KR20160094524A - Preservative composition containing benzyl glycol as an active ingredient - Google Patents

Abstract

The present invention relates to a preservative composition containing benzyl glycol represented by chemical formula 1 as an active component. According to the present invention, the composition comprises 0.5-2.0 wt% of benzyl glycol as an active component with respect to the total weight of the composition, thereby having excellent antibacterial, antifungal, and antiseptic abilities without the use of conventional chemical preservatives; and being used widely as a preservative for externals, food, and household goods as the composition rarely causes side effects to the skin and is harmless to the human body even if the composition is taken orally.

Description

A preservative composition containing benzylglycol as an active ingredient {containing benzyl glycol as an active ingredient}

The present invention relates to a preservative composition, and more particularly, to a preservative composition containing a specific glycol derivative, which is excellent in antibacterial activity, antifungal activity and antifungal property, and has no harmful effects on human body such as skin irritation. Pharmaceuticals and the like, which can be widely used.

Various products such as cosmetics and human products are suitable for growth of microorganisms because they contain various materials such as moisturizers, oils, surfactants, inorganic powders, organic water-soluble polymers and perfumes.

Therefore, it is common to add a chemical preservative to prevent the product from being corrupted by the microorganism and to kill the microorganism over time to prevent deterioration of the product. As such chemical preservatives, parabens, imidazolidinyl urea, phenoxyethanol, paraoxybenzoic acid esters, benzalkonium chloride and the like are generally used.

However, recently, new additives such as proteins, gums, vitamins, and medicinal plants have been added to products, resulting in a variety of changes due to the action of microorganisms, and the preservative effect by chemical preservatives is weakened and the content of chemical preservatives is increasing. As the content of the chemical preservative increases, problems of human harm such as irritation to the skin and allergic symptoms are caused.

Korean Patent Publication No. 10-2014-0015109 Japanese Patent Application No. 2012-164617

Accordingly, a technical problem to be solved by the present invention is to provide an antimicrobial agent, an antifungal agent, and an antifungal agent which are excellent in usability and are excellent in antimicrobial activity, antifungal activity and antifungal property even when a chemical preservative such as parabens, Such as skin irritation, irritation, allergic symptoms, and the like, even if added to foods and the like.

In order to solve the problems of the prior art, the present inventors have tested various components and benzylglycols of the following formula (1) were able to achieve antibacterial, antifungal and preservative effects, and as a result, chemical preservatives And that it is harmless to the human body, such as not causing skin side effects, as well as being able to reduce the amount thereof. Thereby completing the invention.

Therefore, in order to solve the above problems,

The present invention provides a preservative composition, which comprises 0.5 to 2.0% by weight of benzyl glycol as the active ingredient based on the total weight of the composition.

The preservative composition according to the present invention may further contain paraben as an active ingredient in an amount of 0.05 to 0.1% by weight based on the total weight of the composition, and the benzyl glycol may be contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition .

As described above, the preservative composition according to the present invention may contain at least one selected from the group consisting of phenoxyethanol, ethylhexyl glycerin, butoxy diglycol, methoxydiglycol, 1,2,6-hexanetriol, raspberry ketone and 1,2- , 0.1 to 0.5% by weight based on the total weight of the composition, and the benzyl glycol may be contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition.

The preservative composition according to the present invention may further comprise 0.01 to 0.1% by weight, based on the total weight of the composition, of troopolone or caprylhydroxamic acid as an active ingredient, 1.0% by weight.

The preservative composition according to the present invention may further contain 0.2 to 0.5% by weight, based on the total weight of the composition, of glyceryl caprylate as an active ingredient, and the benzyl glycol is contained in an amount of 0.5 to 1.0% by weight can do.

The preservative composition according to the present invention as described above further comprises capryllylicol as an active ingredient in an amount of 0.05 to 0.2% by weight based on the total weight of the composition, and the benzylglycol is used in an amount of 0.5 to 1.0% ≪ / RTI >

The preservative composition according to the present invention as described above can be added as a preservative to any one external preparation selected from the group consisting of a cosmetic composition, a composition for external use on the skin, a quasi drug composition, and an external pharmaceutical composition.

Since the preservative composition of the present invention contains benzyl glycol as an active ingredient and can exhibit excellent antibacterial, antifungal and antiseptic effects, it can be used without using a chemical preservative or using a small amount of a chemical preservative It is possible to exhibit excellent antibacterial and antiseptic effects even when used. Therefore, unlike conventional cosmetic products, quasi-drugs, and skin external drug compositions, which use an excessive amount of a chemical preservative, cause side effects such as skin irritation and allergies, the preservative composition of the present invention scarcely causes such skin side effects . In addition, the preservative composition of the present invention has no toxicity to human body even when it is taken, and is a preservative composition having a very wide range of use that can be used for foods, oral administration medicines and the like.

Furthermore, the preservative composition according to the present invention is not classified as a conventional chemical preservative or a chemical preservative, but synergistic effect is generated when it is used together with components having a buoyancy, so that more excellent antibacterial and preservative effects can be exhibited.

Specific details for carrying out the present invention will be described.

The present invention has excellent antimicrobial activity, antifungal activity and antifungal activity even when a chemical preservative such as parabens, which have been widely used, is not used or a small amount thereof is used, but also excellent usability, The present inventors have tested various components to solve the problems of the prior art. The present inventors have conducted extensive researches on various kinds of ingredients, Among the components, benzylglycol having the following formula (1) was able to achieve antibacterial, antifungal and antiseptic effects. As a result, not only the chemical preservative can be used or its content can be reduced, Found that Thereby completing the invention.

Accordingly, the present invention provides a preservative composition containing benzylglycol of Formula 1, which has a wide range of use, without any adverse effects on the skin and human toxicity upon administration, in an amount of 0.5 to 2.0% by weight based on the total weight of the composition.

The composition according to the present invention as described above plays an important role as an excellent preservative even when benzyl glycol alone is not used as a preservative and that its content is 0.5 to 2.0 wt% It was completed by proving that.

In addition, although the composition of the present invention is not classified as a conventional chemical preservative or chemical preservative, synergistic effect is generated when it is used together with components having a buoyant force, so that more excellent antibacterial and preservative effects can be exhibited. The preservative composition according to the invention comprises from 0.05 to 0.1% by weight, based on the total weight of the composition, of parabens as active ingredients, wherein the benzyl glycols are present in an amount of from 0.5 to 1.0% by weight, Because of the excellent effect of benzyl glycols, the amount of other preservatives used can also be very small in the present invention.

Also, the preservative composition according to the present invention as described above may be at least one selected from the group consisting of phenoxyethanol, ethylhexylglycerin, butoxydiglycol, methoxydiglycol, 1,2,6-hexanetriol, raspberry ketone and 1,2- And diol as an active ingredient in an amount of 0.1 to 0.5% by weight based on the total weight of the composition, wherein the benzyl glycol is used in an amount of 0.5 to 1.0% by weight based on the total weight of the composition, Because of the excellent effect of benzyl glycols, the amount of other preservatives used can also be very small in the present invention.

In addition, the preservative composition according to the present invention may further comprise 0.01 to 0.1% by weight of tropolone or caprylhydroxamic acid based on the total weight of the composition as an active ingredient, By weight, 0.5 to 1.0% by weight is much smaller than when it is used alone, and the amount of other preservatives can be used in a very small amount in the present invention because of the excellent effect of benzyl glycol.

Also, the preservative composition according to the present invention may further comprise 0.2 to 0.5% by weight, based on the total weight of the composition, of glyceryl caprylate as an active ingredient, wherein the benzyl glycol is used in an amount of 0.5 to 1.0 By weight, much smaller amounts are contained than when used alone, and because of the excellent effect of benzyl glycol, the amount of other preservatives can also be used in a very small amount in the present invention.

In addition, the preservative composition according to the present invention as described above further comprises capryllylicol as an active ingredient in an amount of 0.05 to 0.2% by weight based on the total weight of the composition, 1.0 wt.%, Which is much smaller than when it is used alone, and the amount of other preservatives used can also be very small in the present invention because of the excellent effect of benzyl glycol.

In the present invention, benzylglycol is used as an active ingredient exhibiting antibacterial, antifungal and antiseptic effects. In addition to its role as a preservative, this benzylglycol has many other useful applications, .

Specifically, the active ingredient of the composition according to the present invention, benzylglycol, is a colorless transparent liquid, which is easily dissolved in water and does not require the use of a solubilizing agent, thereby reducing production costs.

Furthermore, the composition containing benzyl glycol according to the present invention can be used to produce a cosmetic composition by a known cosmetic preparation method, and is applicable not only to general skin cosmetic compositions but also to daily necessities, quasi drugs, external medicine, foods can do.

These formulations may be prepared in any conventional formulation and may be in the form of, for example, an emulsion, a microemulsion, a skin, a lotion, a cream, a foundation, an essence, a gel, a pack, a foam cleanser, a softening longevity, But the present invention is not limited thereto, and may be manufactured in the form of an eyeliner, a shampoo, a rinse, a soap, a body cleanser, a regular detergent, a hair dye, a toothpaste, a female cleanser, a wet tissue, a mouth cleanser,

In addition, in the cosmetic composition of each formulation, other components other than the above-mentioned benzyl glycol may be selected and mixed without difficulty by those skilled in the art depending on the formulations of the other cosmetics, the purpose of use, and the like.

For better understanding of the present invention, embodiments and the like will be described in detail. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the present invention are provided to more fully describe the present invention to those skilled in the art.

≪ Preparation of test composition 1 >

A liquid type composition was prepared by a conventional method using the composition components and contents shown in Table 1 below. The compositions according to the present invention were referred to as Examples 1 to 3, and the compositions to be compared with the compositions according to the present invention were named as Comparative Examples 1 to 2 Respectively.

Category (% by weight) Example Comparative Example One 2 3 One  2 Purified water to 100 to 100 to 100 to 100 to 100 Benzyl glycol 0.5 One 2 - - glycerin 3 3 3 3 3 Wax 3 3 3 3 3 butter 2 2 2 2 2 High fatty acid 3 3 3 3 3 Polystearate 3 3 3 3 3 Xanthan gum 0.03 0.03 0.03 0.03 0.03 incense q.s. q.s. q.s. q.s. q.s. Methyl paraben - - - 0.2 - Ethyl paraben - - - 0.1 - Propylparaben - - - 0.1 -

≪ Test Example 1: Effectiveness test as a preservative &

In order to test the antimicrobial and antiseptic effects of Examples 1-3 and 1-2, bacteria or fungi were added to the samples and the change in the number of inoculated bacteria was confirmed. When the number of fungi or bacteria started to become less than 20 CFU / g The blades were recorded as shown in Table 2 below and measured up to 28 days. The test procedure is as follows.

First, 40 g of each sample was loaded, and then the bacterium, namely Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa ATCC 15522, Escherichia coli ATCC 10536, and the like Was added to the sample so that the number of samples was 10 ⁶ per 1 g of the sample, and the mixture was stored for 4 weeks. Then, the change in the number of inoculated bacteria was observed every 1 day, 7 days, 14 days, 21 days, and 28 days after the inoculation day.

The test procedure using fungi is the same as the test using bacteria, except that fungi Aspergillus niger ATCC 9642 and Candida albicans ATCC 10231 were used instead of bacteria.

Evaluation items Example Comparative Example One 2 3 One 2 Germ 7 days 7 days 1 day 14 days More than 28 days Fungus 14 days 7 days 1 day 14 days More than 28 days

As shown in Table 2, Comparative Example 2 showed no antibacterial, antifungal and preservative effect because no preservative or chemical preservative was used. In Comparative Example 1, 0.4% by weight of total parabens were used, And the number of fungi or bacteria of 20 CFU / g or less was low, and the antibacterial and preservative effect was low.

On the other hand, Example 1 of the present invention did not use the conventional chemical preservative, and even though only 0.5% by weight of benzyl glycols were used, bacteria and fungi of 7 days and 14 days later, bacteria of 20 CFU / And the fungus number was higher than that of Comparative Example 1 using the chemical preservative.

In particular, in the case of Examples 2 and 3 containing 1 and 2% by weight of benzylglycol, the number of fungi and bacteria was drastically reduced and the number of fungi or bacteria of less than 20 CFU / g from the 7th day and the 1st day, respectively Indicating that it exhibited much better antibacterial, antifungal and antiseptic effects than Comparative Example 1 containing a chemical preservative.

≪ Test Example 2: skin irritation evaluation test >

To evaluate the skin irritation of the compositions of Example 3 and Comparative Example 1, the first stimulation test was performed on human body through the human patch test as follows.

The CTFA guidelines for healthy adults and boys [Reference: The Cosmetic, Toility and Fragrance Association. Inc. Washington, DC, June 1994, 1994). 15 mL of the sample and solution was dropped into a Finn chamber, and this was placed on the back of the human body to be tested and fixed with a tape. After 24 hours, the patches were removed. After 4 hours, the skin reaction of the test site was judged according to the following criteria. The results are shown in Table 3 below.

<Criteria>

-: No erythema or special symptoms

+/-: Slightly redder than surrounding

+: Significantly reddened than surrounding

++: More reddening and swelling than the surrounding area

The number of test subjects = number of test subjects = number of test subjects (number of test subjects)

sample Tested embroidery Judgment result Irritation degree ++ + +/- - Example 3 30 0 0 One 29 0.03 Comparative Example 1 30 0 One 4 25 0.2

As shown in Table 3, in the case of Example 2 using benzylglycol as a preservative, skin irritation was significantly reduced as compared with Comparative Example 1 using a chemical preservative.

&Lt; Preparation 2 of test composition >

In order to test the antimicrobial and preservative effects of benzyl glycols contained in the composition of the present invention and the synergistic effects of the antifungal and antiseptic ingredients, which were not classified as chemical preservatives or chemical preservatives, the following Tables 4, 5 and 6 And the compositional ingredients and the contents shown in Table 7 were prepared in an emulsion type in a conventional manner.

Examples 4 to 15 are benzyl glycols which are not classified as conventional chemical preservatives or preservatives but which have a preservative effect added thereto. In order to demonstrate the superior effect of benzyl glycol, %, And the components contained in benzyl glycols were also contained in the lowest amount in the use range. Comparative Examples 4 to 15 contain only the components known to exhibit conventional chemical preservatives or preservative effects without benzyl glycol.

Category (% by weight) Example 4 5 6 7 8 9 10 11 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Benzyl glycol 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Phenoxyethanol 0.1 - - - - - - - Ethylhexyl glycerin - 0.1 - - - - - - Butoxydiglycol - - 0.1 - - Methoxydiglycol - - - 0.1 - - - - 1,2,6-hexanetriol - - - - 0.1 - Caprylic hydroxamic acid - - - - - 0.01 - - Troponone - - - - - - 0.01 - Glyceryl caprylate - - - - - - - 0.2 Raspberry ketone - - - - - - - - 1,2-hexanediol - - - - - - - - Caprile Glicol - - - - - - - - glycerin 3 3 3 3 3 3 3 3 Wax 3 3 3 3 3 3 3 3 butter 2 2 2 2 2 2 2 2 High fatty acid 3 3 3 3 3 3 3 3 Polystearate 3 3 3 3 3 3 3 3 Xanthan gum 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 incense q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Methylparaben - - - - - - - - Ethylparaben - - - - - - - - Propylparaben - - - - - - - -

Category (% by weight) Example 12 13 14 15 Purified water to 100 to 100 to 100 to 100 Benzyl glycol 0.5 0.5 0.5 0.5 Phenoxyethanol - - - - Ethylhexyl glycerin - - - - Butoxydiglycol - - - - Methoxydiglycol - - - - 1,2,6-hexanetriol - - - - Caprylic hydroxamic acid - - - - Troponone - - - - Glyceryl caprylate - - - - Raspberry ketone 0.1 - - - 1,2-hexanediol - 0.1 - - Caprile Glicol - - 0.05 - glycerin 3 3 3 3 Wax 3 3 3 3 butter 2 2 2 2 High fatty acid 3 3 3 3 Polystearate 3 3 3 3 Xanthan gum 0.03 0.03 0.03 0.03 incense q.s. q.s. q.s. q.s. Methylparaben - - - 0.05 Ethylparaben - - - 0.05 Propylparaben - - - 0.05

Category (% by weight) Comparative Example 4 5 6 7 8 9 10 11 Purified water to 100 to 100 to 100 to 100 to 100 to 100 to 100 to 100 Benzyl glycol - - - - - - - - Phenoxyethanol 1.0 - - - - - - - Ethylhexyl glycerin - 1.0 - - - - - - Butoxydiglycol - - 1.0 - - Methoxydiglycol - - - 1.0 - - - - 1,2,6-hexanetriol - - - - 1.0 - Caprylic hydroxamic acid - - - - - 1.0 - - Troponone - - - - - - 0.2 - Glyceryl caprylate - - - - - - - 0.5 Raspberry ketone - - - - - - - - 1,2-hexanediol - - - - - - - - Caprile Glicol - - - - - - - - glycerin 3 3 3 3 3 3 3 3 Wax 3 3 3 3 3 3 3 3 butter 2 2 2 2 2 2 2 2 High fatty acid 3 3 3 3 3 3 3 3 Polystearate 3 3 3 3 3 3 3 3 Xanthan gum 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 incense q.s. q.s. q.s. q.s. q.s. q.s. q.s. q.s. Methylparaben - - - - - - - - Ethylparaben - - - - - - - - Propylparaben - - - - - - - -

Category (% by weight) Comparative Example 12 13 14 15 Purified water to 100 to 100 to 100 to 100 Benzyl glycol - - - - Phenoxyethanol - - - - Ethylhexyl glycerin - - - - Butoxydiglycol - - - - Methoxydiglycol - - - - 1,2,6-hexanetriol - - - - Caprylic hydroxamic acid - - - - Troponone - - - - Glyceryl caprylate - - - - Raspberry ketone 1.0 - - - 1,2-hexanediol - 1.0 - - Caprile Glicol - - 1.0 - glycerin 3 3 3 3 Wax 3 3 3 3 butter 2 2 2 2 High fatty acid 3 3 3 3 Polystearate 3 3 3 3 Xanthan gum 0.03 0.03 0.03 0.03 incense q.s. q.s. q.s. q.s. Methylparaben - - - 0.5 Ethylparaben - - - 0.5 Propylparaben - - - 0.5

&Lt; Test Example 3: Effectiveness test as a preservative &

In order to test the antimicrobial and preservative effects, which were not classified as benzyl glycols and chemical preservatives or chemical preservatives according to the present invention but were enhanced by the synergistic effect of the components having buoyancy, Examples 4-15 and 4-15 Were added to the samples to confirm the change in the number of inoculated bacteria. The days on which the number of fungi or bacteria started to become 20 CFU / g or less were recorded and shown in the following Tables 8 and 9, and measured up to 28 days. The test procedure is the same as in Test Example 1 above.

Evaluation items Example 3 4 5 6 7 8 9 10 11 12 13 14 15 Germ 7 One 4 One One One 7 5 One 3 4 2 One Fungus 7 2 4 One One One 7 5 2 4 4 2 One

Evaluation items Comparative Example 4 5 6 7 8 9 10 11 12 13 14 15 Germ 10 10 10 10 10 10 12 11 10 10 10 28 Fungus 15 15 20 21 22 23 22 18 10 10 28 14

As shown in Tables 9 and 10, in the case of Comparative Example 4-15, which is not classified as a chemical preservative or a chemical preservative but contains a flotation component, the number of fungi or bacteria of 20 CFU / g or less after 10 days But in the case of Example 4-15 containing benzyl glycols of the present invention, the number of fungi or bacteria of 20 CFU / g or less was exhibited from 1 day to 7 days, showing excellent antibacterial and antiseptic effects as compared with Comparative Example .

In particular, benzyl glycols used as preservatives in Examples 4 to 15 and synergistic effects due to the combined use of antimicrobial and chemical preservatives, but not benzyl glycols, The antibacterial and antiseptic effect was significantly improved as compared with Example 3, which was only used.

&Lt; Test Example 4: skin irritation evaluation test >

In order to evaluate the skin irritation of Examples 4-15 and 3-14, the first stimulation test was performed on the human body in the same manner as in Test Example 2, and the results are shown in Table 10 below.

sample Tested embroidery Judgment result Irritation degree ++ + +/- - Example 4 30 0 0 2 27 0.06 Example 5 30 0 0 One 29 0.03 Example 6 30 0 0 One 27 0.06 Example 7 30 0 0 One 27 0.06 Example 8 30 0 0 One 27 0.06 Example 9 30 0 0 One 27 0.06 Example 10 30 0 0 One 27 0.06 Example 11 30 0 0 2 27 0.06 Example 12 30 0 0 One 27 0.06 Example 13 30 0 0 2 27 0.06 Example 14 30 0 0 One 27 0.06 Example 15 30 0 0 2 27 0.06 Comparative Example 4 30 One One 4 24 0.3 Comparative Example 5 30 0 One 3 26 0.16 Comparative Example 6 30 One One 4 24 0.3 Comparative Example 7 30 One One 4 24 0.3 Comparative Example 8 30 One One 4 24 0.3 Comparative Example 9 30 One One 4 26 0.16 Comparative Example 10 30 0 One 4 26 0.16 Comparative Example 11 30 One One 4 24 0.3 Comparative Example 12 30 0 One 4 24 0.3 Comparative Example 13 30 One One 4 24 0.3 Comparative Example 14 30 One One 4 24 0.3 Comparative Example 15 30 One One 4 24 0.3

As shown in Table 10, it can be seen that Examples 4-15 contained only trace amounts of chemical preservatives and skin irritation was significantly less than Comparative Examples 4-15 using relatively high amounts of chemical preservatives.

Claims (7)

A preservative composition according to claim 1, wherein the composition contains 0.5 to 2.0% by weight of benzyl glycol as an active ingredient based on the total weight of the composition.
[Chemical Formula 1]

The preservative composition according to claim 1, further comprising 0.05 to 0.1% by weight of parabens as an active ingredient based on the total weight of the composition, wherein the benzyl glycols are contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition.
The method according to claim 1, wherein the polymer is selected from the group consisting of phenoxyethanol, ethylhexyl glycerin, butoxy diglycol, methoxydiglycol, 1,2,6-hexanetriol, raspberry ketone and 1,2-hexanediol By weight based on the total weight of the composition, and the benzyl glycols are contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition.
The composition according to claim 1, further comprising 0.01 to 0.1% by weight, based on the total weight of the composition, of troopolone or caprylhydroxamic acid as an active ingredient, wherein the benzyl glycols are contained in an amount of 0.5 to 1.0% &Lt; / RTI &gt;
The composition according to claim 1, further comprising 0.2 to 0.5% by weight of glyceryl caprylate as an active ingredient based on the total weight of the composition, wherein the benzyl glycols are contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition / RTI &gt;
The cosmetic composition according to claim 1, further comprising capryllylicol as an active ingredient in an amount of 0.05 to 0.2% by weight based on the total weight of the composition, wherein the benzyl glycols are contained in an amount of 0.5 to 1.0% by weight based on the total weight of the composition &Lt; / RTI &gt;
The preservative composition according to any one of claims 1 to 6, which is added as a preservative to any one external preparation selected from the group consisting of a cosmetic composition, an external skin cosmetic composition, a quasi drug composition and an external medicine composition .