KR20160026824A - 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물 - Google Patents

카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물 Download PDF

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KR20160026824A
KR20160026824A KR1020157022953A KR20157022953A KR20160026824A KR 20160026824 A KR20160026824 A KR 20160026824A KR 1020157022953 A KR1020157022953 A KR 1020157022953A KR 20157022953 A KR20157022953 A KR 20157022953A KR 20160026824 A KR20160026824 A KR 20160026824A
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cancer
targeted
chemotherapeutic
resistance
patient
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Korean (ko)
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라시다 에이. 카말리
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탁티칼 떼라페우틱스 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020157022953A 2013-04-01 2014-03-28 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물 Abandoned KR20160026824A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/986,103 US9089570B2 (en) 2010-09-03 2013-04-01 Compositions for treating cancers having acquired resitance to prior chemotherapeutic and targeted drugs using carboxyamidotriazole orotate
US13/986,103 2013-04-01
PCT/US2014/032253 WO2014165412A2 (en) 2013-04-01 2014-03-28 Methods and compositions for treating cancers having acquired resistance to chemotherapeutic and targeted drugs using carboxyamidotriazole orotate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217003925A Division KR20210019116A (ko) 2013-04-01 2014-03-28 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물

Publications (1)

Publication Number Publication Date
KR20160026824A true KR20160026824A (ko) 2016-03-09

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Application Number Title Priority Date Filing Date
KR1020157022953A Abandoned KR20160026824A (ko) 2013-04-01 2014-03-28 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물
KR1020217003925A Withdrawn KR20210019116A (ko) 2013-04-01 2014-03-28 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물

Family Applications After (1)

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KR1020217003925A Withdrawn KR20210019116A (ko) 2013-04-01 2014-03-28 카복시아미도트리아졸 오로테이트를 사용하여 화학치료제 및 표적화된 약물에 대해 내성을 획득한 암을 치료하기 위한 방법 및 조성물

Country Status (10)

Country Link
US (1) US9089570B2 (cg-RX-API-DMAC7.html)
EP (1) EP2981169B1 (cg-RX-API-DMAC7.html)
JP (1) JP6410795B2 (cg-RX-API-DMAC7.html)
KR (2) KR20160026824A (cg-RX-API-DMAC7.html)
CN (1) CN105120663B (cg-RX-API-DMAC7.html)
AU (1) AU2014248377B2 (cg-RX-API-DMAC7.html)
CA (1) CA2902144C (cg-RX-API-DMAC7.html)
IL (1) IL241827B (cg-RX-API-DMAC7.html)
WO (1) WO2014165412A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201506037B (cg-RX-API-DMAC7.html)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016015095A1 (en) * 2014-07-31 2016-02-04 The University Of Western Australia A method for the identification of immunotherapy-drug combinations using a network approach
RS62108B1 (sr) 2016-03-02 2021-08-31 Eisai R&D Man Co Ltd Antitelo-lek konjugati na bazi eribulina i postupci primene
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
CN107890467A (zh) * 2017-11-24 2018-04-10 中国医学科学院基础医学研究所 干扰能量代谢的药物在胰腺癌复发中的应用
US20220168276A1 (en) 2020-08-05 2022-06-02 Tactical Therapeotics Inc. Mehods and Compositions for Treating SARS-CoV-2 Infection using Carboxyamidotriazole Orotate
CN118766907A (zh) * 2023-04-04 2024-10-15 广东银珠医药科技有限公司 羧胺三唑在制备治疗肿瘤骨转移的药物中的用途
WO2024235217A1 (zh) * 2023-05-15 2024-11-21 广东银珠医药科技有限公司 一种抗肺癌联合用药物及其应用
CN119971050A (zh) * 2023-11-10 2025-05-13 广东银珠医药科技有限公司 羧胺三唑与化疗药的组合物及联用治疗实体瘤的用途
CN120817906A (zh) * 2024-04-12 2025-10-21 广东银珠医药科技有限公司 一种三氮唑类化合物及其用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997003668A1 (en) * 1995-07-21 1997-02-06 Constantia Gruppe Treatment and prevention of neoplasms with salts of aminoimidazole carboxamide and 5-amino or substituted amino 1,2,3-triazoles
US5728707A (en) 1995-07-21 1998-03-17 Constantia Gruppe Treatment and prevention of primary and metastatic neoplasms with salts of aminoimidazole carboxamide
US8034823B2 (en) * 2005-02-22 2011-10-11 Savvipharm Inc Method of increasing drug oral bioavailability and compositions of less toxic orotate salts
US7750018B2 (en) * 2006-12-06 2010-07-06 Tactical Therapeutics, Inc Use of carboxiamidotriazole (CAI) orotate in macular degeneration
BRPI0815116A2 (pt) * 2007-08-13 2015-01-27 Synta Pharmaceuticals Corp Compostos de triazol que modulam a atividade da hsp90
CN101669941B (zh) * 2008-09-09 2012-11-07 中国医学科学院基础医学研究所 一种联合用药治疗恶性肿瘤的方法以及抗恶性肿瘤的药物
EP2963023B1 (en) * 2009-09-04 2018-04-18 Tactical Therapeutics, Inc. Process for preparing 5-amino-1, 2, 3-triazole orotate derivatives
US8877785B2 (en) * 2009-09-04 2014-11-04 Tactical Therapeutics Inc Methods and compositions for enhancing sensitivity of cytotoxic drugs with timely combinatorial therapy with carboxyamidotriazole orotate

Also Published As

Publication number Publication date
AU2014248377B2 (en) 2018-02-01
CA2902144A1 (en) 2014-10-09
JP2016515619A (ja) 2016-05-30
EP2981169A2 (en) 2016-02-10
EP2981169B1 (en) 2021-05-05
AU2014248377A1 (en) 2015-09-03
EP2981169A4 (en) 2016-09-14
KR20210019116A (ko) 2021-02-19
US9089570B2 (en) 2015-07-28
CN105120663B (zh) 2017-08-04
IL241827B (en) 2019-02-28
ZA201506037B (en) 2021-09-29
JP6410795B2 (ja) 2018-10-24
US20140294806A1 (en) 2014-10-02
HK1214921A1 (zh) 2016-08-12
WO2014165412A2 (en) 2014-10-09
CN105120663A (zh) 2015-12-02
CA2902144C (en) 2021-02-09
WO2014165412A3 (en) 2015-01-29

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