KR20160038132A - Acne treatment composition and method for manufacturing acne treatment preparation using the same - Google Patents
Acne treatment composition and method for manufacturing acne treatment preparation using the same Download PDFInfo
- Publication number
- KR20160038132A KR20160038132A KR1020140130028A KR20140130028A KR20160038132A KR 20160038132 A KR20160038132 A KR 20160038132A KR 1020140130028 A KR1020140130028 A KR 1020140130028A KR 20140130028 A KR20140130028 A KR 20140130028A KR 20160038132 A KR20160038132 A KR 20160038132A
- Authority
- KR
- South Korea
- Prior art keywords
- alcohol
- oil
- group
- composition
- acne
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y40/00—Manufacture or treatment of nanostructures
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Abstract
A composition for treating acne and a method for producing an acne treatment agent using the composition are disclosed. One embodiment of the present invention is a composition for treating acne comprising a nano-ion complex for photodynamic therapy comprising a copolymer of a hydrophilic cationic polymer and a photosensitizer combined and a conjugate of an anionic substrate polymer and a photoinitiator, Is a polyethylene glycol-polyethyleneimine-pheophorbide A, and the conjugate is a chondroitin sulfate-blackhole quencher (BHQ). In the 100 g of the composition for treating acne, Is greater than 0 and less than or equal to 1 milligram.
Description
One embodiment of the present invention relates to a composition for treating acne and a method for producing an acne treatment agent using the same.
Although skin diseases do not interfere with life, they occur frequently, and modern people are becoming more and more common due to various causes, climate, and stress.
In particular, acne is an intractable skin disease caused by fungal and bacterial infections, which requires a long term treatment period and is difficult to treat.
As a method for treating acne, hormones and antibiotics for suppressing sebum production are prescribed. These methods are somewhat effective in the prevention and treatment of acne, but side effects are questioned in terms of satisfactory efficacy and skin safety.
In the case of hormone drugs, it may cause adverse effects in long-term administration such as erythema and dryness of skin. Antibiotics such as benzoyl peroxide and retinoic acid cause problems of carcinogenicity and contact dermatitis have. In addition, tetracyclin, erythromycin, and clindamycin have been used for the treatment of acne, but it has been reported that there is a possibility of the occurrence of resistant bacteria.
On the other hand, photodynamic therapy (PDT) is a curative method such as a chemotherapeutic agent that can treat lesions without surgery using a photosensitizer with selectivity and photosensitivity to various lesions. For example, the photo-sensitive material is administered to a subject by intravenous injection, and a suitable light is irradiated to activate the photo-sensitive substance to convert oxygen molecules into singlet oxygen or to create new radicals The lesion is selectively attacked and collapsed.
As such photosensitizers, porphyrin compounds are representative, and porphyrin compounds extracted from dips, mulberry leaves, and green algae have spectroscopic properties suitable for use as photosensitizers, and red light having a relatively high cell permeability (700-900 nm) is known to be capable of efficiently generating the electron transferring property and thus the excited state.
An embodiment of the present invention is to provide a composition for treating acne which is harmless to the human body and does not cause side effects, and a method for producing an acne treatment agent using the same.
Also, one embodiment of the present invention is to provide a composition for treating acne including a photosensitizing substance having optical properties and disease target characteristics, and a method for producing an acne treatment agent using the same.
One embodiment of the present invention is a composition for treating acne comprising a nano-ion complex for photodynamic therapy comprising a copolymer of a hydrophilic cationic polymer and a photosensitizer combined and a conjugate of an anionic substrate polymer and a photoinitiator, Wherein the cohesion is polyethylene glycol-polyethyleneimine-pheophorbide A, and the conjugate is a chondroitin sulfate-blackhole quencher (BHQ), and the photodynamic therapy nano ion Wherein the amount of the complex is greater than 0 and less than 1 milligram.
Wherein the composition for treating acne comprises 0.1-10 wt% of an emulsifier, 0.1-10 wt% of a primary alcohol, 0.1-10 wt% of a secondary alcohol, 0.1-10 wt% of a fatty acid, 1-40 wt% of an oil, .
The emulsifier may be a nonionic surfactant having a structure of hydroxyl group (-OH), ether group (-O-), amide group (-CONH) and ester group (-COO-) in the molecule. Polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide and propylene oxide block copolymer, polymeric surfactant of alkyl acrylate copolymer; Lecithin, lanolin, cholesterol, natural surfactants of saponin, and the like.
The first alcohol may be at least one selected from the group consisting of glycerin, propylene glycol, butyleneglycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof.
The second alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, arachidonyl An alcohol, an alcohol, an alcohol, or a combination thereof.
The fatty acid may be at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, or a combination thereof.
Wherein the oil is selected from the group consisting of cyclodymethicone, dimethicone, diethylhexylcarbonate, hydrogenated polyhedrin, isopropyl myristate, liquid paraffin, vegetable squalane, macadamia nut oil, jojoba oil, avocado oil, olive oil, camellia oil, And combinations thereof.
According to another embodiment of the present invention, there is provided a method for producing an acne remedy comprising the above-mentioned composition for treating acne, comprising the steps of: preparing an aqueous raw material by heating an emulsifier, a first alcohol, and purified water; Heating the first alcohol, fatty acid, and oil to produce an oily raw material; Mixing the heated water raw material and the oil raw material; Neutralizing and cooling the mixture; And a step of homogenizing the cooled mixture with a nanotechnology complex for photodynamic therapy.
According to one embodiment of the present invention, there is provided a composition for treating acne which is harmless to the human body and does not cause side effects, and a method for producing an acne treatment agent using the same.
According to an embodiment of the present invention, there is provided a composition for treating acne which is applicable to photodynamic therapy (PDT) including a photosensitizing substance having optical characteristics and disease target characteristics, and a method for producing an acne treatment agent using the composition .
Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited thereto, and the present invention is only defined by the scope of the following claims.
One embodiment of the present invention is a composition for treating acne comprising a nano-ion complex for photodynamic therapy comprising a copolymer of a hydrophilic cationic polymer and a photosensitizer combined and a conjugate of an anionic substrate polymer and a photoinitiator, Wherein the cohesion is polyethylene glycol-polyethyleneimine-pheophorbide A, and the conjugate is a chondroitin sulfate-blackhole quencher (BHQ), and the photodynamic therapy nano ion Wherein the amount of the complex is greater than 0 and less than 1 milligram.
The hydrophilic cationic polymer is selected from the group consisting of glycol chitosan, chitosan, poly-L-lysine (PLL), poly-beta-amino ester polymer, polyethyleneimine (PEI), polyamidoamine (PAMAM) dendrimer, , And the hydrophilic cationic polymer can form an ion complex nanoparticle by an electrostatic attraction with an anionic substrate polymer to be described later.
For example, the hydrophilic cationic polymer may include polyethylene glycol and polyethyleneimine.
At this time, the polyethylene glycol (PEG) has a structural formula represented by HO- (CH 2 CH 2 O) nH, and in this case, due to the structural characteristic of ethylene oxide ((CH 2 CH 2 O) -) It shows strong hydrophilicity. In addition, when such a property is combined with a protein or a compound, it has a characteristic of giving biocompatibility.
Also, polyethylene glycol is present in the form of methoxypolyethylene glycol (mPEG) in which one end is substituted with a methoxy group (CH 3 O-), and its structural formula is represented by CH 3 O- (CH 2 CH 2 O) n H do. Particularly, in the case of a preparation having a form of polyethylene glycol-protein, most methoxypolyethylene glycol derivatives are used as polyethylene glycol. This is because the terminal of the polyethylene glycol is protected by a methoxy group, so that the stability of the structure can be maintained.
In one embodiment of the present invention, the polyethylene glycol may be a polyethylene glycol having a terminal carboxyl group with a molecular weight of 300 to 50,000. Also, the polyethylene glycol may be methoxypolyethylene glycol having one terminal substituted with a methoxy group.
On the other hand, the polyethyleneimine is a cationic polymer electrolyte which has been used for a long time in the field of paper making. In general, polyethylene imine is divided into linear and branched depending on its structure, and the synthesis methods of the two are different. Commonly used polyethyleneimine is branched, and the number of primary amines, secondary amines, and tertiary amines is present in a ratio of 1: 2: 1. It is known that one branch of the branched polyethyleneimine exists in the range of about 3 to 3.5 of the main chain nitrogen atoms. Such polyethyleneimine is soluble in water, alcohol, glycol, dimethylformamide, tetrahydrofuran, It is known that it is not soluble in high molecular weight hydrocarbons, oleic acid and diethyl ether.
For example, the polyethyleneimine may be a branched polyethylenimine having no toxicity. When the molecular weight of the polyethyleneimine is less than 100, the copolymer produced according to the present invention can not bind to a useful physiologically active substance and has a molecular weight of 25,000 , There is a problem that it is difficult to be discharged from the body through the kidney in the body. Therefore, the polyethyleneimine may have a molecular weight of 100 to 25,000, preferably 100 to 2000.
The photosensitizer may be selected from the group consisting of a phorphyrins compound, a chlorins compound, a bacteriochlorins compound, a phthalocyanine compound, a naphthalocyanines compound, and a 5- 5-aminoevuline esters) compounds may be used. For example, the photosensitizer may be Chlorin e6, Zinc Phthalocyanine, or pheophorbide A.
The complex is formed in the form that the quencher is bonded to the anionic substrate polymer.
More specifically, the anionic substrate polymer is selected from the group consisting of chondroitin-6-sulfate (C6S), heparan sulfate (HS), heparan sulfate proteoglycan (HSPG), heparin, chondroitin- C6S), dermatan sulfate (DS), keratan sulfate (KS), and hyaluronic acid (HA).
The quencher may be selected from the group consisting of a blackhole quencher (BHQ), a blackberry quencher (BBQ), and derivatives thereof.
Accordingly, in the present invention, the cationic polymer, that is, the hydrophilic cationic polymer is used to impart hydrophilicity to the photosensitizer having hydrophobicity, so that it is well dissolved in a solution or water during optical treatment, so that no precipitate is formed.
Meanwhile, the composition for treating acne according to an embodiment of the present invention comprises 0.1 to 10% by weight of an emulsifier; 0.1-10% by weight of primary alcohol; 0.1 to 10% by weight of a secondary alcohol; 0.1-10% by weight fatty acid; 1-40% by weight of oil; And a purified water of the remaining amount. When the content of the emulsifier, the first and second alcohols, the fatty acid, the oil, and the purified water is in the above range, the effect of the acne remedy using the composition for treating acne can be further improved.
More specifically, the emulsifier is a nonionic surfactant having a structure of a hydroxyl group (-OH), an ether group (-O-), an amide group (-CONH) and an ester group (-COO-) in the molecule. Polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide and propylene oxide block copolymer, polymeric surfactant of alkyl acrylate copolymer; Lecithin, lanolin, cholesterol, natural surfactants of saponin, and the like.
The first alcohol may be at least one selected from the group consisting of glycerin, propylene glycol, butyleneglycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof.
The second alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, arachidonyl An alcohol, an alcohol, an alcohol, or a combination thereof.
The fatty acid may be at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, or a combination thereof.
Wherein the oil is selected from the group consisting of cyclodymethicone, dimethicone, diethylhexylcarbonate, hydrogenated polyhedrin, isopropyl myristate, liquid paraffin, vegetable squalane, macadamia nut oil, jojoba oil, avocado oil, olive oil, camellia oil, And combinations thereof.
Another embodiment of the present invention is a method for producing an acne remedy comprising the above-mentioned composition for treating acne, comprising the steps of: preparing an aqueous raw material by heating an emulsifier, a first alcohol, and purified water; Heating the first alcohol, fatty acid, and oil to produce an oily raw material; Mixing the heated water raw material and the oil raw material; Neutralizing and cooling the mixture; And a step of homogenizing the cooled mixture with a nanotechnology complex for photodynamic therapy.
In still another embodiment of the present invention, there is provided a therapeutic agent for acne, which is an emulsion, gel, liquid, or powder, as an acne remedy prepared according to the above-described method for producing an acne remedy.
Hereinafter, examples and comparative examples of the present invention will be described. However, the following examples are only illustrative of the present invention and are not intended to limit the scope of the present invention.
Example
Example One: Emulsion type Manufacture of acne remedy
1. Preparation of nano-ion complex
1-1. Synthesis of Copolymer (Polyethylene Glycol-Polyethyleneimine-Photo Sensitive Agent)
After the reflux condenser was installed, 10 g of methoxypolyethylene glycol (mPEG-COOH) (Sigma, 5000 Da) was dissolved in 50 ml of methylene chloride (CHCl 2 ) using a 250 ml flask. Thereafter, the imide was added to 0.52 g of N-hydroxysuccinimide and 0.74 g of dicycloheta, followed by reaction at room temperature for 20 hours. Dicyclohexylurea was removed through a filter process and then precipitated in diethylether to obtain an activated form of polyethylene glycol (mPEG-NHS).
2 g of the obtained polyethylene glycol was dissolved in 200 ml of chloroform. Thereafter, 0.5g of polyethyleneimine (Alfa Aesar, 1800da) was dissolved in 50ml of chloroform, and then the polyethylene glycol dissolved in the solution was dropped one by one to perform covalent bonding reaction of polyethylene glycol and polyethyleneimine.
The reaction was carried out for 24 hours. After completion of the reaction, the reaction mixture was concentrated to a total volume of 30 ml using a vacuum concentrator, and then precipitated in diethyl ether to obtain a covalent bond of polyethylene glycol and polyethyleneimine .
1 g of the obtained polyethylene glycol-polyethyleneimine (mPEG-PEI) was dissolved in a mixture of pheophorbide A (eq, 0.07 mmol), dicyclohexyl carbodiimide (DCC) (1.2 * pheophorbide A in moles) N-hydroxysuccinimide (HOSu) was dissolved in 20 ml of dimethyl sulfoxide (DMSO) and stirred for 3 hours. Thereafter, the two solutions were mixed and reacted at room temperature for 24 hours. After dialyzing with primary distilled water for 2 days using a dialysis membrane (Spectra / Por; mol. Wt. Cutoff size, 1,000), the final reaction product was freeze-dried to obtain polyethylene glycol-polyethyleneimine- Pheophorbide A copolymer was obtained.
1-2. Synthesis of conjugate (quencher conjugated chondroitin sulfate)
0.1 g of chondroitin sulfate was dissolved in 20 ml of distilled water. After dissolving BHQ3 in dried DMSO, N- (3-dimethylaminopropyl) -N'-ethylcarbodiimine hydrochloride (EDC) and 4-dimethylaminopyridine (DMAP) were added at a ratio of 1.5 times with respect to the molar ratio of BHQ . Then, the two solutions were stirred at room temperature for 3 hours, and then mixed and reacted for 24 hours. The removal of the unreacted quencher (BHQ3) was removed by dialysis using primary distilled water for 2 days using a dialysis membrane (Spectra / Por, mol. Wt. Cutoff size, 1,000) Lt; / RTI > to yield a quencher conjugated chondroitin sulfate conjugate.
1-3. Synthesis of Copolymers and Conjugates
1-1. The polyethylene glycol-polyethyleneimine-pheophorbide A copolymer and the quencher-conjugated chondroitin sulfate conjugate prepared in 1-2. Were dissolved in the tertiary distilled water, respectively, and the mass ratio of the polyethylene glycol-polyethyleneimine-pheophorbide A copolymer was 1.0: 0.3, 1.0: 0.6, 1.0: 1.2, 1.0: 2.5, and 1.0: 5.0. After 2 hours, the mixture was filtered using a 0.8 mu m syringe filter to produce a nano-ion complex.
2. Mixing raw materials
Each of the phases was heated to 80 DEG C to dissolve the emulsifier, the polyhydric alcohol, the higher fatty acid and the oil as an oil phase, using purified water, glycerin, and raw materials as the water phase according to the composition shown in Table 1 below. The water phase or the oil phase was slowly added to the oil phase and uniformly mixed with a mixer and emulsified at 80 ° C for 10 minutes. The emulsion was neutralized with a pH adjuster at 70 DEG C or lower and then cooled to 45 DEG C to obtain a mixture of raw materials.
3. Manufacture of acne remedy
The nano-ion complex prepared by the above-mentioned process was added to the mixture of the raw materials obtained by cooling to 45 ° C as shown in Table 1 below, and homogenized to prepare an emulsion-type acne remedy.
Example 2: Gel type Manufacture of acne remedy
Except that purified water, glycerin, a hydrophilic polymer compound, and ethanol were heated to 40 ° C and dispersed in water phase according to the composition of the following [Table 2] to prepare a mixture of raw materials. .
Example 3: Preparation of liquid type acne remedy
A liquid type acne remedy was prepared in the same manner as in Example 1, except that a mixture of raw materials was prepared from purified water, polyhydric alcohol and ethanol as aqueous phase according to the composition shown in the following [Table 3].
Example 4: Preparation of powder acne remedy
A liquid type acne remedy was prepared in the same manner as in Example 1, except that Starch or dextrin or glucose was used as an excipient according to the composition shown in the following [Table 4] and homogenized by impregnation with a polyhydric alcohol and a nano- Respectively.
It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims. As will be understood by those skilled in the art. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.
Claims (8)
The copolymer is polyethylene glycol-polyethyleneimine-pheophorbide A,
The conjugate is a chondroitin sulfate-blackhole quencher (BHQ)
Wherein the photomechanical treatment nano-ion complex is contained in an amount of more than 0 and less than 1 milligram per 100 grams of the composition for treating acne.
Wherein the composition for treating acne comprises 0.1-10 wt% of an emulsifier, 0.1-10 wt% of a primary alcohol, 0.1-10 wt% of a secondary alcohol, 0.1-10 wt% of a fatty acid, 1-40 wt% of an oil, 0.0 > (I) < / RTI >
The emulsifier may be a nonionic surfactant having a structure of hydroxyl group (-OH), ether group (-O-), amide group (-CONH) and ester group (-COO-) in the molecule. Polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide and propylene oxide block copolymer, polymeric surfactant of alkyl acrylate copolymer; Lecithin, lanolin, cholesterol, and natural surfactants of saponin.
Wherein the first alcohol is at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof.
The second alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, arachidonyl Wherein the composition is at least one selected from the group consisting of alcohol, erucyl alcohol, and combinations thereof.
Wherein the fatty acid is at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, or a combination thereof.
Wherein the oil is selected from the group consisting of cyclodymethicone, dimethicone, diethylhexylcarbonate, hydrogenated polyhedrin, isopropyl myristate, liquid paraffin, vegetable squalane, macadamia nut oil, jojoba oil, avocado oil, olive oil, camellia oil, Wherein the composition is at least one selected from the group consisting of a combination of acne and acne.
Heating the emulsifier, the primary alcohol, and the purified water to prepare an aqueous phase raw material;
Heating the first alcohol, fatty acid, and oil to produce an oily raw material;
Mixing the heated water raw material and the oil raw material;
Neutralizing and cooling the mixture; And
Homogenizing the cooled mixture with a nanomechanical complex for photodynamic therapy
≪ / RTI >
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140130028A KR101622545B1 (en) | 2014-09-29 | 2014-09-29 | Acne treatment composition and method for manufacturing acne treatment preparation using the same |
| PCT/KR2014/009145 WO2016052775A1 (en) | 2014-09-29 | 2014-09-30 | Composition for treating acne, and method for producing therapeutic agent for acne using same |
| CN201480072497.6A CN105899206A (en) | 2014-09-29 | 2014-09-30 | Composition for treating acne, and method for producing therapeutic agent for acne using same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020140130028A KR101622545B1 (en) | 2014-09-29 | 2014-09-29 | Acne treatment composition and method for manufacturing acne treatment preparation using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160038132A true KR20160038132A (en) | 2016-04-07 |
| KR101622545B1 KR101622545B1 (en) | 2016-05-20 |
Family
ID=55630793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020140130028A KR101622545B1 (en) | 2014-09-29 | 2014-09-29 | Acne treatment composition and method for manufacturing acne treatment preparation using the same |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR101622545B1 (en) |
| CN (1) | CN105899206A (en) |
| WO (1) | WO2016052775A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511622A (en) * | 2016-11-04 | 2017-03-22 | 深圳市婴缘健康有限公司 | Infant wound repair ointment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101308507B1 (en) * | 2011-07-07 | 2013-09-17 | (주)비알뷰티플레볼루션 | Acne therapeutics and sebum secernent inhibitor which comprise tryptophan, and kits for photodynamic therapy containing the same |
| KR101336501B1 (en) * | 2011-09-28 | 2013-12-03 | 가톨릭대학교 산학협력단 | Nano ion-complex for photodynamic theraphy comprising hydrophile cationic polymer photosensitizer derivatives and anionic polysaccharide quencher derivatives |
| KR20140014443A (en) * | 2012-07-24 | 2014-02-06 | 국립암센터 | Graphene oxide-photosensitizers complex containing disulfide linker and composition for diagonosis and therapy of canncer using the same |
| KR20140035565A (en) * | 2012-09-14 | 2014-03-24 | 동성제약주식회사 | Chlorin e6 for the treatment, prevention or improvement of acne |
-
2014
- 2014-09-29 KR KR1020140130028A patent/KR101622545B1/en active IP Right Grant
- 2014-09-30 CN CN201480072497.6A patent/CN105899206A/en active Pending
- 2014-09-30 WO PCT/KR2014/009145 patent/WO2016052775A1/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| CN105899206A (en) | 2016-08-24 |
| WO2016052775A1 (en) | 2016-04-07 |
| KR101622545B1 (en) | 2016-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101736149B1 (en) | Dry multiple encapsulated composition containing photosensitizer for improvement of a pimpled skin and preparation thereof | |
| Zhang et al. | Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy | |
| JP4745664B2 (en) | Polymer derivatives of camptothecins | |
| KR101444274B1 (en) | Block copolymer for drug complex and pharmaceutical composition | |
| KR101336501B1 (en) | Nano ion-complex for photodynamic theraphy comprising hydrophile cationic polymer photosensitizer derivatives and anionic polysaccharide quencher derivatives | |
| JP2008534747A (en) | PEG-polyacetal graft copolymer and PEG-polyacetal-POE graft copolymer and pharmaceutical composition | |
| Wu et al. | Regulating the bacterial oxygen microenvironment via a perfluorocarbon-conjugated bacteriochlorin for enhanced photodynamic antibacterial efficacy | |
| CN113663079B (en) | Carrier-free self-assembly nano particle and preparation method and application thereof | |
| US20090130033A1 (en) | Dendrimer-Aminobuadiene-Based Uv Screens | |
| JP2024054248A (en) | Hyaluronic acid derivatives, pharmaceutical compositions and hyaluronic acid derivative-drug conjugates | |
| Ravichandran et al. | Polysorbate surfactants as drug carriers: Tween 20-Amphotericin B conjugates as anti-fungal and anti-leishmanial agents | |
| KR20070122522A (en) | Peg-poly(ortho ester) graft copolymers and pharmaceutical compositions | |
| WO2016038595A1 (en) | Micelar delivery system based on enzyme-responsive amphiphilic peg-dendron hybrid | |
| EP1865988A2 (en) | Peg-polyacetal diblock and triblock copolymers and pharmaceutical compositions | |
| CN110790922B (en) | Preparation method and application of polyporphyrin compound | |
| Wu et al. | A polyamidoamine (PAMAM) derivative dendrimer with high loading capacity of TLR7/8 agonist for improved cancer immunotherapy | |
| Lu et al. | Facile synthesis of chitosan-based nanogels through photo-crosslinking for doxorubicin delivery | |
| KR101622545B1 (en) | Acne treatment composition and method for manufacturing acne treatment preparation using the same | |
| KR101622544B1 (en) | Athlete's foot treatment composition and method for manufacturing athlete's foot treatment preparation using the same | |
| CN110511299B (en) | Phthalocyanine-carboxymethyl chitosan conjugate and preparation method and application thereof | |
| KR101736147B1 (en) | Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof | |
| WO2020047418A1 (en) | Cyanine-based telodendrimers and uses for treating cancer | |
| KR101323102B1 (en) | Nanoparticles formed by encapsulating an anticancer drug into glycolchitosan-cholanic acid complex and a process for the preparation thereof | |
| KR102104943B1 (en) | Polymeric conjugates for polysaccharide-based photodynamic therapy and uses thereof | |
| CN110339368B (en) | Preparation method of reduction-responsive targeting polyethylene glycol-polycarbonate maytansine prodrug micelle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A201 | Request for examination | ||
| E902 | Notification of reason for refusal | ||
| E90F | Notification of reason for final refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| FPAY | Annual fee payment |
Payment date: 20190510 Year of fee payment: 4 |