoroughly washed, And dried for 10 hours to prepare 100 to 400 mesh mixed crude drug powder.

(C1) a granulating agent is prepared by lyophilization after mixing the concentrated herbicidal concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, and the concentrate of the mixed herbicide of step (A2) Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a 200-mesh powder. To 300 g of the powder was added 300 g of glutinous rice and 1,000 ml of purified water The pellet was then made with a diameter of 5 mm.

< Example  5>  Of depression prevention and treatment composition Manufacturing example  5

Preparation Example 5 of the composition for the prevention and treatment of depression of the present invention was prepared by mixing the following composition.

(A1) 10.0% by weight of pine kernel, 9.5% by weight of gold, 5.0% by weight of raw paper, 5.0% by weight of ginseng, 9.5% by weight of lucerne, 10.0% by weight of acidophore, 5.0% 4.5% by weight of herbal medicine was mixed, 1,000 to 5,000 mL of the mixed extraction solvent of the above preparation example was added, and the mixture was extracted under vacuum at a temperature of 75 to 95 ° C for 8 to 10 hours to prepare a mixed herbal medicine extract.

(A2) After obtaining the mixed crude drug extract, 1,000 to 5,000 mL of the mixed crude drug extract of step (A1) was concentrated to 500 to 1,000 mL by vacuum low-temperature concentration method to prepare a concentrated herbal concentrate.

(B1) 10.0% by weight of pine kernel, 9.5% by weight of gold, 5.0% by weight of raw paper, 5.0% by weight of ginseng, 9.5% by weight of yogurt, 10.0% by weight of acidophore, 5.0% 4.5% by weight of the herbal medicine was thoroughly washed and dried in a drier at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare 100 to 400 mesh mixed herbal powder.

(C1) a granulating agent is prepared by lyophilization after mixing the concentrated herbicidal concentrate of step (A2) and corn powder (excipient) at a weight ratio of 2: 1, and the concentrate of the mixed herbicide of step (A2) Were mixed at a weight ratio of 2: 1 and dried at a temperature of 65 to 75 ° C for 8 to 10 hours to prepare a 200-mesh powder. To 300 g of the powder was added 300 g of glutinous rice and 1,000 ml of purified water The pellet was then made with a diameter of 5 mm.

< Comparative Example  >  Comparison of anti-depressant and therapeutic compositions Manufacturing example

The comparative preparation examples of the composition for preventing and treating depression of the present invention are those of the prior art and are prepared by mixing with the following composition contents.

250 g of bokbunja was added and extracted three times with 70% methanol (750 mL) using an ultrasonic device to prepare a mixed herbal medicine extract.

< Test Example  >

In order to confirm the effect of the method for the preparation of a composition for the prevention and treatment of depression using the mixed herbal medicine extract of the present invention as an active ingredient, the mixed herbal medicine extract prepared by <Examples 1 to 5 and <Comparative Example> (50 men and 25 women) with insomnia, loss of appetite, loss of concentration due to depression. Sensory evaluation of sleep improvement, appetite improvement, and concentration improvement was conducted by a 5-point scale survey. Very good 5 points, good 4 points, average 3 points, poor 2 points, and very poor 1 point. The evaluation scores are shown in Table 1 below.

Evaluation items Example 1
extract Example 2
extract Example 3
extract Example 4
extract Example 5
extract Comparative example
extract Sleep improvement 4.24 4.85 4.75 4.41 4.96 2.37 Improve appetite 4.10 4.73 4.53 4.34 4.83 2.43 Improve concentration 4.05 4.68 4.30 4.27 4.77 2.15

As described above, the present invention is not limited to the above-described embodiments, but is merely an example of a composition for preventing and treating depression, which comprises an extract of a mixed herbal medicine as an active ingredient. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the appended claims and their equivalents. .

Claims (10)

Which comprises extracting a crude herbal medicine extract, which is extracted from a mixed herbal medicine comprising prawn, pork, golden, and raw papaya, as an active ingredient. The method according to claim 1,
The composition for preventing and treating depression according to claim 1, wherein the composition is an extract of a mixed herbal medicine extracted from a mixed herbal medicine which further comprises the raw milk, golden, and raw ginseng. The method according to claim 1,
The composition for preventing and treating depression as claimed in claim 1, wherein the composition is a mixture of crude herbal medicine extracts extracted from a mixed herbal medicine comprising pomegranate, golden, and raw poultry. The method according to claim 1,
The composition for preventing and treating depression according to claim 1, wherein the composition comprises a crude herbal medicine extract, which is extracted from a mixed herbal medicine which further comprises ginseng root, omija, and ginger. The method according to claim 1,
The present invention relates to a method for preventing and treating depression comprising administering an extract of a mixed herbal medicine extracted from a mixed herbal medicine extract made of a mixture of herbaceous ginseng, golden ginseng, Chinese ginseng, dried ginseng, Therapeutic composition. (A1) extracting the mixed herbal medicine extract from the mixed herbal medicine;
(A2) of concentrating the crude herbal medicine extract of step (A1) to prepare a concentrated herbal concentrate;
(B1) of drying and pulverizing the mixed herbicide to prepare a mixed herbicidal powder;
(C1) mixing granular herbicide concentrate of step (A2) and mixed herbal powder of step (B1) to prepare granules, powders and pills,
Wherein the mixed herbicide of step (A1) and step (B1) is composed of any one or more of the mixed herbicides of claims 1 to 5. 12. A method for the preparation of a composition for preventing and treating depression, The method according to claim 6,
Wherein the extract solvent is a mixture of purified water and a food alcohol at a weight ratio of 8: 2 to 5: 5 at a step (A1) for extracting the mixed herbal medicine extract. &Lt; / RTI &gt; The method according to claim 6,
A composition for preventing and treating depression comprising an active ingredient of a mixed herbal medicine extract, wherein the granular herb preparation is prepared by blending the concentrated herbal concentrate of step (A2) and corn powder at a weight ratio of 1: 1 to 4: 1 Gt; The method according to claim 6,
Wherein the mixed concentrate of step (A2) is mixed with the mixed herbicidal powder of step (B1) and dried at a temperature of 65 to 75 ° C to prepare a powder. &Lt; / RTI &gt; 10. The method of claim 9,
The method of manufacturing a preventive and therapeutic composition for depression according to claim 1, wherein the powder is further mixed with glutinous rice and purified water, and then the pills are manufactured to a diameter of 3 to 7 mm.

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