WO2015152593A1

WO2015152593A1 - Blood purifying apparatus

Info

Publication number: WO2015152593A1
Application number: PCT/KR2015/003139
Authority: WO
Inventors: 조태범; 이경수
Original assignee: 조태범
Priority date: 2014-04-02
Filing date: 2015-03-31
Publication date: 2015-10-08
Also published as: WO2015152593A8

Abstract

A complex function filter according to the present invention comprises: a first filter and a second filter for purifying biological fluid; a housing for partitioning a suction section at the outside of the first filter and the second filter; a fluid channel partition connection hole for connecting the first filter and the second filter to each other; and a housing port for generating a flow through the suction section. The housing comprises: a wall; a first cap coupled to the first filter on one side of the lengthwise direction of the wall; and a second cap coupled to the second filter on the other side of the lengthwise direction of the wall. The complex function filter according to the present invention has a configuration for integrating components for dialysis, adsorption, blood plasma separation, and ultra filtration and achieving a smooth internal flow in order to purify blood or a dialysis fluid. Thus, the present invention can provide a blood purifying apparatus which is entirely simple, can be easily installed and used, and can reduce treatment costs.

Description

[Correction under rule 26. 15.09.2015] blood purification device

The present invention relates to a blood purification device that removes toxins and wastes from blood. More specifically, the entire apparatus is simple and easy to install and use by using a multifunctional filter that integrates the functions of dialysis, adsorption, ultrafiltration or plasma separation. It relates to a blood purification device that is easy to use and can reduce the cost of treatment.

The liver and kidneys perform important functions in our bodies. The liver processes nutrients, synthesizes plasma proteins such as albumin, and decodes alcohol and drugs. The kidneys release urea nitrogen, a protein metabolite, remove excess moisture from the body, and regulate blood pressure. When liver function is impaired, ammonia and bilirubin are removed through liver metabolism, causing substances to accumulate in the body, causing complications such as jaundice, hepatic coma, acute renal failure, systemic inflammatory reactions, and multiple organ failure. Likewise, if the kidney function is impaired, water and protein metabolites to be released into the body accumulate and cause uremia, cardiovascular diseases, and the like.

Liver transplantation is considered the only treatment for acute liver failure, but based on liver transplant data in the US OPTN / SRTR report released in 2011, only 36% of patients awaiting a transplant are known to have a transplant. In Korea, only 22% of transplant recipients receive liver transplants, according to a report from the National Institute of Organ Transplantation. This is because the number of donors donated is significantly shorter than that of patients in need of transplantation. The same is true for kidney transplants, in which only about 30% of patients with end-stage renal failure are known to have kidney transplants. If a liver transplant or kidney transplant fails in a timely manner, blood purification should be performed to circulate blood outside the body to remove toxins from the blood through dialysis, filtration, or adsorption.

Phosphorus devices currently used in clinical practice are limited to equipment called Gambro's MARS and FMC's Prometheus, which separates plasma from blood, removes toxins from separated plasma using an ion resin adsorbent, and separates and adsorbs plasma. After hemodialysis is composed. In other words, Prometheus includes a plasma separation filter, two adsorption filters to remove toxins from plasma, and a hemodialysis procedure, which makes the system complicated and requires expensive treatment costs.

MARS, like hemodialysis, consists of a hemodialysis filter that removes hepatoxins in the blood through a dialysis filter, with a semi-permeable membrane interposed between the blood and the dialysate, and mass exchange between the blood and the dialysate. However, in comparison with the hemodialysis device for a conventional renal failure patient, MARS can remove various protein binding toxins and hepatoxins as well as urinary toxins through a dialysis filter by using a plasma protein called albumin in a dialysis solution. . At this time, the albumin dialysate is reused, and another dialysis filter, activated carbon, and an ion resin adsorbent are used for regeneration of the dialysate. Therefore, not only the use of expensive albumin but also several stages of dialysis filter and adsorption filter for dialysis liquid regeneration, which is complicated system and expensive treatment cost like Prometheus.

In order to solve the above problems, the whole device is simple, easy to install and use, and ultimately to reduce the treatment cost by using a multi-functional filter that integrates dialysis, adsorption, and ultrafiltration or plasma separation. An object of the present invention is to provide a blood purification device that can be saved.

A multifunctional filter according to the present invention for achieving the above object, the first filter and the second filter, the first filter and the first filter for purifying a biological fluid (blood, plasma, or used dialysate, etc.) 2 The housing that separates the adsorption section outside the filter, is installed in the housing and comprises a housing port so that flow through the adsorption section can occur. The housing includes a wall, a first cap coupled to the first filter on one side in the longitudinal direction of the wall, and a second cap coupled to a second filter on the other side in the longitudinal direction of the wall. In addition, the multi-function filter according to an embodiment of the present invention may be configured to include a flow passage block connecting the first filter and the second filter so that there is no leakage of fluid between the first filter and the second filter.

The first filter and the second filter have a form in which a semipermeable separator is filled in a cylindrical container and potted using synthetic resin such as polyurethane at both ends thereof. Inner spaces of the first and second filter containers are partitioned so that two different fluids flow by the separator.

Here, the first and second filter container is characterized in that the flow hole is provided on at least one side of both sides in the longitudinal direction around the longitudinal stop of the container. For example, a first flow hole may be provided at a side coupled to the first cap of the first filter container, and a third flow hole may be provided at a position biased to the side where the second cap of the second filter container is located.

The first and second caps comprise a filter port coupled to the cap port and a filter to allow fluid to pass therethrough, and the cap and the filter are coupled so that the fluid passing through the cap port flows to one side of the filter separation membrane. . Further, at least one of the first and second caps is characterized in that it comprises a passage through the cap and one end adjacent to the filter engaging portion of the cap. That is, the first cap may have a first passage adjacent the filter engagement portion and the other end adjacent the outer surface of the cap.

The first passage is characterized in that the first cap is coupled with the first filter to form a flow path through which fluid can flow into the first filter. One side of the first filter container is positioned at the first cap filter coupling unit, such that the first filter and the first cap are coupled to each other. The first filter and the first cap are coupled to each other to form a first flow path through which the fluid passing through the first passage may flow into the first filter through the first flow hole provided in the first filter container.

The adsorption section is provided with an adsorbent to remove toxins and wastes. Adsorbents include anion exchange resins that bind to plasma proteins, such as bilirubin, and remove toxins that are charged by ion exchange mechanisms, or activated carbon that removes tryptophan and water-soluble toxins of medium molecular size by physical adsorption. Can be. The type and number of adsorbents are not limited, and the adsorbent is preferably changed according to the patient in need of blood purification therapy.

The housing port and the third flow hole are preferably provided on the opposite side in the longitudinal direction of the composite function filter so that the fluid introduced through the housing port can flow into the second filter after sufficiently contacting with the adsorbent in the adsorption section. At this time, it is preferable that the movement of the adsorbent does not occur through the housing port and the flow hole, and various methods may be used for this purpose. For example, the housing port or the flow hole may be made smaller than the adsorbent, the housing port or the flow hole may be wrapped with a mesh filter, or a separation wall may be installed between the adsorbent and the housing port or the adsorbent and the flow hole.

Blood purification apparatus according to an embodiment of the present invention may be divided into a case in which the multi-function filter is in contact with the blood of the patient and the other case. When the combined function filter is in contact with the blood of the patient, the blood purification device according to an embodiment of the present invention comprises a combined function filter, a flow pipe connecting the combined function filter and the patient, the pump is installed in the flow pipe and transfers blood Can be. In this case, it is preferable that hemodialysis occurs in the first filter and plasma separation occurs in the second filter.

When blood enters, plasma is separated from the blood in the second filter. The separated plasma flows through the third flow hole to the adsorption section, where toxins and wastes are removed through contact with the adsorbent. The plasma passing through the adsorption section is returned to the flow tube through which the blood flows through the housing port. Residual blood from the second filter travels through the flow passage connector to the first filter where dialysis takes place. Dialysis fluid may be supplied to or discharged from the first filter through a first flow path connecting the first passage and the first flow hole. The dialysate may be prepared by using a pre-formed dialysate bag or by adjusting pH, electrolyte concentration, etc. in ultrapure water generated through a water treatment system.

On the other hand, when the multi-function filter does not directly contact the blood of the patient, the blood purification device according to an embodiment of the present invention, the blood filter and the blood filter that the substance transfer between the blood and the dialysate is connected and the blood or dialysate is It may be composed of a flowing flow tube, a pump installed in the flow tube to transfer blood or dialysate, and a combined function filter to purify the dialysate used. At this time, it is preferable that diafiltration takes place in the first filter and ultrafiltration occurs in the second filter. The multifunction filter removes toxins and wastes from the used dialysate and readjusts the electrolyte concentration to reuse the dialysate.

As described above, the blood purification apparatus according to an embodiment of the present invention uses a multifunctional filter integrating dialysis through the first filter, plasma separation or ultrafiltration through the second filter, and adsorption in the adsorption section. In this way, the blood purification device can be efficiently purified, and the whole device can be provided with a simple, easy installation and use, and a blood purification device that can reduce the treatment cost.

1 and 2 are a cross-sectional view, a perspective view and an exploded view of a composite function filter according to an embodiment of the present invention.

3 shows a flow passage connector and first and second filters.

4 shows a coupling cross section of the first cap and the first filter.

5 is a perspective view of the dividing wall.

6 is a schematic diagram of a blood purification apparatus according to an embodiment of the present invention.

7 shows an example flow inside a multifunction filter.

8 is a sectional view and a perspective view of the blood filter.

9 illustrates an example flow within a multifunction filter.

10 is a cross-sectional view and a perspective view of the composite function filter separating the inflow and outflow of the dialysate through the first filter.

11 shows the flow passage connector and the first filter vessel.

12 shows the engagement cross section of the first cap, the first filter, and the flow passage segment connector.

13 is a sectional view and a perspective view of a multifunction filter configured to allow a third flow path through the second cap;

14 shows a second filter vessel in which a third flow hole is installed.

FIG. 15 illustrates an example flow inside a multifunction filter configured to allow a third flow path through the second cap.

16 is a sectional view and a perspective view of a composite function filter having a fourth flow path.

FIG. 17 shows a second filter vessel further provided with a flow passage connector and a fourth flow hole.

18 shows the engagement cross section of the second cap, the second filter, and the flow passage connector.

19 shows an example flow inside a composite function filter having a fourth flow path.

20 and 21 illustrate a cross-sectional view and a perspective view of a composite function filter having flow passage connector flow holes and internal flows.

Hereinafter, a multifunction filter and a blood purification device including the same according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

In describing the present invention, the size or shape of the components shown in the drawings may be exaggerated or simplified for clarity and convenience of description. In addition, terms that are specifically defined in consideration of the configuration and operation of the present invention may vary depending on the intention or custom of the user or operator. These terms should be interpreted as meanings and concepts corresponding to the technical spirit of the present invention based on the contents throughout the specification.

As shown in Figures 1 and 2, the multi-function filter 10 according to an embodiment of the present invention is a first filter 20 for purifying a biological fluid (blood, plasma, or used dialysate, etc.) ), Also a housing for partitioning the adsorption section 12 outside the first filter and the second filter, while providing a second filter 30 for the purification of the biological fluid, an installation space for the first filter and the second filter, And a housing port 13 installed in the housing to allow flow to occur through the adsorption section. The housing includes a wall 11, a first cap 40 coupled to the first filter on one side in the longitudinal direction of the wall, and a second cap 50 coupled to the second filter on the other side in the longitudinal direction of the wall. In addition, the multi-function filter 10 according to an embodiment of the present invention includes a flow path connecting connector 60 for connecting the first filter and the second filter so that there is no leakage of fluid between the first filter and the second filter. Can be. As shown in FIG. 3 (a), the flow passage connector may have connecting

portions

61 and 62 coupled to the first and second filters, respectively.

As shown in FIGS. 3B and 3C, the first filter 20 and the second filter 30 fill the

cylindrical containers

21 and 31 with the

semi-permeable separation membranes

22 and 32 and at both ends thereof. It has the form which was potted using synthetic resin, such as polyurethane. The figure shows a hollow fiber membrane filter having a hollow fiber membrane, the hollow fiber membrane filter has an advantage of excellent mass transfer efficiency compared to the small size. However, the first and second filters are not limited to being composed of hollow fiber membranes, and may be formed of other types of separation membranes such as flat membranes. The inner spaces of the first and

second filter containers

21 and 31 are partitioned so that two fluids flow by the

separators

22 and 32.

Here, the first and second filter containers (21, 31) is characterized in that the flow hole is provided on at least one side of both sides in the longitudinal direction around the longitudinal stop of the container. For example, as shown in FIGS. 3B and 3C, the first flow hole 23 is provided on the side that is engaged with the first cap of the first filter container 21 and the second filter. The third flow hole 33 may be provided at a position biased toward the side where the second cap of the container 31 is located. It is preferable that a plurality of flow holes 23 and 33 be installed to surround the circumferential direction of the

containers

21 and 31 so that flow can be easily generated.

As shown in FIG. 2, the first cap 40 includes a first cap filter engagement portion 42 that engages the first cap port 41 and the first filter to allow fluid to pass therethrough, and the first cap 40 When the cap is coupled to the first filter, the fluid passing through the first cap port 41 is partitioned to flow to one side of the first filter separator 22 or in the case of the hollow fiber separator. Similarly, the second cap 50 may have a second cap filter coupling portion 52 that engages the second cap port 51 and the second filter, and the second cap is coupled to the second filter by the second cap 50. The fluid passing through the port 51 is partitioned to flow to one side of the second filter separation membrane 32. In the drawings, the

filter coupling parts

42 and 52 are illustrated in the form of concave grooves into which one side of the filter can be inserted. Can be.

In addition, at least one of the caps of the first and

second caps

40 and 50 is characterized in that it comprises a passage that penetrates the cap and one end thereof is adjacent to the

filter coupling portions

42 and 52 of the cap. . For example, the first cap shown in FIG. 2 has a first passage 43 one end adjacent to the first filter filter coupling portion 42 and the other end adjacent to the outer surface of the cap. Here, the cap outer surface means the side of the cap except the cap surface in contact with the suction section 12 or the surface on which the

cap ports

41 and 51 are located. It can be seen that the outer surface of the cap corresponds to the outside of the multifunction filter.

The first passage 43 forms a flow path through which the fluid can flow into the first filter by coupling the first cap with the first filter. 4 shows a first flow path 71 generated through the combination of the first cap 40 and the first filter 20. One side of the first filter container 21 is positioned in the first cap filter coupling part 42, so that the first filter and the first cap are coupled to each other. Two flow paths are partitioned when the first filter and the first cap are coupled, and one is partitioned so that the fluid passing through the first cap port 41 flows to one side of the first filter separation membrane 22 as described above. The other is partitioned so that the fluid passing through the first passage 43 provided in the first cap flows into the first filter through the first flow hole 23 provided in the first filter container. That is, a first flow path 71 connecting the first passage 43, the first flow hole 23, and the first filter 20 is formed through the combination of the first filter and the first cap.

As such, the fluid flows through the combination of the

caps

40 and 50 and the

filters

20 and 30 to a predetermined region, and various methods may be used for this purpose. The fluid can be prevented from flowing to other spaces through a variety of methods, such as through chemical bonding to the cap and filter, or by inserting a soft O-ring such as silicone into each bonding site.

The adsorption section 12 is provided with an adsorbent to remove toxins and wastes. Adsorbents are attached to plasma proteins, such as bilirubin, to remove the charged toxins by ion exchange mechanisms, or tryptophan and medium-molecularly water-soluble toxins. Activated carbon may be used. The adsorbent may be used in powder form, in the form of granules, or in the form of an adsorbent block in which the powder or granules are compressed. The adsorbents included in the multifunctional filter according to an embodiment of the present invention are not limited in kind and number. It is desirable to vary according to the patient in need of blood purification therapy.

The housing port allows the fluid introduced through the housing port 13 to flow into the second filter through the third flow hole 33 provided in the second filter container 31 after sufficient contact with the adsorbent in the adsorption section. The first cap 40 or the wall 11 biased to the side where the first cap is located is provided, and the third flow hole is preferably provided at a position biased to the side where the second cap of the second filter container is located. The same is true if the flow occurs in the opposite direction. That is, after the fluid of the second filter is introduced into the adsorption section through the third flow hole, it may be discharged through the housing port through the adsorption section.

At this time, it is preferable that the movement of the adsorbent does not occur through the housing port 13 and the first or third flow holes 23 and 33, and various methods may be used for this purpose. For example, a housing port or flow hole may be made smaller in size than an adsorbent, or the housing port or flow hole may be wrapped in a mesh filter having pores of a smaller size than the adsorbent, or the adsorbent may be a mesh filter having pores of a smaller size than the adsorbent. Or a separation wall 14 may be provided between the adsorbent and the housing port or between the adsorbent and the flow hole, as shown in FIG. The dividing wall is made of a structure having pores of a smaller size than the adsorbent to suppress the passage of the adsorbent, or as shown in FIG. It may be manufactured in the form attached to the mesh filter 14b having a.

Similarly, when two or more adsorbents are used, in order to prevent mixing between the adsorbents, the adsorbents are wrapped in a mesh filter having pores of smaller size than the adsorbents, or an adsorbent block in which powder or granular adsorbents are compressed. Separation wall 14 may be installed between.

Hereinafter, the blood purification apparatus 80 including the multifunction filter 10 will be described in detail with reference to the accompanying drawings.

Blood purification apparatus according to an embodiment of the present invention can be divided into a case in which the multi-function filter is in direct contact with the blood of the patient and the other case. First, when the combined function filter is in contact with the blood of the patient, as shown in Figure 6 (a), the blood purification device according to an embodiment of the present invention connects the combined function filter 10, the combined function filter and the patient It may be configured to include a flow tube 81, the pump 82 is installed in the flow tube to transfer blood. In this case, hemodialysis may occur in the first filter 20 and plasma separation may occur in the second filter 30.

As shown in FIG. 7, when blood flows into the multifunction filter through the second cap 50 by the pump 82, plasma is separated from the blood in the second filter 30. Plasma separated across the second filter separation membrane 32 flows to the adsorption section 12 through the third flow hole 33 provided in the second filter vessel, where toxins and wastes are removed through contact with the adsorbent. do. The plasma passing through the adsorption section is returned to the flow tube 81 through which the blood flows through the housing port 13.

Residual blood of the second filter moves to the first filter 20 via the flow passage connector 60, where dialysis takes place. In order to purify the blood flowing into one side of the first filter membrane, or in the case of the hollow fiber membrane, the dialysis fluid is supplied to the other side of the first filter membrane, or to the outside of the membrane in the case of the hollow fiber membrane. At this time, the dialysate may be supplied to or discharged from the first filter through the first flow path 71 connecting the first passage and the first flow hole. The dialysate may be prepared by using a pre-formed dialysate bag or by adjusting pH, electrolyte concentration, etc. in ultrapure water generated through a water treatment system.

The blood is not limited to being introduced into the second cap, and may be configured to enter the first cap and undergo dialysis first through the first filter, followed by plasma separation through the second filter. As such, the blood of the patient can be efficiently purified through dialysis in the first filter, plasma separation in the second filter, and adsorption in the adsorption section.

On the contrary, when the multi-function filter 10 does not directly contact the blood of the patient, the blood purification apparatus 80 according to an embodiment of the present invention, as shown in Figure 6 (b), between the blood and the dialysate A blood filter 83 in which the movement takes place may be included, and a dialysis fluid circuit for removing toxins from the blood circuit with the blood filter interposed therebetween. The blood circuit is composed of a flow pipe 81 connecting the blood filter and the patient and a pump 82 for transporting blood. Similarly, the dialysis fluid circuit includes a flow pipe 81 through which the dialysate flows and a pump 82 for transporting the dialysate, and It may be composed of a multi-function filter 10 for purifying the dialysate used.

8 shows an example of the blood filter 83. A container 83a having an inner space and a blood membrane 83b accommodated in the inner space of the container are included, and the inner space of the container is divided into a blood flow region and a dialysate flow region by the blood membrane. A blood inlet 83c and a blood outlet 83d are provided at one end and the other end of the blood filter container, and a dialysis fluid inlet 83e and a dialysis fluid outlet 83f are provided at upper and lower outer peripheral surfaces of the container.

At this time, the combined function filter 10 serves to purify the used dialysate. As described above, the dialysate is prepared by adjusting the concentration and pH of various electrolytes such as bicarbonate and sodium in the ultrapure water generated through the water treatment system. In particular, hepatic dialysis contains an additional plasma protein such as albumin in the dialysate, and albumin may act as a medium for removing protein binding toxins present in blood or plasma. The multifunction filter 10 removes toxins and wastes from the used dialysate and readjusts the electrolyte concentration to reuse the dialysate. The regenerated dialysate may be stored in the dialysate reservoir 84 and then supplied to the blood filter.

9 shows an example flow inside a multifunction filter 10 for purifying spent dialysate. As shown in FIG. 9A, the dialysate used by the pump 82 flows into the second filter 30 through the second cap port 51. At this time, a portion of the incoming dialysate is separated and flows to the adsorption section 12, where toxins in the dialysate may be removed through contact with the adsorbent. The dialysate passed through the adsorption section is introduced into the second filter through the third flow hole 33 provided in the second filter container 31, and merges with the dialysate inside the second filter across the second filter separation membrane.

Here, the amount of the dialysate separated to pass through the adsorption section in the dialysate flowing into the composite function filter 10 does not have a predetermined value. The amount of toxin to be removed by adsorption in the dialysate, or the stability of the dialysate flow through the multifunction filter may be adjusted. Thus, all of the used dialysate may be configured to pass through the adsorption section, or vice versa, all used dialysate may be configured to pass through the second cap.

Subsequently, the dialysis liquid that has passed through the second filter flows to the first filter 20 via the flow path segment connector 60, where the dialysis liquid used by dialysis is purified once more. The dialysate is supplied and discharged through the first flow path 71.

The dialysate flow through the multifunction filter 10 is not limited to entering the second cap 50. Used dialysate flows into the first cap 40 and a portion of the dialysate flowing into the first cap may be separated to pass through the adsorption section. The dialysis solution not separated flows to the second filter 30 after the dialysis occurs first while passing through the first filter 20. The second filter merges with the dialysate passed through the adsorption section, and the dialysate passed through the second filter may be supplied to the blood filter 83 again.

In addition, the dialysate flow through the composite function filter 10 according to an embodiment of the present invention, as shown in Figure 9 (b), the dialysate flows into the first cap and the dialysis occurs in the first filter first. A portion of the dialysate is then ultrafiltered across the second filter separator 32 in the second filter. The filtered dialysate flows through the third flow hole 33 to the adsorption section, where toxins are removed by adsorption. The dialysate passed through the adsorption section is returned to the flow tube (81).

Similarly, the amount of the dialysate separated by ultrafiltration in the second filter is preferably not adjusted but considering the adsorption efficiency and flow stability. As described above, the multifunction filter 10 according to an embodiment of the present invention may be configured in various ways in the dialysis fluid flow in consideration of the dialysis fluid purification efficiency and the stability of the dialysis fluid flow.

Here, the pump 82 may be used in various ways to transfer blood, plasma or dialysate. The pump 82 shown in FIG. 6 and FIG. 7 shows a roller pump composed of a roller for transferring the fluid therein by compressing the flow tube 81 and a driving unit for rotating the roller. However, the pump is not limited to a roller pump, but a centrifugal pump for transferring fluid by applying centrifugal force, a flow tube pressurizing pump configured to pressurize the flow tube and a pressurizing member driver, and a piston for compressing or expanding the cylinder and the cylinder. It may be changed into various forms capable of transferring fluid, such as a piston pump or a pneumatic pump that compresses or expands a fluid sac using a pneumatic actuator.

As described above, the multi-function filter 10 according to an embodiment of the present invention is used for blood or blood through dialysis through a first filter, plasma separation or ultrafiltration through a second filter, and adsorption in an adsorption section. The purified dialysate can be efficiently purified.

Here, the multifunction filter 10 may be changed to separate the flow path from which the dialysis fluid is supplied from the flow path discharged from the first filter 20. When blood or used dialysate flows to one side of the first filter separation membrane 22, clean dialysate flows to the other side of the first filter separation membrane. At this time, the dialysis efficiency may be further increased by separating the flow passage through which the clean dialysis liquid is supplied to the first filter and the flow passage discharged from the first filter. FIG. 10 shows a composite function filter 10 having a second flow path as well as a first flow path 71 to separate the supply and discharge of the dialysate through the first filter. In FIG. 10, the cut plane A-A shows a cut plane of the multi-function filter top view, as shown in FIG. 1.

To this end, as shown in FIG. 11A, the flow passage connector 60 accommodates not only the connecting

portions

61 and 62 but also the first filter 20 and partitions the dialysate flow path outside the first filter. It has a first filter receiving space 63, one end of the first filter receiving space is coupled to the first cap. In addition, as shown in FIG. 11 (b), the second filter hole 24 is further provided in the first filter container 21 so as to surround the circumferential direction of the container. The second flow hole is preferably provided on the side opposite to the first flow hole 23 around the longitudinal interruption of the container.

In addition, as can be seen in Figure 10 (b), the first cap 40, in addition to the first passage 43 for connecting the filter coupling portion 42 and the cap outer surface, and penetrates the cap to the adsorption section of the cap A second passageway 44 is further provided which connects the abutting surface with the cap outer surface.

The second flow passage 72 may be formed through the combination of the flow passage partition connector 60, the first filter 20, and the first cap 40. 12 (a) and 12 (b), the first filter 20 is located in the first filter receiving space 63 of the flow path connecting connector 60 and one end of the first filter is connected to the flow path connecting connector. When coupled to the connecting portion 61, the dialysate inside the first filter is partitioned to flow through the second flow hole 24 to the first filter receiving space (63). Subsequently, as shown in FIG. 12 (c), when the flow path connecting connector 60 and the first cap 40 are coupled, the second passage in which the dialysis fluid flowing in the first filter accommodation space 63 is provided in the first cap is provided. Partitioned to pass 44. In this way, a second flow path 72 connecting the first filter, the second flow hole, the first filter accommodation space, and the second passage is formed through the combination of the first filter, the flow passage partition connector, and the first cap. . When the dialysate is supplied through one of the first and

second flow paths

71 and 72, it is preferable that the dialysis fluid is discharged through the other flow path.

As such, the dialysis fluid is defined to flow through a predetermined space through the combination of the first cap 40, the first filter 20, and the flow path connecting connector 60, and various methods described above may be used.

Here, looking at the flow inside the composite function filter 10 shown in FIG. 7 or 9, the plasma or ultrafiltration dialysis fluid separated from the second filter 30 is moved to the adsorption section via the third flow hole 33. do. That is, the second filter and the suction section are connected to each other through the third flow hole. However, in the composite function filter 10 according to one embodiment of the present invention, as shown in FIG. 13, after the fluid of the second filter 30 is discharged to the outside of the composite function filter through the second cap, the adsorption section is provided. It can be changed to be supplied to. Likewise, in FIG. 13, the cut plane A-A means a cut plane of the multi-function filter top view.

To this end, the third flow hole 33 installed on the side wall of the second filter container 31 is changed to be installed on the side that is coupled to the second cap 50 of the container, as shown in FIG. The second cap 50 is provided with a third passage 53 penetrating the cap and having one end adjacent to the filter coupling portion 52 and the other end touching the second cap outer surface. 13 (b) shows a second cap provided with a third passage.

As described above, one end of the second filter container 31 is located in the second cap filter coupler 52 so that the second filter 30 and the second cap 50 are coupled to each other. When the second filter and the second cap are coupled, the fluid passing through the third flow hole 33 is partitioned to pass through the third passage 53 provided in the second cap. The formation of the third flow path 73 partitioned through the combination of the second filter and the second cap is the same as the formation principle of the first flow path shown in FIG. That is, a third flow path 73 connecting the second filter 30, the third flow hole 33, and the third passage 53 is formed through the combination of the second filter and the second cap. Through this, the fluid inside the second filter may be discharged to the outside and then supplied back to the adsorption section.

FIG. 15 shows an example flow inside the composite function filter 10 according to an embodiment of the present invention having the third flow path. Plasma or ultrafiltered dialysate separated from the second filter 30 is discharged through the third flow path 73, and then adsorbed through the flow pipe 81 connecting the third passage 53 and the housing port 13. It is supplied to the section. At this time, the pump 82 may be installed in the flow pipe connecting the third passage 43 and the housing port 13 to facilitate the flow through the adsorption section.

Here, similarly to the first and

second flow paths

71 and 72 provided to separate the supply and discharge of the dialysate through the first filter 20, the composite function filter 10 according to an embodiment of the present invention is first In order to separate the outflow and inflow of the fluid through the second filter 30, it may be changed to have not only the third flow path 73 but also the fourth flow path. FIG. 16 illustrates a multiple function filter having a fourth flow path outside the second filter 30. Similarly, cut planes A-A mean cut planes of the multifunction filter top view.

In order to form the fourth flow path, the flow passage partition connector 60 includes a second filter accommodating space 64 for accommodating the second filter and partitioning the flow path outside the second filter, as shown in FIG. 17A. It further has, one end of the second filter receiving space is coupled to the second cap.

In addition, as shown in FIG. 17 (b), the second filter container 31 surrounds the circumferential direction of the container, in addition to the third flow hole 33 provided on the side engaged with the second cap 50 of the container. The fourth flow hole 34 is further installed. The fourth flow hole is preferably installed on the side opposite to the third flow hole 33 centered on the longitudinal interruption of the container.

In addition, the second cap 50 is further provided with a fourth passage 54 penetrating the cap and connecting the cap outer surface and the cap outer surface. In FIG. 16B, the second cap in which the fourth passage 54 is installed is illustrated.

FIG. 18 illustrates a fourth flow path 74 formed through the combination of the flow path connector 60, the second filter 30, and the second cap 50. 18 (a) and 18 (b), the second filter 30 is located in the second filter receiving space 64 of the flow passage connector 60, and one end of the second filter is the connection portion of the flow passage connector. When coupled to 62, the fluid inside the second filter is partitioned to flow through the fourth flow hole 34 into the second filter receiving space 64. Subsequently, as shown in FIG. 18C, when the flow path connecting connector 60 and the second cap 50 are coupled to each other, a fluid that flows through the second filter accommodation space 64 is provided in the fourth passage ( 54). That is, a fourth flow path 74 connecting the second filter, the fourth flow hole, the second filter accommodation space, and the fourth passage is formed. When the fluid of the second filter flows through any one of the third flow path 73 and the fourth flow path 74, it is preferable to return to the second filter through the other flow path.

FIG. 19 illustrates an example flow inside a composite function filter 10 according to an embodiment of the present invention having a fourth flow path 74. The fluid separated across the second filter separation membrane is discharged through the third flow path 73, and is supplied to the adsorption section through the flow pipe 81 connecting the second cap 50 and the housing port 13. The fluid from which the toxins and the wastes are removed while passing through the adsorption section may be returned to the second filter through the fourth flow path 74. At this time, the pump 82 may be installed in the flow pipe connecting the second cap and the housing port in order to facilitate the flow through the adsorption section.

Referring to the flow of FIG. 19, a fluid such as plasma or dialysate is separated from the second filter separation membrane 32 close to the second cap, and the separated fluid passes through the adsorption section, and then the separation membrane opposite to the second cap. It can be seen that it is returned to (32). As such, when separation and return of the fluid occur in the second filter, the fluid returned through the fourth flow path 74 may be immediately discharged through the third flow path 73 without flowing into the separation membrane. In order to suppress the recirculation of the fluid as shown in Fig. 19 or 17 (b), the inner wall protrusion 35 may be provided on the inner wall of the second filter container. The inner wall protrusion reduces the inner diameter of the second filter container 31 and can distinguish between the discharged area and the returned area of the fluid separated in the second filter.

The inner wall protrusion may also be installed in the first filter container 21. When the dialysate passes through the first filter, the dialysate can make a larger pressure change by the inner wall protrusion installed inside the first filter, thereby further improving the dialysing efficiency by filtration.

Finally, the fourth flow path 74 is not limited to passing through the second cap. As shown in FIG. 20, the fluid passing through the adsorption section 12 through the flow passage connector flow hole 65 installed at the position biased toward the side where the second cap of the flow passage connector 60 is located is connected to the housing port 13. It may be returned to the second filter 30 directly without passing through. The housing port 13 and the flow passage connector flow hole 65 are connected to each other in the longitudinal direction of the multifunction filter so that the fluid introduced through the housing port 13 can be sufficiently contacted with the adsorbent in the adsorption section and then returned to the second filter. It is preferable to be installed on the opposite side. At this time, the fourth passage 54 installed in the second cap is unnecessary.

FIG. 21 illustrates an example flow inside a composite function filter including flow path segment flow holes 65. The fluid separated from the second filter 30 is discharged through the third flow path 73 and then supplied to the adsorption section through the flow pipe 81 connecting the third passage and the housing port. The fluid from which the toxins and the wastes are removed while passing through the adsorption section may be returned to the second filter through the flow passage connector flow hole 65, the second filter receiving space 64, and the fourth flow hole 34.

At this time, it is preferable that the movement of the adsorbent does not occur through the housing port 13 or the flow path connector flow hole 65, and the aforementioned various methods may be used.

As described above, the multi-function filter 10 according to an embodiment of the present invention integrates the functions of dialysis, adsorption, plasma separation or dialysis, adsorption, ultrafiltration, etc. in order to purify the blood or used dialysis solution, By smoothly configuring the flow inside the filter, it is possible to provide a blood purification device which can simplify the whole device, is easy to install and use, and reduce the treatment cost.

As described above, the embodiments of the present invention described and illustrated in the drawings should not be construed as limiting the technical idea of the present invention, and the protection scope of the present invention is limited by the matters described in the claims. Those of ordinary skill in the art of the present invention can improve or change the technical idea of the present invention in various forms, and such improvements and modifications will fall within the protection scope of the present invention.

Claims

A first filter comprising a container having an inner space and a separator accommodated in the inner space of the container;

A second filter including a container having an inner space and a separator accommodated in the inner space of the container;

A housing which provides an installation space between the first filter and the second filter, and partitions the suction section outside the first filter and the second filter; And

And a housing port installed in the housing to allow flow to occur through the adsorption section.
The method of claim 1

The first filter and the second filter container has a flow hole through which the fluid can pass through at least one of the two sides in the longitudinal direction of the longitudinal interruption of the container.
The method of claim 2,

The housing,

Wall;

A first cap coupled to the first filter on one side of the wall in the longitudinal direction;

And a second cap coupled to the second filter on the other side in the longitudinal direction of the wall.
The method of claim 3, wherein

And a flow path segment connector connecting the first filter and the second filter so that there is no fluid leakage between the first filter and the second filter.
The method of claim 4, wherein

At least one cap of the first and second caps, passage through the cap and one end adjacent to the filter coupling portion of the cap; multifunctional filter comprising a.
The method of claim 5,

The flow passage segment connector is coupled to at least one of the caps of the first cap and the second cap, the cap coupled to the flow passage segment, the passage penetrates through the cap and the end adjacent to the surface in contact with the suction section of the cap; Multiple function filter, characterized in that it further has.
The method of claim 5,

Both ends of the flow path connector are coupled to the first cap and the second cap,

The cap of any one of the first cap and the second cap, the passage penetrates adjacent to the surface of the cap is in contact with the suction section of the cap;

The flow path partition connector has a flow hole through which the fluid passes through the circumferential direction; multi-function filter characterized in that it has a.
The method according to any one of claims 2 to 7,

The adsorption section is a combined function filter is provided; to remove the waste.
The method of claim 8,

In order to prevent the movement of the adsorbent through the housing port or the flow hole,

Make the housing port or flow hole smaller than the adsorbent,

Wrap the housing port or flow hole with a mesh filter with pores smaller than the adsorbent,

Wrap the adsorbent with a mesh filter with pores of smaller size than the adsorbent,

Using adsorbent blocks in which powder or granule adsorbents are compressed, or

A composite function filter is installed; to prevent the passage of the adsorbent;
The method of claim 9,

The separation wall may include a mesh filter having pores of a smaller size than the adsorbent or a support wall through which fluid may pass; The composite function filter characterized by having.
The method of claim 8,

And an inner wall protrusion installed on an inner wall of the first filter container or the second filter container to reduce an inner diameter of the container.
The composite function filter of claim 9;

A flow tube connected to the multifunction filter and in which blood or plasma flows; And

And a pump installed in the flow tube and transferring blood or plasma.
The method of claim 12,

At least one of the first filter membrane and the second filter membrane is a dialysis membrane and the other blood purification device, characterized in that the plasma separation membrane.
A blood filter through which the blood and the dialysate pass and a mass transfer between the blood and the dialysate;

A flow pipe connected to the blood filter and in which blood or dialysis fluid flows;

A pump installed in the flow pipe to transfer blood or dialysate; And

Blood purification device comprising a; the multifunction filter of claim 9 to purify the dialysate.