KR20150123988A - Fluoride Varnish Composition Containing Natural Extract - Google Patents

Abstract

The present invention relates to a fluoride varnish composition containing a resin, a solvent, and a fluoride compound. The fluoride varnish composition further contains a natural extract having an antibacterial activity against harmful bacteria in the mouth.

Description

FIELD OF THE INVENTION The present invention relates to a fluoride coating composition containing a natural extract,

The present invention relates to a fluorine coating composition comprising Resin, a solvent, a fluorine compound and a natural extract.

Dental caries is a dental plaque in which oral bacteria accumulate. The bacteria decompose the nutrients (especially monosaccharides) ingested by the host to form acids, and these acids form calcium salts To cause defects in the chemical structure.

Lactic acid is a very small molecule that can penetrate into the enamel structure of teeth and cause a serious reaction in the enamel with relatively low fluoride content. This reaction demineralizes the calcium salt beneath the surface of the tooth and creates a microscopic hole at the surface of the tooth that is larger than at the surface of the tooth and is called a white spot lesion. As the demineralization progresses inside the enamel, the tooth becomes a carious tooth.

If the mechanism of dental caries is decalcified, the preventive mechanism is remineralization, and it is possible to prevent the occurrence mechanism or remission of the early dental caries by remineralization, Can be suppressed.

A representative method used for the purpose of preventing and inhibiting dental caries is to use a material or material containing fluorine. Since fluoride application in the oral cavity promotes remineralization of demineralized enamel, it greatly contributes to the symptom of the teeth (retarded sensation) and the prevention of tooth decay (prevention of tooth caries), and the fluoride film is formed in the tooth, Prevention, and strengthening the process of bonding minerals such as calcium plays a role.

The mechanism of prevention or inhibition of dental caries in fluoride is effective especially for fluorine-containing dentures. When fluorine is included in the crystal structure of enamel during the formation of fluoride, it is called fluoroapatite The surface of the enamel surrounded by body fluids is filled with a large amount of fluoride, so that the concentration of fluorine rapidly increases and the concentration of fluorine increases, so that the apatite, which is the crystal structure of the tooth surface, More stable.

In the case of sex inches (permanent teeth), fluorine acts on dental caries-inducing bacteria in the oral cavity to inhibit bacteria from producing acidic substances and to increase the resistance of the teeth to acid, And helps the demineralized tooth surface to be remineralized.

According to the data of the Oral Health Program of the Ministry of Health and Welfare in 2007, the representative oral care products using fluoride are divided into four categories and they are controlled by fluoride detergent (such as toothpaste containing fluoride), fluoride solution toothpaste Fluoride gels (products that use fluoride gels in their mouths) and fluoride coatings (products that are coated with natural rosin and rosin to keep fluoride on the tooth surface for a long time).

Among these four categories, the most effective prevention of tooth decay of fluoride coatings is that the tooth decay prevention effect is twice as high as that of the previously used fluoride gels and about 10% The researchers said.

Fluoride application indications (diseases or symptoms requiring treatment effects such as any medicines or surgery) include toothbrushing, tooth decay, early childhood infants, early childhood dental checkups, When you want to prevent tooth decay on the adjacent tooth between tooth and tooth, prevent tooth decay of fresh teeth, prevent tooth decay in orthodontic patients, prevent tooth decay when you wear implants or other prostheses, It is used when the root is exposed, when it is crushed after scaling, when it is crushed after the whitening treatment, when the tooth is demineralized as a whole and when it is difficult to treat properly.

However, the conventional fluoride coating agent can prevent dental caries due to the remineralization action of fluorine, but there is a problem in that it does not remove harmful bacteria in the oral cavity that provide the root cause of dental caries.

Therefore, there is a high need for a technique capable of satisfying the intrinsic requirement of fluoride supply in the oral cavity, as well as removing harmful bacteria in the oral cavity, which is the root cause of dental caries.

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above-mentioned problems of the prior art and the technical problems required from the past.

The inventors of the present application have conducted intensive research and various experiments, and have found that, as will be described later, the fluorine coating composition containing a resin, a solvent, and a fluorine compound is a natural The present invention has been accomplished on the basis of confirming that the above-mentioned desired effect can be achieved when an extract is further contained.

Accordingly, the present invention is a fluorine coating composition comprising a resin, a solvent and a fluorine compound, wherein the fluorine coating composition further comprises a natural extract exhibiting antibacterial activity against harmful bacteria in the mouth.

When the fluoride coating composition as described above is used, it is possible to prevent dental caries due to the remineralizing action of fluorine, as well as the action of a natural extract showing antimicrobial action against harmful bacteria in the oral cavity. As a result, , Thereby significantly reducing the possibility of dental caries.

In one specific example, the harmful bacterium may be Streptococcus mutans .

On the other hand, the natural extract which shows antimicrobial activity against the harmful bacteria effectively removes bacteria in the oral cavity, and has no side effects on the human body. It is particularly limited if it exhibits the growth inhibitory activity against Streptococcus mutans and the active oxygen species- But are not limited to, for example, phragmites extract, grapefruit seed extract, Cryptomeria japonica extract, Angelica japonica extract, cinnamon extract, algae extract, cocoa extract, palm cactus extract, green tea extract, black tea extract, oolong tea extract, L.) extract, Sparganium stoloniferum extract, or a mixture of Cryptomeria japonica extract and Black ginseng extract. In particular, the extract may be a combination of a Cabbage tree extract, a black ginseng extract, or a combination of a Cabbage tree extract and a Black ginseng extract.

It is used as a medicinal herb. Especially, it has been used as a medicinal herb, and has been widely used as a medicinal herb, in particular, as a medicinal herb, hematocrit, colitis, dysentery, hypertension, nervous breakdown, insomnia, Constipation and other symptoms were used as a remedy or remedy. In addition, the black ginseng was used as a herb of the black ginseng seed, and the black ginseng outpost was used as a medicinal herb. In the past, abdominal pain, menstrual irregularity, menstrual pain, menstrual occlusion, , Cervical cancer, breast cancer, rectal cancer, lung cancer, cerebral thrombosis, brain color, cerebral hemorrhage, and cardiac pain.

Thus, although various pharmacological activities have been reported for natural materials such as leaves and fruits of Quercus serrata and black ginseng, there is still a report and research on the antimicrobial activity against the harmful bacteria in the oral cavity and the antioxidant activity against the active oxygen species Is not available.

As a result of intensive research conducted by the inventors of the present application, it has been confirmed that the extracts of Cryptomeria japonica and Ginseng extract contain a large amount of polyphenols and flavonoids. Therefore, the antimicrobial activity against harmful bacteria in the oral cavity, It has an antioxidant effect on the species.

Particularly, it has been confirmed that polyphenol among the substances contained in the extracts of P. vivax and P. ginseng extract can partially inhibit the production of the biofilm-forming substance of Streptococcus mutans and exhibit antimicrobial activity.

In one specific example, the content of the natural extract to exhibit such an effect may be 0.01 to 1% by weight, more specifically 0.1 to 0.5% by weight, based on the total weight of the fluorochemical coating composition.

When the content of the natural extract is less than 0.01% by weight, antibacterial activity against noxious bacteria is insufficient and it is difficult to achieve the purpose of removing noxious bacteria. When the content of the natural extract is more than 1% by weight, properties of the fluorochemical coating composition such as workability, So that it is undesirable.

As described above, the natural extract may be a mixture of a Cabbage tree extract and a Black ginseng extract. In this case, the mixing ratio of the Cabbage tree extract to the Black ginseng extract may be 1 to 99: 1 to 99.

The natural extract according to the present invention can be prepared by adding a natural material to water or alcohol and heating to obtain an extract, and concentrating the extract.

For example, 150 g of the dried natural material is placed in an extraction bottle, distilled water is added in a volume of 2 to 10 times that of the natural material, and the mixture is heated at 80 to 121 ° C for 5 hours for extraction Is repeated 3 times to obtain an extract. Further, 150 g of the dried natural material was placed in ethanol or methanol having a concentration of 95 to 99% of 1 to 15 times the volume of the natural material, heated in an extractor equipped with a cooling condenser at 50 to 80 ° C for 12 to 24 hours, Can be obtained. The extract obtained by this method is further subjected to filtration under reduced pressure to remove solids, and the filtrate is concentrated under reduced pressure at a concentration of 50 to 90 brix in a condenser equipped with a cooling condenser, followed by lyophilization, thereby preparing a natural extract.

The natural material may be one or two or more selected from the group consisting of leaves, fruits, and stem of a spruce tree, or may be a black gruel discharge.

On the other hand, rosin, which is a kind of resin which is a base material of the fluorine coating composition, has a high safety, a tackiness-imparting effect and a high compatibility with various elastic resins. However, abietic acid, which is a main component of rosin, Due to the presence of conjugated double bonds, it is possible to react with oxygen in the air to cause coloring defects over time. Also, because the color is light yellow to brown, there may be restrictions on the applications in which panning is required.

Therefore, it is possible to use unstable abietic acid, palustric acid, neoabietic acid, and the like, which are frequently contained in chromosomal aberrations, as dihydroabietic acid, dihydroabietic acid, Hydrogenated rosin or Hydrogenated rosin has been developed which is converted into Tetrahydroabietic acid or the like. The rosin, which has undergone such a change process, is chemically stabilized by the loss of the aromatic nucleus in its molecule or its resonance structure.

Dehydrogenation and hydrogenation of rosin are not significantly different from those of the original rosin. The rosin has an acid number of about 170 or higher and a high softening point, so that various carboxylic acids It is often used by substitution (esterification).

The alcohol group used herein is methanol, methanol, triethylene glycol, a dihydric alcohol, glycerol, a trihydric alcohol, and pentaerythriol, a dihydric alcohol. Ester-form rosin prepared from these have characteristics of liquid rosin, semi-solid, solid (softening point 80 ° C), and solid (softening point 100 ° C). Therefore, the esterification of rosin lowers softening point, volatility, acid value, and improves chemical stability and oxidation stability.

Therefore, the resin according to the present invention is not particularly limited as long as it is capable of exerting an adhesive force with a tooth as a medical and food material and is soluble in a solvent, and may be a gum rosin or a woodrod resin, Dehydrogenated Rosin, Ester of Hydrogenated Rosin, Fully Hydrogenated Rosin, Partially Hydrogenated Rosin, Dimerized Rosin, Dehydrogenated Rosin, ), And a hydrocarbon resin (hydrocarbon resin) material.

The content of the chromophoric or woody resin may be 30 to 80% by weight, and more preferably 40 to 70% by weight based on the total weight of the composition.

 When the content is less than 30% by weight based on the total weight of the composition, it is difficult to provide sufficient adhesion and spreadability, and fluorine is not easily mixed and supported. When the content is more than 80% by weight, the viscosity and workability And the fluorine releasing ability may also be lowered.

On the other hand, when the resin is a mixture of a hydrogenated rosin ester, a completely hydrogenated rosin, and a partially hydrogenated rosin, the hydrogenated rosin ester, completely hydrogenated rosin and partially hydrogenated rosin And may be contained in a ratio of 0.2 to 2: 1 to 3: 0.2 to 2 on a weight basis. However, the present invention is not limited thereto, and can be appropriately combined in consideration of initial adhesion, adhesion, cohesion, solubility, and removal ability of the desired fluorine-containing agent.

The solvent may be volatile solvents and may be, for example, ethanol, isopropyl alcohol, acetone, benzene, cyclohexane, toluene, n-pentane, n-hexane, And isopropyl acetate. However, the present invention is not limited thereto.

The fluoride coating composition forms a thin film in the oral cavity due to volatilization of the solvent, and affects the coating property, the film formation degree, and the dispersibility depending on the content of the solvent. The content of the solvent is based on the total weight of the composition 10 to 60% by weight, and more specifically, 20 to 50% by weight.

The fluorine compound is not particularly limited as long as it is not toxic to the human body and can emit fluorine, and examples thereof include sodium fluoride (NaF), sodium fluorophosphate (Na ₂ PFO ₃ ), tin fluoride (SnF ₂ ) (BF ₃ ), zinc fluoride (ZnF ₂ ), potassium fluoride (KF), calcium fluoride (CaF ₂ ), zirconium tetrafluoride (ZrF ₄ ), hexafluorosilicate (H ₂ SiF ₆ ), and sodium hexafluorosilicate ₂ SiF < ₆ >).

The fluorine provided by the fluorine compound promotes the remineralization of the decolorized enamel. In addition, when fluoride ion is intercalated into the hydroxyl ion site of the hydroxyapatite, which is the main component of the tooth, fluoride apatite harder than hydroxyapatite is formed on the tooth surface, thereby preventing loss of minerals from enamel to prevent decay and prevent tooth decay .

Such a fluorine compound may be 1 to 10% by weight, more specifically 2 to 8% by weight, based on the total weight of the composition, considering the content relationship with resin, solvent and natural extract.

If the average particle diameter of the fluorine compound is less than 0.005 mu m, it may be difficult to uniformly disperse the fluorine compound in the fluorine coating composition due to the cohesive force between the particles, If the particle size is larger than 100 m, the applicability of the fluoride coating agent is decreased, which makes it difficult for the practitioner to apply to the teeth, and the possibility that the fluoride compound particles are lost due to the saliva or tongue after application increases and the fluoride release may be reduced.

On the other hand, in addition to the above composition, an additive may be further included in order to implement the fluorine coating composition, and the additive may be, for example, an emulsifier, an adhesive material, a thickener, a sweetener, and a perfume.

As the emulsifier, a polyoxyethylene-based material may be used. Specifically, the emulsifier may be one or two or more selected from the group consisting of polysorbate 20, polysorbate 40, polysorbate 60 and polysorbate 80, But is not limited thereto.

When the emulsifier is included, the content thereof may be 0.01 to 3% by weight, more specifically 0.1 to 2% by weight, based on the total weight of the fluorochemical coating composition.

The adhesive material may provide tooth adhesion, exhibit dental adhesiveness when dissolved in a solvent, and may be coated on the tooth surface to form a film. Examples of the adhesive material include hydroxypropyl methylcellulose, Hydroxyethyl cellulose, hydroxypropyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, carbomer, and polyvinyl acetate. In addition, , But it is not limited thereto.

The adhesive material may be 0.01 to 5% by weight, more specifically 0.1 to 3% by weight, based on the total weight of the fluorochemical coating composition.

In addition, the adhesive material can be appropriately selected in consideration of the viscosity of the fluorochemical coating agent, the solubility of the solvent, the coating property, etc. Particularly, polyvinylpyrrolidone and vinyl acetate resin are generally used. 25 to 35 and a molecular weight of 40,000 to 50,000, so that they have similar viscosity and molecular weight.

It is necessary to have an appropriate viscosity to improve the application and stability of the fluorine coating composition and to increase the viscosity by adding a thickener when an excessive amount of solvent is used or when the viscosity is somewhat low for other reasons.

The thickening agent may be one or more selected from the group consisting of silica filler, xanthan gum and cellulose derivative, but is not limited thereto.

Since the above-mentioned thickeners have different solubility in solvents, excessive use of the thickeners may degrade the action mechanism of the fluorochemical coating agent. Therefore, an appropriate thickener content is required depending on the content of the other composition of the fluorochemical coating agent. Specifically, 0.1 to 5% by weight, and more specifically, 1 to 4% by weight.

The above sweetener can control the taste rejected in the oral cavity such as spicy taste and bitter taste by other composition to a sweet taste to reduce the feeling of refusal when applying the fluorochemical coating agent. For example, it is possible to control the taste of the sweetener such as Sucrose, Acesulfame Potassium, Aspartame, Salt of Aspartame Acesulfame, Sodium Cyclamate, Dulcin, Neotame, P-400, Saccharin, Sorbitol, Sucralose, Stevioside, And xylitol, but is not limited thereto.

The sweeteners are different in sweetness, and an appropriate sweetener content is required according to the content of the other composition of the fluorine coating agent. Specifically, the sweeteners may be 1 to 5% by weight, and more specifically 2 to 4% have.

The fragrance reduces the feeling of rejection to the patient due to the resin composition, solvent, etc. by other compositions contained in the fluoride coating composition, and is particularly effective in reducing the rejection of pediatric patients.

The fragrance is not particularly limited as long as it is harmless to the human body and can reduce the patient's feeling of rejection. Examples of the fragrance include bubble gum, mint flavor, strawberry flavor, Selected from the group consisting of Melon, Cherry, Raspberry, Spearmint, Peppermint, Watermelon, Caramel, and Vanilla. One or two or more.

The fragrances are different in their fragrance and an appropriate perfume content is required according to the content of the other composition of the fluorine coating agent. Specifically, the fragrance may be 1 to 5 wt%, and more specifically 2 to 4 wt% have.

Meanwhile, the fluoride coating composition according to the present invention can be used variously as a dental material. For example, the fluoride coating composition according to the present invention can be used as a dental material such as a desensitizer, a cavity base, Cavity liner, Cavity varnish, and coating agent.

The supraorbital agent is a material used to treat the hypersensitivity reaction of the teeth. The vortex base is a material that forms on the dimension surface after the cavity is formed, and forms a heat block effect and a vortex shape. The material to be applied to the posterior surface is a material having a pharmacological action, and the vortex varnish is a material applied to the surface after the cavity is formed, and serves as a separation membrane without pharmacological action. Further, the coating agent refers to a substance which is coated with a base material by mixing various functional materials with teeth, and for example, there is a tooth whitening agent which mixes a whitening ingredient with a base material and coating the same on the teeth.

The present invention also provides a natural extract showing antimicrobial action against harmful bacteria in the mouth, as a mixture of Thuja orientalis L. extract, Sparganium stoloniferum extract, or Cabbage tree extract and Black ginseng extract.

As described above, the natural extract may be a mixture of a Cabbage tree extract and a Black ginseng extract. In this case, the mixing ratio of the Cabbage tree extract to the Black ginseng extract may be 1 to 99: 1 to 99.

Further, as described above, the harmful bacterium may be Streptococcus mutans .

As described above, the fluorochemical coating composition according to the present invention is capable of preventing dental caries due to the remineralizing action of fluorine, as well as the action of a natural extract showing antimicrobial action against harmful bacteria in the oral cavity, It is effective to remove the harmful bacteria causing the dental caries, thereby significantly reducing the possibility of dental caries.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a photograph showing the antibacterial evaluation result of the fluorochemical coating composition according to Example 1 of the present invention; FIG.
2 is a photograph showing the results of the antibacterial evaluation of the fluorochemical coating composition according to Example 2 of the present invention;
3 is a photograph showing the result of antibacterial evaluation of the fluorochemical coating composition according to Example 3 of the present invention;
4 is a photograph showing the antibacterial evaluation result of the fluorochemical coating composition according to Example 4 of the present invention;
FIG. 5 is a photograph showing the antibacterial evaluation result of the fluorochemical coating composition according to Example 5 of the present invention; FIG.
FIG. 6 is a photograph showing the antibacterial evaluation result of the fluorochemical coating composition according to Example 6 of the present invention; FIG.
7 is a photograph showing the result of antibacterial evaluation of a fluorochemical coating composition containing no natural extract of Comparative Example 1. Fig.

Hereinafter, an embodiment of the present invention will be described, but it is to be understood that the scope of the present invention is not limited thereto.

≪ Preparation Example 1 &

Manufacture of Cryptomeria japonica Extract

The extracts were prepared by extracting 30 g of cinnabia leaves and fruit in an extraction bottle and adding 300 ml of 95% alcohol at 50 ° C for 24 hours. The extract was filtered under reduced pressure to remove solids, The concentrate was concentrated under reduced pressure and lyophilized to prepare a Leaf Extract.

≪ Preparation Example 2 &

Preparation method of black ginseng extract

Black ginseng extract The black ginseng extract was prepared in the same manner as in Preparation Example 1, except that 30 g of the black ginseng outpost was placed in the extraction bottle.

≪ Example 1 >

The fluoro coating composition according to the present invention was prepared by using the following extracts of the above-mentioned Synthetic tree.

<Table 1>

&Lt; Example 2 >

A fluororesin coating composition was prepared in the same manner as in Example 1, except that in Example 1, 0.5% by weight of Cranberry extract and 30.0% by weight of complete hydrogenated sebaceous ginseng were used.

&Lt; Example 3 >

A fluorochemical coating composition was prepared in the same manner as in Example 1, except that 0.2% by weight of the extract of P. vannamei prepared in Preparation Example 2 was used.

<Example 4>

In Example 3, a fluorochemical coating composition was prepared in the same manner as in Example 3, except that the black ginseng extract was changed to 0.5 wt% and the total hydrogenated sebacic acid was replaced with 30.0 wt%.

&Lt; Example 5 >

A fluororescing agent composition was prepared in the same manner as in Example 1, except that 0.1% by weight of Cinnabar extracts and 0.1% by weight of the black ginseng extract prepared in Preparation Example 2 were used in Example 1 .

&Lt; Example 6 >

Except that 0.25% by weight of Cranberry extract and 30% by weight of completely hydrogenated sebaceous rosin were used in Example 1 and 0.25% by weight of the black ginseng extract prepared in Preparation Example 2 was added. The fluororesin coating composition was prepared.

&Lt; Comparative Example 1 &

A fluororescing agent composition was prepared in the same manner as in Example 1, except that the natural extract was not added in Example 1, and the total hydrogenated hydrocolloid was 30.5% by weight.

<Experimental Example 1>

Antibacterial evaluation of a total of 7 fluoride coating compositions prepared through Examples 1 to 6 and Comparative Example 1 was carried out. The antibacterial evaluation was carried out through a radial diffusion assay in which a round groove was formed at the center of the solid medium, the groove was filled with the solid fluorine coating composition, and the antibacterial range was measured.

The target strain, Streptococcus mutans, used KCTC3065, distributed from KCTC (Korean Collection for Type Cultures), and Streptococcus mutans was cultivated in medium of brain heart infusion (sheep brain and heart extract 37%) And cultured at 37 ° C under aerobic conditions for 24 to 48 hours. The cultured strains were each inoculated in 0.8% agarose medium at 40 ° C to give a concentration of 1 × 10 6 cells / ml, and a solid medium was prepared. A circular groove was formed in the center of the solid medium and filled with the fluoride composition. The diameter of the clear zone (the area where the germ growth was inhibited and the bacteria did not grow) was measured in mm in an optimal culture condition after hardening for about 1 hour. The results are shown in Table 2 and Figs. 1 to 7.

<Experimental Example 2>

The total fluorine content of a total of 7 fluoride coating compositions prepared from Examples 1 to 6 and Comparative Example 1 was determined according to Caries Res. 48 (4): 306-311. The results are shown in Table 2.

<Experimental Example 3>

Fluoride release behaviors of the total of 7 fluorine coating compositions prepared through Examples 1 to 6 and Comparative Example 1 after 4 hours were evaluated.

After 4 hours, the fluorine releasing behavior was uniformly applied to the surface of the slide glass, dried, immersed in 10 ml of distilled water, sealed, and stored in a shaking oven (37 ° C, 100 rpm) for 4 hours . Then, 2 ml of the eluate was collected, and then 2 ml of total ion sensitivity control buffer (TISAB) was added to stabilize the eluent and remove the fluorine fluoride, and the mixture was stirred at a constant speed on a magnetic stirrer. After measuring the mV value of the effluent stabilized at room temperature, the fluoride ion concentration was calculated using the standard calibration curve prepared by measuring the mV of the standard solutions having the fluorine ion concentrations of 1 ppm, 10 ppm, and 100 ppm in advance. The results are shown in Table 2.

<Experimental Example 4>

The dentin capillary barrier capacity and surface hardness changes of the five fluorine coating agents prepared in Examples 1 to 4 and Comparative Example 1 were measured. After the dentin of the premolar without dental caries was exposed, 35% phosphoric acid was acid-etched on the surface for 10 seconds and then rinsed with water for 20 seconds. The acid-etched dentin surface was coated / cured with a fluorochemical agent and kept at 37 ° C and 100% relative humidity for 4 hours and stored at 37 ° C in distilled water for 24 hours. The surface of the dentin specimen was coated with OsO ₄ and the degree of occlusion of the dentinal tubules was observed by FE-SEM. The results are shown in Table 2.

<Table 2>

First, referring to FIGS. 1 to 7, the larger the area of dark circles (clear zones) formed in the periphery of the fluorochemical coating composition located at the center of the culture medium, the better the antibacterial activity. It can be seen that Example 1 is superior.

 It can be seen from the results of Table 2 that the examples according to the present invention have very excellent properties in the results of antibacterial evaluation as compared with Comparative Example 1. From these results, The antimicrobial activity against Streptococcus mutans is much higher than that of the composition, and it is found that there is an effect of significantly reducing the possibility of dental caries.

In addition, with reference to Table 2 above, when the total fluorine content of Examples 1 to 6 and Comparative Example 1, the fluorine release behavior after 4 hours, and the test result of ivory sealability were compared, the experimental results had similar values As a result, it can be seen that, in the case of the fluoride coating composition according to the present invention, the general action mechanism and properties of the fluoride coating composition are not deteriorated even when natural extracts are included.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it will be understood by those of ordinary skill in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims. will be.

Claims (15)

As a fluorine coating agent composition comprising a resin, a solvent and a fluorine compound,
Wherein the fluoride coating composition further comprises a natural extract exhibiting antibacterial action against noxious bacteria in the oral cavity. 2. The fluoride coating composition according to claim 1, wherein the natural extract is a mixture of Thuja orientalis L. extract, Sparganium stoloniferum extract, or a combination of a Cabbage tree extract and a Ginseng extract. [3] The fluoride coating composition according to claim 2, wherein the content of the natural extract is 0.01 to 1% by weight based on the total weight of the fluorochemical coating composition. The fluoride coating composition according to claim 3, wherein the content of the natural extract is 0.1 to 0.5% by weight based on the total weight of the fluorochemical coating composition. [3] The fluoride coating composition according to claim 2, wherein the natural extract is a mixture of a Cabbage tree extract and a Black ginseng extract, and the mixing ratio of the Cabbage tree extract to the Black ginseng extract is 1 to 99: 1 to 99. [3] The fluoride coating composition according to claim 2, wherein the bark extract is selected from the group consisting of leaves, fruits, and stem of a perennial plant, and the bark extract is concentrated by heating in a solvent. 3. The fluoride coating composition according to claim 2, wherein the black ginseng extract is concentrated by heating the black ginseng outpost in a solvent. The fluoride coating composition according to claim 1, wherein the harmful bacterium is Streptococcus mutans . The fluoride coating composition according to claim 1, wherein the fluoride coating composition further comprises one or two or more additives selected from the group consisting of an emulsifier, an adhesive, a thickener, a sweetener, and a perfume. The method of claim 1, wherein the resin is gum rosin or a woodrod resin,
Natural rosin, Dehydrogenated Rosin, Ester of Hydrogenated Rosin, Fully Hydrogenated Rosin, Partially Hydrogenated Rosin, Dimerized Rosin, , And a hydrocarbon resin (hydrocarbon resin) material,
Based on the total weight of the fluororesin coating composition, 30 to 80% by weight based on the total weight of the fluororeso coating composition. The method of claim 1, wherein the solvent is a volatile solvent,
One or two selected from the group consisting of ethanol, isopropyl alcohol, acetone, benzene, cyclohexane, toluene, n-pentane, n-hexane, n-heptane, n-octane, ethyl acetate, methyl acetate, Or more,
Based on the total weight of the fluororesin coating composition, 10 to 60% by weight based on the total weight of the fluororeso coating composition. The method of claim 1 wherein the fluoride compound is sodium fluoride (NaF), one fluorine-sodium phosphate (Na ₂ PFO _3), fluorinated tin (SnF _2), trifluoride bismuth (BiF _3), fluoride, zinc (ZnF _2), fluoride potassium (KF), calcium fluoride (CaF _2), tetrafluoride zirconium (ZrF _4), six bulhwagyusan (H ₂ SiF _6), and one or two or more selected from the group which consists of six bulhwagyusan sodium (Na ₂ SiF ₆₎ and ,
Is 1 to 10% by weight based on the total weight of the fluororeso coating composition. A natural extract of Thuja orientalis L. extract, Sparganium stoloniferum extract, or a mixture of Quercus acutissima extract and Black ginseng extract, which shows antimicrobial activity against harmful bacteria in the mouth. 14. The natural extract according to claim 13, wherein the natural extract is a mixture of a Cabbage tree extract and a Black ginseng extract, and a mixing ratio of the Cabbage tree extract to the Black ginseng extract is 1 to 99: 1 to 99. 14. The natural extract according to claim 13, wherein the harmful bacterium is Streptococcus mutans .

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