KR20140137759A - A composition comprising extracts or brown rice of Nunkeunhukchal (black sticky rice with giant embryo) for the prevention or treatment of macular degeneration - Google Patents

Abstract

The present invention relates to a composition including black sticky rice with giant embryo (Nunkeunhukchal) and extracts of the same as an effective component for preventing or treating macular degeneration, and to a food composition with enhanced lutein. The extract in the pharmaceutical composition for preventing or treating macular degeneration of the present invention is obtained by extracting black sticky rice with giant embryo with a solvent selected from a group composed of water, alcohol having one to six carbon, hexane, and a mixed solvent of the same.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing or treating macular degeneration including brown rice or an extract thereof, a composition for preventing or treating macular degeneration,

The present invention relates to a composition for preventing or treating macular degeneration and a food composition enriched with lutein, which comprises an extract of Macrogolium giant macrolide and an extract thereof as an active ingredient.

Macula lutea is a macular degeneration of the macula, which is caused by various causes of degeneration of the macula, resulting in visual impairment. do. Such macular degeneration is one of the three causes of blindness, along with glaucoma and diabetic retinopathy. The biggest cause of macular degeneration is age, and it is known to be caused by family history, race, smoking, etc. When the macula is damaged, it loses its ability to recognize details such as small prints, facial features or small objects in the eyes . These macular degeneration are of two types: non-exudative (dry) macular degeneration and exudative (wet) macular degeneration, and 90% of people with macular degeneration have symptoms of dry form. In dry macular degeneration, waste products form a yellow precipitate called drusen, which can accumulate in the submacular tissue. The presence of drusen interferes with blood flow to the retina, particularly the macula, and as blood flow decreases, it reduces the supply of nutrients to the macula, stopping or atrophy the efficient action of the photosensitized cells. In the case of mild macular degeneration, new weak blood vessels may grow in or under the retina, causing liquid and blood to leak into the space below the macula. Hatching macular degeneration is sometimes described as choroidal neovascularization, where the choroid is the area under the retina and the angiogenesis is the new blood vessel growth in the tissue, as can be inferred from the name choroidal neovascularization, And blood vessels start to grow. This type of macular degeneration is considered to be a good disease for the elderly, but recently it has been known that the 4th and 50th patients are rapidly increasing. The major cause of the decrease in the age of onset of macular degeneration is the westernization of dietary habits such as increase of fat intake.

Lutein is a naturally occurring carotenoid that does not have vitamin A activity but is naturally present in large amounts in greenish-yellow vegetables. Lutein, which is one of the most abundant carotenoids in food and human blood, is known to play a role in protecting the plant from ultraviolet rays and antioxidative effect in the plant body. It is known to humans as a main component of the macula and lens of the eye, It is known to play an important role in promoting health and vision. According to the US Department of Agriculture, Americans currently have an average daily lutein intake of about 1.7 mg and a European population of about 2.2 mg, which is a risk for eye diseases such as cataracts and age-related macular degeneration (AMD) , And recently it has been reported that the addition of lutein to dietary supplements and certain food and beverage ingredients increases the level of lutein intake in the US and Europe to a more effective level . However, no food has been reported to analyze lutein in rice and to prevent or ameliorate macular degeneration using rice.

Accordingly, the inventors of the present invention have made efforts to elucidate the rice which can be used for prevention or improvement of macular degeneration by having a high content of lutein, and as a result, it has been confirmed that the macrophyllous giant embryo and its extract contain a large amount of lutein And that the composition comprising the same can be usefully used in the field of prevention, improvement or treatment of macular degeneration. The present invention has been completed based on this finding.

It is an object of the present invention to provide a pharmaceutical composition for the prevention or treatment of macular degeneration, which comprises, as an active ingredient, an extract of Macrogonospora japonica.

It is another object of the present invention to provide a method for treating macular degeneration comprising the step of administering the Macrogromax extract to a suspected macular degeneration subject.

It is still another object of the present invention to provide a food composition for preventing or ameliorating macular degeneration, which comprises an extract of a macrophage macrobiote as an active ingredient.

It is still another object of the present invention to provide a food composition for preventing or ameliorating macular degeneration, which comprises, as an active ingredient, a macroglobin macroalbuminuria.

It is still another object of the present invention to provide a food composition enriched with lutein, which comprises, as an active ingredient, a glaucoma macromeroid.

It is still another object of the present invention to provide a method for extracting lutein from the above-mentioned giant-ray biomass.

As one aspect for achieving the above object, the present invention provides a pharmaceutical composition for preventing or treating macular degeneration, comprising an extract of Macrogonospora gigantis (a black-and-white extract) as an active ingredient.

In the present invention, the term "giant opium giant embryo" refers to black rice having a black waxy giant embryo. The micrograph is characterized by being a giant embryo that is both black and black. For example, the micrograph of a giant embryo developed by breeding of a conventional black rice and a giant bacillus (YR23517Acp79) And the like. Herein, it means that the amylose is composed of 2 to 10% of amylose and 90 to 98% of amylopectin. The giant embryo is a variant of mutant breeding which is 3 to 5 times larger than that of the conventional rice varieties, Rice, which is known to be concentrated more than 80%, is 3 to 5 times larger than common brown rice, meaning that rice has a very rich variety of nutrients.

In the present invention, it was confirmed for the first time that a large amount of lutein is contained in the giant-ray-giant macrobenthic bloom, and it was confirmed that the giant-bite giant macrobenthos containing lutein and its extract can be useful for prevention, improvement or treatment of macular degeneration. Accordingly, in the present invention, the above-mentioned giant-ray-giant-ray-bombardment rice is a rice containing a large amount of lutein, and preferably, it is not limited thereto, but is not limited thereto. The method of breeding is disclosed in Korean Patent No. 10-1201436.

In addition, the giant-ray-giant embryo may be a giant-goblet giant embryo or a goblet giant embryo, preferably a goblet giant embryo, but is not limited thereto.

The term "brown rice " in the present invention means rice in which harvested rice is dried and thawed, and then rice husked with a rubber roller. For the purpose of the present invention, the brown rice refers to rice which has been dried and thawed and then the rice husk has been stripped, but the present invention is not limited thereto.

In the present invention, the term "an extract of a macrophage macrobiite" means an extract obtained by extracting a macrophage macrobiite. The above-mentioned extract of the macrophyllotaxis may be prepared by pulverizing rice, rice or roasted macroglobulin giant embryos and then pulverizing the pulverized product with water, an alcohol having 1 to 6 carbon atoms, preferably methanol, ethanol or butanol, hexane or a mixed solvent thereof The extract may be obtained by extraction with an alcohol having 1 to 6 carbon atoms, more preferably ethanol, even more preferably 70 to 100% ethanol, but is not limited thereto.

The extract may be an extract extracted using an extraction method such as hot water extraction, cold extraction, reflux cooling extraction, or ultrasonic extraction. The extract may be filtered under reduced pressure, the filtrate may be concentrated under reduced pressure, The present invention is not limited to this, and it may be a dried product obtained by drying an extract, a diluted solution or concentrate of an extract, or an extract, or a dried product obtained by drying It includes both controlled or purified products.

Since the macrophyllous macrophyllum extract contains lutein, it can be useful for preventing and treating macular degeneration.

As used herein, the term "lutein" refers to carotenoids that accumulate in the macula, the center of the retina, and are yellow in color. The lutein is mainly located in the macula of the eye and performs antioxidative action to prevent macular degeneration. It is known that lutein is not produced in the body and disappears in the maculae with aging.

The term "macula or macrular lutea " in the present invention refers to a region depressed by about one papillary diameter (about 1.5 mm) in the center of the retina, which is a thin and transparent nerve tissue covering the inside of the eyeball. It refers to the part of the cornea of the eye where the light enters vertically into the center of the lens. In the macula, many photoreceptors are present and account for most of the visual acuity. However, as the aging progresses, the density of the lutein in the macula becomes lowered, and as the action of lutein decreases, it causes retinal tissue damage such as macular degeneration. It has been confirmed in an animal test and a test tube test that lutein can be supplemented to increase the density of the macular pigment when the lutein is supplemented in the form of a nutrient or the like.

The term "macular degeneration" in the present invention means a disease in which a change occurs in the macular part located in the central part of the retina, resulting in visual impairment. Since macula is responsible for central vision, degeneration may cause visual loss, central scarring, and diverticulosis (symptoms that appear to be distorted), but it may not significantly affect visual acuity if it is non-exudative. For the purpose of the present invention, the above-mentioned macular degeneration is not limited to diseases which can be prevented, ameliorated or treated with a macrophage giant embryo or an extract thereof containing lutein.

In the present invention, the term "prevention" means any action that inhibits or delays the onset of macular degeneration by administration of the composition, and "treatment" means that administration of the composition improves or alleviates symptoms associated with macular degeneration It means all acts.

The pharmaceutical composition comprising the extract of the present invention may further comprise an appropriate carrier, an adduct or a diluent conventionally used in the production of a pharmaceutical composition.

The pharmaceutical composition may be in the form of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, lyophilized preparations and suppositories May have one formulation, and may be various forms of oral or parenteral administration. In the case of formulation, a diluent or excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, or a surfactant is usually used. Solid formulations for oral administration include tablets, pills, powders, granules, capsules, and the like, which may contain one or more excipients such as starch, calcium carbonate, sucrose or lactose lactose, gelatin and the like. In addition to simple excipients, lubricants such as magnesium stearate, talc, and the like are also used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. Formulations for parenteral administration include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, and suppositories. Examples of the non-aqueous solvent and the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.

The composition of the present invention may be administered in a pharmaceutically effective amount.

The term "pharmaceutically effective amount" as used herein means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and an effective dose level will vary depending on the species and severity, age, sex, The activity of the drug, the sensitivity to the drug, the time of administration, the route of administration and the rate of release, the duration of the treatment, factors including co-administered drugs, and other factors well known in the medical arts. The composition of the present invention may be administered as an individual therapeutic agent or in combination with other therapeutic agents, and may be administered sequentially or simultaneously with conventional therapeutic agents. And can be administered singly or multiply. It is important to take into account all of the above factors and to administer the amount in which the maximum effect can be obtained in a minimal amount without adverse effect, and can be easily determined by those skilled in the art. The preferred dosage of the composition of the present invention varies depending on the condition and the weight of the patient, the degree of disease, the type of drug, the administration route and the period of time, and the administration may be performed once a day or divided into several times. The composition may be administered to various mammals such as rats, livestock, humans, and the like in a variety of routes. The mode of administration is not limited as long as it is a conventional method in the art. For example, oral, rectal or intravenous, Subcutaneous, intra-uterine dural or intracerebral injection.

In one embodiment of the present invention, it was confirmed that the extract of the black giant giant embryo was produced (Production Examples 1 and 2), and that the extract of the giant-bite giant fibroblast had a higher content of lutein than that of the Japanese and the health interest (Tables 2 to 4 and One). Therefore, the extract of the present invention containing the high content of Lutein can be useful for preventing or treating macular degeneration.

In another aspect, the present invention provides a method for treating macular degeneration comprising the step of administering the above-mentioned macrophage macrophage extract to a subject having macular degeneration.

The above-described giant-ray giant-cell line, its extract, macular degeneration and treatment are as described above.

Specifically, the method of treatment of the present invention comprises administering said pharmaceutical composition in a pharmaceutically effective amount to a subject having macular degeneration. The term refers to whole mammals including dogs, cows, horses, rabbits, mice, rats, chickens or humans, but the mammal of the present invention is not limited by these examples. The pharmaceutical compositions may be administered by non-oral, subcutaneous, intraperitoneal, intrapulmonary, and intranasal routes and may be administered by a suitable method, including localized administration, if necessary, for localized treatment. The preferred dosage of the pharmaceutical composition of the present invention varies depending on the condition and body weight of the individual, the degree of disease, the type of drug, the route of administration and the period of time, but can be appropriately selected by those skilled in the art.

In another aspect, the present invention provides a food composition for the prevention or amelioration of macular degeneration, which comprises, as an active ingredient, an extract of a macrophage macrobiotech.

The above-mentioned macrogravity giant embryonic stem, extract thereof, and macular degeneration are as described above.

Specifically, the extract of the present invention can be added to a food composition for the purpose of preventing or improving macular degeneration. When the extract of the present invention is used as a food additive, the extract or its fractions can be used as it is or can be used together with other food or ingredients, and can be suitably used according to a conventional method. The amount of the active ingredient to be mixed can be appropriately determined depending on the purpose of use.

The kind of the food of the present invention is not particularly limited. Examples of the foods to which the extract of the present invention can be added include dairy products including rice grains, retort brown rice, meat, sausage, bread, chocolates, candies, snacks, confectionery, pizza, ramen noodles, other noodles, gums, , Various soups, beverages, tea, drinks, alcoholic beverages, and vitamin complexes, and may include foods in the conventional sense and used as feed for animals.

In addition to the above, the food composition of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloid thickeners, pH adjusters, stabilizers, preservatives, glycerin, , A carbonating agent used in a carbonated drink, and the like. It may also contain flesh for the production of natural fruit juices, fruit juice drinks and vegetable drinks. The food may also be prepared in the form of tablets, granules, powders, capsules, solutions in liquid form, and the like according to known production methods. There are no particular restrictions on other components other than those containing the extract of the present invention as an active ingredient, and may include various conventional flavors or natural carbohydrates as additional ingredients.

In another aspect, the present invention provides a food composition for the prevention or amelioration of macular degeneration, which comprises, as an active ingredient, a macrophage macrobiotic rice.

The brown rice, macular degeneration and food composition are as described above.

In the present invention, it was confirmed that a large amount of lutein was contained in the giant-ray-giant macrobenthos, especially in the macroglobulin giant embryos, and it was confirmed that the food composition containing the same could be useful for the macular degeneration which can be prevented or improved by lutein.

The composition may include both brown rice alone or processed brown rice. Specifically, the glaucophore macrophyllotrophic bacteria may be contained in a form processed in a state suitable for the shape of the desired food composition. Said goby giant embryonic rice brown rice may be included in the food composition in an appropriate form added to a food composition based on rice such as brown rice, brown rice or roasted brown rice.

In another aspect, the present invention provides a food composition enriched with lutein, which comprises, as an active ingredient, a macrophage macrobiotic rice.

The above-mentioned giant-ray biomass, brown rice, lutein and food composition are as described above.

In the present invention, it has been confirmed that the content of lutein in the giant-ray-giant macrolide of the present invention is excellent, and thus the food composition containing the same has a higher content of lutein than general rice and colored rice, so that it can be particularly useful as a functional food.

In another aspect, the present invention provides a method for producing a microorganism, comprising the steps of: (a) extracting a macroglobulin macroembrobe with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, and a combination thereof; (b) separating and purifying the lutein from the giant-ray extract of brucellar epithelium.

The above-mentioned giant-bore giant embryo, extract and lutein are as described above.

In the present invention, it was confirmed for the first time that the giant-ray-giant embryos, in particular, the giant-ray macromolecular germanium, contain lutein at a high ratio different from that of the Japanese and the Japanese. Therefore, lutein can be obtained by extracting and separating and purifying the macrophage giant embryos.

In the method of the present invention, the step (a) is a step of extracting the giant-ray-macrographic giant embryo with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, and a combination thereof and obtaining a giant- .

The extraction of the giant-ray biomass is performed as described above.

In addition, the gypsum used in the method of the present invention is not limited to the gypsum gypsum, but it may be a gypsum gypsum, and the variety is preferably a gypsum (Milyang 263), but the present invention is not limited thereto.

In the method of the present invention, the step (b) is a step of separating and purifying the lutein from the extract of the macrophage giant fibroblast.

The method for separation and purification of lutein can be carried out through various known methods for separating and purifying compounds, for example, by concentrating the extract of the ginkgo biloba extract and performing column chromatography to obtain a fraction of lutein, The pure separation and purification can be carried out using the following preparative HPLC, but it is not limited thereto.

Since the present invention includes a high amount of lutein, it can be usefully used in fields requiring lutein, such as prevention, improvement and treatment of macular degeneration.

Fig. 1 is a graph showing the results of HPLC analysis of lutein and beta-carotene contents of the giant-bloom giant myoblast.

Hereinafter, the present invention will be described in detail with reference to the following examples. However, the following examples are illustrative of the present invention, and the scope of the present invention is not limited by the following examples.

Manufacturing example  One: Giant biomass  Manufacture of brown rice

Macrogonosporous giant embryonic rice was prepared by cooking rice as a method of enhancing starch of brown rice and brown rice. In general, rice cookers and pressure cookers can be used as a general method of cooking rice. In this test, rice cooked using an electric rice cooker, which is a method used for a standard seasoning test, was used.

Specifically, after 200 g of rice of each variety was washed well, the amount of water was adjusted according to the water content of the rice (based on the rice water content of 14%, the amount of water was 1.2 times). After 20 minutes in water at 20 ° C, water was drained for 10 minutes, and rice was cooked using a conventional electric rice cooker. 10 to 15 minutes after the switch was turned off, the sample was immersed in a drying container for drying, and then dried using hot air drying at 40 ° C and freeze drying.

Manufacturing example  2: Giant biomass  Preparation of extract

In order to measure the content of lutein contained in the extract of black rice giant embryonic rice and rice, it was extracted with a solvent such as ethanol and used as an analytical sample after vacuum concentration.

The pretreatment of black rice, giant embryo, black rice, common rice (Japanese rice) and colored rice (health red rice) used in this experiment was carried out by removing the husk bark and grinding. Material extraction from the crushed sample was performed using 100% water, 40% ethanol or 70% methanol.

Example  One: Giant  Isolation and analysis of lutein and beta-carotene

In order to separate and analyze lutein and beta-carotene from the macrophage giant embryos, the samples obtained in Preparation Examples 1 and 2 were extracted. Specifically, the dried brown rice and rice powder were directly extracted under the extraction conditions shown in Table 1 below. The extracts were extracted with ethanol, and the dried samples were extracted with methanol and extracted under the extraction conditions shown in Table 1, The results of analysis of lutein and beta-carotene of giant embryos are shown in Fig.

As a result, as shown in Fig. 1, it was shown that the macrophage giant myoblast of the present invention contained high lutein.

Lutein and beta-carotene HPLC  Analysis condition Item Contents Extraction condition 100 mg / 5 ml MeOH, 1 hr
Extract with 5ml THF / 4 times and dry HPLC analysis conditions Reverse phase gradient HPLC system
HPLC: Waters 2695 alliance system
Column: C18 guard column (3 탆, 33 x 4.6 mm)
YMC C30 carotenoid column (3 [mu] m, 150 x 3.0 mm)
- Detector: PDA, 450, 340, 292, 330nm
- Solvent A: methanol / tert-butyl methyl ether / water (85: 12: 3, v / v / v, with 1.5%
- Solvent B: methanol / tert-butyl methyl ether / water (8: 90: 2, v / v /
- Gradient procedure: flow rate 0.4 mL / min, 21 min linear gradient to 45% left A, 1 min hold, 11 min linear gradient to 5% left A, 4 min hold, 2 min linear gradient to 100% left

Example  2: Giant biomass  Confirm lutein and beta-carotene content in brown rice

On the basis of the results of Example 1, lutein analysis was carried out by using a black-and-white giant embryo as a comparison group, a general beauty group as a comparative group, and a health red apple as a color pigment. The results are shown in Table 2 below.

Carotenoid (占 퐂 / 100 g) Japan Health Promotion Snowball
( Milyang 263 ) Lutein 5 ± 0.2 6 ± 0.2 244 ± 5 Trans  β- carotene 0 0 25 ± 0.2

As a result, as shown in Table 2, lutein was contained at a level of 5 μg / 100 g in the comparison group, and lutein was contained at 6 μg / In the case of the giant embryonic goblets, the results showed that 244 ± 5 μg / 100 g of lutein was contained. That is, the present invention is a black giant giant embryo of the present invention, which has a lutein content of 40 to 50 times higher than that of a common apple and a coloring matter. The result is that the content of lutein is enhanced. , And extracts thereof, may be usefully used in compositions capable of preventing, ameliorating and treating macular degeneration.

Example  3: Effect of the present invention Giant biomass  Brown rice Crude extract  Confirm yield

The crude extracts were obtained by using water, alcohol (40% ethanol or 70% ethanol) and hexane by using a normal black eye as a comparative group, , And the results are shown in Table 3 below.

Condition(%) Japan
(Extraction amount:%) Health Promotion
(Extraction amount:%) Snowball
(Extraction amount:%) H ₂ O 6.8 3.7 10.4 40% EtOH 2.5 2.5 5.1 70% EtOH 2.3 1.9 4.0 Hexane 2.3 2.6 2.6

As a result, as shown in Table 3, when the crude extract was prepared using water as an extraction solvent, the highest recovery rate of 10.4% was obtained, and 40% ethanol was used for extraction , The recovery rate was 5.1%, which was twice as high as that of sunny and healthy Hongmy. In case of 70% ethanol, the recovery rate was 4.0%, which was twice as high as that of the control group, which was the same as that of the control group. In the case of hexane, which is an organic solvent, it was confirmed that Healthy Hongyu and Snowballs were extracted 2.6% compared with 2.3% of Japan.

Example  4: Effect of the present invention Giant biomass  Brown rice Crude extract  Confirm lutein content

For processing into the food, the content of lutein contained in the crude extract of the present invention was analyzed by extracting with the solvent shown in the following table, and comparing the content of lutein contained in the crude extract, The results are shown in Table 4.

However, EtOH Health Promotion  70% EtOH Snowball  70% EtOH Lutein
(쨉 g / 100 g) 117 ± 6 193 ± 1 4263 ± 69

As a result, as shown in Table 4, in the case of 70% ethanol extract, in the case of Japanese rice and health red rice, 100 μg of lutein and 100 μg of lutein were contained in 100 μg of crude extract, respectively, The results of the present invention show that the crude extract of Giant Macrobrachium japonica contains 4263 g of lutein.

These results indicate that the extract of the present invention can be usefully used in compositions for preventing, ameliorating or treating macular degeneration because it has a higher Lutein content than ordinary rice and colorless rice.

Example  5: Giant biomass A blind eye Fried brown rice  Produce

In the present invention, a method of roasting a brown rice was used to produce a processed product having excellent palatability of the giant-ray-giant macroblock. The temperature was 150 to 170 ° C, and the roasting time was 5 to 20 minutes, The results are shown in Table 5.

kind Expansion temperature (° C) Optimum temperature (℃) Remarks Japan 165-170 167 Burning occurs at temperatures above 170 ℃ Snowball 155-160 157 Burning occurs at temperatures above 160 ℃

As a result, as shown in Table 5, the production conditions of the fried brown rice excellent in palatability were found to be uniform puffing while rotating the brown rice at a temperature of 155 to 160 ° C and a roasting time of 5 to 20 minutes.

Example  6: Depending on processing method Giant  Determination of lutein and beta-carotene content

Changes in the content of lutein and beta-carotene in the goby giant embryo of the present invention under the condition of rice and roasting, which is a general processing form of rice, were analyzed and the results are shown in Table 6 below.

process stir-fry rice kind Japan Health Promotion Snowball Japan Health Promotion Snowball Lutein 0.00 0.00 35.9 ± 1.2 4.3 ± 0.9 5.1 ± 0.2 189.9 ± 1.8 Trans  β- carotene 0.00 0.00 21.9 ± 1.3 0.00 0.00 24.6 ± 0.4

As a result, the fried black eyes of the present invention showed a tendency to decrease in lutein compared with the rice form, but showed a remarkable lutein content as compared with the control fried white rice and roasted healthy white rice. Concretely, the roasted blackcurrants contained about 35.9 μg / 100 g of lutein, and the rice-type blackcurrants had a high lutein content of about 189.9 μg / 100 g. In particular, it exhibits a remarkably high Lutein content, about 38 to 45 times that of Lutein, which is a control group, so that it can be usefully used in the form of a food composition for prevention or amelioration of macular degeneration, in particular rice, cereal rice or retort rice Respectively.

From the above description, it will be understood by those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. In this regard, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive. The scope of the present invention should be construed as being included in the scope of the present invention without departing from the scope of the present invention as defined by the appended claims.

Claims (16)

A pharmaceutical composition for preventing or treating macular degeneration, comprising an extract of Macrobenthic macroglobin as an active ingredient.
2. The composition according to claim 1, wherein the extract is obtained by extracting the macrophage macrophage with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, hexane, and a mixed solvent thereof.
3. The composition of claim 2, wherein the alcohol is selected from the group consisting of methanol, ethanol and butanol.
2. The composition of claim 1, wherein the extract is from a macrophage giant embryonic rice.
2. The composition of claim 1, wherein the giant-ray extract comprises lutein.
The composition according to claim 1, wherein said giant-ray-giant embryonic stem is a blinker (Milyang 263).
A food composition for preventing or ameliorating macular degeneration comprising an extract of a macrophyllotaxis as an active ingredient.
A food composition for preventing or ameliorating macular degeneration comprising, as an active ingredient, an optically anisotropic germanium brown rice.
9. The composition according to claim 8, wherein the giant-ray macromolecular germanium brown rice is in a form selected from the group consisting of brown rice, brown rice and fried brown rice.
9. The composition of claim 8, wherein the macrophage giant embryonic rice contains lutein.
9. The composition according to claim 8, wherein the giant-ray giant-pixel amorphous brown rice is an observer's eye (Milyang No. 263).
The method of claim 8, wherein the composition is selected from the group consisting of cereal rice, retort brown rice, bread, sikhye, meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, Tea, a drink, an alcoholic beverage, and a vitamin complex.
Lutein-enriched food composition comprising as an active ingredient a glucomannan macromolecule brown rice.
14. The composition according to claim 13, wherein the glaucophore giant embryonic rice brown is a glare (Milyang 263).
(a) extracting a macrophage macrophyllum with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, hexane, and combinations thereof; And
(b) separating and purifying the lutein from the extract of the macrophage giant fibroblast.
16. The method according to claim 15, wherein said giant-ray-giant embryonic stem is a giant embryo (Milyang 263).

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