IL245357B - Amine salts of a prostacyclin analog - Google Patents
Amine salts of a prostacyclin analogInfo
- Publication number
- IL245357B IL245357B IL24535716A IL24535716A IL245357B IL 245357 B IL245357 B IL 245357B IL 24535716 A IL24535716 A IL 24535716A IL 24535716 A IL24535716 A IL 24535716A IL 245357 B IL245357 B IL 245357B
- Authority
- IL
- Israel
- Prior art keywords
- amine salts
- prostacyclin analog
- prostacyclin
- analog
- amine
- Prior art date
Links
- -1 Amine salts Chemical class 0.000 title 1
- 150000003815 prostacyclins Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/62—Quaternary ammonium compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361903730P | 2013-11-13 | 2013-11-13 | |
| PCT/US2014/064519 WO2015073314A1 (en) | 2013-11-13 | 2014-11-07 | Amine salts of a prostacyclin analog |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL245357A0 IL245357A0 (en) | 2016-06-30 |
| IL245357B true IL245357B (en) | 2019-10-31 |
Family
ID=51982791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL24535716A IL245357B (en) | 2013-11-13 | 2016-05-01 | Amine salts of a prostacyclin analog |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9890104B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP3068752A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP6373378B2 (cg-RX-API-DMAC10.html) |
| KR (1) | KR20160086837A (cg-RX-API-DMAC10.html) |
| CN (1) | CN105722812B (cg-RX-API-DMAC10.html) |
| AU (1) | AU2014349000B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2930574A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL245357B (cg-RX-API-DMAC10.html) |
| WO (1) | WO2015073314A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
| EP3712142B1 (en) | 2013-01-11 | 2022-07-06 | Corsair Pharma, Inc. | Prodrugs of treprostinil |
| US9505737B2 (en) | 2013-01-11 | 2016-11-29 | Corsair Pharma, Inc. | Treprostinil derivative compounds and methods of using same |
| US9643911B2 (en) | 2015-06-17 | 2017-05-09 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| US9394227B1 (en) | 2015-06-17 | 2016-07-19 | Corsair Pharma, Inc. | Treprostinil derivatives and compositions and uses thereof |
| KR101830693B1 (ko) * | 2016-04-28 | 2018-02-21 | 연성정밀화학(주) | 트레프로스티닐의 제조방법 및 이를 위한 중간체 |
| CN107602376A (zh) * | 2017-10-30 | 2018-01-19 | 上海泰坦科技股份有限公司 | 一种曲列前尼尔的合成方法 |
| CN112739679B (zh) * | 2018-09-18 | 2024-03-12 | 伊莱利利公司 | 曲前列环素的特丁胺盐 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4306075A (en) | 1980-03-28 | 1981-12-15 | The Upjohn Company | Composition and process |
| JPH09100294A (ja) * | 1995-10-02 | 1997-04-15 | Tsumura & Co | 血管新生阻害剤 |
| US6441245B1 (en) | 1997-10-24 | 2002-08-27 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| US6700025B2 (en) | 2001-01-05 | 2004-03-02 | United Therapeutics Corporation | Process for stereoselective synthesis of prostacyclin derivatives |
| WO2009078965A1 (en) * | 2007-12-17 | 2009-06-25 | United Therapeutics Corporation | An improved process to prepare treprostinil, the active ingredient in remodulin |
| CN103261142B (zh) | 2010-06-03 | 2014-12-10 | 联合治疗公司 | 曲前列环素的制备 |
| CA2710726C (en) | 2010-07-22 | 2016-02-23 | Alphora Research Inc. | Synthesis of treprostinil and intermediates useful therein |
| WO2012041334A1 (en) * | 2010-10-01 | 2012-04-05 | Rigshospitalet | Compounds capable of modulating/preserving endothelial integrity for use in prevention or treatment of acute traumatic coagulopathy and resuscitated cardiac arrest |
| CN104837806A (zh) * | 2012-12-07 | 2015-08-12 | 开曼化学股份有限公司 | 前列环素类似物的合成方法 |
-
2014
- 2014-11-07 WO PCT/US2014/064519 patent/WO2015073314A1/en not_active Ceased
- 2014-11-07 EP EP14803019.0A patent/EP3068752A1/en not_active Withdrawn
- 2014-11-07 CA CA2930574A patent/CA2930574A1/en not_active Abandoned
- 2014-11-07 US US15/036,219 patent/US9890104B2/en not_active Expired - Fee Related
- 2014-11-07 KR KR1020167012739A patent/KR20160086837A/ko not_active Withdrawn
- 2014-11-07 JP JP2016530933A patent/JP6373378B2/ja not_active Expired - Fee Related
- 2014-11-07 CN CN201480062328.4A patent/CN105722812B/zh not_active Expired - Fee Related
- 2014-11-07 AU AU2014349000A patent/AU2014349000B2/en not_active Ceased
-
2016
- 2016-05-01 IL IL24535716A patent/IL245357B/en not_active IP Right Cessation
-
2017
- 2017-12-22 US US15/852,922 patent/US10155716B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP6373378B2 (ja) | 2018-08-15 |
| US20160289158A1 (en) | 2016-10-06 |
| CA2930574A1 (en) | 2015-05-21 |
| AU2014349000A1 (en) | 2016-06-09 |
| EP3068752A1 (en) | 2016-09-21 |
| CN105722812A (zh) | 2016-06-29 |
| KR20160086837A (ko) | 2016-07-20 |
| US9890104B2 (en) | 2018-02-13 |
| AU2014349000B2 (en) | 2019-01-17 |
| JP2016537363A (ja) | 2016-12-01 |
| WO2015073314A1 (en) | 2015-05-21 |
| US20180118656A1 (en) | 2018-05-03 |
| US10155716B2 (en) | 2018-12-18 |
| CN105722812B (zh) | 2018-11-16 |
| IL245357A0 (en) | 2016-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| MM9K | Patent not in force due to non-payment of renewal fees |