KR20150132473A - 항-혈장 칼리크레인 항체 - Google Patents

항-혈장 칼리크레인 항체 Download PDF

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Publication number
KR20150132473A
KR20150132473A KR1020157029559A KR20157029559A KR20150132473A KR 20150132473 A KR20150132473 A KR 20150132473A KR 1020157029559 A KR1020157029559 A KR 1020157029559A KR 20157029559 A KR20157029559 A KR 20157029559A KR 20150132473 A KR20150132473 A KR 20150132473A
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KR
South Korea
Prior art keywords
antibody
gly
ser
pkal
thr
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Ceased
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KR1020157029559A
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English (en)
Korean (ko)
Inventor
앤드류 닉슨
존 에이. 케니스톤
스티븐 알. 코모
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다이액스 코포레이션
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Publication of KR20150132473A publication Critical patent/KR20150132473A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
    • C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
    • C12N9/6408—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Microbiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
KR1020157029559A 2013-03-15 2014-03-14 항-혈장 칼리크레인 항체 Ceased KR20150132473A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791822P 2013-03-15 2013-03-15
US61/791,822 2013-03-15
PCT/US2014/027100 WO2014152232A2 (en) 2013-03-15 2014-03-14 Anti-plasma kallikrein antibodies

Publications (1)

Publication Number Publication Date
KR20150132473A true KR20150132473A (ko) 2015-11-25

Family

ID=51581689

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157029559A Ceased KR20150132473A (ko) 2013-03-15 2014-03-14 항-혈장 칼리크레인 항체

Country Status (10)

Country Link
US (4) US20160017055A1 (cg-RX-API-DMAC7.html)
EP (2) EP3594244A1 (cg-RX-API-DMAC7.html)
JP (2) JP2016513682A (cg-RX-API-DMAC7.html)
KR (1) KR20150132473A (cg-RX-API-DMAC7.html)
CN (3) CN111704672B (cg-RX-API-DMAC7.html)
AU (4) AU2014240045A1 (cg-RX-API-DMAC7.html)
CA (2) CA2906624A1 (cg-RX-API-DMAC7.html)
HK (1) HK1218762A1 (cg-RX-API-DMAC7.html)
IL (2) IL292121B2 (cg-RX-API-DMAC7.html)
WO (1) WO2014152232A2 (cg-RX-API-DMAC7.html)

Families Citing this family (15)

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SI3459564T1 (sl) 2010-01-06 2022-06-30 Takeda Pharmaceutical Company Limited Proteini, ki vežejo plazemski kalikrein
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CN111704672B (zh) 2013-03-15 2024-06-04 武田药品工业株式会社 抗血浆激肽释放酶抗体
EA038532B1 (ru) 2014-01-21 2021-09-10 Такеда Фармасьютикал Компани Лимитед Способ лечения наследственного ангионевротического отека (hae)
IL295414B1 (en) 2014-03-27 2025-10-01 Takeda Pharmaceuticals Co Compositions and methods for treating macular edema due to diabetes
IL298086B2 (en) * 2015-01-02 2024-11-01 Takeda Pharmaceuticals Co Bispecific antibodies against plasma kallikrein and factor xii
EP3286226A4 (en) * 2015-03-30 2018-12-05 Dyax Corp. Plasma kallikrein inhibitors and uses thereof for preventing hereditary angioedema attack
EP3325516B1 (en) 2015-07-21 2021-12-15 Takeda Pharmaceutical Company Limited A monoclonal antibody inhibitor of factor xiia
US11286307B2 (en) * 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
BR112020007405A2 (pt) * 2017-10-18 2020-12-08 Regenxbio Inc. Produtos terapêuticos de anticorpo pós-translacionalmente modificados totalmente humanos
MX2021002349A (es) * 2018-08-30 2021-05-31 Takeda Pharmaceuticals Co Inhibidores de calicreína en plasmá y usos de los mismos para tratar ataque de angioedema hereditario.
EP3983449A1 (en) 2019-06-11 2022-04-20 Shire Human Genetic Therapies, Inc. Adeno associated viral vector delivery of antibodies for the treatment of disease mediated dysregulated plasma kallikrein
CN116829595A (zh) 2020-12-16 2023-09-29 武田药品工业株式会社 用于治疗由失调的血浆激肽释放酶介导的疾病的抗体的腺相关病毒载体递送
CN114790246A (zh) * 2021-01-25 2022-07-26 成都康弘生物科技有限公司 一种抗体及其用途
CN114790245A (zh) * 2021-01-25 2022-07-26 成都康弘生物科技有限公司 一种抗体及其用途

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US11286307B2 (en) 2015-12-11 2022-03-29 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack
MX2021002349A (es) 2018-08-30 2021-05-31 Takeda Pharmaceuticals Co Inhibidores de calicreína en plasmá y usos de los mismos para tratar ataque de angioedema hereditario.
EP3938404A1 (en) 2019-03-14 2022-01-19 Takeda Pharmaceutical Company Limited Plasma kallikrein inhibitors and uses thereof for treating hereditary angioedema attack

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AU2021200144B2 (en) 2024-06-20
CA3208188A1 (en) 2014-09-25
AU2024219756A1 (en) 2024-10-10
WO2014152232A2 (en) 2014-09-25
CA2906624A1 (en) 2014-09-25
AU2019200638B2 (en) 2021-01-28
US20190185580A1 (en) 2019-06-20
JP2020007354A (ja) 2020-01-16
EP3594244A1 (en) 2020-01-15
CN111704672A (zh) 2020-09-25
IL292121B1 (en) 2023-10-01
IL241334A0 (en) 2015-11-30
AU2021200144A1 (en) 2021-03-18
AU2019200638A1 (en) 2019-02-21
US12110343B2 (en) 2024-10-08
EP2970502A4 (en) 2016-11-30
CN118406688A (zh) 2024-07-30
US20160017055A1 (en) 2016-01-21
EP2970502A2 (en) 2016-01-20
BR112015022282A2 (pt) 2017-10-10
US20230002509A1 (en) 2023-01-05
JP2016513682A (ja) 2016-05-16
HK1218762A1 (zh) 2017-03-10
US11299553B2 (en) 2022-04-12
IL292121B2 (en) 2024-02-01
CN105051068A (zh) 2015-11-11
WO2014152232A3 (en) 2014-11-13
US20250129182A1 (en) 2025-04-24
IL241334B (en) 2022-05-01
AU2014240045A1 (en) 2015-09-10
IL292121A (en) 2022-06-01
CN111704672B (zh) 2024-06-04

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