KR101736147B1 - Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof - Google Patents
Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof Download PDFInfo
- Publication number
- KR101736147B1 KR101736147B1 KR1020150137654A KR20150137654A KR101736147B1 KR 101736147 B1 KR101736147 B1 KR 101736147B1 KR 1020150137654 A KR1020150137654 A KR 1020150137654A KR 20150137654 A KR20150137654 A KR 20150137654A KR 101736147 B1 KR101736147 B1 KR 101736147B1
- Authority
- KR
- South Korea
- Prior art keywords
- alcohol
- group
- foot
- athlete
- acid
- Prior art date
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A61K47/48192—
-
- A61K47/48946—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
Abstract
The present invention relates to a dry multiple capsule-like composition containing a photosensitizing substance for the improvement of athlete's foot and a process for producing the same.
The composition of the present invention can be applied to photodynamic therapy (PDT) including a photosensitizing substance that is harmless to the human body and does not cause side effects and has optical characteristics and disease target characteristics.
Further, the composition of the present invention is excellent in improving the athlete's foot.
Description
The present invention relates to a dry multiple capsule-like composition containing a photosensitizing substance for the improvement of athlete's foot and a process for producing the same.
Although skin diseases do not interfere with life, they occur frequently, and modern people are becoming more and more common due to various causes, climate, and stress.
Athlete's foot is the most common type of skin disease caused by fungi. Trichophyton fungus, a fungus, damages the skin by parasitic on wet part of skin, overlapping part of skin, stratum corneum, etc. A lot of athlete's foot occurs mainly in the blue and elderly people, and narrow and tight shoes, sneakers, and excessive sweat cause the disease.
When athlete's foot develops, it is characterized by itching and pain usually between toes, and excretion of excretion (ammonia compound) after ingesting nutrients from skin cells generates severe odor.
In addition, it spreads to various parts of the body (hands, feet, toes, claws, fingernails, palms, groin) accompanied by small edema and rashes, and infected parts are generally whiter and almost odorous.
Athlete's foot treatment requires at least 2 months to 1 year of long-term treatment, is difficult to cure, and is easy to recur, so it is known that the fundamental therapeutic effect is important. In addition, as a side effect of long-term treatment of athlete's foot, there are many side effects such as hepatotoxicity, and therefore, there is a need to develop a new athlete's remedy without side effects.
On the other hand, photodynamic therapy (PDT) is a curative method such as a chemotherapeutic agent that can treat lesions without surgery using a photosensitizer with selectivity and photosensitivity to various lesions. For example, the photo-sensitive material is administered to a subject by intravenous injection, and a suitable light is irradiated to activate the photo-sensitive substance to convert oxygen molecules into singlet oxygen or to create new radicals The lesion is selectively attacked and collapsed.
As such photosensitizers, porphyrin compounds are representative, and porphyrin compounds extracted from dips, mulberry leaves, and green algae have spectroscopic properties suitable for use as photosensitizers, and red light having a relatively high cell permeability (700-900 nm) is known to be capable of efficiently generating the electron transferring property and thus the excited state.
In the current technology, the active material, which is a photosensitive material, is added to a liquid or an emulsion or stabilized in a liposome form using a phospholipid to maintain the stability of the active material for a long period of time. However, The process of making liposome using phospholipid is also complicated and expensive, and the yield of production is also low, which is inefficient because of the problem of the present technology It is pointed out.
In order to compensate for the disadvantages of such liposome-type carriers, powdered dry multiple capsules may be used. However, conventional dry multi-capsules are stable in powder form, but when they are mixed with liquid, they swell themselves to break capsules, There is a disadvantage that it is mixed with powder and liquid phase in use because of the disadvantage that the efficacy substance which is present is excreted and denatured.
Accordingly, it is an object of the present invention to provide a dry multiple capsule-type composition which is not broken even in a liquid phase and can be conveniently used because of its ease of mixing with a liquid phase during use, and a method for producing the same.
More specifically, the present invention provides a dry multiple capsule-like composition containing a photosensitizing substance for improving athlete's foot and a method for producing the same.
It is another object of the present invention to provide a method for producing athlete's foot remedy comprising the dry multiple capsule-type composition for improving athlete's foot.
The present invention relates to a dry multiple capsule-type composition for improving athlete's foot comprising an ionic complex comprising a copolymer of a hydrophilic cationic polymer and a photosensitizer and a conjugate of an anionic substrate polymer and a photoinitiator.
The present invention also provides a method for preparing a pharmacologically active agent for improving athlete's foot, comprising the steps of: preparing primary particles of polysaccharide by using ethanol or purified water as a dispersion medium; Preparing a secondary particle by heating a group consisting of a primary alcohol, a secondary alcohol, a fatty acid, a polysaccharide, a gum, a titanium oxide and a zinc oxide, or a combination thereof, with ethanol or purified water as a dispersion medium; And a method for producing an improving agent.
The composition of the present invention is applicable to photodynamic therapy (PDT) of athlete's foot including a photosensitizing substance which is harmless to the human body and does not cause side effects and has optical characteristics and disease target characteristics.
In addition, the composition of the present invention is excellent in improving athlete's foot.
1 is a schematic view of a dry multiple capsule-type composition for improving athlete's foot according to the present invention.
FIG. 2 is a photograph of a dry multiple capsule-type composition for improving athlete's foot according to the present invention by an optical microscope 200 times.
Fig. 3 shows a dry multiple capsule-type composition for improving athlete's foot according to the present invention, wherein (a) the capsule has a diameter of 1.0 mm and (b) the capsule has a diameter of 0.1 mm.
The present invention relates to a dry multiple capsule-type composition for improving athlete's foot comprising an ionic complex comprising a copolymer of a hydrophilic cationic polymer and a photosensitizer and a conjugate of an anionic substrate polymer and a photoinitiator.
The hydrophilic cationic polymer may be selected from the group consisting of glycol chitosan, chitosan, poly-L-lysine (PLL), poly-beta-amino ester polymer, polyethyleneimine (PEI), polyamidoamine (PAMAM) Dendrimers, and derivatives thereof.
For example, the hydrophilic cationic polymer may include polyethylene glycol and polyethyleneimine.
At this time, the polyethylene glycol (PEG) has a structural formula represented by HO- (CH 2 CH 2 O) nH, and in this case, due to the structural characteristic of repeatedly connected ethylene oxide ((CH 2 CH 2 O) -) Lt; / RTI >
In addition, when such a property is combined with a protein or a compound, it has a characteristic of giving biocompatibility.
Also, polyethylene glycol is present in the form of methoxypolyethylene glycol (mPEG) in which one end is substituted with a methoxy group (CH 3 O-), and its structural formula is represented by CH 3 O- (CH 2 CH 2 O) n H do.
In particular, in the case of a preparation having a form of polyethylene glycol-protein, most methoxypolyethylene glycol derivatives are used as polyethylene glycol. This is because the terminal of the polyethylene glycol is protected by a methoxy group, so that the stability of the structure can be maintained.
In one embodiment of the present invention, the polyethylene glycol may be a polyethylene glycol having a terminal carboxyl group with a molecular weight of 300 to 50,000. Also, the polyethylene glycol may be methoxypolyethylene glycol having one terminal substituted with a methoxy group.
On the other hand, the polyethyleneimine is a cationic polymer electrolyte which has been used for a long time in the field of paper making. In general, polyethylene imine is divided into linear and branched depending on its structure, and the synthesis methods of the two are different.
Commonly used polyethyleneimine is branched, and the number of primary amines, secondary amines, and tertiary amines is present in a ratio of 1: 2: 1.
It is known that one branch of the branched polyethyleneimine exists for every 3 to 3.5 of the main chain nitrogen atoms. Such polyethyleneimine is soluble in water, alcohol, glycol, dimethylformamide, tetrahydrofuran, esters, It is known that it is not soluble in high molecular weight hydrocarbons, oleic acid and diethyl ether.
For example, the polyethyleneimine may be a branched polyethylenimine having no toxicity. When the molecular weight of the polyethyleneimine is less than 100, the copolymer produced according to the present invention can not bind to a useful physiologically active substance and has a molecular weight of 25,000 , There is a problem that it is difficult to be discharged from the body through the kidney in the body.
Therefore, the polyethyleneimine may have a molecular weight of 100 to 25,000, preferably 100 to 2000.
The hydrophilic cationic polymer can form ionic complex particles by electrostatic attraction with the anionic substrate polymer described below.
In the present invention, the photosensitizer is preferably selected from the group consisting of a phorphyrins compound, a chlorins compound, a bacteriochlorins compound, a phthalocyanine compound, a naphthalocyanines compound, Compounds selected from the group consisting of 5-aminoevuline esters compounds can be used.
For example, the photosensitizer may be Chlorin e6, Zinc Phthalocyanine, or pheophorbide A.
In the present invention, the copolymer may be polyethylene glycol-polyethyleneimine-pheophorbide A.
Also, in the present invention, the combination may be formed in a form in which a quencher is combined with an anionic substrate polymer.
More specifically, the anionic substrate polymer is selected from the group consisting of chondroitin-6-sulfate (C6S), heparan sulfate (HS), heparan sulfate proteoglycan (HSPG), heparin, chondroitin- C6S), dermatan sulfate (DS), keratan sulfate (KS), and hyaluronic acid (HA).
In the present invention, the quencher may be selected from the group consisting of a blackhole quencher (BHQ), a blackberry quencher (BBQ), and derivatives thereof. Preferably a black hole quencher.
Accordingly, in the present invention, the cationic polymer, that is, the hydrophilic cationic polymer is used to impart hydrophilicity to the photosensitizer having hydrophobicity, so that it is well dissolved in a solution or water during optical treatment, so that no precipitate is formed.
In the present invention, the conjugate may be a chondroitin sulfate-blackhole quencher (BHQ).
In the present invention, the ion complex may be used in an amount of more than 0 to 100 mg based on 100 g of the total composition.
Also, in the present invention, the capsule is not limited thereto, but it may be spherical, and the diameter may be more than 0 mm and less than 10 mm.
The composition may also comprise 0.1-10% by weight of an emulsifier, 0.1-10% by weight of a primary alcohol, 0.1-10% by weight of a secondary alcohol, 0.1-10% by weight of fatty acids, 1-40% by weight of polysaccharides, titanium oxide or zinc oxide 1 -40% by weight of water, 1 to 10% by weight of gum, and a remaining amount of purified water.
When the content of the emulsifier, the first and second alcohols, the fatty acid, the polysaccharide, the titanium oxide or the zinc oxide, the gourd, and the purified water is in the above-mentioned range, the athlete's foot improving effect can be further improved.
The emulsifier may be a nonionic surfactant having a structure of hydroxyl group (-OH), ether group (-O-), amide group (-CONH) and ester group (-COO-) in the molecule. Polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide and propylene oxide block copolymer, polymeric surfactant of alkyl acrylate copolymer; Lecithin, lanolin, cholesterol, natural surfactants of saponin, and the like.
The first alcohol may be at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof.
The second alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, arachidonyl At least one selected from the group consisting of alcohol, ethersyl alcohol, and combinations thereof.
The fatty acid may be at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, or a combination thereof.
The polysaccharide may be at least one selected from the group consisting of corn starch, potato starch, sweet potato starch, cellulose, dextrin, glucose, sucrose, mannitol, or a combination thereof.
The gum may be at least one selected from the group consisting of carrageenan gum, guar gum, alginic acid, sodium alginate, agar, and combinations thereof as the water-soluble polymer.
The present invention also provides a method for producing athlete's foot remedy comprising the dry multiple capsule-type composition for improving athlete's foot, comprising the steps of: preparing primary particles of polysaccharide with ethanol or purified water as a dispersion medium; Preparing a secondary particle by heating a group consisting of a primary alcohol, a secondary alcohol, a fatty acid, a polysaccharide, a gum, and titanium oxide or zinc oxide singly or in combination thereof to form secondary particles using ethanol or purified water as a dispersion medium; And a method for producing an improving agent.
And coating the secondary particles with a hydrophilic polymer or a lipophilic polymer.
The hydrophilic polymer may be a carbomer, hydroxyethyl cellulose or carrageenan gum, and the oleophilic polymer may be a shellac or a silicone powder.
The polysaccharide for producing the primary particles may be at least one selected from the group consisting of corn starch, potato starch, sweet potato starch, cellulose, dextrin, glucose, sucrose, mannitol or a combination thereof.
The first alcohol for producing the secondary particles may be at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof. have.
The second alcohol for producing the secondary particles is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, At least one selected from the group consisting of ricinoleyl alcohol, arachidonyl alcohol, erucyl alcohol, and combinations thereof.
The fatty acid for producing the secondary particles may be at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, and combinations thereof.
The polysaccharide for producing the secondary particles may be at least one selected from the group consisting of corn starch, potato starch, sweet potato starch, cellulose, dextrin, glucose, sucrose, mannitol or a combination thereof.
The gum for producing the secondary particles may be at least one selected from the group consisting of carrageenan gum, guar gum, alginic acid, sodium alginate, agar, and combinations thereof as the water-soluble polymer.
Hereinafter, embodiments of the present invention will be described in detail. However, the present invention is not limited thereto, and the present invention is only defined by the scope of the following claims.
< Example >
1. Preparation of ion complexes
1-1. Copolymer ( Polyethylene glycol - Polyethylene imine - Photo sensation agent ) Synthesis of
After the reflux condenser was installed, 10 g of methoxypolyethylene glycol (mPEG-COOH) (Sigma, 5000 Da) was dissolved in 50 ml of methylene chloride (CHCl 2 ) using a 250 ml flask.
Thereafter, the imide was added to 0.52 g of N-hydroxysuccinimide and 0.74 g of dicycloheta, followed by reaction at room temperature for 20 hours. Dicyclohexylurea was removed through a filter process and then precipitated in diethylether to obtain an activated form of polyethylene glycol (mPEG-NHS).
2 g of the obtained polyethylene glycol was dissolved in 200 ml of chloroform. Thereafter, 0.5g of polyethyleneimine (Alfa Aesar, 1800da) was dissolved in 50ml of chloroform, and then the polyethylene glycol dissolved in the solution was dropped one by one to perform covalent bonding reaction of polyethylene glycol and polyethyleneimine.
The reaction was carried out for 24 hours. After completion of the reaction, the reaction mixture was concentrated to a total volume of 30 ml using a vacuum concentrator, and then precipitated in diethyl ether to obtain a covalent bond of polyethylene glycol and polyethyleneimine Respectively.
1 g of the obtained polyethylene glycol-polyethyleneimine (mPEG-PEI) was dissolved in a mixture of pheophorbide A (eq, 0.07 mmol), dicyclohexyl carbodiimide (DCC) (1.2 * pheophorbide A in moles) N-hydroxysuccinimide (HOSu) was dissolved in 20 ml of dimethyl sulfoxide (DMSO) and stirred for 3 hours. Thereafter, the two solutions were mixed and reacted at room temperature for 24 hours.
After dialyzing with primary distilled water for 2 days using a dialysis membrane (Spectra / Por; mol. Wt. Cutoff size, 1,000), the final reaction product was freeze-dried to obtain polyethylene glycol-polyethyleneimine- Pheophorbide A copolymer was obtained.
1-2. concrete( Quencher Junction chondroitin Sulfate ) Synthesis of
0.1 g of chondroitin sulfate was dissolved in 20 ml of distilled water. After dissolving BHQ3 in dried DMSO, N- (3-dimethylaminopropyl) -N'-ethylcarbodiimine hydrochloride (EDC) and 4-dimethylaminopyridine (DMAP) were added at a ratio of 1.5 times with respect to the molar ratio of BHQ .
Then, the two solutions were stirred at room temperature for 3 hours, and then mixed and reacted for 24 hours. The removal of the unreacted quencher (BHQ3) was removed by dialysis using primary distilled water for 2 days using a dialysis membrane (Spectra / Por, mol. Wt. Cutoff size, 1,000) Lt; / RTI > to yield a quencher conjugated chondroitin sulfate conjugate.
1-3. Synthesis of Copolymers and Conjugates
1-1. The polyethylene glycol-polyethyleneimine-pheophorbide A copolymer and the quencher-conjugated chondroitin sulfate conjugate prepared in 1-2. Were dissolved in the tertiary distilled water, respectively, and the mass ratio of the polyethylene glycol-polyethyleneimine-pheophorbide A copolymer was 1.0: 0.3, 1.0: 0.6, 1.0: 1.2, 1.0: 2.5, and 1.0: 5.0. After 2 hours, the mixture was filtered using a 0.8 μm syringe filter to prepare an ion complex.
2. Dry multiple capsule type Preparation of athlete's foot remedy comprising composition
Saccharose and hydroxyethyl cellulose were dispersed in ethanol or purified water as a dispersion medium to prepare primary particles and emulsifier, lecithin, mannitol, fatty acid, hydroxypropyl starch phosphate, gum and titanium oxide were heated to disperse ethanol or purified water To prepare secondary particles, and then, the secondary particles prepared were coated with a hydrophilic polymer or lipophilic polymer to form tertiary particles.
The following Table 1 relates to compositions of athlete's foot improving agents comprising dry multiple capsule-like compositions.
Primary coating
Secondary coating
Tertiary coating
※ Dispersing agent is volatile and not included in the total amount.
It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the following claims and their equivalents. It will be understood that the invention may be practiced. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.
Claims (14)
Wherein the copolymer is polyethylene glycol-polyethyleneimine-pheophorbide A and the conjugate is a chondroitin sulfate-blackhole quencher (BHQ)
Wherein the capsule is spherical and has a diameter ranging from greater than 0 mm to less than 10 mm. The dry multiple capsule-type composition for improving athlete's foot comprising the ion complex.
Wherein the ion complex is present in an amount of more than 0 to 100 mg based on 100 g of the total composition.
Wherein the composition comprises from 0.1 to 10% by weight of an emulsifier, from 0.1 to 10% by weight of a primary alcohol, from 0.1 to 10% by weight of a secondary alcohol, from 0.1 to 10% by weight of a fatty acid, from 1 to 40% by weight of a polysaccharide, By weight, gum, 1-10% by weight of gum, and a remaining amount of purified water.
The emulsifier may be a nonionic surfactant having a structure of hydroxyl group (-OH), ether group (-O-), amide group (-CONH) and ester group (-COO-) in the molecule. Polyoxyethylene type, polyhydric alcohol ester type, ethylene oxide and propylene oxide block copolymer, polymeric surfactant of alkyl acrylate copolymer; Lanolin, lecithin, lanolin, cholesterol, and natural surfactants of saponin. The dry multiple capsule type composition for improving athlete's foot.
Wherein the first alcohol is at least one selected from the group consisting of glycerin, propylene glycol, butylene glycol, dipropylene glycol, polyethylene glycol, sorbitol, and combinations thereof. Dry multiple capsule-like composition.
The second alcohol is selected from the group consisting of lauryl alcohol, cetyl alcohol, stearyl alcohol, cetearyl alcohol, oleyl alcohol, behenyl alcohol, linoleyl alcohol, undecylenyl alcohol, palmitoleyl alcohol, linolenyl alcohol, arachidonyl Wherein the at least one capsule is at least one selected from the group consisting of alcohols, ethers, alcohols, and combinations thereof.
Wherein the fatty acid is at least one selected from the group consisting of stearic acid, lauric acid, myristic acid, behenic acid, isostearic acid, oleic acid, or a combination thereof.
Wherein the polysaccharide is at least one selected from the group consisting of corn starch, potato starch, sweet potato starch, cellulose, dextrin, glucose, sucrose, mannitol, or a combination thereof.
Wherein the gum is at least one selected from the group consisting of carrageenan gum, guar gum, alginic acid, sodium alginate, agar, and combinations thereof as the water-soluble polymer.
Preparing primary particles by using polysaccharide as a dispersion medium of ethanol or purified water;
Preparing a secondary particle by heating a group consisting of a primary alcohol, a secondary alcohol, a fatty acid, a polysaccharide, a gum, and titanium oxide or zinc oxide singly or in combination thereof to form secondary particles using ethanol or purified water as a dispersion medium; ≪ / RTI >
And coating the secondary particles with a hydrophilic polymer or a lipophilic polymer.
Wherein the hydrophilic polymer is carbomer, hydroxyethyl cellulose or carrageenan gum, and the oleophilic polymer is shellac or a silicone powder.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150137654A KR101736147B1 (en) | 2015-09-30 | 2015-09-30 | Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020150137654A KR101736147B1 (en) | 2015-09-30 | 2015-09-30 | Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
KR20170038991A KR20170038991A (en) | 2017-04-10 |
KR101736147B1 true KR101736147B1 (en) | 2017-05-17 |
Family
ID=58581207
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020150137654A KR101736147B1 (en) | 2015-09-30 | 2015-09-30 | Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof |
Country Status (1)
Country | Link |
---|---|
KR (1) | KR101736147B1 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111592944B (en) * | 2020-05-21 | 2021-07-27 | 上海毅诺生物科技有限公司 | Multi-surface cleaning agent containing tea saponin modified surfactant |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101052322B1 (en) | 2009-06-17 | 2011-07-27 | 김진훈 | Method of preparing athlete's foot treatment composition |
-
2015
- 2015-09-30 KR KR1020150137654A patent/KR101736147B1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
KR20170038991A (en) | 2017-04-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR101736149B1 (en) | Dry multiple encapsulated composition containing photosensitizer for improvement of a pimpled skin and preparation thereof | |
Li et al. | Singlet oxygen-responsive micelles for enhanced photodynamic therapy | |
Zhang et al. | Transferrin-mediated fullerenes nanoparticles as Fe2+-dependent drug vehicles for synergistic anti-tumor efficacy | |
CN102159250B (en) | Multi-arm polymeric alkanoate conjugates | |
KR101336501B1 (en) | Nano ion-complex for photodynamic theraphy comprising hydrophile cationic polymer photosensitizer derivatives and anionic polysaccharide quencher derivatives | |
Li et al. | Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment | |
JPWO2004039869A1 (en) | Polymer derivatives of camptothecins | |
WO2005099689A1 (en) | Topical delivery of phthalocyanines | |
CN112076159B (en) | Drug-loaded polymer vesicle with asymmetric membrane structure, preparation method and application thereof in preparation of drugs for treating acute myelogenous leukemia | |
CN111617246B (en) | Self-assembled nanoparticles of pure photosensitizer and preparation and application thereof | |
Li et al. | Photodynamic therapy-mediated remote control of chemotherapy toward synergistic anticancer treatment | |
EP2830591B1 (en) | Material, its process of preparation and utilisations thereof | |
KR101736147B1 (en) | Dry multiple encapsulated composition containing photosensitizer for improvement of athlete's foot and preparation thereof | |
KR20080002814A (en) | Polymeric pharmaceutical agent for treatment of cancer and process for production of the same | |
CN1777610B (en) | Water-soluble mono-pegylated tetrapyrrole derivatives for photodynamic therapy and method of production | |
KR101622544B1 (en) | Athlete's foot treatment composition and method for manufacturing athlete's foot treatment preparation using the same | |
KR101622545B1 (en) | Acne treatment composition and method for manufacturing acne treatment preparation using the same | |
CN104817688A (en) | Convertible surface charge nano-gel, preparation method thereof and convertible surface charge nano-gel drug-loaded particle | |
KR102104943B1 (en) | Polymeric conjugates for polysaccharide-based photodynamic therapy and uses thereof | |
US20190192529A1 (en) | Methods and pharmaceutical compositions for treating candida auris in blood | |
CN111393465A (en) | Axial galactose/lactose modified silicon phthalocyanine and preparation method and application thereof | |
CN114377141B (en) | Drug delivery carrier and anti-tumor application thereof | |
Yang et al. | Construction of Actively Targeted and High Drug Content Polyprodrug Amphiphiles to Perform Synergistic Chemo–Photo-Anti-Tumor Therapy and Immune-Activated Investigation | |
CN114903872B (en) | Dendrimer self-assembly body for co-delivering tripterine and Bcl-2-functional conversion peptide, and preparation method and application thereof | |
CN113041359B (en) | Glutathione-responsive osteosarcoma-resistant prodrug nanoparticle and preparation method and application thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E701 | Decision to grant or registration of patent right | ||
GRNT | Written decision to grant |