KR20140077804A - Blood purifying filter and blood purifying apparatus having the same - Google Patents

Abstract

A blood purifying filter of the present invention comprises a plasma separation filter for separating plasma from blood if blood flows into one side thereof; a hemodialysis filter connected with the plasma separation filter and removing toxins and waste in blood; a housing for comparting a plasma floating section outside the plasma separation filter and the hemodialysis filter while providing an installation space for the plasma separation filter and the hemodialysis filer; and a plasma outflux for enabling the plasma passed the hemodialysis filter to be discharged, wherein the housing comprises a container-shape wall; a lower cap coupled with the plasma separation filter in the lower side of the wall; and an upper cap coupled with the hemodialysis filter in the upper side of the wall, and an absorbent provided in the plasma floating section for removing toxins and wastes in the plasma. The blood purifying filter of the present invention integrates a plasma separation process for separating plasma from blood; an absorption process for removing liver toxins and waste from the plasma separated; and a hemodialysis process for removing urotoxins and waste in blood, thereby having advantages of effectively purifying blood of a patient who needs a blood purifying therapy, miniaturizing the entire blood purifying apparatus, improving convenience in installation and use by using one filter, and reducing blood purifying treatment costs.

Description

TECHNICAL FIELD [0001] The present invention relates to a blood purifying filter and a blood purifying apparatus having the same,

The present invention separates blood plasma in a patient's blood using a plasma separation filter and then removes the toxins in the separated plasma using an adsorbent such as activated charcoal or anion exchange resin, To a blood purification filter device configured to perform hemodialysis to remove water-soluble toxins and uremic toxins in the blood of a patient.

Diseases such as decreased liver function, decreased renal function, or multi-organ failure accompanied by systemic inflammatory reactions are accompanied by accumulation of toxins in the body. If liver or kidney transplantation is not done in time, blood purification should be performed to circulate the blood outside the body and remove toxins in the blood by various methods such as dialysis, filtration, or adsorption.

Especially, the liver has a function to metabolize various nutrients in our body, a function to store nutrients necessary for our body, a function to synthesize plasma proteins such as bile and albumin, and various kinds of substances It performs many functions such as decrypting toxins. Therefore, when the liver function is impaired, the substances to be removed through the liver metabolism such as ammonia and bilirubin are accumulated in the body, resulting in lethal complications such as jaundice, hepatic coma, and even multiple organ failure.

Although the liver is known to be capable of self recovery to some degree, even in the case of liver failure due to illness, severe or acute liver failure can not survive until the liver is self-recovering, Since it is often not recovered by itself, the liver is considered the sole therapy. However, if you look at the liver transplant data from the OPTN / SRTR Annual Report released in 2010, it is known that only 30-40% of the patients waiting for transplant are receiving the transplant. This is because the number of donated donations is significantly lower than in patients requiring transplantation. Therefore, for liver failure patients, artificial liver treatment is indispensable to replace liver function until liver transplantation or liver self-healing.

The artificial liver device currently in clinical use is limited to MARV (Molecular Adsorbent Recirculating System) of Cambros and Prometheus of PRESENIUS. MARS combines plasma protein called albumin into dialysate to detect hepatic toxin ), Because of the high cost of these albumin, MARS costs expensive treatment. Prometheus consists of separating plasma from the blood, passing the separated plasma through the ionic resin adsorbent, removing the toxins present in the plasma, and hemodialysis again after plasma separation and adsorption. Thus, the Prometheus device is complex with systems such as a plasma separation filter, two adsorption filters to remove toxins from the plasma, and hemodialysis procedures, which, in turn, require expensive treatment costs as well as MARS.

In order to solve the problems of the conventional artificial liver system, a 'blood purifying device' that integrates plasma separation and adsorption processes in one filter, which is configured to remove toxins in the plasma without using expensive albumin, (Korean Patent No. 1071402) Patent has been registered. However, in the case of the 'blood purifying device' patent, the entire system for artificial liver treatment was simplified compared to the conventional artificial liver device by implementing the plasma separation and the plasma adsorption process in one filter, but the blood filtration or hemodialysis Procedures are required. In patients who require intensive blood purification therapy, such as hepatic insufficiency or multiple organ dysfunction, it is desirable to remove hepatic toxins or protein-bound toxins through adsorption, It is also important to remove uremic toxins or water-soluble toxins that accumulate in the body. Therefore, additional hemodialysis procedures are required.

As described above, since conventional artificial liver devices require a hemodialysis filter, a plasma separation filter, and a plurality of adsorption filters, expensive treatment cost is inevitable and all of these filters are separated The blood or plasma flows in the reverse direction of gravity, and the arrangement space of each filter must be secured. As a result, the size of the system is inevitably enlarged. Also, since each filter must be arranged in a predetermined order, it takes a long time to prepare for installation and treatment.

Korean Patent No. 10-1071402 (September 30, 2011)

Disclosure of Invention Technical Problem [6] The present invention has been proposed in order to solve the above-mentioned problems, and it is an object of the present invention to provide a blood separation method and a blood separation method for separating plasma from blood, an adsorption procedure for removing toxins present in separated plasma, By integrating the dialysis procedure into one filter, it is possible to simplify and miniaturize the entire blood purification apparatus by using one filter, as well as efficiently purifying the blood of a patient in need of blood purification therapy, And an object of the present invention is to provide a blood purification filter that improves convenience.

According to an aspect of the present invention, there is provided a blood purifying filter comprising: a plasma separation filter for separating blood plasma from blood when blood flows into one side; blood for removing toxins and wastes in the blood, A dialysis filter, a space for installing the plasma separation filter and a hemodialysis filter, a housing for partitioning a plasma flow section outside the plasma separation filter and the hemodialysis filter, and a plasma The plasma outlet. The housing includes a tubular wall, a lower cap connected to the plasma separation filter at a lower side of the wall, and an upper cap coupled to the hemodialysis filter at an upper side of the wall.

The lower cap includes a lower cap blood port for blood flow and a lower cap insertion slot for easily coupling with the plasma separation filter. The upper cap includes an upper cap blood port for flowing blood, And an upper cap flow port for dialysate flow. In addition, a connection port connecting the plasma separation filter and the hemodialysis filter is provided so that blood does not leak, and the size and shape of the connection port may be changed to secure the coupling between the hemodialysis filter and the plasma separation filter.

The plasma separation filter includes a plasma separation filter housing having an inner space and a plasma separation membrane accommodated in an inner space of the housing. The inner space of the plasma separation filter housing is divided into a region where blood flows and a region where plasma flows . And a plasma flow hole is provided at one side of the plasma separation filter housing so that separated plasma can flow into the plasma flow section.

Similarly, the hemodialysis filter includes a hemodialysis filter housing having an inner space and a blood dialysis membrane accommodated in an inner space of the housing, and the inner space of the hemodialysis filter housing is divided into a region where blood flows through the blood dialysis membrane, As shown in Fig. At one side of the hemodialysis filter housing, a flow hole is provided for the flow of the dialysis liquid.

,

In the plasma flow section, an adsorbent such as anion exchange resin or activated carbon may be provided to remove toxins and waste materials present in the plasma. The adsorbent included in the blood purifying filter according to the present invention may require blood purification therapy It is preferable that it is changed depending on the patient.

Preferably, the plasma flow hole is provided at a lower side of the plasma separation filter housing so that the plasma introduced through the plasma flow hole can sufficiently be contacted with the adsorbent provided in the plasma flow section before being discharged. It is preferable that the upper cap or the upper cap is provided on the wall which is positioned on the side where the cap is located. And, no adsorbent migrates through the plasma flow hole and the plasma outlet, and various methods can be used for this purpose. For example, the plasma flow hole or the plasma outlet may be made smaller than the size of the adsorbent, or the plasma flow hole or the plasma outlet may be surrounded by a filter having a pore size smaller than that of the adsorbent, Or a separating wall may be provided between the adsorbent and the plasma flow hole and between the adsorbent and the plasma outlet. Likewise, if multiple adsorbents are used, the separating wall may be provided to prevent mixing of adsorbents.

In order to achieve the above object, the blood purifying apparatus according to the present invention is characterized in that when blood in the human body flows into the plasma separation filter through the lower cap blood port by the operation of the blood pump, The blood is separated from the plasma membrane through the side wall of the plasma membrane due to the pulling of the fluid, and the remaining blood containing the blood flows to the hemodialysis membrane through the connector. Here, through the hemodialysis, the toxins and waste materials in the blood are removed, do.

The separated plasma passes through the plasma flow hole provided in the plasma separation filter housing and moves to the plasma flow section. When the plasma passes the plasma flow section, the plasma is separated from the plasma by the contact with the adsorbent provided in the plasma flow section, Toxins and waste products are removed. The clean plasma that has passed through the adsorbent is returned to the blood flow tube through the plasma pump.

Also, through the operation of the dialysis fluid supply device, the dialysis fluid is supplied to the hemodialysis filter or discharged from the hemodialysis filter. Through the coupling of the upper cap and the hemodialysis filter, the flow port provided in the upper cap and the hemodialysis filter housing The prepared flow holes are connected to each other to form an upper cap channel, through which the dialysis liquid is supplied to the hemodialysis filter or discharged from the hemodialysis filter.

As described above, when one dialysis fluid channel is included, it is preferable that the time for supplying the clean dialysis fluid to the hemodialysis filter by the dialysis fluid supply device alternates with the time for which the used dialysis fluid is discharged from the hemodialysis filter. In addition, the number, the position, and the shape of the channel for the dialysis fluid flow may be changed. For example, the dialysis fluid channel configured to pass through the upper cap may be installed to penetrate the hemodialysis filter housing and the wall, Two separate dialysis fluid channels may be provided to separate the effluent.

Finally, the hemodialysis filter may be changed to a function of a hemofiltration filter for removing water in blood as well as a function of hemodialysis through the flow of a dialysis liquid.

As described above, the blood purifying filter according to the present invention is characterized in that it comprises a plasma separation procedure for separating plasma from blood, an adsorption procedure for removing hepatic toxin or protein-binding toxin from separated plasma, By integrating the hemodialysis procedure for removing toxins, it is possible to simplify and miniaturize the entire blood purification apparatus by using not only the blood of the patient who needs blood purification therapy efficiently, but also the one filter, The convenience of use can be improved.

1 is a cross-sectional view showing an internal configuration of a blood purification filter according to a first embodiment of the present invention.
FIG. 2 is an exploded cross-sectional view of a blood purification filter according to a first embodiment of the present invention showing a coupling structure between a plasma separation filter, a hemodialysis filter, and a housing including a lower cap and an upper cap.
3 is a perspective view of the plasma separation filter.
4 is a perspective view of a hemodialysis filter.
5A and 5B are enlarged views of the cross section of the hemodialysis filter and the upper cap.
6 is a cross-sectional view of the blood purification filter according to the first embodiment of the present invention in which the dialysis fluid channel is formed to penetrate the wall.
FIGS. 7 and 8 are cross-sectional views of a blood purifying filter provided with two dialysis fluid channels for separating the inflow and outflow of the dialysis fluid.
9 is a perspective view of the separating wall.
10 is a cross-sectional view of a blood purifying filter according to a first embodiment of the present invention including an intermediate wall.
11 is a schematic view of a blood purifying apparatus including a blood purifying filter according to the present invention.
12 is a cross-sectional view illustrating plasma flow in the blood purifying filter according to the first embodiment of the present invention.
FIG. 13 is a cross-sectional view showing the flow of dialysis fluid in the blood purification filter according to the first embodiment of the present invention.
FIG. 14 is a sectional view showing the internal structure of the blood purification filter according to the second embodiment of the present invention. FIG.
15 and 16 are sectional views of a blood purifying filter according to a second embodiment of the present invention in which the dialysis fluid channel is changed.
17 is a schematic view of a blood purification apparatus including a blood purification filter according to a second embodiment of the present invention.

Hereinafter, a blood purifying filter according to a first embodiment of the present invention will be described in detail with reference to the accompanying drawings.

In describing the present invention, the sizes and shapes of the components shown in the drawings may be exaggerated or simplified for clarity and convenience of explanation. In addition, the terms defined in consideration of the configuration and operation of the present invention may be changed according to the intention or custom of the user, the operator. These terms are to be construed in accordance with the meaning and concept consistent with the technical idea of the present invention based on the contents throughout the present specification.

FIG. 1 is a sectional view showing the internal structure of the blood purifying filter 100 according to the first embodiment of the present invention. FIG. 2 is a sectional view showing the plasma separating filter 130, the hemodialysis filter 140, Sectional view of the blood purifying filter 100 showing the coupling structure with the housing including the upper cap 120, FIGS. 3 and 4 are perspective views of the plasma separation filter 130 and the hemodialysis filter 140, respectively, and FIG. 5 is an enlarged view of the coupling section of the hemodialysis filter 140 and the upper cap 120.

1 and 2, the blood purification filter 100 according to the present invention includes a plasma separation filter 130 for separating plasma from blood when blood flows into one side, a blood separation filter 130 connected to the plasma separation filter, And a hemodialysis filter 140 and a hemodialysis filter 140. The plasma separation filter 130 and the hemodiafiltration filter 140 provide a space for installing the plasma separation filter 130 and the hemodiafiltration filter 140, A housing for partitioning a plasma flow region 108 outside the plasma flow region 108, and at least one plasma outlet 123 for discharging plasma passing through the plasma flow region 108. The housing includes a tubular wall 102, a lower cap 110 coupled to the plasma separation filter 130 at a lower side of the wall 102, a hemodialysis filter 140 disposed above the wall 102, And an upper cap 120 coupled to the upper cap 120.

The lower cap 110 is provided with a lower cap insertion groove 112 so as to be easily coupled to the lower cap blood port 111 for blood flow and the plasma separation filter 130, An upper cap blood port 121 for blood flow and an upper cap insertion groove 124 for easily coupling the blood dialysis filter 140 and an upper cap flow port 122 for dialysate flow are provided. The hemodialysis filter 140 may include a connection port 101 for connecting the plasma separation filter 130 and the hemodiafiltration filter 140 to prevent blood leaking. The dimensions and shape of the filter 130 may be changed to secure the coupling.

3, the plasma separation filter 130 includes a plasma separation filter housing 131 having an inner space and a plasma separation membrane 132 accommodated in the inner space of the housing. The plasma separation filter housing 130 includes a cylindrical plasma separation filter housing 131, A hollow fiber membrane type plasma separating filter is generally used in which a bundle of hollow fiber membrane separators 132 is loaded on both ends of the hollow fiber membrane type plasma separating membrane 132 and potting is performed using synthetic resin such as polyurethane. The inner space of the plasma separation filter housing 131 is partitioned into a blood flow area and a plasma flow area by the plasma separation membrane 132. The blood introduced into one side of the plasma separation filter 130 flows into the blood flow inside the plasma separation membrane 132 And the plasma is separated through the side wall of the plasma separation membrane 132 in a radial direction. In addition, the plasma separation filter housing 131 is provided with a plasma flow hole 133 so that separated plasma can flow into the plasma flow section 108.

3, it is preferable that a plurality of the plasma flow holes 133 are formed so as to surround the plasma separation filter housing 131 in a transverse direction for smooth plasma flow, and the plasma separation filter 130 Is connected to the hemodialysis filter 140 through the connection port 101 and the other end is coupled to the lower cap 110. Through the coupling with the lower cap 110, The blood that passes through the plasma separation filter 110 flows into the blood flow area inside the plasma separation filter 130.

4, the hemodialysis filter 140 includes a hemodialysis filter housing 141 having an inner space and a blood dialysis membrane 142 accommodated in the inner space of the housing, and the cylindrical hemodialysis filter housing 141 A hollow fiber membrane type hemodialysis membrane filter having a bundle of hollow fiber membrane type hemodialysis membranes 142 mounted on both ends thereof and potting using synthetic resin such as polyurethane is mainly used. The inner space of the hemodialysis filter housing 141 is partitioned into a blood flow area and a dialysis fluid flow area by the hemodialysis membrane 142 and an upper cap flow hole 143 is provided in the hemodialysis filter housing 141 Respectively.

5A and 5B, when the hemodialysis filter 140 and the upper cap 120 are coupled to each other, the upper cap flow port 122 and the hemodialysis filter housing 131, which are provided in the upper cap 120, And the upper cap flow channel 144 is connected to the upper cap flow channel 143. The dialysis liquid flows into the dialysis fluid flow region 149 in the hemodialysis filter 140 through the upper cap flow channel 144, And the filtered dialysis solution or the filtrate which has been removed through the blood dialysis membrane 142 and the moisture in the blood and the waste water is discharged from the hemodialysis filter 140 through the upper cap channel 144 in the same manner. Through the coupling of the hemodialysis filter 140 and the upper cap 120, blood passing through the upper cap blood port 121 is divided to flow into the blood flow area inside the hemodialysis filter 140 . That is, through the coupling between the upper cap 120 and the hemodiafiltration filter 140, the blood and the dialysis fluid are limited to flow into the predetermined area. This is because the connection between the upper cap 120 and the hemodialysis filter 140 Or a method of inserting a soft O-ring such as silicone into each bonding site can be used to prevent the blood and the dialysis solution from flowing into the other space outside the defined space.

The upper cap flow hole 122 and the upper cap flow hole 143 and the upper cap flow channel 144 formed through the connection of the upper cap flow hole 122 and the upper cap flow hole 143 are not limited to the shape and position shown, It can be changed to another structure. 6, a wall fluid hole 145 is formed in the side wall of the hemodialysis filter housing 141, and is connected to the wall fluid hole 145 and penetrates the wall body 102 The wall channel 146 may be provided at an intermediate portion in the longitudinal direction of the hemodialysis filter 140 to increase the contact area between the dialysis liquid and the hematological dialysis membrane 142 It is preferable.

As shown in FIG. 7, an upper cap channel 144 provided in the upper cap 120 and an upper cap channel 144 provided in the hemodialysis filter housing 141, as shown in FIG. 7, may be provided to separate the inflow and outflow of the dialysis liquid. And a wall fluid passage 146 provided on a side wall of the hemodialysis filter 140. When the dialysis fluid is supplied to the hemodialysis filter 140 through any one of the fluid channels, the used dialysis fluid or filtrate is discharged through the other fluid channel . At this time, it is preferable that the wall passage 146 is installed in the direction opposite to the upper cap passage 144 to increase the contact area between the dialysis solution and the blood dialysis membrane 142. 8, two wall flow holes 145 are provided on the side walls of the hemodialysis filter housing 141, and are connected to the wall flow holes 145, respectively, and the wall 102 And two separate wall flow paths 146 installed to penetrate through the wall.

The adsorbent that can be included in the blood purifying filter 100 according to the present invention may be an adsorbent such as Brilirubin which binds to plasma proteins Anion exchange resin for eliminating charged toxins by an ion exchange mechanism, or activated carbon capable of removing tryptophan and a water-soluble toxin having a large molecular size by physical adsorption. The adsorbent may be used in powder form, granular form, or in the form of an adsorbent block in which the powder or granules are squeezed, and the type and number of adsorbents included in the blood purifying filter according to the present invention are not limited to specific adsorbents , And patients who need blood purification therapy.

1, the plasma flow hole 133 is formed in the plasma flow hole 133 so that the plasma introduced through the plasma flow hole 133 can sufficiently be contacted with the adsorbent provided in the plasma flow region 108, It is preferable that the plasma outlet 123 is provided at a lower side of the plasma separation filter housing 131 and that the plasma outlet 123 is provided in the wall 102 which is positioned toward the side where the upper cap 120 or the upper cap 120 is located Do. However, in order to smoothly flow plasma, the plasma flow hole 133 may be provided over or over the plasma separation filter housing 131. In order to smoothly discharge plasma, the plasma outlet 123 may include a plurality of Can be installed.

Here, it is preferable that no adsorbent migrate through the plasma flow hole 133 and the plasma outlet 123, and various methods can be used for this purpose. For example, the plasma flow hole 133 or the plasma outlet 123 may be made smaller than the size of the adsorbent, or the plasma flow hole 133 or the plasma outlet 123 may be formed as a filter having a pore size smaller than that of the adsorbent Or adsorbent block in which the adsorbent is wrapped with a filter having a pore size smaller than that of the adsorbent or in which adsorbent in powder or granular form is squeezed or the adsorbent block in which the adsorbent and the plasma flow hole 133 or the adsorbent and the plasma outlet The separation wall 103 may be provided between the partition wall 123 and the partition wall 103. [ The separating wall 103 may be made of a structure having a pore size smaller than that of the adsorbent in order to suppress the passage of the adsorbent, or may have a pore size smaller than that of the adsorbent in the support wall 104, And a filter 105 attached thereto.

Likewise, in order to prevent mixing of the adsorbents when a plurality of adsorbents are used, the adsorbent may be wrapped with a filter having pores smaller than the size of the adsorbent, an adsorbent block in which a powder or granular adsorbent is compressed, And the separation wall 103 can be installed between the adsorbents.

Finally, in order to further increase the effective contact area between the plasma and the adsorbent in the plasma flow section 108, an intermediate wall 106 may be provided, as shown in FIG. The intermediate wall 106 is located inside the plasma flow section 108 and is fixed to the lower cap 110 and has an outflow hole 107 in a direction shifted toward the side where the upper cap is located. When the intermediate wall 106 is installed, it is preferable that the plasma outlet 123 is installed in the wall 102 which is offset to the side where the lower cap 110 or the lower cap is located.

Hereinafter, the operation of the blood purifying filter 100 and the blood purifying device 200 including the same according to the first embodiment of the present invention will be described with reference to the accompanying drawings.

FIG. 11 is a schematic view of a blood purifying apparatus 200 including a blood purifying filter 100 according to the present invention. FIG. 12 is a view showing plasma flow in the blood purifying filter 100 according to the first embodiment of the present invention And FIG. 13 is a cross-sectional view showing the flow of dialysis fluid in the blood purification filter 100 according to the first embodiment of the present invention.

As shown in FIG. 11, when the blood pump 210 operates and blood of a patient flows into the plasma separation filter 130 through the lower cap blood port 111, due to fluid pulling by the plasma pump 214 The pressure of the plasma region in the plasma separation filter 130 becomes lower than that in the blood region and the plasma is separated through the side wall of the plasma separation membrane 132. The remaining blood containing blood cells flows to the hemodialysis filter 140 through the connector 101. After the toxins and waste materials in the blood are removed through the hemodialysis, the remaining blood including the blood cells passes through the upper cap blood port 121, Lt; / RTI > The blood purification filter 100 is connected to the patient through the blood flow pipe 211 and the blood pump 210 is installed in the blood flow pipe 211. Similarly, the plasma pump 214 is installed on the plasma flow tube 215 connecting the plasma outlet 123 and the blood flow pipe 211, and particularly, independently adjusts the plasma flow rate passing through each plasma outlet 123 A plasma pump 214 connected to each plasma outlet 123 may be provided. 11, the blood pump may be provided at the front end and the rear end of the blood purifying filter 100 in order to adjust the blood flow rate passing through the plasma separation filter 130 and the hemodialysis filter 140, The blood pump 210a for separating plasma and the blood pump 210b for hemodialysis.

12, the separated plasma passes through the plasma flow hole 133 provided in the plasma separation filter housing 131 and moves to the plasma flow section 108. In the plasma flow section 108, The toxins and waste materials present in the plasma are removed. The clean plasma having passed through the adsorbent is returned to the blood flow pipe 211 via the plasma pump 214.

The dialysis liquid is supplied to the hemodialysis filter 140 through the upper cap channel 144 by the operation of the dialysis liquid supply device 212 as shown in FIG. And is discharged from the hemodialysis filter 140 through the dialysis filter 140. As described above, the blood purifying filter 100 according to the first embodiment of the present invention has one dialysis solution flow path. In this case, the dialysis solution is supplied to the hemodialysis filter 140 by the dialysis solution supply device 212 And the time during which the used dialysis liquid is discharged from the hemodialysis filter 140 alternately. As described above, the dialysis fluid flow path included in the blood purifying filter 100 according to the first embodiment of the present invention is not limited to being provided so as to pass through the upper cap 120 as shown in FIG. 13, Position, and number may be changed.

In the blood purifying filter 100 according to the first embodiment of the present invention, the flow of blood flows into the lower cap blood port 111 and flows through the plasma separation filter 130 and the hemodialysis filter 140, The hemodialysis filter 130 is not limited to the case where the hemodialysis fluid is returned to the patient through the hemostasis filter 121 but flows into the hemodialysis filter 140 through the upper cap blood port 121. Here, The blood can be returned to the patient through the lower cap blood port 111. [

The hemodialysis filter 140 may be operated by the dialysis fluid supply device 212 so as not to supply and discharge the dialysis fluid by the dialysis fluid supply device 212, The function of the blood filtration filter in which the pressure of the dialysis fluid flow region 149 is lower than that of the blood, whereby the filtrate in the blood is removed through the flow paths 144, 146.

Hereinafter, a blood purifying filter 100 according to a second embodiment of the present invention will be described in detail with reference to the accompanying drawings.

FIG. 14 is a sectional view showing the internal structure of the blood purification filter 100 according to the second embodiment of the present invention. 15 and 16 are sectional views of the blood purification filter 100 according to the second embodiment of the present invention in which the dialysis fluid channel is changed.

As shown in FIG. 14, the blood purifying filter 100 according to the second embodiment of the present invention includes a plasma separation filter 130 for separating plasma from blood when blood flows in one direction, a plasma separation filter 130 The plasma separation filter 130 and the hemodiafiltration filter 140 are provided in parallel to the plasma separation filter 130 and the hemodialysis filter 140 to remove toxins and wastes from the blood, A housing for partitioning the plasma flow section 105 outside the hemodialysis filter 140 and a plasma outlet 113 for discharging the plasma that has passed through the plasma flow section 105. The housing includes a tubular wall 102, a lower cap 110 coupled to the plasma separation filter 130 and the hemodialysis filter 140 on the lower side of the wall, And an upper cap 120 which is coupled to the hemodialysis filter 130 and the hemodialysis filter 140.

The lower cap 110 includes a first lower cap blood port 116 connected to the plasma separation filter 130, a second lower cap blood port 117 connected to the hemodialysis filter 140, The upper cap 120 includes a lower cap inserting groove 122 to be easily coupled to the separation filter 130 and the hemodialysis filter 140. The upper cap 120 includes a first upper cap 120 connected to the plasma separation filter 130, And a second upper cap blood port 127 connected to the hemodialysis filter 140 and an upper cap inserting unit 130 to be easily coupled to the plasma separation filter 130 and the hemodialysis filter 140. [ Grooves 114 are included. The upper cap 120 may be provided with an upper cap flow port 122 for the flow of the dialysis liquid.

The plasma separation filter 130 includes a plasma separation filter housing 131 having an inner space and a plasma separation membrane 132 accommodated in an inner space of the housing. The inner space of the plasma separation filter housing 131 is connected to the plasma separation membrane (132) into a blood flow region and a plasma flow region. The plasma separation filter housing 131 is provided with a plasma flow hole 133 so that separated plasma can flow into the plasma flow section 108. As shown in FIG. 14, it is preferable that a plurality of the plasma flow holes 133 are formed so as to surround the plasma separation filter housing 131 in a transverse direction for smooth plasma flow. Both ends of the plasma separation filter 130 are coupled to the lower cap 110 and the upper cap 120 to pass through the first lower cap blood port 116 and the first upper cap blood port 117 The blood is partitioned into the blood flow region inside the plasma separation filter 130. [

The hemodialysis filter 140 includes a hemodialysis filter housing 141 having an inner space and a blood dialysis membrane 142 accommodated in an inner space of the housing. The inner space of the hemodialysis filter housing 141 is filled with the blood And is partitioned into a blood flow region and a dialysis fluid flow region by the dialysis membrane 142. Both ends of the hemodialysis filter 140 are coupled to the lower cap 110 and the upper cap 120 to pass through the second lower cap blood port 117 and the second upper cap blood port 127 To the blood flow area inside the hemodialysis filter (140).

An upper cap flow hole 143 is provided in the hemodialysis filter housing 141 for the flow of a dialysis fluid and an upper cap 120 is connected to the upper cap 120 when the hemodialysis filter 140 and the upper cap 120 are coupled. An upper cap flow hole 122 provided in the hemodialysis filter housing 131 is connected to an upper cap flow hole 143 formed in the hemodialysis filter housing 131 to form an upper cap flow channel 144, The filtrate flows. Here, the upper cap flow hole 122, the upper cap flow hole 143, and the upper cap flow channel 144 formed through the connection of the upper cap flow hole 122 and the upper cap flow hole 143 are not limited to the shape and position shown, Structure. For example, the dialysis fluid flow path provided in the upper cap 120 can be changed to be installed in the lower cap 110, as shown in FIG. 15, in order to separate the inflow and outflow of the dialysis fluid, The lower cap 110 and the upper cap 120 are provided with flow ports 118 and 122 respectively and the hemodialysis filter housing 141 is provided with a lower cap flow hole 147 and an upper cap flow hole 143 An upper cap flow passage 144 for connecting the upper cap flow hole 112 and the upper cap flow hole 143 when the hemodialysis filter 140 is coupled to the lower cap 110 and the upper cap 120, A lower cap passage 148 connecting the lower cap flow hole 118 and the lower cap flow hole 147 may be additionally formed. 16, a wall flow hole 145 is formed in a side wall of the hemodialysis filter housing 141, and is connected to the wall flow hole 145 and is formed to penetrate the wall 102 A wall flow passage 146 may be provided.

The plasma flow section 108 is equipped with an adsorbent to remove toxins and waste materials present in plasma. The adsorbent may be used in powder form, granular form, or in the form of an adsorbent block in which the powder or granules are squeezed, and the adsorbent included in the blood purifying filter according to the second embodiment of the present invention is classified into It is not limited to a specific adsorbent, but is preferably changed depending on the patient who needs blood purification therapy.

The plasma flow hole 133 is formed in the plasma separation filter housing 131 so that the plasma introduced through the plasma flow hole 133 can sufficiently be contacted with the adsorbent provided in the plasma flow section 108 and then discharged. And the plasma outlet 123 may be provided on the wall 102 which is offset to the side where the upper cap 120 or the upper cap 120 is located. However, in order to smoothly flow plasma, the plasma flow hole 133 may be provided over the entire or the entire plasma separation filter housing 131, and a plurality of plasma outlets 123 may be installed .

Here, it is preferable that no adsorbent migrate through the plasma flow hole 133 and the plasma outlet 123. For this purpose, various methods can be used as described above, and similarly, When the adsorbent is used, it is preferable that the adsorbent is not mixed with each other by using the separating wall 103 or the like.

Finally, in order to further increase the effective contact area between the plasma and the adsorbent, the plasma is positioned in the plasma flow section 108 and fixed to the lower cap 110, The plasma outlet 123 may be installed in the wall 102 that is offset to the side where the lower cap 110 or the lower cap is located when the intermediate wall 106 is installed. .

Hereinafter, a blood purification filter 100 according to a second embodiment of the present invention and a blood purification device 200 including the same will be described in detail with reference to the accompanying drawings.

17 is a schematic view of a blood purification apparatus 200 including a blood purification filter 100 according to a second embodiment of the present invention.

The blood pump 210 operates so that blood flows into the plasma separation filter 130 and the hemodialysis filter 140 through the first and second lower cap blood ports 116 and 117 as shown in FIG. The plasma is separated through the side wall of the plasma separating membrane 132 and the remaining blood containing the blood cells is discharged to the patient through the first upper cap blood port 126 Lt; / RTI > At the same time, the hemodialysis filter 140 removes toxins and waste materials from the blood, and is returned to the patient through the second upper cap blood port 127. The blood purification filter 100 is connected to the patient's body through the blood flow pipe 211 and the blood pumps 210a and 210b are installed on the blood flow pipe 211. [ Similarly, the plasma pump 214 is installed on the plasma flow tube 215 connecting the plasma outlet 123 and the blood flow pipe 211, and particularly, independently adjusts the plasma flow rate passing through each plasma outlet 123 A plasma pump 214 connected to each plasma outlet 123 may be provided. 17, the blood pump includes a blood pump 210a for plasma separation and a blood pump 210a for hemodialysis to independently adjust the blood flow rate to the plasma separation filter 130 and the hemodialysis filter 140. [ And may be installed separately by the blood pump 210b.

The separated plasma passes through the plasma flow hole 133 provided in the plasma separation filter housing 131 and moves to the plasma flow section 108. In the plasma flow section 105, Toxins and waste products are removed. The clean plasma having passed through the adsorbent is returned to the blood flow pipe 211 via the plasma pump 214.

A clean dialysis solution is supplied to the hemodialysis filter 140 through the upper cap channel 144 by the operation of the dialysis fluid supply device 212 and the used dialysis solution is supplied to the hemodialysis filter 140 via the upper cap channel 144, (Not shown). In this case, the blood purifying filter 100 according to the second embodiment of the present invention has one flow path for the dialysis fluid flow. In this case, the dialysis fluid is supplied to the hemodialysis filter 140 And the time during which the dialysis liquid is discharged from the hemodialysis filter 140 are alternately generated. As described above, the dialysis fluid flow path included in the blood purifying filter 100 according to the second embodiment of the present invention is configured to pass through the upper cap 120, but its shape, position, and number can be changed .

In addition, the hemodialysis filter 140 does not supply and discharge the dialysis solution by the dialysis solution supply device 212 in addition to the function of hemodialysis through the flow of the dialysis solution, The function of the hemofiltration filter in which the pressure of the dialysis fluid flow region 149 is lower than that of the blood, whereby the filtrate in the blood is removed through the flow channels 144, 146 is also performed.

As described above, the blood purifying filter 100 according to the present invention includes a plasma separation procedure for separating plasma from blood, an adsorption procedure for removing hepatic toxin or protein-binding toxin from separated plasma, and a urine toxin or a water- By integrating the hemodialysis procedure for removing blood, it is possible not only to efficiently purify the blood of a patient in need of blood purification therapy, but also to miniaturize the entire blood purification apparatus, and by using one filter, And the cost of blood purification treatment can be reduced.

The embodiments of the present invention described above and illustrated in the drawings should not be construed as limiting the technical idea of the present invention, and the scope of protection of the present invention is limited only by the matters described in the claims. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

100: blood purification filter
101: End connector
102: cylindrical wall
103: separating wall
104: Support wall
105: Filter
106: Middle wall
107: Spillway
108: plasma flow section
110: Lower cap
111: Lower cap blood port
112: Lower cap insertion groove
116: first bottom cap blood port
117: second bottom cap blood port
118: Lower cap flow port
120: upper cap
121: Upper cap blood port
122: upper cap flow port
123: Plasma outlet
124: upper cap insertion groove
126: first upper cap blood port
127: second upper cap blood port
130: plasma separation filter
131: plasma separation filter housing
132: plasma membrane
133: plasma flow ball
140: hemodialysis filter
141: hemodialysis filter housing
142: blood dialysis membrane
143: upper cap flow hole
144: upper cap channel
145: Wall flow ball
146:
147: Lower cap flow hole
148: Lower cap channel
149: Dialysis fluid flow area
200: blood purification device
210: Blood pump
210a: blood pump for plasma separation
210b: Blood pump for hemodialysis
211: blood flow tube
212: Dialysis fluid supply device
213: Dialysis fluid flow tube
214: Plasma pump
215: plasma flow tube

Claims (20)

A plasma separation filter (130) for separating plasma in the blood;
A hemodialysis filter (140) for removing toxins and wastes in blood;
A housing for providing a space for installing the plasma separation filter 130 and the hemodialysis filter 140 and partitioning the plasma flow section 108 outside the plasma separation filter 130 and the hemodialysis filter 140; And
And a plasma outlet (123) for discharging plasma that has passed through the plasma flow section (108).
The method according to claim 1,
The plasma separation filter 130 includes a plasma separation filter housing 131 having an inner space and a plasma separation membrane 132 accommodated in the inner space of the housing. The plasma separation membrane 132 separates the plasma separation filter housing 131 ) Is partitioned into a blood flow region and a plasma flow region,
The hemodialysis filter 140 includes a hemodialysis filter housing 141 having an inner space and a blood dialysis membrane 142 accommodated in the inner space of the housing and the hemodiafiltration membrane 142 is connected to the hemodialysis filter housing 141 ) Is partitioned into a blood flow region and a dialysis fluid flow region 149,
Wherein a plasma flow hole (133) is provided at one side of the plasma separation filter housing (131) so that separated plasma can be transferred to the plasma flow section (108).
3. The method of claim 2,
The housing includes:
A tubular wall 102;
A lower cap 110 coupled to the plasma separation filter 130 on the lower side of the wall;
And an upper cap (120) coupled to the hemodialysis filter (140) at an upper side of the wall,
The lower cap 110 and the upper cap 120 are respectively provided with a lower cap blood port 111 and a lower cap 120 so that blood can flow into the blood flow region inside the plasma separation filter 130 and the hemodialysis filter 140, And a cap blood port (121).
The method according to claim 1,
And a connection port (101) connecting between the plasma separation filter (130) and the hemodialysis filter (140) so as to prevent blood leakage.
The method of claim 3, wherein
An upper cap flow hole 143 is provided on one side of the hemodialysis filter housing 141,
The upper cap 120 is provided with an upper cap flow port 122,
And an upper cap flow channel 144 connecting the upper cap flow hole 122 and the upper cap flow hole 143 when the upper cap 120 and the hemodialysis filter 140 are coupled to each other, .
6. The method of claim 5,
A wall flow hole 145 is provided on a side wall of the hemodialysis filter housing 141,
And a wall flow passage (146) connected to the wall flow hole (145) and configured to penetrate the wall (102).
4. The method of claim 3,
A wall flow hole 145 is provided on a side wall of the hemodialysis filter housing 141,
And a wall channel (146) connected to the wall fluid hole (145) and configured to penetrate the wall (102).
3. The method of claim 2,
The housing includes:
A tubular wall 102;
A lower cap 110 coupled to the plasma separation filter 130 and the hemodialysis filter 140 on the lower side of the wall;
And an upper cap 120 coupled to the plasma separation filter 130 and the hemodialysis filter 140 on the upper side of the wall,
The lower cap 110 is provided with first and second lower cap blood ports 116 and 117 for allowing blood to flow into the blood flow region inside the plasma separation filter 130 and the hemodialysis filter 140 ,
The upper cap 120 is provided with first and second upper cap blood ports 126 and 127 for allowing blood to flow into the blood flow region inside the plasma separation filter 130 and the hemodialysis filter 140 Blood purification filter.
The method of claim 8, wherein
An upper cap flow hole 143 is provided on one side of the hemodialysis filter housing 141,
The upper cap 120 is provided with an upper cap flow port 122,
And an upper cap flow passage 144 connecting the upper cap flow hole 143 and the upper cap flow port 122 when the upper cap 120 and the hemodialysis filter 140 are coupled to each other, .
10. The method of claim 9,
A lower cap flow hole 147 is provided on one side of the hemodialysis filter housing 141,
The lower cap 110 is provided with a lower cap flow hole 118,
And a lower cap flow passage 148 connecting the lower cap flow hole 147 and the lower cap flow port 118 when the lower cap 110 and the hemodialysis filter 140 are coupled to each other, Purification filter.
9. The method of claim 8,
A wall flow hole 145 is provided on a side wall of the hemodialysis filter housing 141,
And a wall flow passage (146) connected to the wall flow hole (145) and configured to penetrate the wall (102) is formed.
12. The method according to any one of claims 2 to 11,
And an adsorbent is provided in the plasma flow section (108) to remove toxins and waste materials in the plasma.
13. The method of claim 12,
Wherein the plasma outlet 123 is provided in the wall 102 that is offset toward the side where the upper cap 120 or the upper cap 120 is located.
13. The method of claim 12,
In order to prevent the movement of the adsorbent through the plasma flow hole 133 and the plasma outlet 123,
The plasma flow hole 133 or the plasma outlet 123 may be made smaller than the size of the adsorbent,
The plasma flow hole 133 or the plasma outlet 123 is wrapped with a filter 105 having pores smaller than the size of the adsorbent,
The adsorbent is wrapped with a filter 105 having pores smaller in size than the adsorbent,
Adsorbent block squeezed with a powder or granular adsorbent, or
And a separation wall (103) is provided between the adsorbent and the plasma flow hole (133) or between the adsorbent and the plasma outlet (123).
15. The method of claim 14,
The separating wall (103),
A structure having pores smaller than the size of the adsorbent to prevent passage of the adsorbent or a filter 105 having pores smaller than the size of the adsorbent may be attached to the support wall 104 Blood Purification Filter.
13. The method of claim 12,
And an intermediate wall having an outflow hole 107 for allowing plasma to pass through a portion of the plasma flow section 108 which is fixed to the lower cap 110 and is positioned on the side where the upper cap 120 is located, 106). ≪ / RTI >
17. The method of claim 16,
The blood purification filter according to claim 1, wherein the plasma outlet (123) is provided in a wall (102) biased toward the side where the lower cap (110) or the lower cap is located.
A blood purification filter (100) according to claim 12;
A blood flow tube 211 connecting the blood purification filter 100 and the patient and flowing blood therein;
A blood pump 210 installed in the blood flow tube 211 to transfer blood of the patient;
A plasma flow tube 215 connecting the plasma outlet 123 and the blood flow tube 211 and flowing plasma therein;
A plasma pump 214 installed in the plasma flow tube 215 to transfer plasma; And
And a dialysis fluid supply device (212) for supplying the dialysis fluid to the hemodiafiltration filter (140) or recovering the dialysis fluid or the filtrate from the hemodialysis filter (140).
The method of claim 18, wherein
The blood pump 210 is connected to the blood pump 210a for blood plasma separation and the blood pump 210b for hemodialysis to regulate the blood flow rate passing through the plasma separation filter 130 and the hemodialysis filter 140. [ And the blood purification device is installed separately.
19. The method of claim 18,
And an intermediate wall having an outflow hole 107 for allowing plasma to pass through a portion of the plasma flow section 108 which is fixed to the lower cap 110 and is positioned on the side where the upper cap 120 is located, 106). ≪ / RTI >

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