KR20160117073A - Hair and/or scalp composition - Google Patents

Abstract

The present invention relates to a composition of a hair, which does not contain a mixed solution of methylchloroisothiazolinone and methylisothiazolinone and, more specifically, relates to a composition for a hair, which does not contain a mixed solution of methylchloroisothiazolinone and methylisothiazolinone and exhibits excellent preservativeness, by using sodium benzoate, cetrimonium chloride, and steartrimonium chloride together.

Description

[0001] Hair and / or scalp composition [0002]

The present invention relates to a composition for hair and / or scalp which does not contain a mixture of methylchloroisothiazolinone and methylisothiazolinone, and more particularly to a composition for hair and / or scalp which comprises sodium benzoate, settimoronium chloride and stearothermolinium chloride And a composition for hair and / or scalp which does not contain a mixture of methylchloroisothiazolinone and methylisothiazolinone and exhibits excellent repellency when used together.

The composition for external application for skin may be contaminated with microorganisms through various routes such as contamination by microorganisms that may occur during the production process, contamination of microorganisms by skin contact of fingers during use, or contamination by water during use. Therefore, mixing of preservatives and the like is required to inhibit or kill the growth of microorganisms in the composition and to improve the shelf life of the product.

Examples of commonly used preservatives include, for example, paraoxybenzoic acid esters (commonly referred to as " parabens "), imidazolidinyl urea, phenoxyethanol or chlorophenesin, and in particular shampoos, BACKGROUND OF THE INVENTION [0002] Isothiazolinone-based compounds such as methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) are widely used in various life chemical products. These chemical preservatives may exhibit effectiveness as a preservative means for use in the composition for external application for skin. However, these chemical preservatives incorporated into the composition may exhibit skin irritation, allergies and the like, and may even exhibit skin toxicity in severe cases.

Methylchloroisothiazolinone and methylisothiazolinone are generally used as a mixture of methylchloroisothiazolinone and methylisothiazolinone mixed solution rather than being used alone. The growth of bacteria, yeast and fungi It has been used for sterilization, disinfection, and disinfection. However, if it enters the respiratory tract, it may not have a bad influence on the human body. Also, if the concentration is high, it may cause burns on the skin due to chemicals, It is currently used in small quantities in detergents such as shampoos, or in most adhesives, detergents, paints, fuels and other industrial processes.

As described above, conventional preservatives such as parabens, phenoxyethanol, isothiazolinone and the like can provide an effective preservative or germicidal effect by using an appropriate amount, but these compounds are highly irritating and have bad effects on the human body , There is a need for a substance that can replace it.

Korea Patent Publication No. 2012-0054663

Accordingly, the present inventors have sought to find a substitute for parabens, phenoxyethanol, and isothiazolinone compounds, which are commonly used in hair and / or scalp compositions, and have found that sodium benzoate can be used in combination with settimonium chloride It has been found that when used in combination with rimonium chloride, it can exhibit excellent repellency, thereby completing the present invention.

Accordingly, the present invention is to provide a composition for hair and / or scalp that does not contain a preservative that is strong in the prior art and exhibits excellent repellency.

In order to accomplish the above object, the present invention provides a preservative composition for hair and / or scalp containing sodium benzoate, settimonium chloride and stearatrimonium chloride as an active ingredient.

The composition for hair and / or scalp of the present invention can be prepared by using sodium benzoate in combination with settimonium chloride and stearothermonium chloride in place of conventional preservatives such as phenoxyethanol and isothiazolinone compounds, It is possible to avoid the danger and problem caused by the use of the preservative, while maintaining excellent buoyancy and antibacterial activity.

The present invention relates to a preservative composition for hair and / or scalp that does not contain conventional preservatives such as parabens, phenoxyethanol, and isothiazolinone compounds. More specifically, the present invention includes sodium benzoate, settimonium chloride, and stearothermonium chloride as preservatives in place of conventional preservatives.

In the composition of the present invention, sodium benzoate is added in an amount of 0.01 to 2.0% by weight, preferably 0.1 to 1.0% by weight, more preferably 0.3 to 0.7% by weight, most preferably 0.5% by weight .

In the composition of the present invention, the settimonium chloride is used in an amount of 0.01 to 3.0 wt%, preferably 0.5 to 2.0 wt%, more preferably 1.0 to 1.5 wt%, and most preferably 1.2 wt% .

In the composition of the present invention, the stearothermolinium chloride is added in an amount of 0.001 to 1.5% by weight, preferably 0.01 to 1.0% by weight, more preferably 0.1 to 0.5% by weight, most preferably 0.3 % ≪ / RTI > by weight.

The composition according to the present invention may further contain pigments, preservatives, sequestering agents or fragrances which are conventionally used in the art within the range of maintaining stability.

The present invention also provides a composition for hair and / or scalp comprising the above-mentioned preservative composition for hair and / or scalp.

The composition for hair and / or scalp of the present invention is not particularly limited in its formulation, and specific examples thereof include shampoo, rinse, hair treatment, hair tonic, hair nutrition lotion, scalp treatment, hair lotion, scalp essence, A hair-scalp-type treatment, and the like, and can be preferably formulated into a hair-cleansing composition. The composition for hair and / or scalp of each of these formulations may contain various components that are formulated in a conventional hair composition according to the various formulations described above or for the final purpose, and the kind and amount of these components may be readily Can be selected.

Hereinafter, the present invention will be described in more detail by way of examples and test examples, but the present invention is not limited thereto.

[Test Example 1] Evaluation of minimum inhibitory concentration (MIC)

Escherichia coli (ATCC 8739); E), Pseudomonas aeruginosa (ATCC 9027); P), Staphylococcus aureus (ATCC 6538; S), Candida albicans (ATCC 10231 (Tryptic Soy Broth (Difco) or SDB (Sabouraud Dextrose Broth; Difco)) suitable for each strain of Aspergillus brassiliensis (C) (yeast), and Aspergillus brasiliensis (ATCC 16404) ), Shake-cultured at 32 ° C for 1 day, and the diluted solution diluted 1/100 with the culture medium was used as the test strain. Candida albicans used a 1/10 diluted dilution as the test bacterium, and Aspergillus brassiensis used a previously prepared spore suspension.

A suspension in which the substances shown in the following Table 1 were suspended in TSB or SDB medium at an appropriate concentration was used as a sample.

200 μl of sample dilution was added to the 96 well plate 1 row. 100 μl of the appropriate medium was added to the remaining wells.

The mixed solution of row 1 was mixed well, and 100 μl was taken and placed in row 2, mixed well, and 100 μl was taken again and placed in row 3 to perform double dilution.

After culturing at 32 ° C for 24 hours (yeast and fungi cultured at 22.5 ° C for 72 hours), the presence or absence of bacterial growth was determined to the extent of suspension, and the minimum concentration without bacterial growth was determined as the MIC value. If the mixture is opaque and it is difficult to judge the growth of bacteria, it is confirmed by microscopic observation.

The results are shown in Table 1 below.

Raw material INCI MIC (%) P E S C A CTAC Set rimonium chloride 0.25 <0.0039 <0.0039 0.0078 <0.0039 STAC Stearothiomerium chloride 0.063 0.016 0.0078 <0.00098 <0.00098 BTAC Behentrimonium chloride > 2 One <0.00098 0.00195 0.0078 SAPDA Stearamidopropyldimethylamine (ICID) N- [3- (dimethylamino) propyl] octadecanamide (JSQI) > 2 > 2 0.0078 <0.00098 0.002 ALES Ammonium polyoxyethylene lauryl ether sulfate solution 1.25 > 10 0.039 > 10 2.5 ALS Ammonium lauryl sulfate solution 0.156 > 10 0.0098 0.31 0.0098 SB Sodium benzoate 2 One 4 0.5 0.125 PE Phenoxyethanol P5 (Phenoxetol) 0.2 0.4 0.8 0.4 0.2 PK A mixture of methylchloroisothiazolinone and methylisothiazolinone 0.02 0.03 0.04 0.02 0.0016

As shown in Table 1, it can be seen that sodium benzoate, settimonium chloride and stearothermonium chloride exhibit antibacterial activity against various microorganisms.

[Reference Example] Examples and Comparative Examples Preparation

A shampoo was prepared in the following composition (unit: wt%), which was used as the base formulation of Test Example 2 below.

ingredient Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Purified water To 100 To 100 To 100 To 100 To 100 Guar hydroxypropyltrimonium chloride 0.2 0.2 0.2 0.2 0.2 Disodium edetate 0.05 0.05 0.05 0.05 0.05 Sodium salicylate 0.1 0.1 0.1 0.1 0.1 Sodium citrate 0.1 0.1 0.1 0.1 0.1 Ammonium laureth sulfate 31 31 31 31 31 Ammonium lauryl sulfate 30 30 30 30 30 Cocamidopropyl betaine 15 15 15 15 15 silicon 2 2 2 2 2 incense One One One One One antiseptic 0.23 0.23 0.23 0.23 0.23 pH adjusting agent 0.1 0.1 0.1 0.1 0.1 Viscosity modifier 0.1 0.1 0.1 0.1 0.1 CTAC 1.2 1.2 1.2 STAC 0.3 0.3 0.3 PE 0.4 0.4 0.4 SB 0.5 0.5 MI / MCI 0.05

[Test Example 2] Evaluation of buoyant force

1. Culture of strain

The same strain as that used in Test Example 1 was cultured as a test strain under the conditions shown in Table 3 below.

Culture conditions of the test strain Culture medium Incubation temperature Incubation time bacteria Tryptic soy broth (Difco) 32 ± 2.5 ° C 18 to 24 hours leaven Sabouraud dextrose broth (Difco) 22.5 ± 2.5 ° C 44 to 52 hours mold Sabouraud dextrose agar (Difco) 22.5 ± 2.5 ° C 6 to 10 days

2. Inoculation

1) Prescription samples of Table 2 were placed in a clean laboratory container with 20g or 17g + 3g of sterile ionized water (70% diluted sample).

2) Bacteria, yeast and fungi were inoculated in the following manner.

① Bacteria: Inoculate the inoculum with 0.2 ml of ⁵ × 10 ⁶ CFU / g of test sample per gram of test sample and mix homogeneously with sterilized spatula

② Yeast: The inoculum was inoculated with 0.2 ml of 10 ⁶ CFU / g of test sample per gram of test sample and mixed homogenously with sterilized spatula.

③ Mold: The inoculum was inoculated with 0.2 ml of 10 ⁶ CFU / g of test solution per gram of test sample and mixed homogenously with sterilized spatula.

3. Culture of inoculated samples

3.1. bacteria

The bacterial samples were incubated at 32 ℃ for 4 weeks. After 7, 14, and 28 days from the inoculation day, viable cell counts were measured according to the general viable cell count.

3.2. Yeast, mold

The cells were incubated for 60 days at 25 ± 2 ℃ in a constant temperature incubator and viable counts were measured after 14 and 28 days from inoculation. In addition, we observed the change in the interval of 7 days and observed the generation of mycelium on the surface of the sample with the naked eye.

4. Measurement of viable cell count

4.1. The viable cell count was measured by the following method.

(1) Sampling: Sterilized samples were thoroughly diluted using sterilized sputula, followed by dilution with sterile diluted water. If the sample weight is detected and an automatic diluter capable of automatically diluting to the desired ratio is used, it may be diluted by taking 1 ± 0.1 g. The dilution water used was the same as the dilution water used for the microbial contamination test. In order to measure the number of bacteria in the inoculum, the culture was vortexed and mixed thoroughly, then diluted with sterile diluted water.

② The viable cell count was measured using a pour plate count method. At this time, the used medium and the culture conditions are shown in Table 4 below.

Measurement of viable cell count Culture medium and culture conditions Strain Culture medium Incubation temperature Incubation time bacteria Letheen agar 32 ± 2.5 ° C 48 to 72 hours leaven Sabouraud dextrose agar 22.5 ± 2.5 ° C 5 to 7 days mold 22.5 ± 2.5 ° C 5 to 7 days

③ After cultivation, colonies were counted and viable counts were calculated.

5. Result judgment

The buoyant force of the product was evaluated in accordance with the criteria shown in Table 5, and the results are shown in Table 6 below.

Water-Based Formulation Strength Determination Criteria Rating bacteria pass No decrease in number of bacteria after 7 days, no increase after 28 days fail After 7 days, the number of bacteria decreased to 2 log or less Rating leaven pass Decreased 2 Logs after 14 days, No increase after 28 days fail After 14 days, less than 2 logs, Rating mold fail Molding on the wall / surface within 4 weeks

Results (as of the judgment date) shampoo B Y M Example 1 pass pass fail Comparative Example 1 pass pass pass Comparative Example 2 pass pass pass Comparative Example 3 pass pass fail Comparative Example 4 pass pass pass

Claims (10)

Sodium benzoate; Settimonium chloride set Rimonium chloride and stearatrimonium chloride as active ingredients. The preservative composition according to claim 1, wherein the sodium benzoate is contained in an amount of 0.01 to 2.0% by weight based on the total weight of the composition. The preservative composition according to claim 1, wherein the settimonium chloride is contained in an amount of 0.01 to 3.0% by weight based on the total weight of the composition. The preservative composition according to claim 1, wherein the stearothermolinium chloride is contained in an amount of 0.001 to 1.5% by weight based on the total weight of the composition. The preservative composition according to any one of claims 1 to 4, characterized in that the composition does not comprise phenoxyethanol or isothiazolinone-based compounds. A composition for hair and / or scalp comprising the preservative composition of any one of claims 1 to 5. 7. The composition of claim 6, wherein the composition is formulated with a hair cleanser. A shampoo comprising the composition of claim 6. A rinse comprising the composition of claim 6. A hair treatment comprising the composition of claim 6.