KR20150127179A - Multiple compartment syringe - Google Patents

Abstract

A variety of syringe systems are disclosed. One exemplary syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to receive a plurality of fluids therein. The first plunger may be positioned within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and form a first compartment between the distal end of the first plunger and the syringe. The second plunger is proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with the inner wall of the syringe body and forms a second compartment between the first plunger and the second plunger . A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body.

Description

{MULTIPLE COMPARTMENT SYRINGE}

[Related Application]

This application claims benefit of U.S. Serial No. 13 / 802,372, filed on March 13, 2013, entitled " Multiple Compartment Syringe ", the entire contents of which are incorporated herein by reference.

During radiotherapy, contrast agents may be administered to improve the imaging of the anatomical features within the patient. A physician can usually order a specific amount of contrast agent that is considered necessary to observe these anatomical features. Contrast agents can be expensive, so it can be important to ensure that a complete dosage is administered and that there is little or no waste. In addition, the contrast agent may need to be pushed to the area of interest, or it may need to be diluted to avoid having too much contrast agent in the area of interest.

Previous attempts to ensure dilution associated with injecting a complete contrast medium, pushing into the area of interest, and / or injecting a cleansing material such as saline may be accomplished by flushing the contrast medium into the area of interest Or to dilute contrast media. In some radiological surgeries, this can be accomplished by automated devices. However, passive devices may be used for a variety of reasons, such as in some radiological surgeries, for example, an automated device is not available or does not require a level of delivery control that may be possible with an automated surgical device. Passive devices currently used in the art, however, lack the ability to control delivery in a manner similar to automated devices, thereby resulting in waste of contrast media, improper delivery of contrast media, and / or improper dilution of contrast media.

In addition, when the contrast agent is not actively delivered, it may be necessary to ensure that the patient's access vein remains open. In some patients with disease in the vasculature, the veins may collapse when contrast media is not actively supplied. Under these conditions, the amount of a portion of the fluid such as saline can be delivered intravenously, for " keep vein open (KVO). "

In one embodiment, the syringe may include a syringe body having a hollow lumen and a distal end, and the syringe body may be configured to receive a plurality of fluids therein. The first plunger may be positioned within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and form a first compartment between the distal end of the first plunger and the syringe. The second plunger is proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with the inner wall of the syringe body and forms a second compartment between the first plunger and the second plunger . A plurality of recesses may be disposed about the inner wall of the syringe body near the distal end of the syringe body. In certain embodiments, the fluid bypass may be disposed about the inner wall of the syringe body and around the first plunger at or near the distal end of the syringe body, wherein the first fluid flows through the fluid bypass to the second compartment can do. The syringe may further include a mechanism for proximal movement of the first plunger proximally relative to the fluid bypass so that the first plunger forms a first seal. The device includes a slidable end cap at a distal end of the syringe body, a push rod configured to push the first plunger in a proximal direction, at least one magnet at or near the distal end of the sleeve, Such as one of a magnet or a sleeve that is magnetically coupled to the ferromagnetic body.

In one embodiment, the syringe system may include a syringe body having a hollow lumen and a distal end including a syringe tip, and the syringe body may be configured to receive a plurality of fluids therein. Additionally, the first plunger may be located within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and form a first compartment between the distal end of the first plunger and the syringe. The second plunger is proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with the inner wall of the syringe body and forms a second compartment between the first plunger and the second plunger . A transfer tube may be in fluid communication with the second compartment and the syringe tip.

In one embodiment, the syringe system may include a syringe body having a distal end with a hollow lumen and a syringe tip. The syringe body may be configured to receive a plurality of fluids therein. The syringe system may also include a first plunger positioned within the hollow lumen of the syringe body. The first plunger may form a first seal with the inner wall of the syringe body and may form a first compartment between the distal end of the first plunger and the syringe. The second plunger is proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with the inner wall of the syringe body and forms a second compartment between the first plunger and the second plunger . The syringe system may also include a delivery tube in fluid communication with the second compartment. The delivery tube may include a valve having an outlet, and the valve is in fluid communication with the syringe tip. The syringe system may also include an outlet port fluidly connected to the outlet of the valve. The orientation of the valve may include a first open state in which fluid flows from the syringe tip to the outlet port, a second open state in which fluid flows from the delivery tube to the outlet port, fluid flows from both the syringe tip and the delivery tube to the outlet port, , And a closed state to block flow of fluid from the syringe tip and the delivery tube.

In one embodiment, the syringe system may include a syringe body having a hollow lumen and a distal end. The syringe body may be configured to receive a plurality of fluids therein. The syringe system is also a first plunger positioned within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and a first compartment between the distal end of the first plunger and the syringe, And a first plunger including a lumen. A second plunger may be positioned within the hollow lumen of the first plunger to form a second seal with the inner wall of the first plunger and form a second compartment between the first plunger and the second plunger.

In one embodiment, the syringe system may include a syringe body having a first chamber, a second chamber, and an outlet in fluid communication with the first chamber and the second chamber. The first chamber may be positioned adjacent to the second chamber. The first chamber may have a smaller diameter than the diameter of the second chamber. The first chamber may be configured to receive a first fluid and the second chamber may be configured to receive a second fluid. The syringe system may also include a first plunger located within the first chamber and a second plunger located within the second chamber. The syringe system may also include an adjustable stop configured to stop the distal movement of the first plunger after the first plunger traverses the defined distance. The second plunger may be configured to move in a distal direction to push the second fluid out of the second chamber into the outlet. The first fluid may be drawn from the first plunger through the venturi effect resulting from the distal movement of the second plunger.

In the following detailed description, reference is made to the accompanying drawings which form a part hereof. In the drawings, like reference numerals usually denote similar parts, unless the context clearly indicates otherwise. The illustrative embodiments, figures, and claims set forth in the Detailed Description are not to be considered limiting. Other embodiments may be utilized and other changes may be made without departing from the spirit or scope of the disclosure herein. Aspects of the present invention as generally described herein and illustrated in the drawings may be arranged, substituted, combined, separated, and designed in a wide variety of different configurations, all of which are readily understood by those skilled in the art Will be.
1A and 1B show side views of a syringe according to an embodiment.
Figure 2a shows a side view of an alternative syringe with a delivery tube according to an embodiment.
Fig. 2b shows a side view of an alternative syringe of Fig. 2a having an alternative positioned delivery tube according to an embodiment.
Figure 3 illustrates various alternative orientations of valves used in the syringe of Figures 2a and 2b according to an embodiment.
Figure 4 shows a side view of another alternative syringe according to an embodiment.
Figure 5 shows a side view of yet another alternative syringe according to an embodiment.
6A-6D illustrate the movement of various components of the syringe shown in Figs. 1A and 1B according to an embodiment.
Figures 7A-7C illustrate movement of various components of the syringe shown in Figure 2A according to an embodiment.
Figures 8a-8c illustrate the movement of various components of the syringe shown in Figure 5 according to an embodiment.
Figures 9A-9C illustrate the movement of various components of a syringe according to an embodiment.
FIGS. 10A and 10B show the suction process of the syringe according to the embodiment.
11A and 11B show the suction process of the syringe according to the embodiment.

The particular system, apparatus, and method described may vary and the invention is not limited to the particular systems, apparatus, and methods described. It is to be understood that the terminology used herein is for the purpose of description only of a specific form or embodiment and is not intended to limit the scope of the invention.

As used herein, the singular forms "a "," an ", and "the" include plural forms unless the context clearly dictates otherwise. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. The present invention is not to be construed as an admission that the embodiment described in the present invention is not entitled to precede such disclosure by the conventional invention. As used herein, the term " comprising "means" including but not limited to. &Quot;

The terms "upper", "lower", "right", "left", "vertical", "horizontal", "upper", "lower", " And derivatives thereof may be associated with the orientation of the embodiments disclosed in the figures. However, in contrast, the embodiment may assume alternative variations and step sequences, unless explicitly specified otherwise. The specific arrangements and processes illustrated in the accompanying drawings and described in the following description are exemplary embodiments. Therefore, the physical features associated with the embodiments disclosed herein are not considered to be limiting.

The term "proximal" refers to a direction relative to a clinician or operator using the apparatus described herein, and the term "distal" refers to a direction that is relatively farther away from the clinician or operator . For example, the tip of the syringe positioned closest to the patient ' s body is considered the distal end of the syringe, while the end closest to the clinician is the proximal end of the syringe. The term "axial" or "axially" refers to an axis in which a particular object is generally referred to, preferably formed around it (though not necessarily symmetrical about it). The term "radial" generally refers to a direction perpendicular to the axis or a direction along a radius of an object having a circular cross-section.

Various embodiments of the present invention may be directed to an apparatus and method of using a passive device for delivering a bolus of contrast agent followed by the delivery of any amount of saline solution. In various embodiments, the device may be responsible for ensuring that all of the contrast agent is delivered to the patient to move the contrast agent to the area of interest, or to clean the line to dilute the contrast agent concentration. In various embodiments, the device and method of use may also deliver a small amount of fluid to maintain vein patency during contrast media administration.

1A shows a side view of a syringe designated generally as 100 according to an embodiment. The syringe 100 generally includes a syringe body 105 having a distal end 102 having a hollow lumen 107, a proximal end 101 and a distal end 110. The shape or size of the syringe body 105 is not limited by the present invention and may be any shape or size and may be, in particular, the shape and size of a syringe body commonly known by those skilled in the art. In various embodiments, the syringe body 105 may be substantially cylindrical. In various embodiments in which the syringe 100 is configured for use in a computed tomography (CT) application, etc., the syringe body 105 may be configured to receive about 20 ml to about 150 ml of fluid therein. In a particular embodiment, the syringe body is provided with a fluid in the range of about 20 ml, about 25 ml, about 30 ml, about 50 ml, about 75 ml, about 100 ml, about 125 ml, about 150 ml, or any value or any two of these values Lt; / RTI > In various embodiments in which the syringe 100 is configured for use in a magnetic resonance (MR) application, etc., the syringe body 105 may be configured to receive about 5 ml to about 20 ml of fluid therein. In certain embodiments, the syringe body may be configured to receive a fluid in a range of about 5 ml, about 10 ml, about 12.5 ml, about 15 ml, about 20 ml, or any value or any two of these values.

In various embodiments, the hollow lumen 107 may include a plurality of plungers disposed therein. For example, in this embodiment, the hollow lumen 107 may have a first plunger 120 and a second plunger 135. However, those skilled in the art will recognize that more than two plungers can be used without departing from the scope of the present invention. In various embodiments, the first plunger 120 may form a seal with respect to the interior of the syringe body 105 by the first seal 125. In some embodiments, the first seal 125 may be a separate component from the first plunger 120, such as, for example, an added O-ring or the like. In this embodiment, the first seal 125 may be fixedly attached to the first plunger 120 by any attachment means, including attachment devices, and / or adhesives, etc., or the first seal may be fixedly attached to the first plunger 120, As shown in FIG. In another embodiment, the first seal 125 may be fabricated as part of the first plunger 120. Likewise, in various embodiments, the second plunger 135 may form a seal for the interior of the syringe body 105 by the second seal 140. In some embodiments, the second seal 140 may be a separate component from the second plunger 135, such as, for example, an added O-ring or the like. In this embodiment, the second seal 140 may be fixedly attached to the second plunger 135 by any attachment means, including attachment devices, and / or adhesives, etc., or the second seal may be fixedly attached to the second plunger 135, As shown in FIG. In another embodiment, the second seal 140 may be fabricated as part of the second plunger 135. The first plunger 120, the second plunger 135, the first seal 125, and the second seal 140 are each known or later developed by a person skilled in the art for use as a plunger and / And may be made of any material. Specific examples may include polymers and / or rubbers and the like.

In various embodiments, a first compartment 160 may be formed between the distal end 102 of the first plunger 120 and the syringe body 105. The first compartment 160 may be configured to receive fluid therein. In certain embodiments, the fluid may comprise a contrast agent. In various embodiments, a second compartment 165 may be formed between the second plunger 135 and the first plunger 120. The second compartment 165 may also be configured to receive fluid therein. In certain embodiments, the fluid may comprise a flushing fluid. One specific example of a cleaning fluid may be saline. The volume of the first compartment 160 may be determined by the distance between the first plunger 120 and the distal end 102 of the syringe body 105 and the circumference of the syringe body. The volume of the second compartment 165 may be determined by the distance between the first plunger 120 and the second plunger 135 and the circumference of the syringe body 105.

In various embodiments, the first plunger 120 and the second plunger 135 may be joined together by a connecting piece 130. [ The connecting piece 130 may be configured such that when a force is applied to the second plunger 135, a portion of the force is transmitted to the first plunger 120 to move the first plunger with the second plunger. In some embodiments, the movement may be bi-directional, i.e. the force may be directed proximal or circular to move the first plunger 120 and the second plunger 135 proximal or distal in the syringe. In this embodiment, the connecting piece 130 may be made of a rigid material that does not bend or fold when pressure is applied to the connecting piece. The connecting piece 130 may also be made of any material that does not affect any fluid that may contact the connecting piece. In other embodiments, the movement may be unidirectional, i.e., a force that pushes the second plunger 135 in the distal direction so that the first plunger is in position may not be transmitted to the first plunger 120, When a force in the proximal direction is applied to the second plunger, a force is transmitted to the first plunger to also move the first plunger. In some embodiments, this unidirectional movement, as shown in FIG. 1A, may be enabled by using a connecting piece 130 'of a collapsible material. Specific examples of materials that can be folded include filaments, monofilaments, fibers, polymers, and the like. In some embodiments, the connecting piece 130 or 130 'is configured such that the force applied to the second plunger 135 causes a force applied to the first plunger 120 by magnetic attraction, . ≪ / RTI > In some embodiments, the connecting piece 130 or 130 ' may comprise a releasable pin or similar locking device that can lock or unlock the connecting piece to cause a desired movement of the plunger 120,135 as described herein . ≪ / RTI > As in other arrangements, the connecting piece 130 or 130 'may also be made of any material that does not affect any fluid that may contact the connecting piece.

In embodiments in which the connecting piece is a collapsible material 130 ', the first plunger 120 is moved in the direction of the circle of the syringe body 105 by a force from the fluid located in the second chamber 165, Can be moved toward the upper end 102. For example, due to the action of the second seal 140 and the first seal 125, the fluid contained in the second compartment 165 is not leaked or compressed, but acts as a hydraulic lock, To the first plunger (120). In this manner, fluid located within the first compartment 160 may be pushed over the circle by the first plunger 120 and, in some embodiments, may be ejected outside the syringe tip 110.

The second plunger 135 may be connected to a piston 145 which may at least partially extend from an opening in the proximal end 101 of the syringe body 105. In other embodiments, The second plunger 135 may be attached to the piston 145 by any attachment means, including, but not limited to, any number of clips, fasteners, hooks and / In some embodiments, the second plunger 135 may be molded as part of the piston 145. In some embodiments, the piston 145 may have a thumb piece 150 attached proximal to the piston 145. The island piece 150 generally has a stable surface such that the user of the syringe 100 pushes / pushes / pulls the piston 145 and, correspondingly, the second plunger 135 and / or the first plunger 120 . Although the island piece 150 shown herein is a generally flat surface, those skilled in the art will appreciate that the shape and size of the island piece is not limited by the present invention, and any number of rings, openings and / or shapes may be used without departing from the scope of the present invention. And may include contoured surfaces. Those skilled in the art will also appreciate that the term " island piece " is not limited, and that a user may use any object to manipulate the island piece 150 as described herein.

In various embodiments, the inner surface of the syringe body 105 can include a plurality of recesses 155 disposed therein, creating voids in portions of the inner surface at the locations of each recess. In some embodiments, a plurality of grooves 155 may be disposed about the inner wall of the syringe body 105 near the distal end 102. The shape and size of the groove 155 is not limited to the present invention and may be any shape and / or size that can break the seal between the syringe body 105 and the first seal 125 of the first plunger 120, Or size. In some embodiments, the groove 155 may be scalloped. In another embodiment, the groove 155 may be crenelated. The groove 155 may be located at any location on the inner wall of the syringe body 105 and may be positioned to correspond to the amount of fluid required in the first compartment 160 and / or the second compartment 165. However, since the fluid in the second compartment 165 is not discharged, the recess 155 can not be located to the distal end of the syringe body where the first seal 125 is not in contact. In some embodiments, the groove 155 may be located at a tapered transition point from the cylindrical syringe body 105 to the tip 110.

In various embodiments, one or more finger guard (s) 115 may be positioned at a location generally located at or near the proximal end 101 of the syringe body 105. In some embodiments, the finger guard 115 may be positioned generally on the outer surface of the syringe body 105 and extend generally from the outer surface of the syringe body. In some embodiments, the finger guard 115 may act to provide stability to the syringe 100 during operation. In some embodiments, the user may use the finger guard 115 to prevent movement of the syringe 100 during operation. In some embodiments, the user may use the finger guard 115 to prevent the syringe 100 from slipping out of the user's hand. In some embodiments, the user may use the finger guard 115 to protect the user's fingers. In some embodiments, the finger guard 115 may act as a stop device to prevent the piston 145 from moving further over the circle within the syringe body 105. [ The shape and size of the finger guard 115 is not limited by the present invention and may be any shape and / or size known in the art. A specific example of the shape may be a ring shape, a wedge shape, a T-shape, a curved shape, and / or a curved shape with finger indentation.

Figure 2a shows a side view of an alternative syringe, generally designated 200, according to an embodiment. The syringe 200 may include a syringe body 205 having a proximal end 201 and a distal end 202, similar to the syringe 100 described with reference to Figures 1A and 1B described above. The syringe body 205 may have a first plunger 220 and a second plunger 235 disposed therein. The first plunger 220, the second plunger 235 and the tip 210 have a first compartment 260 and a second compartment 260 for storing two different types of fluids therein, 265 can be partitioned. The first plunger 220 and the second plunger 235 can be moved within the syringe body 205 by applying a force to a portion of the island piece 250 of the piston 245 as described herein. In some embodiments, movement of the first plunger 220, as described herein, may be supported by the connecting piece 230. Movement of the first plunger 220 is such that the force exerted on the second plunger 235 is transmitted through the fluid located in the second compartment 265 to the first plunger 235 through the fluid located in the second compartment 265. In an alternative embodiment, 220, < / RTI >

2A may be different from the syringe of Figs. 1A and 1B by including, among other things, a delivery tube 270, a valve 275, and one or more outlet ports 280. In other embodiments, . In some embodiments, groove 255 may not be present. In some embodiments, the functionality of this additional element, as described herein, may cause the injector 200 to provide a " keep vein open (KVO) "function. The KVO function may be used during a long-term scanning procedure to ensure that access to the vein is not retained and collapsed in the fluid scan when the fluid is not being administered. In some embodiments, the function of this additional element is to allow the syringe 200 to deliver fluid in the second compartment 265 before delivering the fluid in the first compartment 260, and vice versa, . ≪ / RTI > In some embodiments, the function of this additional element is that the syringe 200 is configured to mix at least a portion of the contents in the first compartment 260 during delivery to the patient with at least a portion of the contents in the second compartment 265 Functionality can be provided. In some embodiments, the function of this additional element may be to cause the syringe 200 to be in an "off" state, thereby preventing any leaks when the syringe is not in use, 260, and 265 to prevent the contents from escaping.

In various embodiments, the delivery tube 270 may be in fluid communication with the contents of the second compartment 265 in the syringe body 205. Thus, in some embodiments, the syringe body 205 may include openings and / or bores therein for attachment of the transfer tube 270 to allow its fluid connection. The configuration of the transfer tube 270 is not limited to the present invention, but may be any shape, size, and / or configuration. In some embodiments, the transfer tube 270 may be generally hollow for delivery of fluid therethrough, and may be made of a material that does not affect the fluid flowing therethrough as a whole.

In an alternate embodiment, such as the embodiment shown in FIG. 2B, the transfer tube 270'is positioned between the contents of both the first compartment 260 and the second compartment 265, in accordance with the positioning of the plungers 220, 235, Fluid connection. In some embodiments, the transfer tube 270 'may serve as an alternative to the recess 255 (FIG. 2A). Therefore, only when the first compartment 260 is exposed to the transfer tube and particularly when the valve 275 is positioned, the transfer tube 270 'is moved to the first compartment 260, as described in more detail herein / RTI > may allow for the transfer of fluid from the < / RTI > In addition, as described herein, only when the second compartment 265 is exposed to the transfer tube and particularly when the valve 275 is positioned, the transfer tube 270 'is moved to / from the second compartment 265 It may allow the transfer of fluid. Also, since there is no recess in this embodiment, it is possible to form a seal with the inner wall of the syringe body 205, even if the first plunger 220 is forcibly moved in the distal direction, Only the fluid in the second compartment 265 may exit the syringe 200 through the delivery tube 270 ', especially when the valve 275 is positioned.

As shown in either embodiment of Figs. 2A and 2B, the delivery tube 270 may be terminated within the valve 275. In some embodiments, the valve 275 may be in fluid communication with the transfer tube 270, the tip 210 and the outlet port 280. In various embodiments, the valve 275 may be configured to be positioned in one of a plurality of states, such as shown in Figure 3, in which the valve is open to any element of the fluidly coupled element or not open to any element . the first state causes the contents to flow from both the tip 210 and the delivery tube 270 to the outlet port 280, as shown in position (a). As shown in position (b), the second state allows only the contents to be dispensed from the delivery tube 270 into the outlet port 280, as it blocks the contents within the tip 210. As shown in position (c), the third state allows only the contents to be dispensed from the tip 210 into the outlet port 280 as it blocks the contents in the transfer tube 270. As shown in position (d), the fourth state allows the contents of either position to be dispensed into the outlet port 280, since the valve 275 is closed by both the delivery tube 270 and the tip 210. [ . Those skilled in the art will recognize that the contents may be introduced into the syringe 200 in a similar manner, as described in more detail herein.

In various embodiments, the outlet port 280 may be connected to the first chamber 260, the second chamber 265, the chamber 270, or both, depending on the orientation of the valve 275 and / Or may be configured not to accept content from any chamber. The outflow port 280 may also be configured to output any contents received by the patient. In some embodiments, the outlet port 280 can be configured to be rigidly attached to additional elements such as tubes, needles, nozzles, valves and catheters, etc. to assist delivery of the contents to the patient.

Figure 4 shows a side view of another alternative syringe system according to an embodiment. The syringe system 400 may include a syringe body 405 having a first chamber 410 and a second chamber 420. Unlike the other embodiments shown herein, the first chamber 410 and the second chamber 420 may not coincide with each other. Rather, the chambers 410, 420 may be positioned adjacent to each other, for example, substantially parallel to each other. The distal end of each chamber 410, 420 may be fluidly connected to an output 445. In some embodiments, the output 445 may be configured to convey the contents of the first chamber 410 and / or the second chamber 420 to a target. In some embodiments, the output 445 may be configured to attach to other devices, such as, for example, tubes, nozzles, needles, valves and catheters, etc., as described in more detail herein.

In various embodiments, the first chamber 410 may have a first plunger 415 and a cavity therein for receiving and dispensing a first fluid. Likewise, the second chamber 420 may have a second plunger 425 and a cavity therein for receiving and dispensing a second fluid. In some embodiments, the diameter of the first chamber 410 may be smaller than the diameter of the second chamber. As described in more detail herein, the second plunger 425 may be actuated by receiving a force in the distal direction. Since the diameter of the second chamber 420 is larger than the diameter of the first chamber 410, the force applied to the second plunger 425, which moves the fluid from the second chamber and into the output section 445, Venturi effect on the fluid in the first chamber, and draws fluid into the output with fluid from the second chamber. In some embodiments, the constant force spring 440 may be configured such that the force exerted on the second plunger 425 is fluid and is uniform so as to cause smooth delivery of the contents of the chambers 410, 420 to the object .

In various embodiments, the syringe system 400 may include a stop 430. In some embodiments, the stop 430 may be configured to block movement of the first plunger 415 after movement over a certain distance has occurred. The position of the stopper 430 may be adjustable by actuating the stopper adjusting screw 435. By changing the positioning of the stop 430, the user can determine the amount of distance that the first plunger 415 can move before it is stopped by the stop. In an exemplary example, a force may be applied to the second plunger 425 to move the first plunger 415 and the second plunger in the respective chambers 410, 420, as described herein, have. Once the first plunger 415 reaches the stop 430, additional distal movement of the first plunger may stop, thereby preventing additional fluid from escaping the first chamber 410, Additional distal movement of the second plunger 425 may continue until all of the contents of the second chamber 420 have been discharged from the second chamber.

Figure 5 shows a side view of yet another alternative syringe according to an embodiment. The syringe 500 may include a syringe body 505 having a proximal end 501 and a distal end 502, similar to the syringe 100 described with reference to Figures 1A and 1B described above. Although the syringe body 505 may have a first plunger 520 and a second plunger 535 disposed therein, as opposed to the embodiment of FIGS. 1A and 1B, Likewise, the second plunger may be located within the first plunger. The first plunger 520 and the second plunger 535 may be moved within the syringe body 505 by applying a force to a portion of the island piece 550 of the piston 545 as described hereinabove.

In various embodiments, the first plunger 520 may form a seal for the interior of the syringe body 505 by the first seal 525, as described herein above. The first chamber 560 may be defined by the first plunger 520 and the tip 510, as described hereinabove. The first chamber 560 can also be configured to receive fluid therein, and as described hereinabove, fluid is forced to move from the tip 510 according to the force exerted on the island piece 550.

In various embodiments, the first plunger 520 may be substantially hollow and may be configured to receive a second plunger 535 and a check valve 523, such as a one-way check valve or the like, within at least the first plunger 520 therein. In some embodiments, the second plunger 535 may form a seal to the interior of the first plunger 520 by a second seal 540. Accordingly, the second chamber 565 can be partitioned by the second plunger 535 and the remainder of the hollow space in the first plunger 520. In addition, the second plunger 535 can be configured to slidably move within the first plunger 520 regardless of the movement of the first plunger within the syringe body 505. In some embodiments, the check valve 523 may be configured to operate to close the opening of the distal portion 521 of the first plunger 520. [ In some embodiments, the check valve 523 may also be configured to be released to discharge the contents of the second chamber 565 into the first chamber 560 and / or into the tip 510. In some embodiments, as described in greater detail herein, fluid is prevented from flowing back into the syringe body when the fluid from the second compartment 565 is discharged, The third seal 524 may allow the distal portion of the first plunger to be sealed against the distal portion of the syringe body 505.

In various embodiments, the second plunger 535 is removably attached to at least a portion of the piston 545. In some embodiments, the second plunger 535 may include a proximally positioned attachment member 537 attached to the second plunger 535. The attachment member 537 of the second plunger 535 may be configured to be removably attached to the attachment member 548 of the piston 545 as a whole.

In various embodiments, the piston 545 may include at least an inner piston 547 and an outer sleeve 546. In some embodiments, the inner piston 547 may extend from the island piece 550 to the attachment member 548. In various embodiments, the inner piston 547 can move independently of the outer sleeve 546 when the inner piston is actuated, so that the attachment member 548 is not in substantial contact with the first plunger 520, Can be attached to the attachment member 537 of the plunger 535 and can be shaped and dimensioned to force the second plunger to move within the first plunger without causing movement of the first plunger within the syringe body 505 Lt; / RTI > In some embodiments, the outer sleeve 546 can be operated independently of the inner piston 547, and can be moved further regardless of the inner piston. In some embodiments, the outer sleeve 546 has a shape and / or size that is configured to contact the outer sleeve with a portion of the proximal end of at least the first plunger 520 without substantial contact with the second plunger 535 Lt; / RTI > In some embodiments, a force may be applied to the outer sleeve 546 to force the outer sleeve to force the first plunger 520 to move within the syringe body 505, as described in more detail herein . In some embodiments, the inner piston 547 and the outer sleeve 546 may be locked together by a locking mechanism (not shown) such that the entire piston 545 moves as one when a force is applied to the island piece 550.

In various embodiments, the syringe body 505 may further include one or more valve actuators 511 located at locations within the interior surface of the syringe body. In this example, the valve actuator 511 is located near the tip 510, but one of ordinary skill in the art will recognize that the valve actuator can be located in any position without departing from the scope of the present invention. In some embodiments, the valve actuator 511 may be configured to release the one-way check valve 523 in accordance with the contact between the valve actuator and the check valve. In some embodiments, the valve actuator 511 may be configured to actuate the check valve 523 in accordance with removal of the contact between the valve actuator and the check valve.

Figures 6A-6D illustrate the movement of various components of the syringe 100 shown in Figures 1A and 1B, according to an embodiment. More particularly, FIG. 6A illustrates the initial state of the syringe 100 when loaded with the first fluid in the first compartment 160 and the second fluid in the second compartment 165. FIG. The user may apply force to the island piece 150 to force the piston 145 into the syringe body 105 in a distal direction, as described herein. As a result, the piston 145 may mechanically direct the second plunger 135 toward the syringe tip 110 in a distal direction. As described hereinabove, the action of the second seal 140 and the first seal 125 may cause the fluid located in the second compartment 165 to leak or not be compressed, but rather to act as a hydraulic lock And transfers the force from the second plunger 135 to the first plunger 120 so that the first plunger also moves in the distal direction toward the syringe tip 110 as shown in Figure 6B. Accordingly, fluid contained in the first compartment 160 can be forced out of the syringe tip 110.

In various embodiments, a mechanical force applied to the piston 145 (a force exerted through the second plunger 135 and from the fluid in the second compartment 165) drives the first plunger into the groove 155 The fluid located in the first compartment 160 can be pushed through the tip 110 by the first plunger 120. [ In some embodiments, in the groove 155, the first seal 125 no longer acts as a fluid seal to the inner surface of the syringe body 105. Fluid in the second compartment 165 flows around the depression 155 and the first compartment 160 is in fluid communication with the first plenum 120. In this state, And then flows out from the tip end 110. [0051] As shown in FIG. 6C shows a cross-sectional view of the syringe 100 when the first seal 125 is in contact with the groove 155 according to various embodiments. In some embodiments, the first seal 125 may contact one or more cops 156, but not one or more total crenels 157 of the depressions 155. Thus, in some embodiments, fluid from the second compartment 165 (FIG. 6B) may flow out of the tip 110 (FIG. 6B) through the total proximal portion 157.

Figure 6d illustrates the result of complete delivery of fluid from both the first compartment 160 and the second compartment 165 by the syringe 100 according to various embodiments. In some embodiments, the island piece 150 could be fully pushed to the end of the finger guard 115. As a result, the piston 145 can be moved to its stroke length, and the second plunger 135 can extend to its most distal position. In some embodiments, as described in more detail herein, the second compartment 165 may be compressed to a minimum volume, and the fluid previously contained therein may pass through the first compartment 160, Lt; RTI ID = 0.0 > 120 < / RTI > 6D shows the residual volume of the second compartment 165 due to the illustrated geometry of the first plunger 120 and the second plunger 135, but when the second plunger fully extends over the circle, It can be understood that two plungers can be fabricated so that the distal surface of the first plunger and the proximal surface of the first plunger form a minimum volume or volume. Figure 6d also shows that at the end of the fluid transfer the connecting piece 130 may be in an un-tensioned state. The connecting piece 130 may be designed to provide a force to the first plunger 120 as the second plunger 135 is drawn toward the proximal end 101 of the syringe body 105 , And may not transmit a force to the first plunger when the second plunger is pushed toward the distal end of the syringe.

In various embodiments, the syringe 100 may be filled by operating in the reverse order of transfer. Thus, in some embodiments, the empty syringe 100 may begin with both the first plunger 120 and the second plunger 135 at the distal end 102 of the syringe 105. In some embodiments, if a user moves the island piece 150 away from the finger guard 115 in a proximal motion, the second fluid may first enter the second compartment 165 from the tip 110. Proximal movement of the island piece 150 may also cause the piston 145 and the mechanically coupled second plunger 135 to move proximally. In some embodiments, the second plunger 135 can be withdrawn proximal into the syringe body 105, tightening the connecting piece 130 tightly. Once the second plunger 135 has been sufficiently moved into the syringe body 105 in the proximal direction (see FIG. 6B), the connecting piece 130 may be pulled tight and additional proximal movement on the piston 145 may be performed by the first plunger 120, respectively. Once the first seal 125 is pulled into the syringe body 105 near the groove 155, the second compartment 165 may be sealed and no additional fluid may enter the second compartment. At this point, the island piece 150 can be further retracted proximal. Once the first seal 125 of the first plunger 120 is coupled to the inner surface of the syringe barrel 105 the first fluid introduced through the tip 110 may be delivered to the first compartment 160 .

Figures 7A-7C illustrate movement of various components of the syringe 200 shown in Figure 2A according to an embodiment. As described in more detail herein, the pressure applied to the island piece 250 may be transmitted to the second plunger 235 through the piston 245. As will be described in greater detail herein, the hydraulic lock will force the first plunger 220 in a distal direction, except for any flow path from the second compartment 265. Therefore, when the valve 275 is in the third or fourth state as shown in FIG. 3, fluid can not be transferred from the second compartment through the delivery tube 270, and in some embodiments, The fluid from the first compartment 260 can be delivered through the tip 210 and the outlet port 280 in a manner similar to the embodiment shown in Figures 1A and 1B . 7B shows the result when the valve 275 is in the second state. In some embodiments, when the valve 275 is in the first or second state (FIG. 3), fluid from the second compartment 265 is directed to the delivery tube 270 And may flow out of the outlet port 280. As a result, the hydraulic lock between the second plunger 235 and the first plunger 220 can be released, and the hydraulic lock between the second plunger 235 and the first plunger 220 can be released, 1 plunger is no longer driven by the second plunger. In some embodiments, since the second plunger 235 can move independently of the first plunger 220, the connecting piece 230 may lose tension, as shown in Figs. 7B and 7C.

In various embodiments, as described herein above, it may be appreciated that the syringe 200 may be filled by operating in the reverse order of transfer. Valve 275 may be adjusted depending on whether it is required to fill first compartment 260 or second compartment 265 and the plunger is forced to move in a proximal direction to cause suction of fluid into each compartment .

Figures 8A-8C illustrate the movement of various components of the syringe 500 shown in Figure 5 according to various embodiments. In some embodiments, the inner piston 547 may be released from the outer sleeve 546 to slide over the circle, and the attachment member 548 of the piston may be in contact with the attachment member 537 of the second plunger 535 And the two attachment members can be locked together. The inner piston 547 and the outer sleeve 546 are configured to move in unison with the force exerted on the island piece 550 to move the first plunger 520 substantially toward the distal end 510 in the distal direction, The inner piston 547 can be locked to the outer sleeve 546. The movement of the first plunger 520 may cause the first fluid contained in the first compartment 560 to exit the tip 510.

In various embodiments, once the first plunger 520 is in contact with the distal portion of the syringe body 505, the second fluid in the second compartment 565 may be prevented from escaping proximally from around the outside of the first plunger The distal portion of the syringe body and the third seal 524 can be formed. In some embodiments, the valve actuator 511 may exert a force upon contact with the check valve 523 to actuate the check valve. In certain embodiments, the valve actuator 511 may apply a force in the proximal direction, thereby forcibly actuating the check valve 523 by moving the check valve proximal into the second compartment 565. By forcing the check valve into the second compartment 565, the passage is opened between the second compartment 565 and the tip 510, thereby causing the second fluid to flow from the second compartment 565 to the tip . In various embodiments, the inner piston 547 can be unlocked once again from the outer sleeve 546 to move independently of the outer sleeve. A force can be applied to the inner piston 547 to move the second plunger 535 in the distal direction within the first plunger 520 so that the second fluid can be forced through the tip 510 into the second compartment & (565).

In various embodiments, as described hereinabove, it can be appreciated that the injector 500 can be filled by operating in the reverse order of transfer. The second plunger 535 may be forced in a proximal direction by the inner piston 547 to draw the second fluid into the second compartment 565. Once the second plunger 535 contacts the proximal portion of the first plunger 520, a proximal force can also pull the first plunger in the proximal direction. Removal of the first plunger 520 from the distal portion of the syringe body 505 may cause the valve actuator 511 to slide the check valve 523 into the circle in the first plunger so that the second compartment 565 ) Is sealed inside thereof. Additional force exerted on the first plunger 520 in the proximal direction may draw the first fluid into the first compartment 560, as described herein above.

Another embodiment of a multi-compartment syringe system includes a syringe body including a hollow lumen and a distal end, the syringe body configured to receive a plurality of fluids therein; A first plunger located within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and to define a first compartment between the distal end of the first plunger and the syringe; A second plunger located proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with the inner wall of the syringe body and form a second compartment between the first plunger and the second plunger; A fluid bypass disposed about the inner wall of the syringe body and around the first plunger at or near the distal end of the syringe body, the fluid bypass, wherein the first fluid can flow into the second compartment through the fluid bypass, Wow; A mechanism for proximal movement of the first plunger to a proximal position relative to the fluid bypass so that the first plunger forms a first seal, the apparatus comprising: a slidable end cap at a distal end of the syringe body; a first plunger in a proximal direction; And at least one magnet in the first plunger, including at least one magnet at or near the distal end of the sleeve, or a sleeve that is magnetically coupled to the ferromagnetic body.

Specific embodiments of multi-compartment syringes are shown in Figures 9a and 9b. According to this embodiment, the syringe 900 may include a reversibly slidable end cap 940 that selectively controls the fluid connection between the first volume compartment 950 and the second volume compartment 955. The syringe includes a cylindrical syringe body 910 having a hollow lumen and a circumferential wall 941 slidably held in the inner wall of the distal end of the syringe body 910 and having a fluid inlet / And an end cap 940 having a syringe tip 942. The syringe tip 942 further includes a conventional connector known in the art such as, for example, a luer connector, for connecting the tip to any conventional fluid delivery device, such as a needle, catheter, or tube . The syringe further includes a distal first plunger 930 and a proximal second plunger 920 and the second plunger 920 is connected to the island piece 965 by a piston 960. [ The area between the second plunger 920 and the first plunger 930 defines the first volume compartment 950 and the area between the first plunger 930 and the end cap 940 is defined by the first plunger 930 ) And the end cap 940 are in the fully distal position (as shown in FIG. 9A), the first plunger 930 (as shown in FIG. 9B) defines the fluid passageway 955 ' When pulled proximally away from the end cap 940, the second volume compartment 955 is defined. 9A also shows a fluid bypass 915 that fluidly connects the passageway 945 with the first volume compartment 950 through the fluid passageway 955 'when the end cap 940 is in the distal position. Applying a proximal force "b" to the island piece 965 moves the piston 960 and the second plunger 920 in a proximal direction so that a first fluid, such as a saline solution, Through the passages 945 and 955 'and the fluid bypass 915 into the first volume compartment 950. According to certain non-limiting embodiments, a fluid bypass, such as, for example, a scallop or a total sagittal groove, may be disposed in a plurality of locations around the inner wall of the syringe body at or near the distal end of the syringe. Once the desired volume of cleaning fluid has been drawn into the first volume compartment 950, a second fluid, such as a medicament solution, such as a medicament, contrast agent, or radiopharmaceutical, is introduced into the second volume compartment 955 , The syringe may be switched to the second mode. Switching to the second mode is accomplished by applying a proximal force "a" to the syringe end cap 940, such as pushing the end cap 940 against the surface. The force "a" causes the end cap 940 and the circumferential wall 941 to slide in the proximal direction to seal against the edge of the inner wall of the syringe body 910 to close the bypass 915 Seal it. The syringe tip 942 is attached to a second fluid source and moves the piston 960 and the second plunger 920 in the proximal direction and also moves the first plunger 930 proximal by a hydraulic force from the hydraulic lock The second fluid is drawn into the volume compartment 955 by applying a proximal force "b" Once the suction of the second fluid has been completed and the desired amount of second fluid has been drawn into the second volume compartment 955, the syringe may be moved to the volume compartment 955 to clean the fluid delivery device and ensure complete delivery of the second fluid. To deliver the second fluid in the volume compartment 950 to the patient and then to deliver the cleaning fluid in the volume compartment 950. 9C, the application of a distal force "b" to the island piece 965 forces the piston 960 and the second plunger 920 in a distal direction to force the first plunger 920, (930) in a distal direction to transfer the second fluid through passage (945). Once the distal edge of the first plunger 930 meets the inner surface of the end cap 940 and the second fluid is substantially delivered through the passageway 945, the first plunger 930 then passes through the end cap 940 (Force "a"), thereby releasing the seal of fluid bypass 915 and opening fluid bypass 915. [ By the continuous application of the distal force to the island piece 965, the cleaning fluid in the volume compartment 950 is transferred through the fluid bypass 915 and the fluid passages 955 ', 945. By this method, various embodiments of the syringe can sequentially suck the cleaning fluid and the medicament, deliver the medicament, and then clean it with the cleaning fluid.

10A and 10B, the syringe 1000 permits sequential aspiration of the cleaning fluid and the medicament, delivery of the medicament, followed by cleaning with the cleaning fluid. According to this embodiment, the syringe 1000 may include a push rod 1080 that selectively controls the fluid connection between the first volume compartment 1050 and the second volume compartment 1055. The syringe includes a cylindrical syringe body 1010 having a hollow lumen and a needle 1042 having a syringe tip 1042 having a pump rod 1080 at the distal end of the syringe body 1010 and having a fluid inlet / - connector 1070. The syringe tip 1042 may be connected to a distal end 1042 of a conventional conventional fluid delivery device known in the art such as, for example, a luer connector, to connect the tip 1042 to any conventional fluid delivery device, such as a needle, catheter, Connector. The syringe further includes a distal first plunger 1030 and a proximal second plunger 1020 and the second plunger 1020 is connected to the island piece 1065 by a piston 1060. [ The area between the second plunger 1020 and the first plunger 1030 defines the first volume compartment 1050 and the area between the first plunger 1030 and the distal end of the syringe is defined by the first plunger 1030, (As shown in FIG. 10A), and the first plunger 1030 is positioned proximal to the distal end of the syringe (as shown in FIG. 10B) The second volume compartment 1055 is partitioned. The T-connector 1070 fluidly connects the fluid passageway 1045 with the fluid inlet 1075. 10A also shows fluid bypass 1015 that fluidly connects channel 1045 with first volume compartment 1050 through fluid channel 1055 'when first plunger 1030 is in the distal position . Applying a proximal force to the island piece 1065 moves the piston 1060 and the second plunger 1020 moves in a proximal direction so that a cleaning fluid, e.g., a first fluid, such as saline, Through the passages 1075, 1045, 1055 'and the fluid bypass 1015 into the first volume compartment 1050. Once the desired volume of cleaning fluid has been drawn into the first volume compartment 1050, a second fluid, such as a medicament solution, such as a medicament, contrast agent, or radiopharmaceutical, is introduced into the second volume compartment 1055 , The syringe may be switched to the second mode. Switching to the second mode is accomplished by applying a proximal force to the push rod 1080. [ The proximal force applied to the push rod 1080 forces the first plunger 1030 in the proximal direction until the sealing means 1035 contacts and seals against the inner wall of the syringe body 1010, The volume compartment 1050 is sealed from the bypass 1015. The syringe tip 1042 is attached to a second fluid source, for example, through a passage 1075 of a T-connector 1070 and moves the piston 1060 and the second plunger 1020 in a proximal direction And the second fluid is drawn into the volume compartment 1055 by applying a proximal force to the island piece 1065 that moves the first plunger 1030 proximally by hydraulic lock. In addition, the second fluid can be drawn into the volume compartment 1050 by pushing the first plunger 1030 with the push rod 1080. The push rod 1080 is sealed with the inner wall of the T-connector 1070 by sealing means 1072 to prevent fluid leakage therethrough. Once the suction of the second fluid is completed and a desired amount of second fluid is drawn into the second volume compartment 1055, the syringe is moved to the volume compartment 1055 To deliver the second fluid in the volume compartment 1050 to the patient, and then to deliver the cleaning fluid in the volume compartment 1050. In one embodiment, the fluid transfer may be via a fluid delivery device attached to the fluid passageway 1075 of the T-connector 1070. In another embodiment, the fluid transfer may be through a fluid delivery device attached to the fluid passageway 1045 after removal of the T-connector 1070. Sequential delivery of the second fluid and the cleaning fluid may be accomplished in a manner similar to the syringe of Figure 9c described herein. That is, application of a distal force to the island piece 1065 forces the piston 1060 and the second plunger 1020 in a distal direction to force the first plunger 1030 in a distal direction, 1042. < / RTI > Once the plunger sealing means 1035 reaches substantially the entirety of the second fluid and reaches the fluid bypass 1015, the volume compartment 1050 is fluidly connected to the fluid bypass 1015 A first cleaning fluid may pass through fluid bypass 1015 and passageways 1055 ', 1045 for simultaneous cleaning of the second fluid from the syringe and fluid delivery device and delivery to the patient.

Another embodiment of a multi-compartment syringe may include a syringe having an array of magnets to control selective aspiration and injection of the first fluid and the second fluid. As shown in FIGS. 11A and 11B, the syringe 1100 permits sequential aspiration of the cleaning fluid and the medicament, delivery of the medicament, followed by cleaning with the cleaning fluid. According to this embodiment, the syringe 1100 selectively controls the fluid connection between the first volume compartment 1150 and the second volume compartment 1155. The syringe includes a cylindrical syringe body 1110 having a hollow lumen and at least one magnet or ferromagnetic body 1180 wrapped around the syringe body 1110 in a distal first plunger 1130 and a proximal second plunger 1120, Includes a sleeve 1170 having at least one magnet 1185 that is self-connected and having a syringe tip 1142 having fluid intake / ejection passageways 1145. The syringe tip 1142 may include a conventional connector known in the art such as, for example, a luer connector, for connecting the tip to any conventional fluid delivery device, such as a needle, catheter, or tube, . The second plunger 1120 may be connected to the island piece 1165 by a piston 1160. The area between the second plunger 1120 and the first plunger 1130 defines the first volume compartment 1150 and the area between the first plunger 1130 and the distal end of the syringe is defined by the first plunger 1130, (As shown in Fig. 11A), and the first plunger 1130 is located proximal to the distal end of the syringe (as shown in Fig. ≪ RTI ID = 0.0 > 11B) Lt; RTI ID = 0.0 > 1155 < / RTI > Sleeve 1170 surrounds the outer body of syringe 1110 and is coupled to one or more magnets or one ferromagnetic body 1180 that is magnetically coupled to one or more magnets 1180 inside one or both of first plunger 1130 and second plunger 1120 Or more magnets 1185 and / or 1185 '. 11A also shows fluid bypass 1115 that fluidly connects channel 1145 to first volume compartment 1150 through fluid channel 1155 'when first plunger 1130 is in the distal position . Applying a proximal force to the island piece 1165 moves the piston 1160 and the second plunger 1120 in a proximal direction so that a first fluid, such as a cleaning fluid, e.g., saline, , 1155 ', and fluid bypass 1115 into the first volume compartment 1150. Once the desired volume of cleaning fluid has been drawn into the first volume compartment 1150, a second fluid, such as a medicament solution, such as a medicament, contrast agent, or radiopharmaceutical, is introduced into the second volume compartment 1155 , The syringe may be switched to the second mode. Switching to the second mode may be accomplished, for example, by the user manually pulling the sleeve 1170 in the proximal direction or by moving the proximal magnet 1185 'from the magnet 1180 of the second plunger 1120, , By sliding the sleeve 1170 in the proximal direction. The distal magnet 1185 of the sleeve 1170 is magnetically coupled to the distal magnet or ferromagnetic body 1180 in the first plunger 1130 and the sealing means 1135 contacts the edge of the inner wall of the syringe body 1110 to seal The proximal movement of the sleeve 1170 also moves the first plunger 1130 in the proximal direction and thereby seals the volume compartment 1150 from the bypass 1115. In certain embodiments, proximal magnet 1185 'in sleeve 1170 may be magnetically coupled to a magnet or ferromagnetic body 1180 in second plunger 1130 and as second plunger 1130 is pulled in the proximal direction Movement of the sleeve 1170 in the proximal direction may be affected. The syringe tip 1142 is then attached to the second fluid source and moves the piston 1160 and the second plunger 1120 in the proximal direction and also moves the first plunger 1130 proximal By applying a proximal force to the island piece 1165, the second fluid is drawn into the volume compartment 1155. The volume of the first fluid within the volume compartment 1150 may be determined by the relative distance between the distal magnet 1185 and the proximal magnet 1185 'on the sleeve 1170. In other embodiments, According to this embodiment, the first plunger 1130 is in a fully distal position (as shown in FIG. 11a), and the second plunger 1120 also contacts the first plunger and is in a fully distal position. As the island piece 1165 is pulled proximally, the first plunger 1120 is pulled in the proximal direction to fill the volume compartment 1150 with the first fluid. When the magnet or ferromagnetic body 1180 of the second plunger 1120 reaches the position of the proximal magnet 1185 'of the sleeve 1170, a magnetic attraction is formed and an additional proximal withdrawal of the second plunger 1120 also occurs, Causing the first plunger 1170 to be withdrawn proximally to cause the first plunger 1130 to move proximally past the fluid bypass 1115 so that the second fluid can flow into the volume chamber 1155 ). In a further embodiment, the volume of the first fluid introduced into the syringe 1100 relative to the volume of the second fluid can be controlled by varying the distance between the proximal magnet 1185 'and the distal magnet 1185. For example, according to one embodiment, the sleeve 1170 may include a threaded attachment portion that can be pivoted clockwise or counterclockwise to lengthen or shorten the distance between the magnets 1185, 1185 ' 1185 ', such as between the distal and proximal portions of the first and second plunger magnets 1170, 1170. Thus, the first and second plunger magnets or ferromagnets 1180 Are connected to the sleeve magnets 1185 and 1185 ', respectively, the volume of the volume compartment 1150 can be made larger or smaller. Once the suction of the second fluid is completed and a desired amount of second fluid is drawn into the second volume compartment 1155, the syringe is moved to the volume compartment 1155 to clean the fluid delivery device and ensure complete delivery of the second fluid To deliver the second fluid in the volume compartment 1150 to the patient, and then to deliver the cleaning fluid in the volume compartment 1150. Fluid delivery may be accomplished through a fluid delivery device attached to fluid passage 1145. [ Sequential delivery of the second fluid and the cleaning fluid may be accomplished in a manner similar to the syringe of Figure 9c described herein. That is, the application of the distal force to the island piece 1165 pushes the piston 1160 and the second plunger 1120 in a distal direction to engage the first plunger 1120 using a hydraulic lock and / Thereby forcing the second fluid to pass through the passageway 1145. In this way, Once the plunger sealing means 1135 reaches substantially the entirety of the second fluid and reaches the fluid bypass 1115, the volume compartment 1150 is fluidly connected to the fluid bypass 1115 The first cleaning fluid may pass through fluid bypass 1115 and passages 1155 ', 1145 for simultaneous cleaning of the second fluid from the syringe and fluid delivery device and delivery to the patient. In such an embodiment involving magnets and ferromagnets, it will be understood that the replacement of the relative positions of magnets and ferromagnets is within the scope of the present invention.

While various embodiments have been described in detail for purposes of illustration, it is to be understood that such detail is solely for purposes of illustration and that the invention is not limited to the disclosed embodiments, but on the contrary, is intended to cover modifications and equivalent arrangements will be. For example, it will be appreciated that the present invention contemplates that, to the extent possible, one or more features of any embodiment may be combined with one or more features of any other embodiment.

Claims (26)

A syringe body including a hollow lumen and a distal end, the syringe body configured to receive a plurality of fluids therein;
A first plunger positioned within the hollow lumen of the syringe body for forming a first seal with an inner wall of the syringe body and defining a first compartment between the distal end of the first plunger and the syringe;
A second plunger positioned proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with an inner wall of the syringe body; and a second seal between the first plunger and the second plunger, A second plunger forming a compartment;
A fluid bypass disposed about the inner wall of the syringe body and around the first plunger at or near the distal end of the syringe body, wherein a first fluid can flow into the second compartment through the fluid bypass A fluid bypass; And
A mechanism for proximal movement of the first plunger to a proximal position relative to the fluid bypass so that the first plunger forms the first seal, the mechanism comprising: a slidable end cap at a distal end of the syringe body; A push rod configured to push the first plunger in a proximal direction and at least one magnet in the first plunger including at least one magnet at or near the distal end of the sleeve, The syringe system comprising: The method according to claim 1,
Wherein the device includes a slidable end cap having a circumferential wall including the inner wall at a distal end of the syringe body. 3. The method of claim 2,
Wherein applying a proximal force to the slidable end cap causes the end cap to slide proximally to fluid seal the fluid bypass. The method according to claim 1,
The mechanism further comprising a T-connector including the pushrod and connected to a distal end of the syringe body for directing the push rod into the first compartment for connection with the first plunger. 5. The method of claim 4,
Wherein the T-connector is fluidly connected to at least one fluid source. The method according to claim 1,
Wherein the mechanism comprises the sleeve including the at least one magnet at or near the distal end of the sleeve, and wherein sliding the sleeve in a proximal direction comprises sliding the first plunger in a proximal direction, system. The method according to claim 6,
Wherein the sleeve is configured to slide by applying a proximal force to the outer wall of the sleeve. The method according to claim 6,
Further comprising at least one proximal magnet located at or near the proximal end of the sleeve and adapted to be magnetically coupled to the magnet or ferromagnetic within the second plunger. 9. The method of claim 8,
Wherein movement in the proximal direction of the second plunger causes the sleeve and the first plunger to move in a proximal direction when the at least one proximal magnet is magnetically coupled to the magnet or ferromagnetic in the second plunger. The method according to claim 1,
Further comprising a piston connected to the second plunger, wherein the piston is configured to be actuated by a thumb piece. The method according to claim 1,
Wherein the first compartment includes a contrast agent therein, and wherein the second compartment includes a cleaning fluid therein. A syringe body including a hollow lumen and a distal end including a syringe tip, the syringe body configured to receive a plurality of fluids therein;
A first plunger positioned within the hollow lumen of the syringe body for forming a first seal with an inner wall of the syringe body and defining a first compartment between the distal end of the first plunger and the syringe;
A second plunger positioned proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with an inner wall of the syringe body; and a second seal between the first plunger and the second plunger, A second plunger forming a compartment; And
And a delivery tube in fluid communication with the second compartment and the syringe tip. 13. The method of claim 12,
Wherein the delivery tube includes a valve in fluid communication with the syringe tip. 14. The method of claim 13,
Further comprising an outlet port fluidly connected to the outlet of the valve. 15. The method of claim 14,
Wherein the outlet port is configured to output fluid from at least one of the first compartment and the second compartment in accordance with the orientation of the valve. 16. The method of claim 15,
Wherein the orientation of the valve comprises a first open state for allowing fluid to flow from the syringe tip to the outlet port, a second open state for allowing fluid to flow from the delivery tube to the outlet port, A third open state to allow fluid to flow from all of the tubes to the outlet port, and a closed state to block flow of fluid from the syringe tip and the delivery tube. 13. The method of claim 12,
Further comprising a plurality of recesses disposed about an inner wall of the syringe body near the distal end of the syringe body. 18. The method of claim 17,
Wherein the plurality of recesses are scalloped or crenelated. 18. The method of claim 17,
The first plunger breaking the first seal with the inner wall of the syringe body as it contacts the plurality of recesses to cause fluid content of the second compartment to flow into the circle into the first compartment, . 13. The method of claim 12,
Further comprising a piston connected to the second plunger, wherein the piston is configured to be actuated by a thumb piece. A syringe body including a hollow lumen and a distal end including a syringe tip, the syringe body configured to receive a plurality of fluids therein;
A first plunger positioned within the hollow lumen of the syringe body for forming a first seal with an inner wall of the syringe body and defining a first compartment between the distal end of the first plunger and the syringe;
A second plunger positioned proximal to the first plunger within the hollow lumen of the syringe body to form a second seal with an inner wall of the syringe body; and a second seal between the first plunger and the second plunger, A second plunger forming a compartment;
A delivery tube in fluid communication with the second compartment, the delivery tube including a valve having an outlet, the valve being in fluid communication with the syringe tip; And
And an outlet port fluidly connected to the outlet of the valve,
Wherein the orientation of the valve comprises a first open state for allowing fluid to flow from the syringe tip to the outlet port, a second open state for allowing fluid to flow from the delivery tube to the outlet port, A third open state to allow fluid to flow from all of the tubes to the outlet port, and a closed state to block flow of fluid from the syringe tip and the delivery tube. A syringe body including a hollow lumen and a distal end, the syringe body configured to receive a plurality of fluids therein;
A first plunger positioned within the hollow lumen of the syringe body to form a first seal with the inner wall of the syringe body and form a first compartment between the distal end of the first plunger and the syringe, A first plunger including a hollow lumen; And
A second plunger positioned within the hollow lumen of the first plunger and defining a second seal with an inner wall of the first plunger and a second plunger defining a second compartment between the first plunger and the second plunger, ≪ / RTI > 23. The method of claim 22,
Further comprising a check valve located within a distal opening in the hollow lumen of the first plunger, the check valve configured to discharge the contents of the second compartment when actuated. 23. The method of claim 22,
Wherein the inner piston is removably connected to the second plunger, the outer sleeve is removably connected to the first plunger, and the inner piston comprises a piston having an inner piston and an outer sleeve, And is configured to move independently of the outer sleeve or to be submerged in the outer sleeve such that the outer sleeve is moved in unison. 25. The method of claim 24,
Wherein the piston is configured to be actuated by a thumbpiece. 23. The method of claim 22,
Wherein the first compartment includes a contrast agent therein, and wherein the second compartment includes a cleaning fluid therein.

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