KR20160150473A

KR20160150473A - Cosmetic composition containing non-toxic sulfur for sikn moisture, anti-inflammatory and immune enhancement and manufacturing the same

Info

Publication number: KR20160150473A
Application number: KR1020150088524A
Authority: KR
Inventors: 이지영; 김우열
Original assignee: 이지영; 김우열
Priority date: 2015-06-22
Filing date: 2015-06-22
Publication date: 2016-12-30
Also published as: KR101761005B1

Abstract

The present invention relates to a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement comprising a nanoliposome, and a method of preparing the same, wherein the nanoliposome comprises legal sulfur and water-soluble beta-glucan, The sulfur is pulverized into nano-sized particles and the nano-sized legal sulfur is liposomized with water-soluble beta-glucan to increase skin penetration and absorption rate, increase skin moisturizing effect, increase sulfur absorption effect, An effect of reinforcement is generated.

Description

TECHNICAL FIELD The present invention relates to cosmetic compositions for skin moisturization, anti-inflammation and immunity enhancement,

The present invention relates to a cosmetic composition for skin moisturizing, anti-inflammation, and immunity enhancement containing legal sulfur, and a method for preparing the same, which comprises subjecting leguminous sulfur removed from toxicity to nano-size and treating liposomal nano- To a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement, which has enhanced skin penetration and absorption rate.

The absorption pathway through the skin has three pathways: absorption through the stratum corneum, absorption through the hair follicle and sebaceous gland, and absorption through the eccrine gland. To date, absorption through the stratum corneum is the most important In the absorption pathway, the horny layer is composed of nonpolar lipids because the keratinocyte gap is almost absent in the polar material, and only the lipophilic material can be absorbed.

Polar substances are bound to proteins in the cytoplasm or interstices by hydrogen bonding and are not absorbed through the skin. On the other hand, nonpolar materials are mainly dissolved in cell spaces and pass through skin barrier. However, even if it passes through the stratum corneum, the solubility in the lower part of the stratum corneum is small, and it is inhibited from being absorbed by the whole body by the mechanism of various metabolism-causing enzymes and elimination of keratinocytes. With this principle, the stratum corneum protects the human body from numerous external polar substances, but nonpolar toxicants can also be absorbed into the stratum corneum.

The greatest barrier to transdermal absorption is the keratinocytes in the stratum corneum and the interstitial cells between them. Since most of the active ingredients have low transdermal permeability due to the resistance of the horny layer of the skin, various methods are needed to overcome them and to enhance permeation of the active ingredient. Mixing of lipophilic substances with ethanol, propylene glycol, surfactants, fatty acids and the like is a very effective method for transdermal delivery of the components at the required rate and effective concentration. Also, as disclosed in Korean Patent Laid-Open No. 10-2005-0055114, transdermal delivery of an active ingredient using a liposome made of lecithin or intercellular lipid components is a much more effective transdermal absorption method.

Sulfur is a non-metallic element represented by the symbol S and has an atomic number of 16 and an atomic weight of 32.06. The melting point is 120 ° C. and the specific gravity is 1.92. Sulfur is a yellow crystal at room temperature and reacts with almost all metals and hydrogen except gold and platinum to form sulfides. According to Dongbu Bohak's hot water solution, 'sulfur is rusty, flavorful and poisonous. The symptoms of cold or swelling of the lumps or waist underneath the mandible, symptoms without any sensation due to cold winds, and poor circulation and poor leg strength and weakness. In addition, it strengthens tendons and bones, strengthens sexual function, kills hair loss, inflammation of skin, inflammation around genital area, and kills insects that cause numbness and swelling. "From ancient times, eczema, skin pruritus It is known to be effective in treating chronic dermatitis. However, due to the toxic nature of sulfur, it can cause abdominal pain and diarrhea when taking it, which can aggravate skin inflammation or cause hair loss. Accordingly, studies on a method of efficiently increasing the penetration and absorption rate into the body while removing toxic components of sulfur have been actively conducted.

It is an object of the present invention to provide a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement containing legal sulfur and a process for producing the same.

Another object of the present invention is to provide a cosmetic composition for skin moisturizing, anti-inflammation, and immunity enhancement, which is obtained by liposomalizing legally prescribed sulfur with water-soluble beta-glucan and enhancing skin penetration and absorption rate, and a process for producing the same.

In one embodiment of the present invention, a cosmetic composition for anti-inflammation and immunity enhancement comprising a nanoliposome, wherein the nanoliposome comprises a volatile sulfur and a water-soluble beta-glucan, wherein the sulfur-containing sulfur has a particle size of 20 to 80 nm, And to a cosmetic composition for anti-inflammation and immunity enhancement.

In one embodiment of the present invention, the legal sulfur is a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement having a particle size of 30 to 60 nm.

In one embodiment of the present invention, the cosmetic composition comprises 0.2 to 10% by weight of sulfur, 0.1 to 15% by weight of water-soluble betaglucan, 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of vegetable chlorella, 0.01 to 5% , 70 to 78 wt% of distilled water, and the rest of the cosmetic base, and to a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement.

In one embodiment of the present invention, the cosmetic composition comprises 0.5 to 5% by weight of sulfur, 0.1 to 10% by weight of water-soluble betaglucan, 0.01 to 0.5% by weight of natural minerals, 0.5 to 2% by weight of vegetable chlorella, 0.01 to 1% , 72 to 77 wt% of distilled water, and the rest of the cosmetic base. The present invention also relates to a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement.

In one embodiment of the present invention, 1) a process for pulverizing a process sulfur; 2) mixing nano-liposome-forming sulfur and beta-glucan in the step 1) and drying the nano-liposome to form a nanoliposome-forming sulfur; 3) mixing the additive with the nanoliposome-formed sulfur of step 2) to prepare a mixture; And 4) stirring the mixture of step 3). The present invention also relates to a method for producing a cosmetic composition for skin moisturizing, anti-inflammation and immunity.

In one embodiment of the present invention, the additive of step 3) relates to a method for preparing a skin moisturizing, anti-inflammatory and immunological cosmetic composition which is distilled water, natural minerals, vegetable chlorella, nem oil and other cosmetic bases.

In one embodiment of the present invention, the additive of step 3) comprises 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of vegetable chlorella, 0.01 to 5% by weight of nematic oil, 70 to 78% by weight of distilled water, And to a method for producing a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention and claims.

The embodiments of the present invention are described in order to more fully explain the present invention to those skilled in the art, and the following embodiments may be modified into various other forms, The present invention is not limited to the embodiment. Rather, these embodiments are provided so that this disclosure will be more faithful and complete, and will fully convey the scope of the invention to those skilled in the art.

In the drawings, the thickness and size of each layer are exaggerated for convenience and clarity of description, and the same reference numerals refer to the same elements in the drawings. As used herein, the term "and / or" includes any and all combinations of one or more of the listed items.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a," "an," and "the" include singular forms unless the context clearly dictates otherwise. Also, " comprise "and / or" comprising "when used herein should be interpreted as specifying the presence of stated shapes, numbers, steps, operations, elements, elements, and / And does not preclude the presence or addition of one or more other features, integers, operations, elements, elements, and / or groups.

In the present invention, the term "legal process" means "a process in which a certain substance is subjected to a certain process for writing or medicinal use or for changing properties", and "legal process sulfur" means a process in which a toxic component contained in sulfur is removed It means sulfur.

In the present invention, beta-glucan is a kind of polysaccharide, which has immune enhancing activity and is present in cell walls, mushrooms, cereals and the like of yeast. Beta Glucan is a glucose polymer having a basic structure of β-glycosidic bonds at positions 1 and 3 of the glucose unit, and its structure and physicochemical properties are different depending on the position where glucose is bonded.

In the present invention, liposomes are lipid vesicles (artificial membranes). It can be used as a microcapsule for administering medical products because it can reproduce various actions by enclosing various substances in liposomes or reconstructing membrane proteins in membranes like biological membranes.

In an embodiment of the present invention, in a cosmetic composition for anti-inflammation and immunity enhancement comprising a nanoliposome, the nanoliposome includes legal sulfur and water-soluble beta-glucan, and the legal sulfur is a skin moisturizing agent having a particle size of 20 to 80 nm, And to a cosmetic composition for anti-inflammation and immunity enhancement. The legal sulfur preferably has a particle size of 20 to 80 nm, more preferably 30 to 60 nm, and most preferably 40 nm. If the particle size of the legal sulfur is less than 20 nm, the problem may occur that the sulfur is absorbed in the body before the sulfur is applied to the skin after being administered and absorbed into the body. When the particle size exceeds 80 nm, Is difficult to absorb.

In one embodiment of the present invention, the cosmetic composition comprises 0.2 to 10% by weight of legal sulfur, 0.1 to 15% by weight of water-soluble betaglucan, 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of vegetable chlorella, 0.01 to 5% % Of distilled water, 70 to 78 wt% of distilled water, and the rest of the cosmetic base, preferably 0.5 to 5 wt% of legal sulfur, 0.1 to 10 wt% of water-soluble beta glucan, 0.01 to 0.5 wt% of natural minerals, 0.01 to 1% by weight of nematic oil, 72 to 77% by weight of distilled water, and the rest of the cosmetic base.

Chlorella is a green algae of green algae. It is abundant in proteins and has excellent photosynthetic efficiency, and is well received as a food for the future. Chlorella has the effect of improving immunity and preventing aging. When the chlorella content is less than 0.5% by weight, the above-mentioned effect is insufficient. When the chlorella content is more than 5% by weight, there is a problem in that the cost benefit is not large.

The natural minerals are one of the five essential nutrients (fat, protein, carbohydrate, vitamins, and minerals) necessary for the body. It has 150,000 biochemical and electrical activities such as nerve stimulation and muscle contraction in the body. And antioxidant activity, immunity, removal of active oxygen, removal of heavy metals, and removal of chemicals. When the natural minerals are contained in an amount of less than 0.01% by weight, the above-mentioned effects are insufficient. When the amount of the natural minerals is more than 1% by weight, the benefits of the natural minerals are not large.

The nem oil refers to extracted and purified from nuts tree nuts. It is used as a liver drug in Japan, acupuncture control and dressing in China, and needle control and blood pressure enhancer in the United States. The nematic oil improves the bactericidal effect. When the nematic oil is contained in an amount of less than 0.01% by weight, the sterilizing effect is insufficient. When the nematic oil is more than 5% by weight, the benefit of the cost is not great.

The above-mentioned sulfur means that the toxic component of sulfur has been removed, and means the legal sulfur produced in accordance with Korean Patent No. 10-1376330. The legal sulfur has the effects of pain relief, inflammation removal, transport of effective substances, cell regeneration, blood circulation promotion, detoxification and sterilization. When the legal sulfur content is less than 0.2% by weight, If the weight percentages are exceeded, there is a problem in that the profit for the cost is not large.

The above-mentioned sulfur is converted into liposomes by beta-glucan, and the physiological activity and the penetration into the body are further improved. The size of the legal sulfur particles is 20 to 80 nm. When liposomes are used, the thickness increases by several to several tens of nanometers by beta-glucan. When the size of the legal sulfur particles exceeds 80 nm, It is difficult to penetrate.

The beta-glucan is a polysaccharide of a D-glucose monomer linked by beta-glycosidic linkage. The structure of beta-glucan is shown below.

&Lt; Formula 1 >

The beta-glucan can be extracted by pressurized hot water extraction (PHWE) method. Specifically, the dried mushroom powder and distilled water are filled in a batch reactor and reacted at 150 to 180 ° C for 10 minutes at 50 to 180 ° C to extract . But is not limited to beta-glucan extracted by the above extraction method. 0.1 to 15% by weight of the water-soluble beta-glucan is contained. When the content of the water-soluble beta-glucan is less than 0.1% by weight, formation of liposomes on the surface of the legal sulfur is difficult. When the content exceeds 15% by weight, And beta-glucan, which is still remaining after the formation of liposomes.

The other cosmetic base may be selected from the group consisting of lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, chlorofluorohydrocarbons, propane / butane, dimethyl ether, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, A fatty acid amide ether sulfate, an alkylamidobetaine, an aliphatic alcohol, a fatty acid glyceride, a fatty acid diethanolamide, a vegetable oil, a lanolin derivative, a fatty acid amide ether sulfate, Aspirin, threonine, serine, glutamic acid, proline, glycine, alanine, lysine, histidine, Valine, methionine or ethoxylated glycerol fatty acid esters, and the like And is not limited to the examples.

In one embodiment of the present invention, 1) a process for pulverizing a process sulfur sulfur pulverization step (SlOO); 2) a nanoliposome-forming step (S200) for preparing a nanoliposome-formed sulfur by mixing the pulverized sulfur of step 1) with beta-glucan and drying; 3) preparing an admixture by adding an additive to the nanoliposome-formed sulfur of step 2) (S300); And 4) stirring step (S400) of stirring the mixture of the step 3). The present invention also relates to a method for producing a cosmetic composition for skin moisturizing, anti-inflammation and immunity.

The legal sulfur pulverization step (S100) is a legal sulfur produced according to Korean Patent No. 10-1376330, which is nanoized through a milling apparatus filled with a nano-liquid ball mill. The nanoized legal sulfur has a particle size of 20 to 80 nm, preferably 30 to 60 nm, and more preferably 40 nm. 2 and 3 are data obtained by measuring the size of the nanoized legal sulfur. According to the result data, the size of the legal sulfur particles is distributed in the range of 20 to 80 nm.

The nano-liposome forming step (S200) is a step of preparing a nano-liposome-formed sulfur by mixing legume sulfur and beta-glucan. After the legal sulfur and the beta-glucan are added to the agitator, the agitated mixture is stirred at a speed of 150 to 250 rpm for 5 to 30 minutes, then the agitated mixture is put into a drier and dried at a temperature of 70 to 90 ° C for 10 to 20 minutes. Through the above drying process, water contained in the legal sulfur can be removed, and sulfurized with beta glucan can be produced. As mentioned above, the leguminous sulfur liposomalized with beta-glucan is improved in penetration and moisture absorption rate in the body due to beta-glucan.

In step S300 of mixing the additives, the additive is mixed with the nanoliposome formed through the nanoliposome formation step (S200). The additive in step 3) may be added in an amount of 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of chlorella, 0.01 to 5% by weight of nematic oil, 70 to 78% by weight of distilled water, and the rest of the cosmetic base. The other cosmetic base may be selected from the group consisting of lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder, chlorofluorohydrocarbons, propane / butane, dimethyl ether, aliphatic alcohol sulfates, aliphatic alcohol ether sulfates, A fatty acid amide ether sulfate, an alkylamidobetaine, an aliphatic alcohol, a fatty acid glyceride, a fatty acid diethanolamide, a vegetable oil, a lanolin derivative, a fatty acid amide ether sulfate, Aspirin, threonine, serine, glutamic acid, proline, glycine, alanine, lysine, histidine, Valine, methionine or ethoxylated glycerol fatty acid esters, and the like And is not limited to the examples.

The stirring step S400 is a step of mixing the additive with the additive through a step S300 of mixing the additive. The additive mixture is stirred at a rate of 150 to 250 rpm for 10 to 20 minutes Lt; / RTI > to homogenize the mixture.

After the agitation step (S500), the nanoliposome according to the present invention is formed to produce a cosmetic composition for skin moisturizing, anti-inflammation, and immunity enhancement.

The cosmetic composition of the present invention may be prepared in any of the formulations conventionally produced in the art and may be in the form of a solution, a suspension, a paste, a gel, a cream, a lotion, a powder, a soap, a surfactant- A powder foundation, an emulsion foundation, a wax foundation, a bath agent, and a spray, but the present invention is not limited thereto. More specifically, it can be prepared in the form of a soft lotion, a nutritional lotion, a nutritional cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, a bath, a body cleanser or a powder.

When the formulation of the present invention is a paste, a cream or a gel, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In particular, in the case of a spray, a mixture of chlorofluorohydrocarbons, Propane / butane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

The present invention relates to a cosmetic composition for skin moisturizing, anti-inflammation and immunity enhancement comprising a nanoliposome and a method of preparing the same, wherein the nanoliposome comprises legal sulfur having a particle size of nanosize and water-soluble beta-glucan, Increase the absorption rate, increase the skin moisturizing effect, increase the skin anti-inflammatory effect by transferring sulfur directly into the body, and produce the effect of enhancing the immunity.

1 is a flowchart showing a method for preparing a cosmetic composition for anti-inflammation and immunity according to an embodiment of the present invention.
Fig. 2 shows the result of measurement of the size of the nanoized legal sulfur.
Fig. 3 shows the result of measurement of the size of the nano-sized legal sulfur.
FIG. 4 is a photograph showing the effect of wound healing after using a bathing agent containing a cosmetic composition prepared according to one embodiment of the present invention for a patient suffering from hemorrhoids.
FIG. 5 is a photograph showing skin inflammation and immunity enhancement using a body crawler including a cosmetic composition prepared according to one embodiment of the present invention.
Fig. 6 is a photograph of the particle state of a liquid phase sulfur state before pulverization through a milling apparatus. Fig.
FIG. 7 is a photograph of particles of legal sulfur after being milled through a milling apparatus for 1 hour.
FIG. 8 is a photograph of particles of legal sulfur after being milled through a milling apparatus for 2 hours.
Fig. 9 is a photograph of the particles of the legal sulfur after being milled through a milling apparatus for 3 hours. Fig.

Hereinafter, the specific structure and function of the present invention will be described in more detail with reference to Examples and Experimental Examples. However, the following examples and experimental examples are only illustrative of the present invention, but are not limited thereto.

FIG. 1 is a flowchart illustrating a method for preparing a cosmetic composition for anti-inflammation and immunity according to an embodiment of the present invention. Referring to FIG. 1) Method for crushing legal sulfur Sulfur crushing step (S100); 2) a nanoliposome-forming step (S200) for preparing a nanoliposome-formed sulfur by mixing the pulverized sulfur of step 1) with beta-glucan and drying; 3) preparing an admixture by adding an additive to the nanoliposome-formed sulfur of step 2) (S300); And 4) stirring step (S400) of stirring the mixture of step 3).

The legal sulfur used in the present invention is the sulfur produced by the Korean Registered Patent No. 10-1376330, from which toxin components have been removed from the sulfur. The pulverization step in the step 1) is carried out through a milling apparatus filled with a nano-liquid ball mill. For nanogenesis, nanoparticles are prepared by non-mechanical pulverization methods such as evaporation-condensation method, gas phase synthesis method, spray pyrolysis method and the like. In the evaporative condensation method, a starting material is hydrolyzed or subjected to a condensation / condensation reaction to form a sol compound in which colloidal particles having a size of 1 μm or less are dispersed, and then a gel having a network structure is formed. To obtain nanoparticles of the required size. The vapor phase synthesis method is a method of obtaining nanoparticles directly from volatile metal chlorides or the like using a chemical reaction. In the spray pyrolysis method, water is removed in an aqueous solution in which a metal salt is dissolved by using a spray dryer to prepare a fine metal salt powder, and then the powder of the metal salt is treated to prepare a nano-sized powder. However, this process uses a ball milling device which can obtain nanoparticles of a certain size, which is simple in that the manufacturing process itself is complicated and uses various complicated equipments used in complicated processes.

In an embodiment of the present invention, FIGS. 6 to 9 are photographs of particles when sulfur is nanoized through a milling apparatus filled with a nano-liquid ball mill. Fig. 6 is a photograph of the particle state of a liquid phase sulfur state before pulverization through a milling apparatus. Fig. FIG. 7 is a photograph of particles of the legal sulfur after the milling for 1 hour through a milling machine, FIG. 8 is a photograph of the particles of the legal sulfur after milling for 2 hours through a milling machine, and FIG. Lt; RTI ID = 0.0 > milligrams < / RTI > for a period of time. The sulfur in the liquid phase state of Fig. 6 has uneven particle size, and particles having a large size are difficult to penetrate into the body even when used as a cosmetic composition. However, when pulverizing using a milling apparatus, the size of the legal sulfur particles is maintained even over time, and generally 20 to 80 nm as in FIGS. 2 to 3, and penetration into the body is easy.

The milling device filled with the ball mill is a device used when a very fine powder is required. It can generate a high grinding energy at a short grinding time by using a very high centrifugal force of the ball mill. Through such grinding energy, The impact can nanoize the legal sulfur. When the liquid sulfur is milled through a milling device filled with a ball mill, it is possible to produce more naturally formulated sulfur particles as the milling time elapses.

Hereinafter, the method and properties of a cosmetic composition for anti-inflammation and immunity enhancement comprising nanoliposome formed by the legal sulfur and water-soluble beta-glucan according to the present invention will be described with reference to examples.

[Example 1]

Legal sulfur and nano formed by water-soluble beta-glucan Liposomes Preparation of Cosmetic Composition for Anti-inflammation and Immunity Containing

[Production Example 1]

The legal sulfur was nanoized to a particle size of 40 nm through a milling device filled with a nano-liquid ball mill.

5% by weight of the above-mentioned nano-formaldehyde sulfur and 10% by weight of water-soluble beta-glucan were put into a stirrer and stirred at a speed of 200 rpm for 15 minutes. Thereafter, the stirred mixture was put into a drier and dried at 80 ° C for 15 minutes Beta-glucan was prepared and 0.5% by weight of natural minerals, 2.0% by weight of vegetable chlorella, 1% by weight of nematic oil, 77% by weight of distilled water and 4.5% of cosmetic base were added to the legal sulfur in which the liposome was formed, . Specifically, the cosmetic base comprises 0.5% by weight of polysorbate 60, 0.5% by weight of glycol stearate, 0.5% by weight of stearic acid, 0.5% by weight of cetearyl alcohol, 0.5% by weight of petrolatum, 0.5% 0.1% by weight of arginine, 0.1% by weight of fragrance, 0.1% by weight of betaine, 0.1% by weight of panthenol, 0.1% by weight of isopropyl myristate and 1% by weight of phenoxyethanol.

[Comparative Example 1]

The procedure was carried out in the same manner as in Production Example 1, except that the legal sulfur was nano-sized to a particle size of 10 nm through a milling device filled with a nano-liquid-phase ball mill.

[Comparative Example 2]

The procedure was the same as that of Preparation Example 1, except that the legal sulfur was nano-sized to a particle size of 90 nm through a milling apparatus filled with a nano-liquid ball mill.

[Comparative Example 3]

To prepare a cosmetic composition comprising glycerin and sorbitol known to be effective for moisturizing the skin, 7.5% by weight of glycerin and 7.5% by weight of sorbitol were added.

[Comparative Example 4]

In order to prepare a cosmetic composition containing nano-structured process sulfur without liposome formation, the preparation was carried out in the same manner as in Preparation Example 1, except that 87% by weight of distilled water was added instead of water-soluble beta-glucan.

[Example 2]

1. Measurement of skin moisturizing effect

Each of the cosmetic preparations prepared in Preparation Example 1 and Comparative Examples 1 to 4 was applied for 20 days, twice a day for 4 weeks. The results of the questionnaire were as follows: satisfaction with the degree of skin dryness improvement was classified into excellent, good, normal, and insufficient. The results are shown in Table 1 below.

Very good Good usually Inadequate Production Example 1 6 10 3 One Comparative Example 1 3 5 9 3 Comparative Example 2 3 4 8 5 Comparative Example 3 4 8 6 2 Comparative Example 4 2 5 11 2

As can be seen from the results shown in Table 1, the number of persons indicated as good or better in Manufacturing Example 1 is 16, the number of people in Comparative Example 1 is 8, the number of people in Comparative Example 2 is 7, the number of people in Comparative Example 3 is 12, Was 7, indicating that the skin dryness improvement effect was excellent when the cosmetic preparation prepared in Preparation Example 1 was used as compared with Comparative Examples 1 to 4. According to Preparation Example 1 and Comparative Example 3, a cosmetic composition containing liposomized legal sulfur is superior to the cosmetic composition containing glycerin and sorbitol, which is generally known to be effective for skin moisturizing, and has excellent skin moisturizing effect. In addition, as shown in Comparative Example 4, even when the legal sulfur was nanoized, it was confirmed that the skin penetration and absorption power was poor and the skin moisturizing effect did not show good when liposomized. As a result, the cosmetic preparation produced by Preparation Example 1 is superior in skin moisturizing effect as compared with Comparative Examples 1 to 4.

2. Measurement of Anti-inflammatory and Immune Enhancement Effects

The result of using the bath preparation containing the cosmetic preparation prepared in Preparation Example 1 for 3 weeks in a patient who underwent hemorrhoid surgery is shown in FIG. In general, it takes 6 to 8 weeks to complete recovery after hemorrhoid surgery. However, the bath preparation prepared in Preparation Example 2 was continuously used for the hemorrhoid surgery patients, and it was confirmed whether it was cured after 1 week and 3 weeks. After 1 week of use compared to before bathing, the site of the surgery was recovered and after 3 weeks, the site of surgery was completely recovered.

In addition, the body clanger including the cosmetic preparation prepared in Preparation Example 1 was continuously used in patients having skin inflammation, and the inflammation site was observed after one week and two weeks, and the results are shown in FIG. After the first week, only the red irritation remained. The remaining black irritation disappeared. After 2 weeks, only the fine red irritation remained It can be confirmed that it has recovered.

A cosmetic composition for skin moisturizing, anti-inflammation, and immunity enhancement comprising a nanoliposome formed by a legal sulfur and a water-soluble beta-glucan having a particle size of nanosize through a bathing agent and a body clanger containing the cosmetic preparation prepared in Preparation Example 1 Has excellent penetration and absorption power in the body, enhances skin moisturizing effect, suppresses inflammation of skin and suppresses the occurrence of skin, and has an effect of enhancing skin immunity.

Claims

A cosmetic composition for anti-inflammation and immunity, comprising a nanoliposome,
Nano liposomes include legal sulfur and water-soluble beta-glucans,
The cosmetic composition for skin moisturizing, anti-inflammation and immunostaining has a particle size of 20 to 80 nm.

The method according to claim 1,
The cosmetic composition for skin moisturizing, anti-inflammation and immunostaining has a particle size of 30 to 60 nm.

The method according to claim 1,
The cosmetic composition according to claim 1, wherein the cosmetic composition comprises 0.2 to 10% by weight of sulfur, 0.1 to 15% by weight of water-soluble beta-glucan, 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of vegetable chlorella, 0.01 to 5% % &Lt; / RTI > and the rest of the cosmetic base for skin moisturization, anti-inflammation and immunity enhancement.

The method of claim 3,
The cosmetic composition according to claim 1, wherein the cosmetic composition comprises 0.5 to 5% by weight of sulfur, 0.1 to 10% by weight of water-soluble beta-glucan, 0.01 to 0.5% by weight of natural minerals, 0.5 to 2% by weight of vegetable chlorella, 0.01 to 1% % &Lt; / RTI > and the rest of the cosmetic base for skin moisturization, anti-inflammation and immunity enhancement.

1) Process Method for crushing sulfur sulfur crushing step;
2) mixing nano-liposome-forming sulfur and beta-glucan in the step 1) and drying the nano-liposome to form a nanoliposome-forming sulfur;
3) mixing the additive with the nanoliposome-formed sulfur of step 2) to prepare a mixture; And
And 4) stirring the mixture of step 3). The method of manufacturing a cosmetic composition for skin moisturizing, anti-inflammation and immunization.

6. The method of claim 5,
The method for producing a cosmetic composition for skin moisturizing, anti-inflammation, and immunity, wherein the pulverized process sulfur in step 2) has a particle size of 20 to 80 nm.

6. The method of claim 5,
Wherein the additive of step 3) is a base of distilled water, natural minerals, vegetable chlorella, nem oil and other cosmetics.

6. The method of claim 5,
The additive of step 3) may be selected from the group consisting of skin moisturizing, anti-inflammatory and anti-inflammatory agents comprising 0.01 to 1% by weight of natural minerals, 0.5 to 5% by weight of vegetable chlorella, 0.01 to 5% by weight of nematic oil, 70 to 78% by weight of distilled water, A method for producing a cosmetic composition for enhancing immunity.