JP5002437B2 - Treatment filtration device and metal ion monitor using the same - Google Patents

Description

  The present invention relates to a treatment filtration device for treating a measurement target substance such as a metal ion contained in a sample solution to produce a solid compound such as a metal complex, and filtering the solid compound, and a metal ion using the treatment filtration device. It concerns the monitor.

  Conventionally, as a method for measuring a trace amount of metal ions, for example, as shown in Patent Document 1, a sample solution containing metal ions is manually adjusted with a neutralizer to a pH near neutrality, using a pipette, a syringe, or the like. There is a method in which the color is adjusted by reacting with a reagent for aggregating the metal complex.

  Furthermore, there is one that determines the concentration of metal ions in a sample solution by the color of the metal complex and its concentration by filtering the metal complex with a filter.

  However, in order to measure metal ions, a highly corrosive chemical solution such as strong alkali or strong acid may be used, and it is extremely dangerous to manually operate this chemical solution.

  For example, if the sample solution is strongly alkaline, a strongly acidic chemical solution will be used as the neutralizing agent, and there is a risk of heat generation and bumping in the neutralization operation. Is dangerous.

Furthermore, when the metal complex is filtered on the filter, it is desirable to pass it at a predetermined flow rate, but it is difficult to perform this manually using a syringe or the like.
Japanese Patent Laid-Open No. 06-230002

  Therefore, the present invention has been made to solve the above-mentioned problems all at once. For example, even when a highly corrosive chemical solution is used, the measurement target substance is processed safely and easily, and the process is performed. The main intended task is to filter the solid compounds.

That is, the processing filtration apparatus according to the present invention supplies a sample liquid containing a measurement target substance, a mixing chamber into which a processing liquid for generating a solid compound from the measurement target substance is injected, and the processing liquid to the mixing chamber. A processing liquid supply path, a processing liquid quantitative mechanism using a pump that is provided in the processing liquid supply path and is capable of rotating the forward and reverse rotations to inject the processing liquid into the mixing chamber, the sample liquid, and the processing A filter chamber containing a filter for filtering the solid compound from the liquid mixture, a communication passage communicating the mixing chamber and the filter chamber, and a filter downstream of the filter chamber, and passed through the filter. A filtrate discharge passage for discharging the filtrate to the outside; and the filtrate discharge passage, which sucks the mixed liquid and draws the fill from the mixing chamber. Lead to the chamber, the mixing and suction pump for passing the filter liquid, and a control unit for controlling the pump and the suction pump of the treatment liquid quantifying mechanism, the filter upstream of the filter chamber, and the filtrate A bypass path communicating with the upstream side of the suction pump in the discharge path or the downstream side of the filter in the filter chamber; and an on-off valve provided on the bypass path and controlled by the control device to open and close the bypass path. The control device opens the on-off valve, sucks air from the bypass passage by the suction pump, stores the mixed liquid from the mixing chamber to the filter upstream side of the filter chamber, and then opens and closes the opening / closing. The valve is closed and the mixed liquid stored on the upstream side of the filter is filtered by the suction pump. Characterized in that that.

If this is the case, the sample liquid and the treatment liquid can be automatically mixed, and the operator does not need manual work using a pipette, syringe, or the like during the mixing process, thus improving safety. be able to. In addition, it is possible to prevent a processing error due to an error such as a processing procedure or an injection amount. Furthermore, since it is possible to perform filtration at an appropriate flow rate by controlling the suction pump with the control device, it is possible to reliably deposit the solid compound on the filter. Therefore, safe and reproducible processing and filtration can be easily performed. Furthermore, after filtration starts, it can prevent that air mixes in a filter and can prevent that filtration stops by mixing of air.

  In order to prevent the liquid injected into the mixing chamber from flowing into the filter chamber through the communication path before mixing in the mixing chamber, the communication path receives the suction force of the suction pump. It is desirable that the mixed liquid is caused to flow from the mixing chamber to the filter chamber.

  Further, it is desirable that the control device opens the on-off valve, sends air to the mixing chamber via the bypass passage by the suction pump, and bubbles the liquid mixture to stir. In this case, a dedicated stirring device can be dispensed with, and the device configuration can be simplified.

  It can be suitably used when the substance to be measured is a metal ion and the solid compound is a metal complex.

  Moreover, the processing filtration apparatus of this invention can be used suitably for the metal ion monitor which measures the density | concentration of the metal ion contained in a sample liquid.

  As described above, according to the present invention, for example, even when a highly corrosive chemical solution is used, it is possible to safely and easily treat a substance to be measured and filter a solid compound generated by the treatment.

  Next, an embodiment of a metal ion monitor using the processing filtration apparatus according to the present invention will be described with reference to the drawings.

<Device configuration>
The metal ion monitor 1 according to the present embodiment agglomerates a metal complex of metal ions by mixing a sample liquid containing metal ions and a treatment liquid, and separates the metal complex on the filter F. The metal ion concentration is measured by determining the color of the metal complex and its concentration.

  The treatment liquid of this embodiment contains a neutralizing agent for neutralizing the sample liquid (in this embodiment, an acidic solution (for example, nitric acid)) and a pH indicator for determining whether or not the sample liquid has been neutralized. It is a reagent for aggregating a buffer and a complex of metal ions.

  Specifically, as shown in FIG. 1, this includes a mixing chamber 2, a buffer solution supply path 3, a neutralizing agent supply path 4, a reagent supply path 5, a filter chamber 6, a mixing chamber 2 and a filter. A communication path 7 communicating with the chamber 6, a filtrate discharge path 8 provided in the filter chamber 6, a suction pump P <b> 3 provided in the filtrate discharge path 8, and a control device 9 are provided.

  Each part 2-9 is demonstrated below.

  In the mixing chamber 2, a sample solution, a neutralizing agent, a buffer solution and a reagent are injected, and these liquids are mixed to generate a mixed solution. Specifically, the mixing chamber 2 is formed of a transparent material so that the color of the liquid mixture inside can be visually recognized. Thereby, it can be confirmed by the color of the liquid mixture by a pH indicator whether the sample liquid was neutralized with the neutralizing agent.

  In addition, a sample port (not shown) through which a sample liquid can be quantitatively injected by a pipette or the like is provided at the upper part of the mixing chamber 2.

  The buffer solution supply path 3 communicates the buffer solution tank 10 containing the buffer solution with the mixing chamber 2 and supplies the buffer solution from the buffer solution tank 10 into the mixing chamber 2. In FIG. 1, reference numeral 101 denotes an air hole provided in the buffer solution tank 10.

  Further, the mixing chamber side opening of the supply path 3 opens downward in the upper part (for example, the upper wall) of the mixing chamber 2. Further, the buffer solution supply path 3 is provided with a buffer solution metering mechanism A1 for metering the buffer solution into the mixing chamber 2.

  The neutralizing agent supply path 4 communicates the neutralizing agent tank 11 containing the neutralizing agent with the mixing chamber 2, and supplies the neutralizing agent from the neutralizing agent tank 11 into the mixing chamber 2. In FIG. 1, reference numeral 111 denotes an air hole provided in the neutralizer tank 11.

  And the neutralizing agent supply path 4 is comprised with the tube which has a light transmittance. In addition, the mixing chamber side opening of the supply path 4 opens downward in the upper part of the mixing chamber 2. Further, the neutralizer supply path 4 is provided with a neutralizer quantitative mechanism A2 for quantitatively injecting the neutralizer and injecting it into the mixing chamber 2.

  The reagent supply path 5 communicates the reagent tank 12 containing the reagent with the mixing chamber 2 and supplies the reagent from the reagent tank 12 into the mixing chamber 2. In FIG. 1, reference numeral 121 denotes an air hole provided in the reagent tank 12.

  In addition, the mixing chamber side opening of the supply path 5 opens downward in the upper part of the mixing chamber 2. Further, the reagent supply path 5 is provided with a reagent quantitative mechanism A3 for quantitatively injecting the reagent into the mixing chamber 2.

  And the buffer solution supply path 3 and the reagent supply path 5 of this embodiment are made to merge downstream by the manifold block MB, and a part of flow path is made common.

Specifically, the buffer solution supply path 3 includes a manifold block MB, a buffer solution pipe H1 that connects the buffer solution tank 10 and the manifold block MB, and a supply tube H2 that connects the manifold block MB and the mixing chamber 2. Has been. The reagent supply path 5 includes a manifold block MB, a reagent pipe H3 that connects the reagent tank 12 and the manifold block MB, and a supply pipe H2 that connects the manifold block MB and the mixing chamber 2.

  The manifold block MB includes an internal flow path MB1 that communicates with the buffer pipe H1, the reagent pipe H3, and the supply pipe H2, a first on-off valve V1 that is provided in the internal flow path MB1 that communicates with the buffer pipe H1, and a reagent. A second opening / closing valve V2 provided in the internal flow path MB1 communicating with the piping and a third opening / closing valve V3 provided in the internal flow path MB1 communicating with the supply piping 32 are provided. In the present embodiment, electromagnetic valves are used as the first on-off valve V1, the second on-off valve V2, and the third on-off valve V3. Further, the manifold block MB is formed with an internal flow path MB1 that communicates a branch path A11 and supply paths 3 and 5, which will be described later.

  The filter chamber 6 accommodates a filter F that filters the metal complex from a mixed solution including a sample solution, a neutralizing agent, a buffer solution, and a reagent, and is provided below the mixing chamber 2. The filter chamber 6 holds the filter F so that all of the liquid mixture flowing into the filter chamber 6 passes through the filter F.

  Further, the filter chamber 6 is provided with an open / close door (not shown) for attaching and removing the filter F. The filter chamber 6 is sealed in a state where the open / close door is closed. Further, in the filter chamber 6, a communication path 7 is opened above the portion where the filter F is installed (upstream side of the filter F). Further, in the filter chamber 6, a filtrate discharge path 8 is opened at a lower portion (downstream side of the filter F) where the filter F is installed.

  The filter F filters the liquid mixture and separates the metal complex in the liquid mixture, and has a filtration accuracy capable of separating the metal complex from the liquid mixture.

  The communication path 7 communicates the lower part of the mixing chamber 2 and the upstream side of the filter F in the filter chamber 6, and one end is connected to the lower end of the mixing chamber 2 and the other end is connected to the upper end of the filter chamber 6. The connecting pipe H4.

  The communication path 7 allows the mixed liquid to flow from the mixing chamber 2 to the filter chamber 6 by a suction force from the outside (suction pump P3). That is, the connecting pipe H4 has an inner diameter that does not allow the liquid to pass through unless the surface tension of the liquid acts and receives an external suction force. Thereby, it is possible to prevent the sample solution, neutralizing agent, buffer solution, reagent and the mixed solution composed of them injected into the mixing chamber 2 from flowing into the filter chamber 6 without permission. Therefore, the liquid can be prevented from leaking into the filter chamber 6 before being mixed, for example, before the metal complex is generated, and the process for generating the metal complex can be reliably performed. .

  The filtrate discharge path 8 is provided on the downstream side of the filter F in the filter chamber 6 and discharges the filtrate that has passed through the filter F to the drainage tank 13.

  The suction pump P3 is a pump provided in the filtrate discharge path 8 and capable of rotating in the forward and reverse directions. In the present embodiment, a tube pump (also referred to as a peristaltic pump) is used. This tube pump has a supply / discharge tube made of a flexible material, and a rotor having a plurality of rollers on the outer circumferential side in the circumferential direction and sequentially pressing the tube while moving along the longitudinal direction of the supply / discharge tube. It is to be prepared. The tube pump rotates by rotating the rotor, while the roller rotates while crushing the supply / discharge tube to push out the fluid inside the supply / discharge tube, while the portion crushed by the roller of the supply / discharge tube is restored. When returning to the original shape, the next fluid is sucked by the suction pressure generated in the supply / discharge tube. The tube pump has a pump function of suction and discharge by continuously performing this operation.

  The suction pump P3 sucks the mixed liquid and guides it from the mixing chamber 2 to the filter chamber 6 through the communication path 7. Further, the mixed liquid in the filter chamber 6 is sucked through the filtrate discharge path 8 so that the mixed liquid on the filter F passes through the filter F.

  The control device 9 receives detection signals from sensors A11, A21, A22 and a pressure gauge 14, which will be described later, and controls the tube pumps P1 to P3 and the on-off valves V1 to V4. A general-purpose or dedicated computer comprising a CPU (not shown), an internal memory, an external memory (not shown), an input / output interface, a communication interface, an AD converter, an input means such as a keyboard and a touch panel, and an output means such as a display and a printer. is there.

  And the control apparatus 9 performs drive control of each tube pump P1-P3 or open / close control of each on-off valve V1-V4 by being operated by the operator or automatically. The function of the control device 9 will be described below as appropriate.

  It should be noted that it may be configured so as to fulfill the functions of the respective units only with an analog circuit without using a CPU, or a part of the functions may be shared with an external personal computer or the like. Alternatively, it may be composed of a plurality of devices connected to each other by wire or wireless.

<Quantitative mechanism>
Next, the quantitative mechanisms A1 to A3 provided in the supply paths 3, 4, and 5 will be described together with the function of the control device 9.

  The buffer solution quantification mechanism A1 and the reagent quantification mechanism A3 of this embodiment are made common by using the manifold block MB.

  That is, the buffer quantification mechanism A1 and the reagent quantification mechanism A3 of the present embodiment, as shown in FIG. 1, include a branch path A11 that is branched from the supply paths 3 and 5 by the manifold block MB, and the branch path A11. A level sensor A12 that is provided above and measures the liquid volume from the branch point C, and a tube pump P1 that is a pump capable of forward and reverse rotation provided on the downstream side of the level sensor A12 in the branch path A11.

  The level sensor A12 detects the presence or absence of liquid in the branch path A11. In this embodiment, a light transmission type photo interrupter is used.

  The branch path A11 is constituted by a tube having optical transparency. Further, the branch path A11 communicates with the mixing chamber 2. Thereby, even when the tube pump P1 sucks the buffer solution or the reagent too much, the liquid only flows into the mixing chamber 2, and the safety of the apparatus 1 can be ensured. Contamination due to leakage to the outside can be prevented.

  Next, a buffer solution metering method using the buffer solution metering mechanism A1 will be described together with the function of the control device 9.

  When the buffer solution is quantified and injected into the mixing chamber 2, the controller 9 first opens the first on-off valve V1 in the manifold block MB, and closes the second on-off valve V2 and the third on-off valve V3. And the control apparatus 9 attracts | sucks the air in the branched path A11 by rotationally driving the tube pump P1. Then, the buffer solution is sucked from the buffer solution tank 11, and the buffer solution flows into the branch path A11. Thereafter, the control device 9 rotationally drives the tube pump P1 until a predetermined amount of buffer solution is determined based on the detection signal from the level sensor A12.

  After quantifying a predetermined amount by the level sensor A12, the control device 9 closes the first on-off valve V1 and the second on-off valve V2, and opens the third on-off valve V3. And the control apparatus 9 sends out the buffer solution attracted | sucked in the branch path A11 by reversely driving the tube pump P1. Then, the quantified buffer solution is injected into the mixing chamber 2.

  Note that, in the reagent quantitative injection method using the reagent quantitative mechanism A3, the first on-off valve V1 and the second on-off valve V2 are simply switched.

  As shown in FIGS. 1 and 2, the neutralizing agent quantification mechanism A2 includes a tube pump P2 that is a pump provided in the neutralizing agent supply passage 4 and capable of rotating in the forward and reverse directions, and a downstream side of the tube pump P2. It consists of an upstream flow path sensor A21 and a downstream flow path sensor A22 that are spaced apart in the flow path direction.

  The flow path sensors A21 and A22 detect the presence or absence of liquid in the neutralizing agent supply path 4 composed of a tube, and in this embodiment, a light transmission type photo interrupter is used.

  A method for quantitatively injecting a neutralizing agent using the neutralizing agent quantitative mechanism A2 will be described with reference to FIG.

When the controller 9 rotates the tube pump P2 at the time of constant injection, the neutralizing agent is sucked from the neutralizing agent tank 11 and passes through the upstream flow path sensor A21 and the downstream flow path sensor A22. At this time, the control device 9 receives the detection signals from the respective flow path sensors A21 and A22, and measures the flow time T until the neutralizing agent reaches the downstream flow path sensor A22 from the upstream flow path sensor A21. To do.

  And the control apparatus 9 calculates the liquid flow rate (V / T) by the tube pump P2 from the capacity | capacitance (V) which can accommodate the liquid of the neutralizing agent supply path 4 between the distribution time T and flow path sensors A21 and A22. calculate.

  Based on the capacity (V ′) from the downstream flow path sensor A22 to the container-side opening of the supply path 4 and the liquid flow velocity (V / T), the control device 9 determines that the neutralizing agent has passed through the downstream flow path sensor A22. The driving time of the tube pump P2 after passing is set, and the neutralizing agent injected into the mixing chamber 2 is quantified. The capacity (V) between the flow path sensors A21 and A22 and the capacity (V ') from the downstream flow path sensor A22 to the container side opening of the supply path 4 are input to the control device 9 and stored in advance. .

  In addition, after the metering of the neutralizing agent, the control device 9 drives the tube pump P2 to rotate in reverse, sucks the neutralizing agent in the neutralizing agent supply path 4, and supplies the neutralizing agent to the upstream flow path sensor. Pull to the upstream side of A21. As a result, it is possible to prevent the neutralizing agent remaining in the front end opening (mixing chamber side opening) of the supply path 4 from being inadvertently injected into the mixing chamber 2 after the constant injection, and at the next injection. Quantitatively can be injected again.

  In the present embodiment, the flow rate (V / T) of the tube pump P2 is measured for each fixed injection, and the drive time of the tube pump P2 is adjusted.

<Air clogging prevention mechanism>
Therefore, the metal ion monitor 1 of the present embodiment includes an air clogging prevention mechanism Z that prevents air from being clogged in the filter F during filtration.

  As shown in FIGS. 1 and 3, the air clogging prevention mechanism Z includes a bypass passage Z1 provided around the filter F, and a fourth on-off valve V4 provided on the bypass passage Z1. Yes.

  One end of the bypass passage Z1 opens to the upstream side of the filter F in the filter chamber 6, and the other end opens to the upstream side of the suction pump P3 in the filtrate discharge passage 8. A pressure gauge 14 for measuring the pressure in the filtrate discharge path 8 is provided on the bypass path Z1.

  The fourth on-off valve V4 is controlled by the control device 9 to open and close the bypass passage Z1, and in this embodiment, an electromagnetic valve is used.

  The operation of the air clogging prevention mechanism Z configured as described above will be described together with the function of the control device 9.

  The control device 9 opens the fourth on-off valve V4 of the bypass passage Z1, and rotationally drives the suction pump P3. Then, the suction pump P3 discharges air from the filtrate discharge path 8. At this time, since the pressure deficiency in the flow path of the bypass passage Z1 is smaller than the pressure deficiency in the flow path in which the filter F is interposed, air on the upstream side of the filter F in the filter chamber 6 is sucked from the bypass path Z1. . Since the filter chamber 6 is sealed, the liquid mixture flows into the filter chamber 6 from the mixing chamber 2 by the amount of air sucked.

  When the suction pump P3 is rotationally driven for a predetermined time, a predetermined amount of the liquid mixture is stored from the mixing chamber 2 to the filter F upstream side of the filter chamber 6.

  At this time, the mixed liquid stored on the upstream side of the filter F is set to be lower than the opening position of the bypass passage Z1 in the filter chamber 6. Thereby, it can prevent that a liquid mixture flows in into bypass channel Z1.

  Thereafter, the control device 9 closes the fourth on-off valve V4 and rotationally drives the suction pump P3. Then, the downstream side of the filter F becomes a suction pressure, and the liquid mixture stored on the upstream side of the filter F passes through the filter F.

  If the mixed liquid on the upstream side of the filter F is filtered and reduced, the space on the upstream side of the filter F becomes a suction pressure, and the mixed liquid flows into the filter chamber 6 from the mixing chamber 2 through the communication path 7.

  Next, a method of stirring the liquid mixture in the mixing chamber 2 using the air clogging prevention mechanism Z will be described together with the function of the control device 9.

  The control device 9 operates the fourth on-off valve V4 and the tube pump P3 during each mixing (mixing of the sample solution and the buffer solution, mixing of the sample solution and the neutralizing agent, and mixing of the sample solution and the reagent). Then, air is sent from the lower part of the mixing chamber 2, and the liquid mixture is bubbled to perform stirring.

  Specifically, at the time of constant injection, the fourth on-off valve V4 is opened, the tube pump P3 is driven to rotate in reverse, air is sent to the mixing chamber 2 via the bypass passage Z1, and mixing consisting of a sample solution, a reagent, etc. Bubble the liquid and stir.

<Operation of this embodiment>
Next, the operation and operation method of the metal ion monitor 1 of the present embodiment will be described.

  The operator opens the opening / closing door of the filter chamber 6 and installs the filter F. Then, a certain amount of sample solution is injected from the sample port provided in the upper part of the mixing chamber 2 using a pipette or the like. At this time, a predetermined amount of sample powder may be put into the mixing chamber 2 and a predetermined amount of water may be quantitatively injected using a pipette or the like.

  Next, when a measurement start button (not shown) is pressed, the buffer solution containing the pH indicator is quantified by the buffer solution quantitative mechanism A1 and automatically injected into the mixing chamber 2 from the buffer solution supply path 3.

  Next, the operator uses an input means such as a touch panel of the control device 9 to quantify the neutralizing agent with the neutralizing agent quantifying mechanism A2 until the sample solution has an appropriate pH, and the neutralizing agent supply path 4. Into the mixing chamber 2. At this time, it can be confirmed by visually observing the color of the mixed solution by the pH indicator that the mixed solution comprising the sample solution and the neutralizing agent has an appropriate pH.

  After the pH adjustment, when the operator presses a reagent injection button on the touch panel of the control device 9, the reagent is quantified by the reagent quantification mechanism A3 and injected into the mixing chamber 2 from the reagent supply path 5. Thereby, the metal complex of the metal ion which exists in a sample liquid is produced | generated.

  In each mixing, the suction pump P3 and the fourth open / close valve V4 are operated to feed air from the lower portion of the mixing chamber 2 and perform bubbling to perform stirring.

  After a predetermined amount of time has passed since the reagent has been injected, the fourth on-off valve V4 is opened with the metal complex formed, and the suction pump P3 is rotationally driven to suck the air upstream of the filter F in the filter chamber 6. Thus, a predetermined amount of the liquid mixture is stored upstream of the filter F. At this time, in order to store a predetermined amount of the mixed liquid, the driving time of the tube pump P3 can be set in advance, or after the operator confirms the storage of the predetermined amount, the operator operates the touch panel to operate the suction pump. P3 can also be stopped.

  Then, after a predetermined amount of the mixed liquid is stored, when the fourth on-off valve V4 is closed and the suction pump P3 is driven to rotate, the mixed liquid stored on the upstream side of the filter F passes through the filter F. At this time, the metal complex is collected and deposited on the filter F.

  Then, the filtrate that has flowed to the downstream side of the filter F flows out into the drainage tank 13 through the filtrate discharge path 8 that opens at the lower portion of the filter chamber 6. On the other hand, when the mixed liquid passes through the filter F, the upstream side of the filter F in the filter chamber 6 becomes a suction pressure, and the mixed liquid flows in from the mixing chamber 2 correspondingly.

  When the mixed liquid disappears on the upstream side of the filter F, the filter F containing moisture does not pass air, so the pressure gauge 14 provided on the downstream side of the fourth on-off valve of the filtrate discharge path 8 or the bypass path Z1. Pressure value changes rapidly. The control device 9 that has received the detection signal of the pressure gauge 14 determines that the filtration of the mixed liquid has ended, and stops the suction pump P3. Thereby, filtration of a liquid mixture is complete | finished.

  After the filtration, the operator takes out the filter F from the filter chamber 6, visually determines the color of the metal complex deposited on the filter F and the concentration thereof with a visual sensor or a color sensor, and the concentration of metal ions in the sample liquid. Determine.

<Effect of this embodiment>
According to the metal ion monitor 1 of the present embodiment configured as described above, the sample solution and the processing solution (buffer solution, neutralizing agent, and reagent) can be automatically mixed. Since the treatment liquid is not touched directly, safety can be improved.

  In addition, the sample liquid and the processing liquid can be automatically mixed, and a processing error due to an error such as a processing procedure or an injection amount can be prevented.

  When the mixed solution is filtered, it is necessary to keep filtering at an appropriate flow rate in order to deposit the metal complex on the filter F, but it is difficult to perform this process manually. However, according to this embodiment, it is possible to perform filtration at an appropriate flow rate by controlling the suction pump P3 by the control device 9, so that metal ions can be reliably deposited on the filter F. Therefore, safe and reproducible processing and filtration can be easily performed.

  In addition, since the air clogging prevention mechanism Z is provided, it is possible to prevent filtration from being stopped due to air clogging on the filter F during filtration. In addition, since the liquid mixture in the mixing chamber 2 is bubbled using the air clogging prevention mechanism Z, it is possible to perform measurement with better reproducibility.

<Other modified embodiments>
The present invention is not limited to the above embodiment. In the following description, the same reference numerals are given to members corresponding to the above-described embodiment.

  For example, as shown in FIG. 4, the configuration of the buffer quantification mechanism A1 or the reagent quantification mechanism A3 can be the same as the configuration of the neutralizing agent quantification mechanism A2. In this case, the configuration of the supply paths 3, 4, and 5 can be simplified, the number of on-off valves can be reduced, and the device 1 can be made inexpensive.

  Further, as shown in FIG. 4, the bypass path Z <b> 1 may communicate the upstream side of the filter F in the filter chamber 6 and the downstream side of the filter F in the filter chamber 6. In this case, since the wet filter F does not allow air to pass, filtrate that cannot be discharged accumulates on the upstream side of the pump P3 in the filtrate discharge path 8, but this can be suitably prevented. In this case, after the value of the pressure gauge provided on the filtrate discharge passage becomes large, the control device 9 opens the fourth on-off valve V4 and sucks it through the bypass passage Z1. Further, the air in the filter chamber 6 and the filter F can be dried by flowing air from the mixing chamber to the filter F upstream side of the filter chamber 6 and the filter F downstream side of the filter chamber 6 through the bypass Z1. Thereby, the filter F on which the metal complex is deposited can be taken out without polluting the surroundings.

  As shown in FIG. 4, the pressure sensor 14 may not be provided in the filtrate discharge path 8, and the flow path sensor 15 may be provided in the communication path 7. In this case, it can be seen from the detection signal from the flow path sensor 15 that the mixed liquid has disappeared in the mixing chamber 2. At this time, the control device 9 can measure the time from the start of filtration until the mixed liquid in the mixing chamber runs out, calculate the remaining filtration time, and drive-control the suction pump P3.

  Furthermore, it is desirable that the filter chamber 6 of the above embodiment is provided with an open / close sensor for monitoring the opening / closing of the door. The control device 9 can prevent liquid from being injected into the filter chamber 6 when the door is open based on the detection signal from the open / close sensor.

  In addition, the progress status of each process can be notified to the worker by sound or voice, and the progress status can be displayed on the screen of the control device 9 or the like.

In addition, for example, a pack used for infusion or the like can be used for the reagent tank 12 or the like. In this case, the air vent hole is not necessary, and the configuration of the apparatus 1 can be simplified. .

  In addition, in the above embodiment, the concentration of metal ions is measured visually or based on the output of the color sensor. However, the control device 9 receives the output signal from the color sensor and uses it as the detection signal. Based on this, the concentration of metal ions may be calculated. This makes it possible to automatically measure the concentration of metal ions.

  In addition, as shown in FIG. 5, a liquid inflow prevention structure K that prevents liquid from flowing into the pressure gauge 14 may be provided between the pressure gauge 14 and the bypass passage Z <b> 1 or the filtrate discharge passage 8. The liquid inflow prevention structure K includes a chamber K1 having a liquid storage portion and an air storage portion for storing air in the upper portion of the liquid storage portion, and a connection path for connecting the air storage portion and the pressure gauge in the chamber K1. It consists of K2. Thereby, it can prevent that a liquid flows into the pressure gauge 14, and the pressure gauge 14 for gas can be used.

  In addition, some or all of the above-described embodiments and modified embodiments may be combined as appropriate, and the present invention is not limited to the above-described embodiments, and various modifications can be made without departing from the spirit of the present invention. .

The schematic block diagram of the metal ion monitor which concerns on one Embodiment of this invention. The schematic diagram which shows the neutralizing agent fixed_quantity | assay mechanism of the embodiment. The schematic diagram which shows the air clogging prevention mechanism of the embodiment. The schematic block diagram of the metal ion monitor which concerns on other deformation | transformation embodiment. The partial block diagram of the metal ion monitor which concerns on other deformation | transformation embodiment.

1 ... Metal ion monitor (processing filtration device)
2 ... Mixing chamber 3 ... Buffer supply path 4 ... Neutralizer supply path 5 ... Reagent supply path A1 ... Buffer quantification mechanism A2 ... Neutralizer quantification mechanism A3 Reagent quantitative mechanism 6 ... filter chamber 7 ... communication passage 8 ... filtrate discharge passage F ... filters P1, P2, P3 ... pump (tube pump)
Z1 ... Bypass passages V1, V2, V3, V4 ... Open / close valve 9 ... Control device

Claims (5)

A sample chamber containing a measurement target substance, and a mixing chamber into which a processing liquid for generating a solid compound from the measurement target substance is injected;
A treatment liquid supply path for supplying the treatment liquid to the mixing chamber;
A treatment liquid quantitative mechanism using a pump provided in the treatment liquid supply path and capable of rotating in a forward and reverse direction to inject the treatment liquid into the mixing chamber;
A filter chamber containing a filter for filtering the solid compound from a mixed solution comprising the sample solution and the treatment solution;
A communication path communicating the mixing chamber and the filter chamber;
A filtrate discharge passage that is provided on the filter downstream side of the filter chamber and discharges the filtrate that has passed through the filter to the outside;
A suction pump that is provided in the filtrate discharge path, sucks the mixed liquid, leads the mixed liquid from the mixing chamber to the filter chamber, and allows the mixed liquid to pass through the filter;
A control device for controlling the pump of the processing liquid quantitative mechanism and the suction pump;
A bypass path communicating with the filter upstream side in the filter chamber and the suction pump upstream side in the filtrate discharge path or the filter downstream side in the filter chamber;
An on-off valve that is provided on the bypass path and is controlled by the control device to open and close the bypass path,
The control device opens the on-off valve, sucks air from the bypass passage by the suction pump, stores the mixed liquid from the mixing chamber to the filter upstream side of the filter chamber, and then opens the on-off valve. The processing filtration apparatus which closes and filters the liquid mixture stored on the upstream side of the filter by the suction pump .   The processing filtration apparatus according to claim 1, wherein the communication path is configured to flow the mixed liquid from the mixing chamber to the filter chamber by receiving a suction force of the suction pump. The processing filtration device according to claim 1 or 2 , wherein the control device opens the on-off valve, sends air to the mixing chamber through the bypass passage by the suction pump, and bubbles the mixed solution to stir. The analyte is a metal ion, the solid compound processing filtering device according to claim 1, 2 or 3 wherein the metal complex. A metal ion monitor using the processing filtration device according to claim 4 .