KR20160072506A - Deaeration apparatus and apparatus for applying diagnostic reagent including the same - Google Patents

Deaeration apparatus and apparatus for applying diagnostic reagent including the same Download PDF

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Publication number
KR20160072506A
KR20160072506A KR1020140180212A KR20140180212A KR20160072506A KR 20160072506 A KR20160072506 A KR 20160072506A KR 1020140180212 A KR1020140180212 A KR 1020140180212A KR 20140180212 A KR20140180212 A KR 20140180212A KR 20160072506 A KR20160072506 A KR 20160072506A
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South Korea
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space
diagnostic reagent
container
membrane
partition
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KR1020140180212A
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Korean (ko)
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신상민
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주식회사 제타
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Priority to KR1020140180212A priority Critical patent/KR20160072506A/en
Publication of KR20160072506A publication Critical patent/KR20160072506A/en

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/02—Foam dispersion or prevention
    • C—CHEMISTRY; METALLURGY
    • C03—GLASS; MINERAL OR SLAG WOOL
    • C03B—MANUFACTURE, SHAPING, OR SUPPLEMENTARY PROCESSES
    • C03B5/00—Melting in furnaces; Furnaces so far as specially adapted for glass manufacture
    • C03B5/16—Special features of the melting process; Auxiliary means specially adapted for glass-melting furnaces
    • C03B5/225—Refining
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/812—Foam control

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Degasification And Air Bubble Elimination (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Disclosed are a deaeration device and a diagnostic reagent application apparatus including the same. The diagnostic reagent application apparatus includes: a container; a partition dividing an inner space of the container into a first space for diagnostic reagent accommodation and a second space acting as a vacuum chamber; a vacuum pump connected to the second space; a nozzle for applying a diagnostic reagent onto a membrane; a supply pipe for connection between the container and the nozzle; and a supply pump connected to the supply pipe and supplying the diagnostic reagent through the nozzle. At least a part of the partition is formed of a porous material so that bubbles in the diagnostic reagent are discharged through the second space.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention [0001] The present invention relates to a defoaming apparatus,

The present invention relates to a defoaming device and a diagnostic reagent application device including the defoaming device. More particularly, the present invention relates to a defoaming device for removing air bubbles from a liquid such as a diagnostic reagent, and a diagnostic reagent application device for applying the diagnostic reagent onto the membrane using the same.

Recently, diagnostic kits for diagnosing diseases such as hepatitis, diabetes, anemia, hyperlipemia, AIDS, etc., or pregnancy by using body fluids such as urine and blood have been widely used. The diagnostic kit may include a diagnostic strip capable of diagnosing disease or pregnancy using the body fluid.

The diagnostic strip may include a base card made of plastic and a bonding pad, an absorbent pad, a membrane pad, a sample pad, etc., which are adhered to the base card through an adhesive. The membrane pad may be coated with a diagnostic reagent for determining the disease or pregnancy, and the membrane pad coated with the diagnostic reagent may be protected by a protective agent.

The diagnostic reagent may be applied using a nozzle on the membrane while continuously conveying the membrane in the form of a strip using a supply roller and a collection roller. In addition, the membrane to which the diagnostic reagent is applied as described above may be transported through the protective agent solution contained in the container, whereby the protective agent solution may be coated on the membrane. However, the diagnostic reagent may be non-uniformly applied on the membrane by the bubbles in the diagnostic reagent, so that errors in the judgment of the disease using the diagnostic reagent or the pregnancy may occur.

Korean Patent Publication No. 10-2012-0086985 (published on August 06, 2012) Korean Patent Publication No. 10-2012-0088342 (published on August 08, 2012)

It is an object of the present invention to provide a defoaming device capable of removing bubbles in a liquid and a diagnostic reagent application device capable of uniformly applying a diagnostic reagent on the membrane using the defoaming device.

According to an aspect of the present invention, there is provided a defoaming apparatus including a container, a partition for dividing an inner space of the container into a first space and a second space, And a vacuum pump connected to the second space. At this time, liquid is received in the first space, and at least a part of the partition may be made of a porous material for discharging bubbles in the liquid through the second space.

According to embodiments of the present invention, the first space of the container may have an open top, and the container may further include a cover closing the open top.

According to embodiments of the present invention, the defoaming device may further comprise a dissolved oxygen sensor for measuring the amount of dissolved oxygen in the liquid.

According to embodiments of the present invention, the first space may be provided with vacuum pressure for removing the bubbles.

According to embodiments of the present invention, the first space may be connected to the vacuum pump or a separate second vacuum pump to form the first space into the second vacuum chamber.

According to another aspect of the present invention, there is provided a diagnostic reagent application device comprising: a container; an internal space of the container divided into a first space for accommodating a diagnostic reagent and a second space serving as a vacuum chamber; A nozzle for applying the diagnostic reagent on the membrane, a supply pipe for connecting between the container and the nozzle, and a supply pipe connected to the supply pipe, And a feed pump for feeding through the nozzle. At least a part of the partition may be made of a porous material for discharging bubbles in the diagnostic reagent through the second space.

According to embodiments of the present invention, the first space of the container has an open top, and the container may further include a cover that closes the open top.

According to embodiments of the present invention, the supply pipe may extend through the cover adjacent to the partition.

According to embodiments of the present invention, the diagnostic reagent application device may further include a dissolved oxygen sensor disposed adjacent to the partition to measure the amount of dissolved oxygen in the diagnostic reagent.

According to embodiments of the present invention, the membrane may have a strip shape, and the diagnostic reagent application device may further include a membrane transfer part for transferring the membrane via the lower part of the nozzle.

According to embodiments of the present invention, the diagnostic reagent application device may further include a heater disposed adjacent to the transfer path of the membrane for drying the membrane to which the diagnostic reagent is applied.

According to embodiments of the present invention, the container may be provided with an observation window for checking the amount of the diagnostic reagent accommodated in the first space.

According to embodiments of the present invention, a piston pump may be used as the supply pump.

According to embodiments of the present invention, the first space may be provided with vacuum pressure for removing the bubbles.

According to embodiments of the present invention, the first space may be connected to the vacuum pump or a separate second vacuum pump to form the first space into the second vacuum chamber.

According to embodiments of the present invention as described above, the defoaming device includes a container having an inner space, a partition dividing the inner space into a first space and a second space, and a partition forming the second space into a vacuum chamber A vacuum pump and the like. Particularly, at least a part of the partition may be made of a porous material, and bubbles in the diagnostic reagent accommodated in the first space may be discharged through the partition and the vacuum chamber.

The diagnostic reagent application device including the defoaming device may further include a nozzle connected to the container through a supply pipe and adapted to apply the diagnostic reagent on the membrane, and a nozzle for supplying the diagnostic reagent through the nozzle, As shown in FIG.

Since the bubbles in the diagnostic reagent can be sufficiently removed through the porous partition and the vacuum chamber, the diagnostic reagent can be applied very uniformly on the membrane. As a result, the reliability of the diagnosis using the diagnostic reagent or the judgment of pregnancy can be greatly improved.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic view illustrating a defoaming device and a diagnostic reagent application device including the defoaming device according to an embodiment of the present invention; FIG.
FIG. 2 is a schematic diagram for explaining the defoaming device shown in FIG. 1. FIG.
Figs. 3 and 4 are schematic structural diagrams for describing the supply pump shown in Fig.
5 is a schematic view illustrating a defoaming apparatus according to another embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, the present invention should not be construed as limited to the embodiments described below, but may be embodied in various other forms. The following examples are provided so that those skilled in the art can fully understand the scope of the present invention, rather than being provided so as to enable the present invention to be fully completed.

In the embodiments of the present invention, when one element is described as being placed on or connected to another element, the element may be disposed or connected directly to the other element, . Alternatively, if one element is described as being placed directly on another element or connected, there can be no other element between them. The terms first, second, third, etc. may be used to describe various items such as various elements, compositions, regions, layers and / or portions, but the items are not limited by these terms .

The terminology used in the embodiments of the present invention is used for the purpose of describing specific embodiments only, and is not intended to be limiting of the present invention. Furthermore, all terms including technical and scientific terms have the same meaning as will be understood by those skilled in the art having ordinary skill in the art, unless otherwise specified. These terms, such as those defined in conventional dictionaries, shall be construed to have meanings consistent with their meanings in the context of the related art and the description of the present invention, and are to be interpreted as being ideally or externally grossly intuitive It will not be interpreted.

Embodiments of the present invention are described with reference to schematic illustrations of ideal embodiments of the present invention. Thus, changes from the shapes of the illustrations, e.g., changes in manufacturing methods and / or tolerances, are those that can be reasonably expected. Accordingly, the embodiments of the present invention should not be construed as being limited to the specific shapes of the regions described in the drawings, but include deviations in the shapes, and the elements described in the drawings are entirely schematic and their shapes Is not intended to describe the exact shape of the elements and is not intended to limit the scope of the invention.

FIG. 1 is a schematic diagram for explaining a defoaming device and a diagnostic reagent applying device including the defoaming device according to an embodiment of the present invention, and FIG. 2 is a schematic diagram for explaining a defoaming device shown in FIG. 1 .

1 and 2, a defoaming device 100 according to an embodiment of the present invention may be used to remove bubbles in a liquid. For example, a body fluid such as urine or blood can be used to produce a diagnostic kit used for diagnosing a disease such as hepatitis, diabetes, anemia, hyperlipidemia, AIDS, etc. or pregnancy.

In particular, the diagnostic kit may include a diagnostic strip coated with a diagnostic reagent 10 for diagnosing the disease or pregnancy. Specifically, the diagnostic strip may be attached with a membrane pad coated with the diagnostic reagent 10, and the membrane pad may be obtained by applying the diagnostic reagent to the band-shaped membrane 20 and then cutting the membrane to a predetermined size .

The defoaming device 100 according to an embodiment of the present invention may be used to remove bubbles from the diagnostic reagent 10 and the diagnostic reagent application device 200 may be configured to remove the bubbled diagnostic reagent 10 Can be used for uniform application on the membrane (20).

The defoaming device 100 includes a container 110 having an inner space and a partition 120 for dividing the inner space into a first space 112 and a second space 114, And a vacuum pump 130 connected to the second space 114 to form a vacuum chamber. As an example, the container 110 may be a cylindrical container such as a barrel, a syringe, or the like. However, the shape of the container 110 may be variously changed, so that the scope of the present invention is not limited thereto.

As illustrated, the interior space of the container 110 may be divided into a first space 112 above the partition 120 and a second space 114 below the partition 120, as shown. At this time, the first space 112 may have an open top and the open top may be closed by a cover 116.

According to an embodiment of the present invention, at least a part of the partition 120 may be made of a porous material. Although the entire partition 120 is made of a porous material, as shown in the drawing, a part of the partition 120 may be made of a porous material. As an example, a porous ceramic may be used as the porous material.

The second space 114 may be formed as a vacuum chamber by the vacuum pump 130. The bubbles in the diagnostic reagent 10 may be discharged through the partition 120 formed of the porous material and the vacuum chamber .

Meanwhile, the porosity and pore size of the porous partition 120 and the pressure inside the vacuum chamber can be appropriately adjusted so that only the bubbles are passed through the porous partition 120 and the diagnostic reagent 10 is not passed through the porous partition 120 have.

According to an embodiment of the present invention, the defoaming device 100 may include a dissolved oxygen sensor 140 for measuring the amount of dissolved oxygen in the diagnostic reagent 10, The operation of the vacuum pump 130 can be adjusted based on the dissolved oxygen amount measured by the vacuum pump 130.

The vacuum pump 130 may be connected to the second space 114 through a vacuum line 132 and a pressure control valve 134 and a vacuum gauge 136 may be installed in the vacuum line 132. have.

The diagnostic reagent application device 200 including the defoaming device 100 as described above is configured to dispense the diagnostic reagent 10 on the membrane 20 together with the container 110, the partition 120, the vacuum pump 130, A supply pipe 220 connecting between the container 110 and the nozzle 210 and a supply pipe 220 connected to the supply pipe 220 and connecting the diagnostic reagent 10 to the nozzle 210. [ A feed pump 230 for feeding through the feed pipe 210, and the like.

According to an embodiment of the present invention, the membrane 20 may have a strip shape, and the diagnostic reagent applying device 200 may include a membrane for transporting the membrane 20 via the lower part of the nozzle 210, And may include a transfer unit 240. The membrane transfer unit 240 may include a supply roller 242 and a collection roller 244 and guide rollers 246 for guiding the transfer path of the membrane 20.

Figs. 3 and 4 are schematic structural diagrams for describing the supply pump shown in Fig.

3 and 4, the supply pipe 220 includes a first supply pipe 222 connecting between the container 110 and the supply pump 230, a second supply pipe 222 connecting the supply pump 230 and the nozzle 230, And a second supply pipe 224 connecting between the first supply pipe 210 and the second supply pipe 224. The first supply pipe 222 may extend into the first space 112 through the cover 116 as shown and the end of the first supply pipe 222 may be connected to the porous partition 120 As shown in FIG.

As shown in the figure, the piston pump may be used as the supply pump 230, and the diagnostic reagent 10 may be introduced into the body of the piston pump through the first supply pipe 222 by the descent of the piston , And the elevation of the piston allows the diagnostic reagent 10 to be applied from the body of the piston pump through the nozzle 210 onto the membrane 20. Although not shown in detail, the piston pump includes check valves connected to the first and second supply pipes 222 and 224 for controlling the flow of the diagnostic reagent 10 .

The dissolved oxygen sensor 140 may be provided on the upper surface of the porous partition 120 and / or on the upper surface of the porous partition 120 to more accurately measure the dissolved oxygen amount of the diagnostic reagent 10 provided through the supply pipeline 220. [ And is disposed adjacent to the end of the pipe 222. Although not shown, a transparent observation window (not shown) for checking the amount of the diagnostic reagent 10 accommodated in the first space 112 may be provided in the container 110, A scale (not shown) may be formed on one side so that the amount of the diagnostic reagent 10 can be quantitatively confirmed.

1, the diagnostic reagent application device 200 is disposed adjacent to the transfer path of the membrane 20 between the nozzle 210 and the collection roller 244, and the diagnostic reagent 10 And a heater 250 for drying the applied membrane 20.

As an example, ceramic heaters may be used to dry the membrane 20. In the meantime, although the heaters 250 are disposed on the upper portion and the lower portion of the membrane 20, various types of heaters or ovens can be used, The scope of the present invention is not limited by the configuration.

5 is a schematic view illustrating a defoaming apparatus according to another embodiment of the present invention.

According to another embodiment of the present invention, the first space 112 of the container 110 may be provided with a vacuum pressure for removing air bubbles inside the diagnostic reagent 10. 5, the first space 112 may be sealed by the cover 116, and the first space 112 may be sealed through a second vacuum pipe 133, And may be connected to a second vacuum pump (not shown).

Accordingly, the first space 112 can be formed as a second vacuum chamber by the second vacuum pump, whereby bubbles can be discharged from the diagnostic reagent 10 through the second vacuum chamber. As a result, the bubbles inside the diagnostic reagent 10 can be effectively discharged through the first space 112 and the second space 114.

Alternatively, the first space 112 may be connected to the vacuum pump 130 through the second vacuum pipe 133 and the vacuum pipe 132. That is, the second vacuum pipe 133 may be connected to the vacuum pipe 132.

According to the embodiments of the present invention as described above, the defoaming device 100 includes a container 110 having an inner space, and a container 110 dividing the inner space into a first space 112 and a second space 114 A partition 120, a vacuum pump 130 for forming the second space 114 as a vacuum chamber, and the like. Particularly, at least a part of the partition 120 may be made of a porous material, and bubbles in the diagnostic reagent 10 accommodated in the first space 112 may be discharged through the partition 120 and the vacuum chamber .

The diagnostic reagent application device 200 including the defoaming device 100 is connected to the container 110 through a supply pipe 220 and is configured to apply the diagnostic reagent 10 on the membrane 20 And a supply pump 230 installed in the supply pipe 220 for supplying the diagnostic reagent 10 through the nozzle 210. The supply pipe 230 may be provided in the nozzle 210,

The bubbles in the diagnostic reagent 10 can be sufficiently removed through the porous partition 120 and the vacuum chamber so that the diagnostic reagent 10 can be applied on the membrane 20 very uniformly. As a result, the reliability of the diagnosis using the diagnostic reagent 10 or the judgment of whether or not it is pregnant can be greatly improved.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention as defined by the following claims It can be understood that

10: Diagnostic reagent 20: Membrane
100: defoaming device 110: container
112: first space 114: second space
116: cover 120: partition
130: Vacuum pump 140: Dissolved oxygen sensor
200: Diagnostic reagent dispensing device 210: Nozzle
220: feed pipe 230: feed pump
240: membrane transfer part 250: heater

Claims (15)

Vessel;
A partition dividing the inner space of the container into a first space and a second space; And
And a vacuum pump connected to the second space to form the second space as a vacuum chamber,
Wherein a liquid is received in the first space, and at least a part of the partition is made of a porous material for discharging bubbles in the liquid through the second space. The defoaming device of claim 1, wherein the first space of the container has an open top, and the container further includes a cover that closes the open top. The defoaming device according to claim 1, further comprising a dissolved oxygen sensor for measuring the amount of dissolved oxygen in the liquid. The defoaming device according to claim 1, wherein a vacuum is applied to the first space to remove the bubbles. The defoaming device according to claim 4, wherein the first space is connected to the vacuum pump or a separate second vacuum pump to form the first space as a second vacuum chamber. Vessel;
A partition dividing the inner space of the container into a first space for accommodating the diagnostic reagent and a second space serving as a vacuum chamber;
A vacuum pump connected to the second space;
A nozzle for applying the diagnostic reagent onto the membrane;
A supply pipe connecting between the vessel and the nozzle; And
And a supply pump connected to the supply line for supplying the diagnostic reagent through the nozzle,
Wherein at least a part of the partition is made of a porous material for discharging bubbles in the diagnostic reagent through the second space. 7. The apparatus of claim 6, wherein the first space of the container has an open top and the container further comprises a cover that closes the open top. The diagnostic reagent application device according to claim 7, wherein the supply pipe extends through the cover so as to be adjacent to the partition. 7. The apparatus for applying a diagnostic reagent according to claim 6, further comprising a dissolved oxygen sensor disposed adjacent to the partition and for measuring an amount of dissolved oxygen in the diagnostic reagent. The method of claim 6, wherein the membrane has a strip shape,
Further comprising a membrane transfer section for transferring the membrane via the lower portion of the nozzle. The diagnostic reagent application device according to claim 10, further comprising a heater disposed adjacent to the transfer path of the membrane for drying the membrane to which the diagnostic reagent is applied. The apparatus for applying a diagnostic reagent according to claim 6, wherein the container is provided with an observation window for checking the amount of the diagnostic reagent contained in the first space. 7. The diagnostic reagent application device according to claim 6, wherein the supply pump is a piston pump. 7. The apparatus for applying a diagnostic reagent according to claim 6, wherein vacuum pressure for removing the bubbles is provided in the first space. 15. The apparatus according to claim 14, wherein the first space is connected to the vacuum pump or a separate second vacuum pump to form the first space into a second vacuum chamber.
KR1020140180212A 2014-12-15 2014-12-15 Deaeration apparatus and apparatus for applying diagnostic reagent including the same KR20160072506A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180014519A (en) * 2016-08-01 2018-02-09 주식회사 제타 Apparatus for manufacturing diagnostic cards
KR20190018266A (en) * 2017-08-14 2019-02-22 주식회사 제타 Apparatus for applying liquid material
KR102411807B1 (en) 2022-02-28 2022-06-22 정지혁 Printing Apparatus of Reagent
KR102504988B1 (en) 2022-09-23 2023-03-03 주식회사 비티엠 Apparatus for dipping diagnostic sheet

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120086985A (en) 2011-01-27 2012-08-06 주식회사 엘지생명과학 Diagnostic kit and manufacturing method of the same
KR20120088342A (en) 2011-01-31 2012-08-08 주식회사 엘지생명과학 Diagnostic strip and manufacturing method of the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20120086985A (en) 2011-01-27 2012-08-06 주식회사 엘지생명과학 Diagnostic kit and manufacturing method of the same
KR20120088342A (en) 2011-01-31 2012-08-08 주식회사 엘지생명과학 Diagnostic strip and manufacturing method of the same

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180014519A (en) * 2016-08-01 2018-02-09 주식회사 제타 Apparatus for manufacturing diagnostic cards
KR20190018266A (en) * 2017-08-14 2019-02-22 주식회사 제타 Apparatus for applying liquid material
KR102411807B1 (en) 2022-02-28 2022-06-22 정지혁 Printing Apparatus of Reagent
KR102504988B1 (en) 2022-09-23 2023-03-03 주식회사 비티엠 Apparatus for dipping diagnostic sheet

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