KR20160104010A - Wnt 경로 조절제로서의 말레이미드 유도체 - Google Patents
Wnt 경로 조절제로서의 말레이미드 유도체 Download PDFInfo
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- KR20160104010A KR20160104010A KR1020167019111A KR20167019111A KR20160104010A KR 20160104010 A KR20160104010 A KR 20160104010A KR 1020167019111 A KR1020167019111 A KR 1020167019111A KR 20167019111 A KR20167019111 A KR 20167019111A KR 20160104010 A KR20160104010 A KR 20160104010A
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- pyridin
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Classifications
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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| PCT/SG2014/000601 WO2015094118A1 (en) | 2013-12-17 | 2014-12-17 | Maleimide derivatives as modulators of wnt pathway |
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| GB201409783D0 (en) * | 2014-06-02 | 2014-07-16 | Agency Science Tech & Res | Phthalimide derivatives as modulators of WNT pathway |
| GB201604970D0 (en) * | 2016-03-23 | 2016-05-04 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| CN109867661B (zh) * | 2017-12-05 | 2022-07-19 | 中国医学科学院药物研究所 | 调节wnt信号通路的酰胺类化合物及其用途 |
| CA3086668A1 (en) * | 2018-02-05 | 2019-08-08 | Universite De Strasbourg | Compounds and compositions for the treatment of pain |
| PT3762368T (pt) | 2018-03-08 | 2022-05-06 | Incyte Corp | Compostos de aminopirazina diol como inibidores de pi3k-y |
| WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
| CN110317204B (zh) * | 2019-08-02 | 2022-02-08 | 安徽农业大学 | 吡唑并嘧啶酮类衍生物及其制备方法和应用 |
| TW202334157A (zh) * | 2022-01-29 | 2023-09-01 | 大陸商杭州阿諾生物醫藥科技有限公司 | 一種Ｗｎｔ通路抑制劑化合物 |
| CN120737090B (zh) * | 2025-08-15 | 2025-11-21 | 广州医科大学附属市八医院 | 一种化合物或组合物及其在制备具有抗癌作用的药物中的应用 |
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| US4798619A (en) | 1980-06-02 | 1989-01-17 | American Cyanamid Co. | 2-(2-imidazolin-2-yl)-pyridines and quinolines and use of said compounds as herbicidal agents |
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| KR20010079546A (ko) | 1998-07-28 | 2001-08-22 | 무라타 도시카즈 | 융합 헤테로환 디카르복실산 디아미드 유도체 또는 그의염, 제초제 및 그의 용도 |
| CA2508412C (en) | 2002-12-03 | 2011-07-26 | Bayer Cropscience S.A. | Pesticidal 5-(acylamino) pyrazole derivatives |
| CN101146811B (zh) | 2005-03-31 | 2012-01-11 | P.安杰莱蒂分子生物学研究所 | Hiv整合酶抑制剂 |
| AR067027A1 (es) | 2007-06-19 | 2009-09-30 | Astrazeneca Ab | Derivados de 2, 3-dihidro-1h-pirrol[3, 4b]quinolin-1-ona, una composicion farmaceutica que los comprende y su uso en la fabricacion de un medicamento para el tratamiento de enfermedades mediadas por la modulacion de la actividad del receptor gaba a. |
| CA2709784A1 (en) | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| FR2927331B1 (fr) * | 2008-02-07 | 2011-05-20 | Centre Nat Rech Scient | Nouveaux derives anti-infectieux, leur procede de preparation, compositions pharmaceutiques les contenant et leurs utilisations en therapeutique. |
| US8623648B2 (en) | 2008-04-24 | 2014-01-07 | Janssen Biotech, Inc. | Treatment of pluripotent cells |
| WO2010075282A1 (en) | 2008-12-22 | 2010-07-01 | University Of Washington | Molecular inhibitors of the wnt/beta-catenin pathway |
| WO2010122774A1 (ja) | 2009-04-20 | 2010-10-28 | 株式会社カネカ | (１ｓ,６ｓ)または(１ｒ,６ｒ)-シス-２,８-ジアザビシクロ[４.３.０]ノナンおよびその中間体の製造法 |
| TW201118081A (en) * | 2009-10-07 | 2011-06-01 | Siena Biotech Spa | Wnt pathway antagonists |
| WO2011056630A2 (en) | 2009-10-27 | 2011-05-12 | Trustees Of Boston University | Small molecule inhibitors of hepatitis c virus |
| US20140005164A1 (en) * | 2011-04-04 | 2014-01-02 | Siena Biotech S.P.A. | Wnt pathway antagonists |
| US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
| PH12017500997A1 (en) * | 2012-04-04 | 2018-02-19 | Samumed Llc | Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof |
| GB201309333D0 (en) * | 2013-05-23 | 2013-07-10 | Agency Science Tech & Res | Purine diones as WNT pathway modulators |
| GB201322334D0 (en) | 2013-12-17 | 2014-01-29 | Agency Science Tech & Res | Maleimide derivatives as modulators of WNT pathway |
| GB201409783D0 (en) * | 2014-06-02 | 2014-07-16 | Agency Science Tech & Res | Phthalimide derivatives as modulators of WNT pathway |
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| JP2016540802A (ja) | 2016-12-28 |
| CA2933682A1 (en) | 2015-06-25 |
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| AU2014367283B2 (en) | 2018-05-24 |
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| AU2014367283A1 (en) | 2016-06-23 |
| EP3083622A1 (en) | 2016-10-26 |
| WO2015094118A1 (en) | 2015-06-25 |
| BR112016013618A8 (pt) | 2020-05-19 |
| JP6511450B2 (ja) | 2019-05-15 |
| EP3083622B1 (en) | 2018-03-21 |
| CN106061974A (zh) | 2016-10-26 |
| US20160318926A1 (en) | 2016-11-03 |
| ES2674096T3 (es) | 2018-06-27 |
| GB201322334D0 (en) | 2014-01-29 |
| US9981964B2 (en) | 2018-05-29 |
| SG11201604848UA (en) | 2016-07-28 |
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