KR20140080955A - Triple Capsule having Immediately Improving Skin Wrinkle and W/O Emulsion Cosmetic Composition For Anti-Wrinkle Comprising It - Google Patents

Abstract

The present invention relates to a triple capsule having an immediate effect on the alleviation of wrinkles and a water-in-oil type cosmetic composition for the alleviation of wrinkles stabilizing the same. More specifically, the present invention relates to a triple capsule having an immediate effect on the alleviation of wrinkles comprising: a core composed of liposomes including bioactive substances; silicone polymers surrounding the core; and a transparent coating layer coating the silicone polymers and composed of polysaccharides derived from Rhodophyta, and relates to a water-in-oil type cosmetic composition for the alleviation of wrinkles stabilizing the triple capsule. According to the present invention, the stability of a formulation of the cosmetic composition is maintained without dissolution of active ingredients, and also, an immediate effect on the alleviation of wrinkles can be obtained by the silicone polymers dissolving due to disintegration of the capsule on the skin caused by hand movements during application of the cosmetic composition to the skin.

Description

TECHNICAL FIELD [0001] The present invention relates to a triple capsule having an immediate wrinkle-improving effect and a cosmetic composition for stabilizing the same,

The present invention relates to a triple capsule which can be stably maintained without leakage of the contents, and a cosmetic composition for waxy wrinkle improvement which can stably disperse the triple capsule to give a visual effect.

Various products have been developed and marketed by various manufacturers so that users can select and use them according to their skin type and preference of use. Thus, in order to meet the needs of various consumers, it is necessary to develop a distinctive formulation that is noticeable.

There have been various developments of visual capsules using polysaccharides derived from red algae such as agar as a capsule membrane.

For example, Korean Patent Registration No. 10-0342357 discloses a composition comprising 1.5 to 3.0% by weight of carageenans, 0.5 to 1.5% by weight of algin, 0.1 to 0.2% by weight of agar, an inorganic filler of an alkaline earth metal silicate 0.05 To 0.2% by weight, and deionized water as the balance, encapsulating and coating a cosmetic composition of W / O or W / S formulation containing make-up base cream or foundation cream, or encapsulating vitamin C or retinol And then encapsulating the physiologically active substances contained therein into a form of W / O or W / S, followed by coating.

In addition, Korean Patent Registration No. 10-0814034 discloses a method of forming a primary capsule by using the physical properties of agar and carrageenan and forming a secondary capsule by using sodium alginate. As a result, swelling by water, which is a disadvantage of agar and carrageenan The present invention proposes a stabilized capsule which does not change when applied to skin lotions containing a large amount of polyol in addition to cosmetics which are conventionally used without being affected by pH,

Generally, in order to apply capsules to cosmetics, it is necessary to keep the shape stable in the state applied to the product, and to be easily and softly disintegrated by shear stress at the time of use, and disappear without any trace to the skin, and even when the capsule shape or size is stored for a long time It should be kept constant.

However, when a polysaccharide derived from red algae such as agar is used as a capsule membrane, swelling of the polysaccharide may change the shape of the capsule, and the contents may be eluted. In order to prevent such problems, when the content of agar is increased, the stability of the capsule is high. However, since the strength of the capsule is high, there is inconvenience that the capsule is broken by using a large physical pressure during use and the penetration of the capsule residues is delayed. there was.

Accordingly, it is required to develop a product which can stably maintain the capsule structure, including a function capable of visually differentiating and supporting an effective ingredient in order to meet various consumer demands.

KR 10-0342357 B1 KR 10-0814034 B1

Accordingly, the inventors of the present invention have conducted intensive studies to ensure the safety of being able to be stably maintained without visual differentiation and dissolution of the contents in using the transparent polysaccharide derived from red algae as a capsule membrane. As a result, When the capsule is encapsulated with a polysaccharide derived from red algae, the stability of the formulation is maintained without elution of the active ingredient, and the silicone polymer eluted by the collapse of the capsules on the skin due to the skin during application of the skin, And the present invention has been completed on the basis thereof.

It is an object of the present invention to provide a triple capsule having improved stability of formulation together with visual differentiation by using polysaccharide derived from red algae as a capsule membrane.

Another object of the present invention is to provide a cosmetic composition for improving wrinkles which is stabilized so as to maintain the capsule structure without elution of the contents carried on the triple capsule.

In order to achieve the above object,

A core comprising a liposome encapsulating a physiologically active substance;

A silicone polymer surrounding the core; And

The silicone polymer was coated, and a transparent coating layer composed of polysaccharides derived from red algae

The present invention provides a triple capsule having an immediate wrinkle-reducing effect.

The present invention also provides a water-in-oil wrinkle-improving cosmetic composition containing the triple capsule.

According to the present invention, the stability of the formulation can be maintained without elution of the active ingredient, and the silicone polymer eluted by the collapse of the capsules on the skin due to the skin during application of the skin can be immediately obtained with the effect of improving wrinkles.

1 is a schematic diagram showing a triple capsule according to the present invention.
2 is a photograph of the triple capsule prepared in Example 1 of the present invention.
FIG. 3 is a graph showing a result of measurement of a wrinkle depth reduction rate in order to confirm an immediate wrinkle-reducing effect of the triple capsule according to the present invention.
FIG. 4 is a photograph of an image of the surface of the skin before and after application to confirm an immediate wrinkle-reducing effect of the triple capsule according to the present invention.

Hereinafter, the present invention will be described in more detail.

1 is a schematic diagram showing a triple capsule according to the present invention.

Referring to FIG. 1, a triple capsule includes a core including a liposome encapsulating a physiologically active substance; A silicone polymer surrounding the core; And a transparent coating layer coated with the silicone polymer and composed of polysaccharides derived from red algae.

At this time, the liposome forming the core has an average particle diameter of 50 to 200 nm.

The liposome encapsulated with the active ingredient in the present invention can be prepared by a known method. For example, it is prepared by a mixture comprising an active ingredient, a polyol, an oily ingredient, a surfactant, a phospholipid and water.

The polyol is not particularly limited, and preferable examples thereof include propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, methylpropanediol, isopropylene glycol, pentaerythritol, erythritol, Xylitol, sorbitol, and mixtures thereof.

As the oily component, various oils known in the art may be used, and preferably hydrocarbon oils such as hexadecane and paraffin oil, ester synthetic oil, silicone oil such as dimethicone and cyclomethicone, sunflower But are not limited to, vegetable oils such as corn oil, corn oil, soybean oil, avocado oil, sesame oil and fish oil, ethoxylated alkyl ether oils, propoxylated alkyl ether oils, phytosphingosine, sphingosine and sphinganine The same sphingoid lipids, cervuloside cholesterol, sitosterol cholesteryl sulfate, cetostearyl sulfate, C10-40 fatty alcohols and mixtures thereof.

The surfactant used in the liposome of the present invention may be any surfactant known in the art. For example, in the present invention, an anionic surfactant, a cationic surfactant, a positive surfactant, and a nonionic surfactant can be used as the surfactant, and an anionic surfactant and a nonionic surfactant can be preferably used . Specific examples of anionic surfactants include alkyl acyl glutamates, alkyl phosphates, alkyl lactylates, dialkyl phosphates and trialkyl phosphates. Specific examples of nonionic surfactants include polysorbates, alkoxylated alkyl ethers, alkoxylated alkyl esters, alkylpolyglycosides, polyglyceryl esters and sugar esters.

Both phospholipids are used as the phospholipids, and natural phospholipids (for example, yolk

Lecithin or soy lecithin, sphingomyelin) and synthetic phospholipids (for example, dipalmitoyl phosphatidylcholine or hydrogencontained lecithin), preferably lecithin. In particular, unsaturated lecithin or saturated lecithin derived from natural origin extracted from soybean or egg yolk is preferable. Normally, the amount of phosphatidylcholine is 23 to 95% and the amount of phosphatidylethanolamine is 20% or less in natural derived lecithin.

The water is distilled water, preferably deionized distilled water.

The physiologically active component captured by the liposome may be any component known in the art. For example, a physiologically active ingredient used for the preparation of a cosmetic composition such as a whitening agent, a collagen synthesis promoter, a wrinkle remover, a skin barrier enhancer, an aging inhibitor, or a moisturizer may be used. Acetyltetapeptide is preferably used. Acetyltetrapeptide is a protein formed by the condensation reaction of an acetic acid and four amino acid residues, for example, a protein composed of acetyl-glycine-histidine-lysine-glycine. These proteins are easily penetrated by the acetyl group to the skin's skin layer and promote the synthesis of fibronectin, laminin, elastin and collagen to reinforce the cellular structure of the dermis, thereby improving skin elasticity and wrinkle Excellent effect.

The core is surrounded by a silicone polymer.

At this time, the silicone polymer protects the core carrying the active ingredient from being eluted and gives the color of the triple capsule.

The silicone polymer dissolves when the transparent coating layer on the skin collapses due to skin contact during skin application. When applied to skin, it spreads smoothly with a silky feel. It does not shine after use, gives a transparent feeling, and conceals wrinkles, thereby exhibiting an immediate wrinkle-reducing effect.

The material of such a silicone polymer is not particularly limited in the present invention, and any material can be used as long as it is ordinarily used for cosmetic composition. For example, a polymer having a particle diameter of 1 to 10 mu m may be selected from dimethyl siloxane, dimethicone / vinyl dimethicone cross polymer, vinyl dimethicone / methicyl silsesquioxane cross polymer, dimethicone / phenyl vinyl dimethicone cross polymer, lauryl dimethicone / Vinyl dimethicone crosspolymer, and a combination thereof.

The silicone polymer is coated with a transparent coating layer composed of polysaccharides derived from red algae.

At this time, the polysaccharide derived from red algae can be selected from the group consisting of carrageenan, agar and agarose.

Preferably, the ratio of each composition constituting the triple capsule according to the present invention is 100% by weight

(a) (i) 3 to 7% by weight of a liposome encapsulated with an active ingredient,

(Ii) 5.0 to 30.0% by weight of a moisturizing agent,

(Iii) an aqueous phase containing water as the remainder, and

(b) (i) 15 to 30% by weight of silicone polymer.

(Ii) 1 to 10% by weight of oil,

(c) 5 to 8% by weight of a polysaccharide derived from red algae.

The liposome is contained in an amount of 3 to 7% by weight based on the total weight of the capsules. If the content of the liposome is less than the above range, the effect of the addition is insignificant. If the content of the liposome is more than the above range, the capsule size becomes excessively large and the feeling of use is reduced.

Usable humectants include polyhydric alcohols such as glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, 1,2-pentanediol and isoprene glycol; Amino acid, sodium lactate, and sodium pyrrolidonecarboxylate, and other ingredients such as xyloglucan, corn seed, carrageenan, pectin, mannan, cardan, galactan, deltansulfuric acid, glycocon, keratan sulfate, chondroitin, But are not limited to, tin sulfate, kerato sulfate, chondroitin, mucoitin sulfate, kerato sulfate, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharide, chondroitin A water-soluble polymeric substance which is sulfuric acid; Dimethyl polysiloxane, methylphenyl siloxane; Culture supernatant of lactic acid bacteria and bifidobacteria; And a combination of these.

The content of the moisturizing agent is used in an amount of 5.0 to 30.0% by weight, preferably 5.0 to 20.0% by weight in the whole water-in-oil type emulsion composition. If the content is less than the above range, a sufficient moisturizing effect can not be imparted. On the other hand, if the content exceeds the above range, the content of the other composition is decreased and the effect can not be secured.

Use properly within the range.

The silicone polymer is contained in an amount of 15 to 30% by weight based on the total weight of the capsule. At this time, if the content of the silicone polymer is less than the above range, the wrinkle improving effect and the capsule stability improving effect are insignificant. If the content exceeds the above range, the capsule size becomes too large and the feeling of use is lowered.

The oil is not particularly limited in the present invention, and any oil conventionally used in this field is possible. Typically, hydrocarbon-based oils including polydecene and paraffin oil; Ester-based synthetic oils including cetyl ethylhexanoate, glyceryl trioctanoate, octyldodecyl myristate, isopropyl palmitate, isopropyl myristate and octyl palmitate; Silicone oils including cyclomethicone and dimethicone; Animal oil; Vegetable oils including mango butter, shea butter, copoic acid butter, macadamia seed oil; Ethoxylated alkyl ester oils; cholesterol; Cholesteryl sulfate; Phytosphingosine; Sphingoid lipid; One selected from the group consisting of C10-C40 fatty alcohols such as butyl alcohol, behenyl alcohol, cetostearyl alcohol, cetyl alcohol and stearyl alcohol, caprylic / capric triglyceride, ceramide, and mixtures thereof .

If the amount of the oil is less than the above range, the silicone polymer can not be effectively dispersed. On the contrary, if the content exceeds the above range, the stability of the capsule is lowered. Therefore, Use properly within the range.

The red algae-derived polysaccharide constituting the transparent coating layer in the triple capsule is preferably used in an amount of 5 to 8% by weight. If the amount is less than the above range, there is a problem that capsule formation is difficult, and even if it is formed, the stability is lowered and the contents are eluted through the capsule shell. On the contrary, when the above-mentioned range is exceeded, the feeling of use is lowered, and skin irritation as well as delicate infiltration of broken capsule residues is delayed, which is a problem.

In the present invention, the triple capsule is stabilized with a water-in-oil type (w / o) emulsified composition.

According to Experimental Example 2 of the present invention, when the triple capsules were formulated with a water-in-oil type cosmetic composition, the stability of the formulation was better than that of a water-in-water type composition or a viscous gel composition.

The composition of the water-in-oil type cosmetic composition is composed of an upper part and an upper part, and the composition of the upper part and the upper part is not limited to the present invention and may vary depending on each formulation to be manufactured.

The formulations of each formulation may contain various bases and additives necessary and appropriate for the formulation of the formulation, and conventional additives may be used to the extent that the effect is not impaired.

Preferably, the water-in-oil type cosmetic composition according to the present invention comprises an oil phase part comprising 5.0 to 50.0% by weight of an oil, 3 to 20% by weight of a triple capsule and 0.1 to 10% by weight of a stabilizer so as to satisfy 100% 1 to 20% by weight of a polyol, and water as a remainder.

At this time, if the content of the triple capsules is less than the above range, it is difficult to ensure visual differentiation. On the other hand, if the content is above the range, the feeling of use and the stability of the formulation deteriorate.

The method for preparing the water-in-oil type cosmetic composition is not particularly limited in the present invention, and it follows the known method for producing the composition. For example, it is possible to prepare the mixture by adding each composition to the mixer and uniformly mixing them. The mixing can be performed by applying heat as required, and a mixer such as a homogenizer is used for uniform mixing.

At this time, the water phase is heated to 50 to 80 ° C, preferably 65 to 75 ° C, and if necessary, the mixture is stirred for 3 to 10 minutes at a speed of 2000 to 4000 rpm, preferably 3000 rpm, using a homomixer.

Examples of the oil used herein include mango butter oil, shea butter oil, cocoa bean seed oil, macadamia nut oil, olive oil, midoform seed oil, refined grape seed oil, rosehip oil, sapphire oil, peach seed oil, Vegetable oils such as oils; Dicaprylyl carbonate, squalane, neopentyl glycol deptanoate, tocopheryl acetate, trioctanoin, C12-15 alkyl ethyl hexanoate, octyldodecyl myristate, tricaprylyl, octyldodecylstearoyl Stearate, bis-hydroxyethoxypropyl dimethicone, caprylic, capric triglyceride, isotridecylisononanoate, polyglyceryl-2 triisostearate, diisostearyl malate, dipentaerythritol, But are not limited to, synthetic esters such as isopropyl myristate, isopropyl myristate, cetyl ethyl hexanoate, cetyl octanoate, ozokerite, glyceryl trioctanoate, octyldodecyl myristate, isopropyl palmitate, isopropyl myristate, oil; Silicone oils such as phenyl trimethicone, cyclomethicone, dimethicone, and decamethyl cyclopentasiloxane; Hydrogenated oils, including hydrogenated, hydrogenated PVC-60 castor oil, hydrogenated polyisobutene, hydrogenated polydecene; Or a combination of these may be further used.

The oil comprises 5 to 50.0% by weight of the total composition. If the content is less than or more than the above range, the stability of the water-in-oil emulsion composition deteriorates and it is difficult to produce various products.

Stabilizers include hydrocarbons; And a fatty acid, a silicone polymer stabilizer selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, and mixtures thereof. Examples of the silicone polymer include biphase 15 / methylethyldimethylsilane, dimethicone / dimethicone phage-10/15, dimethicone / polyglycerin-3, dimethicone / dimethicone, dimethicone / dimethicone vinyl dimethicone , Cyclomethicone / dimethicone, cyclomethicone / dimethicone, cyclomethicone / trimethylsiloxysilicate, cyclopentasilonic acid / dimethicone, cyclopentasilonic acid / phage-12 dimethicone, cyclopentasilonic acid / At least one selected from the group consisting of cetearyl dimethicone / vinyl dimethicone, cyclopentasilonic acid / dimethicone / vinyl dimethicone, dimethicone / vinyl dimethicone cross polymer.

The stabilizer comprises from 0.1 to 10.0% by weight of the total composition. If the content is less than or more than the above range, the stability of the water-in-oil emulsion composition deteriorates and it is difficult to produce various products.

Water is distilled water, preferably deionized distilled water.

Usable humectants include polyhydric alcohols such as glycerin, erythritol, xylitol, maltitol glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, 1,2-pentanediol and isoprene glycol; Amino acid, sodium lactate, and sodium pyrrolidonecarboxylate, and other ingredients such as xyloglucan, corn seed, carrageenan, pectin, mannan, cardan, galactan, deltansulfuric acid, glycocon, keratan sulfate, chondroitin, But are not limited to, tin sulfate, kerato sulfate, chondroitin, mucoitin sulfate, kerato sulfate, locust bean gum, succinoglucan, calonym acid, hyaluronic acid, heparan sulfate, sodium hyaluronate, collagen, mucopolysaccharide, chondroitin A water-soluble polymeric substance which is sulfuric acid; Dimethyl polysiloxane, methylphenyl siloxane; Culture supernatant of lactic acid bacteria or bifidus bacteria; And a combination of these.

At this time, other ingredients besides the composition can be arbitrarily selected and formulated according to the formulations of the other cosmetics, the purpose of use, and the like.

Examples of the wrinkle improving agent include ascorbyl glucoside, kinetin, auxin, a peptide, an alpha-hydroxy (hydroxypropyl) phosphate, and the like. Acid, etc. may be used. As the whitening agent, arbutin, ascorbic acid, magnesium ascorbyl phosphate, ascorbyl acid-2-glucoside and the like may be used. The effective active ingredient is used in an amount of not more than 5% by weight in the aqueous phase.

In the oily phase, useful licorice, ethyl ascorbyl ether, alpha-bisabolol and the like having a whitening effect as an effective active ingredient can be used. As the active ingredient having a wrinkle-reducing effect, an oil soluble active ingredient such as retinol and derivatives thereof (e.g., retinyl palmitate), adenosine and the like can be used. These active ingredients are used in an amount of 0 to 10.0% by weight, preferably 0.001 to 10.0% by weight, in the whole composition.

In addition, if necessary, auxiliary surfactants, pigment powders, pigments, sunscreen agents, neutralizing agents, pH adjusting agents, preservatives, bactericides, oxidative stabilizers, organic solvents, thickeners, softening agents, antioxidants, free radical destruction A preservative, an antipruritic agent, a substance P antagonist, a filler, a polymer, a propellant, a basicizing or acidifying agent, or a preservative, an antioxidant, a stabilizer, an emollient, a silicone, an alpha hydroxy acid, a defoamer, a vitamin, Colorants, and the like. The selection of the additive can be made by a person having ordinary skill in the art, and the content thereof is also used within a usual range. Preferably, the content of such additives should not exceed 15% by weight in the total cosmetic composition.

When the formulation is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or fatty acid esters of sorbitan.

The preservative may be selected from the group consisting of methylparaben, propylparaben, butylparaben, ethylparaben, phenoxyethanol, and the like. The colorant may be PMMA (polymethylmethacrylate), silica, nylon, polyurethane, Iron, iron oxide, pearl, synthetic mica, mica, talc, cerasite and boron nitride may be mixed and used.

In addition, as an ultraviolet screening agent, both an organic ultraviolet screening agent and an inorganic ultraviolet screening agent can be used.

Examples of the organic sunscreen agents include octylmethoxycinnamate, octyl salicylate, octocrylene, butylmethoxydibenzoylmethane, oxybenzone, octyltriazone, menthyl anthranilate, 3,4-methyl benzylidene kempfer, isoamyl P-methoxycinnamate, bisethylhexyloxyphenol methoxyphenyltriazine, methylenebisbenzotriazolyltetramethylbutylphenol and the like can be used. As the inorganic ultraviolet blocking agent, titanium dioxide having an average particle size of 5 to 100 nm, Zinc oxide having an average particle size of 5 to 300 nm, iron oxide having an average particle size of 5 to 300 nm, or the like can be used.

The water-in-oil type cosmetic composition of the present invention can be used as a cosmetic composition for cosmetics such as softening longevity, convergent lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, gel, powder, Creams, body oils, and body essences.

Hereinafter, preferred embodiments and experimental examples are provided to facilitate understanding of the present invention. However, the following examples are provided to further understand the present invention, and the present invention is not limited by the examples.

Example 1: Production of agar capsule

The ingredients shown in Table 1 were added to a mixer, uniformly mixed using a homogenizer, and a liposome composition was prepared at 1000 atm using a high-pressure microfluidizer (U.S. Patent 4533254).

ingredient Content (% by weight) Purified water 44 glycerin 30 Lecithin 5 Caprylic / capric triglyceride 10 Dimethicone 10 Acetyltetrapeptide-1 One

The liposomes prepared above were added to the mixer in the amounts shown in Table 2 below and homogeneously mixed using a homogenizer to prepare double capsules formed of silicone polymers.

ingredient Content (% by weight) Purified water 35 glycerin 15 Butylene glycol 5 Dimethicone / Vinyl Dimethicone Crosspolymer 30 Cyclomethicone 10 Liposome composition 5

Using the double capsules prepared above, spherical drops were formed with the vibration cut system of the ultrasonic mixing method in the contents shown in the following Table 3, and agar coated to prepare triple capsules. The prepared triple capsules are shown in Fig.

ingredient Content (% by weight) Triple capsule A Triple Capsule B Double Capsule Drop 92 90 Baby 8 10

EXPERIMENTAL EXAMPLE 1 Evaluation of Satisfaction with Usability According to the Content of Aga in Triple Capsules

The cosmetic compositions containing the triple capsules A and B prepared in Example 1 were prepared with the compositions shown in Table 4 below.

ingredient Content (% by weight) Formulation Example 1 Comparative Formulation Example 1 Purified water to 100 to 100 glycerin 20 20 Clofenine Suitable amount Suitable amount Magnesium sulfate 0.5 0.5 Piggy / Pefji - 19/19 Dimethicone 3 3 Cyclopentasiloxane 10 10 Dimethicone crosspolymer 5 5 Triple capsule A 10 - Triple Capsule B - 10 Phenoxyethanol Suitable amount Suitable amount

Evaluation of usability (putting ability) of Formulation Example 1 and Comparative Formulation Example 1 prepared above was carried out, and detailed evaluation methods and results are as follows.

Twenty women aged 25 to 50 years of age were evaluated for usability by applying a cosmetic composition twice a day to the skin of the eyes and expressing satisfaction with the spreadability. The average value was expressed as a result. The satisfaction criteria are shown in Table 5 below, and the results are shown in Table 6.

Very good. 5 points Good. 4 points is average 3 points It does not work well. 2 points I do not play at all. 1 point

division Usability satisfaction Formulation Example 1 4.4 Comparative Formulation Example 1 3.5

As shown in Table 6, in Comparative Example 1 in which the content of agar in the triple capsules was 10% by weight, compared with that of Formulation 1 in which the content of agar was 8% by weight, It was found that the capsule of the capsule was hardly collapsed and the usability was not satisfactory.

Experimental Example 2: Comparison of stability of triple capsules in composition

In order to compare the stability of the prepared triple capsule A in the formulation, the water-in-oil type emulsion composition (Formulation Example 2), the water-in-oil type emulsion composition (Comparative Formulation Example 2) and the viscous gel composition Formulation Example 3) was prepared.

ingredient Content (% by weight) Formulation Example 2 Comparative Formulation Example 2 Comparative Formulation Example 3 Awards Purified water to 100 to 100 to 100 glycerin 20 20 20 Clofenine Suitable amount Suitable amount Suitable amount Magnesium sulfate 0.5 - - Paid FAGE-100 stearate / glyceryl stearate - 3 - Piggy / Pefji - 19/19 Dimethicone 3 - - Cyclopentasiloxane 10 10 - Dimethicone crosspolymer 5 5 - Carbomer - 0.2 0.2 Tromethamine - 0.2 0.2 ethanol - - 3 Piggy-60 Hydrogenated castor oil - - 0.5 Triple capsule A 10 10 10 Phenoxyethanol Suitable amount Suitable amount Suitable amount

[Water-in-oil emulsion composition (Formulation example 2)]

1. The water phase and oil phase were heated to 65 ° C respectively.

2. The water phase was added to the oil phase and homogeneously mixed using a homogenizer.

3. Triple capsules were added and homogeneously mixed using a paddle mixer and then cooled.

[Emulsion composition for underwater type (Comparative Formulation Example 2)]

1. The water phase and the oil phase were heated to 75 DEG C, respectively.

2. The oil phase was added to the water phase and homogeneously mixed using a homogenizer.

3. After the increase, the triple capsules were added and uniformly mixed using a paddle mixer and then cooled.

[Viscous gel composition (Comparative Formulation Example 3)]

1. The water phase and the ethanol phase were uniformly dissolved respectively.

2. The ethanol phase was added to the water phase and mixed uniformly.

3. After the increase, triple capsules were added and mixed uniformly using a paddle mixer.

The thus prepared composition was stored at 45 캜 for 2 months, and the stability was compared. The results are shown in Table 8.

division Capsule state Immediately after manufacture Formulation Example 2 Spherical good rectangle Comparative Formulation Example 2 Dissolving in atypical form rectangle Comparative Formulation Example 3 Dissolving in atypical form rectangle

In the case of Formulation 2 formulated with a water-in-oil type emulsion composition, it is possible to visually differentiate capsules by controlling the refractive index while maintaining the shape of the triple capsules. On the other hand, in Comparative Formulation Example 1 which was formulated with an emulsion composition for an underwater type, the emulsion composition was formulated into a milky white color, and the capsule was hardly expressed visually, and the shape of the capsule was not maintained at a high temperature. Also, in Comparative Formulation Example 2, which was formulated with a viscous gel composition, the capsule was visually expressed with a colorless transparent viscous gel, but it was difficult to maintain the capsular form at high temperature.

Experimental Example 3: Measurement of immediate wrinkle effect

The composition was prepared according to the composition of Table 9 below in order to measure the immediate wrinkle effect on the triple capsules. The detailed evaluation methods and results are as follows.

The general agar capsule is prepared by preparing a liposome composition according to the composition of Table 1 of Example 1 and forming a spherical drop by a vibration cut system of an ultrasonic mixing method to coat the agar. . ≪ / RTI > At this time, the ratio of the material inside the agar capsule to that of the triple capsule A was the same.

(Request: I have modified the triple capsule A with the same baby content.

20 women aged 30 to 60 years were applied to the skin of the eyes once after washing to measure the depth of the wrinkles. The wrinkle depth measurement equipment was Derma Top-Blu (Germany) from Breuckmann, and the camera attached to the measuring equipment was focused on the eyelid skin, then the image was taken and the depth of the wrinkle was measured by the image analyzer software. And the measurement position was designated to measure the wrinkle depth reduction rate after application of the cosmetic composition. At this time, the initial wrinkle depth was set to '0', and the wrinkle depth reduction rate was measured to determine the evaluation criteria, and the average value of the measurement object was calculated and then rounded to one decimal place or more. The results are shown in FIG. 3 and FIG.

ingredient Content (% by weight) Formulation Example 3 Comparative Formulation Example 4 Purified water to 100 to 100 glycerin 20 20 Clofenine Suitable amount Suitable amount Magnesium sulfate 0.5 0.5 Piggy / Pefji - 19/19 Dimethicone 3 3 Cyclopentasiloxane 10 10 Dimethicone crosspolymer 5 5 Triple capsule A 10 - Common agar capsule - 10 Phenoxyethanol Suitable amount Suitable amount

3 and 4, it can be seen that Formulation Example 3 comprising a triple capsule according to the present invention has a wrinkle depth reduction ratio that is higher than Comparative Formulation Example 4 containing a general agar capsule, .

Claims (7)

A core comprising a liposome encapsulating a physiologically active substance;
A silicone polymer surrounding the core; And
The silicone polymer was coated, and a transparent coating layer composed of polysaccharides derived from red algae
Wherein the triple capsule has an immediate wrinkle-reducing effect. The method of claim 1, wherein the silicon polymer is selected from the group consisting of dimethylsiloxane, dimethicone / vinyl dimethicone crosspolymer, vinyl dimethicone / methicylsyesquioxane cross polymer, dimethicone / phenylvinyl dimethicone crosspolymer, lauryl dimethicone / vinyl Dimethicone crosspolymer, and a combination thereof. The triple capsule according to claim 1, wherein the polysaccharide derived from red algae is one selected from the group consisting of carrageenan, agar, and agarose. 2. The triple capsule according to claim 1, wherein the physiologically active substance is acetyltetapeptide-1. [Claim 3] The triple capsule according to claim 1, wherein the triple capsule has a total composition of 100%
(a) (i) 3 to 7% by weight of a liposome encapsulated with an active ingredient,
(Ii) 5.0 to 30.0% by weight of a moisturizing agent,
(Iii) an aqueous phase containing water as the remainder, and
(b) (i) 15 to 30% by weight of silicone polymer.
(Ii) 1 to 10% by weight of oil,
(c) 5 to 8% by weight of polysaccharides derived from red algae,
≪ / RTI > 7. A cosmetic composition for wrinkle-improving in water, comprising the triple capsule according to claim 1. The cosmetic composition according to claim 6, wherein the triple capsule is contained in an amount of 3 to 20% by weight in the total composition.

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