KR20160086837A - 프로스타사이클린 유사체의 아민 염 - Google Patents

프로스타사이클린 유사체의 아민 염 Download PDF

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Publication number
KR20160086837A
KR20160086837A KR1020167012739A KR20167012739A KR20160086837A KR 20160086837 A KR20160086837 A KR 20160086837A KR 1020167012739 A KR1020167012739 A KR 1020167012739A KR 20167012739 A KR20167012739 A KR 20167012739A KR 20160086837 A KR20160086837 A KR 20160086837A
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South Korea
Prior art keywords
compound
formula
produce
organic solvent
reacting
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KR1020167012739A
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English (en)
Korean (ko)
Inventor
질스 챔보우른니어
그레고리 윌리엄 엔드레스
키르크 윌리엄 헤링
빅터 페디즈
후세인 마흐무드 마흐무드
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카이맨 케미칼 컴파니 인코포레이티드
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Publication of KR20160086837A publication Critical patent/KR20160086837A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/62—Quaternary ammonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07C2103/14—
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
KR1020167012739A 2013-11-13 2014-11-07 프로스타사이클린 유사체의 아민 염 Withdrawn KR20160086837A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361903730P 2013-11-13 2013-11-13
US61/903,730 2013-11-13
PCT/US2014/064519 WO2015073314A1 (en) 2013-11-13 2014-11-07 Amine salts of a prostacyclin analog

Publications (1)

Publication Number Publication Date
KR20160086837A true KR20160086837A (ko) 2016-07-20

Family

ID=51982791

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167012739A Withdrawn KR20160086837A (ko) 2013-11-13 2014-11-07 프로스타사이클린 유사체의 아민 염

Country Status (9)

Country Link
US (2) US9890104B2 (cg-RX-API-DMAC10.html)
EP (1) EP3068752A1 (cg-RX-API-DMAC10.html)
JP (1) JP6373378B2 (cg-RX-API-DMAC10.html)
KR (1) KR20160086837A (cg-RX-API-DMAC10.html)
CN (1) CN105722812B (cg-RX-API-DMAC10.html)
AU (1) AU2014349000B2 (cg-RX-API-DMAC10.html)
CA (1) CA2930574A1 (cg-RX-API-DMAC10.html)
IL (1) IL245357B (cg-RX-API-DMAC10.html)
WO (1) WO2015073314A1 (cg-RX-API-DMAC10.html)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104837806A (zh) * 2012-12-07 2015-08-12 开曼化学股份有限公司 前列环素类似物的合成方法
EP3712142B1 (en) 2013-01-11 2022-07-06 Corsair Pharma, Inc. Prodrugs of treprostinil
US9505737B2 (en) 2013-01-11 2016-11-29 Corsair Pharma, Inc. Treprostinil derivative compounds and methods of using same
US9643911B2 (en) 2015-06-17 2017-05-09 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
US9394227B1 (en) 2015-06-17 2016-07-19 Corsair Pharma, Inc. Treprostinil derivatives and compositions and uses thereof
KR101830693B1 (ko) * 2016-04-28 2018-02-21 연성정밀화학(주) 트레프로스티닐의 제조방법 및 이를 위한 중간체
CN107602376A (zh) * 2017-10-30 2018-01-19 上海泰坦科技股份有限公司 一种曲列前尼尔的合成方法
CN112739679B (zh) * 2018-09-18 2024-03-12 伊莱利利公司 曲前列环素的特丁胺盐

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4306075A (en) 1980-03-28 1981-12-15 The Upjohn Company Composition and process
JPH09100294A (ja) * 1995-10-02 1997-04-15 Tsumura & Co 血管新生阻害剤
US6441245B1 (en) 1997-10-24 2002-08-27 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
US6700025B2 (en) 2001-01-05 2004-03-02 United Therapeutics Corporation Process for stereoselective synthesis of prostacyclin derivatives
WO2009078965A1 (en) * 2007-12-17 2009-06-25 United Therapeutics Corporation An improved process to prepare treprostinil, the active ingredient in remodulin
CN103261142B (zh) 2010-06-03 2014-12-10 联合治疗公司 曲前列环素的制备
CA2710726C (en) 2010-07-22 2016-02-23 Alphora Research Inc. Synthesis of treprostinil and intermediates useful therein
WO2012041334A1 (en) * 2010-10-01 2012-04-05 Rigshospitalet Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest
CN104837806A (zh) * 2012-12-07 2015-08-12 开曼化学股份有限公司 前列环素类似物的合成方法

Also Published As

Publication number Publication date
JP6373378B2 (ja) 2018-08-15
US20160289158A1 (en) 2016-10-06
CA2930574A1 (en) 2015-05-21
AU2014349000A1 (en) 2016-06-09
EP3068752A1 (en) 2016-09-21
CN105722812A (zh) 2016-06-29
US9890104B2 (en) 2018-02-13
AU2014349000B2 (en) 2019-01-17
IL245357B (en) 2019-10-31
JP2016537363A (ja) 2016-12-01
WO2015073314A1 (en) 2015-05-21
US20180118656A1 (en) 2018-05-03
US10155716B2 (en) 2018-12-18
CN105722812B (zh) 2018-11-16
IL245357A0 (en) 2016-06-30

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Patent event date: 20160513

Patent event code: PA01051R01D

Comment text: International Patent Application

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Patent event code: PA02012R01D

Patent event date: 20191107

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Comment text: [Withdrawal of Procedure relating to Patent, etc.] Withdrawal (Abandonment)

Patent event code: PC12021R01D

Patent event date: 20191226

WITB Written withdrawal of application